                         SEQUENCE LISTING

<110>  King's College London
 
<120>  Compositions and methods for enhancing gamma-delta T cells in 
       the gut

<130>  NRS/LP7404700

<140>  
<141>  2018-09-17

<150>  US62/559,225
<151>  201-09-15

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Phe Val Leu Ile Leu Val Leu Ser Phe Tyr Glu Leu Val Ser 
1               5                   10                  15      


Gly Gln Trp Gln Val Thr Gly Pro Gly Lys Phe Val Gln Ala Leu Val 
            20                  25                  30          


Gly Glu Asp Ala Val Phe Ser Cys Ser Leu Phe Pro Glu Thr Ser Ala 
        35                  40                  45              


Glu Ala Met Glu Val Arg Phe Phe Arg Asn Gln Phe His Ala Val Val 
    50                  55                  60                  


His Leu Tyr Arg Asp Gly Glu Asp Trp Glu Ser Lys Gln Met Pro Gln 
65                  70                  75                  80  


Tyr Arg Gly Arg Thr Glu Phe Val Lys Asp Ser Ile Ala Gly Gly Arg 
                85                  90                  95      


Val Ser Leu Arg Leu Lys Asn Ile Thr Pro Ser Asp Ile Gly Leu Tyr 
            100                 105                 110         


Gly Cys Trp Phe Ser Ser Gln Ile Tyr Asp Glu Glu Ala Thr Trp Glu 
        115                 120                 125             


Leu Arg Val Ala Ala Leu Gly Ser Leu Pro Leu Ile Ser Ile Val Gly 
    130                 135                 140                 


Tyr Val Asp Gly Gly Ile Gln Leu Leu Cys Leu Ser Ser Gly Trp Phe 
145                 150                 155                 160 


Pro Gln Pro Thr Ala Lys Trp Lys Gly Pro Gln Gly Gln Asp Leu Ser 
                165                 170                 175     


Ser Asp Ser Arg Ala Asn Ala Asp Gly Tyr Ser Leu Tyr Asp Val Glu 
            180                 185                 190         


Ile Ser Ile Ile Val Gln Glu Asn Ala Gly Ser Ile Leu Cys Ser Ile 
        195                 200                 205             


His Leu Ala Glu Gln Ser His Glu Val Glu Ser Lys Val Leu Ile Gly 
    210                 215                 220                 


Glu Thr Phe Phe Gln Pro Ser Pro Trp Arg Leu Ala Ser Ile Leu Leu 
225                 230                 235                 240 


Gly Leu Leu Cys Gly Ala Leu Cys Gly Val Val Met Gly Met Ile Ile 
                245                 250                 255     


Val Phe Phe Lys Ser Lys Gly Lys Ile Gln Ala Glu Leu Asp Trp Arg 
            260                 265                 270         


Arg Lys His Gly Gln Ala Glu Leu Arg Asp Ala Arg Lys His Ala Val 
        275                 280                 285             


Glu Val Thr Leu Asp Pro Glu Thr Ala His Pro Lys Leu Cys Val Ser 
    290                 295                 300                 


Asp Leu Lys Thr Val Thr His Arg Lys Ala Pro Gln Glu Val Pro His 
305                 310                 315                 320 


Ser Glu Lys Arg Phe Thr Arg Lys Ser Val Val Ala Ser Gln Gly Phe 
                325                 330                 335     


Gln Ala Gly Lys His Tyr Trp Glu Val Asp Val Gly Gln Asn Val Gly 
            340                 345                 350         


Trp Tyr Val Gly Val Cys Arg Asp Asp Val Asp Arg Gly Lys Asn Asn 
        355                 360                 365             


Val Thr Leu Ser Pro Asn Asn Gly Tyr Trp Val Leu Arg Leu Thr Thr 
    370                 375                 380                 


Glu His Leu Tyr Phe Thr Phe Asn Pro His Phe Ile Ser Leu Pro Pro 
385                 390                 395                 400 


Ser Thr Pro Pro Thr Arg Val Gly Val Phe Leu Asp Tyr Glu Gly Gly 
                405                 410                 415     


Thr Ile Ser Phe Phe Asn Thr Asn Asp Gln Ser Leu Ile Tyr Thr Leu 
            420                 425                 430         


Leu Thr Cys Gln Phe Glu Gly Leu Leu Arg Pro Tyr Ile Gln His Ala 
        435                 440                 445             


Met Tyr Asp Glu Glu Lys Gly Thr Pro Ile Phe Ile Cys Pro Val Ser 
    450                 455                 460                 


Trp Gly 
465     


<210>  2
<211>  2454
<212>  RNA
<213>  Homo sapiens

<400>  2
cauacuccuc auucauacag ccauguuuag ggaggcucua gggagaaaug cacaguuuga       60

caucguucau gaagagccuc uccacggcuc cugcgccuga gacagcuggc cugaccucca      120

aaucauccau ccaccccugc ugucaucugu uuucauagug ugagaucaac ccacaggaau      180

auccauggcu uuugugcuca uuuugguucu caguuucuac gagcuggugu caggacagug      240

gcaagucacu ggaccgggca aguuugucca ggccuuggug ggggaggacg ccguguucuc      300

cugcucccuc uuuccugaga ccagugcaga ggcuauggaa gugcgguucu ucaggaauca      360

guuccaugcu gugguccacc ucuacagaga uggggaagac ugggaaucua agcagaugcc      420

acaguaucga gggagaacug aguuugugaa ggacuccauu gcaggggggc gugucucucu      480

aaggcuaaaa aacaucacuc ccucggacau cggccuguau gggugcuggu ucaguuccca      540

gauuuacgau gaggaggcca ccugggagcu gcggguggca gcacugggcu cacuuccucu      600

cauuuccauc gugggauaug uugacggagg uauccaguua cucugccugu ccucaggcug      660

guucccccag cccacagcca aguggaaagg uccacaagga caggauuugu cuucagacuc      720

cagagcaaau gcagaugggu acagccugua ugauguggag aucuccauua uaguccagga      780

aaaugcuggg agcauauugu guuccaucca ccuugcugag cagagucaug agguggaauc      840

caagguauug auaggagaga cguuuuucca gcccucaccu uggcgccugg cuucuauuuu      900

acucggguua cucuguggug cccugugugg uguugucaug gggaugauaa uuguuuucuu      960

caaauccaaa gggaaaaucc aggcggaacu ggacuggaga agaaagcacg gacaggcaga     1020

auugagagac gcccggaaac acgcagugga ggugacucug gauccagaga cggcucaccc     1080

gaagcucugc guuucugauc ugaaaacugu aacccauaga aaagcucccc aggaggugcc     1140

ucacucugag aagagauuua caaggaagag ugugguggcu ucucaggguu uccaagcagg     1200

gaaacauuac ugggaggugg acgugggaca aaauguaggg ugguaugugg gagugugucg     1260

ggaugacgua gacaggggga agaacaaugu gacuuugucu cccaacaaug gguauugggu     1320

ccucagacug acaacagaac auuuguauuu cacauucaau ccccauuuua ucagccuccc     1380

ccccagcacc ccuccuacac gaguaggggu cuuccuggac uaugagggug ggaccaucuc     1440

cuucuucaau acaaaugacc agucccuuau uuauacccug cugacauguc aguuugaagg     1500

cuuguugaga cccuauaucc agcaugcgau guaugacgag gaaaagggga cucccauauu     1560

cauaugucca guguccuggg gaugagacag agaagacccu gcuuaaaggg ccccacacca     1620

cagacccaga cacagccaag ggagagugcu cccgacaggu ggccccagcu uccucuccgg     1680

agccugcgca cagagaguca cgccccccac ucuccuuuag ggagcugagg uucuucugcc     1740

cugagcccug cagcagcggc agucacagcu uccagaugag gggggauugg ccugacccug     1800

ugggagucag aagccauggc ugcccugaag uggggacgga auagacucac auuagguuua     1860

guuugugaaa acuccaucca gcuaagcgau cuugaacaag ucacaaccuc ccaggcuccu     1920

cauuugcuag ucacggacag ugauuccugc cucacaggug aagauuaaag agacaacgaa     1980

ugugaaucau gcuugcaggu uugagggcac aguguuugcu aaugaugugu uuuuauauua     2040

uacauuuucc caccauaaac ucuguuugcu uauuccacau uaauuuacuu uucucuauac     2100

caaaucaccc auggaauagu uauugaacac cugcuuugug aggcucaaag aauaaagagg     2160

agguaggauu uuucacugau ucuauaagcc cagcauuacc ugauaccaaa accaggcaaa     2220

gaaaacagaa gaagaggaag gaaaacuaca gguccauauc ccucauuaac acagacacaa     2280

aaauucuaaa uaaaauuuua acaaauuaaa cuaaacaaua uauuuaaaga ugauauauaa     2340

cuacucagug ugguuugucc cacaaaugca gaguugguuu aauauuuaaa uaucaaccag     2400

uguaauucag cacauuaaua aaguaaaaaa gaaaaccaua aaaaaaaaaa aaaa           2454


<210>  3
<211>  509
<212>  PRT
<213>  Mus musculus

<400>  3

Met Met Lys Gly Ser Pro Ser Val Pro Pro Ala Gly Cys Leu Leu Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Phe Thr Gly Val Ser Gly Glu Val Ser Trp Phe 
            20                  25                  30          


Ser Val Lys Gly Pro Ala Glu Pro Ile Thr Val Leu Leu Gly Thr Glu 
        35                  40                  45              


Ala Thr Leu Pro Cys Gln Leu Ser Pro Glu Gln Ser Ala Ala Arg Met 
    50                  55                  60                  


His Ile Arg Trp Tyr Arg Ala Gln Pro Thr Pro Ala Val Leu Val Phe 
65                  70                  75                  80  


His Asn Gly Gln Glu Gln Gly Glu Val Gln Met Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Gln Met Val Arg Gln Ala Ile Asp Met Gly Ser Val Ala Leu 
            100                 105                 110         


Gln Ile Gln Gln Val Gln Ala Ser Asp Asp Gly Leu Tyr His Cys Gln 
        115                 120                 125             


Phe Thr Asp Gly Phe Thr Ser Gln Glu Val Ser Met Glu Leu Arg Val 
    130                 135                 140                 


Ile Gly Leu Gly Ser Ala Pro Leu Val His Met Thr Gly Pro Glu Asn 
145                 150                 155                 160 


Asp Gly Ile Arg Val Leu Cys Ser Ser Ser Gly Trp Phe Pro Lys Pro 
                165                 170                 175     


Lys Val Gln Trp Arg Asp Thr Ser Gly Asn Met Leu Leu Ser Ser Ser 
            180                 185                 190         


Glu Leu Gln Thr Gln Asp Arg Glu Gly Leu Phe Gln Val Glu Val Ser 
        195                 200                 205             


Leu Leu Val Thr Asp Arg Ala Ile Gly Asn Val Ile Cys Ser Ile Gln 
    210                 215                 220                 


Asn Pro Met Tyr Asp Gln Glu Lys Ser Lys Ala Ile Leu Leu Pro Glu 
225                 230                 235                 240 


Pro Phe Phe Pro Lys Thr Cys Pro Trp Lys Val Ala Leu Val Cys Ser 
                245                 250                 255     


Val Leu Ile Leu Leu Val Leu Leu Gly Gly Ile Ser Leu Gly Ile Trp 
            260                 265                 270         


Lys Glu His Gln Val Lys Arg Arg Glu Ile Lys Lys Trp Ser Lys Glu 
        275                 280                 285             


His Glu Glu Met Leu Leu Leu Lys Lys Gly Thr Lys Ser Val Leu Lys 
    290                 295                 300                 


Ile Arg Asp Asp Leu Gln Ala Asp Leu Asp Arg Arg Lys Ala Leu Tyr 
305                 310                 315                 320 


Lys Glu Asp Trp Lys Lys Ala Leu Leu Tyr Pro Asp Trp Arg Lys Glu 
                325                 330                 335     


Leu Phe Gln Glu Ala Pro Val Arg Ile Asn Tyr Glu Met Pro Asp Gln 
            340                 345                 350         


Asp Lys Thr Asp Ser Arg Thr Glu Glu Asn Arg Gly Glu Glu Thr Val 
        355                 360                 365             


Ser Ser Ser Gln Val Asp His Asn Leu Ile Thr Leu Ser Gln Glu Gly 
    370                 375                 380                 


Phe Met Leu Gly Arg Tyr Tyr Trp Glu Val Asp Val Lys Asp Thr Glu 
385                 390                 395                 400 


Glu Trp Thr Leu Gly Val Tyr Glu Leu Cys Thr Gln Asp Ala Ser Leu 
                405                 410                 415     


Thr Asp Pro Leu Arg Lys Phe Arg Val Leu Glu Lys Asn Gly Asp Gly 
            420                 425                 430         


Tyr Arg Ala Leu Asp Phe Cys Ser Gln Asn Ile Asn Ser Glu Glu Pro 
        435                 440                 445             


Leu Gln Leu Lys Thr Arg Pro Leu Lys Ile Ala Ile Phe Leu Asp Gln 
    450                 455                 460                 


Glu Asp Asn Asp Leu Ser Phe Tyr Asn Met Thr Asp Glu Thr His Ile 
465                 470                 475                 480 


Phe Ser Phe Ala Gln Val Pro Phe Leu Gly Ser Pro Tyr Pro Tyr Phe 
                485                 490                 495     


Thr Arg Asn Ser Met Gly Leu Ser Ala Thr Ala Gln Pro 
            500                 505                 


<210>  4
<211>  2113
<212>  RNA
<213>  Mus musculus

<400>  4
acccuuaaau aagagcugaa gauggcugca gcuuucuccu agacuccucc aggagaaacu       60

cuaaagccag agccuggggg cagcauugug uguccaccuu gccacugaga acaucuacgg      120

aaauuggaca cucuggcccc agcauccaca cgcuugacug uuggccacag uaacacaggu      180

guggaugguc cccagagcca ggguccagga gugcacugag gaucccuggg gcuucaagga      240

acccacagcu cuguccagac gggaauuuuu uuccugagaa cuuucaccug uugcccuccu      300

auggugaacc uggacuugac cuuccacucu gaugaugaag ggcucccccu ccgucccucc      360

agcugguugu cuccucccuc ugcuccuccu gcuguuuacc ggagucucug gagaaguguc      420

uugguuuucu gugaagggac cagcugagcc caucacuguc cugcugggga cugaagccac      480

ccugcccugc cagcugucuc cugaacagag ugcagcucgc augcacaucc gaugguaccg      540

ugcccagccc accccugcug ugcugguguu ccacaacgga caggagcagg gagaggugca      600

gaugccggaa uacaggggca ggacccagau ggugagacaa gccauugaca ugggaagugu      660

ggcucugcag auacagcagg uccaggccuc ugaugauggc cuguaccacu gucaguuuac      720

agauggcuuc accucccaag aggucuccau ggagcuucga gucauagguu uaggcucugc      780

cccucuuguu cacaugacag gaccugagaa ugaugggauc cgaguguugu gcuccucaag      840

uggcugguuc ccaaaaccca aagugcaaug gagagacacc uccgggaaca ugcuacuguc      900

cuccucugag uugcagaccc aagacagaga agggcucuuc cagguggaag ugucucuuuu      960

ggucacagau agagcuauug gcaaugugau cugcuccauc caaaauccca uguaugacca     1020

ggagaaaucg aaggccaucc uccucccaga gcccuucuuc cccaagacgu guccauggaa     1080

aguagcccug guuuguucug uccucauacu auugguccug cucgguggga ucagccuugg     1140

aaucuggaaa gaacaucaag ucaaaaggag agaaauuaaa aaauggucaa aggaacauga     1200

agaaaugcuu cuguugaaga aggggacaaa aucuguacug aagaucagag augaccucca     1260

ggccgaccua gaucggagga aggcgcugua caaagaagac uggaagaagg ccuugcugua     1320

cccugacugg aggaaggagc uguuccagga ggcuccugug aggauaaauu augaaaugcc     1380

ugaccaggac aagacagacu caaggacaga agagaacaga ggugaggaga cugucagcag     1440

cucacaagua gaccacaacc ucaucacacu cucccaggaa ggcuucaugu ugggaagaua     1500

cuacugggag guggauguca aggacacaga ggaguggaca cuaggaguuu augagcugug     1560

cacucaggau gcaucacuua cagaccccuu gaggaaauuc agaguccugg aaaagaaugg     1620

agauggauac agggcucuug acuucuguuc ccaaaacauu aauucggaag aaccucugca     1680

acugaagaca cguccgcuga agaucgccau cuucuuggau caggaagaca augaccucuc     1740

uuucuacaac augaccgaug agacacacau cuuuuccuuu gcccaggucc cuuucuuggg     1800

aucacccuau ccuuacuuca cacguaauuc cauggggcuc ucugcaacag cacagcccua     1860

agugaugugc acagggaauu caaugggugg gugcugcagc gugcuacccg uaaggcccuc     1920

uuaggcaggc acagggggcc ucugaccaag aggccucuua accugagacu ccaugagccu     1980

cggggaucag auccuggaca agauucucgg accaucugug ucgugcaugg uguuauaguu     2040

auuaauagcc uuccuucuuu ugacaaaaau guguuuaauc auuccuaaga uaaaugaauc     2100

cauggcuuuc uga                                                        2113


<210>  5
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Leu Met Leu Ser Leu Val Leu Ser Leu Leu Lys Leu Gly Ser 
1               5                   10                  15      


Gly Gln Trp Gln Val Phe Gly Pro Asp Lys Pro Val Gln Ala Leu Val 
            20                  25                  30          


Gly Glu Asp Ala Ala Phe Ser Cys Phe Leu Ser Pro Lys Thr Asn Ala 
        35                  40                  45              


Glu Ala Met Glu Val Arg Phe Phe Arg Gly Gln Phe Ser Ser Val Val 
    50                  55                  60                  


His Leu Tyr Arg Asp Gly Lys Asp Gln Pro Phe Met Gln Met Pro Gln 
65                  70                  75                  80  


Tyr Gln Gly Arg Thr Lys Leu Val Lys Asp Ser Ile Ala Glu Gly Arg 
                85                  90                  95      


Ile Ser Leu Arg Leu Glu Asn Ile Thr Val Leu Asp Ala Gly Leu Tyr 
            100                 105                 110         


Gly Cys Arg Ile Ser Ser Gln Ser Tyr Tyr Gln Lys Ala Ile Trp Glu 
        115                 120                 125             


Leu Gln Val Ser Ala Leu Gly Ser Val Pro Leu Ile Ser Ile Thr Gly 
    130                 135                 140                 


Tyr Val Asp Arg Asp Ile Gln Leu Leu Cys Gln Ser Ser Gly Trp Phe 
145                 150                 155                 160 


Pro Arg Pro Thr Ala Lys Trp Lys Gly Pro Gln Gly Gln Asp Leu Ser 
                165                 170                 175     


Thr Asp Ser Arg Thr Asn Arg Asp Met His Gly Leu Phe Asp Val Glu 
            180                 185                 190         


Ile Ser Leu Thr Val Gln Glu Asn Ala Gly Ser Ile Ser Cys Ser Met 
        195                 200                 205             


Arg His Ala His Leu Ser Arg Glu Val Glu Ser Arg Val Gln Ile Gly 
    210                 215                 220                 


Asp Thr Phe Phe Glu Pro Ile Ser Trp His Leu Ala Thr Lys Val Leu 
225                 230                 235                 240 


Gly Ile Leu Cys Cys Gly Leu Phe Phe Gly Ile Val Gly Leu Lys Ile 
                245                 250                 255     


Phe Phe Ser Lys Phe Gln Trp Lys Ile Gln Ala Glu Leu Asp Trp Arg 
            260                 265                 270         


Arg Lys His Gly Gln Ala Glu Leu Arg Asp Ala Arg Lys His Ala Val 
        275                 280                 285             


Glu Val Thr Leu Asp Pro Glu Thr Ala His Pro Lys Leu Cys Val Ser 
    290                 295                 300                 


Asp Leu Lys Thr Val Thr His Arg Lys Ala Pro Gln Glu Val Pro His 
305                 310                 315                 320 


Ser Glu Lys Arg Phe Thr Arg Lys Ser Val Val Ala Ser Gln Ser Phe 
                325                 330                 335     


Gln Ala Gly Lys His Tyr Trp Glu Val Asp Gly Gly His Asn Lys Arg 
            340                 345                 350         


Trp Arg Val Gly Val Cys Arg Asp Asp Val Asp Arg Arg Lys Glu Tyr 
        355                 360                 365             


Val Thr Leu Ser Pro Asp His Gly Tyr Trp Val Leu Arg Leu Asn Gly 
    370                 375                 380                 


Glu His Leu Tyr Phe Thr Leu Asn Pro Arg Phe Ile Ser Val Phe Pro 
385                 390                 395                 400 


Arg Thr Pro Pro Thr Lys Ile Gly Val Phe Leu Asp Tyr Glu Cys Gly 
                405                 410                 415     


Thr Ile Ser Phe Phe Asn Ile Asn Asp Gln Ser Leu Ile Tyr Thr Leu 
            420                 425                 430         


Thr Cys Arg Phe Glu Gly Leu Leu Arg Pro Tyr Ile Glu Tyr Pro Ser 
        435                 440                 445             


Tyr Asn Glu Gln Asn Gly Thr Pro Ile Val Ile Cys Pro Val Thr Gln 
    450                 455                 460                 


Glu Ser Glu Lys Glu Ala Ser Trp Gln Arg Ala Ser Ala Ile Pro Glu 
465                 470                 475                 480 


Thr Ser Asn Ser Glu Ser Ser Ser Gln Ala Thr Thr Pro Phe Leu Pro 
                485                 490                 495     


Arg Gly Glu Met 
            500 


<210>  6
<211>  2109
<212>  RNA
<213>  Homo sapiens

<400>  6
uagacauuua ugcagugguu caaagucuag agucccuaca cuucugguac augacagcug       60

ugucucgaug gaguagacuc ucagaacagc gcaguuugcc cuccgcucac gcagagccuc      120

uccguggcuu ccgcaccuug agcauuaggc caguucuccu cuucucucua auccauccgu      180

caccucuccu gucauccguu uccaugccgu gagguccauu cacagaacac auccauggcu      240

cucaugcuca guuugguucu gagucuccuc aagcugggau cagggcagug gcagguguuu      300

gggccagaca agccugucca ggccuuggug ggggaggacg cagcauucuc cuguuuccug      360

ucuccuaaga ccaaugcaga ggccauggaa gugcgguucu ucaggggcca guucucuagc      420

gugguccacc ucuacaggga cgggaaggac cagccauuua ugcagaugcc acaguaucaa      480

ggcaggacaa aacuggugaa ggauucuauu gcggaggggc gcaucucucu gaggcuggaa      540

aacauuacug uguuggaugc uggccucuau gggugcagga uuaguuccca gucuuacuac      600

cagaaggcca ucugggagcu acagguguca gcacugggcu caguuccucu cauuuccauc      660

acgggauaug uugauagaga cauccagcua cucugucagu ccucgggcug guucccccgg      720

cccacagcga aguggaaagg uccacaagga caggauuugu ccacagacuc caggacaaac      780

agagacaugc auggccuguu ugauguggag aucucucuga ccguccaaga gaacgccggg      840

agcauauccu guuccaugcg gcaugcucau cugagccgag agguggaauc caggguacag      900

auaggagaua ccuuuuucga gccuauaucg uggcaccugg cuaccaaagu acugggaaua      960

cucugcugug gccuauuuuu uggcauuguu ggacugaaga uuuucuucuc caaauuccag     1020

uggaaaaucc aggcggaacu ggacuggaga agaaagcacg gacaggcaga auugagagac     1080

gcccggaaac acgcagugga ggugacucug gauccagaga cggcucaccc gaagcucugc     1140

guuucugauc ugaaaacugu aacccauaga aaagcucccc aggaggugcc ucacucugag     1200

aagagauuua caaggaagag ugugguggcu ucucagaguu uccaagcagg gaaacauuac     1260

ugggaggugg acggaggaca caauaaaagg uggcgcgugg gagugugccg ggaugaugug     1320

gacaggagga aggaguacgu gacuuugucu cccgaucaug gguacugggu ccucagacug     1380

aauggagaac auuuguauuu cacauuaaau ccccguuuua ucagcgucuu ccccaggacc     1440

ccaccuacaa aaauaggggu cuuccuggac uaugagugug ggaccaucuc cuucuucaac     1500

auaaaugacc agucccuuau uuauacccug acaugucggu uugaaggcuu auugaggccc     1560

uacauugagu auccguccua uaaugagcaa aauggaacuc ccauagucau cugcccaguc     1620

acccaggaau cagagaaaga ggccucuugg caaagggccu cugcaauccc agagacaagc     1680

aacagugagu ccuccucaca ggcaaccacg cccuuccucc ccagggguga aauguaggau     1740

gaaucacauc ccacauucuu cuuuagggau auuaaggucu cucucccaga uccaaagucc     1800

cgcagcagcc ggccaaggug gcuuccagau gaagggggac uggccugucc acaugggagu     1860

caggugucau ggcugcccug agcugggagg gaagaaggcu gacauuacau uuaguuugcu     1920

cucacuccau cuggcuaagu gaucuugaaa uaccaccucu caggugaaga accgucagga     1980

auucccaucu cacaggcugu gguguagauu aaguagacaa ggaaugugaa uaaugcuuag     2040

aucuuauuga ugacagagug uauccuaaug guuuguucau uauauuacac uuucaguaaa     2100

aaaaaaaaa                                                             2109


<210>  7
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Leu Met Leu Ser Leu Val Leu Ser Leu Leu Lys Leu Gly Ser 
1               5                   10                  15      


Gly Gln Trp Gln Val Phe Gly Pro Asp Lys Pro Val Gln Ala Leu Val 
            20                  25                  30          


Gly Glu Asp Ala Ala Phe Ser Cys Phe Leu Ser Pro Lys Thr Asn Ala 
        35                  40                  45              


Glu Ala Met Glu Val Arg Phe Phe Arg Gly Gln Phe Ser Ser Val Val 
    50                  55                  60                  


His Leu Tyr Arg Asp Gly Lys Asp Gln Pro Phe Met Gln Met Pro Gln 
65                  70                  75                  80  


Tyr Gln Gly Arg Thr Lys Leu Val Lys Asp Ser Ile Ala Glu Gly Arg 
                85                  90                  95      


Ile Ser Leu Arg Leu Glu Asn Ile Thr Val Leu Asp Ala Gly Leu Tyr 
            100                 105                 110         


Gly Cys Arg Ile Ser Ser Gln Ser Tyr Tyr Gln Lys Ala Ile Trp Glu 
        115                 120                 125             


Leu Gln Val Ser Ala Leu Gly Ser Val Pro Leu Ile Ser Ile Thr Gly 
    130                 135                 140                 


Tyr Val Asp Arg Asp Ile Gln Leu Leu Cys Gln Ser Ser Gly Trp Phe 
145                 150                 155                 160 


Pro Arg Pro Thr Ala Lys Trp Lys Gly Pro Gln Gly Gln Asp Leu Ser 
                165                 170                 175     


Thr Asp Ser Arg Thr Asn Arg Asp Met His Gly Leu Phe Asp Val Glu 
            180                 185                 190         


Ile Ser Leu Thr Val Gln Glu Asn Ala Gly Ser Ile Ser Cys Ser Met 
        195                 200                 205             


Arg His Ala His Leu Ser Arg Glu Val Glu Ser Arg Val Gln Ile Gly 
    210                 215                 220                 


Asp Thr Phe Phe Glu Pro Ile Ser Trp His Leu Ala Thr Lys Val Leu 
225                 230                 235                 240 


Gly Ile Leu Cys Cys Gly Leu Phe Phe Gly Ile Val Gly Leu Lys Ile 
                245                 250                 255     


Phe Phe Ser Lys Phe Gln Cys Lys Arg Glu Arg Glu Ala Trp Ala Gly 
            260                 265                 270         


Ala Leu Phe Met Val Pro Ala Gly Thr Gly Ser Glu Met Leu Pro His 
        275                 280                 285             


Pro Ala Ala Ser Leu Leu Leu Val Leu Ala Ser Arg Gly Pro Gly Pro 
    290                 295                 300                 


Lys Lys Glu Asn Pro Gly Gly Thr Gly Leu Glu Lys Lys Ala Arg Thr 
305                 310                 315                 320 


Gly Arg Ile Glu Arg Arg Pro Glu Thr Arg Ser Gly Gly Asp Ser Gly 
                325                 330                 335     


Ser Arg Asp Gly Ser Pro Glu Ala Leu Arg Phe 
            340                 345         


<210>  8
<211>  2239
<212>  RNA
<213>  Homo sapiens

<400>  8
uagacauuua ugcagugguu caaagucuag agucccuaca cuucugguac augacagcug       60

ugucucgaug gaguagacuc ucagaacagc gcaguuugcc cuccgcucac gcagagccuc      120

uccguggcuu ccgcaccuug agcauuaggc caguucuccu cuucucucua auccauccgu      180

caccucuccu gucauccguu uccaugccgu gagguccauu cacagaacac auccauggcu      240

cucaugcuca guuugguucu gagucuccuc aagcugggau cagggcagug gcagguguuu      300

gggccagaca agccugucca ggccuuggug ggggaggacg cagcauucuc cuguuuccug      360

ucuccuaaga ccaaugcaga ggccauggaa gugcgguucu ucaggggcca guucucuagc      420

gugguccacc ucuacaggga cgggaaggac cagccauuua ugcagaugcc acaguaucaa      480

ggcaggacaa aacuggugaa ggauucuauu gcggaggggc gcaucucucu gaggcuggaa      540

aacauuacug uguuggaugc uggccucuau gggugcagga uuaguuccca gucuuacuac      600

cagaaggcca ucugggagcu acagguguca gcacugggcu caguuccucu cauuuccauc      660

acgggauaug uugauagaga cauccagcua cucugucagu ccucgggcug guucccccgg      720

cccacagcga aguggaaagg uccacaagga caggauuugu ccacagacuc caggacaaac      780

agagacaugc auggccuguu ugauguggag aucucucuga ccguccaaga gaacgccggg      840

agcauauccu guuccaugcg gcaugcucau cugagccgag agguggaauc caggguacag      900

auaggagaua ccuuuuucga gccuauaucg uggcaccugg cuaccaaagu acugggaaua      960

cucugcugug gccuauuuuu uggcauuguu ggacugaaga uuuucuucuc caaauuccag     1020

uguaagcgag agagagaagc augggccggu gccuuauuca ugguuccagc agggacagga     1080

ucagagaugc ucccacaucc agcugcuucu cuucuucuag uccuagccuc caggggccca     1140

ggcccaaaaa aggaaaaucc aggcggaacu ggacuggaga agaaagcacg gacaggcaga     1200

auugagagac gcccggaaac acgcagugga ggugacucug gauccagaga cggcucaccc     1260

gaagcucugc guuucugauc ugaaaacugu aacccauaga aaagcucccc aggaggugcc     1320

ucacucugag aagagauuua caaggaagag ugugguggcu ucucagaguu uccaagcagg     1380

gaaacauuac ugggaggugg acggaggaca caauaaaagg uggcgcgugg gagugugccg     1440

ggaugaugug gacaggagga aggaguacgu gacuuugucu cccgaucaug gguacugggu     1500

ccucagacug aauggagaac auuuguauuu cacauuaaau ccccguuuua ucagcgucuu     1560

ccccaggacc ccaccuacaa aaauaggggu cuuccuggac uaugagugug ggaccaucuc     1620

cuucuucaac auaaaugacc agucccuuau uuauacccug acaugucggu uugaaggcuu     1680

auugaggccc uacauugagu auccguccua uaaugagcaa aauggaacuc ccauagucau     1740

cugcccaguc acccaggaau cagagaaaga ggccucuugg caaagggccu cugcaauccc     1800

agagacaagc aacagugagu ccuccucaca ggcaaccacg cccuuccucc ccagggguga     1860

aauguaggau gaaucacauc ccacauucuu cuuuagggau auuaaggucu cucucccaga     1920

uccaaagucc cgcagcagcc ggccaaggug gcuuccagau gaagggggac uggccugucc     1980

acaugggagu caggugucau ggcugcccug agcugggagg gaagaaggcu gacauuacau     2040

uuaguuugcu cucacuccau cuggcuaagu gaucuugaaa uaccaccucu caggugaaga     2100

accgucagga auucccaucu cacaggcugu gguguagauu aaguagacaa ggaaugugaa     2160

uaaugcuuag aucuuauuga ugacagagug uauccuaaug guuuguucau uauauuacac     2220

uuucaguaaa aaaaaaaaa                                                  2239


<210>  9
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ser Asp Trp Gly Gln Gly Phe Pro Gln Asp Pro Pro Asp Thr Ser 
1               5                   10                  15      


Pro Ser Glu Gly Thr Asn Leu Asn Ala Pro Asn Ser Leu Gly Val Ser 
            20                  25                  30          


Ala Leu Cys Ala Ile Cys Gly Asp Arg Ala Thr Gly Lys His Tyr Gly 
        35                  40                  45              


Ala Ser Ser Cys Asp Gly Cys Lys Gly Phe Phe Arg Arg Ser Val Arg 
    50                  55                  60                  


Lys Asn His Met Tyr Ser Cys Arg Phe Ser Arg Gln Cys Val Val Asp 
65                  70                  75                  80  


Lys Asp Lys Arg Asn Gln Cys Arg Tyr Cys Arg Leu Lys Lys Cys Phe 
                85                  90                  95      


Arg Ala Gly Met Lys Lys Glu Ala Val Gln Asn Glu Arg Asp Arg Ile 
            100                 105                 110         


Ser Thr Arg Arg Ser Ser Tyr Glu Asp Ser Ser Leu Pro Ser Ile Asn 
        115                 120                 125             


Ala Leu Leu Gln Ala Glu Val Leu Ser Arg Gln Ile Thr Ser Pro Val 
    130                 135                 140                 


Ser Gly Ile Asn Gly Asp Ile Arg Ala Lys Lys Ile Ala Ser Ile Ala 
145                 150                 155                 160 


Asp Val Cys Glu Ser Met Lys Glu Gln Leu Leu Val Leu Val Glu Trp 
                165                 170                 175     


Ala Lys Tyr Ile Pro Ala Phe Cys Glu Leu Pro Leu Asp Asp Gln Val 
            180                 185                 190         


Ala Leu Leu Arg Ala His Ala Gly Glu His Leu Leu Leu Gly Ala Thr 
        195                 200                 205             


Lys Arg Ser Met Val Phe Lys Asp Val Leu Leu Leu Gly Asn Asp Tyr 
    210                 215                 220                 


Ile Val Pro Arg His Cys Pro Glu Leu Ala Glu Met Ser Arg Val Ser 
225                 230                 235                 240 


Ile Arg Ile Leu Asp Glu Leu Val Leu Pro Phe Gln Glu Leu Gln Ile 
                245                 250                 255     


Asp Asp Asn Glu Tyr Ala Tyr Leu Lys Ala Ile Ile Phe Phe Asp Pro 
            260                 265                 270         


Asp Ala Lys Gly Leu Ser Asp Pro Gly Lys Ile Lys Arg Leu Arg Ser 
        275                 280                 285             


Gln Val Gln Val Ser Leu Glu Asp Tyr Ile Asn Asp Arg Gln Tyr Asp 
    290                 295                 300                 


Ser Arg Gly Arg Phe Gly Glu Leu Leu Leu Leu Leu Pro Thr Leu Gln 
305                 310                 315                 320 


Ser Ile Thr Trp Gln Met Ile Glu Gln Ile Gln Phe Ile Lys Leu Phe 
                325                 330                 335     


Gly Met Ala Lys Ile Asp Asn Leu Leu Gln Glu Met Leu Leu Gly Gly 
            340                 345                 350         


Pro Cys Gln Ala Gln Glu Gly Arg Gly Trp Ser Gly Asp Ser Pro Gly 
        355                 360                 365             


Asp Arg Pro His Thr Val Ser Ser Pro Leu Ser Ser Leu Ala Ser Pro 
    370                 375                 380                 


Leu Cys Arg Phe Gly Gln Val Ala 
385                 390         


<210>  10
<211>  4737
<212>  RNA
<213>  Homo sapiens

<400>  10
gguuugaaag gaaggcagag agggcacugg gaggaggcag ugggagggcg gagggcgggg       60

gccuucgggg ugggcgccca ggguagggca gguggccgcg gcguggaggc agggagaaug      120

cgacucucca aaacccucgu cgacauggac auggccgacu acagugcugc acuggaccca      180

gccuacacca cccuggaauu ugagaaugug cagguguuga cgaugggcaa ugacacgucc      240

ccaucagaag gcaccaaccu caacgcgccc aacagccugg gugucagcgc ccugugugcc      300

aucugcgggg accgggccac gggcaaacac uacggugccu cgagcuguga cggcugcaag      360

ggcuucuucc ggaggagcgu gcggaagaac cacauguacu ccugcagauu uagccggcag      420

ugcguggugg acaaagacaa gaggaaccag ugccgcuacu gcaggcucaa gaaaugcuuc      480

cgggcuggca ugaagaagga agccguccag aaugagcggg accggaucag cacucgaagg      540

ucaagcuaug aggacagcag ccugcccucc aucaaugcgc uccugcaggc ggagguccug      600

ucccgacaga ucaccucccc cgucuccggg aucaacggcg acauucgggc gaagaagauu      660

gccagcaucg cagaugugug ugaguccaug aaggagcagc ugcugguucu cguugagugg      720

gccaaguaca ucccagcuuu cugcgagcuc ccccuggacg accagguggc ccugcucaga      780

gcccaugcug gcgagcaccu gcugcucgga gccaccaaga gauccauggu guucaaggac      840

gugcugcucc uaggcaauga cuacauuguc ccucggcacu gcccggagcu ggcggagaug      900

agccgggugu ccauacgcau ccuugacgag cuggugcugc ccuuccagga gcugcagauc      960

gaugacaaug aguaugccua ccucaaagcc aucaucuucu uugacccaga ugccaagggg     1020

cugagcgauc cagggaagau caagcggcug cguucccagg ugcaggugag cuuggaggac     1080

uacaucaacg accgccagua ugacucgcgu ggccgcuuug gagagcugcu gcugcugcug     1140

cccaccuugc agagcaucac cuggcagaug aucgagcaga uccaguucau caagcucuuc     1200

ggcauggcca agauugacaa ccuguugcag gagaugcugc ugggaggguc ccccagcgau     1260

gcaccccaug cccaccaccc ccugcacccu caccugaugc aggaacauau gggaaccaac     1320

gucaucguug ccaacacaau gcccacucac cucagcaacg gacagaugug ugaguggccc     1380

cgacccaggg gacaggcagc caccccugag accccacagc ccucaccgcc agguggcuca     1440

gggucugagc ccuauaagcu ccugccggga gccgucgcca caaucgucaa gccccucucu     1500

gccauccccc agccgaccau caccaagcag gaaguuaucu agcaagccgc uggggcuugg     1560

gggcuccacu ggcucccccc agcccccuaa gagagcaccu ggugaucacg uggucacggc     1620

aaaggaagac gugaugccag gaccaguccc agagcaggaa ugggaaggau gaagggcccg     1680

agaacauggc cuaagggcca caucccacug ccacccuuga cgcccugcuc uggauaacaa     1740

gacuuugacu uggggagacc ucuacugccu uggacaacuu uucucauguu gaagccacug     1800

ccuucaccuu caccuucauc cauguccaac ccccgacuuc aucccaaagg acagccgccu     1860

ggagaugacu ugaggccuua cuuaaaccca gcucccuucu ucccuagccu ggugcuucuc     1920

cucuccuagc cccugucaug guguccagac agagcccugu gaggcugggu ccaauugugg     1980

cacuuggggc accuugcucc uccuucugcu gcugccccca ccucugcugc cucccucugc     2040

ugucaccuug cucagccauc ccgucuucuc caacaccacc ucuccagagg ccaaggaggc     2100

cuuggaaacg auucccccag ucauucuggg aacauguugu aagcacugac ugggaccagg     2160

caccaggcag ggucuagaag gcugugguga gggaagacgc cuuucuccuc caacccaacc     2220

ucauccuccu ucuucaggga cuuggguggg uacuugggug aggaucccug aaggccuuca     2280

acccgagaaa acaaacccag guuggcgacu gcaacaggaa cuuggagugg agaggaaaag     2340

caucagaaag aggcagacca uccaccaggc cuuugagaaa ggguagaauu cuggcuggua     2400

gagcagguga gaugggacau uccaaagaac agccugagcc aaggccuagu gguaguaaga     2460

aucuagcaag aauugaggaa gaauggugug ggagagggau gaugaagaga gagagggccu     2520

gcuggagagc auagggucug gaacaccagg cugagguccu gaucagcuuc aaggaguaug     2580

cagggagcug ggcuuccaga aaaugaacac agcaguucug cagaggacgg gaggcuggaa     2640

gcugggaggu cagguggggu ggaugauaua augcggguga gaguaaugag gcuuggggcu     2700

ggagaggaca agauggguaa acccucacau cagagugaca uccaggagga auaagcuccc     2760

agggccuguc ucaagcucuu ccuuacuccc aggcacuguc uuaaggcauc ugacaugcau     2820

caucucauuu aauccucccu uccucccuau uaaccuagag auuguuuuug uuuuuuauuc     2880

uccuccuccc uccccgcccu cacccgcccc acucccuccu aaccuagaga uuguuacaga     2940

agcugaaauu gcguucuaag aggugaagug auuuuuuuuc ugaaacucac acaacuagga     3000

aguggcugag ucaggacuug aacccagguc ucccuggauc agaacaggag cucuuaacua     3060

caguggcuga auagcuucuc caaaggcucc cuguguucuc accgugauca aguugagggg     3120

cuuccggcuc ccuucuacag ccucagaaac cagacucguu cuucugggaa cccugcccac     3180

ucccaggacc aagauuggcc ugaggcugca cuaaaauuca cuuagggucg agcauccugu     3240

uugcugauaa auauuaagga gaauucauga cucuugacag cuuuucucuc uucacucccc     3300

aagucaaggg gagggguggc aggggucugu uuccuggaag ucaggcucau cuggccuguu     3360

ggcauggggg ugggacagug ugcacagugu gggggcaggg gagggcuaag caggccuggg     3420

uuugagggcu gcuccggaga ccgucacucc aggugcauuc uggaagcauu agaccccagg     3480

auggagcgac cagcauguca uccaugugga aucuuggugg cuuugaggac auucuggaaa     3540

augccacuga ccagugugaa caaaagggau guguuauggg gcuggaggug ugauuaggua     3600

ggagggaaac uguuggaccg acuccugccc ccugcucaac acugaccccu cugagugguu     3660

ggaggcagug ccccagugcc cagaaauccc accauuagug auuguuuuuu augagaaaga     3720

ggcguggaga aguauugggg caauguguca gggaggaauc accacauccc uacggcaguc     3780

ccagccaagc ccccaauccc agcggagacu gugcccugcu cagagcuccc aagccuuccc     3840

ccaccaccuc acucaagugc cccugaaauc ccugccagac ggcucagccu ggucugcggu     3900

aaggcaggga ggcuggaacc auuucugggc auugugguca uucccacugu guuccuccac     3960

cuccucccuc cagcguugcu cagaccucug ucuugggaga aagguugaga uaagaauguc     4020

ccauggagug ccgugggcaa caguggcccu ucaugggaac aaucuguugg agcagggggu     4080

caguucucug cugggaaucu accccuuucu ggaggagaaa cccauuccac cuuaauaacu     4140

uuauuguaau gugagaaaca caaaacaaag uuuacuuuuu ugacucuaag cugacaugau     4200

auuagaaaau cucucgcucu cuuuuuuuuu uuuuuuuuuu uuuuuggcua cuugaguugu     4260

gguccuaaaa cauaaaaucu gauggacaaa cagaggguug cuggggggac aagcgugggc     4320

acaauuuccc caccaagaca cccugaucuu caggcggguc ucaggagcuu cuaaaaaucc     4380

gcauggcucu ccugagagug gacagaggag aggagagggu cagaaaugaa cgcucuucua     4440

uuucuuguca uuaccaagcc aauuacuuuu gccaaauuuu ucugugaucu gcccugauua     4500

agaugaauug ugaaauuuac aucaagcaau uaucaaagcg ggcugggucc caucagaacg     4560

acccacaucu uucugugggu gugaauguca uuaggucuug cgcugacccc ugagccccca     4620

ucacugccgc cugauggggc aaagaaacaa aaaacauuuc uuacucuucu guguuuuaac     4680

aaaaguuuau aaaacaaaau aaauggcgca uauguuuucu aaaaaaaaaa aaaaaaa        4737


<210>  11
<211>  4371
<212>  RNA
<213>  Mus musculus

<400>  11
gggaccuggg aggaggcagg aggagggcgg ggacgggggg ggcuggggcu cagcccaggg       60

gcuugggugg cauccugggc cgggcaggac agggggcuaa ggcgugggua ggggagaaug      120

cgacucucua aaacccuugc cggcauggau auggccgacu acagcgcugc ccuggaccca      180

gccuacacca cccuggaguu ugaaaaugug cagguguuga ccaugggcaa ugacacgucc      240

ccaucugaag gugccaaccu caauucaucc aacagccugg gcgucagugc ccugugcgcc      300

aucuguggcg accgggccac cggcaaacac uacggagccu cgagcuguga cggcugcaag      360

ggguucuuca ggaggagcgu gaggaagaac cacauguacu ccugcagguu uagccgacaa      420

ugugugguag acaaagauaa gaggaaccag ugucguuacu gcaggcuuaa gaagugcuuc      480

cgggcuggca ugaagaagga agcuguccaa aaugagcggg accggaucag cacgcggagg      540

ucaagcuacg aggacagcag ccugcccucc aucaacgcgc uccugcaggc agagguucug      600

ucccagcaga ucaccucucc caucucuggg aucaauggcg acauucgggc aaagaagauu      660

gccaacauca cagacgugug ugagucuaug aaggagcagc ugcugguccu ggucgagugg      720

gccaaguaca ucccggccuu cugcgaacuc cuucuggaug accagguggc gcugcucagg      780

gcccacgccg gugagcaucu gcugcuugga gccaccaaga gguccauggu guuuaaggac      840

gugcugcucc uaggcaauga cuacaucguc ccucggcacu guccagagcu agcggagaug      900

agccgugugu ccauccgcau ccucgaugag cugguccugc ccuuccaaga gcugcagauu      960

gaugacaaug aauaugccug ccucaaagcc aucaucuucu uugauccaga ugccaagggg     1020

cugagugacc cgggcaagau caagcggcug cggucacagg ugcaagugag ccuggaggau     1080

uacaucaacg accggcagua cgacucucgg ggccgcuuug gagagcugcu gcugcuguug     1140

cccacgcugc agagcaucac cuggcagaug aucgaacaga uccaguucau caagcucuuc     1200

ggcauggcca agauugacaa ccugcugcag gagaugcuuc ucggaggguc ugccagugau     1260

gcaccccaca cccaccaccc ccugcacccu caccugaugc aagaacacau gggcaccaau     1320

gucauuguug cuaacacgau gcccucucac cucagcaaug gacagaugug ugaguggccc     1380

cgacccaggg ggcaggcagc cacucccgag acuccacagc caucaccacc aaguggcucg     1440

ggaucugaau ccuacaagcu ccugccagga gccaucacca ccaucgucaa gccucccucu     1500

gccauucccc agccaacgau caccaagcaa gaagccaucu agcaagcugc uggggggguc     1560

agggguucug cuggcucaua cccucagaag agcaccuggg aguaaccuag ucauggcaaa     1620

gaagauguga cacgagggac cagucccaga gcagcuacag aaagggugug aggccccaaa     1680

accgugugcu gaggggcgaa ugcgucgcca ccccugaccc cgcaucugga gggcggggcu     1740

uugcuugaga agaccccagg gaggacuguc uuccacugcc uggacuccuc ucaaguugaa     1800

gucaucgucu ucaucuuccu ccguaucuuc uucccucaac uucuucaccc cugaaggacg     1860

acugucugca gauguugcag gaccuuguuu uaaaaucaac ucccuucucu cccagcgggg     1920

ggccucuucc uuccuggugc uggucagggg gccuggaaac aaacuuucug aggcuggguc     1980

agcuugccuu auaguacucc ucuccugcua ugccaaccuc aggugaccug cuaccauccu     2040

cuauaccuuc cuccgccauc ugacuucucu aaagccaucu cucuggaggc ugaggaagcu     2100

gugguaacca uuuccccacu cauucugaga gccuucugua agcacugacc uggguaaggc     2160

agaggguagg agucaccauc ccuccucugc caauaucgcu acaacuccug ccuccagcac     2220

uaggcuauaa cuuuggagug auaaguccua uggcuuucua caguagagaa ccacccaagg     2280

gugucgauua uaacagaaug uggagagugg guggccguca uugggaaagc aucgagaaag     2340

aggcgagcuu ugcaucuguc ccuugacagg gaagguaggc uucuggcuag cagagcaggu     2400

gacacaaacc aguuuauugg agaacagccu ggacaaaggc ccauagguag guaaaauagu     2460

augggaggga ggcaaugaag aaaucaguuc ccauggaguu gugacagggu acacacuggg     2520

gaccauugaa ugacaaacug aggucagggg uagcugcagu guggggcugu cagaagauga     2580

auacagcauc ccgcagaggu aggauaugag gaggcuauac uggagcguag ggaugagaua     2640

aagggaugga uccgaguccu cccggggccu gccaagcuuu uccauacuuc cagaugaugu     2700

uauaaggcau uaaacagcca ccaucgcaua gaaccuuccc uguaacccag acauugucaa     2760

ggaagauaua cguagaggau cuuaacugac ucacaggaag cacuuguccc cccuggcacg     2820

gaauccagag gguuccucgu ccuuuaccag ugucaacccc agaggcuuuc ucucuccaga     2880

acuggccagc uagagaccgu ucuaaagucc acuggaaguc aagaaucucg uuuacugaua     2940

auaguaaagu ugauucauga ccccuguccu uuuuuuucua cugaucuacc caaguguagg     3000

ugagccgcag cagggaguga uuccuagaag acggaucagu cuagucuggc agucaaggcu     3060

caggaguuug ggagaggggc aggagaagga uaagaaagcc uggguuuuag gcuugccugg     3120

gaagcuacag ucaaggugca uucugggagc uacucauccc cagcaguuag cgcuccgccc     3180

cgguugacuc uugauggcuu ugcggagccc cugcaaagug ucacuaguca augggaacaa     3240

gaggaauguc cccuggucug gaagugugcu aaguggaagg aaugggcugu gagacuggau     3300

aguuauggug caucaaggcu gauccuucug auuggguggg gcgagcaucc caguguccaa     3360

aaauuccagc cuaaaugaca gguccucuga aaaagaggug cugaggagua auggggccag     3420

cugauuaaag aaaaagaacc cccacacaac aggacuguca ggacagauug aguuaacccc     3480

ucaagccaag ucccgggugu caggaacagu uguccaugcu cagagcccuc aagccauccu     3540

uggccacucu cacuccagug ccccccagag accccagcca gauggcucag acuguccugc     3600

augaaggcag gagagcugaa cucucucugg uccuugucuu ucccaaucuu ugucccucca     3660

uccccagugg caucaggaga ggaguaggua auguuggccu ucagugguag cagucuucug     3720

gggcaggggu cagccacugu cccaaucagu ccuuucugaa ggagaaaccc auuccacauu     3780

aacaaauuua uuacaguaca gggaacaugg aauaaaggaa aguuuacucu ucugauuaua     3840

agcugaggau gcuauguugc aguuuguuug cuuguuuuuu ucuucugagc uuuguuucua     3900

guacacgaua ugacgggacc aaguacaagc ugguggugga cagagcuggg ugccacaguu     3960

uuccaccaag agcagccucu uuucuucaug gaguucucag aaccuuucag gguucaggag     4020

gcuccccuga gaauagacag gagaggguca gaagcagacg uccuccuuuu cuugugauaa     4080

ccacgcuacu ugccuuugcu agagcucucu guggccaacc cugggaaaug cuaaucauga     4140

ccuucacacc aaacauucag aaguaggcug ugucccauca gaucaaucug caccuuccug     4200

ugguugugca aacaucacgg ggcccuaccc ugauccccaa ggccccacca ucacugccca     4260

aggggguaaa aaagagaaaa agcccucaaa aacaguucuu acuccugugu uuuagcaaaa     4320

auuuaucaaa caaaauaaau gguacuuaug uuuucuaaaa aaaaaaaaaa a              4371


<210>  12
<211>  474
<212>  PRT
<213>  Mus musculus

<400>  12

Met Arg Leu Ser Lys Thr Leu Ala Gly Met Asp Met Ala Asp Tyr Ser 
1               5                   10                  15      


Ala Ala Leu Asp Pro Ala Tyr Thr Thr Leu Glu Phe Glu Asn Val Gln 
            20                  25                  30          


Val Leu Thr Met Gly Asn Asp Thr Ser Pro Ser Glu Gly Ala Asn Leu 
        35                  40                  45              


Asn Ser Ser Asn Ser Leu Gly Val Ser Ala Leu Cys Ala Ile Cys Gly 
    50                  55                  60                  


Asp Arg Ala Thr Gly Lys His Tyr Gly Ala Ser Ser Cys Asp Gly Cys 
65                  70                  75                  80  


Lys Gly Phe Phe Arg Arg Ser Val Arg Lys Asn His Met Tyr Ser Cys 
                85                  90                  95      


Arg Phe Ser Arg Gln Cys Val Val Asp Lys Asp Lys Arg Asn Gln Cys 
            100                 105                 110         


Arg Tyr Cys Arg Leu Lys Lys Cys Phe Arg Ala Gly Met Lys Lys Glu 
        115                 120                 125             


Ala Val Gln Asn Glu Arg Asp Arg Ile Ser Thr Arg Arg Ser Ser Tyr 
    130                 135                 140                 


Glu Asp Ser Ser Leu Pro Ser Ile Asn Ala Leu Leu Gln Ala Glu Val 
145                 150                 155                 160 


Leu Ser Gln Gln Ile Thr Ser Pro Ile Ser Gly Ile Asn Gly Asp Ile 
                165                 170                 175     


Arg Ala Lys Lys Ile Ala Asn Ile Thr Asp Val Cys Glu Ser Met Lys 
            180                 185                 190         


Glu Gln Leu Leu Val Leu Val Glu Trp Ala Lys Tyr Ile Pro Ala Phe 
        195                 200                 205             


Cys Glu Leu Leu Leu Asp Asp Gln Val Ala Leu Leu Arg Ala His Ala 
    210                 215                 220                 


Gly Glu His Leu Leu Leu Gly Ala Thr Lys Arg Ser Met Val Phe Lys 
225                 230                 235                 240 


Asp Val Leu Leu Leu Gly Asn Asp Tyr Ile Val Pro Arg His Cys Pro 
                245                 250                 255     


Glu Leu Ala Glu Met Ser Arg Val Ser Ile Arg Ile Leu Asp Glu Leu 
            260                 265                 270         


Val Leu Pro Phe Gln Glu Leu Gln Ile Asp Asp Asn Glu Tyr Ala Cys 
        275                 280                 285             


Leu Lys Ala Ile Ile Phe Phe Asp Pro Asp Ala Lys Gly Leu Ser Asp 
    290                 295                 300                 


Pro Gly Lys Ile Lys Arg Leu Arg Ser Gln Val Gln Val Ser Leu Glu 
305                 310                 315                 320 


Asp Tyr Ile Asn Asp Arg Gln Tyr Asp Ser Arg Gly Arg Phe Gly Glu 
                325                 330                 335     


Leu Leu Leu Leu Leu Pro Thr Leu Gln Ser Ile Thr Trp Gln Met Ile 
            340                 345                 350         


Glu Gln Ile Gln Phe Ile Lys Leu Phe Gly Met Ala Lys Ile Asp Asn 
        355                 360                 365             


Leu Leu Gln Glu Met Leu Leu Gly Gly Ser Ala Ser Asp Ala Pro His 
    370                 375                 380                 


Thr His His Pro Leu His Pro His Leu Met Gln Glu His Met Gly Thr 
385                 390                 395                 400 


Asn Val Ile Val Ala Asn Thr Met Pro Ser His Leu Ser Asn Gly Gln 
                405                 410                 415     


Met Cys Glu Trp Pro Arg Pro Arg Gly Gln Ala Ala Thr Pro Glu Thr 
            420                 425                 430         


Pro Gln Pro Ser Pro Pro Ser Gly Ser Gly Ser Glu Ser Tyr Lys Leu 
        435                 440                 445             


Leu Pro Gly Ala Ile Thr Thr Ile Val Lys Pro Pro Ser Ala Ile Pro 
    450                 455                 460                 


Gln Pro Thr Ile Thr Lys Gln Glu Ala Ile 
465                 470                 


<210>  13
<211>  23
<212>  RNA
<213>  Mus musculus

<400>  13
ccagcuccaa gaucccccuu ggg                                               23


<210>  14
<211>  23
<212>  RNA
<213>  Mus musculus

<400>  14
uccauagcac cuuauccggu ugg                                               23


<210>  15
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  15
gaatatccat ggcttttgtg c                                                 21


<210>  16
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  16
gtcttctctg tctcatcccc                                                   20


<210>  17
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  17
ccattcacag aacacatcca tg                                                22


<210>  18
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  18
tatgggttac agttttcaga tcag                                              24


<210>  19
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  19
gtgggatgtg attcatccta c                                                 21


<210>  20
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  20
atgcagtggg ccctagcg                                                     18


<210>  21
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  21
atgctgttgg ctctagctct gcttc                                             25


<210>  22
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  22
atgctgtcac tgctccacac atc                                               23


<210>  23
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  23
ttatgatttc tctccattgc agcag                                             25


<210>  24
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  24
atgctgttct ccagcctgct g                                                 21


<210>  25
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  25
atgcagagga tctcctccct cat                                               23


<210>  26
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  26
atgattctta ctgtgggctt tagctttttg                                        30


<210>  27
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  27
ttacaagaaa aataacttgg cagtcaagag                                        30


<210>  28
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  28
agtatctcct gatatgcagc atg                                               23


<210>  29
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  29
ggaggaactc tcttcttctt ttcac                                             25


<210>  30
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  30
tggtatctct tgatatgcag catag                                             25


<210>  31
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  31
agagcatcag gctgacttat tgg                                               23


<210>  32
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  32
gccgccacca tggcgccccc gcag                                              24


<210>  33
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  33
ttatgcattg agttccctat gca                                               23


<210>  34
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  34
gaaggtgaag gtcggagtc                                                    19


<210>  35
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  35
gaagatggtg atgggatttc                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  36
tgaccaggag aaatcgaagg                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  37
caccgagcag gaccaatagt                                                   20


<210>  38
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  38
cattctcctc agagacccac acta                                              24


<210>  39
<211>  19
<212>  DNA
<213>  Mus musculus

<400>  39
gagaggcctg agggaagaa                                                    19


<210>  40
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  40
gcacctctct ggtgaaggag                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  41
accgtcttct ggacctttga                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  42
cagcttcttt gcagctcctt                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  43
cacgatggag gggaatacag                                                   20


<210>  44
<211>  18
<212>  DNA
<213>  Mus musculus

<400>  44
ctccaggcct tcccagac                                                     18


<210>  45
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  45
catggacttc cagcgagaac                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  46
ggtgaccagc taccagagga                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  47
ccacatactg aatggcctca                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  48
ggggagctgt gatgtgaagt                                                   20


<210>  49
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  49
ccaggaaata attctggctc a                                                 21


<210>  50
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  50
caaatgctgg accaaacaca a                                                 21


<210>  51
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  51
ccatccagcc attcagtctt g                                                 21


<210>  52
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  52
actggcttcc tcagagtcat                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  53
cagtagtgaa tggcccctga                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  54
gaccaacgct tccctacctc                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  55
gccttgggtc caacaagaca                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  56
ggttttctgt gaagggacca                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  57
ggtctgcaac tcagaggagg                                                   20


