                         SEQUENCE LISTING

<110>  GINKGO BIOWORKS, INC.
 
<120>  PROTECTIVE ENZYMES

<130>  2011832-0174

<150>  US 62/557,544
<151>  2017-09-12

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  547
<212>  PRT
<213>  Oscillatoria nigro-viridis

<400>  1

Thr Arg Asp Thr Ser Arg Asp Gly Phe Ser Asn Lys Ala Leu Ala Tyr 
1               5                   10                  15      


Thr Leu Thr His Phe Lys Pro Ile Trp Asn Leu Val Gln Ser Tyr Glu 
            20                  25                  30          


Pro Leu Lys Arg Lys Leu Asn Lys Phe Phe Leu Asn Ser Ile Ile Tyr 
        35                  40                  45              


Lys Leu Pro Thr Arg Pro Leu Pro Tyr Ser Leu Met Gly Leu Asp Pro 
    50                  55                  60                  


Lys Ile Pro Gly Thr Asp Ile Pro Lys Lys Thr Asp Thr Tyr Ile Ser 
65                  70                  75                  80  


Trp Asp Ser Leu Thr Asp Lys Thr Tyr Thr Gly Arg His Leu Pro Pro 
                85                  90                  95      


Asp Pro Glu Phe Asn Lys Glu Gly Asn Leu Pro Pro Leu Asp Lys Val 
            100                 105                 110         


Lys Thr Leu Phe Gln Lys Arg Asp Gly Lys Thr Ile Tyr Ser Glu Lys 
        115                 120                 125             


Ser Thr Leu Leu Phe Pro Tyr Trp Val Gln Trp Phe Thr Asp Ser Phe 
    130                 135                 140                 


Leu Arg Ile Asp Gln Glu Asn Arg Phe Lys Asn Thr Ser Asn His Gln 
145                 150                 155                 160 


Ile Asp Met Cys Asn Val Tyr Gly Leu Thr Arg Lys Gln Thr Asn Met 
                165                 170                 175     


Leu Arg Ala Phe Lys Asp Gly Lys Phe Lys Thr Gln Lys Leu Lys Arg 
            180                 185                 190         


Lys Asp Gly Val Glu Glu Glu Tyr Pro Leu Phe Tyr Tyr Ala Asp Pro 
        195                 200                 205             


Glu Gln Gly Ile Ile Asp Pro Gln Phe Glu Gly Leu His Ala Pro Leu 
    210                 215                 220                 


Asn Asp Glu Lys Arg Gln Pro Pro Glu Lys Lys Ser Lys Leu Phe Ala 
225                 230                 235                 240 


Met Gly Val Glu Arg Ala Asn Val Gln Ile Gly Tyr Val Met Leu Asn 
                245                 250                 255     


Thr Leu Cys Ile Arg Glu His Asn Arg Ile Cys Asp Val Leu Ser Lys 
            260                 265                 270         


Ser Tyr Pro Glu Trp Asp Asp Glu Arg Leu Phe Gln Thr Ala Arg Asn 
        275                 280                 285             


Ile Leu Met Val Ile Val Leu Asn Ile Ile Met Glu Glu Tyr Ile Phe 
    290                 295                 300                 


His Ile Thr Pro Tyr Asn Phe Arg Phe Phe Ala Asp Pro Glu Ala Phe 
305                 310                 315                 320 


Thr Lys Glu Ser Trp Tyr Arg Glu Asn Trp Met Ala Ile Glu Phe Ser 
                325                 330                 335     


Phe Val Tyr Arg Trp His Ser Ala Ile Pro Glu Thr Phe Ile Tyr Asp 
            340                 345                 350         


Gly Lys Glu Gln Ser Met Tyr Asp Ser Leu Trp Asn Asn Gln Met Leu 
        355                 360                 365             


Ile Asp Lys Gly Leu Gly Ala Leu Met Glu Glu Thr Cys Ser Gln Pro 
    370                 375                 380                 


Gly Thr Arg Ile Gly Leu Phe Asn Thr Pro Asp Phe Lys Ile Ala Gly 
385                 390                 395                 400 


Thr Pro Tyr Thr Phe Ile Asp Ala Thr Glu Leu Ala Ser Val Lys Leu 
                405                 410                 415     


Gly Arg Gln Ala Gln Leu Ala Ser Tyr Asn Asp Tyr Arg Glu Met Cys 
            420                 425                 430         


Gly Tyr Pro Arg Val Thr Asp Phe Asn Gln Ile Thr Gly Asp Glu Tyr 
        435                 440                 445             


Ala Gln Gln Lys Leu Lys Glu Leu Tyr Gly His Val Asp Lys Ile Glu 
    450                 455                 460                 


Leu Phe Val Gly Leu Tyr Ala Glu Asp Val Arg Lys Asn Ser Ala Ile 
465                 470                 475                 480 


Pro Pro Leu Val Ala Arg Ile Ile Gly Ile Asp Ala Phe Ser Gln Ala 
                485                 490                 495     


Leu Thr Asn Pro Leu Leu Ser Pro Lys Val Phe Asn Lys Glu Thr Phe 
            500                 505                 510         


Ser Glu Val Gly Trp Glu Ile Ile Gln Asn Thr Lys Thr Val Ser Asp 
        515                 520                 525             


Leu Val Asn Arg Asn Val Pro Pro Ser Asp Pro Lys Tyr Lys Val Ser 
    530                 535                 540                 


Phe Glu Leu 
545         


<210>  2
<211>  540
<212>  PRT
<213>  Synechocystis PCC7509

<400>  2

Arg Asp Thr Ser Lys Asp Gly Phe Arg Asn Lys Leu Glu Thr Tyr Ala 
1               5                   10                  15      


Leu Thr His Phe Lys Pro Ile Trp Asn Leu Ile Gln Ser Asn Asp Thr 
            20                  25                  30          


Leu Lys Lys Lys Val Asn Lys Phe Leu Val Asn Asn Ala Ile Tyr Lys 
        35                  40                  45              


Val Pro Thr Arg Pro Tyr Pro Phe Ser Thr Met Ser Pro Tyr Thr Ser 
    50                  55                  60                  


Trp Asp Ser Leu Ser Asp Arg Thr Tyr Ser Gly Leu His Leu Pro Pro 
65                  70                  75                  80  


Leu Asp Trp Gln Pro Leu Thr Asn Glu Asn His Leu Lys Leu Lys Leu 
                85                  90                  95      


Ala Asp Thr Lys Asp Phe Glu Lys Lys Leu Pro Ala Ile Glu Asp Leu 
            100                 105                 110         


Arg Gly Leu Tyr Arg Lys Ser Gly Glu Thr Lys Tyr Ser Pro Lys Ser 
        115                 120                 125             


Thr Leu Ile Phe Pro Tyr Phe Val Gln Trp Phe Thr Asp Ser Phe Leu 
    130                 135                 140                 


Arg Thr Asp Arg His Asn His Arg Lys Asn Thr Ser Asn His Gln Ile 
145                 150                 155                 160 


Asp Leu Cys Thr Val Tyr Gly Leu Asn Ala Lys Ile Thr His Leu Leu 
                165                 170                 175     


Arg Ser Tyr Gln Gly Gly Lys Leu Lys Ser Gln Ile Ile Asn Gly Glu 
            180                 185                 190         


Glu Tyr Pro Pro Phe Tyr Tyr Asp Glu Lys Gly Glu Ala Lys Lys Glu 
        195                 200                 205             


Phe Ile Gly Leu Pro His Gln Leu Asp Asn Asp Gly Asn Pro Lys Ala 
    210                 215                 220                 


Asp Thr Phe Pro Leu Asp Lys Lys Gln Lys Leu Phe Ala Met Gly Val 
225                 230                 235                 240 


Glu Val Glu Arg Ser Asn Val Gln Ile Gly Tyr Val Met Leu Asn Val 
                245                 250                 255     


Leu Ala Leu Arg Glu His Asn Arg Leu Cys Glu Leu Leu Ala Lys Thr 
            260                 265                 270         


Tyr Pro Ser Trp Asp Asp Glu Arg Leu Phe Gln Thr Ala Arg Asn Ile 
        275                 280                 285             


Leu Ile Val Glu Val Leu Arg Ile Val Val Glu Asp Tyr Val Asn His 
    290                 295                 300                 


Ile Thr Pro Tyr His Phe Gln Phe Ile Thr Asp Pro Leu Thr Phe Ser 
305                 310                 315                 320 


Asn Glu Lys Trp Tyr Arg Gln Asn Trp Met Thr Val Glu Phe Thr Leu 
                325                 330                 335     


Val Tyr Arg Trp His Ser Met Leu Pro Asp Thr Leu Ile Tyr Asn Gly 
            340                 345                 350         


Gln Lys Ile Pro Thr Tyr Glu Thr Gln Trp Asn Asn Glu Met Ile Ile 
        355                 360                 365             


Lys Gln Gly Leu Gly Ala Leu Phe Glu Glu Ser Cys Ser Gln Pro Cys 
    370                 375                 380                 


Ala Gln Leu Ser Leu Phe Asn Thr Pro Glu Phe Leu Ile Pro Val Glu 
385                 390                 395                 400 


Leu Ala Ser Val Arg Phe Gly Arg Glu Val Lys Leu Arg Ser Tyr Asn 
                405                 410                 415     


Asp Tyr Arg Gln Leu Cys Lys Tyr Pro Arg Val Thr Asp Phe Asp Gln 
            420                 425                 430         


Ile Ser Ser Asp Lys Asn Ile Gln Lys Glu Leu Gln Arg Leu Tyr Gly 
        435                 440                 445             


His Val Asp Asn Ile Glu Leu Tyr Val Gly Ile Tyr Ala Glu Asp Leu 
    450                 455                 460                 


Arg Glu Asn Ser Ala Leu Pro Ser Leu Val Gly Arg Leu Ile Gly Ile 
465                 470                 475                 480 


Asp Ala Phe Ser Gln Val Leu Thr Asn Pro Leu Leu Ala Glu Ser Val 
                485                 490                 495     


Phe His Pro Glu Thr Phe Ser Pro Val Gly Trp Glu Glu Ile Gln Asn 
            500                 505                 510         


Thr Lys Thr Leu Ser Gln Leu Leu His Arg Asn Leu Pro Pro Ser Asp 
        515                 520                 525             


Lys Lys Tyr Arg Val Ser Phe Asp Arg Ala Ser Thr 
    530                 535                 540 


<210>  3
<211>  543
<212>  PRT
<213>  Tolypothrix campylonemoides

<400>  3

Ala Gly Lys Arg Asp Thr Ser Lys Asp Gly Phe Asp Asn Lys Val Gln 
1               5                   10                  15      


Thr Phe Leu Leu Thr Asn Phe Lys Gly Ile Trp Glu Ile Val Gln Ser 
            20                  25                  30          


Asn Glu Phe Leu Lys Arg Lys Val Asn Lys Thr Leu Ile Asn Ser Leu 
        35                  40                  45              


Ile Tyr Lys Ile Pro Thr Arg Pro Asn Pro Tyr Ser Met Met Thr Leu 
    50                  55                  60                  


Asp Glu Tyr Ile Pro Asp Thr Lys Ile Pro Lys Lys Thr Asp Thr Tyr 
65                  70                  75                  80  


Thr Ser Trp Glu Leu Leu Asn Asp Arg Thr Tyr Ile Gly Arg His Leu 
                85                  90                  95      


Pro Pro Asp Pro Lys Phe Asn Ser Glu Gly Asn Leu Pro Lys Val Glu 
            100                 105                 110         


Asp Leu Ala Val Leu Phe Arg Lys Arg Asp Gly Lys Thr Ile Tyr Ser 
        115                 120                 125             


Pro Lys Ser Thr Met Leu Phe Pro Tyr Trp Val Gln Trp Phe Thr Asp 
    130                 135                 140                 


Ser Phe Leu Arg Ile Asp His Thr Lys Glu Lys Lys Leu Lys Asn Thr 
145                 150                 155                 160 


Ser Asn His Glu Ile Asp Leu Cys Asn Val Tyr Gly Leu Asn Arg Lys 
                165                 170                 175     


Arg Thr His Leu Leu Arg Thr Phe Lys Gly Gly Lys Phe Lys Thr Gln 
            180                 185                 190         


Lys Leu Lys Arg Gln Asp Gly Ile Glu Glu Glu Tyr Pro Leu Phe Tyr 
        195                 200                 205             


Tyr Ala Asp Pro Ala Gln Gly Ile Val Asp Pro Gln Phe Asp Gly Leu 
    210                 215                 220                 


Tyr Glu Pro Ile Asn Asp Glu Lys Arg Leu Pro Ala Asp Lys Lys Gln 
225                 230                 235                 240 


Tyr Leu Phe Ala Met Gly Val Glu Arg Ala Asn Val Gln Ile Gly Tyr 
                245                 250                 255     


Val Met Leu Asn Thr Leu Cys Ile Arg Glu His Asn Arg Leu Cys Asp 
            260                 265                 270         


Glu Leu Ala Ser Asn Tyr Pro Asp Trp Asp Asp Glu Arg Leu Phe Gln 
        275                 280                 285             


Thr Ser Arg Asn Ile Leu Met Ala Ile Ile Leu Asn Ile Ile Met Glu 
    290                 295                 300                 


Glu Tyr Ile Asn His Ile Thr Pro Tyr His Phe Lys Leu Phe Ala Asp 
305                 310                 315                 320 


Pro Ala Ala Phe Val Lys Glu Ser Trp Tyr Arg Pro Asn Trp Met Thr 
                325                 330                 335     


Ile Glu Phe Asp Phe Val Tyr Arg Trp His Ser Ala Ile Pro Glu Thr 
            340                 345                 350         


Phe Ile Tyr Asp Gly Gln Pro Thr Asp Ile Ala Ala Ser Leu Trp Asn 
        355                 360                 365             


Asn Lys Met Phe Ile Asp Lys Gly Leu Gly Ala Leu Met Glu Glu Thr 
    370                 375                 380                 


Cys Ser Gln Pro Gly Thr Arg Ile Gly Leu Phe Asn Thr Pro Asp Ile 
385                 390                 395                 400 


Leu Val Glu Leu Thr Glu Leu Pro Ser Ile Arg Leu Gly Arg Gln Leu 
                405                 410                 415     


Gln Leu Ala Ser Tyr Asn Asp Tyr Arg Glu Met Cys Gly Phe Pro Arg 
            420                 425                 430         


Val Thr Lys Phe Glu Gln Ile Thr Gly Asp Glu Phe Ala Gln Glu Lys 
        435                 440                 445             


Leu Lys Glu Leu Tyr Gly His Val Asp Asn Ile Glu Phe Tyr Val Gly 
    450                 455                 460                 


Leu Tyr Ala Glu Glu Val Arg Lys Asn Ser Thr Ile Pro Pro Leu Val 
465                 470                 475                 480 


Ala Arg Leu Ile Gly Ile Asp Ala Phe Ser Glu Ala Leu Asn Asn Pro 
                485                 490                 495     


Leu Leu Ser Pro Thr Ile Phe Asn Lys Asp Thr Phe Ser Pro Val Gly 
            500                 505                 510         


Trp Glu Ile Ile Gln Asn Thr Lys Thr Val Ser Asp Leu Ile Asn Arg 
        515                 520                 525             


Asn Val Pro Pro Ser Asp Lys Lys Tyr Lys Val Thr Phe Asp Leu 
    530                 535                 540             


<210>  4
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered prostaglandin endoperoxide synthase

<400>  4

Thr Arg Asp Thr Ser Arg Asp Gly Phe Ser Asn Lys Ala Leu Ala Tyr 
1               5                   10                  15      


Thr Leu Thr His Phe Lys Pro Ile Trp Asn Leu Val Gln Ser Tyr Glu 
            20                  25                  30          


Pro Leu Lys Arg Lys Leu Asn Lys Phe Phe Leu Asn Ser Ile Ile Tyr 
        35                  40                  45              


Lys Leu Pro Thr Arg Pro Leu Pro Tyr Ser Leu Met Gly Leu Asp Pro 
    50                  55                  60                  


Lys Ile Pro Gly Thr Asp Ile Pro Lys Lys Thr Asp Thr Tyr Ile Ser 
65                  70                  75                  80  


Trp Asp Ser Leu Thr Asp Lys Thr Tyr Thr Gly Arg His Leu Pro Pro 
                85                  90                  95      


Asp Pro Glu Phe Asn Lys Glu Gly Asn Leu Pro Pro Leu Asp Lys Val 
            100                 105                 110         


Lys Thr Leu Phe Gln Lys Arg Asp Gly Lys Thr Ile Tyr Ser Glu Lys 
        115                 120                 125             


Ser Thr Leu Leu Phe Pro Tyr Trp Val Gln Trp Phe Thr Asp Ser Phe 
    130                 135                 140                 


Leu Arg Ile Asp Gln Glu Asn Arg Phe Lys Asn Thr Ser Asn His Gln 
145                 150                 155                 160 


Ile Asp Met Cys Asn Val Tyr Gly Leu Thr Arg Lys Gln Thr Asn Met 
                165                 170                 175     


Leu Arg Ala Phe Lys Asp Gly Lys Phe Lys Thr Gln Lys Leu Lys Arg 
            180                 185                 190         


Lys Asp Gly Val Glu Glu Glu Tyr Pro Leu Phe Tyr Tyr Ala Asp Pro 
        195                 200                 205             


Glu Gln Gly Ile Ile Asp Pro Gln Phe Glu Gly Leu His Ala Pro Leu 
    210                 215                 220                 


Asn Asp Glu Lys Arg Gln Pro Pro Glu Lys Lys Ser Lys Leu Phe Ala 
225                 230                 235                 240 


Met Gly Val Glu Arg Ala Asn Val Gln Ile Gly Tyr Val Met Leu Asn 
                245                 250                 255     


Thr Leu Cys Ile Arg Glu His Asn Arg Ile Cys Asp Val Leu Ser Lys 
            260                 265                 270         


Ser Tyr Pro Glu Trp Asp Asp Glu Arg Leu Phe Gln Thr Ala Arg Asn 
        275                 280                 285             


Ile Leu Met Val Ile Val Leu Asn Ile Ile Met Glu Glu Tyr Ile Phe 
    290                 295                 300                 


His Ile Thr Pro Tyr Asn Phe Arg Phe Phe Ala Asp Pro Glu Ala Phe 
305                 310                 315                 320 


Thr Lys Glu Ser Trp Tyr Arg Glu Asn Trp Met Ala Ile Glu Phe Ser 
                325                 330                 335     


Phe Val Tyr Arg Trp His Ser Ala Ile Pro Glu Thr Phe Ile Tyr Asp 
            340                 345                 350         


Gly Lys Glu Gln Ser Met Tyr Asp Ser Leu Trp Asn Asn Gln Met Leu 
        355                 360                 365             


Ile Asp Lys Gly Leu Gly Ala Leu Met Glu Glu Thr Cys Ser Gln Pro 
    370                 375                 380                 


Gly Thr Arg Ile Gly Leu Phe Asn Thr Pro Asp Phe Lys Ile Ala Gly 
385                 390                 395                 400 


Thr Pro Tyr Thr Phe Ile Asp Ala Thr Glu Leu Ala Ser Val Lys Leu 
                405                 410                 415     


Gly Arg Gln Ala Gln Leu Ala Ser Tyr Asn Asp Tyr Arg Glu Met Cys 
            420                 425                 430         


Gly Tyr Pro Arg Val Thr Asp Phe Asn Gln Ile Thr Gly Asp Glu Tyr 
        435                 440                 445             


Ala Gln Gln Lys Leu Lys Glu Leu Tyr Gly His Val Asp Lys Ile Glu 
    450                 455                 460                 


Leu Phe Val Gly Leu Tyr Ala Glu Asp Val Arg Lys Asn Ser Ala Ile 
465                 470                 475                 480 


Pro Pro Leu Val Ala Arg Ile Ile Gly Ile Asp Ala Phe Ser Gln Ala 
                485                 490                 495     


Leu Thr Asn Pro Leu Leu Ser Pro Lys Val Phe Asn Lys Glu Thr Phe 
            500                 505                 510         


Ser Glu Val Gly Trp Glu Ile Ile Gln Asn Thr Lys Thr Val Ser Asp 
        515                 520                 525             


Leu Val Asn Arg Asn Val Pro Pro Ser Asp Pro Lys Tyr Lys Val Ser 
    530                 535                 540                 


Phe Glu Glu 
545         


<210>  5
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered heme peroxidase

<400>  5

Arg Asp Thr Ser Lys Asp Gly Phe Arg Asn Lys Leu Glu Thr Tyr Ala 
1               5                   10                  15      


Leu Thr His Phe Lys Pro Ile Trp Asn Leu Ile Gln Ser Asn Asp Thr 
            20                  25                  30          


Leu Lys Lys Lys Val Asn Lys Phe Leu Val Asn Asn Ala Ile Tyr Lys 
        35                  40                  45              


Val Pro Thr Arg Pro Tyr Pro Phe Ser Thr Met Ser Pro Tyr Thr Ser 
    50                  55                  60                  


Trp Asp Ser Leu Ser Asp Arg Thr Tyr Ser Gly Leu His Leu Pro Pro 
65                  70                  75                  80  


Leu Asp Trp Gln Pro Leu Thr Asn Glu Asn His Leu Lys Leu Lys Leu 
                85                  90                  95      


Ala Asp Thr Lys Asp Phe Glu Lys Lys Leu Pro Ala Ile Glu Asp Leu 
            100                 105                 110         


Arg Gly Leu Tyr Arg Lys Ser Gly Glu Thr Lys Tyr Ser Pro Lys Ser 
        115                 120                 125             


Thr Leu Ile Phe Pro Tyr Phe Val Gln Trp Phe Thr Asp Ser Phe Leu 
    130                 135                 140                 


Arg Thr Asp Arg His Asn His Arg Lys Asn Thr Ser Asn His Gln Ile 
145                 150                 155                 160 


Asp Leu Cys Thr Val Tyr Gly Leu Asn Ala Lys Ile Thr His Leu Leu 
                165                 170                 175     


Arg Ser Tyr Gln Gly Gly Lys Leu Lys Ser Gln Ile Ile Asn Gly Glu 
            180                 185                 190         


Glu Tyr Pro Pro Phe Tyr Tyr Asp Glu Lys Gly Glu Ala Lys Lys Glu 
        195                 200                 205             


Phe Ile Gly Leu Pro His Gln Leu Asp Asn Asp Gly Asn Pro Lys Ala 
    210                 215                 220                 


Asp Thr Phe Pro Leu Asp Lys Lys Gln Lys Leu Phe Ala Met Gly Val 
225                 230                 235                 240 


Glu Val Glu Arg Ser Asn Val Gln Ile Gly Tyr Val Met Leu Asn Val 
                245                 250                 255     


Leu Ala Leu Arg Glu His Asn Arg Leu Cys Glu Leu Leu Ala Lys Thr 
            260                 265                 270         


Tyr Pro Ser Trp Asp Asp Glu Arg Leu Phe Gln Thr Ala Arg Asn Ile 
        275                 280                 285             


Leu Ile Val Glu Val Leu Arg Ile Val Val Glu Asp Tyr Val Asn His 
    290                 295                 300                 


Ile Thr Pro Tyr His Phe Gln Phe Ile Thr Asp Pro Leu Thr Phe Ser 
305                 310                 315                 320 


Asn Glu Lys Trp Tyr Arg Gln Asn Trp Met Thr Val Glu Phe Thr Leu 
                325                 330                 335     


Val Tyr Arg Trp His Ser Met Leu Pro Asp Thr Leu Ile Tyr Asn Gly 
            340                 345                 350         


Gln Lys Ile Pro Thr Tyr Glu Thr Gln Trp Asn Asn Glu Met Ile Ile 
        355                 360                 365             


Lys Gln Gly Leu Gly Ala Leu Phe Glu Glu Ser Cys Ser Gln Pro Cys 
    370                 375                 380                 


Ala Gln Leu Ser Leu Phe Asn Thr Pro Glu Phe Leu Ile Pro Val Glu 
385                 390                 395                 400 


Leu Ala Ser Val Arg Phe Gly Arg Glu Val Lys Leu Arg Ser Tyr Asn 
                405                 410                 415     


Asp Tyr Arg Gln Leu Cys Lys Tyr Pro Arg Val Thr Asp Phe Asp Gln 
            420                 425                 430         


Ile Ser Ser Asp Lys Asn Ile Gln Lys Glu Leu Gln Arg Leu Tyr Gly 
        435                 440                 445             


His Val Asp Asn Ile Glu Leu Tyr Val Gly Ile Tyr Ala Glu Asp Leu 
    450                 455                 460                 


Arg Glu Asn Ser Ala Leu Pro Ser Leu Val Gly Arg Leu Ile Gly Ile 
465                 470                 475                 480 


Asp Ala Phe Ser Gln Val Leu Thr Asn Pro Leu Leu Ala Glu Ser Val 
                485                 490                 495     


Phe His Pro Glu Thr Phe Ser Pro Val Gly Trp Glu Glu Ile Gln Asn 
            500                 505                 510         


Thr Lys Thr Leu Ser Gln Leu Leu His Arg Asn Leu Pro Pro Ser Asp 
        515                 520                 525             


Lys Lys Tyr Arg Val Ser Phe Asp Arg Ala Ser Glu 
    530                 535                 540 


<210>  6
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered heme peroxidase

<400>  6

Ala Gly Lys Arg Asp Thr Ser Lys Asp Gly Phe Asp Asn Lys Val Gln 
1               5                   10                  15      


Thr Phe Leu Leu Thr Asn Phe Lys Gly Ile Trp Glu Ile Val Gln Ser 
            20                  25                  30          


Asn Glu Phe Leu Lys Arg Lys Val Asn Lys Thr Leu Ile Asn Ser Leu 
        35                  40                  45              


Ile Tyr Lys Ile Pro Thr Arg Pro Asn Pro Tyr Ser Met Met Thr Leu 
    50                  55                  60                  


Asp Glu Tyr Ile Pro Asp Thr Lys Ile Pro Lys Lys Thr Asp Thr Tyr 
65                  70                  75                  80  


Thr Ser Trp Glu Leu Leu Asn Asp Arg Thr Tyr Ile Gly Arg His Leu 
                85                  90                  95      


Pro Pro Asp Pro Lys Phe Asn Ser Glu Gly Asn Leu Pro Lys Val Glu 
            100                 105                 110         


Asp Leu Ala Val Leu Phe Arg Lys Arg Asp Gly Lys Thr Ile Tyr Ser 
        115                 120                 125             


Pro Lys Ser Thr Met Leu Phe Pro Tyr Trp Val Gln Trp Phe Thr Asp 
    130                 135                 140                 


Ser Phe Leu Arg Ile Asp His Thr Lys Glu Lys Lys Leu Lys Asn Thr 
145                 150                 155                 160 


Ser Asn His Glu Ile Asp Leu Cys Asn Val Tyr Gly Leu Asn Arg Lys 
                165                 170                 175     


Arg Thr His Leu Leu Arg Thr Phe Lys Gly Gly Lys Phe Lys Thr Gln 
            180                 185                 190         


Lys Leu Lys Arg Gln Asp Gly Ile Glu Glu Glu Tyr Pro Leu Phe Tyr 
        195                 200                 205             


Tyr Ala Asp Pro Ala Gln Gly Ile Val Asp Pro Gln Phe Asp Gly Leu 
    210                 215                 220                 


Tyr Glu Pro Ile Asn Asp Glu Lys Arg Leu Pro Ala Asp Lys Lys Gln 
225                 230                 235                 240 


Tyr Leu Phe Ala Met Gly Val Glu Arg Ala Asn Val Gln Ile Gly Tyr 
                245                 250                 255     


Val Met Leu Asn Thr Leu Cys Ile Arg Glu His Asn Arg Leu Cys Asp 
            260                 265                 270         


Glu Leu Ala Ser Asn Tyr Pro Asp Trp Asp Asp Glu Arg Leu Phe Gln 
        275                 280                 285             


Thr Ser Arg Asn Ile Leu Met Ala Ile Ile Leu Asn Ile Ile Met Glu 
    290                 295                 300                 


Glu Tyr Ile Asn His Ile Thr Pro Tyr His Phe Lys Leu Phe Ala Asp 
305                 310                 315                 320 


Pro Ala Ala Phe Val Lys Glu Ser Trp Tyr Arg Pro Asn Trp Met Thr 
                325                 330                 335     


Ile Glu Phe Asp Phe Val Tyr Arg Trp His Ser Ala Ile Pro Glu Thr 
            340                 345                 350         


Phe Ile Tyr Asp Gly Gln Pro Thr Asp Ile Ala Ala Ser Leu Trp Asn 
        355                 360                 365             


Asn Lys Met Phe Ile Asp Lys Gly Leu Gly Ala Leu Met Glu Glu Thr 
    370                 375                 380                 


Cys Ser Gln Pro Gly Thr Arg Ile Gly Leu Phe Asn Thr Pro Asp Ile 
385                 390                 395                 400 


Leu Val Glu Leu Thr Glu Leu Pro Ser Ile Arg Leu Gly Arg Gln Leu 
                405                 410                 415     


Gln Leu Ala Ser Tyr Asn Asp Tyr Arg Glu Met Cys Gly Phe Pro Arg 
            420                 425                 430         


Val Thr Lys Phe Glu Gln Ile Thr Gly Asp Glu Phe Ala Gln Glu Lys 
        435                 440                 445             


Leu Lys Glu Leu Tyr Gly His Val Asp Asn Ile Glu Phe Tyr Val Gly 
    450                 455                 460                 


Leu Tyr Ala Glu Glu Val Arg Lys Asn Ser Thr Ile Pro Pro Leu Val 
465                 470                 475                 480 


Ala Arg Leu Ile Gly Ile Asp Ala Phe Ser Glu Ala Leu Asn Asn Pro 
                485                 490                 495     


Leu Leu Ser Pro Thr Ile Phe Asn Lys Asp Thr Phe Ser Pro Val Gly 
            500                 505                 510         


Trp Glu Ile Ile Gln Asn Thr Lys Thr Val Ser Asp Leu Ile Asn Arg 
        515                 520                 525             


Asn Val Pro Pro Ser Asp Lys Lys Tyr Lys Val Thr Phe Asp Glu 
    530                 535                 540             


<210>  7
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered prostaglandin-endoperoxide synthase

<400>  7

Thr Arg Asp Thr Ser Arg Asp Gly Phe Ser Asn Lys Ala Leu Ala Tyr 
1               5                   10                  15      


Thr Leu Thr His Phe Lys Pro Ile Trp Asn Leu Val Gln Ser Tyr Glu 
            20                  25                  30          


Pro Leu Lys Arg Lys Leu Asn Lys Phe Phe Leu Asn Ser Ile Ile Tyr 
        35                  40                  45              


Lys Leu Pro Thr Arg Pro Leu Pro Tyr Ser Leu Met Gly Leu Asp Pro 
    50                  55                  60                  


Lys Ile Pro Gly Thr Asp Ile Pro Lys Lys Thr Asp Thr Tyr Ile Ser 
65                  70                  75                  80  


Trp Asp Ser Leu Thr Asp Lys Thr Tyr Thr Gly Arg His Leu Pro Pro 
                85                  90                  95      


Asp Pro Glu Phe Asn Lys Glu Gly Asn Leu Pro Pro Leu Asp Lys Val 
            100                 105                 110         


Lys Thr Leu Phe Gln Lys Arg Asp Gly Lys Thr Ile Tyr Ser Glu Lys 
        115                 120                 125             


Ser Thr Leu Leu Phe Pro Tyr Trp Val Gln Trp Phe Thr Asp Ser Phe 
    130                 135                 140                 


Leu Arg Ile Asp Gln Glu Asn Arg Phe Lys Asn Thr Ser Asn His Gln 
145                 150                 155                 160 


Ile Asp Met Cys Asn Val Tyr Gly Leu Thr Arg Lys Gln Thr Asn Met 
                165                 170                 175     


Leu Arg Ala Phe Lys Asp Gly Lys Phe Lys Thr Gln Lys Leu Lys Arg 
            180                 185                 190         


Lys Asp Gly Val Glu Glu Glu Tyr Pro Leu Phe Tyr Tyr Ala Asp Pro 
        195                 200                 205             


Glu Gln Gly Ile Ile Asp Pro Gln Phe Glu Gly Leu His Ala Pro Leu 
    210                 215                 220                 


Asn Asp Glu Lys Arg Gln Pro Pro Glu Lys Lys Ser Lys Leu Phe Ala 
225                 230                 235                 240 


Met Gly Val Glu Arg Ala Asn Val Gln Ile Gly Tyr Val Met Leu Asn 
                245                 250                 255     


Thr Leu Cys Ile Arg Glu His Asn Arg Ile Cys Asp Val Leu Ser Lys 
            260                 265                 270         


Ser Tyr Pro Glu Trp Asp Asp Glu Arg Leu Phe Gln Thr Ala Arg Asn 
        275                 280                 285             


Ile Leu Met Val Ile Val Leu Asn Ile Ile Met Glu Glu Tyr Ile Phe 
    290                 295                 300                 


His Ile Thr Pro Tyr Asn Phe Arg Phe Phe Ala Asp Pro Glu Ala Phe 
305                 310                 315                 320 


Thr Lys Glu Ser Trp Tyr Arg Glu Asn Trp Met Ala Ile Glu Phe Ser 
                325                 330                 335     


Phe Val Tyr Arg Trp His Ser Ala Ile Pro Glu Thr Phe Ile Tyr Asp 
            340                 345                 350         


Gly Lys Glu Gln Ser Met Tyr Asp Ser Leu Trp Asn Asn Gln Met Leu 
        355                 360                 365             


Ile Asp Lys Gly Leu Gly Ala Leu Met Glu Glu Thr Cys Ser Gln Pro 
    370                 375                 380                 


Gly Thr Arg Ile Gly Leu Phe Asn Thr Pro Asp Phe Lys Ile Ala Gly 
385                 390                 395                 400 


Thr Pro Tyr Thr Phe Ile Asp Ala Thr Glu Leu Ala Ser Val Lys Leu 
                405                 410                 415     


Gly Arg Gln Ala Gln Leu Ala Ser Tyr Asn Asp Tyr Arg Glu Met Cys 
            420                 425                 430         


Gly Tyr Pro Arg Val Thr Asp Phe Asn Gln Ile Thr Gly Asp Glu Tyr 
        435                 440                 445             


Ala Gln Gln Lys Leu Lys Glu Leu Tyr Gly His Val Asp Lys Ile Glu 
    450                 455                 460                 


Leu Phe Val Gly Leu Tyr Ala Glu Asp Val Arg Lys Asn Ser Ala Ile 
465                 470                 475                 480 


Pro Pro Leu Val Ala Arg Ile Ile Gly Ile Asp Ala Phe Ser Gln Ala 
                485                 490                 495     


Leu Thr Asn Pro Leu Leu Ser Pro Lys Val Phe Asn Lys Glu Thr Phe 
            500                 505                 510         


Ser Glu Val Gly Trp Glu Ile Ile Gln Asn Thr Lys Thr Val Ser Asp 
        515                 520                 525             


Leu Val Asn Arg Asn Val Pro Pro Ser Asp Pro Lys Tyr Lys Val Ser 
    530                 535                 540                 


Phe Glu Asp 
545         


<210>  8
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered heme peroxidase

<400>  8

Arg Asp Thr Ser Lys Asp Gly Phe Arg Asn Lys Leu Glu Thr Tyr Ala 
1               5                   10                  15      


Leu Thr His Phe Lys Pro Ile Trp Asn Leu Ile Gln Ser Asn Asp Thr 
            20                  25                  30          


Leu Lys Lys Lys Val Asn Lys Phe Leu Val Asn Asn Ala Ile Tyr Lys 
        35                  40                  45              


Val Pro Thr Arg Pro Tyr Pro Phe Ser Thr Met Ser Pro Tyr Thr Ser 
    50                  55                  60                  


Trp Asp Ser Leu Ser Asp Arg Thr Tyr Ser Gly Leu His Leu Pro Pro 
65                  70                  75                  80  


Leu Asp Trp Gln Pro Leu Thr Asn Glu Asn His Leu Lys Leu Lys Leu 
                85                  90                  95      


Ala Asp Thr Lys Asp Phe Glu Lys Lys Leu Pro Ala Ile Glu Asp Leu 
            100                 105                 110         


Arg Gly Leu Tyr Arg Lys Ser Gly Glu Thr Lys Tyr Ser Pro Lys Ser 
        115                 120                 125             


Thr Leu Ile Phe Pro Tyr Phe Val Gln Trp Phe Thr Asp Ser Phe Leu 
    130                 135                 140                 


Arg Thr Asp Arg His Asn His Arg Lys Asn Thr Ser Asn His Gln Ile 
145                 150                 155                 160 


Asp Leu Cys Thr Val Tyr Gly Leu Asn Ala Lys Ile Thr His Leu Leu 
                165                 170                 175     


Arg Ser Tyr Gln Gly Gly Lys Leu Lys Ser Gln Ile Ile Asn Gly Glu 
            180                 185                 190         


Glu Tyr Pro Pro Phe Tyr Tyr Asp Glu Lys Gly Glu Ala Lys Lys Glu 
        195                 200                 205             


Phe Ile Gly Leu Pro His Gln Leu Asp Asn Asp Gly Asn Pro Lys Ala 
    210                 215                 220                 


Asp Thr Phe Pro Leu Asp Lys Lys Gln Lys Leu Phe Ala Met Gly Val 
225                 230                 235                 240 


Glu Val Glu Arg Ser Asn Val Gln Ile Gly Tyr Val Met Leu Asn Val 
                245                 250                 255     


Leu Ala Leu Arg Glu His Asn Arg Leu Cys Glu Leu Leu Ala Lys Thr 
            260                 265                 270         


Tyr Pro Ser Trp Asp Asp Glu Arg Leu Phe Gln Thr Ala Arg Asn Ile 
        275                 280                 285             


Leu Ile Val Glu Val Leu Arg Ile Val Val Glu Asp Tyr Val Asn His 
    290                 295                 300                 


Ile Thr Pro Tyr His Phe Gln Phe Ile Thr Asp Pro Leu Thr Phe Ser 
305                 310                 315                 320 


Asn Glu Lys Trp Tyr Arg Gln Asn Trp Met Thr Val Glu Phe Thr Leu 
                325                 330                 335     


Val Tyr Arg Trp His Ser Met Leu Pro Asp Thr Leu Ile Tyr Asn Gly 
            340                 345                 350         


Gln Lys Ile Pro Thr Tyr Glu Thr Gln Trp Asn Asn Glu Met Ile Ile 
        355                 360                 365             


Lys Gln Gly Leu Gly Ala Leu Phe Glu Glu Ser Cys Ser Gln Pro Cys 
    370                 375                 380                 


Ala Gln Leu Ser Leu Phe Asn Thr Pro Glu Phe Leu Ile Pro Val Glu 
385                 390                 395                 400 


Leu Ala Ser Val Arg Phe Gly Arg Glu Val Lys Leu Arg Ser Tyr Asn 
                405                 410                 415     


Asp Tyr Arg Gln Leu Cys Lys Tyr Pro Arg Val Thr Asp Phe Asp Gln 
            420                 425                 430         


Ile Ser Ser Asp Lys Asn Ile Gln Lys Glu Leu Gln Arg Leu Tyr Gly 
        435                 440                 445             


His Val Asp Asn Ile Glu Leu Tyr Val Gly Ile Tyr Ala Glu Asp Leu 
    450                 455                 460                 


Arg Glu Asn Ser Ala Leu Pro Ser Leu Val Gly Arg Leu Ile Gly Ile 
465                 470                 475                 480 


Asp Ala Phe Ser Gln Val Leu Thr Asn Pro Leu Leu Ala Glu Ser Val 
                485                 490                 495     


Phe His Pro Glu Thr Phe Ser Pro Val Gly Trp Glu Glu Ile Gln Asn 
            500                 505                 510         


Thr Lys Thr Leu Ser Gln Leu Leu His Arg Asn Leu Pro Pro Ser Asp 
        515                 520                 525             


Lys Lys Tyr Arg Val Ser Phe Asp Arg Ala Ser Asp 
    530                 535                 540 


<210>  9
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered heme peroxidase

<400>  9

Ala Gly Lys Arg Asp Thr Ser Lys Asp Gly Phe Asp Asn Lys Val Gln 
1               5                   10                  15      


Thr Phe Leu Leu Thr Asn Phe Lys Gly Ile Trp Glu Ile Val Gln Ser 
            20                  25                  30          


Asn Glu Phe Leu Lys Arg Lys Val Asn Lys Thr Leu Ile Asn Ser Leu 
        35                  40                  45              


Ile Tyr Lys Ile Pro Thr Arg Pro Asn Pro Tyr Ser Met Met Thr Leu 
    50                  55                  60                  


Asp Glu Tyr Ile Pro Asp Thr Lys Ile Pro Lys Lys Thr Asp Thr Tyr 
65                  70                  75                  80  


Thr Ser Trp Glu Leu Leu Asn Asp Arg Thr Tyr Ile Gly Arg His Leu 
                85                  90                  95      


Pro Pro Asp Pro Lys Phe Asn Ser Glu Gly Asn Leu Pro Lys Val Glu 
            100                 105                 110         


Asp Leu Ala Val Leu Phe Arg Lys Arg Asp Gly Lys Thr Ile Tyr Ser 
        115                 120                 125             


Pro Lys Ser Thr Met Leu Phe Pro Tyr Trp Val Gln Trp Phe Thr Asp 
    130                 135                 140                 


Ser Phe Leu Arg Ile Asp His Thr Lys Glu Lys Lys Leu Lys Asn Thr 
145                 150                 155                 160 


Ser Asn His Glu Ile Asp Leu Cys Asn Val Tyr Gly Leu Asn Arg Lys 
                165                 170                 175     


Arg Thr His Leu Leu Arg Thr Phe Lys Gly Gly Lys Phe Lys Thr Gln 
            180                 185                 190         


Lys Leu Lys Arg Gln Asp Gly Ile Glu Glu Glu Tyr Pro Leu Phe Tyr 
        195                 200                 205             


Tyr Ala Asp Pro Ala Gln Gly Ile Val Asp Pro Gln Phe Asp Gly Leu 
    210                 215                 220                 


Tyr Glu Pro Ile Asn Asp Glu Lys Arg Leu Pro Ala Asp Lys Lys Gln 
225                 230                 235                 240 


Tyr Leu Phe Ala Met Gly Val Glu Arg Ala Asn Val Gln Ile Gly Tyr 
                245                 250                 255     


Val Met Leu Asn Thr Leu Cys Ile Arg Glu His Asn Arg Leu Cys Asp 
            260                 265                 270         


Glu Leu Ala Ser Asn Tyr Pro Asp Trp Asp Asp Glu Arg Leu Phe Gln 
        275                 280                 285             


Thr Ser Arg Asn Ile Leu Met Ala Ile Ile Leu Asn Ile Ile Met Glu 
    290                 295                 300                 


Glu Tyr Ile Asn His Ile Thr Pro Tyr His Phe Lys Leu Phe Ala Asp 
305                 310                 315                 320 


Pro Ala Ala Phe Val Lys Glu Ser Trp Tyr Arg Pro Asn Trp Met Thr 
                325                 330                 335     


Ile Glu Phe Asp Phe Val Tyr Arg Trp His Ser Ala Ile Pro Glu Thr 
            340                 345                 350         


Phe Ile Tyr Asp Gly Gln Pro Thr Asp Ile Ala Ala Ser Leu Trp Asn 
        355                 360                 365             


Asn Lys Met Phe Ile Asp Lys Gly Leu Gly Ala Leu Met Glu Glu Thr 
    370                 375                 380                 


Cys Ser Gln Pro Gly Thr Arg Ile Gly Leu Phe Asn Thr Pro Asp Ile 
385                 390                 395                 400 


Leu Val Glu Leu Thr Glu Leu Pro Ser Ile Arg Leu Gly Arg Gln Leu 
                405                 410                 415     


Gln Leu Ala Ser Tyr Asn Asp Tyr Arg Glu Met Cys Gly Phe Pro Arg 
            420                 425                 430         


Val Thr Lys Phe Glu Gln Ile Thr Gly Asp Glu Phe Ala Gln Glu Lys 
        435                 440                 445             


Leu Lys Glu Leu Tyr Gly His Val Asp Asn Ile Glu Phe Tyr Val Gly 
    450                 455                 460                 


Leu Tyr Ala Glu Glu Val Arg Lys Asn Ser Thr Ile Pro Pro Leu Val 
465                 470                 475                 480 


Ala Arg Leu Ile Gly Ile Asp Ala Phe Ser Glu Ala Leu Asn Asn Pro 
                485                 490                 495     


Leu Leu Ser Pro Thr Ile Phe Asn Lys Asp Thr Phe Ser Pro Val Gly 
            500                 505                 510         


Trp Glu Ile Ile Gln Asn Thr Lys Thr Val Ser Asp Leu Ile Asn Arg 
        515                 520                 525             


Asn Val Pro Pro Ser Asp Lys Lys Tyr Lys Val Thr Phe Asp Asp 
    530                 535                 540             


<210>  10
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered prostaglandin-endoperoxide synthase

<400>  10

Thr Arg Asp Thr Ser Arg Asp Gly Phe Ser Asn Lys Ala Leu Ala Tyr 
1               5                   10                  15      


Thr Leu Thr His Phe Lys Pro Ile Trp Asn Leu Val Gln Ser Tyr Glu 
            20                  25                  30          


Pro Leu Lys Arg Lys Leu Asn Lys Phe Phe Leu Asn Ser Ile Ile Tyr 
        35                  40                  45              


Lys Leu Pro Thr Arg Pro Leu Pro Tyr Ser Leu Met Gly Leu Asp Pro 
    50                  55                  60                  


Lys Ile Pro Gly Thr Asp Ile Pro Lys Lys Thr Asp Thr Tyr Ile Ser 
65                  70                  75                  80  


Trp Asp Ser Leu Thr Asp Lys Thr Tyr Thr Gly Arg His Leu Pro Pro 
                85                  90                  95      


Asp Pro Glu Phe Asn Lys Glu Gly Asn Leu Pro Pro Leu Asp Lys Val 
            100                 105                 110         


Lys Thr Leu Phe Gln Lys Arg Asp Gly Lys Thr Ile Tyr Ser Glu Lys 
        115                 120                 125             


Ser Thr Leu Leu Phe Pro Tyr Trp Val Gln Trp Phe Thr Asp Ser Phe 
    130                 135                 140                 


Leu Arg Ile Asp Gln Glu Asn Arg Phe Lys Asn Thr Ser Asn His Gln 
145                 150                 155                 160 


Ile Asp Met Cys Asn Val Tyr Gly Leu Thr Arg Lys Gln Thr Asn Met 
                165                 170                 175     


Leu Arg Ala Phe Lys Asp Gly Lys Phe Lys Thr Gln Lys Leu Lys Arg 
            180                 185                 190         


Lys Asp Gly Val Glu Glu Glu Tyr Pro Leu Phe Tyr Tyr Ala Asp Pro 
        195                 200                 205             


Glu Gln Gly Ile Ile Asp Pro Gln Phe Glu Gly Leu His Ala Pro Leu 
    210                 215                 220                 


Asn Asp Glu Lys Arg Gln Pro Pro Glu Lys Lys Ser Lys Leu Phe Ala 
225                 230                 235                 240 


Met Gly Val Glu Arg Ala Asn Val Gln Ile Gly Tyr Val Met Leu Asn 
                245                 250                 255     


Thr Leu Cys Ile Arg Glu His Asn Arg Ile Cys Asp Val Leu Ser Lys 
            260                 265                 270         


Ser Tyr Pro Glu Trp Asp Asp Glu Arg Leu Phe Gln Thr Ala Arg Asn 
        275                 280                 285             


Ile Leu Met Val Ile Val Leu Asn Ile Ile Met Glu Glu Tyr Ile Phe 
    290                 295                 300                 


His Ile Thr Pro Tyr Asn Phe Arg Phe Phe Ala Asp Pro Glu Ala Phe 
305                 310                 315                 320 


Thr Lys Glu Ser Trp Tyr Arg Glu Asn Trp Met Ala Ile Glu Phe Ser 
                325                 330                 335     


Phe Val Tyr Arg Trp His Ser Ala Ile Pro Glu Thr Phe Ile Tyr Asp 
            340                 345                 350         


Gly Lys Glu Gln Ser Met Tyr Asp Ser Leu Trp Asn Asn Gln Met Leu 
        355                 360                 365             


Ile Asp Lys Gly Leu Gly Ala Leu Met Glu Glu Thr Cys Ser Gln Pro 
    370                 375                 380                 


Gly Thr Arg Ile Gly Leu Phe Asn Thr Pro Asp Phe Lys Ile Ala Gly 
385                 390                 395                 400 


Thr Pro Tyr Thr Phe Ile Asp Ala Thr Glu Leu Ala Ser Val Lys Leu 
                405                 410                 415     


Gly Arg Gln Ala Gln Leu Ala Ser Tyr Asn Asp Tyr Arg Glu Met Cys 
            420                 425                 430         


Gly Tyr Pro Arg Val Thr Asp Phe Asn Gln Ile Thr Gly Asp Glu Tyr 
        435                 440                 445             


Ala Gln Gln Lys Leu Lys Glu Leu Tyr Gly His Val Asp Lys Ile Glu 
    450                 455                 460                 


Leu Phe Val Gly Leu Tyr Ala Glu Asp Val Arg Lys Asn Ser Ala Ile 
465                 470                 475                 480 


Pro Pro Leu Val Ala Arg Ile Ile Gly Ile Asp Ala Phe Ser Gln Ala 
                485                 490                 495     


Leu Thr Asn Pro Leu Leu Ser Pro Lys Val Phe Asn Lys Glu Thr Phe 
            500                 505                 510         


Ser Glu Val Gly Trp Glu Ile Ile Gln Asn Thr Lys Thr Val Ser Asp 
        515                 520                 525             


Leu Val Asn Arg Asn Val Pro Pro Ser Asp Pro Lys Tyr Lys Val Ser 
    530                 535                 540                 


Phe Glu Thr 
545         


<210>  11
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered heme peroxidase

<400>  11

Arg Asp Thr Ser Lys Asp Gly Phe Arg Asn Lys Leu Glu Thr Tyr Ala 
1               5                   10                  15      


Leu Thr His Phe Lys Pro Ile Trp Asn Leu Ile Gln Ser Asn Asp Thr 
            20                  25                  30          


Leu Lys Lys Lys Val Asn Lys Phe Leu Val Asn Asn Ala Ile Tyr Lys 
        35                  40                  45              


Val Pro Thr Arg Pro Tyr Pro Phe Ser Thr Met Ser Pro Tyr Thr Ser 
    50                  55                  60                  


Trp Asp Ser Leu Ser Asp Arg Thr Tyr Ser Gly Leu His Leu Pro Pro 
65                  70                  75                  80  


Leu Asp Trp Gln Pro Leu Thr Asn Glu Asn His Leu Lys Leu Lys Leu 
                85                  90                  95      


Ala Asp Thr Lys Asp Phe Glu Lys Lys Leu Pro Ala Ile Glu Asp Leu 
            100                 105                 110         


Arg Gly Leu Tyr Arg Lys Ser Gly Glu Thr Lys Tyr Ser Pro Lys Ser 
        115                 120                 125             


Thr Leu Ile Phe Pro Tyr Phe Val Gln Trp Phe Thr Asp Ser Phe Leu 
    130                 135                 140                 


Arg Thr Asp Arg His Asn His Arg Lys Asn Thr Ser Asn His Gln Ile 
145                 150                 155                 160 


Asp Leu Cys Thr Val Tyr Gly Leu Asn Ala Lys Ile Thr His Leu Leu 
                165                 170                 175     


Arg Ser Tyr Gln Gly Gly Lys Leu Lys Ser Gln Ile Ile Asn Gly Glu 
            180                 185                 190         


Glu Tyr Pro Pro Phe Tyr Tyr Asp Glu Lys Gly Glu Ala Lys Lys Glu 
        195                 200                 205             


Phe Ile Gly Leu Pro His Gln Leu Asp Asn Asp Gly Asn Pro Lys Ala 
    210                 215                 220                 


Asp Thr Phe Pro Leu Asp Lys Lys Gln Lys Leu Phe Ala Met Gly Val 
225                 230                 235                 240 


Glu Val Glu Arg Ser Asn Val Gln Ile Gly Tyr Val Met Leu Asn Val 
                245                 250                 255     


Leu Ala Leu Arg Glu His Asn Arg Leu Cys Glu Leu Leu Ala Lys Thr 
            260                 265                 270         


Tyr Pro Ser Trp Asp Asp Glu Arg Leu Phe Gln Thr Ala Arg Asn Ile 
        275                 280                 285             


Leu Ile Val Glu Val Leu Arg Ile Val Val Glu Asp Tyr Val Asn His 
    290                 295                 300                 


Ile Thr Pro Tyr His Phe Gln Phe Ile Thr Asp Pro Leu Thr Phe Ser 
305                 310                 315                 320 


Asn Glu Lys Trp Tyr Arg Gln Asn Trp Met Thr Val Glu Phe Thr Leu 
                325                 330                 335     


Val Tyr Arg Trp His Ser Met Leu Pro Asp Thr Leu Ile Tyr Asn Gly 
            340                 345                 350         


Gln Lys Ile Pro Thr Tyr Glu Thr Gln Trp Asn Asn Glu Met Ile Ile 
        355                 360                 365             


Lys Gln Gly Leu Gly Ala Leu Phe Glu Glu Ser Cys Ser Gln Pro Cys 
    370                 375                 380                 


Ala Gln Leu Ser Leu Phe Asn Thr Pro Glu Phe Leu Ile Pro Val Glu 
385                 390                 395                 400 


Leu Ala Ser Val Arg Phe Gly Arg Glu Val Lys Leu Arg Ser Tyr Asn 
                405                 410                 415     


Asp Tyr Arg Gln Leu Cys Lys Tyr Pro Arg Val Thr Asp Phe Asp Gln 
            420                 425                 430         


Ile Ser Ser Asp Lys Asn Ile Gln Lys Glu Leu Gln Arg Leu Tyr Gly 
        435                 440                 445             


His Val Asp Asn Ile Glu Leu Tyr Val Gly Ile Tyr Ala Glu Asp Leu 
    450                 455                 460                 


Arg Glu Asn Ser Ala Leu Pro Ser Leu Val Gly Arg Leu Ile Gly Ile 
465                 470                 475                 480 


Asp Ala Phe Ser Gln Val Leu Thr Asn Pro Leu Leu Ala Glu Ser Val 
                485                 490                 495     


Phe His Pro Glu Thr Phe Ser Pro Val Gly Trp Glu Glu Ile Gln Asn 
            500                 505                 510         


Thr Lys Thr Leu Ser Gln Leu Leu His Arg Asn Leu Pro Pro Ser Asp 
        515                 520                 525             


Lys Lys Tyr Arg Val Ser Phe Asp Arg Ala Ser Leu 
    530                 535                 540 


<210>  12
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered heme peroxidase

<400>  12

Ala Gly Lys Arg Asp Thr Ser Lys Asp Gly Phe Asp Asn Lys Val Gln 
1               5                   10                  15      


Thr Phe Leu Leu Thr Asn Phe Lys Gly Ile Trp Glu Ile Val Gln Ser 
            20                  25                  30          


Asn Glu Phe Leu Lys Arg Lys Val Asn Lys Thr Leu Ile Asn Ser Leu 
        35                  40                  45              


Ile Tyr Lys Ile Pro Thr Arg Pro Asn Pro Tyr Ser Met Met Thr Leu 
    50                  55                  60                  


Asp Glu Tyr Ile Pro Asp Thr Lys Ile Pro Lys Lys Thr Asp Thr Tyr 
65                  70                  75                  80  


Thr Ser Trp Glu Leu Leu Asn Asp Arg Thr Tyr Ile Gly Arg His Leu 
                85                  90                  95      


Pro Pro Asp Pro Lys Phe Asn Ser Glu Gly Asn Leu Pro Lys Val Glu 
            100                 105                 110         


Asp Leu Ala Val Leu Phe Arg Lys Arg Asp Gly Lys Thr Ile Tyr Ser 
        115                 120                 125             


Pro Lys Ser Thr Met Leu Phe Pro Tyr Trp Val Gln Trp Phe Thr Asp 
    130                 135                 140                 


Ser Phe Leu Arg Ile Asp His Thr Lys Glu Lys Lys Leu Lys Asn Thr 
145                 150                 155                 160 


Ser Asn His Glu Ile Asp Leu Cys Asn Val Tyr Gly Leu Asn Arg Lys 
                165                 170                 175     


Arg Thr His Leu Leu Arg Thr Phe Lys Gly Gly Lys Phe Lys Thr Gln 
            180                 185                 190         


Lys Leu Lys Arg Gln Asp Gly Ile Glu Glu Glu Tyr Pro Leu Phe Tyr 
        195                 200                 205             


Tyr Ala Asp Pro Ala Gln Gly Ile Val Asp Pro Gln Phe Asp Gly Leu 
    210                 215                 220                 


Tyr Glu Pro Ile Asn Asp Glu Lys Arg Leu Pro Ala Asp Lys Lys Gln 
225                 230                 235                 240 


Tyr Leu Phe Ala Met Gly Val Glu Arg Ala Asn Val Gln Ile Gly Tyr 
                245                 250                 255     


Val Met Leu Asn Thr Leu Cys Ile Arg Glu His Asn Arg Leu Cys Asp 
            260                 265                 270         


Glu Leu Ala Ser Asn Tyr Pro Asp Trp Asp Asp Glu Arg Leu Phe Gln 
        275                 280                 285             


Thr Ser Arg Asn Ile Leu Met Ala Ile Ile Leu Asn Ile Ile Met Glu 
    290                 295                 300                 


Glu Tyr Ile Asn His Ile Thr Pro Tyr His Phe Lys Leu Phe Ala Asp 
305                 310                 315                 320 


Pro Ala Ala Phe Val Lys Glu Ser Trp Tyr Arg Pro Asn Trp Met Thr 
                325                 330                 335     


Ile Glu Phe Asp Phe Val Tyr Arg Trp His Ser Ala Ile Pro Glu Thr 
            340                 345                 350         


Phe Ile Tyr Asp Gly Gln Pro Thr Asp Ile Ala Ala Ser Leu Trp Asn 
        355                 360                 365             


Asn Lys Met Phe Ile Asp Lys Gly Leu Gly Ala Leu Met Glu Glu Thr 
    370                 375                 380                 


Cys Ser Gln Pro Gly Thr Arg Ile Gly Leu Phe Asn Thr Pro Asp Ile 
385                 390                 395                 400 


Leu Val Glu Leu Thr Glu Leu Pro Ser Ile Arg Leu Gly Arg Gln Leu 
                405                 410                 415     


Gln Leu Ala Ser Tyr Asn Asp Tyr Arg Glu Met Cys Gly Phe Pro Arg 
            420                 425                 430         


Val Thr Lys Phe Glu Gln Ile Thr Gly Asp Glu Phe Ala Gln Glu Lys 
        435                 440                 445             


Leu Lys Glu Leu Tyr Gly His Val Asp Asn Ile Glu Phe Tyr Val Gly 
    450                 455                 460                 


Leu Tyr Ala Glu Glu Val Arg Lys Asn Ser Thr Ile Pro Pro Leu Val 
465                 470                 475                 480 


Ala Arg Leu Ile Gly Ile Asp Ala Phe Ser Glu Ala Leu Asn Asn Pro 
                485                 490                 495     


Leu Leu Ser Pro Thr Ile Phe Asn Lys Asp Thr Phe Ser Pro Val Gly 
            500                 505                 510         


Trp Glu Ile Ile Gln Asn Thr Lys Thr Val Ser Asp Leu Ile Asn Arg 
        515                 520                 525             


Asn Val Pro Pro Ser Asp Lys Lys Tyr Lys Val Thr Phe Asp Thr 
    530                 535                 540             


<210>  13
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus prostaglandin-endoperoxide synthase sequence


<220>
<221>  misc_feature
<222>  (547)..(547)
<223>  Xaa can be any naturally occurring amino acid

<400>  13

Thr Arg Asp Thr Ser Arg Asp Gly Phe Ser Asn Lys Ala Leu Ala Tyr 
1               5                   10                  15      


Thr Leu Thr His Phe Lys Pro Ile Trp Asn Leu Val Gln Ser Tyr Glu 
            20                  25                  30          


Pro Leu Lys Arg Lys Leu Asn Lys Phe Phe Leu Asn Ser Ile Ile Tyr 
        35                  40                  45              


Lys Leu Pro Thr Arg Pro Leu Pro Tyr Ser Leu Met Gly Leu Asp Pro 
    50                  55                  60                  


Lys Ile Pro Gly Thr Asp Ile Pro Lys Lys Thr Asp Thr Tyr Ile Ser 
65                  70                  75                  80  


Trp Asp Ser Leu Thr Asp Lys Thr Tyr Thr Gly Arg His Leu Pro Pro 
                85                  90                  95      


Asp Pro Glu Phe Asn Lys Glu Gly Asn Leu Pro Pro Leu Asp Lys Val 
            100                 105                 110         


Lys Thr Leu Phe Gln Lys Arg Asp Gly Lys Thr Ile Tyr Ser Glu Lys 
        115                 120                 125             


Ser Thr Leu Leu Phe Pro Tyr Trp Val Gln Trp Phe Thr Asp Ser Phe 
    130                 135                 140                 


Leu Arg Ile Asp Gln Glu Asn Arg Phe Lys Asn Thr Ser Asn His Gln 
145                 150                 155                 160 


Ile Asp Met Cys Asn Val Tyr Gly Leu Thr Arg Lys Gln Thr Asn Met 
                165                 170                 175     


Leu Arg Ala Phe Lys Asp Gly Lys Phe Lys Thr Gln Lys Leu Lys Arg 
            180                 185                 190         


Lys Asp Gly Val Glu Glu Glu Tyr Pro Leu Phe Tyr Tyr Ala Asp Pro 
        195                 200                 205             


Glu Gln Gly Ile Ile Asp Pro Gln Phe Glu Gly Leu His Ala Pro Leu 
    210                 215                 220                 


Asn Asp Glu Lys Arg Gln Pro Pro Glu Lys Lys Ser Lys Leu Phe Ala 
225                 230                 235                 240 


Met Gly Val Glu Arg Ala Asn Val Gln Ile Gly Tyr Val Met Leu Asn 
                245                 250                 255     


Thr Leu Cys Ile Arg Glu His Asn Arg Ile Cys Asp Val Leu Ser Lys 
            260                 265                 270         


Ser Tyr Pro Glu Trp Asp Asp Glu Arg Leu Phe Gln Thr Ala Arg Asn 
        275                 280                 285             


Ile Leu Met Val Ile Val Leu Asn Ile Ile Met Glu Glu Tyr Ile Phe 
    290                 295                 300                 


His Ile Thr Pro Tyr Asn Phe Arg Phe Phe Ala Asp Pro Glu Ala Phe 
305                 310                 315                 320 


Thr Lys Glu Ser Trp Tyr Arg Glu Asn Trp Met Ala Ile Glu Phe Ser 
                325                 330                 335     


Phe Val Tyr Arg Trp His Ser Ala Ile Pro Glu Thr Phe Ile Tyr Asp 
            340                 345                 350         


Gly Lys Glu Gln Ser Met Tyr Asp Ser Leu Trp Asn Asn Gln Met Leu 
        355                 360                 365             


Ile Asp Lys Gly Leu Gly Ala Leu Met Glu Glu Thr Cys Ser Gln Pro 
    370                 375                 380                 


Gly Thr Arg Ile Gly Leu Phe Asn Thr Pro Asp Phe Lys Ile Ala Gly 
385                 390                 395                 400 


Thr Pro Tyr Thr Phe Ile Asp Ala Thr Glu Leu Ala Ser Val Lys Leu 
                405                 410                 415     


Gly Arg Gln Ala Gln Leu Ala Ser Tyr Asn Asp Tyr Arg Glu Met Cys 
            420                 425                 430         


Gly Tyr Pro Arg Val Thr Asp Phe Asn Gln Ile Thr Gly Asp Glu Tyr 
        435                 440                 445             


Ala Gln Gln Lys Leu Lys Glu Leu Tyr Gly His Val Asp Lys Ile Glu 
    450                 455                 460                 


Leu Phe Val Gly Leu Tyr Ala Glu Asp Val Arg Lys Asn Ser Ala Ile 
465                 470                 475                 480 


Pro Pro Leu Val Ala Arg Ile Ile Gly Ile Asp Ala Phe Ser Gln Ala 
                485                 490                 495     


Leu Thr Asn Pro Leu Leu Ser Pro Lys Val Phe Asn Lys Glu Thr Phe 
            500                 505                 510         


Ser Glu Val Gly Trp Glu Ile Ile Gln Asn Thr Lys Thr Val Ser Asp 
        515                 520                 525             


Leu Val Asn Arg Asn Val Pro Pro Ser Asp Pro Lys Tyr Lys Val Ser 
    530                 535                 540                 


Phe Glu Xaa 
545         


<210>  14
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus heme peroxide sequence


<220>
<221>  misc_feature
<222>  (540)..(540)
<223>  Xaa can be any naturally occurring amino acid

<400>  14

Arg Asp Thr Ser Lys Asp Gly Phe Arg Asn Lys Leu Glu Thr Tyr Ala 
1               5                   10                  15      


Leu Thr His Phe Lys Pro Ile Trp Asn Leu Ile Gln Ser Asn Asp Thr 
            20                  25                  30          


Leu Lys Lys Lys Val Asn Lys Phe Leu Val Asn Asn Ala Ile Tyr Lys 
        35                  40                  45              


Val Pro Thr Arg Pro Tyr Pro Phe Ser Thr Met Ser Pro Tyr Thr Ser 
    50                  55                  60                  


Trp Asp Ser Leu Ser Asp Arg Thr Tyr Ser Gly Leu His Leu Pro Pro 
65                  70                  75                  80  


Leu Asp Trp Gln Pro Leu Thr Asn Glu Asn His Leu Lys Leu Lys Leu 
                85                  90                  95      


Ala Asp Thr Lys Asp Phe Glu Lys Lys Leu Pro Ala Ile Glu Asp Leu 
            100                 105                 110         


Arg Gly Leu Tyr Arg Lys Ser Gly Glu Thr Lys Tyr Ser Pro Lys Ser 
        115                 120                 125             


Thr Leu Ile Phe Pro Tyr Phe Val Gln Trp Phe Thr Asp Ser Phe Leu 
    130                 135                 140                 


Arg Thr Asp Arg His Asn His Arg Lys Asn Thr Ser Asn His Gln Ile 
145                 150                 155                 160 


Asp Leu Cys Thr Val Tyr Gly Leu Asn Ala Lys Ile Thr His Leu Leu 
                165                 170                 175     


Arg Ser Tyr Gln Gly Gly Lys Leu Lys Ser Gln Ile Ile Asn Gly Glu 
            180                 185                 190         


Glu Tyr Pro Pro Phe Tyr Tyr Asp Glu Lys Gly Glu Ala Lys Lys Glu 
        195                 200                 205             


Phe Ile Gly Leu Pro His Gln Leu Asp Asn Asp Gly Asn Pro Lys Ala 
    210                 215                 220                 


Asp Thr Phe Pro Leu Asp Lys Lys Gln Lys Leu Phe Ala Met Gly Val 
225                 230                 235                 240 


Glu Val Glu Arg Ser Asn Val Gln Ile Gly Tyr Val Met Leu Asn Val 
                245                 250                 255     


Leu Ala Leu Arg Glu His Asn Arg Leu Cys Glu Leu Leu Ala Lys Thr 
            260                 265                 270         


Tyr Pro Ser Trp Asp Asp Glu Arg Leu Phe Gln Thr Ala Arg Asn Ile 
        275                 280                 285             


Leu Ile Val Glu Val Leu Arg Ile Val Val Glu Asp Tyr Val Asn His 
    290                 295                 300                 


Ile Thr Pro Tyr His Phe Gln Phe Ile Thr Asp Pro Leu Thr Phe Ser 
305                 310                 315                 320 


Asn Glu Lys Trp Tyr Arg Gln Asn Trp Met Thr Val Glu Phe Thr Leu 
                325                 330                 335     


Val Tyr Arg Trp His Ser Met Leu Pro Asp Thr Leu Ile Tyr Asn Gly 
            340                 345                 350         


Gln Lys Ile Pro Thr Tyr Glu Thr Gln Trp Asn Asn Glu Met Ile Ile 
        355                 360                 365             


Lys Gln Gly Leu Gly Ala Leu Phe Glu Glu Ser Cys Ser Gln Pro Cys 
    370                 375                 380                 


Ala Gln Leu Ser Leu Phe Asn Thr Pro Glu Phe Leu Ile Pro Val Glu 
385                 390                 395                 400 


Leu Ala Ser Val Arg Phe Gly Arg Glu Val Lys Leu Arg Ser Tyr Asn 
                405                 410                 415     


Asp Tyr Arg Gln Leu Cys Lys Tyr Pro Arg Val Thr Asp Phe Asp Gln 
            420                 425                 430         


Ile Ser Ser Asp Lys Asn Ile Gln Lys Glu Leu Gln Arg Leu Tyr Gly 
        435                 440                 445             


His Val Asp Asn Ile Glu Leu Tyr Val Gly Ile Tyr Ala Glu Asp Leu 
    450                 455                 460                 


Arg Glu Asn Ser Ala Leu Pro Ser Leu Val Gly Arg Leu Ile Gly Ile 
465                 470                 475                 480 


Asp Ala Phe Ser Gln Val Leu Thr Asn Pro Leu Leu Ala Glu Ser Val 
                485                 490                 495     


Phe His Pro Glu Thr Phe Ser Pro Val Gly Trp Glu Glu Ile Gln Asn 
            500                 505                 510         


Thr Lys Thr Leu Ser Gln Leu Leu His Arg Asn Leu Pro Pro Ser Asp 
        515                 520                 525             


Lys Lys Tyr Arg Val Ser Phe Asp Arg Ala Ser Xaa 
    530                 535                 540 


<210>  15
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus heme peroxide sequence


<220>
<221>  misc_feature
<222>  (544)..(544)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Ala Gly Lys Arg Asp Thr Ser Lys Asp Gly Phe Asp Asn Lys Val Gln 
1               5                   10                  15      


Thr Phe Leu Leu Thr Asn Phe Lys Gly Ile Trp Glu Ile Val Gln Ser 
            20                  25                  30          


Asn Glu Phe Leu Lys Arg Lys Val Asn Lys Thr Leu Ile Asn Ser Leu 
        35                  40                  45              


Ile Tyr Lys Ile Pro Thr Arg Pro Asn Pro Tyr Ser Met Met Thr Leu 
    50                  55                  60                  


Asp Glu Tyr Ile Pro Asp Thr Lys Ile Pro Lys Lys Thr Asp Thr Tyr 
65                  70                  75                  80  


Thr Ser Trp Glu Leu Leu Asn Asp Arg Thr Tyr Ile Gly Arg His Leu 
                85                  90                  95      


Pro Pro Asp Pro Lys Phe Asn Ser Glu Gly Asn Leu Pro Lys Val Glu 
            100                 105                 110         


Asp Leu Ala Val Leu Phe Arg Lys Arg Asp Gly Lys Thr Ile Tyr Ser 
        115                 120                 125             


Pro Lys Ser Thr Met Leu Phe Pro Tyr Trp Val Gln Trp Phe Thr Asp 
    130                 135                 140                 


Ser Phe Leu Arg Ile Asp His Thr Lys Glu Lys Lys Leu Lys Asn Thr 
145                 150                 155                 160 


Ser Asn His Glu Ile Asp Leu Cys Asn Val Tyr Gly Leu Asn Arg Lys 
                165                 170                 175     


Arg Thr His Leu Leu Arg Thr Phe Lys Gly Gly Lys Phe Lys Thr Gln 
            180                 185                 190         


Lys Leu Lys Arg Gln Asp Gly Ile Glu Glu Glu Tyr Pro Leu Phe Tyr 
        195                 200                 205             


Tyr Ala Asp Pro Ala Gln Gly Ile Val Asp Pro Gln Phe Asp Gly Leu 
    210                 215                 220                 


Tyr Glu Pro Ile Asn Asp Glu Lys Arg Leu Pro Ala Asp Lys Lys Gln 
225                 230                 235                 240 


Tyr Leu Phe Ala Met Gly Val Glu Arg Ala Asn Val Gln Ile Gly Tyr 
                245                 250                 255     


Val Met Leu Asn Thr Leu Cys Ile Arg Glu His Asn Arg Leu Cys Asp 
            260                 265                 270         


Glu Leu Ala Ser Asn Tyr Pro Asp Trp Asp Asp Glu Arg Leu Phe Gln 
        275                 280                 285             


Thr Ser Arg Asn Ile Leu Met Ala Ile Ile Leu Asn Ile Ile Met Glu 
    290                 295                 300                 


Glu Tyr Ile Asn His Ile Thr Pro Tyr His Phe Lys Leu Phe Ala Asp 
305                 310                 315                 320 


Pro Ala Ala Phe Val Lys Glu Ser Trp Tyr Arg Pro Asn Trp Met Thr 
                325                 330                 335     


Ile Glu Phe Asp Phe Val Tyr Arg Trp His Ser Ala Ile Pro Glu Thr 
            340                 345                 350         


Phe Ile Tyr Asp Gly Gln Pro Thr Asp Ile Ala Ala Ser Leu Trp Asn 
        355                 360                 365             


Asn Lys Met Phe Ile Asp Lys Gly Leu Gly Ala Leu Met Glu Glu Thr 
    370                 375                 380                 


Cys Ser Gln Pro Gly Thr Arg Ile Gly Leu Phe Asn Thr Pro Asp Ile 
385                 390                 395                 400 


Leu Val Glu Leu Thr Glu Leu Pro Ser Ile Arg Leu Gly Arg Gln Leu 
                405                 410                 415     


Gln Leu Ala Ser Tyr Asn Asp Tyr Arg Glu Met Cys Gly Phe Pro Arg 
            420                 425                 430         


Val Thr Lys Phe Glu Gln Ile Thr Gly Asp Glu Phe Ala Gln Glu Lys 
        435                 440                 445             


Leu Lys Glu Leu Tyr Gly His Val Asp Asn Ile Glu Phe Tyr Val Gly 
    450                 455                 460                 


Leu Tyr Ala Glu Glu Val Arg Lys Asn Ser Thr Ile Pro Pro Leu Val 
465                 470                 475                 480 


Ala Arg Leu Ile Gly Ile Asp Ala Phe Ser Glu Ala Leu Asn Asn Pro 
                485                 490                 495     


Leu Leu Ser Pro Thr Ile Phe Asn Lys Asp Thr Phe Ser Pro Val Gly 
            500                 505                 510         


Trp Glu Ile Ile Gln Asn Thr Lys Thr Val Ser Asp Leu Ile Asn Arg 
        515                 520                 525             


Asn Val Pro Pro Ser Asp Lys Lys Tyr Lys Val Thr Phe Asp Leu Xaa 
    530                 535                 540                 


