                         SEQUENCE LISTING

<110>  ALEXERA AB
 
<120>  METHODS FOR IDENTIFYING THERAPEUTIC AGENTS

<130>  MST3

<150>  SE 1730249-8
<151>  2017-09-13

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  4579
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (274)..(1605)

<400>  1
agacacgaca ttgcagcact ggtgaccgga tccagagcgg agccaggctg cagtggtggg       60

gaggaccggg caggtccaga tgactttgaa gggactccag aggaaggaga gagtggagga      120

ggagggcttt gggttaggga gagtgctttc gtttgtttta aatgggagaa actggagcat      180

gttgccaagg gcagagagcc agcagagagg ggtgaatgga agaaggagcg agaagggggt      240

tactgacgaa gccttatcct ggaggagaga agg atg gac tcc aga gcc cag ctt       294
                                     Met Asp Ser Arg Ala Gln Leu          
                                     1               5                    

tgg gga ctg gcc ttg aat aaa agg agg gcc act cta cct cat cct gga        342
Trp Gly Leu Ala Leu Asn Lys Arg Arg Ala Thr Leu Pro His Pro Gly           
        10                  15                  20                        

ggg agc acg aac cta aag gca gac cca gaa gag ctt ttt aca aaa cta        390
Gly Ser Thr Asn Leu Lys Ala Asp Pro Glu Glu Leu Phe Thr Lys Leu           
    25                  30                  35                            

gag aaa att ggg aag ggc tcc ttt gga gag gtg ttc aaa ggc att gac        438
Glu Lys Ile Gly Lys Gly Ser Phe Gly Glu Val Phe Lys Gly Ile Asp           
40                  45                  50                  55            

aat cgg act cag aaa gtg gtt gcc ata aag atc att gat ctg gaa gaa        486
Asn Arg Thr Gln Lys Val Val Ala Ile Lys Ile Ile Asp Leu Glu Glu           
                60                  65                  70                

gct gaa gat gag ata gag gac att caa caa gaa atc aca gtg ctg agt        534
Ala Glu Asp Glu Ile Glu Asp Ile Gln Gln Glu Ile Thr Val Leu Ser           
            75                  80                  85                    

cag tgt gac agt cca tat gta acc aaa tat tat gga tcc tat ctg aag        582
Gln Cys Asp Ser Pro Tyr Val Thr Lys Tyr Tyr Gly Ser Tyr Leu Lys           
        90                  95                  100                       

gat aca aaa tta tgg ata ata atg gaa tat ctt ggt gga ggc tcc gca        630
Asp Thr Lys Leu Trp Ile Ile Met Glu Tyr Leu Gly Gly Gly Ser Ala           
    105                 110                 115                           

cta gat cta tta gaa cct ggc cca tta gat gaa acc cag atc gct act        678
Leu Asp Leu Leu Glu Pro Gly Pro Leu Asp Glu Thr Gln Ile Ala Thr           
120                 125                 130                 135           

ata tta aga gaa ata ctg aaa gga ctc gat tat ctc cat tcg gag aag        726
Ile Leu Arg Glu Ile Leu Lys Gly Leu Asp Tyr Leu His Ser Glu Lys           
                140                 145                 150               

aaa atc cac aga gac att aaa gcg gcc aac gtc ctg ctg tct gag cat        774
Lys Ile His Arg Asp Ile Lys Ala Ala Asn Val Leu Leu Ser Glu His           
            155                 160                 165                   

ggc gag gtg aag ctg gcg gac ttt ggc gtg gct ggc cag ctg aca gac        822
Gly Glu Val Lys Leu Ala Asp Phe Gly Val Ala Gly Gln Leu Thr Asp           
        170                 175                 180                       

acc cag atc aaa agg aac acc ttc gtg ggc acc cca ttc tgg atg gca        870
Thr Gln Ile Lys Arg Asn Thr Phe Val Gly Thr Pro Phe Trp Met Ala           
    185                 190                 195                           

ccc gag gtc atc aaa cag tcg gcc tat gac tcg aag gca gac atc tgg        918
Pro Glu Val Ile Lys Gln Ser Ala Tyr Asp Ser Lys Ala Asp Ile Trp           
200                 205                 210                 215           

tcc ctg ggc ata aca gct att gaa ctt gca aga ggg gaa cca cct cat        966
Ser Leu Gly Ile Thr Ala Ile Glu Leu Ala Arg Gly Glu Pro Pro His           
                220                 225                 230               

tcc gag ctg cac ccc atg aaa gtt tta ttc ctc att cca aag aac aac       1014
Ser Glu Leu His Pro Met Lys Val Leu Phe Leu Ile Pro Lys Asn Asn           
            235                 240                 245                   

cca ccg acg ttg gaa gga aac tac agt aaa ccc ctc aag gag ttt gtg       1062
Pro Pro Thr Leu Glu Gly Asn Tyr Ser Lys Pro Leu Lys Glu Phe Val           
        250                 255                 260                       

gag gcc tgt ttg aat aag gag ccg agc ttt aga ccc act gct aag gag       1110
Glu Ala Cys Leu Asn Lys Glu Pro Ser Phe Arg Pro Thr Ala Lys Glu           
    265                 270                 275                           

tta ttg aag cac aag ttt ata cta cgc aat gca aag aaa act tcc tac       1158
Leu Leu Lys His Lys Phe Ile Leu Arg Asn Ala Lys Lys Thr Ser Tyr           
280                 285                 290                 295           

ttg acc gag ctc atc gac agg tac aag aga tgg aag gcc gag cag agc       1206
Leu Thr Glu Leu Ile Asp Arg Tyr Lys Arg Trp Lys Ala Glu Gln Ser           
                300                 305                 310               

cat gac gac tcg agc tcc gag gat tcc gac gcg gaa aca gat ggc caa       1254
His Asp Asp Ser Ser Ser Glu Asp Ser Asp Ala Glu Thr Asp Gly Gln           
            315                 320                 325                   

gcc tcg ggg ggc agt gat tct ggg gac tgg atc ttc aca atc cga gaa       1302
Ala Ser Gly Gly Ser Asp Ser Gly Asp Trp Ile Phe Thr Ile Arg Glu           
        330                 335                 340                       

aaa gat ccc aag aat ctc gag aat gga gct ctt cag cca tcg gac ttg       1350
Lys Asp Pro Lys Asn Leu Glu Asn Gly Ala Leu Gln Pro Ser Asp Leu           
    345                 350                 355                           

gac aga aat aag atg aaa gac atc cca aag agg cct ttc tct cag tgt       1398
Asp Arg Asn Lys Met Lys Asp Ile Pro Lys Arg Pro Phe Ser Gln Cys           
360                 365                 370                 375           

tta tct aca att att tct cct ctg ttt gca gag ttg aag gag aag agc       1446
Leu Ser Thr Ile Ile Ser Pro Leu Phe Ala Glu Leu Lys Glu Lys Ser           
                380                 385                 390               

cag gcg tgc gga ggg aac ttg ggg tcc att gaa gag ctg cga ggg gcc       1494
Gln Ala Cys Gly Gly Asn Leu Gly Ser Ile Glu Glu Leu Arg Gly Ala           
            395                 400                 405                   

atc tac cta gcg gag gag gcg tgc cct ggc atc tcc gac acc atg gtg       1542
Ile Tyr Leu Ala Glu Glu Ala Cys Pro Gly Ile Ser Asp Thr Met Val           
        410                 415                 420                       

gcc cag ctc gtg cag cgg ctc cag aga tac tct cta agt ggt gga gga       1590
Ala Gln Leu Val Gln Arg Leu Gln Arg Tyr Ser Leu Ser Gly Gly Gly           
    425                 430                 435                           

act tca tcc cac tga aattcctttg gcatttgggg ttttgttttt ccttttttcc       1645
Thr Ser Ser His                                                           
440                                                                       

ttcttcatcc tcctcctttt ttaaaagtca acgagagcct tcgctgactc caccgaagag     1705

gtgcgccact gggagccacc ccagcgccag gcgcccgtcc agggacacac acagtcttca     1765

ctgtgctgca gccagatgaa gtctctcaga tgggtgggga gggtcagctc cttccagcga     1825

tcattttatt ttattttatt acttttgttt ttaattttaa ccatagtgca catattccag     1885

gaaagtgtct ttaaaaacaa aaacaaaccc tgaaatgtat atttgggatt atgataaggc     1945

aactaaagac atgaaacctc aggtatcctg ctttaagttg ataactccct ctgggagctg     2005

gagaatcgct ctggtggatg ggtgtacaga tttgtatata atgtcatttt tacggaaacc     2065

ctttcggcgt gcataaggaa tcactgtgta caaactggcc aagtgcttct gtagataacg     2125

tcagtggagt aaatattcga caggccataa cttgagtcta ttgccttgcc tttattacat     2185

gtacattttg aattctgtga ccagtgattt gggttttatt ttgtatttgc agggtttgtc     2245

attaataatt aatgcccctc tcttacagaa cactcctatt tgtacctcaa caaatgcaaa     2305

ttttccccgt ttgccctacg ccccttttgg tacacctaga ggttgatttc ctttttcatc     2365

gatggtacta tttcttagtg ttttaaattg gaacatatct tgcctcatga agctttaaat     2425

tataattttc agtttctccc catgaagcgc tctcgtctga catttgtttg gaatcgtgcc     2485

actgctggtc tgcgccagat gtaccgtcct ttccaatacg attttctgtt gcaccttgta     2545

gtggattctg catatcatct ttcccaccta aaaatgtctg aatgcttaca caaataaatt     2605

ttataacacg cttattttgc atactccttg aaatgtgact cttcagagga cagggcacct     2665

gctgtgtatg tgtggccgtg cgtgtgtact cgtggctgtg tgtgtgtgat gagacacttt     2725

ggaagactcc agggagaagt ccccaggcct ggagctgccg agtgcccagg tcagcgccct     2785

ggactgcttg cgcacttgct caccgagatg atgcagttgg aggttgctga tctgtgcgat     2845

tgctgtagcg gttgccgggg accttaagag ttattttgct tctctggaag gggcctatgc     2905

ttgctaggca ggcagccagt gtgtctgttt ttcttggttt gctgtgggac cttgcttggc     2965

gagggggaaa atctctgggt ttctggagtg ggagggttcg tgcagcagct gttgactggt     3025

acatgaagca ttcttttatg tttgttgaag ctgatgattg acatctcccg tgggtgtgcc     3085

agttcttgtg gagttaagac aggatttttg gaagcaagga agttagtggg tgagcttggg     3145

gatgtagctc agctatctgc tggtctagtg gcctctaagc tatagggagg ggacagagcc     3205

ctgagctaca gatgcttgag tgggttattg tgtcggtttg ctagtgcagt ctggttttta     3265

agctctaaaa ttgaggtatt ttattagaag tggatttggg ttgaactctt aatttgtata     3325

agggatatat tttggttggg gaaatagaac tgagttgcta attcttattg tactcattac     3385

tccatacaag aatgttatgt tgaataataa aattggagaa gatttcattt tgtgtttcca     3445

gggagtattc tgtgtgggga actgtttcct tacgtgaggc cggcggcata agtcaaagat     3505

gagttttgtc cttgcgaatc acacagattg agtctgtgtt ccccagggtg tgccgttacc     3565

tgatttttaa gtgagccagg gcggacagca gcttttctga tttacagagt tcttcagatt     3625

tacaaatgga caatgacatc acagttttta gcactgaagc cagtctcatg ctagtaacag     3685

tgggtgagcc gctcgaggga ctgggttcta atgaatactg gtatgaacgg ggagtctctg     3745

cagtcgccag acaaatcata ctcagcccct tcccccgtag agcaacaagt ggttctttta     3805

gagttgactg gcagcatttc ctgtcggggg aggtggggtt tgatggagtt agaaagctcg     3865

cctctgtgta cattctctcc tgggctgtta ctttctgtag acgcacaaaa tcagccccaa     3925

tgtttttaag ggcatcttag ccaaggaagc tggcttttgt gtcgccactt ccaggcctgc     3985

attaagagag agcccaggca ccagggctac cactggaacc tgcctcagcg tcaactgctg     4045

ctggtctgta gccaggccca gcctttgaga cgggtttact gtcaccagta gcctctcagt     4105

gccagccctg agctgctcct ggctcagctg cccagagcct gcagcctggg gaggtactca     4165

gcctctggga gacgagggcc gtggactggg tggctggtag ctcctgcgtt tttgagctgt     4225

gtcctggctg gctgctgcca atgaggtgga caccagtgtg gtttggggtg cactggccac     4285

ttcttgctgg gttctgattt tcttggaagt gcatctgcct tccttatcca atagttttat     4345

ccctgcattg ctcttgtgaa gtggctggtt tggttctgta tgtagcattt tgtacctttc     4405

ctctggcaaa acactgtcag tttataaaca ttttttatat ttccctcctt taaaaacagc     4465

ttgtgtattt ctgctataaa atgtgtcagc aaaggcagag tgacctaata gggcatgttc     4525

ttaagcacag ggactgtatc atgcaggggc caataaagct caagaaaacg agta           4579


<210>  2
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Ser Arg Ala Gln Leu Trp Gly Leu Ala Leu Asn Lys Arg Arg 
1               5                   10                  15      


Ala Thr Leu Pro His Pro Gly Gly Ser Thr Asn Leu Lys Ala Asp Pro 
            20                  25                  30          


Glu Glu Leu Phe Thr Lys Leu Glu Lys Ile Gly Lys Gly Ser Phe Gly 
        35                  40                  45              


Glu Val Phe Lys Gly Ile Asp Asn Arg Thr Gln Lys Val Val Ala Ile 
    50                  55                  60                  


Lys Ile Ile Asp Leu Glu Glu Ala Glu Asp Glu Ile Glu Asp Ile Gln 
65                  70                  75                  80  


Gln Glu Ile Thr Val Leu Ser Gln Cys Asp Ser Pro Tyr Val Thr Lys 
                85                  90                  95      


Tyr Tyr Gly Ser Tyr Leu Lys Asp Thr Lys Leu Trp Ile Ile Met Glu 
            100                 105                 110         


Tyr Leu Gly Gly Gly Ser Ala Leu Asp Leu Leu Glu Pro Gly Pro Leu 
        115                 120                 125             


Asp Glu Thr Gln Ile Ala Thr Ile Leu Arg Glu Ile Leu Lys Gly Leu 
    130                 135                 140                 


Asp Tyr Leu His Ser Glu Lys Lys Ile His Arg Asp Ile Lys Ala Ala 
145                 150                 155                 160 


Asn Val Leu Leu Ser Glu His Gly Glu Val Lys Leu Ala Asp Phe Gly 
                165                 170                 175     


Val Ala Gly Gln Leu Thr Asp Thr Gln Ile Lys Arg Asn Thr Phe Val 
            180                 185                 190         


Gly Thr Pro Phe Trp Met Ala Pro Glu Val Ile Lys Gln Ser Ala Tyr 
        195                 200                 205             


Asp Ser Lys Ala Asp Ile Trp Ser Leu Gly Ile Thr Ala Ile Glu Leu 
    210                 215                 220                 


Ala Arg Gly Glu Pro Pro His Ser Glu Leu His Pro Met Lys Val Leu 
225                 230                 235                 240 


Phe Leu Ile Pro Lys Asn Asn Pro Pro Thr Leu Glu Gly Asn Tyr Ser 
                245                 250                 255     


Lys Pro Leu Lys Glu Phe Val Glu Ala Cys Leu Asn Lys Glu Pro Ser 
            260                 265                 270         


Phe Arg Pro Thr Ala Lys Glu Leu Leu Lys His Lys Phe Ile Leu Arg 
        275                 280                 285             


Asn Ala Lys Lys Thr Ser Tyr Leu Thr Glu Leu Ile Asp Arg Tyr Lys 
    290                 295                 300                 


Arg Trp Lys Ala Glu Gln Ser His Asp Asp Ser Ser Ser Glu Asp Ser 
305                 310                 315                 320 


Asp Ala Glu Thr Asp Gly Gln Ala Ser Gly Gly Ser Asp Ser Gly Asp 
                325                 330                 335     


Trp Ile Phe Thr Ile Arg Glu Lys Asp Pro Lys Asn Leu Glu Asn Gly 
            340                 345                 350         


Ala Leu Gln Pro Ser Asp Leu Asp Arg Asn Lys Met Lys Asp Ile Pro 
        355                 360                 365             


Lys Arg Pro Phe Ser Gln Cys Leu Ser Thr Ile Ile Ser Pro Leu Phe 
    370                 375                 380                 


Ala Glu Leu Lys Glu Lys Ser Gln Ala Cys Gly Gly Asn Leu Gly Ser 
385                 390                 395                 400 


Ile Glu Glu Leu Arg Gly Ala Ile Tyr Leu Ala Glu Glu Ala Cys Pro 
                405                 410                 415     


Gly Ile Ser Asp Thr Met Val Ala Gln Leu Val Gln Arg Leu Gln Arg 
            420                 425                 430         


Tyr Ser Leu Ser Gly Gly Gly Thr Ser Ser His 
        435                 440             


