                         SEQUENCE LISTING

<110>  Janssen Vaccines & Prevention B.V.
       Beth Israel Deaconess Medical Center, Inc.
 
<120>  Methods for Inducing an Immune Response Against Human 
       Immunodeficiency Virus Infection in Subjects Undergoing 
       Antiretroviral Treatment

<130>  688097-373WO 
       0300 WO 00 ORD
       2016

<150>  US 62/559,881
<151>  2017-09-18

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mos1.Env protein sequence

<400>  1

Met Arg Val Thr Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Ile Leu Met Ile Cys Ser Ala Ala Gly Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Asp Val Arg Asn Val Thr Asn Asn Ala Thr Asn Thr 
    130                 135                 140                 


Asn Ser Ser Trp Gly Glu Pro Met Glu Lys Gly Glu Ile Lys Asn Cys 
145                 150                 155                 160 


Ser Phe Asn Ile Thr Thr Ser Ile Arg Asn Lys Val Gln Lys Gln Tyr 
                165                 170                 175     


Ala Leu Phe Tyr Lys Leu Asp Val Val Pro Ile Asp Asn Asp Ser Asn 
            180                 185                 190         


Asn Thr Asn Tyr Arg Leu Ile Ser Cys Asn Thr Ser Val Ile Thr Gln 
        195                 200                 205             


Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala 
    210                 215                 220                 


Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn Gly 
225                 230                 235                 240 


Thr Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
                245                 250                 255     


Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
            260                 265                 270         


Glu Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys Thr 
        275                 280                 285             


Ile Met Val Gln Leu Asn Val Ser Val Glu Ile Asn Cys Thr Arg Pro 
    290                 295                 300                 


Asn Asn Asn Thr Arg Lys Ser Ile His Ile Gly Pro Gly Arg Ala Phe 
305                 310                 315                 320 


Tyr Thr Ala Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn 
                325                 330                 335     


Ile Ser Arg Ala Asn Trp Asn Asn Thr Leu Arg Gln Ile Val Glu Lys 
            340                 345                 350         


Leu Gly Lys Gln Phe Gly Asn Asn Lys Thr Ile Val Phe Asn His Ser 
        355                 360                 365             


Ser Gly Gly Asp Pro Glu Ile Val Met His Ser Phe Asn Cys Gly Gly 
    370                 375                 380                 


Glu Phe Phe Tyr Cys Asn Ser Thr Lys Leu Phe Asn Ser Thr Trp Thr 
385                 390                 395                 400 


Trp Asn Asn Ser Thr Trp Asn Asn Thr Lys Arg Ser Asn Asp Thr Glu 
                405                 410                 415     


Glu His Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp 
            420                 425                 430         


Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile 
        435                 440                 445             


Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly 
    450                 455                 460                 


Asn Asp Thr Ser Gly Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met 
465                 470                 475                 480 


Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile 
                485                 490                 495     


Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln 
            500                 505                 510         


Ser Glu Lys Ser Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu 
        515                 520                 525             


Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val 
    530                 535                 540                 


Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu 
545                 550                 555                 560 


Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp 
                565                 570                 575     


Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu 
            580                 585                 590         


Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile 
        595                 600                 605             


Cys Thr Thr Thr Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu 
    610                 615                 620                 


Asp Lys Ile Trp Asn Asn Met Thr Trp Met Glu Trp Glu Arg Glu Ile 
625                 630                 635                 640 


Asn Asn Tyr Thr Ser Leu Ile Tyr Thr Leu Ile Glu Glu Ser Gln Asn 
                645                 650                 655     


Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala 
            660                 665                 670         


Ser Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu Trp 
        675                 680                 685 


<210>  2
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mos2.Env protein sequence

<400>  2

Met Arg Val Arg Gly Ile Gln Arg Asn Trp Pro Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Ile Ile Ile Cys Arg Val Met Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Met Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Arg Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Glu Cys Arg Asn Val Arg Asn Val Ser Ser Asn Gly Thr Tyr Asn Ile 
    130                 135                 140                 


Ile His Asn Glu Thr Tyr Lys Glu Met Lys Asn Cys Ser Phe Asn Ala 
145                 150                 155                 160 


Thr Thr Val Val Glu Asp Arg Lys Gln Lys Val His Ala Leu Phe Tyr 
                165                 170                 175     


Arg Leu Asp Ile Val Pro Leu Asp Glu Asn Asn Ser Ser Glu Lys Ser 
            180                 185                 190         


Ser Glu Asn Ser Ser Glu Tyr Tyr Arg Leu Ile Asn Cys Asn Thr Ser 
        195                 200                 205             


Ala Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile 
    210                 215                 220                 


His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys 
225                 230                 235                 240 


Thr Phe Asn Gly Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys 
                245                 250                 255     


Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly 
            260                 265                 270         


Ser Leu Ala Glu Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn 
        275                 280                 285             


Asn Ala Lys Thr Ile Ile Val His Leu Asn Glu Thr Val Asn Ile Thr 
    290                 295                 300                 


Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro 
305                 310                 315                 320 


Gly Gln Thr Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln 
                325                 330                 335     


Ala His Cys Asn Leu Ser Arg Asp Gly Trp Asn Lys Thr Leu Gln Gly 
            340                 345                 350         


Val Lys Lys Lys Leu Ala Glu His Phe Pro Asn Lys Thr Ile Asn Phe 
        355                 360                 365             


Thr Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn 
    370                 375                 380                 


Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Gly 
385                 390                 395                 400 


Thr Tyr Met Pro Asn Gly Thr Asn Ser Asn Ser Ser Ser Asn Ile Thr 
                405                 410                 415     


Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly 
            420                 425                 430         


Arg Ala Met Tyr Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Arg Ser 
        435                 440                 445             


Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Ser Asn Asn Gly 
    450                 455                 460                 


Val Pro Asn Asp Thr Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg 
465                 470                 475                 480 


Asn Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Val Lys 
                485                 490                 495     


Pro Leu Gly Val Ala Pro Thr Glu Ala Lys Arg Arg Val Val Glu Ser 
            500                 505                 510         


Glu Lys Ser Ala Val Gly Ile Gly Ala Val Phe Leu Gly Ile Leu Gly 
        515                 520                 525             


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln 
    530                 535                 540                 


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
545                 550                 555                 560 


Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly 
                565                 570                 575     


Ile Lys Gln Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Gln 
            580                 585                 590         


Asp Gln Gln Leu Leu Gly Leu Trp Gly Cys Ser Gly Lys Leu Ile Cys 
        595                 600                 605             


Thr Thr Ala Val Pro Trp Asn Thr Ser Trp Ser Asn Lys Ser Gln Thr 
    610                 615                 620                 


Asp Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Lys Glu Ile Gly 
625                 630                 635                 640 


Asn Tyr Thr Gly Glu Ile Tyr Arg Leu Leu Glu Glu Ser Gln Asn Gln 
                645                 650                 655     


Gln Glu Lys Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys Asn 
            660                 665                 670         


Leu Trp Asn Trp Phe Asp Ile Thr Asn Trp Leu Trp 
        675                 680                 


<210>  3
<211>  1350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mos1.Gag-Pol protein sequence

<400>  3

Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Arg Leu Lys 
            20                  25                  30          


His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 
        35                  40                  45              


Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 
    50                  55                  60                  


Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 
65                  70                  75                  80  


Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp 
                85                  90                  95      


Thr Lys Glu Ala Leu Glu Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 
            100                 105                 110         


Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly Asn Ser Ser Gln Val 
        115                 120                 125             


Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 
    130                 135                 140                 


Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 
145                 150                 155                 160 


Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 
                165                 170                 175     


Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 
            180                 185                 190         


Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 
        195                 200                 205             


Ala Ala Glu Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala 
    210                 215                 220                 


Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 
225                 230                 235                 240 


Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 
                245                 250                 255     


Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 
            260                 265                 270         


Ile Val Arg Met Tyr Ser Pro Val Ser Ile Leu Asp Ile Arg Gln Gly 
        275                 280                 285             


Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 
    290                 295                 300                 


Arg Ala Glu Gln Ala Ser Gln Asp Val Lys Asn Trp Met Thr Glu Thr 
305                 310                 315                 320 


Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 
                325                 330                 335     


Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 
            340                 345                 350         


Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met Ser 
        355                 360                 365             


Gln Val Thr Asn Ser Ala Thr Ile Met Met Gln Arg Gly Asn Phe Arg 
    370                 375                 380                 


Asn Gln Arg Lys Thr Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His 
385                 390                 395                 400 


Ile Ala Lys Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys 
                405                 410                 415     


Gly Lys Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn 
            420                 425                 430         


Phe Leu Gly Lys Ile Trp Pro Ser Asn Lys Gly Arg Pro Gly Asn Phe 
        435                 440                 445             


Leu Gln Asn Arg Pro Glu Pro Thr Ala Pro Pro Glu Glu Ser Phe Arg 
    450                 455                 460                 


Phe Gly Glu Glu Thr Thr Thr Pro Ser Gln Lys Gln Glu Pro Ile Asp 
465                 470                 475                 480 


Lys Glu Met Tyr Pro Leu Ala Ser Leu Lys Ser Leu Phe Gly Asn Asp 
                485                 490                 495     


Pro Ser Ser Gln Met Ala Pro Ile Ser Pro Ile Glu Thr Val Pro Val 
            500                 505                 510         


Lys Leu Lys Pro Gly Met Asp Gly Pro Arg Val Lys Gln Trp Pro Leu 
        515                 520                 525             


Thr Glu Glu Lys Ile Lys Ala Leu Thr Ala Ile Cys Glu Glu Met Glu 
    530                 535                 540                 


Lys Glu Gly Lys Ile Thr Lys Ile Gly Pro Glu Asn Pro Tyr Asn Thr 
545                 550                 555                 560 


Pro Val Phe Ala Ile Lys Lys Lys Asp Ser Thr Lys Trp Arg Lys Leu 
                565                 570                 575     


Val Asp Phe Arg Glu Leu Asn Lys Arg Thr Gln Asp Phe Trp Glu Val 
            580                 585                 590         


Gln Leu Gly Ile Pro His Pro Ala Gly Leu Lys Lys Lys Lys Ser Val 
        595                 600                 605             


Thr Val Leu Ala Val Gly Asp Ala Tyr Phe Ser Val Pro Leu Asp Glu 
    610                 615                 620                 


Gly Phe Arg Lys Tyr Thr Ala Phe Thr Ile Pro Ser Thr Asn Asn Glu 
625                 630                 635                 640 


Thr Pro Gly Ile Arg Tyr Gln Tyr Asn Val Leu Pro Gln Gly Trp Lys 
                645                 650                 655     


Gly Ser Pro Ala Ile Phe Gln Cys Ser Met Thr Arg Ile Leu Glu Pro 
            660                 665                 670         


Phe Arg Ala Lys Asn Pro Glu Ile Val Ile Tyr Gln Tyr Met Ala Ala 
        675                 680                 685             


Leu Tyr Val Gly Ser Asp Leu Glu Ile Gly Gln His Arg Ala Lys Ile 
    690                 695                 700                 


Glu Glu Leu Arg Glu His Leu Leu Lys Trp Gly Phe Thr Thr Pro Asp 
705                 710                 715                 720 


Lys Lys His Gln Lys Glu Pro Pro Phe Leu Trp Met Gly Tyr Glu Leu 
                725                 730                 735     


His Pro Asp Lys Trp Thr Val Gln Pro Ile Gln Leu Pro Glu Lys Asp 
            740                 745                 750         


Ser Trp Thr Val Asn Asp Ile Gln Lys Leu Val Gly Lys Leu Asn Trp 
        755                 760                 765             


Ala Ser Gln Ile Tyr Pro Gly Ile Lys Val Arg Gln Leu Cys Lys Leu 
    770                 775                 780                 


Leu Arg Gly Ala Lys Ala Leu Thr Asp Ile Val Pro Leu Thr Glu Glu 
785                 790                 795                 800 


Ala Glu Leu Glu Leu Ala Glu Asn Arg Glu Ile Leu Lys Glu Pro Val 
                805                 810                 815     


His Gly Val Tyr Tyr Asp Pro Ser Lys Asp Leu Ile Ala Glu Ile Gln 
            820                 825                 830         


Lys Gln Gly His Asp Gln Trp Thr Tyr Gln Ile Tyr Gln Glu Pro Phe 
        835                 840                 845             


Lys Asn Leu Lys Thr Gly Lys Tyr Ala Lys Met Arg Thr Ala His Thr 
    850                 855                 860                 


Asn Asp Val Lys Gln Leu Thr Glu Ala Val Gln Lys Ile Ala Met Glu 
865                 870                 875                 880 


Ser Ile Val Ile Trp Gly Lys Thr Pro Lys Phe Arg Leu Pro Ile Gln 
                885                 890                 895     


Lys Glu Thr Trp Glu Thr Trp Trp Thr Asp Tyr Trp Gln Ala Thr Trp 
            900                 905                 910         


Ile Pro Glu Trp Glu Phe Val Asn Thr Pro Pro Leu Val Lys Leu Trp 
        915                 920                 925             


Tyr Gln Leu Glu Lys Asp Pro Ile Ala Gly Val Glu Thr Phe Tyr Val 
    930                 935                 940                 


Ala Gly Ala Ala Asn Arg Glu Thr Lys Leu Gly Lys Ala Gly Tyr Val 
945                 950                 955                 960 


Thr Asp Arg Gly Arg Gln Lys Ile Val Ser Leu Thr Glu Thr Thr Asn 
                965                 970                 975     


Gln Lys Thr Ala Leu Gln Ala Ile Tyr Leu Ala Leu Gln Asp Ser Gly 
            980                 985                 990         


Ser Glu Val Asn Ile Val Thr Ala  Ser Gln Tyr Ala Leu  Gly Ile Ile 
        995                 1000                 1005             


Gln Ala  Gln Pro Asp Lys Ser  Glu Ser Glu Leu Val  Asn Gln Ile 
    1010                 1015                 1020             


Ile Glu  Gln Leu Ile Lys Lys  Glu Arg Val Tyr Leu  Ser Trp Val 
    1025                 1030                 1035             


Pro Ala  His Lys Gly Ile Gly  Gly Asn Glu Gln Val  Asp Lys Leu 
    1040                 1045                 1050             


Val Ser  Ser Gly Ile Arg Lys  Val Leu Phe Leu Asp  Gly Ile Asp 
    1055                 1060                 1065             


Lys Ala  Gln Glu Glu His Glu  Lys Tyr His Ser Asn  Trp Arg Ala 
    1070                 1075                 1080             


Met Ala  Ser Asp Phe Asn Leu  Pro Pro Val Val Ala  Lys Glu Ile 
    1085                 1090                 1095             


Val Ala  Ser Cys Asp Gln Cys  Gln Leu Lys Gly Glu  Ala Met His 
    1100                 1105                 1110             


Gly Gln  Val Asp Cys Ser Pro  Gly Ile Trp Gln Leu  Ala Cys Thr 
    1115                 1120                 1125             


His Leu  Glu Gly Lys Ile Ile  Leu Val Ala Val His  Val Ala Ser 
    1130                 1135                 1140             


Gly Tyr  Ile Glu Ala Glu Val  Ile Pro Ala Glu Thr  Gly Gln Glu 
    1145                 1150                 1155             


Thr Ala  Tyr Phe Ile Leu Lys  Leu Ala Gly Arg Trp  Pro Val Lys 
    1160                 1165                 1170             


Val Ile  His Thr Ala Asn Gly  Ser Asn Phe Thr Ser  Ala Ala Val 
    1175                 1180                 1185             


Lys Ala  Ala Cys Trp Trp Ala  Gly Ile Gln Gln Glu  Phe Gly Ile 
    1190                 1195                 1200             


Pro Tyr  Asn Pro Gln Ser Gln  Gly Val Val Ala Ser  Met Asn Lys 
    1205                 1210                 1215             


Glu Leu  Lys Lys Ile Ile Gly  Gln Val Arg Asp Gln  Ala Glu His 
    1220                 1225                 1230             


Leu Lys  Thr Ala Val Gln Met  Ala Val Phe Ile His  Asn Phe Lys 
    1235                 1240                 1245             


Arg Lys  Gly Gly Ile Gly Gly  Tyr Ser Ala Gly Glu  Arg Ile Ile 
    1250                 1255                 1260             


Asp Ile  Ile Ala Thr Asp Ile  Gln Thr Lys Glu Leu  Gln Lys Gln 
    1265                 1270                 1275             


Ile Ile  Lys Ile Gln Asn Phe  Arg Val Tyr Tyr Arg  Asp Ser Arg 
    1280                 1285                 1290             


Asp Pro  Ile Trp Lys Gly Pro  Ala Lys Leu Leu Trp  Lys Gly Glu 
    1295                 1300                 1305             


Gly Ala  Val Val Ile Gln Asp  Asn Ser Asp Ile Lys  Val Val Pro 
    1310                 1315                 1320             


Arg Arg  Lys Val Lys Ile Ile  Lys Asp Tyr Gly Lys  Gln Met Ala 
    1325                 1330                 1335             


Gly Ala  Asp Cys Val Ala Gly  Arg Gln Asp Glu Asp  
    1340                 1345                 1350 


<210>  4
<211>  1341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mos2.Gag-Pol protein sequence

<400>  4

Met Gly Ala Arg Ala Ser Ile Leu Arg Gly Gly Lys Leu Asp Lys Trp 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys His Tyr Met Leu Lys 
            20                  25                  30          


His Leu Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Leu Asn Pro 
        35                  40                  45              


Gly Leu Leu Glu Thr Ser Glu Gly Cys Lys Gln Ile Ile Lys Gln Leu 
    50                  55                  60                  


Gln Pro Ala Leu Gln Thr Gly Thr Glu Glu Leu Arg Ser Leu Phe Asn 
65                  70                  75                  80  


Thr Val Ala Thr Leu Tyr Cys Val His Ala Glu Ile Glu Val Arg Asp 
                85                  90                  95      


Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Gln 
            100                 105                 110         


Gln Lys Thr Gln Gln Ala Lys Glu Ala Asp Gly Lys Val Ser Gln Asn 
        115                 120                 125             


Tyr Pro Ile Val Gln Asn Leu Gln Gly Gln Met Val His Gln Pro Ile 
    130                 135                 140                 


Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Ile Glu Glu Lys Ala 
145                 150                 155                 160 


Phe Ser Pro Glu Val Ile Pro Met Phe Thr Ala Leu Ser Glu Gly Ala 
                165                 170                 175     


Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly Gly His Gln 
            180                 185                 190         


Ala Ala Met Gln Met Leu Lys Asp Thr Ile Asn Glu Glu Ala Ala Glu 
        195                 200                 205             


Trp Asp Arg Leu His Pro Val His Ala Gly Pro Val Ala Pro Gly Gln 
    210                 215                 220                 


Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr Ser Asn Leu 
225                 230                 235                 240 


Gln Glu Gln Ile Ala Trp Met Thr Ser Asn Pro Pro Ile Pro Val Gly 
                245                 250                 255     


Asp Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg 
            260                 265                 270         


Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Lys Gln Gly Pro Lys Glu 
        275                 280                 285             


Pro Phe Arg Asp Tyr Val Asp Arg Phe Phe Lys Thr Leu Arg Ala Glu 
    290                 295                 300                 


Gln Ala Thr Gln Asp Val Lys Asn Trp Met Thr Asp Thr Leu Leu Val 
305                 310                 315                 320 


Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Arg Ala Leu Gly Pro 
                325                 330                 335     


Gly Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly Val Gly Gly 
            340                 345                 350         


Pro Ser His Lys Ala Arg Val Leu Ala Glu Ala Met Ser Gln Thr Asn 
        355                 360                 365             


Ser Thr Ile Leu Met Gln Arg Ser Asn Phe Lys Gly Ser Lys Arg Ile 
    370                 375                 380                 


Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His Ile Ala Arg Asn Cys 
385                 390                 395                 400 


Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys Gly Lys Glu Gly His 
                405                 410                 415     


Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn Phe Leu Gly Lys Ile 
            420                 425                 430         


Trp Pro Ser His Lys Gly Arg Pro Gly Asn Phe Leu Gln Ser Arg Pro 
        435                 440                 445             


Glu Pro Thr Ala Pro Pro Ala Glu Ser Phe Arg Phe Glu Glu Thr Thr 
    450                 455                 460                 


Pro Ala Pro Lys Gln Glu Pro Lys Asp Arg Glu Pro Leu Thr Ser Leu 
465                 470                 475                 480 


Arg Ser Leu Phe Gly Ser Asp Pro Leu Ser Gln Met Ala Pro Ile Ser 
                485                 490                 495     


Pro Ile Glu Thr Val Pro Val Lys Leu Lys Pro Gly Met Asp Gly Pro 
            500                 505                 510         


Lys Val Lys Gln Trp Pro Leu Thr Glu Glu Lys Ile Lys Ala Leu Val 
        515                 520                 525             


Glu Ile Cys Thr Glu Met Glu Lys Glu Gly Lys Ile Ser Lys Ile Gly 
    530                 535                 540                 


Pro Glu Asn Pro Tyr Asn Thr Pro Ile Phe Ala Ile Lys Lys Lys Asp 
545                 550                 555                 560 


Ser Thr Lys Trp Arg Lys Leu Val Asp Phe Arg Glu Leu Asn Lys Arg 
                565                 570                 575     


Thr Gln Asp Phe Trp Glu Val Gln Leu Gly Ile Pro His Pro Ala Gly 
            580                 585                 590         


Leu Lys Lys Lys Lys Ser Val Thr Val Leu Ala Val Gly Asp Ala Tyr 
        595                 600                 605             


Phe Ser Val Pro Leu Asp Glu Asp Phe Arg Lys Tyr Thr Ala Phe Thr 
    610                 615                 620                 


Ile Pro Ser Ile Asn Asn Glu Thr Pro Gly Ile Arg Tyr Gln Tyr Asn 
625                 630                 635                 640 


Val Leu Pro Gln Gly Trp Lys Gly Ser Pro Ala Ile Phe Gln Ser Ser 
                645                 650                 655     


Met Thr Lys Ile Leu Glu Pro Phe Arg Lys Gln Asn Pro Asp Ile Val 
            660                 665                 670         


Ile Tyr Gln Tyr Met Ala Ala Leu Tyr Val Gly Ser Asp Leu Glu Ile 
        675                 680                 685             


Gly Gln His Arg Thr Lys Ile Glu Glu Leu Arg Gln His Leu Leu Arg 
    690                 695                 700                 


Trp Gly Phe Thr Thr Pro Asp Lys Lys His Gln Lys Glu Pro Pro Phe 
705                 710                 715                 720 


Leu Trp Met Gly Tyr Glu Leu His Pro Asp Lys Trp Thr Val Gln Pro 
                725                 730                 735     


Ile Val Leu Pro Glu Lys Asp Ser Trp Thr Val Asn Asp Ile Gln Lys 
            740                 745                 750         


Leu Val Gly Lys Leu Asn Trp Ala Ser Gln Ile Tyr Ala Gly Ile Lys 
        755                 760                 765             


Val Lys Gln Leu Cys Lys Leu Leu Arg Gly Thr Lys Ala Leu Thr Glu 
    770                 775                 780                 


Val Val Pro Leu Thr Glu Glu Ala Glu Leu Glu Leu Ala Glu Asn Arg 
785                 790                 795                 800 


Glu Ile Leu Lys Glu Pro Val His Gly Val Tyr Tyr Asp Pro Ser Lys 
                805                 810                 815     


Asp Leu Ile Ala Glu Ile Gln Lys Gln Gly Gln Gly Gln Trp Thr Tyr 
            820                 825                 830         


Gln Ile Tyr Gln Glu Pro Phe Lys Asn Leu Lys Thr Gly Lys Tyr Ala 
        835                 840                 845             


Arg Met Arg Gly Ala His Thr Asn Asp Val Lys Gln Leu Thr Glu Ala 
    850                 855                 860                 


Val Gln Lys Ile Ala Thr Glu Ser Ile Val Ile Trp Gly Lys Thr Pro 
865                 870                 875                 880 


Lys Phe Lys Leu Pro Ile Gln Lys Glu Thr Trp Glu Ala Trp Trp Thr 
                885                 890                 895     


Glu Tyr Trp Gln Ala Thr Trp Ile Pro Glu Trp Glu Phe Val Asn Thr 
            900                 905                 910         


Pro Pro Leu Val Lys Leu Trp Tyr Gln Leu Glu Lys Glu Pro Ile Val 
        915                 920                 925             


Gly Ala Glu Thr Phe Tyr Val Ala Gly Ala Ala Asn Arg Glu Thr Lys 
    930                 935                 940                 


Leu Gly Lys Ala Gly Tyr Val Thr Asp Arg Gly Arg Gln Lys Val Val 
945                 950                 955                 960 


Ser Leu Thr Asp Thr Thr Asn Gln Lys Thr Ala Leu Gln Ala Ile His 
                965                 970                 975     


Leu Ala Leu Gln Asp Ser Gly Leu Glu Val Asn Ile Val Thr Ala Ser 
            980                 985                 990         


Gln Tyr Ala Leu Gly Ile Ile Gln  Ala Gln Pro Asp Lys  Ser Glu Ser 
        995                 1000                 1005             


Glu Leu  Val Ser Gln Ile Ile  Glu Gln Leu Ile Lys  Lys Glu Lys 
    1010                 1015                 1020             


Val Tyr  Leu Ala Trp Val Pro  Ala His Lys Gly Ile  Gly Gly Asn 
    1025                 1030                 1035             


Glu Gln  Val Asp Lys Leu Val  Ser Arg Gly Ile Arg  Lys Val Leu 
    1040                 1045                 1050             


Phe Leu  Asp Gly Ile Asp Lys  Ala Gln Glu Glu His  Glu Lys Tyr 
    1055                 1060                 1065             


His Ser  Asn Trp Arg Ala Met  Ala Ser Glu Phe Asn  Leu Pro Pro 
    1070                 1075                 1080             


Ile Val  Ala Lys Glu Ile Val  Ala Ser Cys Asp Lys  Cys Gln Leu 
    1085                 1090                 1095             


Lys Gly  Glu Ala Ile His Gly  Gln Val Asp Cys Ser  Pro Gly Ile 
    1100                 1105                 1110             


Trp Gln  Leu Ala Cys Thr His  Leu Glu Gly Lys Val  Ile Leu Val 
    1115                 1120                 1125             


Ala Val  His Val Ala Ser Gly  Tyr Ile Glu Ala Glu  Val Ile Pro 
    1130                 1135                 1140             


Ala Glu  Thr Gly Gln Glu Thr  Ala Tyr Phe Leu Leu  Lys Leu Ala 
    1145                 1150                 1155             


Gly Arg  Trp Pro Val Lys Thr  Ile His Thr Ala Asn  Gly Ser Asn 
    1160                 1165                 1170             


Phe Thr  Ser Ala Thr Val Lys  Ala Ala Cys Trp Trp  Ala Gly Ile 
    1175                 1180                 1185             


Lys Gln  Glu Phe Gly Ile Pro  Tyr Asn Pro Gln Ser  Gln Gly Val 
    1190                 1195                 1200             


Val Ala  Ser Ile Asn Lys Glu  Leu Lys Lys Ile Ile  Gly Gln Val 
    1205                 1210                 1215             


Arg Asp  Gln Ala Glu His Leu  Lys Thr Ala Val Gln  Met Ala Val 
    1220                 1225                 1230             


Phe Ile  His Asn Phe Lys Arg  Lys Gly Gly Ile Gly  Glu Tyr Ser 
    1235                 1240                 1245             


Ala Gly  Glu Arg Ile Val Asp  Ile Ile Ala Ser Asp  Ile Gln Thr 
    1250                 1255                 1260             


Lys Glu  Leu Gln Lys Gln Ile  Thr Lys Ile Gln Asn  Phe Arg Val 
    1265                 1270                 1275             


Tyr Tyr  Arg Asp Ser Arg Asp  Pro Leu Trp Lys Gly  Pro Ala Lys 
    1280                 1285                 1290             


Leu Leu  Trp Lys Gly Glu Gly  Ala Val Val Ile Gln  Asp Asn Ser 
    1295                 1300                 1305             


Asp Ile  Lys Val Val Pro Arg  Arg Lys Ala Lys Ile  Ile Arg Asp 
    1310                 1315                 1320             


Tyr Gly  Lys Gln Met Ala Gly  Asp Asp Cys Val Ala  Ser Arg Gln 
    1325                 1330                 1335             


Asp Glu  Asp 
    1340     


<210>  5
<211>  2055
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mos1.Env DNA

<400>  5
atgcgggtga ccggcatccg gaagaactac cagcacctgt ggcggtgggg caccatgctg       60

ctgggcatcc tgatgatttg ctctgccgcc ggaaagctgt gggtgaccgt gtactacggc      120

gtgcccgtgt ggaaagaggc caccaccacc ctgttctgcg ccagcgacgc caaggcctac      180

gacaccgagg tgcacaacgt gtgggccacc cacgcctgcg tgcccaccga ccccaacccc      240

caggaagtgg tcctggaaaa cgtgaccgag aacttcaaca tgtggaagaa caacatggtg      300

gagcagatgc acgaggacat catcagcctg tgggaccaga gcctgaagcc ctgcgtgaag      360

ctgacccccc tgtgcgtgac cctgaactgc accgacgacg tgcggaacgt gaccaacaac      420

gccaccaaca ccaacagcag ctggggcgag cctatggaaa agggcgagat caagaactgc      480

agcttcaaca tcaccacctc catccggaac aaggtgcaga agcagtacgc cctgttctac      540

aagctggacg tggtgcccat cgacaacgac agcaacaaca ccaactaccg gctgatcagc      600

tgcaacacca gcgtgatcac ccaggcctgc cccaaggtgt ccttcgagcc catccccatc      660

cactactgcg cccctgccgg cttcgccatc ctgaagtgca acgacaagaa gttcaacggc      720

accggcccct gcaccaacgt gagcaccgtg cagtgcaccc acggcatccg gcccgtggtg      780

tccacccagc tgctgctgaa cggcagcctg gccgaggaag aggtggtgat cagaagcgag      840

aatttcacca acaatgccaa gaccatcatg gtgcagctga acgtgagcgt ggagatcaac      900

tgcacccggc ccaacaacaa cacccggaag agcatccaca tcggccctgg cagggccttc      960

tacacagccg gcgacatcat cggcgacatc cggcaggccc actgcaacat cagccgggcc     1020

aactggaaca acaccctgcg gcagatcgtg gagaagctgg gcaagcagtt cggcaacaac     1080

aagaccatcg tgttcaacca cagcagcggc ggagaccccg agatcgtgat gcacagcttc     1140

aactgtggcg gcgagttctt ctactgcaac agcaccaagc tgttcaacag cacctggacc     1200

tggaacaact ccacctggaa taacaccaag cggagcaacg acaccgaaga gcacatcacc     1260

ctgccctgcc ggatcaagca gattatcaat atgtggcagg aggtcggcaa ggccatgtac     1320

gcccctccca tccggggcca gatccggtgc agcagcaaca tcaccggcct gctgctgacc     1380

cgggacggcg gcaacgatac cagcggcacc gagatcttcc ggcctggcgg cggagatatg     1440

cgggacaact ggcggagcga gctgtacaag tacaaggtgg tgaagatcga gcccctgggc     1500

gtggctccca ccaaggccaa gcggcgggtg gtgcagagcg agaagagcgc cgtgggcatc     1560

ggcgccgtgt ttctgggctt cctgggagcc gccggaagca ccatgggagc cgccagcatg     1620

accctgaccg tgcaggcccg gctgctgctg tccggcatcg tgcagcagca gaacaacctg     1680

ctccgggcca tcgaggccca gcagcacctg ctgcagctga ccgtgtgggg catcaagcag     1740

ctgcaggcca gggtgctggc cgtggagaga tacctgaagg atcagcagct cctggggatc     1800

tggggctgca gcggcaagct gatctgcacc accaccgtgc cctggaacgc cagctggtcc     1860

aacaagagcc tggacaagat ctggaacaat atgacctgga tggaatggga gcgcgagatc     1920

aacaattaca ccagcctgat ctacaccctg atcgaggaaa gccagaacca gcaggaaaag     1980

aacgagcagg aactgctgga actggacaag tgggccagcc tgtggaactg gttcgacatc     2040

agcaactggc tgtgg                                                      2055


<210>  6
<211>  2052
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mos2.Env DNA

<400>  6
atgagagtgc ggggcatcca gcggaactgg ccccagtggt ggatctgggg catcctgggc       60

ttttggatga tcatcatctg ccgggtgatg ggcaacctgt gggtgaccgt gtactacggc      120

gtgcccgtgt ggaaagaggc caagaccacc ctgttctgcg ccagcgacgc caaggcctac      180

gagaaagagg tgcacaacgt gtgggccacc cacgcctgcg tgcccaccga ccccaacccc      240

caggaaatgg tcctggaaaa cgtgaccgag aacttcaaca tgtggaagaa cgacatggtg      300

gaccagatgc acgaggacat catccggctg tgggaccaga gcctgaagcc ctgcgtgaag      360

ctgacccccc tgtgcgtgac cctggaatgc cggaacgtga gaaacgtgag cagcaacggc      420

acctacaaca tcatccacaa cgagacctac aaagagatga agaactgcag cttcaacgcc      480

accaccgtgg tggaggaccg gaagcagaag gtgcacgccc tgttctaccg gctggacatc      540

gtgcccctgg acgagaacaa cagcagcgag aagtccagcg agaacagctc cgagtactac      600

cggctgatca actgcaacac cagcgccatc acccaggcct gccccaaggt gtccttcgac      660

cccatcccca tccactactg cgcccctgcc ggctacgcca tcctgaagtg caacaacaag      720

accttcaacg gcaccggccc ctgcaacaac gtgagcaccg tgcagtgcac ccacggcatc      780

aagcccgtgg tgtccaccca gctgctgctg aacggcagcc tggccgagga agagatcatc      840

atccggtccg agaacctgac caacaacgcc aagaccatca tcgtgcacct gaatgagacc      900

gtgaacatca cctgcacccg gcccaacaac aacacccgga agagcatccg gatcggccct      960

ggccagacct tttacgccac cggcgacatc atcggcgaca tccggcaggc ccactgcaac     1020

ctgagccggg acggctggaa caagaccctg cagggcgtga agaagaagct ggccgagcac     1080

ttccccaata agaccatcaa cttcaccagc agcagcggcg gagacctgga aatcaccacc     1140

cacagcttca actgcagggg cgagttcttc tactgcaata cctccggcct gttcaatggc     1200

acctacatgc ccaacggcac caacagcaac agcagcagca acatcaccct gccctgccgg     1260

atcaagcaga tcatcaatat gtggcaggag gtcggcaggg ccatgtacgc ccctcccatc     1320

gccggcaata tcacctgccg gtccaacatc accggcctgc tgctgaccag ggacggcggc     1380

agcaacaacg gcgtgcctaa cgacaccgag accttccggc ctggcggcgg agatatgcgg     1440

aacaactggc ggagcgagct gtacaagtac aaggtggtgg aggtgaagcc cctgggcgtg     1500

gctcctaccg aggccaagcg gcgggtggtg gagagcgaga agagcgccgt gggcatcggc     1560

gccgtgtttc tgggcattct gggagccgcc ggaagcacca tgggagccgc cagcatcacc     1620

ctgaccgtgc aggcccggca gctgctgtcc ggcatcgtgc agcagcagag caacctgctg     1680

agagccatcg aggcccagca gcacatgctg cagctgaccg tgtggggcat caagcagctg     1740

cagacccggg tgctggccat cgagagatac ctgcaggatc agcagctcct gggcctgtgg     1800

ggctgcagcg gcaagctgat ctgcaccacc gccgtgccct ggaacaccag ctggtccaac     1860

aagagccaga ccgacatctg ggacaacatg acctggatgc agtgggacaa agagatcggc     1920

aactacaccg gcgagatcta caggctgctg gaagagagcc agaaccagca ggaaaagaac     1980

gagaaggacc tgctggccct ggacagctgg aagaacctgt ggaactggtt cgacatcacc     2040

aactggctgt gg                                                         2052


<210>  7
<211>  4050
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mos1.Gag-Pol DNA

<400>  7
atgggagcca gagccagcgt gctgtccgga ggggagctgg accgctggga gaagatcagg       60

ctgaggcctg gagggaagaa gaagtacagg ctgaagcaca tcgtgtgggc cagcagagag      120

ctggaacggt ttgccgtgaa ccctggcctg ctggaaacca gcgagggctg taggcagatt      180

ctgggacagc tgcagcccag cctgcagaca ggcagcgagg aactgcggag cctgtacaac      240

accgtggcca ccctgtactg cgtgcaccag cggatcgaga tcaaggacac caaagaagcc      300

ctggaaaaga tcgaggaaga gcagaacaag agcaagaaga aagcccagca ggctgccgct      360

gacacaggca acagcagcca ggtgtcccag aactacccca tcgtgcagaa catccaggga      420

cagatggtgc accaggccat cagccctcgg accctgaacg cctgggtgaa ggtggtggag      480

gaaaaggcct tcagccctga ggtgatcccc atgttctctg ccctgagcga gggagccaca      540

ccccaggacc tgaacaccat gctgaacacc gtgggagggc accaggctgc catgcagatg      600

ctgaaagaga caatcaacga ggaagctgcc gagtgggaca gggtccaccc agtgcacgct      660

ggacctatcg ctcctggcca gatgagagag cccagaggca gcgatattgc tggcaccacc      720

tccacactgc aggaacagat cggctggatg accaacaacc ctcccatccc tgtgggagag      780

atctacaagc ggtggatcat tctgggactg aacaagatcg tgcggatgta cagccctgtg      840

agcatcctgg acatcaggca gggacccaaa gagcccttca gggactacgt ggaccggttc      900

tacaagaccc tgagagccga gcaggccagc caggacgtga agaactggat gaccgagaca      960

ctgctggtgc agaacgccaa ccctgactgc aagaccatcc tgaaagccct gggacctgct     1020

gccaccctgg aagagatgat gacagcctgc cagggagtgg gaggacctgg ccacaaggcc     1080

agggtgctgg ccgaggccat gagccaggtg accaactctg ccaccatcat gatgcagaga     1140

ggcaacttcc ggaaccagag aaagaccgtg aagtgcttca actgtggcaa agagggacac     1200

attgccaaga actgcagggc tcccaggaag aaaggctgct ggaagtgcgg aaaagaaggc     1260

caccagatga aggactgcac cgagaggcag gccaacttcc tgggcaagat ctggcctagc     1320

aacaagggca ggcctggcaa cttcctgcag aacagacccg agcccaccgc tcctcccgag     1380

gaaagcttcc ggtttggcga ggaaaccacc acccctagcc agaagcagga acccatcgac     1440

aaagagatgt accctctggc cagcctgaag agcctgttcg gcaacgaccc cagcagccag     1500

atggctccca tcagcccaat cgagacagtg cctgtgaagc tgaagcctgg catggacgga     1560

cccagggtga agcagtggcc tctgaccgag gaaaagatca aagccctgac agccatctgc     1620

gaggaaatgg aaaaagaggg caagatcacc aagatcggac ccgagaaccc ctacaacacc     1680

cctgtgttcg ccatcaagaa gaaagacagc accaagtgga ggaaactggt ggacttcaga     1740

gagctgaaca agcggaccca ggacttctgg gaggtgcagc tgggcatccc tcaccctgct     1800

ggcctgaaga aaaagaaaag cgtgaccgtg ctggctgtgg gagatgccta cttcagcgtg     1860

cctctggacg agggcttccg gaagtacaca gccttcacca tccccagcac caacaacgag     1920

acacctggca tcagatacca gtacaacgtg ctgcctcagg gctggaaagg cagccctgcc     1980

atcttccagt gcagcatgac cagaatcctg gaacccttca gagccaagaa ccctgagatc     2040

gtgatctacc agtatatggc tgccctctac gtgggcagcg acctggaaat cggacagcac     2100

agagccaaaa tcgaagaact ccgcgagcac ctgctgaagt ggggattcac cacccctgac     2160

aagaagcacc agaaagagcc tcccttcctg tggatgggct acgagctgca ccctgacaag     2220

tggaccgtgc agcccatcca gctgccagag aaggactcct ggaccgtgaa cgacatccag     2280

aaactggtcg gcaagctgaa ctgggccagc cagatctacc ctggcatcaa agtcagacag     2340

ctgtgtaagc tgctgagggg agccaaagca ctgaccgaca tcgtgcctct gacagaagaa     2400

gccgagctgg aactggccga gaacagagag atcctgaaag aacccgtgca cggagtgtac     2460

tacgacccct ccaaggacct gattgccgag atccagaaac agggacacga ccagtggacc     2520

taccagatct atcaggaacc tttcaagaac ctgaaaacag gcaagtacgc caagatgcgg     2580

acagcccaca ccaacgacgt gaagcagctg accgaagccg tgcagaaaat cgccatggaa     2640

agcatcgtga tctggggaaa gacacccaag ttcaggctgc ccatccagaa agagacatgg     2700

gaaacctggt ggaccgacta ctggcaggcc acctggattc ccgagtggga gttcgtgaac     2760

accccacccc tggtgaagct gtggtatcag ctggaaaagg accctatcgc tggcgtggag     2820

acattctacg tggctggagc tgccaacaga gagacaaagc tgggcaaggc tggctacgtg     2880

accgacagag gcagacagaa aatcgtgagc ctgaccgaaa ccaccaacca gaaaacagcc     2940

ctgcaggcca tctatctggc actgcaggac agcggaagcg aggtgaacat cgtgacagcc     3000

agccagtatg ccctgggcat catccaggcc cagcctgaca agagcgagag cgagctggtg     3060

aaccagatca tcgagcagct gatcaagaaa gaacgggtgt acctgagctg ggtgccagcc     3120

cacaagggca tcggagggaa cgagcaggtg gacaagctgg tgtccagcgg aatccggaag     3180

gtgctgttcc tggacggcat cgataaagcc caggaagagc acgagaagta ccacagcaat     3240

tggagagcca tggccagcga cttcaacctg cctcccgtgg tggccaaaga aatcgtggcc     3300

agctgcgacc agtgccagct gaaaggcgag gccatgcacg gacaggtgga ctgctcccct     3360

ggcatctggc agctggcatg cacccacctg gaaggcaaga tcattctggt ggccgtgcac     3420

gtggccagcg gatacatcga agccgaagtg atccctgccg agacagggca ggaaacagcc     3480

tacttcatcc tgaagctggc tggcagatgg cctgtgaagg tgatccacac agccaacggc     3540

agcaacttca cctctgctgc cgtgaaggct gcctgttggt gggctggcat tcagcaggaa     3600

tttggcatcc cctacaatcc ccagtctcag ggagtggtgg ccagcatgaa caaagagctg     3660

aagaagatca tcggacaggt cagggatcag gccgagcacc tgaaaactgc cgtccagatg     3720

gccgtgttca tccacaactt caagcggaag ggagggatcg gagggtactc tgctggcgag     3780

cggatcatcg acatcattgc caccgatatc cagaccaaag agctgcagaa acagatcatc     3840

aagatccaga acttcagggt gtactacagg gacagcaggg accccatctg gaagggacct     3900

gccaagctgc tgtggaaagg cgaaggagcc gtcgtcatcc aggacaacag cgacatcaag     3960

gtggtgccca gacggaaggt gaaaatcatc aaggactacg gcaaacagat ggctggagcc     4020

gactgtgtcg ctggcaggca ggacgaggac                                      4050


<210>  8
<211>  4023
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mos2.Gag-Pol DNA

<400>  8
atgggagcca gagccagcat cctgcgagga gggaagctgg acaagtggga gaagatcagg       60

ctgaggcctg gagggaagaa acactacatg ctgaagcacc tggtctgggc cagcagagag      120

ctggaacggt ttgccctcaa tcctggcctg ctggaaacca gcgagggctg caagcagatc      180

atcaagcagc tgcagcctgc cctgcagaca ggcaccgagg aactgcggag cctgttcaac      240

accgtggcca ccctgtactg cgtgcatgcc gagatcgaag tgagggacac caaagaagcc      300

ctggacaaga tcgaggaaga gcagaacaag agccagcaga aaacccagca ggccaaagaa      360

gccgacggca aggtctccca gaactacccc atcgtgcaga acctgcaggg acagatggtg      420

caccagccca tcagccctcg gacactgaat gcctgggtga aggtgatcga ggaaaaggcc      480

ttcagccctg aggtgatccc catgttcaca gccctgagcg agggagccac accccaggac      540

ctgaacacca tgctgaacac cgtgggaggg caccaggctg ccatgcagat gctgaaggac      600

accatcaacg aggaagctgc cgagtgggac aggctgcacc ctgtgcacgc tggacctgtg      660

gctcctggcc agatgagaga gcccagaggc agcgatattg ctggcaccac ctccaatctg      720

caggaacaga tcgcctggat gaccagcaac cctcccatcc ctgtgggaga catctacaag      780

cggtggatca tcctgggact gaacaagatc gtgcggatgt acagccctac ctccatcctg      840

gacatcaagc agggacccaa agagcctttc agggactacg tggaccggtt cttcaagacc      900

ctgagagccg agcaggccac ccaggacgtg aagaactgga tgaccgacac cctgctggtg      960

cagaacgcca accctgactg caagaccatc ctgagagccc tgggacctgg agccaccctg     1020

gaagagatga tgacagcctg ccagggagtg ggaggaccct ctcacaaggc tagggtgctg     1080

gccgaggcca tgagccagac caacagcacc atcctgatgc agcggagcaa cttcaagggc     1140

agcaagcgga tcgtgaagtg cttcaactgt ggcaaagagg gacacattgc cagaaactgt     1200

agggcaccca ggaagaaagg ctgctggaag tgcggaaaag aaggccacca gatgaaggac     1260

tgcaccgaga ggcaggccaa cttcctgggc aagatctggc ctagccacaa gggcagacct     1320

ggcaacttcc tgcagagcag acccgagccc accgctcctc cagccgagag cttccggttc     1380

gaggaaacca cccctgctcc caagcaggaa cctaaggaca gagagcctct gaccagcctg     1440

agaagcctgt tcggcagcga ccctctgagc cagatggctc ccatctcccc tatcgagaca     1500

gtgcctgtga agctgaagcc tggcatggac ggacccaagg tgaaacagtg gcctctgacc     1560

gaggaaaaga tcaaagccct ggtggagatc tgtaccgaga tggaaaaaga gggcaagatc     1620

agcaagatcg gacccgagaa cccctacaac acccctatct tcgccatcaa gaagaaagac     1680

agcaccaagt ggaggaaact ggtggacttc agagagctga acaagcggac ccaggacttc     1740

tgggaggtgc agctgggcat ccctcaccct gctggcctga agaaaaagaa aagcgtgacc     1800

gtgctggccg tgggagatgc ctacttcagc gtgcctctgg acgaggactt cagaaagtac     1860

acagccttca ccatccccag catcaacaac gagacacctg gcatcagata ccagtacaac     1920

gtgctgcctc agggatggaa gggctctcct gcaatcttcc agagcagcat gaccaagatc     1980

ctggaaccct tccggaagca gaaccctgac atcgtgatct accagtacat ggcagccctg     2040

tacgtcggca gcgacctgga aatcggacag caccggacca agatcgaaga actcaggcag     2100

cacctgctgc ggtggggatt caccacccct gacaagaagc accagaaaga gcctcccttc     2160

ctgtggatgg gctacgagct gcacccagac aagtggaccg tgcagcccat cgtgctgcct     2220

gagaaggact cctggaccgt gaacgacatc cagaaactgg tcggcaagct gaactgggcc     2280

agccagatct acgctggcat caaagtgaag cagctgtgta agctcctgag aggcaccaaa     2340

gccctgaccg aggtggtgcc actgacagag gaagccgagc tggaactggc cgagaacaga     2400

gagatcctga aagaacccgt gcacggagtg tactacgacc ccagcaagga cctgattgcc     2460

gagatccaga agcagggaca gggacagtgg acctaccaga tctaccagga acccttcaag     2520

aacctgaaaa caggcaagta cgccaggatg aggggagccc acaccaacga cgtcaaacag     2580

ctgaccgaag ccgtgcagaa gatcgccacc gagagcatcg tgatttgggg aaagacaccc     2640

aagttcaagc tgcccatcca gaaagagaca tgggaggcct ggtggaccga gtactggcag     2700

gccacctgga ttcccgagtg ggagttcgtg aacaccccac ccctggtgaa gctgtggtat     2760

cagctggaaa aagaacccat cgtgggagcc gagacattct acgtggctgg agctgccaac     2820

agagagacaa agctgggcaa ggctggctac gtgaccgaca gaggcaggca gaaagtggtg     2880

tccctgaccg ataccaccaa ccagaaaaca gccctgcagg ccatccacct ggctctgcag     2940

gactctggcc tggaagtgaa catcgtgaca gccagccagt atgccctggg catcattcag     3000

gcacagcctg acaagagcga gagcgagctg gtgtctcaga tcattgagca gctgatcaag     3060

aaagaaaagg tgtacctggc ctgggtgcca gcccacaagg ggatcggagg gaacgagcag     3120

gtggacaagc tggtgtccag gggcatccgg aaggtgctgt ttctggacgg catcgacaaa     3180

gcccaggaag agcacgagaa gtaccacagc aattggagag ccatggccag cgagttcaac     3240

ctgcctccca tcgtggccaa agaaatcgtg gcctcttgcg acaagtgcca gctgaaaggc     3300

gaggccattc acggacaggt ggactgcagc ccaggcatct ggcagctggc ctgcacccac     3360

ctggaaggca aggtgatcct ggtggccgtg cacgtggcct ctggatacat cgaagccgaa     3420

gtgatccctg ccgagacagg ccaggaaaca gcctacttcc tgctgaagct ggctggcagg     3480

tggcctgtga aaaccatcca cacagccaac ggcagcaact tcacctctgc caccgtgaag     3540

gctgcctgtt ggtgggctgg cattaagcag gaatttggca tcccctacaa ccctcagtct     3600

cagggagtgg tggcctccat caacaaagag ctgaagaaga tcatcggaca ggtcagggat     3660

caggccgagc atctgaaaac agccgtccag atggccgtgt tcatccacaa cttcaagcgg     3720

aagggaggga tcggagagta ctctgctggc gagaggatcg tggacattat cgccagcgat     3780

atccagacca aagaactgca gaagcagatc acaaagatcc agaacttcag ggtgtactac     3840

agggacagca gagatcccct gtggaaggga cctgccaagc tgctgtggaa aggcgaagga     3900

gccgtcgtca tccaggacaa cagcgacatc aaggtggtgc ccagacggaa ggccaagatc     3960

atcagagact acggcaaaca gatggctggc gacgactgcg tcgcctctag gcaggacgag     4020

gac                                                                   4023


<210>  9
<211>  679
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clade C gp140 protein

<400>  9

Ala Glu Asn Leu Trp Val Gly Asn Met Trp Val Thr Val Tyr Tyr Gly 
1               5                   10                  15      


Val Pro Val Trp Thr Asp Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp 
            20                  25                  30          


Thr Lys Ala Tyr Asp Arg Glu Val His Asn Val Trp Ala Thr His Ala 
        35                  40                  45              


Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Ile Val Leu Glu Asn Val 
    50                  55                  60                  


Thr Glu Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln Met His 
65                  70                  75                  80  


Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys 
                85                  90                  95      


Leu Thr Pro Leu Cys Val Thr Leu His Cys Thr Asn Ala Thr Phe Lys 
            100                 105                 110         


Asn Asn Val Thr Asn Asp Met Asn Lys Glu Ile Arg Asn Cys Ser Phe 
        115                 120                 125             


Asn Thr Thr Thr Glu Ile Arg Asp Lys Lys Gln Gln Gly Tyr Ala Leu 
    130                 135                 140                 


Phe Tyr Arg Pro Asp Ile Val Leu Leu Lys Glu Asn Arg Asn Asn Ser 
145                 150                 155                 160 


Asn Asn Ser Glu Tyr Ile Leu Ile Asn Cys Asn Ala Ser Thr Ile Thr 
                165                 170                 175     


Gln Ala Cys Pro Lys Val Asn Phe Asp Pro Ile Pro Ile His Tyr Cys 
            180                 185                 190         


Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Ser 
        195                 200                 205             


Gly Lys Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly 
    210                 215                 220                 


Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
225                 230                 235                 240 


Glu Lys Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asp Asn Val Lys 
                245                 250                 255     


Thr Ile Ile Val His Leu Asn Lys Ser Val Glu Ile Val Cys Thr Arg 
            260                 265                 270         


Pro Asn Asn Asn Thr Arg Lys Ser Met Arg Ile Gly Pro Gly Gln Thr 
        275                 280                 285             


Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala Tyr Cys 
    290                 295                 300                 


Asn Ile Ser Gly Ser Lys Trp Asn Glu Thr Leu Lys Arg Val Lys Glu 
305                 310                 315                 320 


Lys Leu Gln Glu Asn Tyr Asn Asn Asn Lys Thr Ile Lys Phe Ala Pro 
                325                 330                 335     


Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Arg 
            340                 345                 350         


Gly Glu Phe Phe Tyr Cys Asn Thr Thr Arg Leu Phe Asn Asn Asn Ala 
        355                 360                 365             


Thr Glu Asp Glu Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile 
    370                 375                 380                 


Asn Met Trp Gln Gly Val Gly Arg Ala Met Tyr Ala Pro Pro Ile Ala 
385                 390                 395                 400 


Gly Asn Ile Thr Cys Lys Ser Asn Ile Thr Gly Leu Leu Leu Val Arg 
                405                 410                 415     


Asp Gly Gly Glu Asp Asn Lys Thr Glu Glu Ile Phe Arg Pro Gly Gly 
            420                 425                 430         


Gly Asn Met Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val 
        435                 440                 445             


Ile Glu Leu Lys Pro Leu Gly Ile Ala Pro Thr Gly Ala Lys Glu Arg 
    450                 455                 460                 


Val Val Glu Arg Glu Glu Arg Ala Val Gly Ile Gly Ala Val Phe Leu 
465                 470                 475                 480 


Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Leu Thr 
                485                 490                 495     


Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Ser Ile Val Gln Gln Gln 
            500                 505                 510         


Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu 
        515                 520                 525             


Thr Val Trp Gly Ile Lys Gln Leu Gln Thr Arg Val Leu Ala Ile Glu 
    530                 535                 540                 


Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly 
545                 550                 555                 560 


Lys Leu Ile Cys Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn 
                565                 570                 575     


Lys Ser Gln Thr Asp Ile Trp Asn Asn Met Thr Trp Met Glu Trp Asp 
            580                 585                 590         


Arg Glu Ile Ser Asn Tyr Thr Asp Thr Ile Tyr Arg Leu Leu Glu Asp 
        595                 600                 605             


Ser Gln Thr Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu Ala Leu Asp 
    610                 615                 620                 


Ser Trp Lys Asn Leu Trp Ser Trp Phe Asp Ile Ser Asn Trp Leu Trp 
625                 630                 635                 640 


Tyr Ile Lys Ser Arg Ile Glu Gly Arg Gly Ser Gly Gly Tyr Ile Pro 
                645                 650                 655     


Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp 
            660                 665                 670         


Val Leu Leu Ser Thr Phe Leu 
        675                 


<210>  10
<211>  695
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mosaic gp140 protein

<400>  10

Ala Gly Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys 
1               5                   10                  15      


Glu Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp 
            20                  25                  30          


Thr Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp 
        35                  40                  45              


Pro Asn Pro Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn 
    50                  55                  60                  


Met Trp Lys Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser 
65                  70                  75                  80  


Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys 
                85                  90                  95      


Val Thr Leu Asn Cys Thr Asp Asp Val Arg Asn Val Thr Asn Asn Ala 
            100                 105                 110         


Thr Asn Thr Asn Ser Ser Trp Gly Glu Pro Met Glu Lys Gly Glu Ile 
        115                 120                 125             


Lys Asn Cys Ser Phe Asn Ile Thr Thr Ser Ile Arg Asn Lys Val Gln 
    130                 135                 140                 


Lys Gln Tyr Ala Leu Phe Tyr Lys Leu Asp Val Val Pro Ile Asp Asn 
145                 150                 155                 160 


Asp Ser Asn Asn Thr Asn Tyr Arg Leu Ile Ser Cys Asn Thr Ser Val 
                165                 170                 175     


Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His 
            180                 185                 190         


Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys 
        195                 200                 205             


Phe Asn Gly Thr Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr 
    210                 215                 220                 


His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser 
225                 230                 235                 240 


Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn 
                245                 250                 255     


Ala Lys Thr Ile Met Val Gln Leu Asn Val Ser Val Glu Ile Asn Cys 
            260                 265                 270         


Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile His Ile Gly Pro Gly 
        275                 280                 285             


Arg Ala Phe Tyr Thr Ala Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala 
    290                 295                 300                 


His Cys Asn Ile Ser Arg Ala Asn Trp Asn Asn Thr Leu Arg Gln Ile 
305                 310                 315                 320 


Val Glu Lys Leu Gly Lys Gln Phe Gly Asn Asn Lys Thr Ile Val Phe 
                325                 330                 335     


Asn His Ser Ser Gly Gly Asp Pro Glu Ile Val Met His Ser Phe Asn 
            340                 345                 350         


Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser Thr Lys Leu Phe Asn Ser 
        355                 360                 365             


Thr Trp Thr Trp Asn Asn Ser Thr Trp Asn Asn Thr Lys Arg Ser Asn 
    370                 375                 380                 


Asp Thr Glu Glu His Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile 
385                 390                 395                 400 


Asn Met Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg 
                405                 410                 415     


Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg 
            420                 425                 430         


Asp Gly Gly Asn Asp Thr Ser Gly Thr Glu Ile Phe Arg Pro Gly Gly 
        435                 440                 445             


Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val 
    450                 455                 460                 


Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Glu Arg 
465                 470                 475                 480 


Val Val Gln Arg Glu Glu Arg Ala Val Gly Ile Gly Ala Val Phe Leu 
                485                 490                 495     


Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met Thr 
            500                 505                 510         


Leu Thr Val Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln Gln 
        515                 520                 525             


Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu 
    530                 535                 540                 


Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu 
545                 550                 555                 560 


Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly 
                565                 570                 575     


Lys Leu Ile Cys Thr Thr Thr Val Pro Trp Asn Ala Ser Trp Ser Asn 
            580                 585                 590         


Lys Ser Leu Asp Lys Ile Trp Asn Asn Met Thr Trp Met Glu Trp Glu 
        595                 600                 605             


Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile Tyr Thr Leu Ile Glu Glu 
    610                 615                 620                 


Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp 
625                 630                 635                 640 


Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu Trp 
                645                 650                 655     


Tyr Ile Lys Ser Arg Ile Glu Gly Arg Gly Ser Gly Gly Tyr Ile Pro 
            660                 665                 670         


Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp 
        675                 680                 685             


Val Leu Leu Ser Thr Phe Leu 
    690                 695 


<210>  11
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary leader sequence for gp140 stabilized trimeric protein 
       production

<400>  11

Met Arg Val Arg Gly Ile Gln Arg Asn Cys Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Met Leu Met Ile Cys Ser Ala 
            20                  25                  


<210>  12
<211>  711
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mos2S.Env protein sequence

<400>  12

Met Arg Val Arg Gly Met Leu Arg Asn Trp Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Ser Ser Leu Gly Phe Trp Met Leu Met Ile Tyr Ser Val Met Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Val Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Ala Ser Leu Glu Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Arg Asn Val Arg Asn Val Ser Ser Asn Gly Thr Tyr Asn Ile 
    130                 135                 140                 


Ile His Asn Glu Thr Tyr Lys Glu Met Lys Asn Cys Ser Phe Asn Ala 
145                 150                 155                 160 


Thr Thr Val Val Glu Asp Arg Lys Gln Lys Val His Ala Leu Phe Tyr 
                165                 170                 175     


Arg Leu Asp Ile Val Pro Leu Asp Glu Asn Asn Ser Ser Glu Lys Ser 
            180                 185                 190         


Ser Glu Asn Ser Ser Glu Tyr Tyr Arg Leu Ile Asn Cys Asn Thr Ser 
        195                 200                 205             


Ala Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile 
    210                 215                 220                 


His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys 
225                 230                 235                 240 


Thr Phe Asn Gly Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys 
                245                 250                 255     


Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly 
            260                 265                 270         


Ser Leu Ala Glu Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn 
        275                 280                 285             


Asn Ala Lys Thr Ile Ile Val His Leu Asn Glu Thr Val Asn Ile Thr 
    290                 295                 300                 


Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro 
305                 310                 315                 320 


Gly Gln Thr Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln 
                325                 330                 335     


Ala His Cys Asn Leu Ser Arg Asp Gly Trp Asn Lys Thr Leu Gln Gly 
            340                 345                 350         


Val Lys Lys Lys Leu Ala Glu His Phe Pro Asn Lys Thr Ile Lys Phe 
        355                 360                 365             


Ala Pro His Ser Gly Gly Asp Leu Glu Ile Thr Thr His Thr Phe Asn 
    370                 375                 380                 


Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr Ser Asn Leu Phe Asn Glu 
385                 390                 395                 400 


Ser Asn Ile Glu Arg Asn Asp Ser Ile Ile Thr Leu Pro Cys Arg Ile 
                405                 410                 415     


Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg Ala Ile Tyr Ala 
            420                 425                 430         


Pro Pro Ile Ala Gly Asn Ile Thr Cys Arg Ser Asn Ile Thr Gly Leu 
        435                 440                 445             


Leu Leu Thr Arg Asp Gly Gly Ser Asn Asn Gly Val Pro Asn Asp Thr 
    450                 455                 460                 


Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asn Asn Trp Arg Ser 
465                 470                 475                 480 


Glu Leu Tyr Lys Tyr Lys Val Val Glu Val Lys Pro Leu Gly Val Ala 
                485                 490                 495     


Pro Thr Glu Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val 
            500                 505                 510         


Gly Ile Gly Ala Val Phe Leu Gly Ile Leu Gly Ala Ala Gly Ser Thr 
        515                 520                 525             


Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu 
    530                 535                 540                 


Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala 
545                 550                 555                 560 


Gln Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln 
                565                 570                 575     


Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Gln Asp Gln Gln Leu Leu 
            580                 585                 590         


Gly Leu Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val Pro 
        595                 600                 605             


Trp Asn Thr Ser Trp Ser Asn Lys Ser Gln Thr Asp Ile Trp Asp Asn 
    610                 615                 620                 


Met Thr Trp Met Gln Trp Asp Lys Glu Ile Gly Asn Tyr Thr Gly Glu 
625                 630                 635                 640 


Ile Tyr Arg Leu Leu Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu 
                645                 650                 655     


Lys Asp Leu Leu Ala Leu Asp Ser Trp Asn Asn Leu Trp Asn Trp Phe 
            660                 665                 670         


Ser Ile Ser Lys Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val 
        675                 680                 685             


Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser Ile Val 
    690                 695                 700                 


Asn Arg Val Arg Gln Gly Tyr 
705                 710     


<210>  13
<211>  2133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mos2S.Env DNA

<400>  13
atgagagtgc ggggcatgct gagaaactgg cagcagtggt ggatctggtc cagcctgggc       60

ttctggatgc tgatgatcta cagcgtgatg ggcaacctgt gggtcaccgt gtactacggc      120

gtgcccgtgt ggaaggacgc caagaccacc ctgttttgcg cctccgatgc caaggcctac      180

gagaaagagg tgcacaacgt ctgggccacc cacgcctgtg tgcccaccga ccccaatccc      240

caggaaatcg tcctgggcaa cgtgaccgag aacttcaaca tgtggaagaa cgacatggtc      300

gatcagatgc acgaggacat catctccctg tgggacgcct ccctggaacc ctgcgtgaag      360

ctgacccctc tgtgcgtgac cctgaactgc cggaacgtgc gcaacgtgtc cagcaacggc      420

acctacaaca tcatccacaa cgagacatac aaagagatga agaactgcag cttcaacgct      480

accaccgtgg tcgaggaccg gaagcagaag gtgcacgccc tgttctaccg gctggacatc      540

gtgcccctgg acgagaacaa cagcagcgag aagtcctccg agaacagctc cgagtactac      600

agactgatca actgcaacac cagcgccatc acccaggcct gccccaaggt gtccttcgac      660

cctatcccca tccactactg cgcccctgcc ggctacgcca tcctgaagtg caacaacaag      720

accttcaatg gcaccggccc ctgcaacaat gtgtccaccg tgcagtgcac ccacggcatc      780

aagcccgtgg tgtctaccca gctgctgctg aacggcagcc tggccgagga agagatcatt      840

atcagaagcg agaacctgac caacaacgcc aaaaccatca tcgtccacct gaacgaaacc      900

gtgaacatca cctgtacccg gcctaacaac aacacccgga agtccatccg gatcggccct      960

ggccagacct tttacgccac cggcgatatt atcggcgaca tccggcaggc ccactgcaat     1020

ctgagccggg acggctggaa caagacactg cagggcgtca agaagaagct ggccgaacac     1080

ttccctaaca agactatcaa gttcgcccct cactctggcg gcgacctgga aatcaccacc     1140

cacaccttca actgtcgggg cgagttcttc tactgcaata cctccaacct gttcaacgag     1200

agcaacatcg agcggaacga cagcatcatc acactgcctt gccggatcaa gcagattatc     1260

aatatgtggc aggaagtggg cagagccatc tacgcccctc caatcgccgg caacatcaca     1320

tgccggtcca atatcaccgg cctgctgctc accagagatg gcggctccaa caatggcgtg     1380

ccaaacgaca ccgagacatt cagacccggc ggaggcgaca tgcggaacaa ttggcggagc     1440

gagctgtaca agtacaaggt ggtggaagtg aagcccctgg gcgtggcccc taccgaggcc     1500

aagagaagag tggtcgaacg cgagaagcgg gccgtgggaa tcggagccgt gtttctggga     1560

atcctgggag ccgctggctc taccatgggc gctgcctcta tcaccctgac agtgcaggcc     1620

agacagctgc tcagcggcat cgtgcagcag cagagcaacc tgctgagagc cattgaggcc     1680

cagcagcaca tgctgcagct gaccgtgtgg ggcattaagc agctccagac acgggtgctg     1740

gccatcgaga gatacctgca ggatcagcag ctcctgggcc tgtggggctg tagcggcaag     1800

ctgatctgta ccaccgccgt gccctggaat acctcttgga gcaacaagag ccagaccgac     1860

atctgggaca acatgacctg gatgcagtgg gacaaagaaa tcggcaacta taccggcgag     1920

atctatagac tgctggaaga gtcccagaac cagcaggaaa agaacgagaa ggacctgctg     1980

gccctggatt cttggaacaa tctgtggaac tggttcagca tctccaagtg gctgtggtac     2040

atcaagatct tcatcatgat cgtgggcggc ctgatcggcc tgcggatcat ctttgccgtg     2100

ctgagcatcg tgaaccgcgt gcggcagggc tac                                  2133


