                         SEQUENCE LISTING

<110>  B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY
 
<120>  SUCCINATE-REGULATING POLYPEPTIDES AND USE THEREOF

<130>  BGU-P-078-PCT

<150>  US 62/559,694
<151>  2017-09-18

<150>  US 62/623,825
<151>  2018-01-30

<150>  US 62/623,864
<151>  2018-01-30

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  735
<212>  PRT
<213>  Mus musculus

<400>  1

Met Glu Leu Gln Arg Arg Asp Tyr His Val Glu Arg Pro Leu Leu Asn 
1               5                   10                  15      


Gln Glu Gln Leu Glu Asp Leu Gly His Trp Gly Pro Ala Ala Lys Thr 
            20                  25                  30          


His Gln Trp Arg Thr Trp Phe Arg Cys Ser Arg Ala Arg Ala His Ser 
        35                  40                  45              


Leu Leu Leu Gln His Val Pro Val Leu Gly Trp Leu Pro Arg Tyr Pro 
    50                  55                  60                  


Val Arg Glu Trp Leu Leu Gly Asp Leu Leu Ser Gly Leu Ser Val Ala 
65                  70                  75                  80  


Ile Met Gln Leu Pro Gln Gly Leu Ala Tyr Ala Leu Leu Ala Gly Leu 
                85                  90                  95      


Pro Pro Met Phe Gly Leu Tyr Ser Ser Phe Tyr Pro Val Phe Ile Tyr 
            100                 105                 110         


Phe Leu Phe Gly Thr Ser Arg His Ile Ser Val Gly Thr Phe Ala Val 
        115                 120                 125             


Met Ser Val Met Val Gly Ser Val Thr Glu Ser Leu Thr Ala Asp Lys 
    130                 135                 140                 


Ala Phe Val Gln Gly Leu Asn Ala Thr Ala Asp Asp Ala Arg Val Gln 
145                 150                 155                 160 


Val Ala Tyr Thr Leu Ser Phe Leu Val Gly Leu Phe Gln Val Gly Leu 
                165                 170                 175     


Gly Leu Val His Phe Gly Phe Val Val Thr Tyr Leu Ser Glu Pro Leu 
            180                 185                 190         


Val Arg Ser Tyr Thr Thr Ala Ala Ser Val Gln Val Leu Val Ser Gln 
        195                 200                 205             


Leu Lys Tyr Val Phe Gly Ile Lys Leu Ser Ser His Ser Gly Pro Leu 
    210                 215                 220                 


Ser Val Ile Tyr Thr Val Leu Glu Val Cys Ala Gln Leu Pro Glu Thr 
225                 230                 235                 240 


Val Pro Gly Thr Val Val Thr Ala Ile Val Ala Gly Val Ala Leu Val 
                245                 250                 255     


Leu Val Lys Leu Leu Asn Glu Lys Leu His Arg Arg Leu Pro Leu Pro 
            260                 265                 270         


Ile Pro Gly Glu Leu Leu Thr Leu Ile Gly Ala Thr Gly Ile Ser Tyr 
        275                 280                 285             


Gly Val Lys Leu Asn Asp Arg Phe Lys Val Asp Val Val Gly Asn Ile 
    290                 295                 300                 


Thr Thr Gly Leu Ile Pro Pro Val Ala Pro Lys Thr Glu Leu Phe Ala 
305                 310                 315                 320 


Thr Leu Val Gly Asn Ala Phe Ala Ile Ala Val Val Gly Phe Ala Ile 
                325                 330                 335     


Ala Ile Ser Leu Gly Lys Ile Phe Ala Leu Arg His Gly Tyr Arg Val 
            340                 345                 350         


Asp Ser Asn Gln Glu Leu Val Ala Leu Gly Leu Ser Asn Leu Ile Gly 
        355                 360                 365             


Gly Phe Phe Gln Cys Phe Pro Val Ser Cys Ser Met Ser Arg Ser Leu 
    370                 375                 380                 


Val Gln Glu Ser Thr Gly Gly Asn Thr Gln Val Ala Gly Ala Val Ser 
385                 390                 395                 400 


Ser Leu Phe Ile Leu Leu Ile Ile Val Lys Leu Gly Glu Leu Phe Arg 
                405                 410                 415     


Asp Leu Pro Lys Ala Val Leu Ala Ala Val Ile Ile Val Asn Leu Lys 
            420                 425                 430         


Gly Met Met Lys Gln Phe Ser Asp Ile Cys Ser Leu Trp Lys Ala Asn 
        435                 440                 445             


Arg Val Asp Leu Leu Ile Trp Leu Val Thr Phe Val Ala Thr Ile Leu 
    450                 455                 460                 


Leu Asn Leu Asp Ile Gly Leu Ala Val Ser Ile Val Phe Ser Leu Leu 
465                 470                 475                 480 


Leu Val Val Val Arg Met Gln Leu Pro His Tyr Ser Val Leu Gly Gln 
                485                 490                 495     


Val Pro Asp Thr Asp Ile Tyr Arg Asp Val Ala Glu Tyr Ser Gly Ala 
            500                 505                 510         


Lys Glu Val Pro Gly Val Lys Val Phe Arg Ser Ser Ala Thr Leu Tyr 
        515                 520                 525             


Phe Ala Asn Ala Glu Leu Tyr Ser Asp Ser Leu Lys Glu Lys Cys Gly 
    530                 535                 540                 


Val Asp Val Asp Arg Leu Ile Thr Gln Lys Lys Lys Arg Ile Lys Lys 
545                 550                 555                 560 


Gln Glu Met Lys Leu Lys Arg Met Lys Lys Ala Lys Lys Ser Gln Lys 
                565                 570                 575     


Gln Asp Ala Ser Ser Lys Ile Ser Ser Val Ser Val Asn Val Asn Thr 
            580                 585                 590         


Asn Leu Glu Asp Val Lys Ser Asn Asp Val Glu Gly Ser Glu Ala Lys 
        595                 600                 605             


Val His Gln Gly Glu Glu Leu Gln Asp Val Val Ser Ser Asn Gln Glu 
    610                 615                 620                 


Asp Ala Lys Ala Pro Thr Met Thr Ser Leu Lys Ser Leu Gly Leu Pro 
625                 630                 635                 640 


Gln Pro Gly Phe His Ser Leu Ile Leu Asp Leu Ser Thr Leu Ser Phe 
                645                 650                 655     


Val Asp Thr Val Cys Ile Lys Ser Leu Lys Asn Ile Phe Arg Asp Phe 
            660                 665                 670         


Arg Glu Ile Glu Val Glu Val Tyr Ile Ala Ala Cys Tyr Ser Pro Val 
        675                 680                 685             


Val Ala Gln Leu Glu Ala Gly His Phe Phe Asp Glu Ser Ile Thr Lys 
    690                 695                 700                 


Gln His Val Phe Ala Ser Val His Asp Ala Val Thr Phe Ala Leu Ser 
705                 710                 715                 720 


His Arg Lys Ser Val Pro Lys Ser Pro Val Leu Ala Thr Lys Leu 
                725                 730                 735 


<210>  2
<211>  759
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Leu Ala Asp Ala Ser Gly Pro Arg Asp Thr Gln Ala Leu Leu 
1               5                   10                  15      


Ser Ala Thr Gln Ala Met Asp Leu Arg Arg Arg Asp Tyr His Met Glu 
            20                  25                  30          


Arg Pro Leu Leu Asn Gln Glu His Leu Glu Glu Leu Gly Arg Trp Gly 
        35                  40                  45              


Ser Ala Pro Arg Thr His Gln Trp Arg Thr Trp Leu Gln Cys Ser Arg 
    50                  55                  60                  


Ala Arg Ala Tyr Ala Leu Leu Leu Gln His Leu Pro Val Leu Val Trp 
65                  70                  75                  80  


Leu Pro Arg Tyr Pro Val Arg Asp Trp Leu Leu Gly Asp Leu Leu Ser 
                85                  90                  95      


Gly Leu Ser Val Ala Ile Met Gln Leu Pro Gln Gly Leu Ala Tyr Ala 
            100                 105                 110         


Leu Leu Ala Gly Leu Pro Pro Val Phe Gly Leu Tyr Ser Ser Phe Tyr 
        115                 120                 125             


Pro Val Phe Ile Tyr Phe Leu Phe Gly Thr Ser Arg His Ile Ser Val 
    130                 135                 140                 


Gly Thr Phe Ala Val Met Ser Val Met Val Gly Ser Val Thr Glu Ser 
145                 150                 155                 160 


Leu Ala Pro Gln Ala Leu Asn Asp Ser Met Ile Asn Glu Thr Ala Arg 
                165                 170                 175     


Asp Ala Ala Arg Val Gln Val Ala Ser Thr Leu Ser Val Leu Val Gly 
            180                 185                 190         


Leu Phe Gln Val Gly Leu Gly Leu Ile His Phe Gly Phe Val Val Thr 
        195                 200                 205             


Tyr Leu Ser Glu Pro Leu Val Arg Gly Tyr Thr Thr Ala Ala Ala Val 
    210                 215                 220                 


Gln Val Phe Val Ser Gln Leu Lys Tyr Val Phe Gly Leu His Leu Ser 
225                 230                 235                 240 


Ser His Ser Gly Pro Leu Ser Leu Ile Tyr Thr Val Leu Glu Val Cys 
                245                 250                 255     


Trp Lys Leu Pro Gln Ser Lys Val Gly Thr Val Val Thr Ala Ala Val 
            260                 265                 270         


Ala Gly Val Val Leu Val Val Val Lys Leu Leu Asn Asp Lys Leu Gln 
        275                 280                 285             


Gln Gln Leu Pro Met Pro Ile Pro Gly Glu Leu Leu Thr Leu Ile Gly 
    290                 295                 300                 


Ala Thr Gly Ile Ser Tyr Gly Met Gly Leu Lys His Arg Phe Glu Val 
305                 310                 315                 320 


Asp Val Val Gly Asn Ile Pro Ala Gly Leu Val Pro Pro Val Ala Pro 
                325                 330                 335     


Asn Thr Gln Leu Phe Ser Lys Leu Val Gly Ser Ala Phe Thr Ile Ala 
            340                 345                 350         


Val Val Gly Phe Ala Ile Ala Ile Ser Leu Gly Lys Ile Phe Ala Leu 
        355                 360                 365             


Arg His Gly Tyr Arg Val Asp Ser Asn Gln Glu Leu Val Ala Leu Gly 
    370                 375                 380                 


Leu Ser Asn Leu Ile Gly Gly Ile Phe Gln Cys Phe Pro Val Ser Cys 
385                 390                 395                 400 


Ser Met Ser Arg Ser Leu Val Gln Glu Ser Thr Gly Gly Asn Ser Gln 
                405                 410                 415     


Val Ala Gly Ala Ile Ser Ser Leu Phe Ile Leu Leu Ile Ile Val Lys 
            420                 425                 430         


Leu Gly Glu Leu Phe His Asp Leu Pro Lys Ala Val Leu Ala Ala Ile 
        435                 440                 445             


Ile Ile Val Asn Leu Lys Gly Met Leu Arg Gln Leu Ser Asp Met Arg 
    450                 455                 460                 


Ser Leu Trp Lys Ala Asn Arg Ala Asp Leu Leu Ile Trp Leu Val Thr 
465                 470                 475                 480 


Phe Thr Ala Thr Ile Leu Leu Asn Leu Asp Leu Gly Leu Val Val Ala 
                485                 490                 495     


Val Ile Phe Ser Leu Leu Leu Val Val Val Arg Thr Gln Met Pro His 
            500                 505                 510         


Tyr Ser Val Leu Gly Gln Val Pro Asp Thr Asp Ile Tyr Arg Asp Val 
        515                 520                 525             


Ala Glu Tyr Ser Glu Ala Lys Glu Val Arg Gly Val Lys Val Phe Arg 
    530                 535                 540                 


Ser Ser Ala Thr Val Tyr Phe Ala Asn Ala Glu Phe Tyr Ser Asp Ala 
545                 550                 555                 560 


Leu Lys Gln Arg Cys Gly Val Asp Val Asp Phe Leu Ile Ser Gln Lys 
                565                 570                 575     


Lys Lys Leu Leu Lys Lys Gln Glu Gln Leu Lys Leu Lys Gln Leu Gln 
            580                 585                 590         


Lys Glu Glu Lys Leu Arg Lys Gln Ala Ala Ser Pro Lys Gly Ala Ser 
        595                 600                 605             


Val Ser Ile Asn Val Asn Thr Ser Leu Glu Asp Met Arg Ser Asn Asn 
    610                 615                 620                 


Val Glu Asp Cys Lys Met Met Gln Val Ser Ser Gly Asp Lys Met Glu 
625                 630                 635                 640 


Asp Ala Thr Ala Asn Gly Gln Glu Asp Ser Lys Ala Pro Asp Gly Ser 
                645                 650                 655     


Thr Leu Lys Ala Leu Gly Leu Pro Gln Pro Asp Phe His Ser Leu Ile 
            660                 665                 670         


Leu Asp Leu Gly Ala Leu Ser Phe Val Asp Thr Val Cys Leu Lys Ser 
        675                 680                 685             


Leu Lys Asn Ile Phe His Asp Phe Arg Glu Ile Glu Val Glu Val Tyr 
    690                 695                 700                 


Met Ala Ala Cys His Ser Pro Val Val Ser Gln Leu Glu Ala Gly His 
705                 710                 715                 720 


Phe Phe Asp Ala Ser Ile Thr Lys Lys His Leu Phe Ala Ser Val His 
                725                 730                 735     


Asp Ala Val Thr Phe Ala Leu Gln His Pro Arg Pro Val Pro Asp Ser 
            740                 745                 750         


Pro Val Ser Val Thr Arg Leu 
        755                 


<210>  3
<211>  530
<212>  PRT
<213>  Mus musculus

<400>  3

Met Ser Met Pro Asp Ala Met Pro Leu Pro Gly Val Gly Glu Glu Leu 
1               5                   10                  15      


Lys Gln Ala Lys Glu Ile Glu Asp Ala Glu Lys Tyr Ser Phe Met Ala 
            20                  25                  30          


Thr Val Thr Lys Ala Pro Lys Lys Gln Ile Gln Phe Ala Asp Asp Met 
        35                  40                  45              


Gln Glu Phe Thr Lys Phe Pro Thr Lys Thr Gly Arg Arg Ser Leu Ser 
    50                  55                  60                  


Arg Ser Ile Ser Gln Ser Ser Thr Asp Ser Tyr Ser Ser Ala Ala Ser 
65                  70                  75                  80  


Tyr Thr Asp Ser Ser Asp Asp Glu Val Ser Pro Arg Glu Lys Gln Gln 
                85                  90                  95      


Thr Asn Ser Lys Gly Ser Ser Asn Phe Cys Val Lys Asn Ile Lys Gln 
            100                 105                 110         


Ala Glu Phe Gly Arg Arg Glu Ile Glu Ile Ala Glu Gln Asp Met Ser 
        115                 120                 125             


Ala Leu Ile Ser Leu Arg Lys Arg Ala Gln Gly Glu Lys Pro Leu Ala 
    130                 135                 140                 


Gly Ala Lys Ile Val Gly Cys Thr His Ile Thr Ala Gln Thr Ala Val 
145                 150                 155                 160 


Leu Ile Glu Thr Leu Cys Ala Leu Gly Ala Gln Cys Arg Trp Ser Ala 
                165                 170                 175     


Cys Asn Ile Tyr Ser Thr Gln Asn Glu Val Ala Ala Ala Leu Ala Glu 
            180                 185                 190         


Ala Gly Val Ala Val Phe Ala Trp Lys Gly Glu Ser Glu Asp Asp Phe 
        195                 200                 205             


Trp Trp Cys Ile Asp Arg Cys Val Asn Met Asp Gly Trp Gln Ala Asn 
    210                 215                 220                 


Met Ile Leu Asp Asp Gly Gly Asp Leu Thr His Trp Val Tyr Lys Lys 
225                 230                 235                 240 


Tyr Pro Asn Val Phe Lys Lys Ile Arg Gly Ile Val Glu Glu Ser Val 
                245                 250                 255     


Thr Gly Val His Arg Leu Tyr Gln Leu Ser Lys Ala Gly Lys Leu Cys 
            260                 265                 270         


Val Pro Ala Met Asn Val Asn Asp Ser Val Thr Lys Gln Lys Phe Asp 
        275                 280                 285             


Asn Leu Tyr Cys Cys Arg Glu Ser Ile Leu Asp Gly Leu Lys Arg Thr 
    290                 295                 300                 


Thr Asp Val Met Phe Gly Gly Lys Gln Val Val Val Cys Gly Tyr Gly 
305                 310                 315                 320 


Glu Val Gly Lys Gly Cys Cys Ala Ala Leu Lys Ala Leu Gly Ala Ile 
                325                 330                 335     


Val Tyr Ile Thr Glu Ile Asp Pro Ile Cys Ala Leu Gln Ala Cys Met 
            340                 345                 350         


Asp Gly Phe Arg Val Val Lys Leu Asn Glu Val Ile Arg Gln Val Asp 
        355                 360                 365             


Val Val Ile Thr Cys Thr Gly Asn Lys Asn Val Val Thr Arg Glu His 
    370                 375                 380                 


Leu Asp Arg Met Lys Asn Ser Cys Ile Val Cys Asn Met Gly His Ser 
385                 390                 395                 400 


Asn Thr Glu Ile Asp Val Thr Ser Leu Arg Thr Pro Glu Leu Thr Trp 
                405                 410                 415     


Glu Arg Val Arg Ser Gln Val Asp His Val Ile Trp Pro Asp Gly Lys 
            420                 425                 430         


Arg Val Val Leu Leu Ala Glu Gly Arg Leu Leu Asn Leu Ser Cys Ser 
        435                 440                 445             


Thr Val Pro Thr Phe Val Leu Ser Ile Thr Ala Thr Thr Gln Ala Leu 
    450                 455                 460                 


Ala Leu Ile Glu Leu Tyr Asn Ala Pro Glu Gly Arg Tyr Lys Gln Asp 
465                 470                 475                 480 


Val Tyr Leu Leu Pro Lys Lys Met Asp Glu Tyr Val Ala Ser Leu His 
                485                 490                 495     


Leu Pro Ser Phe Asp Ala His Leu Thr Glu Leu Thr Asp Asp Gln Ala 
            500                 505                 510         


Lys Tyr Leu Gly Leu Asn Lys Asn Gly Pro Phe Lys Pro Asn Tyr Tyr 
        515                 520                 525             


Arg Tyr 
    530 


<210>  4
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Met Pro Asp Ala Met Pro Leu Pro Gly Val Gly Glu Glu Leu 
1               5                   10                  15      


Lys Gln Ala Lys Glu Ile Glu Asp Ala Glu Lys Tyr Ser Phe Met Ala 
            20                  25                  30          


Thr Val Thr Lys Ala Pro Lys Lys Gln Ile Gln Phe Ala Asp Asp Met 
        35                  40                  45              


Gln Glu Phe Thr Lys Phe Pro Thr Lys Thr Gly Arg Arg Ser Leu Ser 
    50                  55                  60                  


Arg Ser Ile Ser Gln Ser Ser Thr Asp Ser Tyr Ser Ser Ala Ala Ser 
65                  70                  75                  80  


Tyr Thr Asp Ser Ser Asp Asp Glu Val Ser Pro Arg Glu Lys Gln Gln 
                85                  90                  95      


Thr Asn Ser Lys Gly Ser Ser Asn Phe Cys Val Lys Asn Ile Lys Gln 
            100                 105                 110         


Ala Glu Phe Gly Arg Arg Glu Ile Glu Ile Ala Glu Gln Asp Met Ser 
        115                 120                 125             


Ala Leu Ile Ser Leu Arg Lys Arg Ala Gln Gly Glu Lys Pro Leu Ala 
    130                 135                 140                 


Gly Ala Lys Ile Val Gly Cys Thr His Ile Thr Ala Gln Thr Ala Val 
145                 150                 155                 160 


Leu Ile Glu Thr Leu Cys Ala Leu Gly Ala Gln Cys Arg Trp Ser Ala 
                165                 170                 175     


Cys Asn Ile Tyr Ser Thr Gln Asn Glu Val Ala Ala Ala Leu Ala Glu 
            180                 185                 190         


Ala Gly Val Ala Val Phe Ala Trp Lys Gly Glu Ser Glu Asp Asp Phe 
        195                 200                 205             


Trp Trp Cys Ile Asp Arg Cys Val Asn Met Asp Gly Trp Gln Ala Asn 
    210                 215                 220                 


Met Ile Leu Asp Asp Gly Gly Asp Leu Thr His Trp Val Tyr Lys Lys 
225                 230                 235                 240 


Tyr Pro Asn Val Phe Lys Lys Ile Arg Gly Ile Val Glu Glu Ser Val 
                245                 250                 255     


Thr Gly Val His Arg Leu Tyr Gln Leu Ser Lys Ala Gly Lys Leu Cys 
            260                 265                 270         


Val Pro Ala Met Asn Val Asn Asp Ser Val Thr Lys Gln Lys Phe Asp 
        275                 280                 285             


Asn Leu Tyr Cys Cys Arg Glu Ser Ile Leu Asp Gly Leu Lys Arg Thr 
    290                 295                 300                 


Thr Asp Val Met Phe Gly Gly Lys Gln Val Val Val Cys Gly Tyr Gly 
305                 310                 315                 320 


Glu Val Gly Lys Gly Cys Cys Ala Ala Leu Lys Ala Leu Gly Ala Ile 
                325                 330                 335     


Val Tyr Ile Thr Glu Ile Asp Pro Ile Cys Ala Leu Gln Ala Cys Met 
            340                 345                 350         


Asp Gly Phe Arg Val Val Lys Leu Asn Glu Val Ile Arg Gln Val Asp 
        355                 360                 365             


Val Val Ile Thr Cys Thr Gly Asn Lys Asn Val Val Thr Arg Glu His 
    370                 375                 380                 


Leu Asp Arg Met Lys Asn Ser Cys Ile Val Cys Asn Met Gly His Ser 
385                 390                 395                 400 


Asn Thr Glu Ile Asp Val Thr Ser Leu Arg Thr Pro Glu Leu Thr Trp 
                405                 410                 415     


Glu Arg Val Arg Ser Gln Val Asp His Val Ile Trp Pro Asp Gly Lys 
            420                 425                 430         


Arg Val Val Leu Leu Ala Glu Gly Arg Leu Leu Asn Leu Ser Cys Ser 
        435                 440                 445             


Thr Val Pro Thr Phe Val Leu Ser Ile Thr Ala Thr Thr Gln Ala Leu 
    450                 455                 460                 


Ala Leu Ile Glu Leu Tyr Asn Ala Pro Glu Gly Arg Tyr Lys Gln Asp 
465                 470                 475                 480 


Val Tyr Leu Leu Pro Lys Lys Met Asp Glu Tyr Val Ala Ser Leu His 
                485                 490                 495     


Leu Pro Ser Phe Asp Ala His Leu Thr Glu Leu Thr Asp Asp Gln Ala 
            500                 505                 510         


Lys Tyr Leu Gly Leu Asn Lys Asn Gly Pro Phe Lys Pro Asn Tyr Tyr 
        515                 520                 525             


Arg Tyr 
    530 


<210>  5
<211>  585
<212>  PRT
<213>  Mus musculus

<400>  5

Met Ala Thr Cys Trp Gln Ala Leu Trp Ala Tyr Arg Ser Tyr Leu Ile 
1               5                   10                  15      


Val Leu Cys Leu Pro Ile Phe Leu Leu Pro Leu Pro Leu Ile Val Gln 
            20                  25                  30          


Thr Lys Glu Ala Tyr Cys Ala Tyr Ser Ile Ile Leu Met Ala Leu Leu 
        35                  40                  45              


Trp Cys Thr Glu Ala Leu Pro Leu Ala Val Thr Ala Leu Phe Pro Ile 
    50                  55                  60                  


Ile Leu Phe Pro Leu Met Gly Ile Met Glu Ala Ser Lys Val Cys Leu 
65                  70                  75                  80  


Glu Tyr Phe Lys Asp Thr Asn Ile Leu Phe Val Gly Gly Leu Met Val 
                85                  90                  95      


Ala Ile Ala Val Glu His Trp Asn Leu His Lys Arg Ile Ala Leu Gly 
            100                 105                 110         


Val Leu Leu Ile Ile Gly Val Arg Pro Ala Leu Leu Leu Leu Gly Phe 
        115                 120                 125             


Met Leu Val Thr Ala Phe Leu Ser Met Trp Ile Ser Asn Thr Ala Thr 
    130                 135                 140                 


Thr Ala Met Met Leu Pro Ile Gly Tyr Ala Val Leu Glu Gln Leu Gln 
145                 150                 155                 160 


Gly Ser Gln Lys Asp Val Glu Glu Gly Asn Ser Asn Pro Ser Phe Glu 
                165                 170                 175     


Leu Gln Glu Ala Ser Pro Gln Lys Glu Glu Thr Lys Leu Asp Asn Gly 
            180                 185                 190         


Gln Ala Val Ser Val Ser Ser Glu Pro Arg Ala Gln Lys Thr Lys Glu 
        195                 200                 205             


His His Arg Phe Ser Gln Gly Leu Ser Leu Cys Ile Cys Tyr Ser Ala 
    210                 215                 220                 


Ser Ile Gly Gly Ile Ala Thr Leu Thr Gly Thr Thr Pro Asn Leu Val 
225                 230                 235                 240 


Leu Gln Gly Gln Val Asn Ser Ile Phe Pro Glu Asn Ser Asn Val Val 
                245                 250                 255     


Asn Phe Ala Ser Trp Phe Gly Phe Ala Phe Pro Thr Met Val Ile Leu 
            260                 265                 270         


Leu Leu Leu Ala Trp Leu Trp Leu Gln Val Leu Phe Leu Gly Val Asn 
        275                 280                 285             


Phe Arg Lys Asn Phe Gly Phe Gly Glu Gly Glu Glu Glu Arg Lys Gln 
    290                 295                 300                 


Ala Ala Phe Gln Val Ile Lys Thr Gln His Arg Leu Leu Gly Pro Met 
305                 310                 315                 320 


Ser Phe Ala Glu Lys Ala Val Thr Phe Leu Phe Val Leu Leu Val Val 
                325                 330                 335     


Leu Trp Phe Thr Arg Glu Pro Gly Phe Phe Pro Gly Trp Gly Asp Thr 
            340                 345                 350         


Ala Phe Ala Asn Lys Gly Gln Ser Met Val Ser Asp Gly Thr Val Ala 
        355                 360                 365             


Ile Phe Ile Ser Leu Ile Met Phe Ile Ile Pro Ser Lys Ile Pro Gly 
    370                 375                 380                 


Leu Thr Glu Asp Pro Lys Lys Pro Gly Lys Leu Lys Ala Pro Pro Ala 
385                 390                 395                 400 


Ile Leu Thr Trp Lys Thr Val Asn Asp Lys Met Pro Trp Asn Ile Leu 
                405                 410                 415     


Ile Leu Leu Gly Gly Gly Phe Ala Leu Ala Lys Gly Ser Glu Glu Ser 
            420                 425                 430         


Gly Leu Ser Lys Trp Leu Gly Asp Lys Leu Thr Pro Leu Gln His Val 
        435                 440                 445             


Pro Pro Ser Ala Thr Val Leu Ile Leu Ser Leu Leu Val Ala Ile Phe 
    450                 455                 460                 


Thr Glu Cys Thr Ser Asn Val Ala Thr Thr Thr Leu Phe Leu Pro Ile 
465                 470                 475                 480 


Leu Ala Ser Met Ala Gln Ala Ile Cys Leu His Pro Leu Tyr Val Met 
                485                 490                 495     


Leu Pro Cys Thr Leu Ala Ala Ser Leu Ala Phe Met Leu Pro Val Ala 
            500                 505                 510         


Thr Pro Pro Asn Ala Ile Val Phe Ser Phe Gly Gly Leu Lys Val Ser 
        515                 520                 525             


Asp Met Ala Arg Ala Gly Phe Leu Leu Asn Ile Ile Gly Val Leu Thr 
    530                 535                 540                 


Ile Thr Leu Ser Ile Asn Ser Trp Ser Ile Pro Ile Phe Lys Leu Asp 
545                 550                 555                 560 


Thr Phe Pro Thr Trp Ala Tyr Ser Asn Thr Ser Gln Cys Leu Leu Asn 
                565                 570                 575     


Pro Pro Asn Ser Thr Val Pro Gly His 
            580                 585 


<210>  6
<211>  641
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Thr Cys Trp Gln Ala Leu Trp Ala Tyr Arg Ser Tyr Leu Ile 
1               5                   10                  15      


Val Phe Phe Val Pro Ile Leu Leu Leu Pro Leu Pro Ile Leu Val Pro 
            20                  25                  30          


Ser Lys Glu Ala Tyr Cys Ala Tyr Ala Ile Ile Leu Met Ala Leu Phe 
        35                  40                  45              


Trp Cys Thr Glu Ala Leu Pro Leu Ala Val Thr Ala Leu Phe Pro Leu 
    50                  55                  60                  


Ile Leu Phe Pro Met Met Gly Ile Val Asp Ala Ser Glu Ile Ile Gln 
65                  70                  75                  80  


Arg Pro Phe Pro Ser Ser Phe Glu Ser Pro Gly Glu Cys Gln Ser Val 
                85                  90                  95      


Gly Met Ser Val Thr Ala Ser His Asn Leu Gly Gly Thr Val Gly Asp 
            100                 105                 110         


Ser Arg Val Phe Pro Pro Leu Ser His Val Ser Thr Cys Gln Val Ala 
        115                 120                 125             


Val Glu Tyr Leu Lys Asp Ser Asn Leu Leu Phe Phe Gly Gly Leu Leu 
    130                 135                 140                 


Val Ala Ile Ala Val Glu His Trp Asn Leu His Lys Arg Ile Ala Leu 
145                 150                 155                 160 


Arg Val Leu Leu Ile Val Gly Val Arg Pro Ala Pro Leu Ile Leu Gly 
                165                 170                 175     


Phe Met Leu Val Thr Ala Phe Leu Ser Met Trp Ile Ser Asn Thr Ala 
            180                 185                 190         


Thr Ser Ala Met Met Val Pro Ile Ala His Ala Val Leu Asp Gln Leu 
        195                 200                 205             


His Ser Ser Gln Ala Ser Ser Asn Val Glu Glu Gly Ser Asn Asn Pro 
    210                 215                 220                 


Thr Phe Glu Leu Gln Glu Pro Ser Pro Gln Lys Glu Val Thr Lys Leu 
225                 230                 235                 240 


Asp Asn Gly Gln Ala Leu Pro Val Thr Ser Ala Ser Ser Glu Gly Arg 
                245                 250                 255     


Ala His Leu Ser Gln Lys His Leu His Leu Thr Gln Cys Met Ser Leu 
            260                 265                 270         


Cys Val Cys Tyr Ser Ala Ser Ile Gly Gly Ile Ala Thr Leu Thr Gly 
        275                 280                 285             


Thr Ala Pro Asn Leu Val Leu Gln Gly Gln Ile Asn Ser Leu Phe Pro 
    290                 295                 300                 


Gln Asn Gly Asn Val Val Asn Phe Ala Ser Trp Phe Ser Phe Ala Phe 
305                 310                 315                 320 


Pro Thr Met Val Ile Leu Leu Leu Leu Ala Trp Leu Trp Leu Gln Ile 
                325                 330                 335     


Leu Phe Leu Gly Phe Asn Phe Arg Lys Asn Phe Gly Ile Gly Glu Lys 
            340                 345                 350         


Met Gln Glu Gln Gln Gln Ala Ala Tyr Cys Val Ile Gln Thr Glu His 
        355                 360                 365             


Arg Leu Leu Gly Pro Met Thr Phe Ala Glu Lys Ala Ile Ser Ile Leu 
    370                 375                 380                 


Phe Val Ile Leu Val Leu Leu Trp Phe Thr Arg Glu Pro Gly Phe Phe 
385                 390                 395                 400 


Leu Gly Trp Gly Asn Leu Ala Phe Pro Asn Ala Lys Gly Glu Ser Met 
                405                 410                 415     


Val Ser Asp Gly Thr Val Ala Ile Phe Ile Gly Ile Ile Met Phe Ile 
            420                 425                 430         


Ile Pro Ser Lys Phe Pro Gly Leu Thr Gln Asp Pro Glu Asn Pro Gly 
        435                 440                 445             


Lys Leu Lys Ala Pro Leu Gly Leu Leu Asp Trp Lys Thr Val Asn Gln 
    450                 455                 460                 


Lys Met Pro Trp Asn Ile Val Leu Leu Leu Gly Gly Gly Tyr Ala Leu 
465                 470                 475                 480 


Ala Lys Gly Ser Glu Arg Ser Gly Leu Ser Glu Trp Leu Gly Asn Lys 
                485                 490                 495     


Leu Thr Pro Leu Gln Ser Val Pro Ala Pro Ala Ile Ala Ile Ile Leu 
            500                 505                 510         


Ser Leu Leu Val Ala Thr Phe Thr Glu Cys Thr Ser Asn Val Ala Thr 
        515                 520                 525             


Thr Thr Ile Phe Leu Pro Ile Leu Ala Ser Met Ala Gln Ala Ile Cys 
    530                 535                 540                 


Leu His Pro Leu Tyr Val Met Leu Pro Cys Thr Leu Ala Thr Ser Leu 
545                 550                 555                 560 


Ala Phe Met Leu Pro Val Ala Thr Pro Pro Asn Ala Ile Val Phe Ser 
                565                 570                 575     


Phe Gly Asp Leu Lys Val Leu Asp Met Ala Arg Ala Gly Phe Leu Leu 
            580                 585                 590         


Asn Ile Ile Gly Val Leu Ile Ile Ala Leu Ala Ile Asn Ser Trp Gly 
        595                 600                 605             


Ile Pro Leu Phe Ser Leu His Ser Phe Pro Ser Trp Ala Gln Ser Asn 
    610                 615                 620                 


Thr Thr Ala Gln Cys Leu Pro Ser Leu Ala Asn Thr Thr Thr Pro Ser 
625                 630                 635                 640 


Pro 
    


<210>  7
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Leu Gly Ile Met Ala Trp Asn Ala Thr Cys Lys Asn Trp Leu Ala 
1               5                   10                  15      


Ala Glu Ala Ala Leu Glu Lys Tyr Tyr Leu Ser Ile Phe Tyr Gly Ile 
            20                  25                  30          


Glu Phe Val Val Gly Val Leu Gly Asn Thr Ile Val Val Tyr Gly Tyr 
        35                  40                  45              


Ile Phe Ser Leu Lys Asn Trp Asn Ser Ser Asn Ile Tyr Leu Phe Asn 
    50                  55                  60                  


Leu Ser Val Ser Asp Leu Ala Phe Leu Cys Thr Leu Pro Met Leu Ile 
65                  70                  75                  80  


Arg Ser Tyr Ala Asn Gly Asn Trp Ile Tyr Gly Asp Val Leu Cys Ile 
                85                  90                  95      


Ser Asn Arg Tyr Val Leu His Ala Asn Leu Tyr Thr Ser Ile Leu Phe 
            100                 105                 110         


Leu Thr Phe Ile Ser Ile Asp Arg Tyr Leu Ile Ile Lys Tyr Pro Phe 
        115                 120                 125             


Arg Glu His Leu Leu Gln Lys Lys Glu Phe Ala Ile Leu Ile Ser Leu 
    130                 135                 140                 


Ala Ile Trp Val Leu Val Thr Leu Glu Leu Leu Pro Ile Leu Pro Leu 
145                 150                 155                 160 


Ile Asn Pro Val Ile Thr Asp Asn Gly Thr Thr Cys Asn Asp Phe Ala 
                165                 170                 175     


Ser Ser Gly Asp Pro Asn Tyr Asn Leu Ile Tyr Ser Met Cys Leu Thr 
            180                 185                 190         


Leu Leu Gly Phe Leu Ile Pro Leu Phe Val Met Cys Phe Phe Tyr Tyr 
        195                 200                 205             


Lys Ile Ala Leu Phe Leu Lys Gln Arg Asn Arg Gln Val Ala Thr Ala 
    210                 215                 220                 


Leu Pro Leu Glu Lys Pro Leu Asn Leu Val Ile Met Ala Val Val Ile 
225                 230                 235                 240 


Phe Ser Val Leu Phe Thr Pro Tyr His Val Met Arg Asn Val Arg Ile 
                245                 250                 255     


Ala Ser Arg Leu Gly Ser Trp Lys Gln Tyr Gln Cys Thr Gln Val Val 
            260                 265                 270         


Ile Asn Ser Phe Tyr Ile Val Thr Arg Pro Leu Ala Phe Leu Asn Ser 
        275                 280                 285             


Val Ile Asn Pro Val Phe Tyr Phe Leu Leu Gly Asp His Phe Arg Asp 
    290                 295                 300                 


Met Leu Met Asn Gln Leu Arg His Asn Phe Lys Ser Leu Thr Ser Phe 
305                 310                 315                 320 


Ser Arg Trp Ala His Glu Leu Leu Leu Ser Phe Arg Glu Lys 
                325                 330                 


<210>  8
<211>  1005
<212>  DNA
<213>  Homo sapiens

<400>  8
atgctgggga tcatggcatg gaatgcaact tgcaaaaact ggctggcagc agaggctgcc       60

ctggaaaagt actacctttc cattttttat gggattgagt tcgttgtggg agtccttgga      120

aataccattg ttgtttacgg ctacatcttc tctctgaaga actggaacag cagtaatatt      180

tatctcttta acctctctgt ctctgactta gcttttctgt gcaccctccc catgctgata      240

aggagttatg ccaatggaaa ctggatatat ggagacgtgc tctgcataag caaccgatat      300

gtgcttcatg ccaacctcta taccagcatt ctctttctca cttttatcag catagatcga      360

tacttgataa ttaagtatcc tttccgagaa caccttctgc aaaagaaaga gtttgctatt      420

ttaatctcct tggccatttg ggttttagta accttagagt tactacccat acttcccctt      480

ataaatcctg ttataactga caatggcacc acctgtaatg attttgcaag ttctggagac      540

cccaactaca acctcattta cagcatgtgt ctaacactgt tggggttcct tattcctctt      600

tttgtgatgt gtttctttta ttacaagatt gctctcttcc taaagcagag gaataggcag      660

gttgctactg ctctgcccct tgaaaagcct ctcaacttgg tcatcatggc agtggtaatc      720

ttctctgtgc tttttacacc ctatcacgtc atgcggaatg tgaggatcgc ttcacgcctg      780

gggagttgga agcagtatca gtgcactcag gtcgtcatca actcctttta cattgtgaca      840

cggcctttgg cctttctgaa cagtgtcatc aaccctgtct tctattttct tttgggagat      900

cacttcaggg acatgctgat gaatcaactg agacacaact tcaaatccct tacatccttt      960

agcagatggg ctcatgaact cctactttca ttcagagaaa agtga                     1005


<210>  9
<211>  60
<212>  PRT
<213>  Vibrio cholerae


<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa can be any naturally occurring amino acid

<400>  9

Ala Asn Ser Ile Ile Phe Leu Phe Leu Gly Gly Phe Ala Leu Ala Ala 
1               5                   10                  15      


Ala Xaa His His Gln Gly Leu Asp Lys Val Ile Ala Asp Lys Val Leu 
            20                  25                  30          


Ala Xaa Ala Gln Gly Lys Xaa Ser Val Ala Val Phe Xaa Leu Phe Gly 
        35                  40                  45              


Val Thr Ala Leu Leu Ser Xaa Trp Ile Ser Asn Thr 
    50                  55                  60  


<210>  10
<211>  60
<212>  PRT
<213>  Staphylococcus aureus

<400>  10

Gly Asn Asp Ile Ile Phe Leu Phe Leu Gly Gly Phe Ile Leu Ala Ile 
1               5                   10                  15      


Ala Met Glu Arg Trp Asn Leu His Thr Arg Val Ala Leu Thr Ile Ile 
            20                  25                  30          


Asn Leu Ile Gly Ala Ser Thr Ser Lys Ile Leu Leu Gly Phe Met Val 
        35                  40                  45              


Ala Thr Gly Phe Leu Ser Met Phe Val Ser Asn Thr 
    50                  55                  60  


<210>  11
<211>  60
<212>  PRT
<213>  Drosophila melanogaster

<400>  11

Phe Lys Asp Thr Leu Val Met Phe Met Gly Gly Ile Met Val Ala Leu 
1               5                   10                  15      


Ala Val Glu Tyr Cys Asn Leu His Lys Arg Leu Ala Leu Arg Val Ile 
            20                  25                  30          


Gln Ile Val Gly Cys Ser Pro Arg Arg Leu His Phe Gly Leu Ile Met 
        35                  40                  45              


Val Thr Met Phe Leu Ser Met Trp Ile Ser Asn Ala 
    50                  55                  60  


<210>  12
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  12

Leu Lys Asp Ser Asn Leu Leu Phe Phe Gly Gly Leu Leu Val Ala Ile 
1               5                   10                  15      


Ala Val Glu His Trp Asn Leu His Lys Arg Ile Ala Leu Arg Val Leu 
            20                  25                  30          


Leu Ile Val Gly Val Arg Pro Ala Pro Leu Ile Leu Gly Phe Met Leu 
        35                  40                  45              


Val Thr Ala Phe Leu Ser Met Trp Ile Ser Asn Thr 
    50                  55                  60  


<210>  13
<211>  61
<212>  PRT
<213>  Mus musculus

<400>  13

Phe Lys Asp Thr Asn Ile Leu Phe Val Gly Gly Leu Met Val Ala Ile 
1               5                   10                  15      


Ala Val Glu His Trp Asn Leu His Lys Arg Ile Ala Leu Gly Val Ile 
            20                  25                  30          


Leu Leu Ile Ile Gly Val Arg Pro Ala Leu Leu Leu Leu Gly Phe Met 
        35                  40                  45              


Leu Val Thr Ala Phe Leu Ser Met Trp Ile Ser Asn Thr 
    50                  55                  60      


<210>  14
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  14

Phe Leu Asp Thr Asn Phe Leu Phe Leu Ser Gly Leu Ile Met Ala Ser 
1               5                   10                  15      


Ala Ile Glu Glu Trp Asn Leu His Arg Arg Ile Ala Leu Lys Ile Leu 
            20                  25                  30          


Met Leu Val Gly Val Gln Pro Ala Arg Leu Ile Leu Gly Met Met Val 
        35                  40                  45              


Thr Thr Ser Phe Leu Ser Met Trp Leu Ser Asn Thr 
    50                  55                  60  


<210>  15
<211>  60
<212>  PRT
<213>  Mus musculus

<400>  15

Phe Leu Asp Thr Asn Phe Leu Phe Leu Ser Gly Leu Ile Met Ala Ser 
1               5                   10                  15      


Ala Ile Glu Glu Trp Asn Leu His Arg Arg Ile Ala Leu Lys Val Leu 
            20                  25                  30          


Met Leu Val Gly Val Gln Pro Ala Arg Leu Ile Leu Gly Met Met Val 
        35                  40                  45              


Thr Thr Ser Phe Leu Ser Met Trp Leu Ser Asn Thr 
    50                  55                  60  


<210>  16
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Lys Asp Thr Asn Met Leu Phe Leu Gly Gly Leu Ile Val Ala Val 
1               5                   10                  15      


Ala Val Glu Arg Trp Asn Leu His Lys Arg Ile Ala Leu Arg Thr Leu 
            20                  25                  30          


Leu Trp Val Gly Ala Lys Pro Ala Arg Leu Met Leu Gly Phe Met Gly 
        35                  40                  45              


Val Thr Ala Leu Leu Ser Met Trp Ile Ser Asn Thr 
    50                  55                  60  


<210>  17
<211>  60
<212>  PRT
<213>  Mus musculus

<400>  17

Met Lys Asp Thr Asn Met Leu Phe Leu Gly Ser Leu Ile Val Ala Val 
1               5                   10                  15      


Ala Val Glu Arg Trp Lys Leu His Lys Arg Val Ala Leu Arg Met Leu 
            20                  25                  30          


Leu Phe Val Gly Thr Lys Pro Ser Arg Leu Met Leu Gly Phe Met Phe 
        35                  40                  45              


Val Thr Ala Phe Leu Ser Met Trp Ile Ser Asn Thr 
    50                  55                  60  


<210>  18
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  18

Phe Lys Asp Phe His Leu Leu Leu Ile Gly Val Ile Cys Leu Ala Thr 
1               5                   10                  15      


Ser Ile Glu Lys Trp Asn Leu His Lys Arg Ile Ala Leu Lys Met Val 
            20                  25                  30          


Met Met Val Gly Val Asn Pro Ala Trp Leu Thr Leu Gly Phe Met Ser 
        35                  40                  45              


Ser Thr Ala Phe Leu Ser Met Trp Leu Ser Asn Thr 
    50                  55                  60  


<210>  19
<211>  60
<212>  PRT
<213>  Mus musculus

<400>  19

Phe Lys Asp Phe His Leu Leu Leu Ile Val Gly Ile Cys Leu Ala Thr 
1               5                   10                  15      


Ser Ile Glu Lys Trp Asn Leu His Lys Arg Ile Ala Leu Arg Met Val 
            20                  25                  30          


Met Met Val Gly Val Asn Pro Ala Trp Leu Thr Leu Gly Phe Met Ser 
        35                  40                  45              


Ser Thr Ala Phe Leu Ser Met Trp Leu Ser Asn Thr 
    50                  55                  60  


<210>  20
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  20

Phe Lys Asn Thr Thr Leu Leu Leu Val Gly Val Ile Cys Val Ala Ala 
1               5                   10                  15      


Ala Val Glu Lys Trp Asn Leu His Lys Arg Ile Ala Leu Arg Met Val 
            20                  25                  30          


Leu Met Ala Gly Ala Lys Pro Gly Met Leu Leu Leu Cys Phe Met Cys 
        35                  40                  45              


Cys Thr Thr Leu Leu Ser Met Trp Leu Ser Asn Thr 
    50                  55                  60  


<210>  21
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  21

Glu Glu Lys Leu Arg Lys Gln Ala Ala Ser Pro Lys Gly Ala Ser Val 
1               5                   10                  15      


Ser Ile Asn Val Asn Thr Ser Leu Glu Asp Met Arg Ser Asn Asn Val 
            20                  25                  30          


Glu Asp Cys Lys Met Met Gln Val Ser Ser Gly Asp Lys Met Glu Asp 
        35                  40                  45              


Ala Thr Ala Asn Gly Gln Glu Asp Ser Lys Ala Pro Asp Gly Ser 
    50                  55                  60              


<210>  22
<211>  62
<212>  PRT
<213>  Mus musculus

<400>  22

Ala Lys Lys Ser Gln Lys Gln Asp Ala Ser Ser Lys Ile Ser Ser Val 
1               5                   10                  15      


Ser Val Asn Val Asn Thr Asn Leu Glu Asp Val Lys Ser Asn Asp Val 
            20                  25                  30          


Glu Gly Ser Glu Ala Lys Val His Gln Gly Glu Glu Leu Gln Asp Val 
        35                  40                  45              


Val Ser Ser Asn Gln Glu Asp Ala Lys Ala Pro Thr Met Thr 
    50                  55                  60          


<210>  23
<211>  57
<212>  PRT
<213>  Sus scrofa

<400>  23

Gly Asn Lys Leu Val Lys Lys Asp Thr Ser Ile Ser Ile Asn Val Asn 
1               5                   10                  15      


Thr Gly Ile Thr Asn Ile Glu Ser Asn Asp Val Glu Gly Ser Asn Val 
            20                  25                  30          


Lys Val Ser Ala Glu Lys Glu Leu Glu Asp Ile Ala Ala Gly Asp Gln 
        35                  40                  45              


Glu Asp Ala Lys Ala Pro Ala Met Ser 
    50                  55          


