                               SEQUENCE LISTING

<110> THE CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> COMPOSITIONS AND METHODS FOR TREATING FACIOSCAPULOHUMERAL 
      DYSTROPHY

<130> 167705.014401/PCT

<140> PCT/US2018/050043
<141> 2018-09-07

<150> 62/555,599
<151> 2017-09-07

<160> 3     

<170> PatentIn version 3.5

<210> 1
<211> 826
<212> PRT
<213> Homo sapiens

<400> 1
Met Glu Gly Ala Gly Gly Ala Asn Asp Lys Lys Lys Ile Ser Ser Glu 
1               5                   10                  15      


Arg Arg Lys Glu Lys Ser Arg Asp Ala Ala Arg Ser Arg Arg Ser Lys 
            20                  25                  30          


Glu Ser Glu Val Phe Tyr Glu Leu Ala His Gln Leu Pro Leu Pro His 
        35                  40                  45              


Asn Val Ser Ser His Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile 
    50                  55                  60                  


Ser Tyr Leu Arg Val Arg Lys Leu Leu Asp Ala Gly Asp Leu Asp Ile 
65                  70                  75                  80  


Glu Asp Asp Met Lys Ala Gln Met Asn Cys Phe Tyr Leu Lys Ala Leu 
                85                  90                  95      


Asp Gly Phe Val Met Val Leu Thr Asp Asp Gly Asp Met Ile Tyr Ile 
            100                 105                 110         


Ser Asp Asn Val Asn Lys Tyr Met Gly Leu Thr Gln Phe Glu Leu Thr 
        115                 120                 125             


Gly His Ser Val Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Met 
    130                 135                 140                 


Arg Glu Met Leu Thr His Arg Asn Gly Leu Val Lys Lys Gly Lys Glu 
145                 150                 155                 160 


Gln Asn Thr Gln Arg Ser Phe Phe Leu Arg Met Lys Cys Thr Leu Thr 
                165                 170                 175     


Ser Arg Gly Arg Thr Met Asn Ile Lys Ser Ala Thr Trp Lys Val Leu 
            180                 185                 190         


His Cys Thr Gly His Ile His Val Tyr Asp Thr Asn Ser Asn Gln Pro 
        195                 200                 205             


Gln Cys Gly Tyr Lys Lys Pro Pro Met Thr Cys Leu Val Leu Ile Cys 
    210                 215                 220                 


Glu Pro Ile Pro His Pro Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys 
225                 230                 235                 240 


Thr Phe Leu Ser Arg His Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp 
                245                 250                 255     


Glu Arg Ile Thr Glu Leu Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly 
            260                 265                 270         


Arg Ser Ile Tyr Glu Tyr Tyr His Ala Leu Asp Ser Asp His Leu Thr 
        275                 280                 285             


Lys Thr His His Asp Met Phe Thr Lys Gly Gln Val Thr Thr Gly Gln 
    290                 295                 300                 


Tyr Arg Met Leu Ala Lys Arg Gly Gly Tyr Val Trp Val Glu Thr Gln 
305                 310                 315                 320 


Ala Thr Val Ile Tyr Asn Thr Lys Asn Ser Gln Pro Gln Cys Ile Val 
                325                 330                 335     


Cys Val Asn Tyr Val Val Ser Gly Ile Ile Gln His Asp Leu Ile Phe 
            340                 345                 350         


Ser Leu Gln Gln Thr Glu Cys Val Leu Lys Pro Val Glu Ser Ser Asp 
        355                 360                 365             


Met Lys Met Thr Gln Leu Phe Thr Lys Val Glu Ser Glu Asp Thr Ser 
    370                 375                 380                 


Ser Leu Phe Asp Lys Leu Lys Lys Glu Pro Asp Ala Leu Thr Leu Leu 
385                 390                 395                 400 


Ala Pro Ala Ala Gly Asp Thr Ile Ile Ser Leu Asp Phe Gly Ser Asn 
                405                 410                 415     


Asp Thr Glu Thr Asp Asp Gln Gln Leu Glu Glu Val Pro Leu Tyr Asn 
            420                 425                 430         


Asp Val Met Leu Pro Ser Pro Asn Glu Lys Leu Gln Asn Ile Asn Leu 
        435                 440                 445             


Ala Met Ser Pro Leu Pro Thr Ala Glu Thr Pro Lys Pro Leu Arg Ser 
    450                 455                 460                 


Ser Ala Asp Pro Ala Leu Asn Gln Glu Val Ala Leu Lys Leu Glu Pro 
465                 470                 475                 480 


Asn Pro Glu Ser Leu Glu Leu Ser Phe Thr Met Pro Gln Ile Gln Asp 
                485                 490                 495     


Gln Thr Pro Ser Pro Ser Asp Gly Ser Thr Arg Gln Ser Ser Pro Glu 
            500                 505                 510         


Pro Asn Ser Pro Ser Glu Tyr Cys Phe Tyr Val Asp Ser Asp Met Val 
        515                 520                 525             


Asn Glu Phe Lys Leu Glu Leu Val Glu Lys Leu Phe Ala Glu Asp Thr 
    530                 535                 540                 


Glu Ala Lys Asn Pro Phe Ser Thr Gln Asp Thr Asp Leu Asp Leu Glu 
545                 550                 555                 560 


Met Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu Arg Ser 
                565                 570                 575     


Phe Asp Gln Leu Ser Pro Leu Glu Ser Ser Ser Ala Ser Pro Glu Ser 
            580                 585                 590         


Ala Ser Pro Gln Ser Thr Val Thr Val Phe Gln Gln Thr Gln Ile Gln 
        595                 600                 605             


Glu Pro Thr Ala Asn Ala Thr Thr Thr Thr Ala Thr Thr Asp Glu Leu 
    610                 615                 620                 


Lys Thr Val Thr Lys Asp Arg Met Glu Asp Ile Lys Ile Leu Ile Ala 
625                 630                 635                 640 


Ser Pro Ser Pro Thr His Ile His Lys Glu Thr Thr Ser Ala Thr Ser 
                645                 650                 655     


Ser Pro Tyr Arg Asp Thr Gln Ser Arg Thr Ala Ser Pro Asn Arg Ala 
            660                 665                 670         


Gly Lys Gly Val Ile Glu Gln Thr Glu Lys Ser His Pro Arg Ser Pro 
        675                 680                 685             


Asn Val Leu Ser Val Ala Leu Ser Gln Arg Thr Thr Val Pro Glu Glu 
    690                 695                 700                 


Glu Leu Asn Pro Lys Ile Leu Ala Leu Gln Asn Ala Gln Arg Lys Arg 
705                 710                 715                 720 


Lys Met Glu His Asp Gly Ser Leu Phe Gln Ala Val Gly Ile Gly Thr 
                725                 730                 735     


Leu Leu Gln Gln Pro Asp Asp His Ala Ala Thr Thr Ser Leu Ser Trp 
            740                 745                 750         


Lys Arg Val Lys Gly Cys Lys Ser Ser Glu Gln Asn Gly Met Glu Gln 
        755                 760                 765             


Lys Thr Ile Ile Leu Ile Pro Ser Asp Leu Ala Cys Arg Leu Leu Gly 
    770                 775                 780                 


Gln Ser Met Asp Glu Ser Gly Leu Pro Gln Leu Thr Ser Tyr Asp Cys 
785                 790                 795                 800 


Glu Val Asn Ala Pro Ile Gln Gly Ser Arg Asn Leu Leu Gln Gly Glu 
                805                 810                 815     


Glu Leu Leu Arg Ala Leu Asp Gln Val Asn 
            820                 825     


<210> 2
<211> 3979
<212> DNA
<213> Homo sapiens

<400> 2
atttgaaaac ttggcaacct tggattggat ggattcatat ttcttagtat agaagttctt       60

gatataactg aaaaattaag ttaaacactt aataagtggt ggttactcag cacttttaga      120

tgctgtttat aatagatgac cttttctaac taatttacag ttttttgaaa gataactgag      180

aggttgaggg acggagattt tcttcaagca attttttttt tcattttaaa tgagctccca      240

atgtcggagt ttggaaaaca aatttgtctt tttaaaagaa ggtctaggaa actcaaaacc      300

tgaagaattg gaagaaatca gaatagaaaa tggtaggata agttctgaac gtcgaaaaga      360

aaagtctcga gatgcagcca gatctcggcg aagtaaagaa tctgaagttt tttatgagct      420

tgctcatcag ttgccacttc cacataatgt gagttcgcat cttgataagg cctctgtgat      480

gaggcttacc atcagctatt tgcgtgtgag gaaacttctg gatgctggtg atttggatat      540

tgaagatgac atgaaagcac agatgaattg cttttatttg aaagccttgg atggttttgt      600

tatggttctc acagatgatg gtgacatgat ttacatttct gataatgtga acaaatacat      660

gggattaact cagtttgaac taactggaca cagtgtgttt gattttactc atccatgtga      720

ccatgaggaa atgagagaaa tgcttacaca cagaaatggc cttgtgaaaa agggtaaaga      780

acaaaacaca cagcgaagct tttttctcag aatgaagtgt accctaacta gccgaggaag      840

aactatgaac ataaagtctg caacatggaa ggtattgcac tgcacaggcc acattcacgt      900

atatgatacc aacagtaacc aacctcagtg tgggtataag aaaccaccta tgacctgctt      960

ggtgctgatt tgtgaaccca ttcctcaccc atcaaatatt gaaattcctt tagatagcaa     1020

gactttcctc agtcgacaca gcctggatat gaaattttct tattgtgatg aaagaattac     1080

cgaattgatg ggatatgagc cagaagaact tttaggccgc tcaatttatg aatattatca     1140

tgctttggac tctgatcatc tgaccaaaac tcatcatgat atgtttacta aaggacaagt     1200

caccacagga cagtacagga tgcttgccaa aagaggtgga tatgtctggg ttgaaactca     1260

agcaactgtc atatataaca ccaagaattc tcaaccacag tgcattgtat gtgtgaatta     1320

cgttgtgagt ggtattattc agcacgactt gattttctcc cttcaacaaa cagaatgtgt     1380

ccttaaaccg gttgaatctt cagatatgaa aatgactcag ctattcacca aagttgaatc     1440

agaagataca agtagcctct ttgacaaact taagaaggaa cctgatgctt taactttgct     1500

ggccccagcc gctggagaca caatcatatc tttagatttt ggcagcaacg acacagaaac     1560

tgatgaccag caacttgagg aagtaccatt atataatgat gtaatgctcc cctcacccaa     1620

cgaaaaatta cagaatataa atttggcaat gtctccatta cccaccgctg aaacgccaaa     1680

gccacttcga agtagtgctg accctgcact caatcaagaa gttgcattaa aattagaacc     1740

aaatccagag tcactggaac tttcttttac catgccccag attcaggatc agacacctag     1800

tccttccgat ggaagcacta gacaaagttc acctgagcct aatagtccca gtgaatattg     1860

tttttatgtg gatagtgata tggtcaatga attcaagttg gaattggtag aaaaactttt     1920

tgctgaagac acagaagcaa agaacccatt ttctactcag gacacagatt tagacttgga     1980

gatgttagct ccctatatcc caatggatga tgacttccag ttacgttcct tcgatcagtt     2040

gtcaccatta gaaagcagtt ccgcaagccc tgaaagcgca agtcctcaaa gcacagttac     2100

agtattccag cagactcaaa tacaagaacc tactgctaat gccaccacta ccactgccac     2160

cactgatgaa ttaaaaacag tgacaaaaga ccgtatggaa gacattaaaa tattgattgc     2220

atctccatct cctacccaca tacataaaga aactactagt gccacatcat caccatatag     2280

agatactcaa agtcggacag cctcaccaaa cagagcagga aaaggagtca tagaacagac     2340

agaaaaatct catccaagaa gccctaacgt gttatctgtc gctttgagtc aaagaactac     2400

agttcctgag gaagaactaa atccaaagat actagctttg cagaatgctc agagaaagcg     2460

aaaaatggaa catgatggtt cactttttca agcagtagga attggaacat tattacagca     2520

gccagacgat catgcagcta ctacatcact ttcttggaaa cgtgtaaaag gatgcaaatc     2580

tagtgaacag aatggaatgg agcaaaagac aattatttta ataccctctg atttagcatg     2640

tagactgctg gggcaatcaa tggatgaaag tggattacca cagctgacca gttatgattg     2700

tgaagttaat gctcctatac aaggcagcag aaacctactg cagggtgaag aattactcag     2760

agctttggat caagttaact gagctttttc ttaatttcat tccttttttt ggacactggt     2820

ggctcattac ctaaagcagt ctatttatat tttctacatc taattttaga agcctggcta     2880

caatactgca caaacttggt tagttcaatt ttgatcccct ttctacttaa tttacattaa     2940

tgctcttttt tagtatgttc tttaatgctg gatcacagac agctcatttt ctcagttttt     3000

tggtatttaa accattgcat tgcagtagca tcattttaaa aaatgcacct ttttatttat     3060

ttatttttgg ctagggagtt tatccctttt tcgaattatt tttaagaaga tgccaatata     3120

atttttgtaa gaaggcagta acctttcatc atgatcatag gcagttgaaa aatttttaca     3180

cctttttttt cacattttac ataaataata atgctttgcc agcagtacgt ggtagccaca     3240

attgcacaat atattttctt aaaaaatacc agcagttact catggaatat attctgcgtt     3300

tataaaacta gtttttaaga agaaattttt tttggcctat gaaattgtta aacctggaac     3360

atgacattgt taatcatata ataatgattc ttaaatgctg tatggtttat tatttaaatg     3420

ggtaaagcca tttacataat atagaaagat atgcatatat ctagaaggta tgtggcattt     3480

atttggataa aattctcaat tcagagaaat catctgatgt ttctatagtc actttgccag     3540

ctcaaaagaa aacaataccc tatgtagttg tggaagttta tgctaatatt gtgtaactga     3600

tattaaacct aaatgttctg cctaccctgt tggtataaag atattttgag cagactgtaa     3660

acaagaaaaa aaaaatcatg cattcttagc aaaattgcct agtatgttaa tttgctcaaa     3720

atacaatgtt tgattttatg cactttgtcg ctattaacat cctttttttc atgtagattt     3780

caataattga gtaattttag aagcattatt ttaggaatat atagttgtca cagtaaatat     3840

cttgtttttt ctatgtacat tgtacaaatt tttcattcct tttgctcttt gtggttggat     3900

ctaacactaa ctgtattgtt ttgttacatc aaataaacat cttctgtgga ccaggcaaaa     3960

aaaaaaaaaa aaaaaaaaa                                                  3979


<210> 3
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Caspase 3 inhibitor peptide

<400> 3
Asp Glu Val Asp 
1               


