                         SEQUENCE LISTING

<110>  Protagonist Therapeutics, Inc.
       Anandan, Sampath Kumar
       Zhang, Jie
       Bhandari, Ashok
       Bourne, Gregory Thomas
       Frederick, Brian Troy
       Mattheakis, Larry C.
       Liu, David

 
<120>  OPIOID AGONIST PEPTIDES AND USES THEREOF

<130>  PRTH-028/02WO 321085-2234

<150>  US 62/556,900
<151>  2017-09-11

<150>  US 62/663,660
<151>  2018-04-27

<160>  357   

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  D-form phenylalanine

<400>  1

Xaa Arg Phe Lys 
1               


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-form lysine

<400>  2

Xaa Arg Phe Lys 
1               


<210>  3
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  L-4,4'-Biphenylalanine

<400>  3

Xaa Arg Xaa Lys 
1               


<210>  4
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<400>  4

Xaa Arg His Lys 
1               


<210>  5
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  N-Methyl-Lysine

<400>  5

Xaa Arg Phe Xaa 
1               


<210>  6

<400>  6
000

<210>  7
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<400>  7

Xaa Arg Phe Lys 
1               


<210>  8
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-form N-Methyl-L-Alanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  alpha-aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  alpha-aminobutyric acid

<400>  8

Xaa Xaa Xaa Gly 
1               


<210>  9
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Sarcosine

<400>  9

Xaa Arg Phe Xaa 
1               


<210>  10
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-form N-Methyl-L-Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Sarcosine

<400>  10

Xaa Xaa Phe Xaa 
1               


<210>  11
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  N-Methyl-beta-Alanine

<400>  11

Xaa Arg Trp Xaa 
1               


<210>  12
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  homophenylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  N-Methyl-beta-Alanine

<400>  12

Xaa Arg Xaa Xaa 
1               


<210>  13
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  (1-naphthyl)-L-alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  N-Methyl-beta-Alanine

<400>  13

Xaa Arg Xaa Xaa 
1               


<210>  14
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-form N-Methyl-L-phenylalanine

<400>  14

Xaa Arg Phe Xaa 
1               


<210>  15
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  alpha-methyl-L-Phenylalanine

<400>  15

Xaa Arg Phe Xaa 
1               


<210>  16
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  4-Fluoro-L-Phenylalanine

<400>  16

Xaa Arg Phe Xaa 
1               


<210>  17
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  3,4-dimethoxy-L-phenylalanine

<400>  17

Xaa Arg Phe Xaa 
1               


<210>  18
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  homophenylalanine

<400>  18

Xaa Arg Phe Xaa 
1               


<210>  19
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  4-Fluoro-L-Phenylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Sarcosine

<400>  19

Xaa Arg Xaa Xaa 
1               


<210>  20
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  4-cyano-L-phenylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Sarcosine

<400>  20

Xaa Arg Xaa Xaa 
1               


<210>  21
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  L-1,2,3,4,-tetrahydro-isoquinoline-3-carboxylic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Sarcosine

<400>  21

Xaa Arg Xaa Xaa 
1               


<210>  22
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3,4 dichloro-L-phenylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Sarcosine

<400>  22

Xaa Arg Xaa Xaa 
1               


<210>  23
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  L-4,4'-Biphenylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Sarcosine

<400>  23

Xaa Arg Xaa Xaa 
1               


<210>  24
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  4-tert-butyl-L-phenylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Sarcosine

<400>  24

Xaa Arg Xaa Xaa 
1               


<210>  25
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3,4-dimethoxy-L-phenylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Sarcosine

<400>  25

Xaa Arg Xaa Xaa 
1               


<210>  26
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3,3,-diphenyl-L-alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Sarcosine

<400>  26

Xaa Arg Xaa Xaa 
1               


<210>  27
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  N-Octylglycine

<400>  27

Xaa Arg Phe Xaa 
1               


<210>  28
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  norleucine

<400>  28

Xaa Arg Phe Xaa 
1               


<210>  29
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<400>  29

Xaa Arg Phe Leu 
1               


<210>  30
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<400>  30

Xaa Arg Phe Val 
1               


<210>  31
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  norleucine

<400>  31

Xaa Arg Trp Xaa 
1               


<210>  32
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3,3,-diphenyl-L-alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Sarcosine

<400>  32

Xaa Arg Xaa Xaa 
1               


<210>  33
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  3,3,-diphenyl-L-alanine

<400>  33

Xaa Arg Gly Xaa 
1               


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<400>  34

Xaa Arg Gly Trp 
1               


<210>  35
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Sarcosine

<400>  35

Xaa Arg Xaa Trp 
1               


<210>  36
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  3,3,-diphenyl-L-alanine

<400>  36

Xaa Arg Phe Xaa 
1               


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  norleucine

<400>  37

Xaa Ala Gly Phe Xaa 
1               5   


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  4-Fluoro-L-Phenylalanine

<400>  38

Xaa Ala Gly Xaa Gly 
1               5   


<210>  39
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  4-cyano-L-phenylalanine

<400>  39

Xaa Ala Gly Xaa Gly 
1               5   


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-1,2,3,4,-tetrahydro-isoquinoline-3-carboxylic acid

<400>  40

Xaa Ala Gly Xaa Gly 
1               5   


<210>  41
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  3,4 dichloro-L-phenylalanine

<400>  41

Xaa Ala Gly Xaa Gly 
1               5   


<210>  42
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  42

Xaa Ala Gly Phe Xaa 
1               5   


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  43

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  44
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D form 1,2,3,4,-tetrahydro-isoquinoline-3-carboxylic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Sarcosine

<400>  44

Xaa Xaa Phe Xaa 
1               


<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D form 1,2,3,4,-tetrahydro-isoquinoline-3-carboxylic acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  45

Xaa Xaa Gly Phe Xaa 
1               5   


<210>  46
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  homophenylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Sarcosine

<400>  46

Xaa Ala Xaa Xaa 
1               


<210>  47
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  47

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  48
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  homophenylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  norleucine

<400>  48

Xaa Ala Xaa Xaa 
1               


<210>  49
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  norleucine

<400>  49

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  50
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  beta homo-L-Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  50

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  51
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-Methyl-L-Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  51

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  3-t-butyl-L-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  52

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  53
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-form tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  53

Tyr Ala Gly Xaa Xaa 
1               5   


<210>  54
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  homo-L-Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  54

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  55
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  3-chloro-L-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  55

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  56
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  meta-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  56

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  57
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  3-Fluoro-L-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  57

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Tyr(3-OH)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  58

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  59
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(4-NHCOCH3)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  59

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  60
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  4-Carbamoyl-L-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  60

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  61
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  61

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  62
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  62

Tyr Ala Gly Xaa Xaa 
1               5   


<210>  63
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  5-hydroxy-L-tryptophan

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  63

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Sarcosine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  64

Xaa Ala Xaa Xaa Xaa 
1               5   


<210>  65
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  THP

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  65

Xaa Ala Xaa Xaa Xaa 
1               5   


<210>  66
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  66

Xaa Ala Ala Xaa Xaa 
1               5   


<210>  67
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  67

Xaa Ala Leu Xaa Xaa 
1               5   


<210>  68
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  68

Xaa Ala Ile Xaa Xaa 
1               5   


<210>  69
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  69

Xaa Ala Val Xaa Xaa 
1               5   


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  70

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  4-(2-aminoethoxy)-L-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  71

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  72
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  alpha-aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  72

Xaa Ala Xaa Xaa Xaa 
1               5   


<210>  73
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  beta-alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  73

Xaa Ala Xaa Xaa Xaa 
1               5   


<210>  74
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  74

Xaa Gly Gly Xaa Xaa 
1               5   


<210>  75
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  alpha-aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  75

Xaa Xaa Gly Xaa Xaa 
1               5   


<210>  76
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  76

Xaa Thr Gly Xaa Xaa 
1               5   


<210>  77
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form aspartic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  77

Xaa Asp Gly Xaa Xaa 
1               5   


<210>  78
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  N-Methyl-L-Arginine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  78

Xaa Xaa Gly Xaa Xaa 
1               5   


<210>  79
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  79

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  80
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  80

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  81
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  81

Xaa Gly Gly Xaa Xaa 
1               5   


<210>  82
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  82

Xaa Thr Gly Xaa Xaa 
1               5   


<210>  83
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form aspartic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  83

Xaa Asp Gly Xaa Xaa 
1               5   


<210>  84
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form tyrosine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  84

Xaa Tyr Gly Xaa Xaa 
1               5   


<210>  85
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form tyrosine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  85

Xaa Asp Gly Xaa Xaa 
1               5   


<210>  86
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  86

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  87
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  87

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  88
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  88

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  89
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  4-Carboxy-L-Phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  89

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  90
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  alpha-aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  90

Xaa Xaa Gly Xaa Xaa 
1               5   


<210>  91
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  N-Methyl-L-Arginine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  91

Xaa Xaa Gly Xaa Xaa 
1               5   


<210>  92
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  92

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  93
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Alanine

<400>  93

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  94
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<400>  94

Xaa Ala Gly Xaa Gly 
1               5   


<210>  95
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Isoleucine

<400>  95

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  96
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Valine

<400>  96

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  97
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-Norvaline

<400>  97

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  98
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-cyclohxyl-alanine

<400>  98

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  99
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-Phenylglycine

<400>  99

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  100
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-Phenylalanine

<400>  100

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  101
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-Norleucine

<400>  101

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  102
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-tyrosine

<400>  102

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  103
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  1,2,3,4,-tetrahydro-isoquinoline-3-carboxylic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  103

Xaa Xaa Gly Xaa Xaa 
1               5   


<210>  104
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  1,2,3,4,-tetrahydro-isoquinoline-3-carboxylic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  104

Xaa Xaa Gly Xaa Xaa 
1               5   


<210>  105
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  4-Tetrazole-Phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  105

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  106
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-tryptophan

<400>  106

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  107
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  1,2,3,4,-tetrahydro-isoquinoline-3-carboxylic acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  107

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  108
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  1,2,3,4,-tetrahydro-isoquinoline-3-carboxylic acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  108

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  109
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-chloro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  109

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  110
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-iodo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  110

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  111
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Alanine

<400>  111

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  112
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<400>  112

Xaa Ala Gly Xaa Gly 
1               5   


<210>  113
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-Isoleucine

<400>  113

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  114
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  2-Nathyl Alanine

<400>  114

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  115
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N(Octyl)Glycine

<400>  115

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  116
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N(iospentyl)Glycine

<400>  116

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  117
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N(3-isopropyloxypropyl)Glycine

<400>  117

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  118
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N(benzyl)Glycine

<400>  118

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  119
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N(cyclohexylmethyl)Glycine

<400>  119

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  120
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N(3-propanoic acid)Glycine

<400>  120

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  121
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N(phenethyl)Glycine

<400>  121

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  122
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N(trifluoroethyl)Glycine

<400>  122

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  123
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N(cyclohexyl)Glycine

<400>  123

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  124
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N(amyl)Glycine

<400>  124

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  125
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N(hexadecyl)Glycine

<400>  125

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  126
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(2-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  126

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  127
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  127

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  128
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  128

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  129
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(2-fluoro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  129

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  130
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-fluoro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  130

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  131
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-fluoro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  131

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  132
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(2-bromo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  132

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  133
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-bromo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  133

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  134
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-bromo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  134

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  135
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-nitro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  135

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  136
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-iodo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  136

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  137
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-chloro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  137

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  138
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homotryrosine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  138

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  139
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homotryptophane

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  139

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  140
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(2-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  140

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  141
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  141

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  142
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  142

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  143
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(2-fluoro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  143

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  144
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-fluoro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  144

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  145
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-fluoro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  145

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  146
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(2-bromo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  146

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  147
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-bromo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  147

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  148
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-bromo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  148

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  149
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-nitro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  149

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  150
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-iodo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  150

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  151
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-chloro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  151

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  152
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homotryrosine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  152

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  153
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homotryptophane

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  153

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  154
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-form N-Methyl-Phenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Norleucine

<400>  154

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  155
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  155

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  156
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-cyclohxyl-alanine

<400>  156

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  157
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-Phenylglycine

<400>  157

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  158
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-Phenylalanine

<400>  158

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  159
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-Norleucine

<400>  159

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  160
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-tyrosine

<400>  160

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  161
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-Valine

<400>  161

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  162
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-Norvaline

<400>  162

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  163
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(2-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-Norleucine

<400>  163

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  164
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-Norleucine

<400>  164

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  165
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-Norleucine

<400>  165

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  166
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-fluoro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-Norleucine

<400>  166

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  167
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-chloro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-Norleucine

<400>  167

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  168
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homotryrosine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-Norleucine

<400>  168

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  169
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form aspartic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Leucine

<400>  169

Xaa Asp Gly Xaa Xaa 
1               5   


<210>  170
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form aspartic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Alanine

<400>  170

Xaa Asp Gly Xaa Xaa 
1               5   


<210>  171
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form aspartic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Tryptophan

<400>  171

Xaa Asp Gly Xaa Xaa 
1               5   


<210>  172
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form aspartic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Isoleucine

<400>  172

Xaa Asp Gly Xaa Xaa 
1               5   


<210>  173
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form aspartic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Valine

<400>  173

Xaa Asp Gly Xaa Xaa 
1               5   


<210>  174
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form aspartic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Norvaline

<400>  174

Xaa Asp Gly Xaa Xaa 
1               5   


<210>  175
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form aspartic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-cyclohexyl alanine

<400>  175

Xaa Asp Gly Xaa Xaa 
1               5   


<210>  176
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form aspartic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Phenylglycine

<400>  176

Xaa Asp Gly Xaa Xaa 
1               5   


<210>  177
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form aspartic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Phenylalanine

<400>  177

Xaa Asp Gly Xaa Xaa 
1               5   


<210>  178
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form aspartic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Norleucine

<400>  178

Xaa Asp Gly Xaa Xaa 
1               5   


<210>  179
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form aspartic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<400>  179

Xaa Asp Gly Xaa Gly 
1               5   


<210>  180
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form aspartic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Tyrosine

<400>  180

Xaa Asp Gly Xaa Xaa 
1               5   


<210>  181
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(2-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-Norleucine

<400>  181

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  182
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Isoleucine

<400>  182

Xaa Thr Gly Xaa Xaa 
1               5   


<210>  183
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Alanine

<400>  183

Xaa Thr Gly Xaa Xaa 
1               5   


<210>  184
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-Norvaline

<400>  184

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  185
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Glutamin Acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Alanine

<400>  185

Xaa Glu Gly Xaa Xaa 
1               5   


<210>  186
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Glutamin Acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-Isoleucine

<400>  186

Xaa Glu Gly Xaa Xaa 
1               5   


<210>  187
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Glutamin Acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  187

Xaa Glu Gly Xaa Xaa 
1               5   


<210>  188
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(2-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  188

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  189
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  189

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  190
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  190

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  191
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(2-fluoro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  191

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  192
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-fluoro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  192

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  193
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-fluoro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  193

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  194
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(2-bromo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  194

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  195
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-bromo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  195

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  196
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-bromo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  196

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  197
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-nitro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  197

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  198
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-iodo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  198

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  199
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-chloro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  199

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  200
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homotryrosine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  200

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  201
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homotryptophane

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  201

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  202
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(2-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  202

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  203
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  203

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  204
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  204

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  205
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(2-fluoro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  205

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  206
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-fluoro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  206

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  207
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-fluoro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  207

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  208
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(2-bromo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  208

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  209
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-bromo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  209

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  210
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-bromo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  210

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  211
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-nitro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  211

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  212
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-iodo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  212

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  213
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-chloro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  213

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  214
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homotryrosine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  214

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  215
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homotryptophane

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  215

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  216
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  216

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  217
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Alanine

<400>  217

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  218
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Isoleucine

<400>  218

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  219
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Valine

<400>  219

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  220
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Norvaline

<400>  220

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  221
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Cyclohexyl-alanine

<400>  221

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  222
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Phenylglycine

<400>  222

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  223
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Phenylalanine

<400>  223

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  224
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Norleucine

<400>  224

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  225
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Tyrosine

<400>  225

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  226
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Tryptophan

<400>  226

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  227
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Alanine

<400>  227

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  228
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<400>  228

Xaa Ala Gly Xaa Gly 
1               5   


<210>  229
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Isoleucine

<400>  229

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  230
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-form N-Methyl-Phenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Norleucine

<400>  230

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  231
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  231

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  232
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Cyclohexyl-alanine

<400>  232

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  233
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Phenylglycine

<400>  233

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  234
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Phenylalanine

<400>  234

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  235
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Norleucine

<400>  235

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  236
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Tyrosine

<400>  236

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  237
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Valine

<400>  237

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  238
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Norvaline

<400>  238

Xaa Thr Gly Xaa Xaa 
1               5   


<210>  239
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(2-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  239

Xaa Thr Gly Xaa Xaa 
1               5   


<210>  240
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  240

Xaa Thr Gly Xaa Xaa 
1               5   


<210>  241
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  241

Xaa Thr Gly Xaa Xaa 
1               5   


<210>  242
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(2-fluoro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  242

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  243
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-fluoro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  243

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  244
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-fluoro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  244

Xaa Thr Gly Xaa Xaa 
1               5   


<210>  245
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(2-bromo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  245

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  246
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-bromo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  246

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  247
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-bromo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  247

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  248
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-nitro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  248

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  249
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-iodo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  249

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  250
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-chloro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  250

Xaa Thr Gly Xaa Xaa 
1               5   


<210>  251
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homotryrosine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  251

Xaa Thr Gly Xaa Xaa 
1               5   


<210>  252
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homotryptophane

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  252

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  253
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(2-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  253

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  254
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  254

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  255
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  255

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  256
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(2-fluoro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  256

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  257
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-fluoro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  257

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  258
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-fluoro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  258

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  259
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(2-bromo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  259

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  260
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-bromo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  260

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  261
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-bromo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  261

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  262
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-nitro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  262

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  263
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-iodo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  263

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  264
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-chloro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  264

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  265
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homotryrosine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  265

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  266
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homotryptophane

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-L-Leucine

<400>  266

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  267
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  267

Xaa Ala Gly Xaa Xaa Lys 
1               5       


<210>  268
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-Alanine

<400>  268

Xaa Ala Gly Xaa Xaa Lys 
1               5       


<210>  269
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-Isoleucine

<400>  269

Xaa Ala Gly Xaa Xaa Lys 
1               5       


<210>  270
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  D-form Lysine

<400>  270

Xaa Ala Gly Xaa Xaa Lys 
1               5       


<210>  271
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Diglycolic acid

<400>  271

Xaa Ala Gly Xaa Xaa Xaa 
1               5       


<210>  272
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  272

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  273
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form Alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  273

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  274
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  N-methyl-phenylalanine

<400>  274

Xaa Arg Xaa Lys 
1               


<210>  275
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  beta-homophenylalanine

<400>  275

Xaa Arg Xaa Lys 
1               


<210>  276
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<400>  276

Xaa Arg Tyr Lys 
1               


<210>  277
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  (S)-3-Amino-4-(4-methyl-phenyl)-butyric acid

<400>  277

Xaa Arg Xaa Lys 
1               


<210>  278
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  4-Fluoro-L-Phenylalanine

<400>  278

Xaa Arg Xaa Lys 
1               


<210>  279
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<400>  279

Xaa Arg Trp Lys 
1               


<210>  280
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  (1-naphthyl)-L-alanine

<400>  280

Xaa Arg Xaa Lys 
1               


<210>  281
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  (2-naphthyl)-L-alanine

<400>  281

Xaa Arg Xaa Lys 
1               


<210>  282
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<400>  282

Tyr Arg Phe Lys 
1               


<210>  283
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  N-methyl-beta alanine

<400>  283

Tyr Arg Phe Xaa 
1               


<210>  284
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  D-form phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-form lysine

<400>  284

Xaa Arg Phe Lys 
1               


<210>  285
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  N-methyl beta alanine

<400>  285

Xaa Arg Phe Xaa 
1               


<210>  286
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-form tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  D-form phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-form lysine

<400>  286

Tyr Arg Phe Lys 
1               


<210>  287
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-form lysine

<400>  287

Tyr Arg Phe Lys 
1               


<210>  288
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  D-form arginine

<400>  288

Lys Tyr Arg Phe Lys 
1               5   


<210>  289
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-form tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<400>  289

Tyr Arg Phe Lys 
1               


<210>  290
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1-naphthyl)-L-alanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-Methyl-beta-Alanine

<400>  290

Lys Xaa Arg Xaa Xaa 
1               5   


<210>  291
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-form arginine

<400>  291

Tyr Arg Phe Arg 
1               


<210>  292
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  N-methyl arginine

<400>  292

Tyr Arg Phe Xaa 
1               


<210>  293
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-form arginine

<400>  293

Tyr Arg Tyr Arg 
1               


<210>  294
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  D-form tyrosine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-form arginine

<400>  294

Tyr Arg Tyr Arg 
1               


<210>  295
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  N-methyl-arginine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  N-methyl-lysine

<400>  295

Tyr Xaa Phe Xaa 
1               


<210>  296
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  N-methyl-arginine

<400>  296

Tyr Xaa Phe Lys 
1               


<210>  297
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-form norvaline

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  ornithine

<400>  297

Tyr Xaa Phe Xaa 
1               


<210>  298
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-form norleucine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  ornithine

<400>  298

Tyr Xaa Phe Xaa 
1               


<210>  299
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-form ornithine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  ornithine

<400>  299

Tyr Xaa Phe Xaa 
1               


<210>  300
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  homo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  beta-homophenylalanine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-form lysine

<400>  300

Xaa Arg Xaa Lys 
1               


<210>  301
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  homo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<400>  301

Xaa Arg Phe Lys 
1               


<210>  302
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  homo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  N-methyl-lysine

<400>  302

Xaa Arg Phe Xaa 
1               


<210>  303
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-methyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  N-methyl-lysine

<400>  303

Xaa Arg Phe Xaa 
1               


<210>  304
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-methyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-form lysine

<400>  304

Xaa Arg Phe Xaa 
1               


<210>  305
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form arginine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  N-methyl phenylalanine

<400>  305

Xaa Arg Phe Xaa 
1               


<210>  306
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  sarcosine

<400>  306

Xaa Ala Phe Xaa 
1               


<210>  307
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Sarcosine

<400>  307

Xaa Pro Phe Xaa 
1               


<210>  308
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form proline

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Sarcosine

<400>  308

Xaa Pro Phe Xaa 
1               


<210>  309
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  1,2,3,4,-tetrahydro-isoquinoline-3-carboxylic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Sarcosine

<400>  309

Xaa Xaa Phe Xaa 
1               


<210>  310
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form proline

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  310

Xaa Pro Gly Phe Xaa 
1               5   


<210>  311
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  1,2,3,4,-tetrahydro-isoquinoline-3-carboxylic acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  311

Xaa Xaa Gly Phe Xaa 
1               5   


<210>  312
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Sarcosine

<400>  312

Xaa Ala Xaa Xaa 
1               


<210>  313
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  1,2,3,4,-tetrahydro-isoquinoline-3-carboxylic acid

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Sarcosine

<400>  313

Xaa Xaa Xaa Xaa 
1               


<210>  314
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2,6-Dimethyl Tyrosine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  1,2,3,4,-tetrahydro-isoquinoline-3-carboxylic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  314

Xaa Xaa Gly Xaa Xaa 
1               5   


<210>  315
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-iodo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-Norleucine

<400>  315

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  316
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homotryptophan

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-Norleucine

<400>  316

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  317
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-form N-methyl-phenylalanine

<400>  317

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  318
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-form N-methyl-phenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-Norleucine

<400>  318

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  319
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(2-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-norleucine

<400>  319

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  320
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-norleucine

<400>  320

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  321
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-methyl-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-norleucine

<400>  321

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  322
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(2-fluoro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-norleucine

<400>  322

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  323
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-fluoro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-norleucine

<400>  323

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  324
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-fluoro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-norleucine

<400>  324

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  325
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(2-bromo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-norleucine

<400>  325

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  326
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(3-chloro-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-norleucine

<400>  326

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  327
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (S)-3-Amino-4-(4-iodo-phenyl)-butyric acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-norleucine

<400>  327

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  328
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homotyrosine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-norleucine

<400>  328

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  329
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homotryptophan

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-L-norleucine

<400>  329

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  330
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form glutamic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Sarcosine

<400>  330

Xaa Glu Gly Xaa Xaa 
1               5   


<210>  331
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form aspartic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-alanine

<400>  331

Xaa Asp Gly Xaa Xaa 
1               5   


<210>  332
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-alanine

<400>  332

Xaa Thr Gly Xaa Xaa 
1               5   


<210>  333
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form glutamic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-alanine

<400>  333

Xaa Glu Gly Xaa Xaa 
1               5   


<210>  334
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form aspartic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-isoleucine

<400>  334

Xaa Asp Gly Xaa Xaa 
1               5   


<210>  335
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-isoleucine

<400>  335

Xaa Thr Gly Xaa Xaa 
1               5   


<210>  336
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form glutamic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  N-methyl-isoleucine

<400>  336

Xaa Glu Gly Xaa Xaa 
1               5   


<210>  337
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  sarcosine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-form lysine

<400>  337

Gly Xaa Xaa Lys 
1               


<210>  338
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized opioid agonist peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  sarcosine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  D-form lysine

<400>  338

Ala Gly Xaa Xaa Lys 
1               5   


<210>  339
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Opioid agonist peptide formula


<220>
<221>  MOD_RES
<222>  (1)..(3)
<223>  Any amino acid or absent

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Tyr, D-form Tyr, a Tyr analog, Tic, a Tic analog, or a Phe analog

<220>
<221>  MOD_RES
<222>  (5)..(7)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (8)..(11)
<223>  Any amino acid or absent

<400>  339

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  340
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Opioid agonist peptide formula


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MOD_RES
<222>  (2)..(3)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Substituted or unsubstituted Phe, substituted or unsubstituted 
       b-homoPhe, or any N-methylamino acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Any amino acid, or any N-methylamino acid or absent

<400>  340

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  341
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Opioid agonist peptide formula


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(4-COX)

<220>
<221>  MOD_RES
<222>  (2)..(3)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Substituted or unsubstituted Phe, substituted or unsubstituted 
       b-homoPhe, or any N-methylamino acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Any amino acid, or any N-methylamino acid or absent

<400>  341

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  342
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Opioid agonist peptide formula


<220>
<221>  MOD_RES
<222>  (2)..(3)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Substituted or unsubstituted Phe, substituted or unsubstituted 
       b-homoPhe, or any N-methylamino acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Any amino acid, or any N-methylamino acid or absent

<400>  342

Tyr Xaa Xaa Xaa Xaa 
1               5   


<210>  343
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Opioid agonist peptide formula


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MOD_RES
<222>  (2)..(3)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Any amino acid, or any N-methylamino acid or absent

<400>  343

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  344
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Opioid agonist peptide formula


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(4-COX)

<220>
<221>  MOD_RES
<222>  (2)..(3)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Any amino acid, or any N-methylamino acid or absent

<400>  344

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  345
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Opioid agonist peptide formula


<220>
<221>  MOD_RES
<222>  (2)..(3)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Any amino acid, or any N-methylamino acid or absent

<400>  345

Tyr Xaa Xaa Xaa Xaa 
1               5   


<210>  346
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Opioid agonist peptide formula


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Any amino acid, or any N-methylamino acid or absent

<400>  346

Xaa Xaa Gly Xaa Xaa 
1               5   


<210>  347
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Opioid agonist peptide formula


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(4-COX)

<220>
<221>  MOD_RES
<222>  (2)..(3)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Any amino acid, or any N-methylamino acid or absent

<400>  347

Xaa Xaa Gly Xaa Xaa 
1               5   


<210>  348
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Opioid agonist peptide formula


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Any amino acid, or any N-methylamino acid or absent

<400>  348

Tyr Xaa Gly Xaa Xaa 
1               5   


<210>  349
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Opioid agonist peptide formula


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Any amino acid, or any N-methylamino acid or absent

<400>  349

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  350
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Opioid agonist peptide formula


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form aspartic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Any amino acid, or any N-methylamino acid or absent

<400>  350

Xaa Asp Gly Xaa Xaa 
1               5   


<210>  351
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Opioid agonist peptide formula


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Any amino acid, or any N-methylamino acid or absent

<400>  351

Xaa Thr Gly Xaa Xaa 
1               5   


<210>  352
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Opioid agonist peptide formula


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,6-Dimethyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form glutamic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Any amino acid, or any N-methylamino acid or absent

<400>  352

Xaa Glu Gly Xaa Xaa 
1               5   


<210>  353
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Opioid agonist peptide formula


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Any amino acid, or any N-methylamino acid or absent

<400>  353

Xaa Ala Gly Xaa Xaa 
1               5   


<210>  354
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Opioid agonist peptide formula


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form aspartic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Any amino acid, or any N-methylamino acid or absent

<400>  354

Xaa Asp Gly Xaa Xaa 
1               5   


<210>  355
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Opioid agonist peptide formula


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Any amino acid, or any N-methylamino acid or absent

<400>  355

Xaa Thr Gly Xaa Xaa 
1               5   


<210>  356
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Opioid agonist peptide formula


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Phe(2,6-dimethyl-4-CONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-form glutamic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Any amino acid, or any N-methylamino acid or absent

<400>  356

Xaa Glu Gly Xaa Xaa 
1               5   


<210>  357
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Opioid agonist peptide formula


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Tyr, DMT, or a Phe(4-COX) analog

<220>
<221>  MOD_RES
<222>  (2)..(3)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Sar, or bhF unsubstituted or substituted with 2-Me, 3-Me, 4-Me, 
       2-F, 3-F, 4-F, 2-Cl, 3-Cl, 4-Cl, 2-OH, 3-OH, or 4-OH

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  absent or any amino acid

<400>  357

Xaa Xaa Xaa Xaa Xaa 
1               5   


