                         SEQUENCE LISTING

<110>  Lentigen Technology, Inc.
 
<120>  COMPOSITIONS AND METHODS FOR TREATING CANCER WITH ANTI-CD19 
       IMMUNOTHERAPY

<130>  42449-0016WO1

<150>  US 62/559,297
<151>  2017-09-15

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19-reactive ScFv1 binding domain (LTG2050)

<400>  1
gaggtccagc tggtacagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatcggat      300

cggggaatta ccgccacgga cgcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttcaggag gtggcgggtc tggtggaggc ggtagcggtg gtggcggatc ccagtctgtg      420

ctgactcagc caccctcggt gtcagtggcc ccagggcaga cggccaagat tacctgtggg      480

ggaagtgaca ttggaaataa aaatgtccac tggtaccagc agaagccagg ccaggcccct      540

gtcctggtcg tctatgatga ttacgaccgg ccctcaggga tccctgagcg attctctggc      600

tccaactctg gggacgcggc caccctgacg atcagcacgg tcgaagtcgg ggatgaggcc      660

gactatttct gtcaggtgtg ggacagtagt ggtgatcctt attgggtgtt cggcggaggg      720

acccagctca ccgttttagg t                                                741


<210>  2
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19-reactive ScFv1 binding domain (LTG2050)

<400>  2

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro 
    130                 135                 140                 


Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Lys Ile Thr Cys Gly 
145                 150                 155                 160 


Gly Ser Asp Ile Gly Asn Lys Asn Val His Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Tyr Asp Arg Pro Ser 
            180                 185                 190         


Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asp Ala Ala Thr 
        195                 200                 205             


Leu Thr Ile Ser Thr Val Glu Val Gly Asp Glu Ala Asp Tyr Phe Cys 
    210                 215                 220                 


Gln Val Trp Asp Ser Ser Gly Asp Pro Tyr Trp Val Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Gln Leu Thr Val Leu Gly 
                245         


<210>  3
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19-reactive ScFv2 binding domain (LTG2065)

<400>  3
gaggtccagc tggtacagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatta atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatcggat      300

cggggaatta ccgccacgga cgcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttcaggcg gaggaggctc cgggggagga ggttccgggg gcgggggttc ccagtctgtg      420

ctgactcagc caccctcggt gtcagtggcc ccagggcgga tggccaagat tacctgtggg      480

ggaagtgaca ttggaaataa aaatgtccac tggtatcagc agaagccagg ccaggcccct      540

gtcctggttg tctatgatga ttacgaccgg ccctcaggga tccctgagcg attctctggc      600

tccaactctg gggacgcggc caccctgacg atcagcacgg tcgaagtcgg ggatgaggcc      660

gactatttct gtcaggtgtg ggacggtagt ggtgatcctt attggatgtt cggcggaggg      720

acccagctca ccgttttagg t                                                741


<210>  4
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19-reactive ScFv2 binding domain (LTG2065)

<400>  4

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro 
    130                 135                 140                 


Pro Ser Val Ser Val Ala Pro Gly Arg Met Ala Lys Ile Thr Cys Gly 
145                 150                 155                 160 


Gly Ser Asp Ile Gly Asn Lys Asn Val His Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Tyr Asp Arg Pro Ser 
            180                 185                 190         


Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asp Ala Ala Thr 
        195                 200                 205             


Leu Thr Ile Ser Thr Val Glu Val Gly Asp Glu Ala Asp Tyr Phe Cys 
    210                 215                 220                 


Gln Val Trp Asp Gly Ser Gly Asp Pro Tyr Trp Met Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Gln Leu Thr Val Leu Gly 
                245         


<210>  5
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19-reactive ScFv3 binding domain (LTG2066)

<400>  5
gaggtccagc tggtacagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttccggata caccttcacc agctactaca tgcactgggt gcgacaggcc      120

cctggacaag ggtttgagtg gatgggatta atcaacccta gtggtagtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcaacctgag atctgaggac acggccgtgt attactgtgc gagatcggat      300

cggggaatta ccgccacgga cgcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttcaggcg gaggaggctc cgggggagga ggttccgggg gcgggggttc ccagtctgtg      420

ctgactcagc caccctcggt gccagtggcc ccagggcaga cggccaagat tatctgtggg      480

ggaagtgaca ttggaaataa aaatgtccac tggtaccagc agaagccagg ccaggcccct      540

gtcctggtcg tctatgatga ctacgaccgg ccctcaggga tccctgagcg attctctggc      600

tccaactctg gggacgcggc caccctgacg atcagcacgg ttgaagtcgg ggatgaggcc      660

gactatttct gtcaggtgtg ggacggtagt ggtgatcctt attgggtgtt cggcggaggg      720

acccagctca ccgtcttagg t                                                741


<210>  6
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19-reactive ScFv3 binding domain (LTG2066)

<400>  6

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Ser Gly Ser Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro 
    130                 135                 140                 


Pro Ser Val Pro Val Ala Pro Gly Gln Thr Ala Lys Ile Ile Cys Gly 
145                 150                 155                 160 


Gly Ser Asp Ile Gly Asn Lys Asn Val His Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Tyr Asp Arg Pro Ser 
            180                 185                 190         


Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asp Ala Ala Thr 
        195                 200                 205             


Leu Thr Ile Ser Thr Val Glu Val Gly Asp Glu Ala Asp Tyr Phe Cys 
    210                 215                 220                 


Gln Val Trp Asp Gly Ser Gly Asp Pro Tyr Trp Val Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Gln Leu Thr Val Leu Gly 
                245         


<210>  7
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19-reactive ScFv4 binding domain (LTG2067)

<400>  7
gaggtccagc tggtacagtc tggagctgag gtgaacaagc ctggtgcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaatg atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatcggat      300

cggggaatta cctccacgga cgcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttcaggcg gaggaggctc cgggggagga ggttccgggg gcgggggttc ccagtctgtg      420

ctgactcagc caccctcggt gtcattggcc ccagggcaga cggccaagat tacctgtggg      480

ggaagtgaca ttggaaataa aaatgtccac tggtaccagc agaagccagg ccaggcccct      540

gtcctagtcg tctatgatga ttacaaccgg ccctcaggga tccctgagcg attctctggc      600

tccaactctg gggactcagc caccctgacg atcagcacgg tcgaagtcgg ggatgaggcc      660

gactatttct gtcaggtgtg ggacggtagt ggtgatcctt attgggtgtt cggcggaggg      720

acccagctca ccgttttagg t                                                741


<210>  8
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19-reactive ScFv4 binding domain (LTG2067)

<400>  8

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Asn Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Arg Gly Ile Thr Ser Thr Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro 
    130                 135                 140                 


Pro Ser Val Ser Leu Ala Pro Gly Gln Thr Ala Lys Ile Thr Cys Gly 
145                 150                 155                 160 


Gly Ser Asp Ile Gly Asn Lys Asn Val His Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Tyr Asn Arg Pro Ser 
            180                 185                 190         


Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asp Ser Ala Thr 
        195                 200                 205             


Leu Thr Ile Ser Thr Val Glu Val Gly Asp Glu Ala Asp Tyr Phe Cys 
    210                 215                 220                 


Gln Val Trp Asp Gly Ser Gly Asp Pro Tyr Trp Val Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Gln Leu Thr Val Leu Gly 
                245         


<210>  9
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19-reactive ScFv5 binding domain (LTG2068)

<400>  9
gaggtccagc tggtacagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg catctggata caccttcacc ggctactata tgcactgggt gcggcaggcc      120

cctggacaag ggcttgagtg gataggatta atcaacccta gtggtggtag cacaagctac      180

gaacagaagt tccagggcag agtcgccatg accagggaca cgtcaacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatcggat      300

cggggaatta ccgccacgga cgcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttcaggcg gaggaggctc cgggggagga ggttccgggg gcgggggttc ccagtctgtg      420

ctgactcagc caccctcggt gtcagtggcc ccagggcaga cggccaagat tacctgtggg      480

ggaagtgaca ttggagataa aaatgtccac tggtaccagc agaagccagg ccaggcccct      540

gtcctggtcg tctatgatga ttacgaccgg ccctcaggga tccctgagcg attctctggc      600

tccaactctg gggacgcggc caccctgacg atcagcacgg tcgaagtcgg ggatgaggcc      660

gactatttct gtcaggtgtg ggacggtatt ggtgatccct attgggtgtt cggcggaggg      720

acccagctca ccgttttagg t                                                741


<210>  10
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19-reactive ScFv5 binding domain (LTG2068)

<400>  10

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Glu Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ala Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro 
    130                 135                 140                 


Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Lys Ile Thr Cys Gly 
145                 150                 155                 160 


Gly Ser Asp Ile Gly Asp Lys Asn Val His Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Tyr Asp Arg Pro Ser 
            180                 185                 190         


Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asp Ala Ala Thr 
        195                 200                 205             


Leu Thr Ile Ser Thr Val Glu Val Gly Asp Glu Ala Asp Tyr Phe Cys 
    210                 215                 220                 


Gln Val Trp Asp Gly Ile Gly Asp Pro Tyr Trp Val Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Gln Leu Thr Val Leu Gly 
                245         


<210>  11
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19-reactive ScFv6 binding domain (LTG2069)

<400>  11
gaggtccagc tagtacagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaatg atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatcggat      300

cggggaatta ccgccacgga cgcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttcaggcg gaggaggctc cgggggagga ggttccgggg gcgggggttc ccagtctgtg      420

ctgactcagc caccctcggt gtcagtggcc ccagggcaga cggccaagat tacctgtggg      480

ggaagtgaca ttggaaataa aaatgcccac tggtaccagc agaagccagg ccaggcccct      540

gtcctggtcg tctatgatga ttacgaccgg ccctcaggga tctctgagcg attctctggc      600

tccaactctg gggacgcggc caccctgacg atcagcacgg tcgaagtcgg ggatgaggcc      660

gactatttct gtcaggtgtg ggacggtagt ggtgatcctt tttgggtgtt cggcggaggg      720

acccagctca ccgttttagg t                                                741


<210>  12
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19-reactive ScFv6 binding domain (LTG2069)

<400>  12

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro 
    130                 135                 140                 


Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Lys Ile Thr Cys Gly 
145                 150                 155                 160 


Gly Ser Asp Ile Gly Asn Lys Asn Ala His Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Tyr Asp Arg Pro Ser 
            180                 185                 190         


Gly Ile Ser Glu Arg Phe Ser Gly Ser Asn Ser Gly Asp Ala Ala Thr 
        195                 200                 205             


Leu Thr Ile Ser Thr Val Glu Val Gly Asp Glu Ala Asp Tyr Phe Cys 
    210                 215                 220                 


Gln Val Trp Asp Gly Ser Gly Asp Pro Phe Trp Val Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Gln Leu Thr Val Leu Gly 
                245         


<210>  13
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19-reactive ScFv7 binding domain (LTG2070)

<400>  13
gaggtccagc tggtacagtc tggagctgag gtgaagaggc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacgag ggcttgagtg gatgggatta atcaacccta gtggtggtag cacaagctac      180

gcacaggagt tccagggcag agtcaccatg accagggaca tgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatcggat      300

cggggaatta gcgccacgga cgcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttcaggcg gaggaggctc cgggggagga ggttccgggg gcgggggttc ccagtctgtg      420

ctgactcagc caccctcggt gtcagtggcc ccagggcaga tggccaagat tacctgtggg      480

ggaagtgaca ttggaaataa aaatgtccac tggtaccagc agaagccagg ccaggcccct      540

gtcctggtcg tctatgatga ttacaaccgg ccctcaggga tccctgagcg attctctggc      600

tccaactctg gggacgcggc caccctgacg atcagcacgg tcgaagtcgg ggatgaggcc      660

gactatttct gtcaggtatg ggacggtagt ggtgatcctt attgggtgtt cggcggaggg      720

acccagctca ccgatttagg t                                                741


<210>  14
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19-reactive ScFv7 binding domain (LTG2070)

<400>  14

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Glu Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Met Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Arg Gly Ile Ser Ala Thr Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro 
    130                 135                 140                 


Pro Ser Val Ser Val Ala Pro Gly Gln Met Ala Lys Ile Thr Cys Gly 
145                 150                 155                 160 


Gly Ser Asp Ile Gly Asn Lys Asn Val His Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Tyr Asn Arg Pro Ser 
            180                 185                 190         


Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asp Ala Ala Thr 
        195                 200                 205             


Leu Thr Ile Ser Thr Val Glu Val Gly Asp Glu Ala Asp Tyr Phe Cys 
    210                 215                 220                 


Gln Val Trp Asp Gly Ser Gly Asp Pro Tyr Trp Val Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Gln Leu Thr Asp Leu Gly 
                245         


<210>  15
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19-reactive ScFv8 binding domain (LTG2071)

<400>  15
gaggtccagc tggtacagtc tggagctgag gtgaagaggc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgtgtg gatgggatta atcaacccta gtggtggcag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatcggat      300

cggggaatta ccgccacgga cgcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttcaggcg gaggaggctc cgggggagga ggttccgggg gcgggggttc ccagtctgtg      420

ctgactcagc caccctcggt ctcagtggcc ccagggcaga cggccaagac tacctgtggg      480

ggaagtgaca ttggaaataa aaatgtccac tggtaccagc agaagccagg ccaggcccct      540

gtcctggtcg tctatgatga ttacgaccgg ccctcaggga tccctgagcg attctctggc      600

tccaactctg gggacgcggc caccctgacg atcagcacgg tcgaagtcgg ggatgaggcc      660

gactatgtct gtcaggtgtg ggacggtagt ggtgatcctt attgggtgtt cggcggaggg      720

acccagctca ccgttttagg t                                                741


<210>  16
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19-reactive ScFv8 binding domain (LTG2071)

<400>  16

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Val Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro 
    130                 135                 140                 


Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Lys Thr Thr Cys Gly 
145                 150                 155                 160 


Gly Ser Asp Ile Gly Asn Lys Asn Val His Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Tyr Asp Arg Pro Ser 
            180                 185                 190         


Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asp Ala Ala Thr 
        195                 200                 205             


Leu Thr Ile Ser Thr Val Glu Val Gly Asp Glu Ala Asp Tyr Val Cys 
    210                 215                 220                 


Gln Val Trp Asp Gly Ser Gly Asp Pro Tyr Trp Val Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Gln Leu Thr Val Leu Gly 
                245         


<210>  17
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader/signal peptide sequence (LP)

<400>  17
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccg                                                                  66


<210>  18
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader/signal peptide sequence (LP)

<400>  18

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  19
<211>  1485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG2050_(LP-M19217-CD8 TM-41BB-CD3 zeta)

<400>  19
atgcttctcc tggtcacctc cctgctcctc tgcgaactgc ctcaccctgc cttccttctg       60

attcctgagg tccagctggt acagtctgga gctgaggtga agaagcctgg ggcctcagtg      120

aaggtctcct gcaaggcttc tggatacacc ttcaccagct actatatgca ctgggtgcga      180

caggcccctg gacaagggct tgagtggatg ggaataatca accctagtgg tggtagcaca      240

agctacgcac agaagttcca gggcagagtc accatgacca gggacacgtc cacgagcaca      300

gtctacatgg agctgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcgaga      360

tcggatcggg gaattaccgc cacggacgct tttgatatct ggggccaagg gacaatggtc      420

accgtctctt caggaggtgg cgggtctggt ggaggcggta gcggtggtgg cggatcccag      480

tctgtgctga ctcagccacc ctcggtgtca gtggccccag ggcagacggc caagattacc      540

tgtgggggaa gtgacattgg aaataaaaat gtccactggt accagcagaa gccaggccag      600

gcccctgtcc tggtcgtcta tgatgattac gaccggccct cagggatccc tgagcgattc      660

tctggctcca actctgggga cgcggccacc ctgacgatca gcacggtcga agtcggggat      720

gaggccgact atttctgtca ggtgtgggac agtagtggtg atccttattg ggtgttcggc      780

ggagggaccc agctcaccgt tttaggtgcg gccgcaacta ccacccctgc ccctcggccg      840

ccgactccgg ccccaaccat cgcaagccaa cccctctcct tgcgccccga agcttgccgc      900

ccggccgcgg gtggagccgt gcatacccgg gggctggact ttgcctgcga tatctacatt      960

tgggccccgc tggccggcac ttgcggcgtg ctcctgctgt cgctggtcat caccctttac     1020

tgcaagaggg gccggaagaa gctgctttac atcttcaagc agccgttcat gcggcccgtg     1080

cagacgactc aggaagagga cggatgctcg tgcagattcc ctgaggagga agagggggga     1140

tgcgaactgc gcgtcaagtt ctcacggtcc gccgacgccc ccgcatatca acagggccag     1200

aatcagctct acaacgagct gaacctggga aggagagagg agtacgacgt gctggacaag     1260

cgacgcggac gcgacccgga gatggggggg aaaccacggc ggaaaaaccc tcaggaagga     1320

ctgtacaacg aactccagaa agacaagatg gcggaagcct actcagaaat cgggatgaag     1380

ggagagcgga ggaggggaaa gggtcacgac gggctgtacc agggactgag caccgccact     1440

aaggatacct acgatgcctt gcatatgcaa gcactcccac cccgg                     1485


<210>  20
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG2050_(LP-M19217-CD8 TM-41BB-CD3zeta)

<400>  20

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
145                 150                 155                 160 


Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr 
                165                 170                 175     


Ala Lys Ile Thr Cys Gly Gly Ser Asp Ile Gly Asn Lys Asn Val His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp 
        195                 200                 205             


Asp Tyr Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn 
    210                 215                 220                 


Ser Gly Asp Ala Ala Thr Leu Thr Ile Ser Thr Val Glu Val Gly Asp 
225                 230                 235                 240 


Glu Ala Asp Tyr Phe Cys Gln Val Trp Asp Ser Ser Gly Asp Pro Tyr 
                245                 250                 255     


Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  21
<211>  1485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG2065 (LP-M19217-1-CD8 TM-41BB-CD3 zeta)

<400>  21
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggagg tccagctggt acagtctgga gctgaggtga agaagcctgg ggcctcagtg      120

aaggtctcct gcaaggcttc tggatacacc ttcaccagct actatatgca ctgggtgcga      180

caggcccctg gacaagggct tgagtggatg ggattaatca accctagtgg tggtagcaca      240

agctacgcac agaagttcca gggcagagtc accatgacca gggacacgtc cacgagcaca      300

gtctacatgg agctgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcgaga      360

tcggatcggg gaattaccgc cacggacgct tttgatatct ggggccaagg gacaatggtc      420

accgtctctt caggcggagg aggctccggg ggaggaggtt ccgggggcgg gggttcccag      480

tctgtgctga ctcagccacc ctcggtgtca gtggccccag ggcggatggc caagattacc      540

tgtgggggaa gtgacattgg aaataaaaat gtccactggt atcagcagaa gccaggccag      600

gcccctgtcc tggttgtcta tgatgattac gaccggccct cagggatccc tgagcgattc      660

tctggctcca actctgggga cgcggccacc ctgacgatca gcacggtcga agtcggggat      720

gaggccgact atttctgtca ggtgtgggac ggtagtggtg atccttattg gatgttcggc      780

ggagggaccc agctcaccgt tttaggtgcg gccgcaacta ccacccctgc ccctcggccg      840

ccgactccgg ccccaaccat cgcaagccaa cccctctcct tgcgccccga agcttgccgc      900

ccggccgcgg gtggagccgt gcatacccgg gggctggact ttgcctgcga tatctacatt      960

tgggccccgc tggccggcac ttgcggcgtg ctcctgctgt cgctggtcat caccctttac     1020

tgcaagaggg gccggaagaa gctgctttac atcttcaagc agccgttcat gcggcccgtg     1080

cagacgactc aggaagagga cggatgctcg tgcagattcc ctgaggagga agagggggga     1140

tgcgaactgc gcgtcaagtt ctcacggtcc gccgacgccc ccgcatatca acagggccag     1200

aatcagctct acaacgagct gaacctggga aggagagagg agtacgacgt gctggacaag     1260

cgacgcggac gcgacccgga gatggggggg aaaccacggc ggaaaaaccc tcaggaagga     1320

ctgtacaacg aactccagaa agacaagatg gcggaagcct actcagaaat cgggatgaag     1380

ggagagcgga ggaggggaaa gggtcacgac gggctgtacc agggactgag caccgccact     1440

aaggatacct acgatgcctt gcatatgcaa gcactcccac cccgg                     1485


<210>  22
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG2065_(LP-M19217-1-CD8 TM-41BB-CD3 zeta)

<400>  22

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Leu Ile Asn Pro Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
145                 150                 155                 160 


Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Arg Met 
                165                 170                 175     


Ala Lys Ile Thr Cys Gly Gly Ser Asp Ile Gly Asn Lys Asn Val His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp 
        195                 200                 205             


Asp Tyr Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn 
    210                 215                 220                 


Ser Gly Asp Ala Ala Thr Leu Thr Ile Ser Thr Val Glu Val Gly Asp 
225                 230                 235                 240 


Glu Ala Asp Tyr Phe Cys Gln Val Trp Asp Gly Ser Gly Asp Pro Tyr 
                245                 250                 255     


Trp Met Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  23
<211>  1485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG2066 _(LP-M19217-2-CD8 TM-41BB-CD3 zeta)

<400>  23
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggagg tccagctggt acagtctgga gctgaggtga agaagcctgg ggcctcagtg      120

aaggtctcct gcaaggcttc cggatacacc ttcaccagct actacatgca ctgggtgcga      180

caggcccctg gacaagggtt tgagtggatg ggattaatca accctagtgg tagtagcaca      240

agctacgcac agaagttcca gggcagagtc accatgacca gggacacgtc cacgagcaca      300

gtctacatgg agctgagcaa cctgagatct gaggacacgg ccgtgtatta ctgtgcgaga      360

tcggatcggg gaattaccgc cacggacgct tttgatatct ggggccaagg gacaatggtc      420

accgtctctt caggcggagg aggctccggg ggaggaggtt ccgggggcgg gggttcccag      480

tctgtgctga ctcagccacc ctcggtgcca gtggccccag ggcagacggc caagattatc      540

tgtgggggaa gtgacattgg aaataaaaat gtccactggt accagcagaa gccaggccag      600

gcccctgtcc tggtcgtcta tgatgactac gaccggccct cagggatccc tgagcgattc      660

tctggctcca actctgggga cgcggccacc ctgacgatca gcacggttga agtcggggat      720

gaggccgact atttctgtca ggtgtgggac ggtagtggtg atccttattg ggtgttcggc      780

ggagggaccc agctcaccgt cttaggtgcg gccgcaacta ccacccctgc ccctcggccg      840

ccgactccgg ccccaaccat cgcaagccaa cccctctcct tgcgccccga agcttgccgc      900

ccggccgcgg gtggagccgt gcatacccgg gggctggact ttgcctgcga tatctacatt      960

tgggccccgc tggccggcac ttgcggcgtg ctcctgctgt cgctggtcat caccctttac     1020

tgcaagaggg gccggaagaa gctgctttac atcttcaagc agccgttcat gcggcccgtg     1080

cagacgactc aggaagagga cggatgctcg tgcagattcc ctgaggagga agagggggga     1140

tgcgaactgc gcgtcaagtt ctcacggtcc gccgacgccc ccgcatatca acagggccag     1200

aatcagctct acaacgagct gaacctggga aggagagagg agtacgacgt gctggacaag     1260

cgacgcggac gcgacccgga gatggggggg aaaccacggc ggaaaaaccc tcaggaagga     1320

ctgtacaacg aactccagaa agacaagatg gcggaagcct actcagaaat cgggatgaag     1380

ggagagcgga ggaggggaaa gggtcacgac gggctgtacc agggactgag caccgccact     1440

aaggatacct acgatgcctt gcatatgcaa gcactcccac cccgg                     1485


<210>  24
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG2066 _(LP-M19217-2-CD8 TM-41BB-CD3 zeta)

<400>  24

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Phe Glu Trp Met Gly Leu Ile Asn Pro Ser Gly Ser Ser Thr 
65                  70                  75                  80  


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Asn Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
145                 150                 155                 160 


Ser Val Leu Thr Gln Pro Pro Ser Val Pro Val Ala Pro Gly Gln Thr 
                165                 170                 175     


Ala Lys Ile Ile Cys Gly Gly Ser Asp Ile Gly Asn Lys Asn Val His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp 
        195                 200                 205             


Asp Tyr Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn 
    210                 215                 220                 


Ser Gly Asp Ala Ala Thr Leu Thr Ile Ser Thr Val Glu Val Gly Asp 
225                 230                 235                 240 


Glu Ala Asp Tyr Phe Cys Gln Val Trp Asp Gly Ser Gly Asp Pro Tyr 
                245                 250                 255     


Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  25
<211>  1485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG2067_(LP-M19217-7-CD8 TM-41BB-CD3 zeta)

<400>  25
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggagg tccagctggt acagtctgga gctgaggtga acaagcctgg tgcctcagtg      120

aaggtctcct gcaaggcttc tggatacacc ttcaccagct actatatgca ctgggtgcga      180

caggcccctg gacaagggct tgagtggatg ggaatgatca accctagtgg tggtagcaca      240

agctacgcac agaagttcca gggcagagtc accatgacca gggacacgtc cacgagcaca      300

gtctacatgg agctgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcgaga      360

tcggatcggg gaattacctc cacggacgct tttgatatct ggggccaagg gacaatggtc      420

accgtctctt caggcggagg aggctccggg ggaggaggtt ccgggggcgg gggttcccag      480

tctgtgctga ctcagccacc ctcggtgtca ttggccccag ggcagacggc caagattacc      540

tgtgggggaa gtgacattgg aaataaaaat gtccactggt accagcagaa gccaggccag      600

gcccctgtcc tagtcgtcta tgatgattac aaccggccct cagggatccc tgagcgattc      660

tctggctcca actctgggga ctcagccacc ctgacgatca gcacggtcga agtcggggat      720

gaggccgact atttctgtca ggtgtgggac ggtagtggtg atccttattg ggtgttcggc      780

ggagggaccc agctcaccgt tttaggtgcg gccgcaacta ccacccctgc ccctcggccg      840

ccgactccgg ccccaaccat cgcaagccaa cccctctcct tgcgccccga agcttgccgc      900

ccggccgcgg gtggagccgt gcatacccgg gggctggact ttgcctgcga tatctacatt      960

tgggccccgc tggccggcac ttgcggcgtg ctcctgctgt cgctggtcat caccctttac     1020

tgcaagaggg gccggaagaa gctgctttac atcttcaagc agccgttcat gcggcccgtg     1080

cagacgactc aggaagagga cggatgctcg tgcagattcc ctgaggagga agagggggga     1140

tgcgaactgc gcgtcaagtt ctcacggtcc gccgacgccc ccgcatatca acagggccag     1200

aatcagctct acaacgagct gaacctggga aggagagagg agtacgacgt gctggacaag     1260

cgacgcggac gcgacccgga gatggggggg aaaccacggc ggaaaaaccc tcaggaagga     1320

ctgtacaacg aactccagaa agacaagatg gcggaagcct actcagaaat cgggatgaag     1380

ggagagcgga ggaggggaaa gggtcacgac gggctgtacc agggactgag caccgccact     1440

aaggatacct acgatgcctt gcatatgcaa gcactcccac cccgg                     1485


<210>  26
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG2067 _(LP-M19217-7-CD8 TM-41BB-CD3 zeta)

<400>  26

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Asn Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Met Ile Asn Pro Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Arg Gly Ile Thr Ser Thr 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
145                 150                 155                 160 


Ser Val Leu Thr Gln Pro Pro Ser Val Ser Leu Ala Pro Gly Gln Thr 
                165                 170                 175     


Ala Lys Ile Thr Cys Gly Gly Ser Asp Ile Gly Asn Lys Asn Val His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp 
        195                 200                 205             


Asp Tyr Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn 
    210                 215                 220                 


Ser Gly Asp Ser Ala Thr Leu Thr Ile Ser Thr Val Glu Val Gly Asp 
225                 230                 235                 240 


Glu Ala Asp Tyr Phe Cys Gln Val Trp Asp Gly Ser Gly Asp Pro Tyr 
                245                 250                 255     


Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  27
<211>  1485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG2068_(LP-M19217-23-CD8 TM-41BB-CD3 zeta)

<400>  27
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggagg tccagctggt acagtctgga gctgaggtga agaagcctgg ggcctcagtg      120

aaggtctcct gcaaggcatc tggatacacc ttcaccggct actatatgca ctgggtgcgg      180

caggcccctg gacaagggct tgagtggata ggattaatca accctagtgg tggtagcaca      240

agctacgaac agaagttcca gggcagagtc gccatgacca gggacacgtc aacgagcaca      300

gtctacatgg agctgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcgaga      360

tcggatcggg gaattaccgc cacggacgct tttgatatct ggggccaagg gacaatggtc      420

accgtctctt caggcggagg aggctccggg ggaggaggtt ccgggggcgg gggttcccag      480

tctgtgctga ctcagccacc ctcggtgtca gtggccccag ggcagacggc caagattacc      540

tgtgggggaa gtgacattgg agataaaaat gtccactggt accagcagaa gccaggccag      600

gcccctgtcc tggtcgtcta tgatgattac gaccggccct cagggatccc tgagcgattc      660

tctggctcca actctgggga cgcggccacc ctgacgatca gcacggtcga agtcggggat      720

gaggccgact atttctgtca ggtgtgggac ggtattggtg atccctattg ggtgttcggc      780

ggagggaccc agctcaccgt tttaggtgcg gccgcaacta ccacccctgc ccctcggccg      840

ccgactccgg ccccaaccat cgcaagccaa cccctctcct tgcgccccga agcttgccgc      900

ccggccgcgg gtggagccgt gcatacccgg gggctggact ttgcctgcga tatctacatt      960

tgggccccgc tggccggcac ttgcggcgtg ctcctgctgt cgctggtcat caccctttac     1020

tgcaagaggg gccggaagaa gctgctttac atcttcaagc agccgttcat gcggcccgtg     1080

cagacgactc aggaagagga cggatgctcg tgcagattcc ctgaggagga agagggggga     1140

tgcgaactgc gcgtcaagtt ctcacggtcc gccgacgccc ccgcatatca acagggccag     1200

aatcagctct acaacgagct gaacctggga aggagagagg agtacgacgt gctggacaag     1260

cgacgcggac gcgacccgga gatggggggg aaaccacggc ggaaaaaccc tcaggaagga     1320

ctgtacaacg aactccagaa agacaagatg gcggaagcct actcagaaat cgggatgaag     1380

ggagagcgga ggaggggaaa gggtcacgac gggctgtacc agggactgag caccgccact     1440

aaggatacct acgatgcctt gcatatgcaa gcactcccac cccgg                     1485


<210>  28
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG2068 _(LP-M19217-23-CD8 TM-41BB-CD3 zeta)

<400>  28

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Ile Gly Leu Ile Asn Pro Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Ser Tyr Glu Gln Lys Phe Gln Gly Arg Val Ala Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
145                 150                 155                 160 


Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr 
                165                 170                 175     


Ala Lys Ile Thr Cys Gly Gly Ser Asp Ile Gly Asp Lys Asn Val His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp 
        195                 200                 205             


Asp Tyr Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn 
    210                 215                 220                 


Ser Gly Asp Ala Ala Thr Leu Thr Ile Ser Thr Val Glu Val Gly Asp 
225                 230                 235                 240 


Glu Ala Asp Tyr Phe Cys Gln Val Trp Asp Gly Ile Gly Asp Pro Tyr 
                245                 250                 255     


Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  29
<211>  1485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG2069_(LP-M19217-29-CD8 TM-41BB-CD3 zeta)

<400>  29
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggagg tccagctagt acagtctgga gctgaggtga agaagcctgg ggcctcagtg      120

aaggtctcct gcaaggcttc tggatacacc ttcaccagct actatatgca ctgggtgcga      180

caggcccctg gacaagggct tgagtggatg ggaatgatca accctagtgg tggtagcaca      240

agctacgcac agaagttcca gggcagagtc accatgacca gggacacgtc cacgagcaca      300

gtctacatgg agctgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcgaga      360

tcggatcggg gaattaccgc cacggacgct tttgatatct ggggccaagg gacaatggtc      420

accgtctctt caggcggagg aggctccggg ggaggaggtt ccgggggcgg gggttcccag      480

tctgtgctga ctcagccacc ctcggtgtca gtggccccag ggcagacggc caagattacc      540

tgtgggggaa gtgacattgg aaataaaaat gcccactggt accagcagaa gccaggccag      600

gcccctgtcc tggtcgtcta tgatgattac gaccggccct cagggatctc tgagcgattc      660

tctggctcca actctgggga cgcggccacc ctgacgatca gcacggtcga agtcggggat      720

gaggccgact atttctgtca ggtgtgggac ggtagtggtg atcctttttg ggtgttcggc      780

ggagggaccc agctcaccgt tttaggtgcg gccgcaacta ccacccctgc ccctcggccg      840

ccgactccgg ccccaaccat cgcaagccaa cccctctcct tgcgccccga agcttgccgc      900

ccggccgcgg gtggagccgt gcatacccgg gggctggact ttgcctgcga tatctacatt      960

tgggccccgc tggccggcac ttgcggcgtg ctcctgctgt cgctggtcat caccctttac     1020

tgcaagaggg gccggaagaa gctgctttac atcttcaagc agccgttcat gcggcccgtg     1080

cagacgactc aggaagagga cggatgctcg tgcagattcc ctgaggagga agagggggga     1140

tgcgaactgc gcgtcaagtt ctcacggtcc gccgacgccc ccgcatatca acagggccag     1200

aatcagctct acaacgagct gaacctggga aggagagagg agtacgacgt gctggacaag     1260

cgacgcggac gcgacccgga gatggggggg aaaccacggc ggaaaaaccc tcaggaagga     1320

ctgtacaacg aactccagaa agacaagatg gcggaagcct actcagaaat cgggatgaag     1380

ggagagcgga ggaggggaaa gggtcacgac gggctgtacc agggactgag caccgccact     1440

aaggatacct acgatgcctt gcatatgcaa gcactcccac cccgg                     1485


<210>  30
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG2069 _(LP-M19217-29-CD8 TM-41BB-CD3 zeta)

<400>  30

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Met Ile Asn Pro Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
145                 150                 155                 160 


Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr 
                165                 170                 175     


Ala Lys Ile Thr Cys Gly Gly Ser Asp Ile Gly Asn Lys Asn Ala His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp 
        195                 200                 205             


Asp Tyr Asp Arg Pro Ser Gly Ile Ser Glu Arg Phe Ser Gly Ser Asn 
    210                 215                 220                 


Ser Gly Asp Ala Ala Thr Leu Thr Ile Ser Thr Val Glu Val Gly Asp 
225                 230                 235                 240 


Glu Ala Asp Tyr Phe Cys Gln Val Trp Asp Gly Ser Gly Asp Pro Phe 
                245                 250                 255     


Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  31
<211>  1485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG2070_(LP-M19217-38-CD8 TM-41BB-CD3 zeta)

<400>  31
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggagg tccagctggt acagtctgga gctgaggtga agaggcctgg ggcctcagtg      120

aaggtctcct gcaaggcttc tggatacacc ttcaccagct actatatgca ctgggtgcga      180

caggcccctg gacgagggct tgagtggatg ggattaatca accctagtgg tggtagcaca      240

agctacgcac aggagttcca gggcagagtc accatgacca gggacatgtc cacgagcaca      300

gtctacatgg agctgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcgaga      360

tcggatcggg gaattagcgc cacggacgct tttgatatct ggggccaagg gacaatggtc      420

accgtctctt caggcggagg aggctccggg ggaggaggtt ccgggggcgg gggttcccag      480

tctgtgctga ctcagccacc ctcggtgtca gtggccccag ggcagatggc caagattacc      540

tgtgggggaa gtgacattgg aaataaaaat gtccactggt accagcagaa gccaggccag      600

gcccctgtcc tggtcgtcta tgatgattac aaccggccct cagggatccc tgagcgattc      660

tctggctcca actctgggga cgcggccacc ctgacgatca gcacggtcga agtcggggat      720

gaggccgact atttctgtca ggtatgggac ggtagtggtg atccttattg ggtgttcggc      780

ggagggaccc agctcaccga tttaggtgcg gccgcaacta ccacccctgc ccctcggccg      840

ccgactccgg ccccaaccat cgcaagccaa cccctctcct tgcgccccga agcttgccgc      900

ccggccgcgg gtggagccgt gcatacccgg gggctggact ttgcctgcga tatctacatt      960

tgggccccgc tggccggcac ttgcggcgtg ctcctgctgt cgctggtcat caccctttac     1020

tgcaagaggg gccggaagaa gctgctttac atcttcaagc agccgttcat gcggcccgtg     1080

cagacgactc aggaagagga cggatgctcg tgcagattcc ctgaggagga agagggggga     1140

tgcgaactgc gcgtcaagtt ctcacggtcc gccgacgccc ccgcatatca acagggccag     1200

aatcagctct acaacgagct gaacctggga aggagagagg agtacgacgt gctggacaag     1260

cgacgcggac gcgacccgga gatggggggg aaaccacggc ggaaaaaccc tcaggaagga     1320

ctgtacaacg aactccagaa agacaagatg gcggaagcct actcagaaat cgggatgaag     1380

ggagagcgga ggaggggaaa gggtcacgac gggctgtacc agggactgag caccgccact     1440

aaggatacct acgatgcctt gcatatgcaa gcactcccac cccgg                     1485


<210>  32
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG2070 _(LP-M19217-38-CD8 TM-41BB-CD3 zeta)

<400>  32

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Arg Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Arg Gly Leu Glu Trp Met Gly Leu Ile Asn Pro Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Ser Tyr Ala Gln Glu Phe Gln Gly Arg Val Thr Met Thr Arg Asp Met 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Arg Gly Ile Ser Ala Thr 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
145                 150                 155                 160 


Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Met 
                165                 170                 175     


Ala Lys Ile Thr Cys Gly Gly Ser Asp Ile Gly Asn Lys Asn Val His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp 
        195                 200                 205             


Asp Tyr Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn 
    210                 215                 220                 


Ser Gly Asp Ala Ala Thr Leu Thr Ile Ser Thr Val Glu Val Gly Asp 
225                 230                 235                 240 


Glu Ala Asp Tyr Phe Cys Gln Val Trp Asp Gly Ser Gly Asp Pro Tyr 
                245                 250                 255     


Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Asp Leu Gly Ala Ala Ala 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  33
<211>  1485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTG2071_(LP-M19217-40-CD8 TM-41BB-CD3 zeta)

<400>  33
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggagg tccagctggt acagtctgga gctgaggtga agaggcctgg ggcctcagtg      120

aaggtctcct gcaaggcttc tggatacacc ttcaccagct actatatgca ctgggtgcga      180

caggcccctg gacaagggct tgtgtggatg ggattaatca accctagtgg tggcagcaca      240

agctacgcac agaagttcca gggcagagtc accatgacca gggacacgtc cacgagcaca      300

gtctacatgg agctgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcgaga      360

tcggatcggg gaattaccgc cacggacgct tttgatatct ggggccaagg gacaatggtc      420

accgtctctt caggcggagg aggctccggg ggaggaggtt ccgggggcgg gggttcccag      480

tctgtgctga ctcagccacc ctcggtctca gtggccccag ggcagacggc caagactacc      540

tgtgggggaa gtgacattgg aaataaaaat gtccactggt accagcagaa gccaggccag      600

gcccctgtcc tggtcgtcta tgatgattac gaccggccct cagggatccc tgagcgattc      660

tctggctcca actctgggga cgcggccacc ctgacgatca gcacggtcga agtcggggat      720

gaggccgact atgtctgtca ggtgtgggac ggtagtggtg atccttattg ggtgttcggc      780

ggagggaccc agctcaccgt tttaggtgcg gccgcaacta ccacccctgc ccctcggccg      840

ccgactccgg ccccaaccat cgcaagccaa cccctctcct tgcgccccga agcttgccgc      900

ccggccgcgg gtggagccgt gcatacccgg gggctggact ttgcctgcga tatctacatt      960

tgggccccgc tggccggcac ttgcggcgtg ctcctgctgt cgctggtcat caccctttac     1020

tgcaagaggg gccggaagaa gctgctttac atcttcaagc agccgttcat gcggcccgtg     1080

cagacgactc aggaagagga cggatgctcg tgcagattcc ctgaggagga agagggggga     1140

tgcgaactgc gcgtcaagtt ctcacggtcc gccgacgccc ccgcatatca acagggccag     1200

aatcagctct acaacgagct gaacctggga aggagagagg agtacgacgt gctggacaag     1260

cgacgcggac gcgacccgga gatggggggg aaaccacggc ggaaaaaccc tcaggaagga     1320

ctgtacaacg aactccagaa agacaagatg gcggaagcct actcagaaat cgggatgaag     1380

ggagagcgga ggaggggaaa gggtcacgac gggctgtacc agggactgag caccgccact     1440

aaggatacct acgatgcctt gcatatgcaa gcactcccac cccgg                     1485


<210>  34
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LTG2071 _(LP-M19217-40-CD8 TM-41BB-CD3 zeta)

<400>  34

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Arg Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Val Trp Met Gly Leu Ile Asn Pro Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Arg Gly Ile Thr Ala Thr 
        115                 120                 125             


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
145                 150                 155                 160 


Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr 
                165                 170                 175     


Ala Lys Thr Thr Cys Gly Gly Ser Asp Ile Gly Asn Lys Asn Val His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp 
        195                 200                 205             


Asp Tyr Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn 
    210                 215                 220                 


Ser Gly Asp Ala Ala Thr Leu Thr Ile Ser Thr Val Glu Val Gly Asp 
225                 230                 235                 240 


Glu Ala Asp Tyr Val Cys Gln Val Trp Asp Gly Ser Gly Asp Pro Tyr 
                245                 250                 255     


Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Ala Ala Ala 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  35
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA CD8 transmembrane domain

<400>  35
atttgggccc cgctggccgg cacttgcggc gtgctcctgc tgtcgctggt catcaccctt       60

tactgc                                                                  66


<210>  36
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane domain

<400>  36

Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
1               5                   10                  15      


Val Ile Thr Leu Tyr Cys 
            20          


<210>  37
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA CD8 hinge domain

<400>  37
actaccaccc ctgcccctcg gccgccgact ccggccccaa ccatcgcaag ccaacccctc       60

tccttgcgcc ccgaagcttg ccgcccggcc gcgggtggag ccgtgcatac ccgggggctg      120

gactttgcct gcgatatcta c                                                141


<210>  38
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 hinge domain

<400>  38

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45      


<210>  39
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge and  transmembrane region of CD8.alpha. (NCBI RefSeq: 
       NP.sub.--001759.3)

<400>  39

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  40
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  signaling domain of 4-1BB

<400>  40
aagaggggcc ggaagaagct gctttacatc ttcaagcagc cgttcatgcg gcccgtgcag       60

acgactcagg aagaggacgg atgctcgtgc agattccctg aggaggaaga ggggggatgc      120

gaactg                                                                 126


<210>  41
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signaling domain of 4-1BB

<400>  41

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  42
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  intracellular signaling domain of CD3-zeta

<400>  42
cgcgtcaagt tctcacggtc cgccgacgcc cccgcatatc aacagggcca gaatcagctc       60

tacaacgagc tgaacctggg aaggagagag gagtacgacg tgctggacaa gcgacgcgga      120

cgcgacccgg agatgggggg gaaaccacgg cggaaaaacc ctcaggaagg actgtacaac      180

gaactccaga aagacaagat ggcggaagcc tactcagaaa tcgggatgaa gggagagcgg      240

aggaggggaa agggtcacga cgggctgtac cagggactga gcaccgccac taaggatacc      300

tacgatgcct tgcatatgca agcactccca ccccgg                                336


<210>  43
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3-zeta

<400>  43

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  44
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  intracellular signaling domain of CD3-zeta, variant

<400>  44
cgcgtcaagt tctcacggtc cgccgacgcc cccgcatata aacagggcca gaatcagctc       60

tacaacgagc tgaacctggg aaggagagag gagtacgacg tgctggacaa gcgacgcgga      120

cgcgacccgg agatgggggg gaaaccacgg cggaaaaacc ctcaggaagg actgtacaac      180

gaactccaga aagacaagat ggcggaagcc tactcagaaa tcgggatgaa gggagagcgg      240

aggaggggaa agggtcacga cgggctgtac cagggactga gcaccgccac taaggatacc      300

tacgatgcct tgcatatgca agcactccca ccccgg                                336


<210>  45
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3-zeta signaling domain, variant

<400>  45

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  46
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ScFv CD19 (FMC63)

<400>  46
gacattcaga tgactcagac cacctcttcc ttgtccgcgt cactgggaga cagagtgacc       60

atctcgtgtc gcgcaagcca ggatatctcc aagtacctga actggtacca acagaagccc      120

gacgggactg tgaagctgct gatctaccac acctcacgcc tgcacagcgg agtgccaagc      180

agattctccg gctccggctc gggaaccgat tactcgctta ccattagcaa cctcgagcag      240

gaggacatcg ctacctactt ctgccagcaa ggaaataccc tgccctacac cttcggcgga      300

ggaaccaaat tggaaatcac cggcggagga ggctccgggg gaggaggttc cgggggcggg      360

ggttccgaag tgaagctcca ggagtccggc cccggcctgg tggcgccgtc gcaatcactc      420

tctgtgacct gtaccgtgtc gggagtgtcc ctgcctgatt acggcgtgag ctggattcgg      480

cagccgccgc ggaagggcct ggaatggctg ggtgtcatct ggggatccga gactacctac      540

tacaactcgg ccctgaagtc ccgcctgact atcatcaaag acaactcgaa gtcccaggtc      600

tttctgaaga tgaactccct gcaaactgac gacaccgcca tctattactg tgctaagcac      660

tactactacg gtggaagcta tgctatggac tactgggggc aaggcacttc ggtgactgtg      720

tcaagc                                                                 726


<210>  47
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ScFv CD19 (FMC63)

<400>  47

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  48
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD33 ScFv (LTG1936)

<400>  48
caggtgcagc tggtgcaatc tggggcagag gtgaaaaagc ccggggagtc tctgaggatc       60

tcctgtaagg gttctggatt cagttttccc acctactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagactagtt      300

ggagatggct acaatacggg ggcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttcaggag gtggcgggtc tggtggtggc ggtagcggtg gtggcggatc cgatattgtg      420

atgacccaca ctccactctc tctgtccgtc acccctggac agccggcctc catctcctgc      480

aagtctagtc agagcctcct gcatagtaat ggaaagacct atttgtattg gtacctgcag      540

aagccaggcc agcctccaca gctcctgatc tatggagctt ccaaccggtt ctctggagtg      600

ccagacaggt tcagtggcag cgggtcaggg acagatttca cactgaaaat cagccgggtg      660

gaggctgagg atgttggggt ttattactgc atgcaaagta tacagcttcc tatcaccttc      720

ggccaaggga cacgactgga gattaaa                                          747


<210>  49
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 ScFv (LTG1936)

<400>  49

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Phe Ser Phe Pro Thr Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Val Gly Asp Gly Tyr Asn Thr Gly Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr His Thr 
    130                 135                 140                 


Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Leu Leu His Ser Asn Gly Lys Thr Tyr Leu Tyr 
                165                 170                 175     


Trp Tyr Leu Gln Lys Pro Gly Gln Pro Pro Gln Leu Leu Ile Tyr Gly 
            180                 185                 190         


Ala Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp 
    210                 215                 220                 


Val Gly Val Tyr Tyr Cys Met Gln Ser Ile Gln Leu Pro Ile Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Arg Leu Glu Ile Lys 
                245                 


<210>  50
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-mesothelin ScFv (LTG1904)

<400>  50
gaggtccagc tggtacagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag cataggctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagattta      300

tcgtcagtgg ctggaccctt taactactgg ggccagggca ccctggtcac cgtctcctca      360

ggaggtggcg ggtctggtgg aggcggtagc ggcggtggcg gatcctcttc tgagctgact      420

caggaccctg ctgtgtctgt ggccttggga cagacagtca ggatcacatg ccaaggagac      480

agcctcagaa gctattatgc aagctggtac cagcagaagc caggacaggc ccctgtactt      540

gtcatctatg gtaaaaacaa ccggccctca gggatcccag accgattctc tggctccagc      600

tcaggaaaca cagcttcctt gaccatcact ggggctcagg cggaggatga ggctgactat      660

tactgtaact cccgggacag cagtggtaac catctggtat tcggcggagg cacccagctg      720

accgtcctcg gt                                                          732


<210>  51
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-mesothelin ScFv (LTG1904)

<400>  51

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Ser Ser Val Ala Gly Pro Phe Asn Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
                165                 170                 175     


Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser 
    210                 215                 220                 


Arg Asp Ser Ser Gly Asn His Leu Val Phe Gly Gly Gly Thr Gln Leu 
225                 230                 235                 240 


Thr Val Leu Gly 
                


