                         SEQUENCE LISTING

<110>  ARROWHEAD PHARMACEUTICALS, INC.

<120>  RNAi Agents And Compositions For Inhibiting Expression Of 
Angiopoietin-Like 3 (ANGPTL3), And Methods Of Use 

<130>  30658-WO1

<150>  62/694,976
<151>  2018-07-07

<150>  62/651,284
<151>  2018-04-02

<150>  62/583,919
<151>  2017-11-09

<150>  62/558,819
<151>  2017-09-14

<160>  450

<210>  1
<211>  2951
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homo Sapiens angiopoietin-like 3 (ANGPTL3) transcript,
GenBank NM_014495.3

<400>  1
atatatagag ttaagaagtc taggtctgct tccagaagaa aacagttcca cgttgcttga    60

aattgaaaat caagataaaa atgttcacaa ttaagctcct tctttttatt gttcctctag    120

ttatttcctc cagaattgat caagacaatt catcatttga ttctctatct ccagagccaa    180

aatcaagatt tgctatgtta gacgatgtaa aaattttagc caatggcctc cttcagttgg    240

gacatggtct taaagacttt gtccataaga cgaagggcca aattaatgac atatttcaaa    300

aactcaacat atttgatcag tctttttatg atctatcgct gcaaaccagt gaaatcaaag    360

aagaagaaaa ggaactgaga agaactacat ataaactaca agtcaaaaat gaagaggtaa    420

agaatatgtc acttgaactc aactcaaaac ttgaaagcct cctagaagaa aaaattctac    480

ttcaacaaaa agtgaaatat ttagaagagc aactaactaa cttaattcaa aatcaacctg    540

aaactccaga acacccagaa gtaacttcac ttaaaacttt tgtagaaaaa caagataata    600

gcatcaaaga ccttctccag accgtggaag accaatataa acaattaaac caacagcata    660

gtcaaataaa agaaatagaa aatcagctca gaaggactag tattcaagaa cccacagaaa    720

tttctctatc ttccaagcca agagcaccaa gaactactcc ctttcttcag ttgaatgaaa    780

taagaaatgt aaaacatgat ggcattcctg ctgaatgtac caccatttat aacagaggtg    840

aacatacaag tggcatgtat gccatcagac ccagcaactc tcaagttttt catgtctact    900

gtgatgttat atcaggtagt ccatggacat taattcaaca tcgaatagat ggatcacaaa    960

acttcaatga aacgtgggag aactacaaat atggttttgg gaggcttgat ggagaatttt    1020

ggttgggcct agagaagata tactccatag tgaagcaatc taattatgtt ttacgaattg    1080

agttggaaga ctggaaagac aacaaacatt atattgaata ttctttttac ttgggaaatc    1140

acgaaaccaa ctatacgcta catctagttg cgattactgg caatgtcccc aatgcaatcc    1200

cggaaaacaa agatttggtg ttttctactt gggatcacaa agcaaaagga cacttcaact    1260

gtccagaggg ttattcagga ggctggtggt ggcatgatga gtgtggagaa aacaacctaa    1320

atggtaaata taacaaacca agagcaaaat ctaagccaga gaggagaaga ggattatctt    1380

ggaagtctca aaatggaagg ttatactcta taaaatcaac caaaatgttg atccatccaa    1440

cagattcaga aagctttgaa tgaactgagg caaatttaaa aggcaataat ttaaacatta    1500

acctcattcc aagttaatgt ggtctaataa tctggtatta aatccttaag agaaagcttg    1560

agaaatagat tttttttatc ttaaagtcac tgtctattta agattaaaca tacaatcaca    1620

taaccttaaa gaataccgtt tacatttctc aatcaaaatt cttataatac tatttgtttt    1680

aaattttgtg atgtgggaat caattttaga tggtcacaat ctagattata atcaataggt    1740

gaacttatta aataactttt ctaaataaaa aatttagaga cttttatttt aaaaggcatc    1800

atatgagcta atatcacaac tttcccagtt taaaaaacta gtactcttgt taaaactcta    1860

aacttgacta aatacagagg actggtaatt gtacagttct taaatgttgt agtattaatt    1920

tcaaaactaa aaatcgtcag cacagagtat gtgtaaaaat ctgtaataca aatttttaaa    1980

ctgatgcttc attttgctac aaaataattt ggagtaaatg tttgatatga tttatttatg    2040

aaacctaatg aagcagaatt aaatactgta ttaaaataag ttcgctgtct ttaaacaaat    2100

ggagatgact actaagtcac attgacttta acatgaggta tcactatacc ttatttgtta    2160

aaatatatac tgtatacatt ttatatattt taacacttaa tactatgaaa acaaataatt    2220

gtaaaggaat cttgtcagat tacagtaaga atgaacatat ttgtggcatc gagttaaagt    2280

ttatatttcc cctaaatatg ctgtgattct aatacattcg tgtaggtttt caagtagaaa    2340

taaacctcgt aacaagttac tgaacgttta aacagcctga caagcatgta tatatgttta    2400

aaattcaata aacaaagacc cagtccctaa attatagaaa tttaaattat tcttgcatgt    2460

ttatcgacat cacaacagat ccctaaatcc ctaaatccct aaagattaga tacaaatttt    2520

ttaccacagt atcacttgtc agaatttatt tttaaatatg attttttaaa actgccagta    2580

agaaatttta aattaaaccc atttgttaaa ggatatagtg cccaagttat atggtgacct    2640

acctttgtca atacttagca ttatgtattt caaattatcc aatatacatg tcatatatat    2700

ttttatatgt cacatatata aaagatatgt atgatctatg tgaatcctaa gtaaatattt    2760

tgttccagaa aagtacaaaa taataaaggt aaaaataatc tataattttc aggaccacag    2820

actaagctgt cgaaattaac gctgattttt ttagggccag aataccaaaa tggctcctct    2880

cttcccccaa aattggacaa tttcaaatgc aaaataattc attatttaat atatgagttg    2940

cttcctctat t                                                         2951


<210>  2
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  2
uacugaucaa auauguugag c                                                 21


<210>  3
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  3
uacugaucaa auauguugag c                                                 21


<210>  4
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  4
uacugaucaa auauguugag c                                                 21


<210>  5
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  5
uacugaucaa auauguugag u                                                 21


<210>  6
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  6
uacugaucaa auauguugag u                                                 21


<210>  7
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  7
uuugaauuaa uguccauggg c                                                 21


<210>  8
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  8
uuugaauuaa uguccauggg c                                                 21


<210>  9
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  9
uuugaauuaa uguccauggg u                                                 21


<210>  10
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  10
uuugaauuaa uguccauggg u                                                 21


<210>  11
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  11
uguugaauua auguccaugg a                                                 21


<210>  12
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  12
uguugaauua auguccaugg a                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  13
uguugaauua auguccaugg a                                                 21


<210>  14
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  14
acaucgucua acauagcaac c                                                 21


<210>  15
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  15
acaucgucua acauagcaac c                                                 21


<210>  16
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  16
gcucaacaua uuugaucagu a                                                 21


<210>  17
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  17
gcucaacaua uuugaucagu a                                                 21



<210>  18
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  10
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  18
gcucaacaun uuugaucagu a                                                 21


<210>  19
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  10
<223>  n = 2-aminoadenine

<400>  19
gcucaacaun uuugaucagu a                                                 21


<210>  20
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  8, 10
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  20
gcucaacnun uuugaucagu a                                                 21


<210>  21
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  8, 10
<223>  n = 2-aminoadenine

<400>  21
gcucaacnun uuugaucagu a                                                 21


<210>  22
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  22
gcucaacaua uuugaucagu a                                                 21


<210>  23
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  23
acucaacaua uuugaucagu a                                                 21


<210>  24
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  24
acucaacaua uuugaucagu a                                                 21


<210>  25
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  25
gcccauggac auuaauucaa a                                                 21


<210>  26
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  26
gcccauggac auuaauucaa a                                                 21


<210>  27
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  27
acccauggac auuaauucaa a                                                 21


<210>  28
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  28
acccauggac auuaauucaa a                                                 21


<210>  29
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  29
uccauggaca uuaauucaac a                                                 21


<210>  30
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  30
uccauggaca uuaauucaac a                                                 21


<210>  31
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  31
gguugcuaug uuagacgaug u                                                 21


<210>  32
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  32
gguugcuaug uuagacgaug u                                                 21


<210>  33
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ANGPTL3 gene transcript (mRNA) target sequence

<400>  33
ucaacauauu ugaucaguc                                                    19


<210>  34
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ANGPTL3 gene transcript (mRNA) target sequence

<400>  34
cauggacauu aauucaaca                                                    19


<210>  35
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ANGPTL3 gene transcript (mRNA) target sequence

<400>  35
ccauggacau uaauucaac                                                    19


<210>  36
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ANGPTL3 gene transcript (mRNA) target sequence

<400>  36
uugcuauguu agacgaugu                                                    19


<210>  37
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ANGPTL3 gene transcript (mRNA) target sequence

<400>  37
aagauauacu ccauaguga                                                    19


<210>  38
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ANGPTL3 gene transcript (mRNA) target sequence

<400>  38
cagagccaaa aucaagauu                                                    19


<210>  39
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ANGPTL3 gene transcript (mRNA) target sequence

<400>  39
gacauggucu uaaagacuu                                                    19


<210>  40
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ANGPTL3 gene transcript (mRNA) target sequence

<400>  40
agcaccaaga acuacuccc                                                    19


<210>  41
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ANGPTL3 gene transcript (mRNA) target sequence

<400>  41
gcaccaagaa cuacucccu                                                    19


<210>  42
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ANGPTL3 gene transcript (mRNA) target sequence

<400>  42
gauggagaau uuugguugg                                                    19


<210>  43
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ANGPTL3 gene transcript (mRNA) target sequence

<400>  43
auggagaauu uugguuggg                                                    19


<210>  44
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ANGPTL3 gene transcript (mRNA) target sequence

<400>  44
acuccauagu gaagcaauc                                                    19


<210>  45
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ANGPTL3 gene transcript (mRNA) target sequence

<400>  45
cacgaaacca acuauacgc                                                    19


<210>  46
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ANGPTL3 gene transcript (mRNA) target sequence

<400>  46
cuacuuggga ucacaaagc                                                    19


<210>  47
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ANGPTL3 gene transcript (mRNA) target sequence

<400>  47
cuugggauca caaagcaaa                                                    19


<210>  48
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ANGPTL3 gene transcript (mRNA) target sequence

<400>  48
uguggagaaa acaaccuaa                                                    19


<210>  49
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ANGPTL3 gene transcript (mRNA) target sequence

<400>  49
uggagaaaac aaccuaaau                                                    19


<210>  50
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  50
uacugaucaa auauguuga                                                    19


<210>  51
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  51
aacugaucaa auauguuga                                                    19


<210>  52
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  52
gacugaucaa auauguuga                                                    19


<210>  53
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase 

<400>  53
nacugaucaa auauguuga                                                    19


<210>  54
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  54
nacugaucaa auauguugn                                                    19


<210>  55
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  55
uguugaauua auguccaug                                                    19


<210>  56
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  56
aguugaauua auguccaug                                                    19


<210>  57
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase 

<400>  57
nguugaauua auguccaug                                                    19


<210>  58
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase 

<400>  58
nguugaauua auguccaun                                                    19


<210>  59
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  59
guugaauuaa uguccaugg                                                    19


<210>  60
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  60
uuugaauuaa uguccaugg                                                    19


<210>  61
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  61
auugaauuaa uguccaugg                                                    19


<210>  62
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase 

<400>  62
nuugaauuaa uguccaugg                                                    19


<210>  63
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase 

<400>  63
nuugaauuaa uguccaugn                                                    19


<210>  64
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  64
acaucgucua acauagcaa                                                    19


<210>  65
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  65
ucaucgucua acauagcaa                                                    19


<210>  66
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase 

<400>  66
ncaucgucua acauagcaa                                                    19


<210>  67
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase 

<400>  67
ncaucgucua acauagcan                                                    19


<210>  68
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  68
ucacuaugga guauaucuu                                                    19


<210>  69
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  69
acacuaugga guauaucuu                                                    19


<210>  70
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase 

<400>  70
ncacuaugga guauaucuu                                                    19


<210>  71
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  71
ncacuaugga guauaucun                                                    19


<210>  72
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  72
aaucuugauu uuggcucug                                                    19


<210>  73
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  73
uaucuugauu uuggcucug                                                    19


<210>  74
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  74
naucuugauu uuggcucug                                                    19


<210>  75
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  75
naucuugauu uuggcucun                                                    19


<210>  76
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  76
aagucuuuaa gaccauguc                                                    19


<210>  77
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  77
uagucuuuaa gaccauguc                                                    19


<210>  78
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  78
nagucuuuaa gaccauguc                                                    19


<210>  79
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  79
nagucuuuaa gaccaugun                                                    19


<210>  80
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  80
gggaguaguu cuuggugcu                                                    19


<210>  81
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  81
uggaguaguu cuuggugcu                                                    19


<210>  82
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  82
aggaguaguu cuuggugcu                                                    19


<210>  83
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  83
nggaguaguu cuuggugcu                                                    19


<210>  84
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  84
nggaguaguu cuuggugcn                                                    19


<210>  85
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  85
agggaguagu ucuuggugc                                                    19


<210>  86
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  86
ugggaguagu ucuuggugc                                                    19


<210>  87
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  87
ngggaguagu ucuuggugc                                                    19


<210>  88
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  88
ngggaguagu ucuuggugn                                                    19


<210>  89
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  89
agagaguagu ucuuggugc                                                    19


<210>  90
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  90
ugagaguagu ucuuggugc                                                    19


<210>  91
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  91
ngagaguagu ucuuggugc                                                    19


<210>  92
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  92
ngagaguagu ucuuggugn                                                    19


<210>  93
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  93
ccaaccaaaa uucuccauc                                                    19


<210>  94
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  94
ucaaccaaaa uucuccauc                                                    19


<210>  95
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  95
acaaccaaaa uucuccauc                                                    19


<210>  96
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  96
ncaaccaaaa uucuccauc                                                    19


<210>  97
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  97
ncaaccaaaa uucuccaun                                                    19


<210>  98
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  98
cccaaccaaa auucuccau                                                    19


<210>  99
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  99
uccaaccaaa auucuccau                                                    19


<210>  100
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  100
accaaccaaa auucuccau                                                    19


<210>  101
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  101
nccaaccaaa auucuccau                                                    19


<210>  102
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  102
nccaaccaaa auucuccan                                                    19


<210>  103
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  103
uauugcuuca cuauggagu                                                    19


<210>  104
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  104
aauugcuuca cuauggagu                                                    19


<210>  105
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  105
gauugcuuca cuauggagu                                                    19


<210>  106
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase 

<400>  106
nauugcuuca cuauggagu                                                    19


<210>  107
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase 

<400>  107
nauugcuuca cuauggagn                                                    19


<210>  108
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  108
ucguauaguu gguuucgug                                                    19


<210>  109
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  109
acguauaguu gguuucgug                                                    19


<210>  110
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  110
gcguauaguu gguuucgug                                                    19


<210>  111
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase 

<400>  111
ncguauaguu gguuucgug                                                    19


<210>  112
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase 

<400>  112
ncguauaguu gguuucgun                                                    19


<210>  113
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  113
ucuuugugau cccaaguag                                                    19


<210>  114
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  114
acuuugugau cccaaguag                                                    19


<210>  115
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  115
gcuuugugau cccaaguag                                                    19


<210>  116
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase 

<400>  116
ncuuugugau cccaaguag                                                    19


<210>  117
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  117
ncuuugugau cccaaguan                                                    19


<210>  118
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  118
uuugcuuugu gaucccaag                                                    19


<210>  119
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  119
auugcuuugu gaucccaag                                                    19


<210>  120
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  120
nuugcuuugu gaucccaag                                                    19


<210>  121
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  121
nuugcuuugu gaucccaan                                                    19


<210>  122
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  122
uuagguuguu uucuccaca                                                    19


<210>  123
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  123
auagguuguu uucuccaca                                                    19


<210>  124
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  124
nuagguuguu uucuccaca                                                    19


<210>  125
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  125
nuagguuguu uucuccacn                                                    19


<210>  126
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  126
auuuagguug uuuucucca                                                    19


<210>  127
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  127
uuuuagguug uuuucucca                                                    19


<210>  128
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  128
nuuuagguug uuuucucca                                                    19


<210>  129
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase 

<400>  129
nuuuagguug uuuucuccn                                                    19


<210>  130
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  130
ucaacauauu ugaucagua                                                    19


<210>  131
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  8
<223>  n = 2-aminoadenine

<400>  131
ucaacaunuu ugaucagua                                                    19


<210>  132
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  6, 8
<223>  n = 2-aminoadenine

<400>  132
ucaacnunuu ugaucagua                                                    19


<210>  133
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  133
ucaacauauu ugaucaguu                                                    19


<210>  134
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  8
<223>  n = 2-aminoadenine

<400>  134
ucaacaunuu ugaucaguu                                                    19


<210>  135
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  6, 8
<223>  n = 2-aminoadenine

<400>  135
ucaacnunuu ugaucaguu                                                    19


<210>  136
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  136
ucaacauauu ugaucaguc                                                    19


<210>  137
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  8
<223>  n = 2-aminoadenine

<400>  137
ucaacaunuu ugaucaguc                                                    19


<210>  138
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  6, 8
<223>  n = 2-aminoadenine

<400>  138
ucaacnunuu ugaucaguc                                                    19


<210>  139
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase 

<400>  139
ucaacauauu ugaucagun                                                    19


<210>  140
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  8
<223>  n = 2-aminoadenine

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase 

<400>  140
ucaacaunuu ugaucagun                                                    19


<210>  141
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  6, 8
<223>  n = 2-aminoadenine

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  141
ucaacnunuu ugaucagun                                                    19


<210>  142
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase 

<400>  142
ncaacauauu ugaucagun                                                    19


<210>  143
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<220>
<221>  modified_base
<222>  8
<223>  n = 2-aminoadenine

<400>  143
ncaacaunuu ugaucagun                                                    19


<210>  144
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<220>
<221>  modified_base
<222>  6, 8
<223>  n = 2-aminoadenine

<400>  144
ncaacnunuu ugaucagun                                                    19


<210>  145
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  145
cauggacauu aauucaaca                                                    19


<210>  146
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  146
cauggacauu aauucaacu                                                    19


<210>  147
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase 

<400>  147
cauggacauu aauucaacn                                                    19


<210>  148
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase 

<400>  148
nauggacauu aauucaacn                                                    19


<210>  149
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  149
ccauggacau uaauucaac                                                    19


<210>  150
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  150
ccauggacau uaauucaaa                                                    19


<210>  151
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  151
ccauggacau uaauucaau                                                    19


<210>  152
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  152
ccauggacau uaauucaan                                                    19


<210>  153
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  153
ncauggacau uaauucaan                                                    19


<210>  154
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  154
uugcuauguu agacgaugu                                                    19


<210>  155
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  155
uugcuauguu agacgauga                                                    19


<210>  156
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  156
uugcuauguu agacgaugn                                                    19


<210>  157
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase 

<400>  157
nugcuauguu agacgaugn                                                    19


<210>  158
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  158
aagauauacu ccauaguga                                                    19


<210>  159
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  159
aagauauacu ccauagugu                                                    19


<210>  160
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  160
aagauauacu ccauagugn                                                    19


<210>  161
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  161
nagauauacu ccauagugn                                                    19


<210>  162
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  162
cagagccaaa aucaagauu                                                    19


<210>  163
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  163
cagagccaaa aucaagaua                                                    19


<210>  164
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  164
cagagccaaa aucaagaun                                                    19


<210>  165
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  165
nagagccaaa aucaagaun                                                    19


<210>  166
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  166
gacauggucu uaaagacuu                                                    19


<210>  167
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  167
gacauggucu uaaagacua                                                    19


<210>  168
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  168
gacauggucu uaaagacun                                                    19


<210>  169
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  169
nacauggucu uaaagacun                                                    19


<210>  170
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  170
agcaccaaga acuacuccc                                                    19


<210>  171
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  171
agcaccaaga acuacucca                                                    19


<210>  172
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  172
agcaccaaga acuacuccu                                                    19


<210>  173
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  173
agcaccaaga acuacuccn                                                    19


<210>  174
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  174
ngcaccaaga acuacuccn                                                    19


<210>  175
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  175
gcaccaagaa cuacucccu                                                    19


<210>  176
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  176
gcaccaagaa cuacuccca                                                    19


<210>  177
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  177
gcaccaagaa cuacucccn                                                    19


<210>  178
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  178
ncaccaagaa cuacucccn                                                    19


<210>  179
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  179
gcaccaagaa cuacucucu                                                    19


<210>  180
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  180
gcaccaagaa cuacucuca                                                    19


<210>  181
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  181
gcaccaagaa cuacucucn                                                    19


<210>  182
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  182
ncaccaagaa cuacucucn                                                    19


<210>  183
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  183
gauggagaau uuugguugg                                                    19


<210>  184
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  184
gauggagaau uuugguuga                                                    19


<210>  185
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  185
gauggagaau uuugguugu                                                    19


<210>  186
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase 

<400>  186
gauggagaau uuugguugn                                                    19


<210>  187
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  187
nauggagaau uuugguugn                                                    19


<210>  188
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  188
auggagaauu uugguuggg                                                    19


<210>  189
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  189
auggagaauu uugguugga                                                    19


<210>  190
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  190
auggagaauu uugguuggu                                                    19


<210>  191
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  191
auggagaauu uugguuggn                                                    19


<210>  192
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  192
nuggagaauu uugguuggn                                                    19


<210>  193
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  193
acuccauagu gaagcaaua                                                    19


<210>  194
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  194
acuccauagu gaagcaauu                                                    19


<210>  195
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  195
acuccauagu gaagcaauc                                                    19


<210>  196
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  196
acuccauagu gaagcaaun                                                    19


<210>  197
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  197
acuccauagu gaagcaaun                                                    19


<210>  198
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  198
cacgaaacca acuauacga                                                    19


<210>  199
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  199
cacgaaacca acuauacgu                                                    19


<210>  200
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  200
cacgaaacca acuauacgc                                                    19


<210>  201
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase 

<400>  201
cacgaaacca acuauacgn                                                    19


<210>  202
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  202
nacgaaacca acuauacgn                                                    19


<210>  203
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  203
cuacuuggga ucacaaaga                                                    19


<210>  204
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  204
cuacuuggga ucacaaagu                                                    19


<210>  205
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  205
cuacuuggga ucacaaagc                                                    19


<210>  206
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  206
cuacuuggga ucacaaagn                                                    19


<210>  207
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  207
nuacuuggga ucacaaagn                                                    19


<210>  208
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  208
cuugggauca caaagcaaa                                                    19


<210>  209
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  209
cuugggauca caaagcaau                                                    19


<210>  210
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  210
cuugggauca caaagcaan                                                    19


<210>  211
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  211
nuugggauca caaagcaan                                                    19


<210>  212
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  212
uguggagaaa acaaccuaa                                                    19


<210>  213
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  213
uguggagaaa acaaccuau                                                    19


<210>  214
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  214
uguggagaaa acaaccuan                                                    19


<210>  215
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  215
nguggagaaa acaaccuan                                                    19


<210>  216
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  216
uggagaaaac aaccuaaau                                                    19


<210>  217
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  217
uggagaaaac aaccuaaaa                                                    19


<210>  218
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  218
uggagaaaac aaccuaaan                                                    19


<210>  219
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  219
nggagaaaac aaccuaaan                                                    19


<210>  220
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  220
uuugaauuaa uguccaugga c                                                 21


<210>  221
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  221
uguugaauua auguccaugg c                                                 21


<210>  222
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  222
uuagguuguu uucuccacac u                                                 21


<210>  223
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  223
uuagguuguu uucuccacac c                                                 21


<210>  224
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  224
uuuuagguug uuuucuccac c                                                 21


<210>  225
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  225
uggaguaguu cuuggugcuc u                                                 21


<210>  226
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  226
uggaguaguu cuuggugcuc c                                                 21


<210>  227
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  227
agggaguagu ucuuggugcu c                                                 21


<210>  228
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  228
uuugaauuaa uguccaugga g                                                 21


<210>  229
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  229
uuugaauuaa uguccaugga g                                                 21


<210>  230
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  230
uuugaauuaa uguccauggc g                                                 21


<210>  231
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  231
uuugaauuaa uguccauggg g                                                 21


<210>  232
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  232
uguugaauua auguccaugg g                                                 21


<210>  233
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  233
uguugaauua auguccaugg u                                                 21


<210>  234
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  234
uguugaauua auguccaugg u                                                 21


<210>  235
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  235
aaucuugauu uuggcucugg a                                                 21


<210>  236
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  236
aaucuugauu uuggcucugg u                                                 21


<210>  237
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  237
ucaaccaaaa uucuccauca c                                                 21


<210>  238
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  238
ucaaccaaaa uucuccaucg c                                                 21


<210>  239
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  239
uccaaccaaa auucuccauc a                                                 21


<210>  240
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  240
uguugaauua auguccaugg a                                                 21


<210>  241
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  241
uguugaauua auguccaugg a                                                 21


<210>  242
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  242
uguugaauua auguccaugg a                                                 21


<210>  243
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  243
uguugaauua auguccaugg a                                                 21


<210>  244
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  244
uguugaauua auguccaugg a                                                 21


<210>  245
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  245
uguugaauua auguccaugg a                                                 21


<210>  246
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  246
uguugaauua auguccaugg g                                                 21


<210>  247
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  247
aacugaucaa auauguugag c                                                 21


<210>  248
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  248
uacugaucaa auauguugag c                                                 21


<210>  249
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  249
uacugaucaa auauguugag c                                                 21


<210>  250
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  250
uacugaucaa auauguugag c                                                 21


<210>  251
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  251
uacugaucaa auauguugag g                                                 21


<210>  252
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  252
uacugaucaa auauguuggg c                                                 21


<210>  253
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  253
uacugaucaa auauguugcg c                                                 21


<210>  254
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  254
uacugaucaa auauguuggg u                                                 21


<210>  255
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  255
uacugaucaa auauguugcg u                                                 21


<210>  256
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  256
uutgaauuaa uguccauggg u                                                 21


<210>  257
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  257
uuugaauuaa uguccauggg u                                                 21


<210>  258
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  258
uuugaatuaa uguccauggg u                                                 21


<210>  259
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  259
uutgaauuaa uguccauggg u                                                 21


<210>  260
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  260
uacugaucaa auauguugag c                                                 21


<210>  261
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  261
uacugaucaa auauguugag c                                                 21


<210>  262
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  262
uacugaucaa auauguugag c                                                 21


<210>  263
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<220>
<221>  modified_base
<222>  11
<223>  n = 2'-O-methylinosine-3'-phosphate

<400>  263
uacugaucaa nuauguugag c                                                 21


<210>  264
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  264
uacugaucaa auauguugag c                                                 21


<210>  265
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  265
uacugaucaa auauguugag c                                                 21


<210>  266
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  266
uuugaauuaa uguccauggg u                                                 21


<210>  267
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  267
aagucuuuaa gaccaugucc c                                                 21


<210>  268
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  268
uauugcuuca cuauggagua g                                                 21


<210>  269
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  269
uuugcuuugu gaucccaagu c                                                 21


<210>  270
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  270
ucacuaugga guauaucuuc c                                                 21


<210>  271
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  271
ucguauaguu gguuucguga c                                                 21


<210>  272
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  272
ucuuugugau cccaaguaga c                                                 21


<210>  273
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  273
ucacuaugga guauaucuuc c                                                 21


<210>  274
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  274
agagcaccaa gaacuacucc a                                                 21


<210>  275
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  275
ggagcaccaa gaacuacuuc a                                                 21


<210>  276
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  276
gagcaccaag aacuacucuc u                                                 21


<210>  277
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  277
guccauggac auuaauucaa a                                                 21


<210>  278
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  278
gcccauggac auuaauucaa a                                                 21


<210>  279
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  279
uccauggaca uuaauucaac a                                                 21


<210>  280
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  280
gccauggaca uuaauucaac a                                                 21


<210>  281
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  281
aguguggaga aaacaaccua a                                                 21


<210>  282
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  282
gguguggaga aaacaaccua a                                                 21


<210>  283
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  283
gguggagaaa acaaccuaaa a                                                 21


<210>  284
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  284
cuccauggac auuaauucaa a                                                 21


<210>  285
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  285
cuccauggac auuaauucaa a                                                 21


<210>  286
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  286
cuccauggac auuaauucaa a                                                 21


<210>  287
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  20
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  287
cuccauggac auuaauucan a                                                 21


<210>  288
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  19
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  288
cuccauggac auuaauucna a                                                 21


<210>  289
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  14
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  289
cuccauggac auunauucaa a                                                 21


<210>  290
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  290
cgccauggac auuaauucaa a                                                 21


<210>  291
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  291
ccccauggac auuaauucaa a                                                 21


<210>  292
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  292
acccauggac auuaauucaa a                                                 21


<210>  293
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  293
cccauggaca uuaauucaac a                                                 21


<210>  294
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  294
accauggaca uuaauucaac a                                                 21


<210>  295
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  295
accauggaca uuaauucaac a                                                 21


<210>  296
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  14
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  296
accauggaca uuanuucaac a                                                 21


<210>  297
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  4
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  297
accnuggaca uuaauucaac a                                                 21


<210>  298
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  1
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  298
nccauggaca uuaauucaac a                                                 21


<210>  299
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  299
acucaacaua uuugaucagu a                                                 21


<210>  300
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  300
gcucaacaua uuugaucagu a                                                 21


<210>  301
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  301
uccagagcca aaaucaagau u                                                 21


<210>  302
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  302
accagagcca aaaucaagau u                                                 21


<210>  303
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  303
gugauggaga auuuugguug a                                                 21


<210>  304
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  304
gcgauggaga auuuugguug a                                                 21


<210>  305
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  305
ugauggagaa uuuugguugg a                                                 21


<210>  306
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  306
uccauggaca uuaauucaac a                                                 21


<210>  307
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  307
accauggaca uuaauucaac a                                                 21


<210>  308
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  19
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  308
uccauggaca uuaauucanc a                                                 21


<210>  309
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  18
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  309
uccauggaca uuaauucnac a                                                 21


<210>  310
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  310
uccauggaca uuaauucaac a                                                 21


<210>  311
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  311
uccauggaca uuaauucaac a                                                 21


<210>  312
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  312
uccauggaca uuaauucaac a                                                 21


<210>  313
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  313
cccauggaca uuaauucaac a                                                 21


<210>  314
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  314
acccauggac auuaauucaa a                                                 21


<210>  315
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  315
gcucaacaua uuugaucagu u                                                 21


<210>  316
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  19
<223>  n = 2'-O-methylinosine-3'-phosphate

<400>  316
gcucaacaua uuugaucanu a                                                 21


<210>  317
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  317
gcucaacaua uuugaucagu a                                                 21


<210>  318
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  318
ccucaacaua uuugaucagu a                                                 21


<210>  319
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  319
gcccaacaua uuugaucagu a                                                 21


<210>  320
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  320
gcgcaacaua uuugaucagu a                                                 21


<210>  321
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  321
acccaacaua uuugaucagu a                                                 21


<210>  322
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  322
acgcaacaua uuugaucagu a                                                 21


<210>  323
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  323
acccauggac auuaauucaa a                                                 21


<210>  324
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  324
acccauggac auuaauucaa a                                                 21


<210>  325
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  325
acccauggac auuaatucaa a                                                 21


<210>  326
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  326
gcucaacaua uuugaucagu a                                                 21


<210>  327
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  327
gcucaacaua uuugaucagu a                                                 21


<210>  328
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  328
gcucaacaua uuugaucagu a                                                 21


<210>  329
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  329
gcucaacaua uuugaucagu a                                                 21


<210>  330
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  330
gcucaacaua uuugaucagu a                                                 21


<210>  331
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  331
gcucaacaua uuugaucagu a                                                 21


<210>  332
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  332
gcucaacaua uuugaucagu a                                                 21


<210>  333
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  15
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  333
gcucaacaua uuugnucagu a                                                 21


<210>  334
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  10
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  334
gcucaacaun uuugaucagu a                                                 21


<210>  335
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  8
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  335
gcucaacnua uuugaucagu a                                                 21


<210>  336
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  8, 10
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  336
gcucaacnun uuugaucagu a                                                 21


<210>  337
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  337
gcucaacaua uuugaucagu a                                                 21


<210>  338
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  338
gcucaacaua uuugaucagu a                                                 21


<210>  339
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  339
gcucaacaua uuugaucagu a                                                 21


<210>  340
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  340
gcucaacaua uuugaucagu a                                                 21


<210>  341
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  341
gcucaacaua uuugaucagu a                                                 21


<210>  342
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  342
gcucaacaua uuugaucagu a                                                 21


<210>  343
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  343
gcucaacaua uuugaucagu a                                                 21


<210>  344
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  344
gcucaacaua uuugaucagu a                                                 21


<210>  345
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  345
gcucaacaua uuugaucagu a                                                 21


<210>  346
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  346
acccauggac auuaauucaa a                                                 21


<210>  347
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  347
acccauggac auuaauucaa a                                                 21


<210>  348
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  348
acccauggac auuaauucaa a                                                 21


<210>  349
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  349
acccauggac auuaauucaa a                                                 21


<210>  350
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  350
acccauggac auuaatucaa a                                                 21


<210>  351
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  351
acccauggac auuaauucaa a                                                 21


<210>  352
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  352
acccauggac auuaatucaa a                                                 21


<210>  353
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  353
acccauggac auuaauucaa a                                                 21


<210>  354
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  354
gggacauggu cuuaaagacu u                                                 21


<210>  355
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  355
cuacuccaua gugaagcaau a                                                 21


<210>  356
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  356
gacuugggau cacaaagcaa a                                                 21


<210>  357
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  357
gguugcuaug uuagacgaug u                                                 21


<210>  358
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  358
ggaagauaua cuccauagug a                                                 21


<210>  359
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  359
gucacgaaac caacuauacg a                                                 21


<210>  360
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  360
gucuacuugg gaucacaaag a                                                 21


<210>  361
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  361
ggaagauaua cuccauagug a                                                 21


<210>  362
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  18
<223>  n = 2'-O-methylinosine-3'-phosphate

<400>  362
ggaagauaua cuccauanug a                                                 21


<210>  363
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  363
uuugaauuaa uguccaugga c                                                 21


<210>  364
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  364
uguugaauua auguccaugg c                                                 21


<210>  365
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  365
uuagguuguu uucuccacac u                                                 21


<210>  366
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  366
uuagguuguu uucuccacac c                                                 21


<210>  367
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  367
uuuuagguug uuuucuccac c                                                 21


<210>  368
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  368
uggaguaguu cuuggugcuc u                                                 21


<210>  369
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  369
uggaguaguu cuuggugcuc c                                                 21


<210>  370
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  370
agggaguagu ucuuggugcu c                                                 21


<210>  371
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  371
uuugaauuaa uguccaugga g                                                 21


<210>  372
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  372
uuugaauuaa uguccauggc g                                                 21


<210>  373
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  373
uuugaauuaa uguccauggg g                                                 21


<210>  374
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  374
uguugaauua auguccaugg g                                                 21


<210>  375
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  375
uguugaauua auguccaugg u                                                 21


<210>  376
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  376
aaucuugauu uuggcucugg a                                                 21


<210>  377
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  377
aaucuugauu uuggcucugg u                                                 21


<210>  378
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  378
ucaaccaaaa uucuccauca c                                                 21


<210>  379
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  379
ucaaccaaaa uucuccaucg c                                                 21


<210>  380
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  380
uccaaccaaa auucuccauc a                                                 21


<210>  381
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  381
uguugaauua auguccaugg a                                                 21


<210>  382
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  382
aacugaucaa auauguugag c                                                 21


<210>  383
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  383
uacugaucaa auauguugag c                                                 21


<210>  384
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  384
uacugaucaa auauguugag c                                                 21


<210>  385
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  385
uacugaucaa auauguugag g                                                 21


<210>  386
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  386
uacugaucaa auauguuggg c                                                 21


<210>  387
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  387
uacugaucaa auauguugcg c                                                 21


<210>  388
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  388
uacugaucaa auauguuggg u                                                 21


<210>  389
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  389
uacugaucaa auauguugcg u                                                 21


<210>  390
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  390
uutgaauuaa uguccauggg u                                                 21


<210>  391
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  391
uuugaauuaa uguccauggg u                                                 21


<210>  392
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  392
uuugaatuaa uguccauggg u                                                 21


<210>  393
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<220>
<221>  modified_base
<222>  11
<223>  n = inosine (hypoxanthine)

<400>  393
uacugaucaa nuauguugag c                                                 21


<210>  394
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  394
aagucuuuaa gaccaugucc c                                                 21


<210>  395
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  395
uauugcuuca cuauggagua g                                                 21


<210>  396
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  396
uuugcuuugu gaucccaagu c                                                 21


<210>  397
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  397
ucacuaugga guauaucuuc c                                                 21


<210>  398
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  398
ucguauaguu gguuucguga c                                                 21


<210>  399
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  399
ucuuugugau cccaaguaga c                                                 21


<210>  400
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  400
agagcaccaa gaacuacucc a                                                 21


<210>  401
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  401
ggagcaccaa gaacuacuuc a                                                 21


<210>  402
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  402
gagcaccaag aacuacucuc u                                                 21


<210>  403
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  403
guccauggac auuaauucaa a                                                 21


<210>  404
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  404
gcccauggac auuaauucaa a                                                 21


<210>  405
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  405
uccauggaca uuaauucaac a                                                 21


<210>  406
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  406
gccauggaca uuaauucaac a                                                 21


<210>  407
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  407
aguguggaga aaacaaccua a                                                 21


<210>  408
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  408
gguguggaga aaacaaccua a                                                 21


<210>  409
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  409
gguggagaaa acaaccuaaa a                                                 21


<210>  410
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  410
cuccauggac auuaauucaa a                                                 21


<210>  411
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  20
<223>  n = 2-aminoadenine

<400>  411
cuccauggac auuaauucan a                                                 21


<210>  412
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = 2-aminoadenine

<400>  412
cuccauggac auuaauucna a                                                 21


<210>  413
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  14
<223>  n = 2-aminoadenine

<400>  413
cuccauggac auunauucaa a                                                 21


<210>  414
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  414
cgccauggac auuaauucaa a                                                 21


<210>  415
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  415
ccccauggac auuaauucaa a                                                 21


<210>  416
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  416
acccauggac auuaauucaa a                                                 21


<210>  417
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  417
cccauggaca uuaauucaac a                                                 21


<210>  418
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  418
accauggaca uuaauucaac a                                                 21


<210>  419
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  14
<223>  n = 2-aminoadenine

<400>  419
accauggaca uuanuucaac a                                                 21


<210>  420
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  4
<223>  n = 2-aminoadenine

<400>  420
accnuggaca uuaauucaac a                                                 21


<210>  421
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = 2-aminoadenine

<400>  421
nccauggaca uuaauucaac a                                                 21


<210>  422
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  422
acucaacaua uuugaucagu a                                                 21


<210>  423
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  423
gcucaacaua uuugaucagu a                                                 21


<210>  424
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  424
uccagagcca aaaucaagau u                                                 21


<210>  425
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  425
accagagcca aaaucaagau u                                                 21


<210>  426
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  426
gugauggaga auuuugguug a                                                 21


<210>  427
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  427
gcgauggaga auuuugguug a                                                 21


<210>  428
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  428
ugauggagaa uuuugguugg a                                                 21


<210>  429
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = 2-aminoadenine

<400>  429
uccauggaca uuaauucanc a                                                 21


<210>  430
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  18
<223>  n = 2-aminoadenine

<400>  430
uccauggaca uuaauucnac a                                                 21


<210>  431
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  431
gcucaacaua uuugaucagu u                                                 21


<210>  432
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = inosine (hypoxanthine) 

<400>  432
gcucaacaua uuugaucanu a                                                 21


<210>  433
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  433
ccucaacaua uuugaucagu a                                                 21


<210>  434
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  434
gcccaacaua uuugaucagu a                                                 21


<210>  435
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  435
gcgcaacaua uuugaucagu a                                                 21


<210>  436
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  436
acccaacaua uuugaucagu a                                                 21


<210>  437
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  437
acgcaacaua uuugaucagu a                                                 21


<210>  438
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  438
acccauggac auuaatucaa a                                                 21


<210>  439
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  15
<223>  n = 2-aminoadenine

<400>  439
gcucaacaua uuugnucagu a                                                 21


<210>  440
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  10
<223>  n = 2-aminoadenine

<400>  440
gcucaacaun uuugaucagu a                                                 21


<210>  441
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  8
<223>  n = 2-aminoadenine

<400>  441
gcucaacnua uuugaucagu a                                                 21


<210>  442
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  8, 10
<223>  n = 2-aminoadenine

<400>  442
gcucaacnun uuugaucagu a                                                 21


<210>  443
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  443
gggacauggu cuuaaagacu u                                                 21


<210>  444
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  444
cuacuccaua gugaagcaau a                                                 21


<210>  445
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  445
gacuugggau cacaaagcaa a                                                 21


<210>  446
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  446
gguugcuaug uuagacgaug u                                                 21


<210>  447
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  447
ggaagauaua cuccauagug a                                                 21


<210>  448
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  448
gucacgaaac caacuauacg a                                                 21


<210>  449
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  449
gucuacuugg gaucacaaag a                                                 21


<210>  450
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  18
<223>  n = inosine (hypoxanthine)

<400>  450
ggaagauaua cuccauanug a                                                 21