                         SEQUENCE LISTING

<110>  National Research Council Canada
 
<120>  AXL-SPECIFIC ANTIBODIES AND USES THEREOF

<130>  PAT 86600W-90

<150>  US 62/557,870
<151>  2017-09-13

<160>  188   

<170>  PatentIn version 3.5

<210>  1
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR L1-B consensus


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = S or T

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = I or N

<400>  1

Lys Ser Ser Gln Ser Leu Leu Asn Xaa Arg Thr Arg Lys Xaa Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR L2-B consensus


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is E, H or Q

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is S or T

<400>  2

Trp Ala Ser Thr Arg Xaa Xaa 
1               5           


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR H1-B consensus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is F or Y

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is I, S, or T

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is S, N, or K

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is F or Y

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is G or W

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is i or M

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is N, S, or H

<400>  3

Gly Xaa Thr Phe Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10  


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR H2-B consensus


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is F, N, or Y

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is G, N, or D

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is S or T

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is A or T

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is N or D

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is S or R

<400>  4

Asn Ile Xaa Pro Xaa Ser Xaa Ser Xaa Xaa Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Xaa 
    


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR H3-B consensus


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is T or Y

<400>  5

Asp Xaa Tyr Gly Gly Ser Pro Asp Tyr 
1               5                   


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR L2-B consensus (2)


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is E or Q

<400>  6

Trp Ala Ser Thr Arg Xaa Ser 
1               5           


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR H1-B consensus (2)


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is F or Y

<400>  7

Gly Tyr Thr Phe Thr Ser Xaa Trp Ile Asn 
1               5                   10  


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR H2-B consensus (2)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is F or Y

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is G or D

<400>  8

Asn Ile Xaa Pro Xaa Ser Ser Ser Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  9
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-7H5 CDR L1-B

<400>  9

Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Ile Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-7H5 CDR L2-B

<400>  10

Trp Ala Ser Thr Arg Gln Ser 
1               5           


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-7H5/F107 & 8D12 CDR L3-B

<400>  11

Lys Gln Ser Tyr Asn Leu Trp Thr 
1               5               


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-7H5 CDR H1-B

<400>  12

Gly Tyr Thr Phe Thr Ser Tyr Trp Ile Asn 
1               5                   10  


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-7H5 CDR H2-B

<400>  13

Asn Ile Tyr Pro Asp Ser Ser Ser Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-7H5 CDR H3-B

<400>  14

Asp Thr Tyr Gly Gly Ser Pro Asp Tyr 
1               5                   


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-8D12 CDR L1-B

<400>  15

Lys Ser Ser Gln Ser Leu Leu Asn Thr Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-8D12 CDR L2-B

<400>  16

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-8D12 CDR H1-B

<400>  17

Gly Tyr Thr Phe Ile Ser Phe Trp Ile Asn 
1               5                   10  


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-8D12 CDR H2-B

<400>  18

Asn Ile Phe Pro Gly Ser Ser Ser Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-8D12 CDR H3-B

<400>  19

Asp Tyr Tyr Gly Gly Ser Pro Asp Tyr 
1               5                   


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-5E9 CDR L1-B

<400>  20

Arg Ala Ser Gln Asp Ile Asn Asn Tyr Leu Asn 
1               5                   10      


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-5E9 CDR L2-B

<400>  21

Tyr Ile Ser Arg Leu His Ser 
1               5           


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-5E9  CDR L3-B

<400>  22

Gln Gln Gly Asn Thr Leu Pro Phe Thr 
1               5                   


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-5E9 CDR H1-B

<400>  23

Lys Tyr Gly Met Asn 
1               5   


<210>  24
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-5E9 CDR H2-B

<400>  24

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-5E9 CDR H3-B

<400>  25

Gly Gly Tyr Tyr Ser Asn Pro Ile Tyr Pro Met Asp Tyr 
1               5                   10              


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-3C8 CDR L1-B

<400>  26

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-3C8 CDR L2-B

<400>  27

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-3C8 CDR L3-B

<400>  28

Gln Gln Tyr His Asn Tyr Pro Pro Thr 
1               5                   


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-3C8 CDR H1-B

<400>  29

Gly Tyr Thr Phe Thr Ser Tyr Trp Met His 
1               5                   10  


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-3C8 CDR H2-B

<400>  30

Asn Ile Asn Pro Asn Ser Thr Ser Ala Asp Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Arg 
    


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-3C8 CDR H3-B

<400>  31

Pro Leu Met Gly Pro Tyr Trp Tyr Phe Asp Val 
1               5                   10      


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-10G1 CDR L1-B

<400>  32

Lys Ala Ser Gln Asp Val Thr Thr Ala Val Ala 
1               5                   10      


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-10G1 CDR L2-B

<400>  33

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-10G1 CDR L3-B

<400>  34

Gln Gln His Phe Thr Thr Pro Leu Thr 
1               5                   


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-10G1 CDR H1-B

<400>  35

Asn Tyr Gly Met Ser 
1               5   


<210>  36
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-10G1 CDR H2-B

<400>  36

Ser Ile Ser Gly Gly Gly Gly Arg Thr Tyr Tyr Leu Asp Asn Val Lys 
1               5                   10                  15      


Gly 
    


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-10G1 CDR H3-B

<400>  37

Gly Ala Arg Ala Ser Tyr Phe Ala Met Asp Tyr 
1               5                   10      


<210>  38
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-7H5 VL

<400>  38

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Ile Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  39
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-7H5 VH

<400>  39

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Asp Ser Ser Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Thr Tyr Gly Gly Ser Pro Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  40
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-8D12 VL

<400>  40

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Thr 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  41
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-8D12 VH

<400>  41

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Gln Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Phe 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Phe Pro Gly Ser Ser Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Gly Ser Pro Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  42
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-3C8 VL

<400>  42

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His Asn Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  43
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-3C8 VH

<400>  43

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Gly Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Arg Val Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Ser Thr Ser Ala Asp Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Arg Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Thr Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Pro Leu Met Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  44
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-5E9 VL

<400>  44

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ile Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Leu 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  45
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-5E9 VH

<400>  45

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Lys Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Thr Thr Glu Asp Met Val Thr Tyr Phe Cys 
                85                  90                  95      


Ala Lys Gly Gly Tyr Tyr Ser Asn Pro Ile Tyr Pro Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  46
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-10G1 VL

<400>  46

Val Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Thr Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Val Gln Thr 
65                  70                  75                  80  


Glu Asp Leu Ala Phe Tyr Tyr Cys Gln Gln His Phe Thr Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  47
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-10G1 VH

<400>  47

Glu Val Asn Leu Val Glu Ser Gly Gly Gly Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Ser Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Gly Gly Gly Gly Arg Thr Tyr Tyr Leu Asp Asn Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Leu Phe Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Arg Ala Ser Tyr Phe Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Ser Ser Val Thr Val Ser Ser 
        115                 120 


<210>  48
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric F107-7H5 light chain

<400>  48

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Ile Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  49
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric F107-7H5 heavy chain

<400>  49

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Asp Ser Ser Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Thr Tyr Gly Gly Ser Pro Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445         


<210>  50
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric F107-8D12 light chain

<400>  50

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Thr 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  51
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric F107-8D12 heavy chain

<400>  51

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Gln Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Phe 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Phe Pro Gly Ser Ser Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Gly Ser Pro Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445         


<210>  52
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric F111-3C8 light chain

<400>  52

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His Asn Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  53
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric F111-3C8 heavy chain

<400>  53

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Gly Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Arg Val Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Ser Thr Ser Ala Asp Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Arg Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Thr Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Pro Leu Met Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  54
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric F111-5E9 light chain

<400>  54

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ile Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Leu 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  55
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric F111-5E9 heavy chain

<400>  55

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Lys Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Thr Thr Glu Asp Met Val Thr Tyr Phe Cys 
                85                  90                  95      


Ala Lys Gly Gly Tyr Tyr Ser Asn Pro Ile Tyr Pro Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  56
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric F107-10G1 light chain

<400>  56

Val Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Thr Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Val Gln Thr 
65                  70                  75                  80  


Glu Asp Leu Ala Phe Tyr Tyr Cys Gln Gln His Phe Thr Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  57
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric F107-10G1 heavy chain

<400>  57

Glu Val Asn Leu Val Glu Ser Gly Gly Gly Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Ser Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Gly Gly Gly Gly Arg Thr Tyr Tyr Leu Asp Asn Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Leu Phe Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Arg Ala Ser Tyr Phe Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Ser Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  58
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhAXL-ECD

<400>  58

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp Gly Ser Gly Gly Gly Ser Ser Thr Gly 
    450                 455                 460 


<210>  59
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain signal sequence

<400>  59

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly 
            20  


<210>  60
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain signal sequence

<400>  60

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala 
            


<210>  61
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F107-7H5 VL sequence

<400>  61
gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagat ctacttggct      120

tggtaccagc agaaaccagg tcagtctcct aaactgctga tctattgggc atccactagg      180

caatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctg      300

tggacgttcg gtggaggcac caagctggaa atcaaacgg                             339


<210>  62
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F107-7H5 VH sequence

<400>  62
caggtccaac tgcagcagcc tggggctgag cttgtgaagc ctggggcttc agtgaaactg       60

tcctgcaagg cttctggcta cactttcacc agctactgga taaactgggt gaagcagagg      120

cctggacaag gccttgagtg gattggaaat atttatcctg atagtagtag tactaactac      180

aatgagaagt tcaagagcaa ggccacactg actgtagaca agtcctccac cacagcctac      240

atacagttca gcagcctgac atctgaggac tctgcggtct attattgtac aagagatacc      300

tatggtggta gccctgacta ctggggccaa ggcaccactc tcacagtctc ctca            354


<210>  63
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F107-8D12 VL sequence

<400>  63
gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gagggtcact       60

atgagctgca aatccagtca gagtctgctc aacactagaa cccgaaagaa ctacttggct      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  64
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F107-8D12 VH sequence

<400>  64
caggtccaac tgcagcagcc tggggctgag cttgtgaagc ctggggcttc agtgcagctg       60

tcctgcaagg cttctggcta cactttcatc agcttctgga taaactgggt gaagcagagg      120

cctggacaag gccttgagtg gatgggaaat atttttcctg gtagtagtag tacgaactac      180

aatgagaagt tcaagagcaa ggccacactg actgtagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcggtct atttttgtgc aagagattac      300

tatggtggta gccctgacta ctggggccaa ggcaccactc tcacagtytc ctca            354


<210>  65
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F111-5E9 VL sequence

<400>  65
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattaac aattatttaa actggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctactac atatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcta      240

gaagatgttg ccacttactt ttgccaacag ggtaatacgc ttccattcac gttcggctcg      300

gggacaaagt tggaaataaa a                                                321


<210>  66
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F111-5E9 VH sequence

<400>  66
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca aaatatggaa tgaactgggt aaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat      180

gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat      240

ttgcagatca acaacctcac aactgaggac atggtcacat atttctgtgc aaaagggggg      300

tattatagta accctatcta tcctatggac tactggggtc aaggaacctc agtcaccgtc      360

tcctca                                                                 366


<210>  67
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F111-3C8 VL sequence

<400>  67
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atatcctgca gtgccagctc aagtgtaagt tacatgtatt ggtaccagca gaagccagga      120

tcctccccca aaccctggat ttatcgcaca tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtat cataattacc cacccacgtt cggagggggg      300

accaagctgg aaataaaacg g                                                321


<210>  68
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F111-3C8 VH sequence

<400>  68
caggtccaac tgcagcagcc tggggctgaa ctgggcaagc ctgggacatc agtgaagctg       60

tcctgcaagg cttctggcta caccttcacc agctattgga tgcactgggt gaagcgggtg      120

cctggacaag gccttgagtg gattggaaat attaatccta atagtactag tgctgactac      180

aatgagaagt tcaagaggaa ggccacattg actgtagaca aatcctccag cacagcctac      240

atgcagctca gcaccctgac atctgaggac tctgcggtct actactgtac aagaccccta      300

atgggtcctt actggtactt cgatgtctgg ggcacaggga ccacggtcac cgtctcctca      360


<210>  69
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F107-10G1 VL sequence

<400>  69
gtcattgtga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagt       60

atcacctgca aggccagtca ggatgtgact actgctgtag cctggtatca acaaaaacca      120

gggcaatctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat tattctctca ccatcagcaa tgtgcagact      240

gaagacctgg cattttatta ctgtcagcaa cattttacca ctcctctcac gttcggtgct      300

gggaccaagt tggagctgaa a                                                321


<210>  70
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F107-10G1 VH sequence

<400>  70
gaagtgaacc tggtggagtc tgggggaggc gtagtgaagc ctggagcgtc tctgaaactc       60

tcctgtgaag cctctggatt cactttcagt aactatggca tgtcttgggt tcgccagact      120

tcagacaaga ggctggagtg ggtcgcatcc attagtggtg gtggtggtag aacctactat      180

ctagacaatg taaagggccg attcatcatc tccagagaga atgccaagaa caccctgtac      240

ctgcaaatga gtagtctgaa gtctgaggac acggccttgt tttactgtgc aagaggagct      300

cgggcctctt actttgctat ggactactgg ggtcaaggaa gttcagtcac cgtctcctca      360


<210>  71
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (rh)AXL-ECD His8

<400>  71

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp Gly Ser Gly Gly Gly Ser Ser Thr Gly His His His His 
    450                 455                 460                 


His His His His Gly 
465                 


<210>  72
<211>  909
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AXL - full length His6

<400>  72

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val 
    450                 455                 460                 


Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg 
465                 470                 475                 480 


Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val 
                485                 490                 495     


Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr 
            500                 505                 510         


Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp 
        515                 520                 525             


Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu 
    530                 535                 540                 


Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser 
545                 550                 555                 560 


Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg 
                565                 570                 575     


Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe 
            580                 585                 590         


Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser 
        595                 600                 605             


Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys 
    610                 615                 620                 


His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln 
625                 630                 635                 640 


Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile 
                645                 650                 655     


Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp 
            660                 665                 670         


Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val 
        675                 680                 685             


Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg 
    690                 695                 700                 


Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser 
705                 710                 715                 720 


Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly 
                725                 730                 735     


Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly 
            740                 745                 750         


Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Arg Gly Asn Arg Leu 
        755                 760                 765             


Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg 
    770                 775                 780                 


Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg 
785                 790                 795                 800 


Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro 
                805                 810                 815     


Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu 
            820                 825                 830         


Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro 
        835                 840                 845             


Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly 
    850                 855                 860                 


Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala 
865                 870                 875                 880 


Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala Tyr Leu 
                885                 890                 895     


Glu Cys Gly Arg Tyr Ala Ser His His His His His His 
            900                 905                 


<210>  73
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F155-3C7 VH

<400>  73

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Phe 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Phe Pro Gly Ser Asn Ser Ser Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Tyr Tyr Gly Gly Ser Pro Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  74
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F155-3C7 VL

<400>  74

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Lys Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ala Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Ile Tyr Tyr Cys Lys His 
                85                  90                  95      


Ser Tyr Asn Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg 
            100                 105                 110         


<210>  75
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F149-4G4 VH

<400>  75

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Tyr Tyr 
            20                  25                  30          


Gly Ile Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Leu Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Arg Asp Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Thr Met Ser Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ala Leu Thr Val Ser Ser 
        115             


<210>  76
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F149-4G4 VL

<400>  76

Gln Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Glu Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr Ser Gly Asp Pro 
                85                  90                  95      


Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys 
            100                 105             


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-10G1 CDR H1-A

<400>  77

Gly Phe Thr Phe Ser Asn Tyr Gly 
1               5               


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-10G1 CDR H2-A

<400>  78

Ile Ser Gly Gly Gly Gly Arg Thr 
1               5               


<210>  79
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-10G1 CDR H3-A

<400>  79

Ala Arg Gly Ala Arg Ala Ser Tyr Phe Ala Met Asp Tyr 
1               5                   10              


<210>  80
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-10G1 CDR L1-A

<400>  80

Gln Asp Val Thr Thr Ala 
1               5       


<210>  81
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-10G1 CDR L2-A

<400>  81

Trp Ala Ser Thr 
1               


<210>  82
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-10G1 CDR L3-A

<400>  82

Gln Gln His Phe Thr Thr Pro Leu Thr 
1               5                   


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-5E9 CDR H1-A

<400>  83

Gly Tyr Thr Phe Thr Lys Tyr Gly 
1               5               


<210>  84
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-5E9 CDR H2-A

<400>  84

Ile Asn Thr Tyr Thr Gly Glu Pro 
1               5               


<210>  85
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-5E9 CDR H3-A

<400>  85

Ala Lys Gly Gly Tyr Tyr Ser Asn Pro Ile Tyr Pro Met Asp Tyr 
1               5                   10                  15  


<210>  86
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-5E9 CDR L1-A

<400>  86

Gln Asp Ile Asn Asn Tyr 
1               5       


<210>  87
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-5E9 CDR L2-A

<400>  87

Tyr Ile Ser Arg 
1               


<210>  88
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-5E9 CDR L3-A

<400>  88

Gln Gln Gly Asn Thr Leu Pro Phe Thr 
1               5                   


<210>  89
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-8D12 CDR H1-A

<400>  89

Gly Tyr Thr Phe Ile Ser Phe Trp 
1               5               


<210>  90
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-8D12 CDR H2-A

<400>  90

Ile Phe Pro Gly Ser Ser Ser Thr 
1               5               


<210>  91
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-8D12 CDR H3-A

<400>  91

Ala Arg Asp Tyr Tyr Gly Gly Ser Pro Asp Tyr 
1               5                   10      


<210>  92
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-8D12 CDR L1-A

<400>  92

Gln Ser Leu Leu Asn Thr Arg Thr Arg Lys Asn Tyr 
1               5                   10          


<210>  93
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-8D12 CDR L2-A

<400>  93

Trp Ala Ser Thr 
1               


<210>  94
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-8D12 CDR L3-A

<400>  94

Lys Gln Ser Tyr Asn Leu Trp Thr 
1               5               


<210>  95
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-7H5 CDR H1-A

<400>  95

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  96
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-7H5 CDR H2-A

<400>  96

Ile Tyr Pro Asp Ser Ser Ser Thr 
1               5               


<210>  97
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-7H5 CDR H3-A

<400>  97

Thr Arg Asp Thr Tyr Gly Gly Ser Pro Asp Tyr 
1               5                   10      


<210>  98
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-7H5 CDR L1-A

<400>  98

Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Ile Tyr 
1               5                   10          


<210>  99
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-7H5 CDR L2-A

<400>  99

Trp Ala Ser Thr 
1               


<210>  100
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F107-7H5 CDR L3-A

<400>  100

Lys Gln Ser Tyr Asn Leu Trp Thr 
1               5               


<210>  101
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F155-3C7 CDR H1-A

<400>  101

Gly Tyr Ile Phe Thr Asn Phe Trp 
1               5               


<210>  102
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F155-3C7 CDR H2-A

<400>  102

Ile Phe Pro Gly Ser Asn Ser Ser 
1               5               


<210>  103
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F155-3C7 CDR H3-A

<400>  103

Val Arg Asp Tyr Tyr Gly Gly Ser Pro Asp Tyr 
1               5                   10      


<210>  104
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F155-3C7 CDR L1-A

<400>  104

Gln Ser Leu Leu Asn Ser Lys Thr Arg Lys Asn Tyr 
1               5                   10          


<210>  105
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F155-3C7 CDR L2-A

<400>  105

Trp Ala Ser Thr 
1               


<210>  106
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F155-3C7 CDR L3-A

<400>  106

Lys His Ser Tyr Asn Leu Trp Thr 
1               5               


<210>  107
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-3C8 CDR H1-A

<400>  107

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  108
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-3C8 CDR H2-A

<400>  108

Ile Asn Pro Asn Ser Thr Ser Ala 
1               5               


<210>  109
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-3C8 CDR H3-A

<400>  109

Thr Arg Pro Leu Met Gly Pro Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  110
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-3C8 CDR L1-A

<400>  110

Ser Ser Val Ser Tyr 
1               5   


<210>  111
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-3C8 CDR L2-A

<400>  111

Arg Thr Ser Asn 
1               


<210>  112
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F111-3C8 CDR L3-A

<400>  112

Gln Gln Tyr His Asn Tyr Pro Pro Thr 
1               5                   


<210>  113
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F149-4G4 CDR H1-A

<400>  113

Gly Tyr Thr Phe Thr Tyr Tyr Gly 
1               5               


<210>  114
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F149-4G4 CDR H2-A

<400>  114

Ile Asn Thr Tyr Leu Gly Glu Pro 
1               5               


<210>  115
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F149-4G4 CDR H3-A

<400>  115

Thr Arg Gly Thr Met Ser Tyr Ser Phe Asp Tyr 
1               5                   10      


<210>  116
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F149-4G4 CDR L1-A

<400>  116

Ser Ser Ser Val Ser Ser Ser Tyr 
1               5               


<210>  117
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F149-4G4 CDR L2-A

<400>  117

Ser Thr Ser Lys 
1               


<210>  118
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F149-4G4 CDR L3-A

<400>  118

His Gln Tyr Ser Gly Asp Pro Leu Thr 
1               5                   


<210>  119
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb001

<400>  119

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Ala Ser Ile Ser Ser Phe Asp 
            20                  25                  30          


Ile Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Thr Leu Asp Ile Ala Asn Tyr Arg Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Arg Tyr His Cys Ala 
                85                  90                  95      


Ala Phe Gln Ser Asp Gln Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  120
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb002

<400>  120

Gln Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Thr Arg Thr Val Ser Ser Ala 
            20                  25                  30          


Val Met Ala Trp Phe Arg Gln Ala Pro Glu Lys Val Arg Asp Phe Val 
        35                  40                  45              


Gly Phe Ile Thr Asn Ser Gly Asn Ile Leu Tyr Asp Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Lys Trp Ser Phe Ser Ser Gly Tyr Gly Asp Leu Arg Arg Ala Ala 
            100                 105                 110         


Met Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  121
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb003

<400>  121

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Leu Asp Tyr Thr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Gly Asn Thr Asp Tyr Ala Glu Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Arg Ile Ser Arg Asp Asn Ser Lys Asn Thr Ile Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Arg Gly Gly Ala Arg Gly Glu Tyr Asp Tyr Trp Asp Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  122
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb004

<400>  122

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Phe Ser Arg Gly Ala Phe Asp Thr Tyr 
            20                  25                  30          


Glu Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Arg Asn Gly Asp Ser Val Val Tyr Ala Asp Ser Leu 
    50                  55                  60                  


Lys Ala Arg Phe Thr Ala Ser Arg Asn Asn Ala Val Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu His Met Asn Ile Leu Gln Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Trp Arg Pro Leu Arg Thr Ser Ser Gly Ala Asp Asp Tyr 
            100                 105                 110         


Ala Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  123
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb005

<400>  123

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Asn 
            20                  25                  30          


Thr Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ser Asp Ser Gly Ala Asn Arg Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Arg 
                85                  90                  95      


Ala Trp Gly Thr Gly Thr Ile Ser Thr Met Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  124
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb006

<400>  124

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Glu Ser Ile Phe Gly Phe Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Asn Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Ser Asn Ser Lys Arg Thr Met Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asn Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Ala Trp Gly Ile Ile Thr Ser Ala Thr Val Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  125
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb007

<400>  125

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Thr Arg Thr Val Ser Ser Ala 
            20                  25                  30          


Val Met Ala Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Asp Phe Val 
        35                  40                  45              


Gly Phe Ile Ser Asn Ser Gly Ser Val Tyr Tyr Asp Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ile Ile Trp Arg Thr Ser Asp Leu Thr Gly Arg Phe Asn Thr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  126
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb008

<400>  126

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Gly Met Ile Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Arg Arg Ser Thr Gly Gly Thr Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Asn Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ile Ile Trp Arg Thr Ser Asp Leu Thr Gly Arg Phe Asn Thr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  127
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb001 CDR1-A

<400>  127

Ala Ser Ile Ser Ser Phe Asp Ile 
1               5               


<210>  128
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb001 CDR2-A

<400>  128

Ile Thr Thr Leu Asp Ile Ala 
1               5           


<210>  129
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb001 CDR3-A

<400>  129

Ala Ala Phe Gln Ser Asp Gln Asn Tyr 
1               5                   


<210>  130
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb002 CDR1-A

<400>  130

Thr Arg Thr Val Ser Ser Ala Val 
1               5               


<210>  131
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb002 CDR2-A

<400>  131

Ile Thr Asn Ser Gly Asn Ile 
1               5           


<210>  132
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb002 CDR3-A

<400>  132

Ala Ala Lys Trp Ser Phe Ser Ser Gly Tyr Gly Asp Leu Arg Arg Ala 
1               5                   10                  15      


Ala Met Tyr Asp Tyr 
            20      


<210>  133
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb003 CDR1-A

<400>  133

Gly Val Thr Leu Asp Tyr Thr Ala 
1               5               


<210>  134
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb003 CDR2-A

<400>  134

Ile Thr Ser Gly Gly Asn Thr 
1               5           


<210>  135
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb003 CDR3-A

<400>  135

Ala Ala Arg Arg Gly Gly Ala Arg Gly Glu Tyr Asp Tyr 
1               5                   10              


<210>  136
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb004 CDR1-A

<400>  136

Arg Gly Ala Phe Asp Thr Tyr Glu 
1               5               


<210>  137
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb004 CDR2-A

<400>  137

Val Thr Arg Asn Gly Asp Ser Val 
1               5               


<210>  138
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb004 CDR3-A

<400>  138

Ala Ala Asn Trp Arg Pro Leu Arg Thr Ser Ser Gly Ala Asp Asp Tyr 
1               5                   10                  15      


Ala Asp 
        


<210>  139
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb005 CDR1-A

<400>  139

Gly Ser Ile Ser Ser Ile Asn Thr 
1               5               


<210>  140
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb005 CDR2-A

<400>  140

Ser Asp Ser Gly Ala Asn Arg 
1               5           


<210>  141
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb005 CDR3-A

<400>  141

Arg Ala Trp Gly Thr Gly Thr Ile Ser Thr Met Tyr 
1               5                   10          


<210>  142
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb006 CDR1-A

<400>  142

Glu Ser Ile Phe Gly Phe Asn Thr 
1               5               


<210>  143
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb006 CDR2-A

<400>  143

Ile Ser Asn Ser Lys Arg Thr 
1               5           


<210>  144
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb006 CDR3-A

<400>  144

Arg Ala Trp Gly Ile Ile Thr Ser Ala Thr Val Tyr 
1               5                   10          


<210>  145
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb007 CDR1-A

<400>  145

Thr Arg Thr Val Ser Ser Ala Val 
1               5               


<210>  146
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb007 CDR2-A

<400>  146

Ile Ser Asn Ser Gly Ser Val 
1               5           


<210>  147
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb007 CDR3-A

<400>  147

Ala Ile Ile Trp Arg Thr Ser Asp Leu Thr Gly Arg Phe Asn Thr 
1               5                   10                  15  


<210>  148
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb008 CDR1-A

<400>  148

Gly Ser Ser Gly Met Ile Asn Thr 
1               5               


<210>  149
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb008 CDR2-A

<400>  149

Arg Ser Thr Gly Gly Thr Thr 
1               5           


<210>  150
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb008 CDR3-A

<400>  150

Ala Ile Ile Trp Arg Thr Ser Asp Leu Thr Gly Arg Phe Asn Thr 
1               5                   10                  15  


<210>  151
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F155-3C7 CDR H1-B

<400>  151

Asn Phe Trp Ile Asn 
1               5   


<210>  152
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F155-3C7 CDR H2-B

<400>  152

Asn Ile Phe Pro Gly Ser Asn Ser Ser Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  153
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F155-3C7 CDR H3-B

<400>  153

Asp Tyr Tyr Gly Gly Ser Pro Asp Tyr 
1               5                   


<210>  154
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F155-3C7 CDR L1-B

<400>  154

Lys Ser Ser Gln Ser Leu Leu Asn Ser Lys Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  155
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F155-3C7 CDR L2-B

<400>  155

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  156
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F155-3C7 CDR L3-B

<400>  156

Lys His Ser Tyr Asn Leu Trp Thr 
1               5               


<210>  157
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F149-4G4 CDR H1-B

<400>  157

Tyr Tyr Gly Ile Asn 
1               5   


<210>  158
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F149-4G4 CDR H2-B

<400>  158

Trp Ile Asn Thr Tyr Leu Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  159
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F149-4G4 CDR H3-B

<400>  159

Gly Thr Met Ser Tyr Ser Phe Asp Tyr 
1               5                   


<210>  160
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F149-4G4 CDR L1-B

<400>  160

Arg Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  161
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F149-4G4 CDR L2-B

<400>  161

Ser Thr Ser Lys Leu Ala Ser 
1               5           


<210>  162
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F149-4G4 CDR L3-B

<400>  162

His Gln Tyr Ser Gly Asp Pro Leu Thr 
1               5                   


<210>  163
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb001 CDR1-B

<400>  163

Phe Asp Ile Met Gly 
1               5   


<210>  164
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb001 CDR2-B

<400>  164

Ala Ile Thr Thr Leu Asp Ile Ala Asn Tyr Arg Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  165
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb001 CDR3-B

<400>  165

Phe Gln Ser Asp Gln Asn Tyr 
1               5           


<210>  166
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb002 CDR1-B

<400>  166

Ser Ala Val Met Ala 
1               5   


<210>  167
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb002 CDR2-B

<400>  167

Phe Ile Thr Asn Ser Gly Asn Ile Leu Tyr Asp Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  168
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb002 CDR3-B

<400>  168

Lys Trp Ser Phe Ser Ser Gly Tyr Gly Asp Leu Arg Arg Ala Ala Met 
1               5                   10                  15      


Tyr Asp Tyr 
            


<210>  169
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb003 CDR1-B

<400>  169

Tyr Thr Ala Ile Gly 
1               5   


<210>  170
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb003 CDR2-B

<400>  170

Ala Ile Thr Ser Gly Gly Asn Thr Asp Tyr Ala Glu Ser Ala Lys Gly 
1               5                   10                  15      


<210>  171
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb003 CDR3-B

<400>  171

Arg Arg Gly Gly Ala Arg Gly Glu Tyr Asp Tyr 
1               5                   10      


<210>  172
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb004 CDR1-B

<400>  172

Thr Tyr Glu Ile Gly 
1               5   


<210>  173
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb004 CDR2-B

<400>  173

Ala Val Thr Arg Asn Gly Asp Ser Val Val Tyr Ala Asp Ser Leu Lys 
1               5                   10                  15      


Ala 
    


<210>  174
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb004 CDR3-B

<400>  174

Asn Trp Arg Pro Leu Arg Thr Ser Ser Gly Ala Asp Asp Tyr Ala Asp 
1               5                   10                  15      


<210>  175
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb005 CDR1-B

<400>  175

Ala Ser Asp Ser Gly Ala Asn Arg Asn Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  176
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb005 CDR2-B

<400>  176

Ala Ser Asp Ser Gly Ala Asn Arg Asn Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  177
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb005 CDR3-B

<400>  177

Trp Gly Thr Gly Thr Ile Ser Thr Met Tyr 
1               5                   10  


<210>  178
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb006 CDR1-B

<400>  178

Phe Asn Thr Met Gly 
1               5   


<210>  179
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb006 CDR2-B

<400>  179

Ser Ile Ser Asn Ser Lys Arg Thr Met Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  180
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb006 CDR3-B

<400>  180

Trp Gly Ile Ile Thr Ser Ala Thr Val Tyr 
1               5                   10  


<210>  181
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb007 CDR1-B

<400>  181

Ser Ala Val Met Ala 
1               5   


<210>  182
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb007 CDR2-B

<400>  182

Phe Ile Ser Asn Ser Gly Ser Val Tyr Tyr Asp Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  183
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb007 CDR3-B

<400>  183

Ile Trp Arg Thr Ser Asp Leu Thr Gly Arg Phe Asn Thr 
1               5                   10              


<210>  184
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb008 CDR1-B

<400>  184

Ile Asn Thr Met Gly 
1               5   


<210>  185
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb008 CDR2-B

<400>  185

Arg Arg Ser Thr Gly Gly Thr Thr Asn Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  186
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRC-sdAb008 CDR3-B

<400>  186

Ile Trp Arg Thr Ser Asp Leu Thr Gly Arg Phe Asn Thr 
1               5                   10              


<210>  187
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc peptide

<400>  187

Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
1               5                   10                  15      


Lys 
    


<210>  188
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A20.1 peptide

<400>  188

Glu Phe Val Ala Ala Gly Ser Ser Thr Gly Arg 
1               5                   10      


