﻿                        序列表

<110> 臻崴生物科技有限公司

<120> 单克隆抗体或其抗原結合片段及其用途

<130>

<150> US 62/560,202
<151> 2017-09-19

<160> 33


<210> 1
<211> 9
<212> PRT
<213> 人工序列

<220>
<223> Human sapiens PTX3  第200至208個氨基酸

<400> 1
Arg Pro Met Arg Leu Glu Ser Phe Ser
 1               5


<210> 2
<211> 9
<212> PRT
<213> 人工序列

<220>
<223> Human sapiens PTX3  第203至211個氨基酸

<400> 2
Arg Leu Glu Ser Phe Ser Ala Cys Ile
 1               5


<210> 3
<211> 9
<212> PRT
<213> 人工序列

<220>
<223> Human sapiens PTX3  第206至214個氨基酸

<400> 3
Ser Phe Ser Ala Cys Ile Trp Val Lys
 1               5


<210> 4
<211> 9
<212> PRT
<213> 人工序列

<220>
<223> Human sapiens PTX3  第209至217個氨基酸

<400> 4
Ala Cys Ile Trp Val Lys Ala Thr Asp
 1               5


<210> 5
<211> 9
<212> PRT
<213> 人工序列

<220>
<223> Human sapiens PTX3  第212至220個氨基酸

<400> 5
Trp Val Lys Ala Thr Asp Val Leu Asn
 1               5


<210> 6
<211> 9
<212> PRT
<213> 人工序列

<220>
<223> Human sapiens PTX3  第215至223個氨基酸

<400> 6
Ala Thr Asp Val Leu Asn Lys Thr Ile
 1               5


<210> 7
<211> 9
<212> PRT
<213> 人工序列

<220>
<223> Human sapiens PTX3  第218至226個氨基酸

<400> 7
Val Leu Asn Lys Thr Ile Leu Phe Ser
 1               5


<210> 8
<211> 9
<212> PRT
<213> 人工序列

<220>
<223> Human sapiens PTX3  第221至229個氨基酸

<400> 8
Lys Thr Ile Leu Phe Ser Tyr Gly Thr
 1               5


<210> 9
<211> 9
<212> PRT
<213> 人工序列

<220>
<223> Human sapiens PTX3  第224至232個氨基酸

<400> 9
Leu Phe Ser Tyr Gly Thr Lys Arg Asn
 1               5


<210> 10
<211> 10
<212> PRT
<213> 人工序列

<220>
<223> Human sapiens PTX3  第227至236個氨基酸

<400> 10
Tyr Gly Thr Lys Arg Asn Pro Tyr Glu Ile
 1               5                   10


<210> 11
<211> 15
<212> PRT
<213> 人工序列

<220>
<223> Human sapiens PTX3  第203至217個氨基酸

<400> 11
Arg Leu Glu Ser Phe Ser Ala Cys Ile Trp Val Lys Ala Thr Asp
 1               5                   10                  15


<210> 12
<211> 37
<212> PRT
<213> 人工序列

<220>
<222> (200)...(236)
<223> Human sapiens PTX3 第200至236個氨基酸 (RI37)

<400> 12
Arg Pro Met Arg Leu Glu Ser Phe Ser Ala Cys Ile Trp Val Lys Ala 
 1               5                   10                  15
Thr Asp Val Leu Asn Lys Thr Ile Leu Phe Ser Tyr Gly Thr Lys Arg 
             20                  25                  30
Asn Pro Tyr Glu Ile
         35

<210> 13
<211> 160
<212> PRT
<213> 人工序列

<220>
<222> (200)...(359)
<223> 人类PTX3重组蛋白

<400> 13
Arg Pro Met Arg Leu Glu Ser Phe Ser Ala Cys Ile Trp Val Lys Ala
 1               5                   10                  15
Thr Asp Val Leu Asn Lys Thr Ile Leu Phe Ser Tyr Gly Thr Lys Arg
             20                  25                  30
Asn Pro Tyr Glu Ile Gln Leu Tyr Leu Ser Tyr Gln Ser Ile Val Phe
         35                  40                  45
Val Val Gly Gly Glu Glu Asn Lys Leu Val Ala Glu Ala Met Val Ser
     50                  55                  60
Leu Gly Arg Trp Thr His Leu Cys Gly Thr Trp Asn Ser Glu Glu Gly
 65                  70                  75                  80
Leu Thr Ser Leu Trp Val Asn Gly Glu Leu Ala Ala Thr Thr Val Glu
                 85                  90                  95
Met Ala Thr Gly His Ile Val Pro Glu Gly Gly Ile Leu Gln Ile Gly
            100                 105                 110
Gln Glu Lys Asn Gly Cys Cys Val Gly Gly Gly Phe Asp Glu Thr Leu
        115                 120                 125
Ala Phe Ser Gly Arg Leu Thr Gly Phe Asn Ile Trp Asp Ser Val Leu
    130                 135                 140
Ser Asn Glu Glu Ile Arg Glu Thr Gly Gly Ala Glu Ser Cys His Ile
145                 150                 155                 160


<210> 14
<211> 363
<212> PRT
<213> 人工序列

<220>
<222> (19)...(381)
<223> 人类PTX3重组蛋白

<400> 14
Asn Ser Asp Asp Tyr Asp Leu Met Tyr Val Asn Leu Asp Asn Glu Ile
 1               5                   10                  15
Asp Asn Gly Leu His Pro Thr Glu Asp Pro Thr Pro Cys Ala Cys Gly
             20                  25                  30
Gln Glu His Ser Glu Trp Asp Lys Leu Phe Ile Met Leu Glu Asn Ser
         35                  40                  45
Gln Met Arg Glu Arg Met Leu Leu Gln Ala Thr Asp Asp Val Leu Arg
     50                  55                  60
Gly Glu Leu Gln Arg Leu Arg Glu Glu Leu Gly Arg Leu Ala Glu Ser
 65                  70                  75                  80
Leu Ala Arg Pro Cys Ala Pro Gly Ala Pro Ala Glu Ala Arg Leu Thr
                 85                  90                  95
Ser Ala Leu Asp Glu Leu Leu Gln Ala Thr Arg Asp Ala Gly Arg Arg
            100                 105                 110
Leu Ala Arg Met Glu Gly Ala Glu Ala Gln Arg Pro Glu Glu Ala Gly
        115                 120                 125
Arg Ala Leu Ala Ala Val Leu Glu Glu Leu Arg Gln Thr Arg Ala Asp
    130                 135                 140
Leu His Ala Val Gln Gly Trp Ala Ala Arg Ser Trp Leu Pro Ala Gly
145                 150                 155                 160
Cys Glu Thr Ala Ile Leu Phe Pro Met Arg Ser Lys Lys Ile Phe Gly
                165                 170                 175
Ser Val His Pro Val Arg Pro Met Arg Leu Glu Ser Phe Ser Ala Cys
            180                 185                 190
Ile Trp Val Lys Ala Thr Asp Val Leu Asn Lys Thr Ile Leu Phe Ser
        195                 200                 205
Tyr Gly Thr Lys Arg Asn Pro Tyr Glu Ile Gln Leu Tyr Leu Ser Tyr
    210                 215                 220
Gln Ser Ile Val Phe Val Val Gly Gly Glu Glu Asn Lys Leu Val Ala
225                 230                 235                 240
Glu Ala Met Val Ser Leu Gly Arg Trp Thr His Leu Cys Gly Thr Trp
                245                 250                 255
Asn Ser Glu Glu Gly Leu Thr Ser Leu Trp Val Asn Gly Glu Leu Ala
            260                 265                 270
Ala Thr Thr Val Glu Met Ala Thr Gly His Ile Val Pro Glu Gly Gly
        275                 280                 285
Ile Leu Gln Ile Gly Gln Glu Lys Asn Gly Cys Cys Val Gly Gly Gly
    290                 295                 300
Phe Asp Glu Thr Leu Ala Phe Ser Gly Arg Leu Thr Gly Phe Asn Ile
305                 310                 315                 320
Trp Asp Ser Val Leu Ser Asn Glu Glu Ile Arg Glu Thr Gly Gly Ala
                325                 330                 335
Glu Ser Cys His Ile Arg Gly Asn Ile Val Gly Trp Gly Val Thr Glu
            340                 345                 350
Ile Gln Pro His Gly Gly Ala Gln Tyr Val Ser
        355                 360


<210> 15
<211> 381
<212> PRT
<213> 人工序列

<220>
<222> (1)...(381)
<223> 人类PTX3重组蛋白

<400> 15
Met His Leu Leu Ala Ile Leu Phe Cys Ala Leu Trp Ser Ala Val Leu
 1               5                   10                  15
Ala Glu Asn Ser Asp Asp Tyr Asp Leu Met Tyr Val Asn Leu Asp Asn
             20                  25                  30
Glu Ile Asp Asn Gly Leu His Pro Thr Glu Asp Pro Thr Pro Cys Ala
         35                  40                  45
Cys Gly Gln Glu His Ser Glu Trp Asp Lys Leu Phe Ile Met Leu Glu
     50                  55                  60
Asn Ser Gln Met Arg Glu Arg Met Leu Leu Gln Ala Thr Asp Asp Val
 65                  70                  75                  80
Leu Arg Gly Glu Leu Gln Arg Leu Arg Glu Glu Leu Gly Arg Leu Ala
                 85                  90                  95

Glu Ser Leu Ala Arg Pro Cys Ala Pro Gly Ala Pro Ala Glu Ala Arg
            100                 105                 110
Leu Thr Ser Ala Leu Asp Glu Leu Leu Gln Ala Thr Arg Asp Ala Gly
        115                 120                 125
Arg Arg Leu Ala Arg Met Glu Gly Ala Glu Ala Gln Arg Pro Glu Glu
    130                 135                 140
Ala Gly Arg Ala Leu Ala Ala Val Leu Glu Glu Leu Arg Gln Thr Arg
145                 150                 155                 160
Ala Asp Leu His Ala Val Gln Gly Trp Ala Ala Arg Ser Trp Leu Pro
                165                 170                 175
Ala Gly Cys Glu Thr Ala Ile Leu Phe Pro Met Arg Ser Lys Lys Ile
            180                 185                 190
Phe Gly Ser Val His Pro Val Arg Pro Met Arg Leu Glu Ser Phe Ser
        195                 200                 205
Ala Cys Ile Trp Val Lys Ala Thr Asp Val Leu Asn Lys Thr Ile Leu
    210                 215                 220
Phe Ser Tyr Gly Thr Lys Arg Asn Pro Tyr Glu Ile Gln Leu Tyr Leu
225                 230                 235                 240
Ser Tyr Gln Ser Ile Val Phe Val Val Gly Gly Glu Glu Asn Lys Leu
                245                 250                 255
Val Ala Glu Ala Met Val Ser Leu Gly Arg Trp Thr His Leu Cys Gly
            260                 265                 270
Thr Trp Asn Ser Glu Glu Gly Leu Thr Ser Leu Trp Val Asn Gly Glu
        275                 280                 285
Leu Ala Ala Thr Thr Val Glu Met Ala Thr Gly His Ile Val Pro Glu
    290                 295                 300
Gly Gly Ile Leu Gln Ile Gly Gln Glu Lys Asn Gly Cys Cys Val Gly
305                 310                 315                 320
Gly Gly Phe Asp Glu Thr Leu Ala Phe Ser Gly Arg Leu Thr Gly Phe
                325                 330                 335
Asn Ile Trp Asp Ser Val Leu Ser Asn Glu Glu Ile Arg Glu Thr Gly
            340                 345                 350
Gly Ala Glu Ser Cys His Ile Arg Gly Asn Ile Val Gly Trp Gly Val
        355                 360                 365
Thr Glu Ile Gln Pro His Gly Gly Ala Gln Tyr Val Ser
    370                 375                 380


<210>	16
<211>	44
<212>	PRT
<213>	人工序列

<220>	
<223>	Human sapiens PTX3 第255至298個氨基酸 (KT44)

<400>	16
Lys Leu Val Ala Glu Ala Met Val Ser Leu Gly Arg Trp Thr His Leu
 1               5                   10                  15
Cys Gly Thr Trp Asn Ser Glu Glu Gly Leu Thr Ser Leu Trp Val Asn 
             20                  25                  30
Gly Glu Leu Ala Ala Thr Thr Val Glu Met Ala Thr
         35                  40


<210>	17
<211>	40
<212>	PRT
<213>	人工序列

<220>	
<223>	Human sapiens PTX3 第320至359個氨基酸 (GI40)

<400>	17
Gly Gly Gly Phe Asp Glu Thr Leu Ala Phe Ser Gly Arg Leu Thr Gly 
 1               5                   10                  15
Phe Asn Ile Trp Asp Ser Val Leu Ser Asn Glu Glu Ile Arg Glu Thr 
             20                  25                  30
Gly Gly Ala Glu Ser Cys His Ile
         35                  40


<210> 18
<211> 10
<212> PRT
<213> 人工序列

<220>
<221> V_segment
<223> PTX3单克隆抗体重链可变区的CDR1

<400> 18
Asp Phe Asn Ile Lys His Thr Tyr Leu His
 1               5                   10


<210> 19
<211> 17
<212> PRT
<213> 人工序列

<220>
<221> V_segment
<223> PTX3单克隆抗体重链可变区的CDR2

<400> 19
Arg Ile Asp Pro Ala Asn Asp Asn Thr Lys Tyr Asp Pro Met Phe Gln
 1               5                   10                  15
Gly
 17


<210> 20
<211> 11
<212> PRT
<213> 人工序列

<220>
<221> V_segment
<223> PTX3单克隆抗体重链可变区的CDR3

<400> 20
Ala Arg Val Thr Thr Val Val Gly Phe Asp Tyr
 1               5                   10 


<210> 21
<211> 12
<212> PRT
<213> 人工序列

<220>
<221> V_segment
<223> PTX3单克隆抗体轻链可变区的CDR1

<400> 21
Thr Ala Ser Ser Ser Val Ile Ser Thr Tyr Leu Asn
 1               5                   10 


<210> 22
<211> 7
<212> PRT
<213> 人工序列

<220>
<221> V_segment
<223> PTX3单克隆抗体轻链可变区的CDR2

<400> 22
Ser Thr Ser Asn Leu Ala Ser
 1               5 


<210> 23
<211> 9
<212> PRT
<213> 人工序列

<220>
<221> V_segment
<223> PTX3单克隆抗体轻链可变区的CDR3

<400> 23
His Gln Phe Gln Arg Ser Pro Leu Thr
 1               5


<210> 24
<211> 30
<212> DNA
<213> 人工序列

<220>
<221> V_segment基因
<223> PTX3单克隆抗体重链可变区的CDR1的核酸序列

<400> 24
gacttcaaca ttaaacatac ctatctgcac                                  30


<210> 25
<211> 51
<212> DNA
<213> 人工序列

<220>
<221> V_segment基因
<223> PTX3单克隆抗体重链可变区的CDR2基因


<400> 25
aggattgatc ctgcgaatga taatactaaa tatgacccga tgttccaggg c         51


<210> 26
<211> 33
<212> DNA
<213> 人工序列

<220>
<221> V_segment基因
<223> PTX3单克隆抗体重链可变区的CDR3基因

<400> 26
gctagagtta ctacggttgt aggctttgac tac                              33


<210> 27
<211> 27
<212> DNA
<213> 人工序列

<220>
<221> V_segment基因
<223> PTX3单克隆抗体轻链可变区的CDR1基因

<400> 27
actgccagct caagtgtaat ttccact                                    27


<210> 28
<211> 21
<212> DNA
<213> 人工序列

<220>
<221> V_segment基因
<223> PTX3单克隆抗体轻链可变区的CDR2基因

<400> 28
agcacatcca acctggcttc t                                           21


<210> 29
<211> 27
<212> DNA
<213> 人工序列

<220>
<221> V_segment基因
<223> PTX3单克隆抗体轻链可变区的CDR3基因

<400> 29
caccagtttc agcgttcccc gctcacg


<210> 30
<211> 118
<212> PRT
<213> 人工序列

<220>
<221> V_region
<223> PTX3单克隆抗体重链可变区

<400> 30
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                   10                  15
Ser Val Lys Leu Ser Cys Thr Ala Ser Asp Phe Asn Ile Lys His Thr
             20                  25                  30
Tyr Leu His Trp Val Leu Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
         35                  40                  45
Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Lys Tyr Asp Pro Met Phe
     50                  55                  60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
 65                  70                  75                  80
Leu His Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95
Ala Arg Val Thr Thr Val Val Gly Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Thr Leu Thr Val Ser Ser
        115


<210> 31
<211> 109
<212> PRT
<213> 人工序列

<220>
<221> V_region
<223> PTX3单克隆抗体轻链可变区

<400> 31
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Thr Ser Leu Gly
 1               5                   10                  15
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ile Ser Thr
             20                  25                  30
Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
         35                  40                  45
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
     50                  55                  60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
 65                  70                  75                  80
Ala Glu Asp Ala Ala Thr Tyr Phe Cys His Gln Phe Gln Arg Ser Pro
                 85                  90                  95
Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg
            100                 105


<210> 32
<211> 354
<212> DNA
<213> 人工序列

<220>
<221> CDS
<223> PTX3单克隆抗体重链可变区的基因序列

<400> 32
gaggttcagc tgcagcagtc tggggcagag cttgtgaagc caggggcctc agtcaagttg  60
tcctgcacag cttctgactt caacattaaa catacctatc tgcactgggt gctccagagg 120
cctgaacagg gcctggagtg gattggaagg attgatcctg cgaatgataa tactaaatat 180
gacccgatgt tccagggcaa ggccactata acagcagaca catcctccaa cacagcctac 240
ctgcacctca gcagcctgac atctgaggac actgccgtct attactgtgc tagagttact 300
acggttgtag gctttgacta ctggggccaa ggcaccactc tcacagtctc ctca       354


<210> 33
<211> 327
<212> DNA
<213> 人工序列

<220>
<221> CDS
<223> PTX3单克隆抗体轻链可变区的基因序列

<400> 33
caaattgttc tcacccagtc tccagcaatc atgtctacat ctctagggga acgggtcacc  60
atgacctgca ctgccagctc aagtgtaatt tccacttact tgaactggta ccagcagaag 120
ccaggatcct cccccaaact ctggatttat agcacatcca acctggcttc tggagtccca 180
gctcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaatcag tagcatggag 240
gctgaagatg ctgccactta tttctgccac cagtttcagc gttccccgct cacgttcggt 300
gctgggacca agctggagct gaaacgg                                     327

 
