               SEQUENCE LISTING

<110> THE UNIVERSITY OF BRITISH COLUMBIA
      TXCELL

<120> NOVEL ANTI-HLA-A2 ANTIBODIES AND USES THEREOF

<130> P1526PC00

<140> NOT YET ASSIGNED
<141> 2018-09-20

<150> US 62/560,841
<151> 2017-09-20

<150> US 62/691,027
<151> 2018-06-28

<160> 89

<170> BiSSAP 1.3.6

<210> 1
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR1

<400> 1
Ser Tyr His Ile Gln 
1               5   

<210> 2
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR2

<400> 2
Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 3
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR3

<400> 3
Glu Gly Thr Tyr Tyr Ala Met Asp Tyr 
1               5                   

<210> 4
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR1

<400> 4
Gly Tyr Thr Phe Thr Ser Tyr 
1               5           

<210> 5
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-CDR2

<400> 5
Tyr Pro Gly Asp Gly Ser 
1               5       

<210> 6
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR1

<400> 6
Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      

<210> 7
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR2

<400> 7
Lys Val Ser Asn Arg Phe Ser 
1               5           

<210> 8
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-CDR3

<400> 8
Phe Gln Gly Ser His Val Pro Arg Thr 
1               5                   

<210> 9
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 9
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
His Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Val Thr Val Ser Ser 
        115             

<210> 10
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<220> 
<221> SITE
<222> 2
<223> X is V or I

<220> 
<221> SITE
<222> 7
<223> X is T or S

<220> 
<221> SITE
<222> 9
<223> X is L or S or A

<220> 
<221> SITE
<222> 10
<223> X is S or T

<220> 
<221> SITE
<222> 12
<223> X is P or S

<220> 
<221> SITE
<222> 14
<223> X is T or S

<220> 
<221> SITE
<222> 15
<223> X is L or P

<220> 
<221> SITE
<222> 17
<223> X is E or D

<220> 
<221> SITE
<222> 18
<223> X is P or R

<220> 
<221> SITE
<222> 19
<223> X is A or V

<220> 
<221> SITE
<222> 20
<223> X is S or T

<220> 
<221> SITE
<222> 42
<223> X is L or Q

<220> 
<221> SITE
<222> 48
<223> X is S or A

<220> 
<221> SITE
<222> 63
<223> X is V or I

<220> 
<221> SITE
<222> 79
<223> X is K or T


<220> 
<221> SITE
<222> 83
<223> X is V or L

<220> 
<221> SITE
<222> 85
<223> X is A or P

<220> 
<221> SITE
<222> 88
<223> X is L or F

<220> 
<221> SITE
<222> 89
<223> X is G or A

<400> 10
Asp Xaa Val Met Thr Gln Xaa Pro Xaa Xaa Leu Xaa Val Xaa Xaa Gly 
1               5                   10                  15      
Xaa Xaa Xaa Xaa Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Xaa Gln Lys Pro Gly Gln Xaa 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Xaa Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Xaa Ile 
65                  70                  75                  80  
Ser Arg Xaa Glu Xaa Glu Asp Xaa Xaa Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
Arg 
    

<210> 11
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 11
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
Arg 
    

<210> 12
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 12
Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Thr Leu Gly 
1               5                   10                  15      
Asp Arg Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  
Ser Arg Val Glu Pro Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
Arg 
    

<210> 13
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 13
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Ile Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  
Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
Arg 
    

<210> 14
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> G3S linker

<400> 14
Gly Gly Gly Ser 
1               

<210> 15
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> G3S linker

<400> 15
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      

<210> 16
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> G4S linker

<400> 16
Gly Gly Gly Gly Gly Ser 
1               5       

<210> 17
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> G4S linker

<400> 17
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  

<210> 18
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> G4S linker

<400> 18
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

<210> 19
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> G4S linker

<400> 19
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser 
            20  

<210> 20
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hinge domain

<400> 20
Ala Gly Ser Ser Ser Ser Gly Gly Ser Thr Thr Gly Gly Ser Thr Thr 
1               5                   10                  15      

<210> 21
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hinge domain

<400> 21
Gly Thr Thr Ala Ala Ser Gly Ser Ser Gly Gly Ser Ser Ser Gly Ala 
1               5                   10                  15      

<210> 22
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hinge domain

<400> 22
Ser Ser Ala Thr Ala Thr Ala Gly Thr Gly Ser Ser Thr Gly Ser Thr 
1               5                   10                  15      

<210> 23
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hinge domain

<400> 23
Thr Ser Gly Ser Thr Gly Thr Ala Ala Ser Ser Thr Ser Thr Ser Thr 
1               5                   10                  15      

<210> 24
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Hinge domain

<400> 24
ggtggcggag gttctggagg tggaggttcc                                     30

<210> 25
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hinge domain

<400> 25
Lys Ile Arg Arg Asp Ser Ser 
1               5           

<210> 26
<211> 45
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD8 Hinge domain

<400> 26
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  

<210> 27
<211> 135
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD8 Hinge domain

<400> 27
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg     60
tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg    120
gacttcgcct gtgat                                                     135

<210> 28
<211> 230
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG4 Hinge domain

<400> 28
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              
Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         
Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             
Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 
Leu Ser Leu Gly Lys Met 
225                 230 

<210> 29
<211> 690
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG4 Hinge domain

<400> 29
gagagcaagt acggccctcc ctgcccccct tgccctgccc ccgagttcct gggcggaccc      60
agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagccg gacccccgag     120
gtgacctgtg tggtggtgga cgtgtcccag gaggaccccg aggtccagtt caactggtac     180
gtggacggcg tggaggtgca caacgccaag accaagcccc gggaggagca gttcaatagc     240
acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggaa     300
tacaagtgta aggtgtccaa caagggcctg cccagcagca tcgagaaaac catcagcaag     360
gccaagggcc agcctcggga gccccaggtg tacaccctgc cccctagcca agaggagatg     420
accaagaacc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgcc     480
gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg     540
gacagcgacg gcagcttctt cctgtacagc cggctgaccg tggacaagag ccggtggcag     600
gagggcaacg tctttagctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag     660
aagagcctga gcctgtccct gggcaagatg                                      690

<210> 30
<211> 282
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgD Hinge domain

<400> 30
Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala 
1               5                   10                  15      
Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala 
            20                  25                  30          
Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys 
        35                  40                  45              
Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro 
    50                  55                  60                  
Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln 
65                  70                  75                  80  
Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly 
                85                  90                  95      
Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val 
            100                 105                 110         
Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly 
        115                 120                 125             
Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn 
    130                 135                 140                 
Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro 
145                 150                 155                 160 
Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys 
                165                 170                 175     
Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser 
            180                 185                 190         
Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu 
        195                 200                 205             
Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala Pro 
    210                 215                 220                 
Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser 
225                 230                 235                 240 
Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr Thr 
                245                 250                 255     
Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser Arg 
            260                 265                 270         
Ser Leu Glu Val Ser Tyr Val Thr Asp His 
        275                 280         

<210> 31
<211> 847
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgD Hinge domain

<400> 31
aggtggcccg aaagtcccaa ggcccaggca tctagtgttc ctactgcaca gccccaggca      60
gaaggcagcc tagccaaagc tactactgca cctgccacta cgcgcaatac tggccgtggc     120
ggggaggaga agaaaaagga gaaagagaaa gaagaacagg aagagaggga gaccaagacc     180
cctgaatgtc catcccatac ccagccgctg ggcgtctatc tcttgactcc cgcagtacag     240
gacttgtggc ttagagataa ggccaccttt acatgtttcg tcgtgggctc tgacctgaag     300
gatgcccatt tgacttggga ggttgccgga aaggtaccca cagggggggt tgaggaaggg     360
ttgctggagc gccattccaa tggctctcag agccagcact caagactcac ccttccgaga     420
tccctgtgga acgccgggac ctctgtcaca tgtactctaa atcatcctag cctgccccca     480
cagcgtctga tggcccttag agagccagcc gcccaggcac cagttaagct tagcctgaat     540
ctgctcgcca gtagtgatcc cccagaggcc gccagctggc tcttatgcga agtgtccggc     600
tttagcccgc ccaacatctt gctcatgtgg ctggaggacc agcgagaagt gaacaccagc     660
ggcttcgctc cagcccggcc cccaccccag ccgggttcta ccacattctg ggcctggagt     720
gtcttaaggg tcccagcacc acctagcccc cagccagcca catacacctg tgttgtgtcc     780
catgaagata gcaggaccct gctaaatgct tctaggagtc tggaggtttc ctacgtgact     840
gaccatt                                                               847

<210> 32
<211> 39
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD28 Hinge domain

<400> 32
Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      
Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          
Phe Pro Gly Pro Ser Lys Pro 
        35                  

<210> 33
<211> 117
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD28 Hinge domain

<400> 33
attgaagtta tgtatcctcc tccttaccta gacaatgaga agagcaatgg aaccattatc     60
catgtgaaag ggaaacacct ttgtccaagt cccctatttc ccggaccttc taagccc       117

<210> 34
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD8 transmembrane domain

<400> 34
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      
Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  

<210> 35
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD8 transmembrane domain

<400> 35
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc     60
accctttact gc                                                         72

<210> 36
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD28 transmembrane domain

<400> 36
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      
Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          

<210> 37
<211> 81
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD28 transmembrane domain

<400> 37
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg     60
gcctttatta ttttctgggt g                                               81

<210> 38
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3zeta

<400> 38
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         

<210> 39
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3zeta

<400> 39
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         

<210> 40
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3zeta

<400> 40
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              
Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         
Arg 
    

<210> 41
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3zeta

<400> 41
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              
Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         
Arg 
    

<210> 42
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD3zeta

<400> 42
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc      60
tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     120
cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat     180
gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     240
cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     300
tacgacgccc ttcacatgca ggccctgccc cctcgc                               336

<210> 43
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD3zeta

<400> 43
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc      60
tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     120
cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat     180
gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     240
cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     300
tacgacgccc ttcacatgca ggccctgccc cctcgc                               336

<210> 44
<211> 42
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4-1BB intracellular domain

<400> 44
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          

<210> 45
<211> 48
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD27 intracellular domain

<400> 45
Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      
Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          
Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              

<210> 46
<211> 41
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD28 intracellular domain

<400> 46
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      
Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          
Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      

<210> 47
<211> 126
<212> DNA
<213> Artificial Sequence

<220> 
<223> 4-1BB intracellular domain

<400> 47
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa     60
actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt    120
gaactg                                                               126

<210> 48
<211> 144
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD27 intracellular domain

<400> 48
caacgaagga aatatagatc aaacaaagga gaaagtcctg tggagcctgc agagccttgt     60
cgttacagct gccccaggga ggaggagggc agcaccatcc ccatccagga ggattaccga    120
aaaccggagc ctgcctgctc cccc                                           144

<210> 49
<211> 123
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD28 intracellular domain

<400> 49
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc     60
gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc    120
tcc                                                                  123

<210> 50
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD8 leader sequence

<400> 50
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      
His Ala Ala Arg Pro 
            20      

<210> 51
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tag

<400> 51
Asn Trp Ser His Pro Gln Phe Glu Lys 
1               5                   

<210> 52
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tag

<400> 52
Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
1               5                   10  

<210> 53
<211> 222
<212> PRT
<213> Artificial Sequence

<220> 
<223> CAR

<400> 53
Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu 
1               5                   10                  15      
Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro 
            20                  25                  30          
Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
        35                  40                  45              
Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
    50                  55                  60                  
Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
65                  70                  75                  80  
Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                85                  90                  95      
Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
            100                 105                 110         
Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        115                 120                 125             
Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    130                 135                 140                 
Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
145                 150                 155                 160 
Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                165                 170                 175     
Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            180                 185                 190         
Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        195                 200                 205             
Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    210                 215                 220         

<210> 54
<211> 223
<212> PRT
<213> Artificial Sequence

<220> 
<223> CAR

<400> 54
Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu 
1               5                   10                  15      
Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro 
            20                  25                  30          
Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
        35                  40                  45              
Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
    50                  55                  60                  
Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
65                  70                  75                  80  
Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                85                  90                  95      
Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
            100                 105                 110         
Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        115                 120                 125             
Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    130                 135                 140                 
Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln 
145                 150                 155                 160 
Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                165                 170                 175     
Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            180                 185                 190         
Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        195                 200                 205             
Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    210                 215                 220             

<210> 55
<211> 223
<212> PRT
<213> Artificial Sequence

<220> 
<223> CAR

<400> 55
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              
Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  
Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
65                  70                  75                  80  
Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                85                  90                  95      
Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
            100                 105                 110         
Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
        115                 120                 125             
Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    130                 135                 140                 
Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
145                 150                 155                 160 
Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                165                 170                 175     
Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            180                 185                 190         
Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        195                 200                 205             
Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    210                 215                 220             

<210> 56
<211> 236
<212> PRT
<213> Artificial Sequence

<220> 
<223> CAR

<400> 56
Asn Trp Ser His Pro Gln Phe Glu Lys Met His Thr Thr Thr Pro Ala 
1               5                   10                  15      
Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
            20                  25                  30          
Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
        35                  40                  45              
Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
    50                  55                  60                  
Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
65                  70                  75                  80  
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
                85                  90                  95      
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            100                 105                 110         
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Thr Arg Arg Val Lys Phe 
        115                 120                 125             
Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
    130                 135                 140                 
Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
145                 150                 155                 160 
Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
                165                 170                 175     
Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
            180                 185                 190         
Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
        195                 200                 205             
Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
    210                 215                 220                 
Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
225                 230                 235     

<210> 57
<211> 224
<212> PRT
<213> Artificial Sequence

<220> 
<223> CAR

<400> 57
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              
Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  
Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
65                  70                  75                  80  
Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                85                  90                  95      
Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
            100                 105                 110         
Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
        115                 120                 125             
Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    130                 135                 140                 
Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
145                 150                 155                 160 
Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
                165                 170                 175     
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
            180                 185                 190         
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
        195                 200                 205             
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    210                 215                 220                 

<210> 58
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> CAR

<400> 58
Asn Trp Ser His Pro Gln Phe Glu Lys Met His Thr Thr Thr Pro Ala 
1               5                   10                  15      
Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
            20                  25                  30          
Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
        35                  40                  45              
Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
    50                  55                  60                  
Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
65                  70                  75                  80  
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
                85                  90                  95      
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            100                 105                 110         
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Thr Arg Arg Val Lys Phe 
        115                 120                 125             
Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
    130                 135                 140                 
Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
145                 150                 155                 160 
Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
                165                 170                 175     
Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            180                 185                 190         
Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        195                 200                 205             
Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    210                 215                 220                 
Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
225                 230                 235         

<210> 59
<211> 226
<212> PRT
<213> Artificial Sequence

<220> 
<223> CAR

<400> 59
Met His Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      
Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            20                  25                  30          
Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45              
Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    50                  55                  60                  
Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His 
65                  70                  75                  80  
Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                85                  90                  95      
His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            100                 105                 110         
Thr Arg Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
        115                 120                 125             
Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    130                 135                 140                 
Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
145                 150                 155                 160 
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
                165                 170                 175     
Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
            180                 185                 190         
Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        195                 200                 205             
Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
    210                 215                 220                 
Pro Arg 
225     

<210> 60
<211> 227
<212> PRT
<213> Artificial Sequence

<220> 
<223> CAR

<400> 60
Met His Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      
Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            20                  25                  30          
Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45              
Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    50                  55                  60                  
Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His 
65                  70                  75                  80  
Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                85                  90                  95      
His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            100                 105                 110         
Thr Arg Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
        115                 120                 125             
Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    130                 135                 140                 
Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
145                 150                 155                 160 
Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                165                 170                 175     
Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            180                 185                 190         
Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        195                 200                 205             
Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    210                 215                 220                 
Pro Pro Arg 
225         

<210> 61
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> P2A ribosomal cleavage site

<400> 61
Ala Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
1               5                   10                  15      
Asp Val Glu Glu Asn Pro Gly Pro 
            20                  

<210> 62
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain CDR1 of BB7.2

<400> 62
Ser Tyr His Ile Gln 
1               5   

<210> 63
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain CDR2 of BB7.2

<400> 63
Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 64
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain CDR3 of BB7.2

<400> 64
Glu Gly Thr Tyr Tyr Ala Met Asp Tyr 
1               5                   

<210> 65
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain CDR1 of BB7.2

<400> 65
Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      

<210> 66
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain CDR2 of BB7.2

<400> 66
Lys Val Ser Asn Arg Phe Ser 
1               5           

<210> 67
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain CDR3 of BB7.2

<400> 67
Phe Gln Gly Ser His Val Pro Arg Thr 
1               5                   

<210> 68
<211> 239
<212> PRT
<213> Artificial Sequence

<220> 
<223> eGFP

<400> 68
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      
Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          
Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              
Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  
Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  
Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      
Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         
Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             
Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 
Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 
Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     
Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         
Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             
Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 
Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 

<210> 69
<211> 246
<212> PRT
<213> Artificial Sequence

<220> 
<223> scFv

<220> 
<221> SITE
<222> 135
<223> X is for V or I

<220> 
<221> SITE
<222> 140
<223> X is for T or S

<220> 
<221> SITE
<222> 142
<223> X is for L or S or A

<220> 
<221> SITE
<222> 143
<223> X is for S or T

<220> 
<221> SITE
<222> 145
<223> X is for P or S

<220> 
<221> SITE
<222> 147
<223> X is for T or S

<220> 
<221> SITE
<222> 148
<223> X is for L or P

<220> 
<221> SITE
<222> 150
<223> X is for E or D

<220> 
<221> SITE
<222> 151
<223> X is for P or R

<220> 
<221> SITE
<222> 152
<223> X is for A or V

<220> 
<221> SITE
<222> 153
<223> X is for S or T

<220> 
<221> SITE
<222> 175
<223> X is for L or Q

<220> 
<221> SITE
<222> 181
<223> X is for S or A

<220> 
<221> SITE
<222> 196
<223> X is for V or I

<220> 
<221> SITE
<222> 212
<223> X is for K or T

<220> 
<221> SITE
<222> 216
<223> X is for V or L

<220> 
<221> SITE
<222> 218
<223> X is for A or P

<220> 
<221> SITE
<222> 221
<223> X is for L or F

<220> 
<221> SITE
<222> 222
<223> X is for G or A

<400> 69
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
His Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Asp Xaa Val Met Thr Gln Xaa Pro Xaa Xaa Leu 
    130                 135                 140                 
Xaa Val Xaa Xaa Gly Xaa Xaa Xaa Xaa Ile Ser Cys Arg Ser Ser Gln 
145                 150                 155                 160 
Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Xaa Gln 
                165                 170                 175     
Lys Pro Gly Gln Xaa Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg 
            180                 185                 190         
Phe Ser Gly Xaa Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             
Phe Thr Leu Xaa Ile Ser Arg Xaa Glu Xaa Glu Asp Xaa Xaa Val Tyr 
    210                 215                 220                 
Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 
Lys Leu Glu Ile Lys Arg 
                245     

<210> 70
<211> 246
<212> PRT
<213> Artificial Sequence

<220> 
<223> scFv

<400> 70
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
His Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu 
    130                 135                 140                 
Pro Val Thr Leu Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln 
145                 150                 155                 160 
Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln 
                165                 170                 175     
Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg 
            180                 185                 190         
Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             
Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
    210                 215                 220                 
Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 
Lys Leu Glu Ile Lys Arg 
                245     

<210> 71
<211> 246
<212> PRT
<213> Artificial Sequence

<220> 
<223> scFv

<400> 71
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
His Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 
Ser Val Thr Leu Gly Asp Arg Val Ser Ile Ser Cys Arg Ser Ser Gln 
145                 150                 155                 160 
Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln 
                165                 170                 175     
Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg 
            180                 185                 190         
Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             
Phe Thr Leu Thr Ile Ser Arg Val Glu Pro Glu Asp Leu Gly Val Tyr 
    210                 215                 220                 
Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 
Lys Leu Glu Ile Lys Arg 
                245     

<210> 72
<211> 246
<212> PRT
<213> Artificial Sequence

<220> 
<223> scFv

<400> 72
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
His Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 
Ser Val Ser Pro Gly Glu Arg Ala Thr Ile Ser Cys Arg Ser Ser Gln 
145                 150                 155                 160 
Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln 
                165                 170                 175     
Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg 
            180                 185                 190         
Phe Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             
Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 
    210                 215                 220                 
Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 
Lys Leu Glu Ile Lys Arg 
                245     

<210> 73
<211> 247
<212> PRT
<213> Artificial Sequence

<220> 
<223> scFv

<220> 
<221> SITE
<222> 136
<223> X is V or I

<220> 
<221> SITE
<222> 141
<223> X is for T or S

<220> 
<221> SITE
<222> 143
<223> X is for L or S or A

<220> 
<221> SITE
<222> 144
<223> X is for S or T

<220> 
<221> SITE
<222> 146
<223> X is for P or S

<220> 
<221> SITE
<222> 148
<223> X is for T or S

<220> 
<221> SITE
<222> 149
<223> X is for L or P

<220> 
<221> SITE
<222> 151
<223> X is for E or D

<220> 
<221> SITE
<222> 152
<223> X is for P or R

<220> 
<221> SITE
<222> 153
<223> X is for A or V

<220> 
<221> SITE
<222> 154
<223> X is for S or T

<220> 
<221> SITE
<222> 176
<223> X is for L or Q

<220> 
<221> SITE
<222> 182
<223> X is for S or A

<220> 
<221> SITE
<222> 197
<223> X is for V or I

<220> 
<221> SITE
<222> 213
<223> X is for K or T

<220> 
<221> SITE
<222> 217
<223> X is for V or L

<220> 
<221> SITE
<222> 219
<223> X is for A or P

<220> 
<221> SITE
<222> 222
<223> X is for L or F

<220> 
<221> SITE
<222> 223
<223> X is for G or A

<400> 73
Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly 
1               5                   10                  15      
Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          
Tyr His Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys 
    50                  55                  60                  
Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala 
65                  70                  75                  80  
Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Asp Xaa Val Met Thr Gln Xaa Pro Xaa Xaa 
    130                 135                 140                 
Leu Xaa Val Xaa Xaa Gly Xaa Xaa Xaa Xaa Ile Ser Cys Arg Ser Ser 
145                 150                 155                 160 
Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Xaa 
                165                 170                 175     
Gln Lys Pro Gly Gln Xaa Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn 
            180                 185                 190         
Arg Phe Ser Gly Xaa Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Phe Thr Leu Xaa Ile Ser Arg Xaa Glu Xaa Glu Asp Xaa Xaa Val 
    210                 215                 220                 
Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys Arg 
                245         

<210> 74
<211> 247
<212> PRT
<213> Artificial Sequence

<220> 
<223> scFv

<400> 74
Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly 
1               5                   10                  15      
Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          
Tyr His Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys 
    50                  55                  60                  
Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala 
65                  70                  75                  80  
Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser 
    130                 135                 140                 
Leu Pro Val Thr Leu Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser 
145                 150                 155                 160 
Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu 
                165                 170                 175     
Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn 
            180                 185                 190         
Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val 
    210                 215                 220                 
Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys Arg 
                245         

<210> 75
<211> 247
<212> PRT
<213> Artificial Sequence

<220> 
<223> scFv

<400> 75
Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly 
1               5                   10                  15      
Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          
Tyr His Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys 
    50                  55                  60                  
Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala 
65                  70                  75                  80  
Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 
Leu Ser Val Thr Leu Gly Asp Arg Val Ser Ile Ser Cys Arg Ser Ser 
145                 150                 155                 160 
Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln 
                165                 170                 175     
Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn 
            180                 185                 190         
Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Phe Thr Leu Thr Ile Ser Arg Val Glu Pro Glu Asp Leu Gly Val 
    210                 215                 220                 
Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys Arg 
                245         

<210> 76
<211> 247
<212> PRT
<213> Artificial Sequence

<220> 
<223> scFv

<400> 76
Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly 
1               5                   10                  15      
Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          
Tyr His Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys 
    50                  55                  60                  
Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala 
65                  70                  75                  80  
Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ala Thr 
    130                 135                 140                 
Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Ile Ser Cys Arg Ser Ser 
145                 150                 155                 160 
Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln 
                165                 170                 175     
Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn 
            180                 185                 190         
Arg Phe Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys Arg 
                245         

<210> 77
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> CAR

<220> 
<221> SITE
<222> 136
<223> X is for V or I

<220> 
<221> SITE
<222> 141
<223> X is for T or S

<220> 
<221> SITE
<222> 143
<223> X is for L or S or A

<220> 
<221> SITE
<222> 144
<223> X is for S or T


<220> 
<221> SITE
<222> 146
<223> X is for P or S

<220> 
<221> SITE
<222> 148
<223> X is for T or S

<220> 
<221> SITE
<222> 149
<223> X is for L or P

<220> 
<221> SITE
<222> 151
<223> X is for E or D

<220> 
<221> SITE
<222> 152
<223> X is for P or R

<220> 
<221> SITE
<222> 153
<223> X is for A or V

<220> 
<221> SITE
<222> 154
<223> X is for S or T

<220> 
<221> SITE
<222> 176
<223> X is for L or Q

<220> 
<221> SITE
<222> 182
<223> X is for S or A

<220> 
<221> SITE
<222> 197
<223> X is for V or I

<220> 
<221> SITE
<222> 213
<223> X is for K or T

<220> 
<221> SITE
<222> 217
<223> X is for V or L

<220> 
<221> SITE
<222> 219
<223> X is for A or P

<220> 
<221> SITE
<222> 222
<223> X is for L or F

<220> 
<221> SITE
<222> 223
<223> X is for G or A

<400> 77
Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly 
1               5                   10                  15      
Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          
Tyr His Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys 
    50                  55                  60                  
Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala 
65                  70                  75                  80  
Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Asp Xaa Val Met Thr Gln Xaa Pro Xaa Xaa 
    130                 135                 140                 
Leu Xaa Val Xaa Xaa Gly Xaa Xaa Xaa Xaa Ile Ser Cys Arg Ser Ser 
145                 150                 155                 160 
Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Xaa 
                165                 170                 175     
Gln Lys Pro Gly Gln Xaa Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn 
            180                 185                 190         
Arg Phe Ser Gly Xaa Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Phe Thr Leu Xaa Ile Ser Arg Xaa Glu Xaa Glu Asp Xaa Xaa Val 
    210                 215                 220                 
Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys Arg Arg Thr Thr Thr Pro Ala Pro Arg Pro 
                245                 250                 255     
Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
            260                 265                 270         
Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
        275                 280                 285             
Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
    290                 295                 300                 
Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
305                 310                 315                 320 
Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                325                 330                 335     
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            340                 345                 350         
Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
        355                 360                 365             
Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    370                 375                 380                 
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
385                 390                 395                 400 
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                405                 410                 415     
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            420                 425                 430         
Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        435                 440                 445             
Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    450                 455                 460                 
Met Gln Ala Leu Pro Pro Arg 
465                 470     

<210> 78
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> CAR

<400> 78
Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly 
1               5                   10                  15      
Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          
Tyr His Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys 
    50                  55                  60                  
Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala 
65                  70                  75                  80  
Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser 
    130                 135                 140                 
Leu Pro Val Thr Leu Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser 
145                 150                 155                 160 
Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu 
                165                 170                 175     
Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn 
            180                 185                 190         
Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val 
    210                 215                 220                 
Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys Arg Arg Thr Thr Thr Pro Ala Pro Arg Pro 
                245                 250                 255     
Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
            260                 265                 270         
Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
        275                 280                 285             
Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
    290                 295                 300                 
Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
305                 310                 315                 320 
Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                325                 330                 335     
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            340                 345                 350         
Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
        355                 360                 365             
Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    370                 375                 380                 
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
385                 390                 395                 400 
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                405                 410                 415     
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            420                 425                 430         
Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        435                 440                 445             
Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    450                 455                 460                 
Met Gln Ala Leu Pro Pro Arg 
465                 470     

<210> 79
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> CAR

<400> 79
Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly 
1               5                   10                  15      
Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          
Tyr His Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys 
    50                  55                  60                  
Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala 
65                  70                  75                  80  
Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 
Leu Ser Val Thr Leu Gly Asp Arg Val Ser Ile Ser Cys Arg Ser Ser 
145                 150                 155                 160 
Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln 
                165                 170                 175     
Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn 
            180                 185                 190         
Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Phe Thr Leu Thr Ile Ser Arg Val Glu Pro Glu Asp Leu Gly Val 
    210                 215                 220                 
Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys Arg Arg Thr Thr Thr Pro Ala Pro Arg Pro 
                245                 250                 255     
Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
            260                 265                 270         
Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
        275                 280                 285             
Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
    290                 295                 300                 
Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
305                 310                 315                 320 
Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                325                 330                 335     
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            340                 345                 350         
Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
        355                 360                 365             
Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    370                 375                 380                 
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
385                 390                 395                 400 
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                405                 410                 415     
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            420                 425                 430         
Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        435                 440                 445             
Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    450                 455                 460                 
Met Gln Ala Leu Pro Pro Arg 
465                 470     

<210> 80
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> CAR

<400> 80
Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly 
1               5                   10                  15      
Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          
Tyr His Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys 
    50                  55                  60                  
Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala 
65                  70                  75                  80  
Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ala Thr 
    130                 135                 140                 
Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Ile Ser Cys Arg Ser Ser 
145                 150                 155                 160 
Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln 
                165                 170                 175     
Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn 
            180                 185                 190         
Arg Phe Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys Arg Arg Thr Thr Thr Pro Ala Pro Arg Pro 
                245                 250                 255     
Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
            260                 265                 270         
Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
        275                 280                 285             
Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
    290                 295                 300                 
Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
305                 310                 315                 320 
Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                325                 330                 335     
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            340                 345                 350         
Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
        355                 360                 365             
Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    370                 375                 380                 
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
385                 390                 395                 400 
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                405                 410                 415     
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            420                 425                 430         
Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        435                 440                 445             
Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    450                 455                 460                 
Met Gln Ala Leu Pro Pro Arg 
465                 470     

<210> 81
<211> 492
<212> PRT
<213> Artificial Sequence

<220> 
<223> CAR

<220> 
<221> SITE
<222> 157
<223> X is for V or I

<220> 
<221> SITE
<222> 162
<223> X is for T or S

<220> 
<221> SITE
<222> 164
<223> X is for L or S or A

<220> 
<221> SITE
<222> 165
<223> X is for S or T

<220> 
<221> SITE
<222> 167
<223> X is for P or S

<220> 
<221> SITE
<222> 169
<223> X is for T or S

<220> 
<221> SITE
<222> 170
<223> X is for L or P

<220> 
<221> SITE
<222> 172
<223> X is for E or D

<220> 
<221> SITE
<222> 173
<223> X is for P or R

<220> 
<221> SITE
<222> 174
<223> X is for A or V

<220> 
<221> SITE
<222> 175
<223> X is for S or T

<220> 
<221> SITE
<222> 197
<223> X is for L or Q

<220> 
<221> SITE
<222> 203
<223> X is for S or A

<220> 
<221> SITE
<222> 218
<223> X is for V or I

<220> 
<221> SITE
<222> 234
<223> X is for Kor T

<220> 
<221> SITE
<222> 238
<223> X is for V or L

<220> 
<221> SITE
<222> 240
<223> X is for A or P

<220> 
<221> SITE
<222> 243
<223> X is for L or F

<220> 
<221> SITE
<222> 244
<223> X is for G or A

<400> 81
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      
His Ala Ala Arg Pro Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu 
            20                  25                  30          
Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              
Tyr Thr Phe Thr Ser Tyr His Ile Gln Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  
Gln Gly Leu Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr 
65                  70                  75                  80  
Gln Tyr Asn Glu Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys 
                85                  90                  95      
Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp 
            100                 105                 110         
Thr Ala Val Tyr Tyr Cys Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp 
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Xaa Val Met Thr 
145                 150                 155                 160 
Gln Xaa Pro Xaa Xaa Leu Xaa Val Xaa Xaa Gly Xaa Xaa Xaa Xaa Ile 
                165                 170                 175     
Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr 
            180                 185                 190         
Leu Glu Trp Tyr Xaa Gln Lys Pro Gly Gln Xaa Pro Arg Leu Leu Ile 
        195                 200                 205             
Tyr Lys Val Ser Asn Arg Phe Ser Gly Xaa Pro Asp Arg Phe Ser Gly 
    210                 215                 220                 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Xaa Ile Ser Arg Xaa Glu Xaa 
225                 230                 235                 240 
Glu Asp Xaa Xaa Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg 
                245                 250                 255     
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Arg Thr Thr Thr 
            260                 265                 270         
Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             
Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 
His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 
Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     
Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         
Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             
Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 
Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 
Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     
Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         
Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             
Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 
Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 
Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         

<210> 82
<211> 492
<212> PRT
<213> Artificial Sequence

<220> 
<223> CAR

<400> 82
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      
His Ala Ala Arg Pro Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu 
            20                  25                  30          
Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              
Tyr Thr Phe Thr Ser Tyr His Ile Gln Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  
Gln Gly Leu Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr 
65                  70                  75                  80  
Gln Tyr Asn Glu Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys 
                85                  90                  95      
Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp 
            100                 105                 110         
Thr Ala Val Tyr Tyr Cys Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp 
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr 
145                 150                 155                 160 
Gln Thr Pro Leu Ser Leu Pro Val Thr Leu Gly Glu Pro Ala Ser Ile 
                165                 170                 175     
Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr 
            180                 185                 190         
Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile 
        195                 200                 205             
Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly 
    210                 215                 220                 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
225                 230                 235                 240 
Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg 
                245                 250                 255     
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Arg Thr Thr Thr 
            260                 265                 270         
Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             
Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 
His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 
Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     
Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         
Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             
Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 
Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 
Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     
Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         
Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             
Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 
Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 
Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         

<210> 83
<211> 492
<212> PRT
<213> Artificial Sequence

<220> 
<223> CAR

<400> 83
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      
His Ala Ala Arg Pro Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu 
            20                  25                  30          
Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              
Tyr Thr Phe Thr Ser Tyr His Ile Gln Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  
Gln Gly Leu Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr 
65                  70                  75                  80  
Gln Tyr Asn Glu Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys 
                85                  90                  95      
Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp 
            100                 105                 110         
Thr Ala Val Tyr Tyr Cys Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp 
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr 
145                 150                 155                 160 
Gln Ser Pro Ser Ser Leu Ser Val Thr Leu Gly Asp Arg Val Ser Ile 
                165                 170                 175     
Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr 
            180                 185                 190         
Leu Glu Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile 
        195                 200                 205             
Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly 
    210                 215                 220                 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Val Glu Pro 
225                 230                 235                 240 
Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg 
                245                 250                 255     
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Arg Thr Thr Thr 
            260                 265                 270         
Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             
Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 
His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 
Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     
Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         
Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             
Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 
Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 
Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     
Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         
Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             
Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 
Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 
Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         

<210> 84
<211> 492
<212> PRT
<213> Artificial Sequence

<220> 
<223> CAR

<400> 84
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      
His Ala Ala Arg Pro Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu 
            20                  25                  30          
Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              
Tyr Thr Phe Thr Ser Tyr His Ile Gln Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  
Gln Gly Leu Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr 
65                  70                  75                  80  
Gln Tyr Asn Glu Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys 
                85                  90                  95      
Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp 
            100                 105                 110         
Thr Ala Val Tyr Tyr Cys Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp 
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
145                 150                 155                 160 
Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Ile 
                165                 170                 175     
Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr 
            180                 185                 190         
Leu Glu Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        195                 200                 205             
Tyr Lys Val Ser Asn Arg Phe Ser Gly Ile Pro Asp Arg Phe Ser Gly 
    210                 215                 220                 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
225                 230                 235                 240 
Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg 
                245                 250                 255     
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Arg Thr Thr Thr 
            260                 265                 270         
Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             
Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 
His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 
Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     
Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         
Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             
Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 
Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 
Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     
Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         
Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             
Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 
Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 
Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         

<210> 85
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> LAGLIDADG motif

<400> 85
Leu Ala Gly Leu Ile Asp Ala Asp Gly 
1               5                   

<210> 86
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> VH

<400> 86
caggtccagc tagtacaaag cggccctgaa gtaaagaaac ctggtgcctc tgtgaaggtg      60
agctgcaagg ccagcggcta caccttcacc agctaccaca tccagtgggt tcgacaggcc     120
cctggacagg gactagagtg gatcggctgg atctatcctg gcgacggcag cacccagtac     180
aacgagaagt tcaagggcag agttaccatc accgccgaca agagcaccag cacagcctat     240
atggagctga gcagcctgac cagcgaggac acagctgttt actattgtgc cagagagggc     300
acctactacg caatggatta ttggggccag gggaccagcg tgaccgtttc ttct           354

<210> 87
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> VL

<400> 87
gatgttgtaa tgacccagac acctctgagc ctgcctgtga ccctgggaga accagcatcc      60
atcagctgtc ggagcagcca gagcatcgtt cacagcaacg gcaacaccta cctggaatgg     120
tatctacaga agcccggaca gagccccagg ctgctgatct acaaggtgtc caaccgcttc     180
agtggtgtgc ccgatagatt ttctggcagc ggctctggca ccgacttcac cctgaagatc     240
tccagagtgg aagccgagga cctgggcgtg tactactgct tccaaggcag ccatgtgcca     300
agaacctttg gtggaggcac aaagctggaa atcaagcgg                            339

<210> 88
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> VL

<400> 88
gatgttgtaa tgacccagag ccctagtagc ctgtctgtga ccctgggaga tcgagtatcc      60
atcagctgtc ggagcagcca gagcatcgtt cacagcaacg gcaacaccta cctggaatgg     120
tatcaacaga agcccggaca gagccccagg ctgctgatct acaaggtgtc caaccgcttc     180
agtggtgtgc ccgatagatt ttctggcagc ggctctggca ccgacttcac cctgacgatc     240
tccagagtgg aaccagagga cctgggcgtg tactactgct tccaaggcag ccatgtgcca     300
agaacctttg gtggaggcac aaagctggaa atcaagcgg                            339

<210> 89
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> VL

<400> 89
gatattgtaa tgacccagag ccctgcaaca ctgtctgtgt cccctggaga acgagcaaca      60
atcagctgtc ggagcagcca gagcatcgtt cacagcaacg gcaacaccta cctggaatgg     120
tatcaacaga agcccggaca ggcccccagg ctgctgatct acaaggtgtc caaccgcttc     180
agtggaatac ccgatagatt ttctggcagc ggctctggca ccgacttcac cctgacgatc     240
tccagattag aaccagagga ctttgcagtg tactactgct tccaaggcag ccatgtgcca     300
agaacctttg gtggaggcac aaagctggaa atcaagcgg                            339