                         SEQUENCE LISTING

<110>  RADIMMUNE THERAPEUTICS, INC.
 
<120>  MELANIN ANTIBODIES AND USES THEREOF

<130>  RADM-002/01WO 328309-2005

<150>  US 62/558,230
<151>  2017-09-13

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain of a melanin Chimeric Antibody (8C3-hIgG1)

<400>  1

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ala His Asn His Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Thr Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Gly Gly Tyr Tyr Gly Asn Tyr Gly Phe Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  2
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain of a melanin Chimeric Antibody (8C3-hKappa)

<400>  2

Asp Ile Leu Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Thr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  3
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain of a melanin Humanized Antibody (8C3-HE-VH3A-hIgG1)

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Arg Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ala His Asn His Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Thr Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Gly Gly Tyr Tyr Gly Asn Tyr Gly Phe Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  4
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain of a melanin Humanized Antibody (8C3-HE-VH3B-hIgG1)

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Arg Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ala His Asn His Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Gly Gly Tyr Tyr Gly Asn Tyr Gly Phe Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  5
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain of a melanin Humanized Antibody (8C3-HE-VK1A-hKappa)

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Thr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Val Gln Ala Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  6
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain of a melanin Humanized Antibody (8C3-HE-VK1B-hKappa)

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Thr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Gln Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Val Gln Ala Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  7
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain of a melanin Humanized Antibody (8C3-HE-VK4-hKappa)

<400>  7

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Thr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Arg Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Val Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  8

Phe Thr Phe Ser Asp Ala Trp Met Asp 
1               5                   


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  9

Trp Val Ala Glu Ile Arg Ser Lys Ala His Asn His Ala Thr Tyr Tyr 
1               5                   10                  15      


<210>  10
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  10

Arg Gly Gly Tyr Tyr Gly Asn Tyr Gly Phe Phe Ala Tyr 
1               5                   10              


<210>  11
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  11

Glu Ser Val Asp Ser Tyr Gly Thr Ser Phe Met His 
1               5                   10          


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  12

Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser 
1               5                   10      


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  13

Leu Leu Ile Tyr Leu Ala Ser Asn Leu Gln Ser 
1               5                   10      


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  14

Leu Leu Ile Tyr Leu Ala Ser Asn Arg Glu Ser 
1               5                   10      


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  15

Gln Gln Asn Asn Glu Tyr Pro Tyr 
1               5               


<210>  16
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  16

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg 
            20      


<210>  17
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal peptide nucleotide sequence

<400>  17
atggacatga gagtgccggc gcaactgctc ggcctgctgt tgctgtggct gaggggagcc       60

agatgc                                                                  66


<210>  18
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAB11 625.69.1 heavy chain of a chimeric melanin antibody gene 
       (8C3-hIgG1)

<400>  18
gaagtgcagc tcgaggaatc cggaggagga ctggtgcagc ctggcggaag catgaaggtg       60

tcatgcgcgg cttccggatt caccttctcg gacgcctgga tggattgggt cagacaaagc      120

cccgaaaaag gcctggaatg ggtggccgag attcggtcca aggcccataa ccacgccacc      180

tactacgccg agtccgtgaa ggggcgcttt actatctccc gggatgactc gaagtcgtcc      240

gtgtacctcc agatgaactc attgagggcc gaggacactg ggacctacta ctgtacccgc      300

ggaggctact acgggaacta tggtttcttc gcctactggg gccagggtac cctcgtgact      360

gtcagcgcgg ccagcaccaa gggccccagc gtgttcccac tggccccaag ctccaagtca      420

acctccggcg gaactgctgc gctgggctgc ttggtgaagg actacttccc cgaaccggtc      480

accgtgtcct ggaacagcgg agccctgacc tcgggagtcc acactttccc cgctgtgctg      540

cagtcgtccg gcctgtactc gctctcgtcc gtggtcactg tcccgtcctc gtccctgggt      600

actcagacct acatttgcaa cgtcaaccac aagccttcaa acacgaaagt ggacaagaag      660

gtcgagccga agtcctgcga caaaacccat acttgccctc cttgtccggc tcccgaactg      720

ctgggcggac cttccgtgtt cctcttcccg cctaagccga aagacaccct gatgatcagc      780

aggactccgg aagtgacatg cgtggtggtg gacgtgtcgc acgaggaccc ggaggtcaag      840

tttaattggt acgtggacgg agtggaagtc cacaacgcca agaccaagcc acgggaagaa      900

cagtacaatt ccacctatcg cgtggtgtcc gtgcttaccg tgcttcacca agactggctg      960

aacggaaagg agtacaagtg caaagtgtca aacaaagccc tgcctgcccc aatcgaaaag     1020

accatcagca aggccaaggg gcagcctcgg gaaccccaag tgtacactct cccgccgtca     1080

agagatgaac tgaccaagaa ccaagtgtcc ctcacttgtc tcgtgaaggg attctacccc     1140

tccgatatcg ccgtggagtg ggaatccaac gggcaacccg agaacaacta caagaccacc     1200

cctccggtgc ttgattccga tggctccttc ttcctctact ccaagctgac cgtggacaag     1260

tcaagatggc agcaggggaa cgtgttctcc tgctccgtca tgcacgaggc cctgcacaac     1320

cattacaccc agaagtctct gtcgctgagc ccgggaaaat aa                        1362


<210>  19
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAB2 625.48.2 light chain of a chimeric melanin antibody gene 
       (8C3-hKappa)

<400>  19
gacatcctga tgactcagtc acccgctagc cttgcggtgt ccctcggaca acgcgccacc       60

atctcctgtc gggcctccga atccgtggac tcctacggca cctccttcat gcactggtac      120

cagcagaagc caggacagcc tcccaagctg ttgatctatc tggcctcgaa tctggaatca      180

ggagtgccgg ctcggttcag cggctccgga tcacgcactg acttcacgct gaccattgac      240

cccgtggagg cagatgacgc cgcgacctac tactgccagc agaacaacga atacccttac      300

actttcggcg ggggtaccaa gctcgaaatc aagcggacag tggcagcccc atcggtgttc      360

attttcccgc cgtcggatga gcagctcaag tccggtactg cctccgtggt ctgcctgctg      420

aacaactttt accctcgcga agcgaaggtc caatggaaag tggataacgc cctccagtcc      480

ggaaactccc aggagtctgt caccgagcag gactcaaagg acagcactta ctccctgtcc      540

tcgactctga ccctgtcgaa ggcagattac gagaagcaca aagtgtacgc ctgcgaagtg      600

acccatcaag gcctttccag cccggtcacc aagagcttca atcgggggga gtgttag         657


<210>  20
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain of a melanin Humanized Antibody (8C3-HE-VK4-hKappa)

<400>  20
atggacatga gagtgccggc gcaactgctc ggcctgctgt tgctgtggct gaggggagcc       60

agatgcgaca tcgtgatgac tcagtcaccc gatagccttg cggtgtccct cggagaacgc      120

gccaccatca actgtaaagc ctccgaatcc gtggactcct acggcacctc cttcatgcac      180

tggtaccagc agaagccagg acagcctccc aagctgttga tctatctggc ctcgaatcgg      240

gaatcaggag tgccggaccg gttcagcggc tccggatcac gcactgactt cacgctgacc      300

attagccccg tgcaagcaga ggacgtggcg acctactact gccagcagaa caacgaatac      360

ccttacactt tcggccaggg taccaagctc gaaatcaagc ggacagtggc agccccatcg      420

gtgttcattt tcccgccgtc ggatgagcag ctcaagtccg gtactgcctc cgtggtctgc      480

ctgctgaaca acttttaccc tcgcgaagcg aaggtccaat ggaaagtgga taacgccctc      540

cagtccggaa actcccagga gtctgtcacc gagcaggact caaaggacag cacttactcc      600

ctgtcctcga ctctgaccct gtcgaaggca gattacgaga agcacaaagt gtacgcctgc      660

gaagtgaccc atcaaggcct ttccagcccg gtcaccaaga gcttcaatcg gggggagtgt      720

tagtaa                                                                 726


<210>  21
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain of a melanin Humanized Antibody (8C3-HE-VK1A-hKappa)

<400>  21
atggacatga gagtgccggc gcaactgctc ggcctgctgt tgctgtggct gaggggagcc       60

agatgcgaca tccagatgac tcagtcaccc tcgagcctta gcgtgtccct cggagatcgc      120

gccaccatca cctgtcgggc ctccgaatcc gtggactcct acggcacctc cttcatgcac      180

tggtaccagc agaagccagg aaagcctccc aagctgttga tctatctggc ctcgaatctg      240

gaatcaggag tgccgtcgcg gttcagcggc tccggatcac gcactgactt cacgctgacc      300

attagccccg tgcaagcaga ggactttgcg acctactact gccagcagaa caacgaatac      360

ccttacactt tcggccaggg taccaagctc gaaatcaagc ggacagtggc agccccatcg      420

gtgttcattt tcccgccgtc ggatgagcag ctcaagtccg gtactgcctc cgtggtctgc      480

ctgctgaaca acttttaccc tcgcgaagcg aaggtccaat ggaaagtgga taacgccctc      540

cagtccggaa actcccagga gtctgtcacc gagcaggact caaaggacag cacttactcc      600

ctgtcctcga ctctgaccct gtcgaaggca gattacgaga agcacaaagt gtacgcctgc      660

gaagtgaccc atcaaggcct ttccagcccg gtcaccaaga gcttcaatcg gggggagtgt      720

tagtaa                                                                 726


<210>  22
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain of a melanin Humanized Antibody (8C3-HE-VK1B-hKappa)

<400>  22
atggacatga gagtgccggc gcaactgctc ggcctgctgt tgctgtggct gaggggagcc       60

agatgcgaca tccagatgac tcagtcaccc tcgagcctta gcgtgtccgt gggagatcgc      120

gccaccatca cctgtcgggc ctccgaatcc gtggactcct acggcacctc cttcatgcac      180

tggtaccagc agaagccagg aaagcctccc aagctgttga tctatctggc ctcgaatctg      240

cagtcaggag tgccgtcgcg gttcagcggc tccggatcac gcactgactt cacgctgacc      300

attagccccg tgcaagcaga ggactttgcg acctactact gccagcagaa caacgaatac      360

ccttacactt tcggccaggg taccaagctc gaaatcaagc ggacagtggc agccccatcg      420

gtgttcattt tcccgccgtc ggatgagcag ctcaagtccg gtactgcctc cgtggtctgc      480

ctgctgaaca acttttaccc tcgcgaagcg aaggtccaat ggaaagtgga taacgccctc      540

cagtccggaa actcccagga gtctgtcacc gagcaggact caaaggacag cacttactcc      600

ctgtcctcga ctctgaccct gtcgaaggca gattacgaga agcacaaagt gtacgcctgc      660

gaagtgaccc atcaaggcct ttccagcccg gtcaccaaga gcttcaatcg gggggagtgt      720

tagtaa                                                                 726


<210>  23
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain of a melanin Humanized Antibody (8C3-HE-VH3A-hIgG1)

<400>  23
atggacatgc gcgtgccggc acaactgctg ggcctgctgc tgctttggct gcggggagct       60

agatgcgaag tgcagctcgt cgaatccgga ggaggactgg tgcagcctgg cggaagcatg      120

cgcgtgtcat gcgcggcttc cggattcacc ttctcggacg cctggatgga ttgggtcaga      180

caagcgcccg gcaaaggcct ggaatgggtg gccgagattc ggtccaaggc ccataaccac      240

gccacctact acgccgagtc cgtgaagggg cgctttacta tctcccggga tgactcgaag      300

tcgacggtgt acctccagat gaactcattg agggccgagg acactgggac ctactactgt      360

acccgcggag gctactacgg gaactatggt ttcttcgcct actggggcca gggtaccctc      420

gtgactgtca gcagcgccag caccaagggc cccagcgtgt tcccactggc cccaagctcc      480

aagtcaacct ccggcggaac tgctgcgctg ggctgcttgg tgaaggacta cttccccgaa      540

ccggtcaccg tgtcctggaa cagcggagcc ctgacctcgg gagtccacac tttccccgct      600

gtgctgcagt cgtccggcct gtactcgctc tcgtccgtgg tcactgtccc gtcctcgtcc      660

ctgggtactc agacctacat ttgcaacgtc aaccacaagc cttcaaacac gaaagtggac      720

aagaaggtcg agccgaagtc ctgcgacaaa acccatactt gccctccttg tccggctccc      780

gaactgctgg gcggaccttc cgtgttcctc ttcccgccta agccgaaaga caccctgatg      840

atcagcagga ctccggaagt gacatgcgtg gtggtggacg tgtcgcacga ggacccggag      900

gtcaagttta attggtacgt ggacggagtg gaagtccaca acgccaagac caagccacgg      960

gaagaacagt acaattccac ctatcgcgtg gtgtccgtgc ttaccgtgct tcaccaagac     1020

tggctgaacg gaaaggagta caagtgcaaa gtgtcaaaca aagccctgcc tgccccaatc     1080

gaaaagacca tcagcaaggc caaggggcag cctcgggaac cccaagtgta cactctcccg     1140

ccgtcaagag atgaactgac caagaaccaa gtgtccctca cttgtctcgt gaagggattc     1200

tacccctccg atatcgccgt ggagtgggaa tccaacgggc aacccgagaa caactacaag     1260

accacccctc cggtgcttga ttccgatggc tccttcttcc tctactccaa gctgaccgtg     1320

gacaagtcaa gatggcagca ggggaacgtg ttctcctgct ccgtcatgca cgaggccctg     1380

cacaaccatt acacccagaa gtctctgtcg ctgagcccgg gaaaataa                  1428


<210>  24
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain of a melanin Humanized Antibody (8C3-HE-VH3B-hIgG1)

<400>  24
atggacatgc gcgtgccggc acaactgctg ggcctgctgc tgctttggct gcggggagct       60

agatgcgaag tgcagctcgt ggaatccgga ggaggactgg tgcagcctgg cggaagcatg      120

cgcgtgtcat gcgcggcttc cggattcacc ttctcggacg cctggatgga ttgggtcaga      180

caagcgcccg gcaaaggcct ggaatgggtg gccgagattc ggtccaaggc ccataaccac      240

gccacctact acgccgactc cgtgaagggg cgctttacta tctcccggga taactcgaag      300

aataccgtgt acctccagat gaactcattg agggccgagg acactggggt ctactactgt      360

acccgcggag gctactacgg gaactatggt ttcttcgcct actggggcca gggtaccctc      420

gtgactgtca gcagcgccag caccaagggc cccagcgtgt tcccactggc cccaagctcc      480

aagtcaacct ccggcggaac tgctgcgctg ggctgcttgg tgaaggacta cttccccgaa      540

ccggtcaccg tgtcctggaa cagcggagcc ctgacctcgg gagtccacac tttccccgct      600

gtgctgcagt cgtccggcct gtactcgctc tcgtccgtgg tcactgtccc gtcctcgtcc      660

ctgggtactc agacctacat ttgcaacgtc aaccacaagc cttcaaacac gaaagtggac      720

aagaaggtcg agccgaagtc ctgcgacaaa acccatactt gccctccttg tccggctccc      780

gaactgctgg gcggaccttc cgtgttcctc ttcccgccta agccgaaaga caccctgatg      840

atcagcagga ctccggaagt gacatgcgtg gtggtggacg tgtcgcacga ggacccggag      900

gtcaagttta attggtacgt ggacggagtg gaagtccaca acgccaagac caagccacgg      960

gaagaacagt acaattccac ctatcgcgtg gtgtccgtgc ttaccgtgct tcaccaagac     1020

tggctgaacg gaaaggagta caagtgcaaa gtgtcaaaca aagccctgcc tgccccaatc     1080

gaaaagacca tcagcaaggc caaggggcag cctcgggaac cccaagtgta cactctcccg     1140

ccgtcaagag atgaactgac caagaaccaa gtgtccctca cttgtctcgt gaagggattc     1200

tacccctccg atatcgccgt ggagtgggaa tccaacgggc aacccgagaa caactacaag     1260

accacccctc cggtgcttga ttccgatggc tccttcttcc tctactccaa gctgaccgtg     1320

gacaagtcaa gatggcagca ggggaacgtg ttctcctgct ccgtcatgca cgaggccctg     1380

cacaaccatt acacccagaa gtctctgtcg ctgagcccgg gaaaataa                  1428


<210>  25
<211>  6833
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid encoding the Light Chain of a melanin Humanized Antibody 
       (8C3-HE-VK4-hKappa)

<400>  25
tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt       60

tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg      120

tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctgg      180

gaaattgtaa acgttaatat tttgttaaaa ttcgcgttaa atttttgtta aatcagctca      240

ttttttaacc aataggccga aatcggcaaa atcccttata aatcaaaaga atagaccgag      300

atagggttga gtgttgttcc agtttggaac aagagtccac tattaaagaa cgtggactcc      360

aacgtcaaag ggcgaaaaac cgtctatcag ggcgatggcc cactacgtga accatcaccc      420

taatcaagtt ttttggggtc gaggtgccgt aaagcactaa atcggaaccc taaagggagc      480

ccccgattta gagcttgacg gggaaagccg gcgaacgtgg cgagaaagga agggaagaaa      540

gcgaaaggag cgggcgctag ggcgctggca agtgtagcgg tcacgctgcg cgtaaccacc      600

acacccgccg cgcttaatgc gccgctacag ggcgcgtccc attcgccatt caggctgcgc      660

aactgttggg aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg      720

ggatgtgctg caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt      780

aaaacgacgg ccagtgagcg cgcgtaatac gactcactat agggcgaatt gggtaccggg      840

ccccccctcg aggtcgacgg tatcgataag cttgatatcg aattcgctgg gctgagaccc      900

gcagaggaag acgctctagg gatttgtccc ggactagcga gatggcaagg ctgaggacgg      960

gaggctgatt gagaggcgaa ggtacaccct aatctcaata caacccttgg agctaagcca     1020

gcaatggtag agggaagatt ctgcacgtcc cttccaggcg gcctccccgt caccacccac     1080

cccaacccgc cccgaccgga gctgagagta attcatacaa aaggactcgc ccctgccttg     1140

gggaatccca gggaccgtcg ttaaactccc actaacgtag aacccagaga tcgctgcgtt     1200

cccgccccct cacccgcccg ctctcgtcat cactgaggtg gagaagagca tgcgtgaggc     1260

tccggtgccc gtcagtgggc agagcgcaca tcgcccacag tccccgagaa gttgggggga     1320

ggggtcggca attgaaccgg tgcctagaga aggtggcgcg gggtaaactg ggaaagtgat     1380

gtcgtgtact ggctccgcct ttttcccgag ggtgggggag aaccgtatat aagtgcagta     1440

gtcgccgtga acgttctttt tcgcaacggg tttgccgcca gaacacaggt aagtgccgtg     1500

tgtggttccc gcgggcctgg cctctttacg ggttatggcc cttgcgtgcc ttgaattact     1560

tccacgcccc tggctgcagt acgtgattct tgatcccgag cttcgggttg aaagtgggtg     1620

ggagagttcg aggccttgcg cttaaggagc cccttcgcct cgtgcttgag ttgaggcctg     1680

gcttgggcgc tggggccgcc gcgtgcgaat ctggtggcac cttcgcgcct atctcgctgc     1740

tttcgataag tctctagcca tttaaaattt ttgatgacct gctgcgacgc tttttttctg     1800

gcaagatagt cttgtaaatg cgggccaaga tctgcacact ggtatttcgg tttttggggc     1860

cgcgggcggc gacggggccc gtgcgtccca gcgcacatgt tcggcgaggc ggggcctgcg     1920

agcgcggcca ccgagaatcg gacgggggta gtctcaagct ggccggcctg ctctggtgcc     1980

tggcctcgcg ccgccgtgta tcgccccgcc ctgggcggca aggctggccc ggtcggcacc     2040

agttgcgtga gcggaaagat ggccgcttcc cggccctgct gcagggagct caaaatggag     2100

gacgcggcgc tcgggagagc gggcgggtga gtcacccaca caaaggaaaa gggcctttcc     2160

gtcctcagcc gtcgcttcat gtgactccac ggagtaccgg gcgccgtcca ggcacctcga     2220

ttagttctcg agcttttgga gtacgtcgtc tttaggttgg ggggaggggt tttatgcgat     2280

ggagtttccc cacactgagt gggtggagac tgaagttagg ccagcttggc acttgatgta     2340

attctccttg gaatttgccc tttttgagtt tggatcttgg ttcattctca agcctcagac     2400

agtggttcaa agttttttcc ttccatttca ggtgtcgtga aaactacccc taaaagccaa     2460

atctagagcc accatggaca tgagagtgcc ggcgcaactg ctcggcctgc tgttgctgtg     2520

gctgagggga gccagatgcg acatcgtgat gactcagtca cccgatagcc ttgcggtgtc     2580

cctcggagaa cgcgccacca tcaactgtaa agcctccgaa tccgtggact cctacggcac     2640

ctccttcatg cactggtacc agcagaagcc aggacagcct cccaagctgt tgatctatct     2700

ggcctcgaat cgggaatcag gagtgccgga ccggttcagc ggctccggat cacgcactga     2760

cttcacgctg accattagcc ccgtgcaagc agaggacgtg gcgacctact actgccagca     2820

gaacaacgaa tacccttaca ctttcggcca gggtaccaag ctcgaaatca agcggacagt     2880

ggcagcccca tcggtgttca ttttcccgcc gtcggatgag cagctcaagt ccggtactgc     2940

ctccgtggtc tgcctgctga acaactttta ccctcgcgaa gcgaaggtcc aatggaaagt     3000

ggataacgcc ctccagtccg gaaactccca ggagtctgtc accgagcagg actcaaagga     3060

cagcacttac tccctgtcct cgactctgac cctgtcgaag gcagattacg agaagcacaa     3120

agtgtacgcc tgcgaagtga cccatcaagg cctttccagc ccggtcacca agagcttcaa     3180

tcggggggag tgttagtaat gaggatcccc ctattctata gtgtcaccta aatgctagag     3240

ctcgctgatc agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc     3300

ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg     3360

aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg     3420

acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta     3480

tggcttctga ggcggaaaga accagctggg gctcgagcgg ccgccccttc tgaggcggaa     3540

agaaccagct gtggaatgtg tgtcagttag ggtgtggaaa gtccccaggc tccccagcag     3600

gcagaagtat gcaaagcatg catctcaatt agtcagcaac caggtgtgga aagtccccag     3660

gctccccagc aggcagaagt atgcaaagca tgcatctcaa ttagtcagca accatagtcc     3720

cgcccctaac tccgcccatc ccgcccctaa ctccgcccag ttccgcccat tctccgcccc     3780

atggctgact aatttttttt atttatgcag aggccgaggc cgcctcggcc tctgagctat     3840

tccagaagta gtgaggaggc ttttttggag gcctaggctt ttgcaaaaaa gctagcttcc     3900

cgctgccatc atggttcgac cattgaactg catcgtcgcc gtgtcccaaa atatggggat     3960

tggcaagaac ggagacctac cctggcctcc gctcaggaac gagttcaagt acttccaaag     4020

aatgaccaca acctcttcag tggaaggtaa acagaatctg gtgattatgg gtaggaaaac     4080

ctggttctcc attcctgaga agaatcgacc tttaaaggac agaattaata tagttctcag     4140

tagagaactc aaagaaccac cacgaggagc tcattttctt gccaaaagtt tggatgatgc     4200

cttaagactt attgaacaac cggaattggc aagtaaagta gacatggttt ggatagtcgg     4260

aggcagttct gtttaccagg aagccatgaa tcaaccaggc caccttagac tctttgtgac     4320

aaggatcatg caggaatttg aaagtgacac gtttttccca gaaattgatt tggggaaata     4380

taaacttctc ccagaatacc caggcgtcct ctctgaggtc caggaggaaa aaggcatcaa     4440

gtataagttt gaagtctacg agaagaaaga ctaacaggaa gatgctttca agttctctgc     4500

tcccctccta aagctatgca tttttataag accatgggac ttttgctggc tttagatccc     4560

gcggagatcc agacatgata agatacattg atgagtttgg acaaaccaca actagaatgc     4620

agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat tgctttattt gtaaccatta     4680

taagctgcaa taaacaagtt aacaacaaca attgcattca ttttatgttt caggttcagg     4740

gggaggtgtg ggaggttttt taaagcaagt aaaacctcta caaatgtggt atggctgatt     4800

atgagctcca gcttttgttc cctttagtga gggttaattg cgcgcttggc gtaatcatgg     4860

tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa ttccacacaa catacgagcc     4920

ggaagcataa agtgtaaagc ctggggtgcc taatgagtga gctaactcac attaattgcg     4980

ttgcgctcac tgcccgcttt ccagtcggga aacctgtcgt gccagctgca ttaatgaatc     5040

ggccaacgcg cggggagagg cggtttgcgt attgggcgct cttccgcttc ctcgctcact     5100

gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat cagctcactc aaaggcggta     5160

atacggttat ccacagaatc aggggataac gcaggaaaga acatgtgagc aaaaggccag     5220

caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc     5280

cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta     5340

taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg     5400

ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc     5460

tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac     5520

gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac     5580

ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg     5640

aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga     5700

aggacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt     5760

agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag     5820

cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct     5880

gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt atcaaaaagg     5940

atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta aagtatatat     6000

gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc     6060

tgtctatttc gttcatccat agttgcctga ctccccgtcg tgtagataac tacgatacgg     6120

gagggcttac catctggccc cagtgctgca atgataccgc gagacccacg ctcaccggct     6180

ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag tggtcctgca     6240

actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt aagtagttcg     6300

ccagttaata gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt gtcacgctcg     6360

tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt tacatgatcc     6420

cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag     6480

ttggccgcag tgttatcact catggttatg gcagcactgc ataattctct tactgtcatg     6540

ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt ctgagaatag     6600

tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac gggataatac cgcgccacat     6660

agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa actctcaagg     6720

atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa ctgatcttca     6780

gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca aaa            6833


<210>  26
<211>  6833
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid encoding the Light Chain of a melanin Humanized Antibody 
       (8C3-HE-VK1A-hKappa)

<400>  26
cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg gggatgtgct gcaaggcgat       60

taagttgggt aacgccaggg ttttcccagt cacgacgttg taaaacgacg gccagtgagc      120

gcgcgtaata cgactcacta tagggcgaat tgggtaccgg gccccccctc gaggtcgacg      180

gtatcgataa gcttgatatc gaattcgctg ggctgagacc cgcagaggaa gacgctctag      240

ggatttgtcc cggactagcg agatggcaag gctgaggacg ggaggctgat tgagaggcga      300

aggtacaccc taatctcaat acaacccttg gagctaagcc agcaatggta gagggaagat      360

tctgcacgtc ccttccaggc ggcctccccg tcaccaccca ccccaacccg ccccgaccgg      420

agctgagagt aattcataca aaaggactcg cccctgcctt ggggaatccc agggaccgtc      480

gttaaactcc cactaacgta gaacccagag atcgctgcgt tcccgccccc tcacccgccc      540

gctctcgtca tcactgaggt ggagaagagc atgcgtgagg ctccggtgcc cgtcagtggg      600

cagagcgcac atcgcccaca gtccccgaga agttgggggg aggggtcggc aattgaaccg      660

gtgcctagag aaggtggcgc ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc      720

tttttcccga gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt      780

ttcgcaacgg gtttgccgcc agaacacagg taagtgccgt gtgtggttcc cgcgggcctg      840

gcctctttac gggttatggc ccttgcgtgc cttgaattac ttccacgccc ctggctgcag      900

tacgtgattc ttgatcccga gcttcgggtt gaaagtgggt gggagagttc gaggccttgc      960

gcttaaggag ccccttcgcc tcgtgcttga gttgaggcct ggcttgggcg ctggggccgc     1020

cgcgtgcgaa tctggtggca ccttcgcgcc tatctcgctg ctttcgataa gtctctagcc     1080

atttaaaatt tttgatgacc tgctgcgacg ctttttttct ggcaagatag tcttgtaaat     1140

gcgggccaag atctgcacac tggtatttcg gtttttgggg ccgcgggcgg cgacggggcc     1200

cgtgcgtccc agcgcacatg ttcggcgagg cggggcctgc gagcgcggcc accgagaatc     1260

ggacgggggt agtctcaagc tggccggcct gctctggtgc ctggcctcgc gccgccgtgt     1320

atcgccccgc cctgggcggc aaggctggcc cggtcggcac cagttgcgtg agcggaaaga     1380

tggccgcttc ccggccctgc tgcagggagc tcaaaatgga ggacgcggcg ctcgggagag     1440

cgggcgggtg agtcacccac acaaaggaaa agggcctttc cgtcctcagc cgtcgcttca     1500

tgtgactcca cggagtaccg ggcgccgtcc aggcacctcg attagttctc gagcttttgg     1560

agtacgtcgt ctttaggttg gggggagggg ttttatgcga tggagtttcc ccacactgag     1620

tgggtggaga ctgaagttag gccagcttgg cacttgatgt aattctcctt ggaatttgcc     1680

ctttttgagt ttggatcttg gttcattctc aagcctcaga cagtggttca aagttttttc     1740

cttccatttc aggtgtcgtg aaaactaccc ctaaaagcca aatctagagc caccatggac     1800

atgagagtgc cggcgcaact gctcggcctg ctgttgctgt ggctgagggg agccagatgc     1860

gacatccaga tgactcagtc accctcgagc cttagcgtgt ccctcggaga tcgcgccacc     1920

atcacctgtc gggcctccga atccgtggac tcctacggca cctccttcat gcactggtac     1980

cagcagaagc caggaaagcc tcccaagctg ttgatctatc tggcctcgaa tctggaatca     2040

ggagtgccgt cgcggttcag cggctccgga tcacgcactg acttcacgct gaccattagc     2100

cccgtgcaag cagaggactt tgcgacctac tactgccagc agaacaacga atacccttac     2160

actttcggcc agggtaccaa gctcgaaatc aagcggacag tggcagcccc atcggtgttc     2220

attttcccgc cgtcggatga gcagctcaag tccggtactg cctccgtggt ctgcctgctg     2280

aacaactttt accctcgcga agcgaaggtc caatggaaag tggataacgc cctccagtcc     2340

ggaaactccc aggagtctgt caccgagcag gactcaaagg acagcactta ctccctgtcc     2400

tcgactctga ccctgtcgaa ggcagattac gagaagcaca aagtgtacgc ctgcgaagtg     2460

acccatcaag gcctttccag cccggtcacc aagagcttca atcgggggga gtgttagtaa     2520

tgaggatccc cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac     2580

tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct     2640

ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct     2700

gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg     2760

ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag     2820

aaccagctgg ggctcgagcg gccgcccctt ctgaggcgga aagaaccagc tgtggaatgt     2880

gtgtcagtta gggtgtggaa agtccccagg ctccccagca ggcagaagta tgcaaagcat     2940

gcatctcaat tagtcagcaa ccaggtgtgg aaagtcccca ggctccccag caggcagaag     3000

tatgcaaagc atgcatctca attagtcagc aaccatagtc ccgcccctaa ctccgcccat     3060

cccgccccta actccgccca gttccgccca ttctccgccc catggctgac taattttttt     3120

tatttatgca gaggccgagg ccgcctcggc ctctgagcta ttccagaagt agtgaggagg     3180

cttttttgga ggcctaggct tttgcaaaaa agctagcttc ccgctgccat catggttcga     3240

ccattgaact gcatcgtcgc cgtgtcccaa aatatgggga ttggcaagaa cggagaccta     3300

ccctggcctc cgctcaggaa cgagttcaag tacttccaaa gaatgaccac aacctcttca     3360

gtggaaggta aacagaatct ggtgattatg ggtaggaaaa cctggttctc cattcctgag     3420

aagaatcgac ctttaaagga cagaattaat atagttctca gtagagaact caaagaacca     3480

ccacgaggag ctcattttct tgccaaaagt ttggatgatg ccttaagact tattgaacaa     3540

ccggaattgg caagtaaagt agacatggtt tggatagtcg gaggcagttc tgtttaccag     3600

gaagccatga atcaaccagg ccaccttaga ctctttgtga caaggatcat gcaggaattt     3660

gaaagtgaca cgtttttccc agaaattgat ttggggaaat ataaacttct cccagaatac     3720

ccaggcgtcc tctctgaggt ccaggaggaa aaaggcatca agtataagtt tgaagtctac     3780

gagaagaaag actaacagga agatgctttc aagttctctg ctcccctcct aaagctatgc     3840

atttttataa gaccatggga cttttgctgg ctttagatcc cgcggagatc cagacatgat     3900

aagatacatt gatgagtttg gacaaaccac aactagaatg cagtgaaaaa aatgctttat     3960

ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ataagctgca ataaacaagt     4020

taacaacaac aattgcattc attttatgtt tcaggttcag ggggaggtgt gggaggtttt     4080

ttaaagcaag taaaacctct acaaatgtgg tatggctgat tatgagctcc agcttttgtt     4140

ccctttagtg agggttaatt gcgcgcttgg cgtaatcatg gtcatagctg tttcctgtgt     4200

gaaattgtta tccgctcaca attccacaca acatacgagc cggaagcata aagtgtaaag     4260

cctggggtgc ctaatgagtg agctaactca cattaattgc gttgcgctca ctgcccgctt     4320

tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc gcggggagag     4380

gcggtttgcg tattgggcgc tcttccgctt cctcgctcac tgactcgctg cgctcggtcg     4440

ttcggctgcg gcgagcggta tcagctcact caaaggcggt aatacggtta tccacagaat     4500

caggggataa cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta     4560

aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa     4620

atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc     4680

cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctgt     4740

ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt aggtatctca     4800

gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg     4860

accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttat     4920

cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta ggcggtgcta     4980

cagagttctt gaagtggtgg cctaactacg gctacactag aaggacagta tttggtatct     5040

gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga tccggcaaac     5100

aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg cgcagaaaaa     5160

aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa     5220

actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc tagatccttt     5280

taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact tggtctgaca     5340

gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt cgttcatcca     5400

tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta ccatctggcc     5460

ccagtgctgc aatgataccg cgagacccac gctcaccggc tccagattta tcagcaataa     5520

accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc gcctccatcc     5580

agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat agtttgcgca     5640

acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat     5700

tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag     5760

cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca gtgttatcac     5820

tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta agatgctttt     5880

ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg cgaccgagtt     5940

gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact ttaaaagtgc     6000

tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg ctgttgagat     6060

ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt actttcacca     6120

gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga ataagggcga     6180

cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc atttatcagg     6240

gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa caaatagggg     6300

ttccgcgcac atttccccga aaagtgccac ctgggaaatt gtaaacgtta atattttgtt     6360

aaaattcgcg ttaaattttt gttaaatcag ctcatttttt aaccaatagg ccgaaatcgg     6420

caaaatccct tataaatcaa aagaatagac cgagataggg ttgagtgttg ttccagtttg     6480

gaacaagagt ccactattaa agaacgtgga ctccaacgtc aaagggcgaa aaaccgtcta     6540

tcagggcgat ggcccactac gtgaaccatc accctaatca agttttttgg ggtcgaggtg     6600

ccgtaaagca ctaaatcgga accctaaagg gagcccccga tttagagctt gacggggaaa     6660

gccggcgaac gtggcgagaa aggaagggaa gaaagcgaaa ggagcgggcg ctagggcgct     6720

ggcaagtgta gcggtcacgc tgcgcgtaac caccacaccc gccgcgctta atgcgccgct     6780

acagggcgcg tcccattcgc cattcaggct gcgcaactgt tgggaagggc gat            6833


<210>  27
<211>  6833
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid encoding the Light Chain of a melanin Humanized Antibody 
       (8C3-HE-VK1B-hKappa)

<400>  27
cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg gggatgtgct gcaaggcgat       60

taagttgggt aacgccaggg ttttcccagt cacgacgttg taaaacgacg gccagtgagc      120

gcgcgtaata cgactcacta tagggcgaat tgggtaccgg gccccccctc gaggtcgacg      180

gtatcgataa gcttgatatc gaattcgctg ggctgagacc cgcagaggaa gacgctctag      240

ggatttgtcc cggactagcg agatggcaag gctgaggacg ggaggctgat tgagaggcga      300

aggtacaccc taatctcaat acaacccttg gagctaagcc agcaatggta gagggaagat      360

tctgcacgtc ccttccaggc ggcctccccg tcaccaccca ccccaacccg ccccgaccgg      420

agctgagagt aattcataca aaaggactcg cccctgcctt ggggaatccc agggaccgtc      480

gttaaactcc cactaacgta gaacccagag atcgctgcgt tcccgccccc tcacccgccc      540

gctctcgtca tcactgaggt ggagaagagc atgcgtgagg ctccggtgcc cgtcagtggg      600

cagagcgcac atcgcccaca gtccccgaga agttgggggg aggggtcggc aattgaaccg      660

gtgcctagag aaggtggcgc ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc      720

tttttcccga gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt      780

ttcgcaacgg gtttgccgcc agaacacagg taagtgccgt gtgtggttcc cgcgggcctg      840

gcctctttac gggttatggc ccttgcgtgc cttgaattac ttccacgccc ctggctgcag      900

tacgtgattc ttgatcccga gcttcgggtt gaaagtgggt gggagagttc gaggccttgc      960

gcttaaggag ccccttcgcc tcgtgcttga gttgaggcct ggcttgggcg ctggggccgc     1020

cgcgtgcgaa tctggtggca ccttcgcgcc tatctcgctg ctttcgataa gtctctagcc     1080

atttaaaatt tttgatgacc tgctgcgacg ctttttttct ggcaagatag tcttgtaaat     1140

gcgggccaag atctgcacac tggtatttcg gtttttgggg ccgcgggcgg cgacggggcc     1200

cgtgcgtccc agcgcacatg ttcggcgagg cggggcctgc gagcgcggcc accgagaatc     1260

ggacgggggt agtctcaagc tggccggcct gctctggtgc ctggcctcgc gccgccgtgt     1320

atcgccccgc cctgggcggc aaggctggcc cggtcggcac cagttgcgtg agcggaaaga     1380

tggccgcttc ccggccctgc tgcagggagc tcaaaatgga ggacgcggcg ctcgggagag     1440

cgggcgggtg agtcacccac acaaaggaaa agggcctttc cgtcctcagc cgtcgcttca     1500

tgtgactcca cggagtaccg ggcgccgtcc aggcacctcg attagttctc gagcttttgg     1560

agtacgtcgt ctttaggttg gggggagggg ttttatgcga tggagtttcc ccacactgag     1620

tgggtggaga ctgaagttag gccagcttgg cacttgatgt aattctcctt ggaatttgcc     1680

ctttttgagt ttggatcttg gttcattctc aagcctcaga cagtggttca aagttttttc     1740

cttccatttc aggtgtcgtg aaaactaccc ctaaaagcca aatctagagc caccatggac     1800

atgagagtgc cggcgcaact gctcggcctg ctgttgctgt ggctgagggg agccagatgc     1860

gacatccaga tgactcagtc accctcgagc cttagcgtgt ccgtgggaga tcgcgccacc     1920

atcacctgtc gggcctccga atccgtggac tcctacggca cctccttcat gcactggtac     1980

cagcagaagc caggaaagcc tcccaagctg ttgatctatc tggcctcgaa tctgcagtca     2040

ggagtgccgt cgcggttcag cggctccgga tcacgcactg acttcacgct gaccattagc     2100

cccgtgcaag cagaggactt tgcgacctac tactgccagc agaacaacga atacccttac     2160

actttcggcc agggtaccaa gctcgaaatc aagcggacag tggcagcccc atcggtgttc     2220

attttcccgc cgtcggatga gcagctcaag tccggtactg cctccgtggt ctgcctgctg     2280

aacaactttt accctcgcga agcgaaggtc caatggaaag tggataacgc cctccagtcc     2340

ggaaactccc aggagtctgt caccgagcag gactcaaagg acagcactta ctccctgtcc     2400

tcgactctga ccctgtcgaa ggcagattac gagaagcaca aagtgtacgc ctgcgaagtg     2460

acccatcaag gcctttccag cccggtcacc aagagcttca atcgggggga gtgttagtaa     2520

tgaggatccc cctattctat agtgtcacct aaatgctaga gctcgctgat cagcctcgac     2580

tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct     2640

ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct     2700

gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg     2760

ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag     2820

aaccagctgg ggctcgagcg gccgcccctt ctgaggcgga aagaaccagc tgtggaatgt     2880

gtgtcagtta gggtgtggaa agtccccagg ctccccagca ggcagaagta tgcaaagcat     2940

gcatctcaat tagtcagcaa ccaggtgtgg aaagtcccca ggctccccag caggcagaag     3000

tatgcaaagc atgcatctca attagtcagc aaccatagtc ccgcccctaa ctccgcccat     3060

cccgccccta actccgccca gttccgccca ttctccgccc catggctgac taattttttt     3120

tatttatgca gaggccgagg ccgcctcggc ctctgagcta ttccagaagt agtgaggagg     3180

cttttttgga ggcctaggct tttgcaaaaa agctagcttc ccgctgccat catggttcga     3240

ccattgaact gcatcgtcgc cgtgtcccaa aatatgggga ttggcaagaa cggagaccta     3300

ccctggcctc cgctcaggaa cgagttcaag tacttccaaa gaatgaccac aacctcttca     3360

gtggaaggta aacagaatct ggtgattatg ggtaggaaaa cctggttctc cattcctgag     3420

aagaatcgac ctttaaagga cagaattaat atagttctca gtagagaact caaagaacca     3480

ccacgaggag ctcattttct tgccaaaagt ttggatgatg ccttaagact tattgaacaa     3540

ccggaattgg caagtaaagt agacatggtt tggatagtcg gaggcagttc tgtttaccag     3600

gaagccatga atcaaccagg ccaccttaga ctctttgtga caaggatcat gcaggaattt     3660

gaaagtgaca cgtttttccc agaaattgat ttggggaaat ataaacttct cccagaatac     3720

ccaggcgtcc tctctgaggt ccaggaggaa aaaggcatca agtataagtt tgaagtctac     3780

gagaagaaag actaacagga agatgctttc aagttctctg ctcccctcct aaagctatgc     3840

atttttataa gaccatggga cttttgctgg ctttagatcc cgcggagatc cagacatgat     3900

aagatacatt gatgagtttg gacaaaccac aactagaatg cagtgaaaaa aatgctttat     3960

ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ataagctgca ataaacaagt     4020

taacaacaac aattgcattc attttatgtt tcaggttcag ggggaggtgt gggaggtttt     4080

ttaaagcaag taaaacctct acaaatgtgg tatggctgat tatgagctcc agcttttgtt     4140

ccctttagtg agggttaatt gcgcgcttgg cgtaatcatg gtcatagctg tttcctgtgt     4200

gaaattgtta tccgctcaca attccacaca acatacgagc cggaagcata aagtgtaaag     4260

cctggggtgc ctaatgagtg agctaactca cattaattgc gttgcgctca ctgcccgctt     4320

tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc gcggggagag     4380

gcggtttgcg tattgggcgc tcttccgctt cctcgctcac tgactcgctg cgctcggtcg     4440

ttcggctgcg gcgagcggta tcagctcact caaaggcggt aatacggtta tccacagaat     4500

caggggataa cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta     4560

aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa     4620

atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc     4680

cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctgt     4740

ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt aggtatctca     4800

gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg     4860

accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttat     4920

cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta ggcggtgcta     4980

cagagttctt gaagtggtgg cctaactacg gctacactag aaggacagta tttggtatct     5040

gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga tccggcaaac     5100

aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg cgcagaaaaa     5160

aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa     5220

actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc tagatccttt     5280

taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact tggtctgaca     5340

gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt cgttcatcca     5400

tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta ccatctggcc     5460

ccagtgctgc aatgataccg cgagacccac gctcaccggc tccagattta tcagcaataa     5520

accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc gcctccatcc     5580

agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat agtttgcgca     5640

acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat     5700

tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag     5760

cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca gtgttatcac     5820

tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta agatgctttt     5880

ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg cgaccgagtt     5940

gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact ttaaaagtgc     6000

tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg ctgttgagat     6060

ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt actttcacca     6120

gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga ataagggcga     6180

cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc atttatcagg     6240

gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa caaatagggg     6300

ttccgcgcac atttccccga aaagtgccac ctgggaaatt gtaaacgtta atattttgtt     6360

aaaattcgcg ttaaattttt gttaaatcag ctcatttttt aaccaatagg ccgaaatcgg     6420

caaaatccct tataaatcaa aagaatagac cgagataggg ttgagtgttg ttccagtttg     6480

gaacaagagt ccactattaa agaacgtgga ctccaacgtc aaagggcgaa aaaccgtcta     6540

tcagggcgat ggcccactac gtgaaccatc accctaatca agttttttgg ggtcgaggtg     6600

ccgtaaagca ctaaatcgga accctaaagg gagcccccga tttagagctt gacggggaaa     6660

gccggcgaac gtggcgagaa aggaagggaa gaaagcgaaa ggagcgggcg ctagggcgct     6720

ggcaagtgta gcggtcacgc tgcgcgtaac caccacaccc gccgcgctta atgcgccgct     6780

acagggcgcg tcccattcgc cattcaggct gcgcaactgt tgggaagggc gat            6833


<210>  28
<211>  7679
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid encoding the Heavy Chain of a melanin Humanized Antibody 
       (8C3-HE-VH3A-hIgG1)

<400>  28
cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg gggatgtgct gcaaggcgat       60

taagttgggt aacgccaggg ttttcccagt cacgacgttg taaaacgacg gccagtgagc      120

gcgcgtaata cgactcacta tagggcgaat tgggtaccgg gccccccctc gaggtcgacg      180

gtatcgataa gcttgatatc gaattcgctg ggctgagacc cgcagaggaa gacgctctag      240

ggatttgtcc cggactagcg agatggcaag gctgaggacg ggaggctgat tgagaggcga      300

aggtacaccc taatctcaat acaacccttg gagctaagcc agcaatggta gagggaagat      360

tctgcacgtc ccttccaggc ggcctccccg tcaccaccca ccccaacccg ccccgaccgg      420

agctgagagt aattcataca aaaggactcg cccctgcctt ggggaatccc agggaccgtc      480

gttaaactcc cactaacgta gaacccagag atcgctgcgt tcccgccccc tcacccgccc      540

gctctcgtca tcactgaggt ggagaagagc atgcgtgagg ctccggtgcc cgtcagtggg      600

cagagcgcac atcgcccaca gtccccgaga agttgggggg aggggtcggc aattgaaccg      660

gtgcctagag aaggtggcgc ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc      720

tttttcccga gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt      780

ttcgcaacgg gtttgccgcc agaacacagg taagtgccgt gtgtggttcc cgcgggcctg      840

gcctctttac gggttatggc ccttgcgtgc cttgaattac ttccacgccc ctggctgcag      900

tacgtgattc ttgatcccga gcttcgggtt gaaagtgggt gggagagttc gaggccttgc      960

gcttaaggag ccccttcgcc tcgtgcttga gttgaggcct ggcttgggcg ctggggccgc     1020

cgcgtgcgaa tctggtggca ccttcgcgcc tatctcgctg ctttcgataa gtctctagcc     1080

atttaaaatt tttgatgacc tgctgcgacg ctttttttct ggcaagatag tcttgtaaat     1140

gcgggccaag atctgcacac tggtatttcg gtttttgggg ccgcgggcgg cgacggggcc     1200

cgtgcgtccc agcgcacatg ttcggcgagg cggggcctgc gagcgcggcc accgagaatc     1260

ggacgggggt agtctcaagc tggccggcct gctctggtgc ctggcctcgc gccgccgtgt     1320

atcgccccgc cctgggcggc aaggctggcc cggtcggcac cagttgcgtg agcggaaaga     1380

tggccgcttc ccggccctgc tgcagggagc tcaaaatgga ggacgcggcg ctcgggagag     1440

cgggcgggtg agtcacccac acaaaggaaa agggcctttc cgtcctcagc cgtcgcttca     1500

tgtgactcca cggagtaccg ggcgccgtcc aggcacctcg attagttctc gagcttttgg     1560

agtacgtcgt ctttaggttg gggggagggg ttttatgcga tggagtttcc ccacactgag     1620

tgggtggaga ctgaagttag gccagcttgg cacttgatgt aattctcctt ggaatttgcc     1680

ctttttgagt ttggatcttg gttcattctc aagcctcaga cagtggttca aagttttttc     1740

cttccatttc aggtgtcgtg aaaactaccc ctaaaagcca aatctagagc caccatggac     1800

atgcgcgtgc cggcacaact gctgggcctg ctgctgcttt ggctgcgggg agctagatgc     1860

gaagtgcagc tcgtcgaatc cggaggagga ctggtgcagc ctggcggaag catgcgcgtg     1920

tcatgcgcgg cttccggatt caccttctcg gacgcctgga tggattgggt cagacaagcg     1980

cccggcaaag gcctggaatg ggtggccgag attcggtcca aggcccataa ccacgccacc     2040

tactacgccg agtccgtgaa ggggcgcttt actatctccc gggatgactc gaagtcgacg     2100

gtgtacctcc agatgaactc attgagggcc gaggacactg ggacctacta ctgtacccgc     2160

ggaggctact acgggaacta tggtttcttc gcctactggg gccagggtac cctcgtgact     2220

gtcagcagcg ccagcaccaa gggccccagc gtgttcccac tggccccaag ctccaagtca     2280

acctccggcg gaactgctgc gctgggctgc ttggtgaagg actacttccc cgaaccggtc     2340

accgtgtcct ggaacagcgg agccctgacc tcgggagtcc acactttccc cgctgtgctg     2400

cagtcgtccg gcctgtactc gctctcgtcc gtggtcactg tcccgtcctc gtccctgggt     2460

actcagacct acatttgcaa cgtcaaccac aagccttcaa acacgaaagt ggacaagaag     2520

gtcgagccga agtcctgcga caaaacccat acttgccctc cttgtccggc tcccgaactg     2580

ctgggcggac cttccgtgtt cctcttcccg cctaagccga aagacaccct gatgatcagc     2640

aggactccgg aagtgacatg cgtggtggtg gacgtgtcgc acgaggaccc ggaggtcaag     2700

tttaattggt acgtggacgg agtggaagtc cacaacgcca agaccaagcc acgggaagaa     2760

cagtacaatt ccacctatcg cgtggtgtcc gtgcttaccg tgcttcacca agactggctg     2820

aacggaaagg agtacaagtg caaagtgtca aacaaagccc tgcctgcccc aatcgaaaag     2880

accatcagca aggccaaggg gcagcctcgg gaaccccaag tgtacactct cccgccgtca     2940

agagatgaac tgaccaagaa ccaagtgtcc ctcacttgtc tcgtgaaggg attctacccc     3000

tccgatatcg ccgtggagtg ggaatccaac gggcaacccg agaacaacta caagaccacc     3060

cctccggtgc ttgattccga tggctccttc ttcctctact ccaagctgac cgtggacaag     3120

tcaagatggc agcaggggaa cgtgttctcc tgctccgtca tgcacgaggc cctgcacaac     3180

cattacaccc agaagtctct gtcgctgagc ccgggaaaat aatgaggatc cccctattct     3240

atagtgtcac ctaaatgcta gagctcgctg atcagcctcg actgtgcctt ctagttgcca     3300

gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac     3360

tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat     3420

tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca     3480

tgctggggat gcggtgggct ctatggcttc tgaggcggaa agaaccagct ggggctcgag     3540

cggccgcaga ttgtaccttc tgaggcggaa agaaccagct gtggaatgtg tgtcagttag     3600

ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg catctcaatt     3660

agtcagcaac caggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca     3720

tgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc ccgcccctaa     3780

ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt atttatgcag     3840

aggccgaggc cgcctcggcc tctgagctat tccagaagta gtgaggaggc ttttttggag     3900

gcctaggctt ttgcaaaaag cttaccatga ttgaacaaga tggattgcac gcaggttctc     3960

cggccgcttg ggtggagagg ctattcggct atgactgggc acaacagaca atcggctgct     4020

ctgatgccgc cgtgttccgg ctgtcagcgc aggggcgccc ggttcttttt gtcaagaccg     4080

acctgtccgg tgccctgaat gaactgcagg acgaggcagc gcggctatcg tggctggcca     4140

cgacgggcgt tccttgcgca gctgtgctcg acgttgtcac tgaagcggga agggactggc     4200

tgctattggg cgaagtgccg gggcaggatc tcctgtcatc tcaccttgct cctgccgaga     4260

aagtatccat catggctgat gcaatgcggc ggctgcatac gcttgatccg gctacctgcc     4320

cattcgacca ccaagcgaaa catcgcatcg agcgagcacg tactcggatg gaagccggtc     4380

ttgtcgatca ggatgatctg gacgaagagc atcaggggct cgcgccagcc gaactgttcg     4440

ccaggctcaa ggcgcgcatg cccgacggcg aggatctcgt cgtgacccat ggcgatgcct     4500

gcttgccgaa tatcatggtg gaaaatggcc gcttttctgg attcatcgac tgtggccggc     4560

tgggtgtggc ggaccgctat caggacatag cgttggctac ccgtgatatt gctgaagagc     4620

ttggcggcga atgggctgac cgcttcctcg tgctttacgg tatcgccgct cccgattcgc     4680

agcgcatcgc cttctatcgc cttcttgacg agttcttctg agggatcgcg gagatccaga     4740

catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg     4800

ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa     4860

acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga     4920

ggttttttaa agcaagtaaa acctctacaa atgtggtatg gctgattatg agctccagct     4980

tttgttccct ttagtgaggg ttaattgcgc gcttggcgta atcatggtca tagctgtttc     5040

ctgtgtgaaa ttgttatccg ctcacaattc cacacaacat acgagccgga agcataaagt     5100

gtaaagcctg gggtgcctaa tgagtgagct aactcacatt aattgcgttg cgctcactgc     5160

ccgctttcca gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg     5220

ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc gctcactgac tcgctgcgct     5280

cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca     5340

cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga     5400

accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc     5460

acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg     5520

cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat     5580

acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt     5640

atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc     5700

agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg     5760

acttatcgcc actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg     5820

gtgctacaga gttcttgaag tggtggccta actacggcta cactagaagg acagtatttg     5880

gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg     5940

gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca     6000

gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga     6060

acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga     6120

tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt     6180

ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt     6240

catccatagt tgcctgactc cccgtcgtgt agataactac gatacgggag ggcttaccat     6300

ctggccccag tgctgcaatg ataccgcgag acccacgctc accggctcca gatttatcag     6360

caataaacca gccagccgga agggccgagc gcagaagtgg tcctgcaact ttatccgcct     6420

ccatccagtc tattaattgt tgccgggaag ctagagtaag tagttcgcca gttaatagtt     6480

tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg     6540

cttcattcag ctccggttcc caacgatcaa ggcgagttac atgatccccc atgttgtgca     6600

aaaaagcggt tagctccttc ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt     6660

tatcactcat ggttatggca gcactgcata attctcttac tgtcatgcca tccgtaagat     6720

gcttttctgt gactggtgag tactcaacca agtcattctg agaatagtgt atgcggcgac     6780

cgagttgctc ttgcccggcg tcaatacggg ataataccgc gccacatagc agaactttaa     6840

aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt     6900

tgagatccag ttcgatgtaa cccactcgtg cacccaactg atcttcagca tcttttactt     6960

tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa     7020

gggcgacacg gaaatgttga atactcatac tcttcctttt tcaatattat tgaagcattt     7080

atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa aataaacaaa     7140

taggggttcc gcgcacattt ccccgaaaag tgccacctgg gaaattgtaa acgttaatat     7200

tttgttaaaa ttcgcgttaa atttttgtta aatcagctca ttttttaacc aataggccga     7260

aatcggcaaa atcccttata aatcaaaaga atagaccgag atagggttga gtgttgttcc     7320

agtttggaac aagagtccac tattaaagaa cgtggactcc aacgtcaaag ggcgaaaaac     7380

cgtctatcag ggcgatggcc cactacgtga accatcaccc taatcaagtt ttttggggtc     7440

gaggtgccgt aaagcactaa atcggaaccc taaagggagc ccccgattta gagcttgacg     7500

gggaaagccg gcgaacgtgg cgagaaagga agggaagaaa gcgaaaggag cgggcgctag     7560

ggcgctggca agtgtagcgg tcacgctgcg cgtaaccacc acacccgccg cgcttaatgc     7620

gccgctacag ggcgcgtccc attcgccatt caggctgcgc aactgttggg aagggcgat      7679


<210>  29
<211>  7679
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid encoding the Heavy Chain of a melanin Humanized Antibody 
       (8C3-HE-VH3B-hIgG1)

<400>  29
cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg gggatgtgct gcaaggcgat       60

taagttgggt aacgccaggg ttttcccagt cacgacgttg taaaacgacg gccagtgagc      120

gcgcgtaata cgactcacta tagggcgaat tgggtaccgg gccccccctc gaggtcgacg      180

gtatcgataa gcttgatatc gaattcgctg ggctgagacc cgcagaggaa gacgctctag      240

ggatttgtcc cggactagcg agatggcaag gctgaggacg ggaggctgat tgagaggcga      300

aggtacaccc taatctcaat acaacccttg gagctaagcc agcaatggta gagggaagat      360

tctgcacgtc ccttccaggc ggcctccccg tcaccaccca ccccaacccg ccccgaccgg      420

agctgagagt aattcataca aaaggactcg cccctgcctt ggggaatccc agggaccgtc      480

gttaaactcc cactaacgta gaacccagag atcgctgcgt tcccgccccc tcacccgccc      540

gctctcgtca tcactgaggt ggagaagagc atgcgtgagg ctccggtgcc cgtcagtggg      600

cagagcgcac atcgcccaca gtccccgaga agttgggggg aggggtcggc aattgaaccg      660

gtgcctagag aaggtggcgc ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc      720

tttttcccga gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt      780

ttcgcaacgg gtttgccgcc agaacacagg taagtgccgt gtgtggttcc cgcgggcctg      840

gcctctttac gggttatggc ccttgcgtgc cttgaattac ttccacgccc ctggctgcag      900

tacgtgattc ttgatcccga gcttcgggtt gaaagtgggt gggagagttc gaggccttgc      960

gcttaaggag ccccttcgcc tcgtgcttga gttgaggcct ggcttgggcg ctggggccgc     1020

cgcgtgcgaa tctggtggca ccttcgcgcc tatctcgctg ctttcgataa gtctctagcc     1080

atttaaaatt tttgatgacc tgctgcgacg ctttttttct ggcaagatag tcttgtaaat     1140

gcgggccaag atctgcacac tggtatttcg gtttttgggg ccgcgggcgg cgacggggcc     1200

cgtgcgtccc agcgcacatg ttcggcgagg cggggcctgc gagcgcggcc accgagaatc     1260

ggacgggggt agtctcaagc tggccggcct gctctggtgc ctggcctcgc gccgccgtgt     1320

atcgccccgc cctgggcggc aaggctggcc cggtcggcac cagttgcgtg agcggaaaga     1380

tggccgcttc ccggccctgc tgcagggagc tcaaaatgga ggacgcggcg ctcgggagag     1440

cgggcgggtg agtcacccac acaaaggaaa agggcctttc cgtcctcagc cgtcgcttca     1500

tgtgactcca cggagtaccg ggcgccgtcc aggcacctcg attagttctc gagcttttgg     1560

agtacgtcgt ctttaggttg gggggagggg ttttatgcga tggagtttcc ccacactgag     1620

tgggtggaga ctgaagttag gccagcttgg cacttgatgt aattctcctt ggaatttgcc     1680

ctttttgagt ttggatcttg gttcattctc aagcctcaga cagtggttca aagttttttc     1740

cttccatttc aggtgtcgtg aaaactaccc ctaaaagcca aatctagagc caccatggac     1800

atgcgcgtgc cggcacaact gctgggcctg ctgctgcttt ggctgcgggg agctagatgc     1860

gaagtgcagc tcgtggaatc cggaggagga ctggtgcagc ctggcggaag catgcgcgtg     1920

tcatgcgcgg cttccggatt caccttctcg gacgcctgga tggattgggt cagacaagcg     1980

cccggcaaag gcctggaatg ggtggccgag attcggtcca aggcccataa ccacgccacc     2040

tactacgccg actccgtgaa ggggcgcttt actatctccc gggataactc gaagaatacc     2100

gtgtacctcc agatgaactc attgagggcc gaggacactg gggtctacta ctgtacccgc     2160

ggaggctact acgggaacta tggtttcttc gcctactggg gccagggtac cctcgtgact     2220

gtcagcagcg ccagcaccaa gggccccagc gtgttcccac tggccccaag ctccaagtca     2280

acctccggcg gaactgctgc gctgggctgc ttggtgaagg actacttccc cgaaccggtc     2340

accgtgtcct ggaacagcgg agccctgacc tcgggagtcc acactttccc cgctgtgctg     2400

cagtcgtccg gcctgtactc gctctcgtcc gtggtcactg tcccgtcctc gtccctgggt     2460

actcagacct acatttgcaa cgtcaaccac aagccttcaa acacgaaagt ggacaagaag     2520

gtcgagccga agtcctgcga caaaacccat acttgccctc cttgtccggc tcccgaactg     2580

ctgggcggac cttccgtgtt cctcttcccg cctaagccga aagacaccct gatgatcagc     2640

aggactccgg aagtgacatg cgtggtggtg gacgtgtcgc acgaggaccc ggaggtcaag     2700

tttaattggt acgtggacgg agtggaagtc cacaacgcca agaccaagcc acgggaagaa     2760

cagtacaatt ccacctatcg cgtggtgtcc gtgcttaccg tgcttcacca agactggctg     2820

aacggaaagg agtacaagtg caaagtgtca aacaaagccc tgcctgcccc aatcgaaaag     2880

accatcagca aggccaaggg gcagcctcgg gaaccccaag tgtacactct cccgccgtca     2940

agagatgaac tgaccaagaa ccaagtgtcc ctcacttgtc tcgtgaaggg attctacccc     3000

tccgatatcg ccgtggagtg ggaatccaac gggcaacccg agaacaacta caagaccacc     3060

cctccggtgc ttgattccga tggctccttc ttcctctact ccaagctgac cgtggacaag     3120

tcaagatggc agcaggggaa cgtgttctcc tgctccgtca tgcacgaggc cctgcacaac     3180

cattacaccc agaagtctct gtcgctgagc ccgggaaaat aatgaggatc cccctattct     3240

atagtgtcac ctaaatgcta gagctcgctg atcagcctcg actgtgcctt ctagttgcca     3300

gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac     3360

tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat     3420

tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca     3480

tgctggggat gcggtgggct ctatggcttc tgaggcggaa agaaccagct ggggctcgag     3540

cggccgcaga ttgtaccttc tgaggcggaa agaaccagct gtggaatgtg tgtcagttag     3600

ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg catctcaatt     3660

agtcagcaac caggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca     3720

tgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc ccgcccctaa     3780

ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt atttatgcag     3840

aggccgaggc cgcctcggcc tctgagctat tccagaagta gtgaggaggc ttttttggag     3900

gcctaggctt ttgcaaaaag cttaccatga ttgaacaaga tggattgcac gcaggttctc     3960

cggccgcttg ggtggagagg ctattcggct atgactgggc acaacagaca atcggctgct     4020

ctgatgccgc cgtgttccgg ctgtcagcgc aggggcgccc ggttcttttt gtcaagaccg     4080

acctgtccgg tgccctgaat gaactgcagg acgaggcagc gcggctatcg tggctggcca     4140

cgacgggcgt tccttgcgca gctgtgctcg acgttgtcac tgaagcggga agggactggc     4200

tgctattggg cgaagtgccg gggcaggatc tcctgtcatc tcaccttgct cctgccgaga     4260

aagtatccat catggctgat gcaatgcggc ggctgcatac gcttgatccg gctacctgcc     4320

cattcgacca ccaagcgaaa catcgcatcg agcgagcacg tactcggatg gaagccggtc     4380

ttgtcgatca ggatgatctg gacgaagagc atcaggggct cgcgccagcc gaactgttcg     4440

ccaggctcaa ggcgcgcatg cccgacggcg aggatctcgt cgtgacccat ggcgatgcct     4500

gcttgccgaa tatcatggtg gaaaatggcc gcttttctgg attcatcgac tgtggccggc     4560

tgggtgtggc ggaccgctat caggacatag cgttggctac ccgtgatatt gctgaagagc     4620

ttggcggcga atgggctgac cgcttcctcg tgctttacgg tatcgccgct cccgattcgc     4680

agcgcatcgc cttctatcgc cttcttgacg agttcttctg agggatcgcg gagatccaga     4740

catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg     4800

ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa     4860

acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga     4920

ggttttttaa agcaagtaaa acctctacaa atgtggtatg gctgattatg agctccagct     4980

tttgttccct ttagtgaggg ttaattgcgc gcttggcgta atcatggtca tagctgtttc     5040

ctgtgtgaaa ttgttatccg ctcacaattc cacacaacat acgagccgga agcataaagt     5100

gtaaagcctg gggtgcctaa tgagtgagct aactcacatt aattgcgttg cgctcactgc     5160

ccgctttcca gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg     5220

ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc gctcactgac tcgctgcgct     5280

cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca     5340

cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga     5400

accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc     5460

acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg     5520

cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat     5580

acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt     5640

atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc     5700

agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg     5760

acttatcgcc actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg     5820

gtgctacaga gttcttgaag tggtggccta actacggcta cactagaagg acagtatttg     5880

gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg     5940

gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca     6000

gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga     6060

acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga     6120

tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt     6180

ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt     6240

catccatagt tgcctgactc cccgtcgtgt agataactac gatacgggag ggcttaccat     6300

ctggccccag tgctgcaatg ataccgcgag acccacgctc accggctcca gatttatcag     6360

caataaacca gccagccgga agggccgagc gcagaagtgg tcctgcaact ttatccgcct     6420

ccatccagtc tattaattgt tgccgggaag ctagagtaag tagttcgcca gttaatagtt     6480

tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg     6540

cttcattcag ctccggttcc caacgatcaa ggcgagttac atgatccccc atgttgtgca     6600

aaaaagcggt tagctccttc ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt     6660

tatcactcat ggttatggca gcactgcata attctcttac tgtcatgcca tccgtaagat     6720

gcttttctgt gactggtgag tactcaacca agtcattctg agaatagtgt atgcggcgac     6780

cgagttgctc ttgcccggcg tcaatacggg ataataccgc gccacatagc agaactttaa     6840

aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt     6900

tgagatccag ttcgatgtaa cccactcgtg cacccaactg atcttcagca tcttttactt     6960

tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa     7020

gggcgacacg gaaatgttga atactcatac tcttcctttt tcaatattat tgaagcattt     7080

atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa aataaacaaa     7140

taggggttcc gcgcacattt ccccgaaaag tgccacctgg gaaattgtaa acgttaatat     7200

tttgttaaaa ttcgcgttaa atttttgtta aatcagctca ttttttaacc aataggccga     7260

aatcggcaaa atcccttata aatcaaaaga atagaccgag atagggttga gtgttgttcc     7320

agtttggaac aagagtccac tattaaagaa cgtggactcc aacgtcaaag ggcgaaaaac     7380

cgtctatcag ggcgatggcc cactacgtga accatcaccc taatcaagtt ttttggggtc     7440

gaggtgccgt aaagcactaa atcggaaccc taaagggagc ccccgattta gagcttgacg     7500

gggaaagccg gcgaacgtgg cgagaaagga agggaagaaa gcgaaaggag cgggcgctag     7560

ggcgctggca agtgtagcgg tcacgctgcg cgtaaccacc acacccgccg cgcttaatgc     7620

gccgctacag ggcgcgtccc attcgccatt caggctgcgc aactgttggg aagggcgat      7679


<210>  30
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8C3-hIgG1 Chimera heavy chain

<400>  30

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Glu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Met Lys Val Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Asp Ala Trp Met Asp Trp Val Arg Gln Ser Pro Glu 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Glu Ile Arg Ser Lys Ala His Asn His 
65                  70                  75                  80  


Ala Thr Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asp Ser Lys Ser Ser Val Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Gly Thr Tyr Tyr Cys Thr Arg Gly Gly Tyr Tyr Gly Asn 
        115                 120                 125             


Tyr Gly Phe Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475 


<210>  31
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8C3-HE-VH3A-hIgG1 heavy chain

<400>  31

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Met Arg Val Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Asp Ala Trp Met Asp Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Glu Ile Arg Ser Lys Ala His Asn His 
65                  70                  75                  80  


Ala Thr Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asp Ser Lys Ser Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Gly Thr Tyr Tyr Cys Thr Arg Gly Gly Tyr Tyr Gly Asn 
        115                 120                 125             


Tyr Gly Phe Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475 


<210>  32
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8C3-HE-VH3B-hIgG1 heavy chain

<400>  32

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Met Arg Val Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Asp Ala Trp Met Asp Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Glu Ile Arg Ser Lys Ala His Asn His 
65                  70                  75                  80  


Ala Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Gly Val Tyr Tyr Cys Thr Arg Gly Gly Tyr Tyr Gly Asn 
        115                 120                 125             


Tyr Gly Phe Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475 


<210>  33
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Alignment Consensus

<400>  33

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Met Arg Val Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Asp Ala Trp Met Asp Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Glu Ile Arg Ser Lys Ala His Asn His 
65                  70                  75                  80  


Ala Thr Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asp Ser Lys Ser Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Gly Thr Tyr Tyr Cys Thr Arg Gly Gly Tyr Tyr Gly Asn 
        115                 120                 125             


Tyr Gly Phe Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475 


<210>  34
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8C3-HE-VK1A-hKappa light chain

<400>  34

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Val Ser Leu Gly Asp Arg Ala Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Glu Ser Val Asp Ser Tyr Gly Thr Ser Phe Met His Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu 
65                  70                  75                  80  


Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Pro Val Gln Ala Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Asn Asn Glu Tyr Pro Tyr Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  35
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8C3-HE-VK1B-hKappa light chain

<400>  35

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Val Ser Val Gly Asp Arg Ala Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Glu Ser Val Asp Ser Tyr Gly Thr Ser Phe Met His Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu 
65                  70                  75                  80  


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Pro Val Gln Ala Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Asn Asn Glu Tyr Pro Tyr Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  36
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8C3-HE-VK4-hKappa light chain

<400>  36

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Val Met Thr Gln Ser Pro Asp Ser 
            20                  25                  30          


Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser 
        35                  40                  45              


Glu Ser Val Asp Ser Tyr Gly Thr Ser Phe Met His Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Pro Val Gln Ala Glu Asp Val Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Asn Asn Glu Tyr Pro Tyr Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  37
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8C3-hKappa Chimera light chain

<400>  37

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Leu Met Thr Gln Ser Pro Ala Ser 
            20                  25                  30          


Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Glu Ser Val Asp Ser Tyr Gly Thr Ser Phe Met His Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu 
65                  70                  75                  80  


Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Asp Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Asn Asn Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  38
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain Alignment Consensus

<400>  38

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ala Val Ser Leu Gly Asp Arg Ala Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Glu Ser Val Asp Ser Tyr Gly Thr Ser Phe Met His Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu 
65                  70                  75                  80  


Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Pro Val Gln Ala Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Asn Asn Glu Tyr Pro Tyr Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


