                         SEQUENCE LISTING

<110>  Cue Biopharma, Inc.
 
<120>  T-Cell Modulatory Multimeric Polypeptide with Conjugation Sites 
       and Methods of Use Thereof

<130>  123640-8001.WO00

<150>  US 62/555,559
<151>  2017-09-07

<150>  US62/609,082
<151>  2017-12-21

<150>  US 62/615,402
<151>  2018-01-09

<160>  170   

<170>  PatentIn version 3.5

<210>  1
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  2
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
1               5                   10                  15      


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
            20                  25                  30          


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
        35                  40                  45              


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
    50                  55                  60                  


Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr 
65                  70                  75                  80  


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr 
                85                  90                  95      


Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
            100                 105                 110         


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        115                 120                 125             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    130                 135                 140                 


Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
145                 150                 155                 160 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
                165                 170                 175     


Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
            180                 185                 190         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
        195                 200                 205             


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
    210                 215                 220                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
225                 230                 235                 240 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                245                 250                 255     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            260                 265                 270         


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        275                 280                 285             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    290                 295                 300                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
305                 310                 315                 320 


Leu Ser Pro Gly Lys 
                325 


<210>  3
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  3

His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Leu Lys Thr 
1               5                   10                  15      


Pro Leu Gly Asp Thr Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
145                 150                 155                 160 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            180                 185                 190         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        195                 200                 205             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly Lys 
                245     


<210>  4
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  4

Pro Thr Lys Ala Pro Asp Val Phe Pro Ile Ile Ser Gly Cys Arg His 
1               5                   10                  15      


Pro Lys Asp Asn Ser Pro Val Val Leu Ala Cys Leu Ile Thr Gly Tyr 
            20                  25                  30          


His Pro Thr Ser Val Thr Val Thr Trp Tyr Met Gly Thr Gln Ser Gln 
        35                  40                  45              


Pro Gln Arg Thr Phe Pro Glu Ile Gln Arg Arg Asp Ser Tyr Tyr Met 
    50                  55                  60                  


Thr Ser Ser Gln Leu Ser Thr Pro Leu Gln Gln Trp Arg Gln Gly Glu 
65                  70                  75                  80  


Tyr Lys Cys Val Val Gln His Thr Ala Ser Lys Ser Lys Lys Glu Ile 
                85                  90                  95      


Phe Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr 
            100                 105                 110         


Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro 
        115                 120                 125             


Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu 
    130                 135                 140                 


Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys 
145                 150                 155                 160 


Pro Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val 
                165                 170                 175     


Gln Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val 
            180                 185                 190         


Gly Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys 
        195                 200                 205             


Val Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn 
    210                 215                 220                 


Gly Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp 
225                 230                 235                 240 


Asn Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro 
                245                 250                 255     


Pro Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val 
            260                 265                 270         


Lys Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala 
        275                 280                 285             


Ser Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu 
    290                 295                 300                 


Leu Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala 
305                 310                 315                 320 


Pro Ala Arg Pro Pro Pro Gln Pro Arg Ser Thr Thr Phe Trp Ala Trp 
                325                 330                 335     


Ser Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr 
            340                 345                 350         


Thr Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser 
        355                 360                 365             


Arg Ser Leu Glu Val Ser Tyr Val Thr Asp His Gly Pro Met Lys 
    370                 375                 380             


<210>  5
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  5

Val Thr Ser Thr Leu Thr Ile Lys Glx Ser Asp Trp Leu Gly Glu Ser 
1               5                   10                  15      


Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln Asn 
            20                  25                  30          


Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val Phe 
        35                  40                  45              


Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr Lys 
    50                  55                  60                  


Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asx Ser Val Thr Ile 
65                  70                  75                  80  


Ser Trp Thr Arg Glu Glu Asn Gly Ala Val Lys Thr His Thr Asn Ile 
                85                  90                  95      


Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala Ser 
            100                 105                 110         


Ile Cys Glu Asp Asx Asp Trp Ser Gly Glu Arg Phe Thr Cys Thr Val 
        115                 120                 125             


Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg Pro 
    130                 135                 140                 


Lys Gly Val Ala Leu His Arg Pro Asx Val Tyr Leu Leu Pro Pro Ala 
145                 150                 155                 160 


Arg Glx Glx Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu Val 
                165                 170                 175     


Thr Gly Phe Ser Pro Ala Asp Val Phe Val Glu Trp Met Gln Arg Gly 
            180                 185                 190         


Glu Pro Leu Ser Pro Gln Lys Tyr Val Thr Ser Ala Pro Met Pro Glu 
        195                 200                 205             


Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val Ser 
    210                 215                 220                 


Glu Glu Glu Trp Asn Thr Gly Gly Thr Tyr Thr Cys Val Val Ala His 
225                 230                 235                 240 


Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr 
                245                 250                 255     


Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala 
            260                 265                 270         


Gly Thr Cys Tyr 
        275     


<210>  6
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr 
1               5                   10                  15      


Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro 
            100                 105                 110         


Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser 
        115                 120                 125             


Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn 
    130                 135                 140                 


Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe 
145                 150                 155                 160 


Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu 
                165                 170                 175     


Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys 
            180                 185                 190         


Ala Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr 
        195                 200                 205             


Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn 
    210                 215                 220                 


Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu 
225                 230                 235                 240 


Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser 
                245                 250                 255     


Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro 
            260                 265                 270         


Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly 
        275                 280                 285             


Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp 
    290                 295                 300                 


Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu 
305                 310                 315                 320 


Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro 
                325                 330                 335     


Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys 
            340                 345                 350         


Tyr 
    


<210>  7
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  7

Ala Asp Pro Cys Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser 
1               5                   10                  15      


Arg Pro Ser Pro Phe Asp Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr 
            20                  25                  30          


Cys Leu Val Val Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr 
        35                  40                  45              


Trp Ser Arg Ala Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu 
    50                  55                  60                  


Glu Lys Gln Arg Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Pro Val 
65                  70                  75                  80  


Gly Thr Arg Asp Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr 
                85                  90                  95      


His Pro His Leu Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser 
            100                 105                 110         


Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp 
        115                 120                 125             


Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe 
    130                 135                 140                 


Met Pro Glu Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu 
145                 150                 155                 160 


Pro Asp Ala Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser 
                165                 170                 175     


Gly Phe Phe Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu 
            180                 185                 190         


Gln Lys Asp Glu Phe Ile Cys Arg Ala Val His Glu Ala Ala Ser Pro 
        195                 200                 205             


Ser Gln Thr Val Gln Arg Ala Val Ser Val Asn Pro Gly Lys 
    210                 215                 220         


<210>  8
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  9
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  9

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  10
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  10

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  11
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  11

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  12
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  12

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  13
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile Cys Leu Thr 
225                 230                 235                 240 


Leu Ser Pro Ser Thr 
                245 


<210>  14
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  14

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile 
    210                 215                 


<210>  15
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  15

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly Leu Leu Gly Ser 
145                 150                 155                 160 


Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys Ser Arg Ala Ala 
                165                 170                 175     


Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp 
            180                 185                 190         


Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe 
        195                 200                 205             


Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu 
    210                 215                 220                 


Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser 
225                 230                 235                 240 


Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro 
                245                 250                 255     


Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
            260                 265             


<210>  16
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  16

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  17
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  18
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Trp Lys His Leu Cys Pro Ser Pro Leu 
        35                  40                  45              


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
    50                  55                  60                  


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
65                  70                  75                  80  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
                85                  90                  95      


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
            100                 105                 110         


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        115                 120             


<210>  19
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
            20                  25                  30          


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
        35                  40                  45              


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
    50                  55                  60                  


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
65                  70                  75                  80  


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
                85                  90                  95      


Ala Ala Tyr Arg Ser 
            100     


<210>  20
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  20

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Asn Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
            100                 105                 110         


Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val 
        115                 120                 125             


Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys 
    130                 135                 140                 


Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp 
145                 150                 155                 160 


Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val 
                165                 170                 175     


Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr 
            180                 185                 190         


Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro 
        195                 200                 205             


Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro 
    210                 215                 220                 


<210>  21
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  21

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Asn Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu 
            100                 105                 110 


<210>  22
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210>  23
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  23

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
1               5                   10                  15      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            20                  25                  30          


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        35                  40                  45              


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    50                  55                  60                  


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
65                  70                  75                  80  


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                85                  90                  95      


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            100                 105                 110         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        115                 120                 125             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    130                 135                 140                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
145                 150                 155                 160 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                165                 170                 


<210>  24
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  24

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                165                 170                 175 


<210>  25
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  25

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala 
                165         


<210>  26
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  27
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  27

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  28
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  28

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln Val Ala Val Ala Gly 
    210                 215                 220                 


Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu Ser Gly Leu Thr Trp 
225                 230                 235                 240 


Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
                245                 250     


<210>  29
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  29

Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn 
1               5                   10                  15      


Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys 
            20                  25                  30          


Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu 
        35                  40                  45              


Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly 
    50                  55                  60                  


Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg 
65                  70                  75                  80  


Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp 
                85                  90                  95      


Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln 
            100                 105                 110         


Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser 
        115                 120                 125             


Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr 
    130                 135                 140                 


Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys 
145                 150                 155                 160 


Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln 
                165                 170                 175     


Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr 
            180                 185                 190         


Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala 
        195                 200                 205             


Leu Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu 
    210                 215                 220                 


Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys 
225                 230                 235                 240 


Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro 
                245                 250                 255     


Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp 
            260                 265                 270         


Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro 
        275                 280                 285             


Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp 
    290                 295                 300                 


Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala 
305                 310                 315                 320 


Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly 
                325                 330                 335     


Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln 
            340                 345                 350         


Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly 
        355                 360                 365             


Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu 
    370                 375                 380                 


Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu 
385                 390                 395                 400 


Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr 
                405                 410                 415     


Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu 
            420                 425                 430         


Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro 
        435                 440                 445             


Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu 
    450                 455                 460                 


Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu 
465                 470                 475                 480 


Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg 
                485                 490                 495     


Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu 
            500                 505                 510         


Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        515                 520                 


<210>  30
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  30

Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly Asn Glu Asp Thr Thr Ala 
1               5                   10                  15      


Asp Phe Phe Leu Thr Thr Met Pro Thr Asp Ser Leu Ser Val Ser Thr 
            20                  25                  30          


Leu Pro Leu Pro Glu Val Gln Cys Phe Val Phe Asn Val Glu Tyr Met 
        35                  40                  45              


Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro Gln Pro Thr Asn Leu Thr 
    50                  55                  60                  


Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn Asp Lys Val Gln Lys Cys 
65                  70                  75                  80  


Ser His Tyr Leu Phe Ser Glu Glu Ile Thr Ser Gly Cys Gln Leu Gln 
                85                  90                  95      


Lys Lys Glu Ile His Leu Tyr Gln Thr Phe Val Val Gln Leu Gln Asp 
            100                 105                 110         


Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln Met Leu Lys Leu Gln Asn 
        115                 120                 125             


Leu Val Ile Pro Trp Ala Pro Glu Asn Leu Thr Leu His Lys Leu Ser 
    130                 135                 140                 


Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn Arg Phe Leu Asn His Cys 
145                 150                 155                 160 


Leu Glu His Leu Val Gln Tyr Arg Thr Asp Trp Asp His Ser Trp Thr 
                165                 170                 175     


Glu Gln Ser Val Asp Tyr Arg His Lys Phe Ser Leu Pro Ser Val Asp 
            180                 185                 190         


Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg Ser Arg Phe Asn Pro Leu 
        195                 200                 205             


Cys Gly Ser Ala Gln His Trp Ser Glu Trp Ser His Pro Ile His Trp 
    210                 215                 220                 


Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe Ala Leu Glu Ala 
225                 230                 235                 240 


Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys 
                245                 250                 255     


Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys 
            260                 265                 270         


Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp 
        275                 280                 285             


Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser 
    290                 295                 300                 


Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu 
305                 310                 315                 320 


Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp 
                325                 330                 335     


Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr 
            340                 345         


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope tag

<400>  31

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope tag

<400>  32

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope tag

<400>  33

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5x His Tag

<400>  34

His His His His His 
1               5   


<210>  35
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6x His Tag

<400>  35

His His His His His His 
1               5       


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STREP TAG

<400>  36

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cellulose binding domain

<400>  37

Arg Tyr Ile Arg Ser 
1               5   


<210>  38
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phe-His-His-Thr

<400>  38

Phe His His Thr 
1               


<210>  39
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WEAAAREACCRECCAR PEPTIDE

<400>  39

Trp Glu Ala Ala Ala Arg Glu Ala Cys Cys Arg Glu Cys Cys Ala Arg 
1               5                   10                  15      


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LEVLFQGP CLEVAGE SITE

<400>  40

Leu Glu Val Leu Phe Gln Gly Pro 
1               5               


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENLYTQS CLEAVAGE SITE

<400>  41

Glu Asn Leu Tyr Thr Gln Ser 
1               5           


<210>  42
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDDDK CLEVAGE SITE

<400>  42

Asp Asp Asp Asp Lys 
1               5   


<210>  43
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   LVPR CLEVAGE SITE

<400>  43

Leu Val Pro Arg 
1               


<210>  44
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSGATNFSLLKQAGDVEENPGP CLEVAGE SITE

<400>  44

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  45
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SULFATASE MOTIF


<220>
<221>  UNSURE
<222>  (1)..(1)
<223>  Xaa is present or absent, and when present, can be any amino 
       acid, though usually an aliphatic, a sulfur-containing , or a 
       polar, uncharged amino acid (e.g.., other than an aromatic amino 
       acid or a charged amino acid), usually L, M, V, S or T

<220>
<221>  UNSURE
<222>  (2)..(2)
<223>  Xaa is cysteine or serine

<220>
<221>  UNSURE
<222>  (3)..(3)
<223>  Xaa is any amino acid, though usually an aliphatic amino acid, a 
       polar uncharged amino acid, or a sulfur containing amino acid 
       (e.g., other than an aromatic amino acid or charged amino acid), 
       usually S, T, A, V, G or C.

<220>
<221>  UNSURE
<222>  (4)..(4)
<223>  Xaa is proline or alanine

<220>
<221>  UNSURE
<222>  (5)..(5)
<223>  Xaa is any amino acid, though usually an aliphatic amino acid, a 
       polar uncharged amino acid, or a sulfur containing amino acid 
       (e.g., other than an aromatic amino acid or charged amino acid), 
       usually S, T, A, V, G or C.

<220>
<221>  UNSURE
<222>  (6)..(6)
<223>  Xaa is a basic amino acid (arginine, lysine, or histidine, 
       usually lysine), or an aliphatic amino acid (alanine, glycine, 
       leucine, valine, isoleucine, or proline, usually A, G, L, V, or 
       I.

<400>  45

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  46
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SULFATASE MOTIF


<220>
<221>  UNSURE
<222>  (1)..(1)
<223>  Xaa is cysteine or serine.

<220>
<221>  UNSURE
<222>  (2)..(2)
<223>  Xaa is any amino acid, though usually an aliphatic amino acid, a 
       polar uncharged amino acid, or a sulfur containing amino acid 
       (i.e., other than an aromatic amino acid or charged amino acid), 
       usually S, T, A, V, G or C.

<220>
<221>  UNSURE
<222>  (2)..(2)
<223>  Xaa is proline or alanine.

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  UNSURE
<222>  (4)..(4)
<223>  Xaa is any amino acid, though usually an aliphatic amino acid, a 
       polar uncharged amino acid, or a sulfur containing amino acid 
       (i.e., other than an aromatic amino acid or charged amino acid), 
       usually S, T, A, V, G or C

<220>
<221>  UNSURE
<222>  (5)..(5)
<223>  Xaa is a basic amino acid (arginine, lysine, or histidine, 
       usually lysine), or an aliphatic amino acid (alanine, glycine, 
       leucine, valine, isoleucine, or proline, usually A, G, L, V, or 
       I).

<400>  46

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  47
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SULFATASE MOTIF


<220>
<221>  UNSURE
<222>  (1)..(1)
<223>  Xaa is present or absent, and when present, can be any amino 
       acid, though usually an aliphatic, a sulfur-containing , or a 
       polar, uncharged amino acid (e.g.., other than an aromatic amino 
       acid or a charged amino acid), usually L, M, V, S or T

<220>
<221>  UNSURE
<222>  (3)..(3)
<223>  Xaa is any amino acid, though usually an aliphatic amino acid, a 
       polar uncharged amino acid, or a sulfur containing amino acid 
       (e.g., other than an aromatic amino acid or charged amino acid), 
       usually S, T, A, V, G or C.

<220>
<221>  UNSURE
<222>  (5)..(5)
<223>  Xaa is any amino acid, though usually an aliphatic amino acid, a 
       polar uncharged amino acid, or a sulfur containing amino acid 
       (e.g., other than an aromatic amino acid or charged amino acid), 
       usually S, T, A, V, G or C.

<220>
<221>  UNSURE
<222>  (6)..(6)
<223>  Xaa is a basic amino acid (arginine, lysine, or histidine, 
       usually lysine), or an aliphatic amino acid (alanine, glycine, 
       leucine, valine, isoleucine, or proline, usually A, G, L, V, or 
       I.

<400>  47

Xaa Cys Xaa Pro Xaa Xaa 
1               5       


<210>  48
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SULFATASE MOTIF


<220>
<221>  UNSURE
<222>  (2)..(2)
<223>  Xaa is any amino acid, though usually an aliphatic amino acid, a 
       polar uncharged amino acid, or a sulfur containing amino acid 
       (e.g., other than an aromatic amino acid or charged amino acid), 
       usually S, T, A, V, G or C.

<220>
<221>  UNSURE
<222>  (4)..(4)
<223>  Xaa is any amino acid, though usually an aliphatic amino acid, a 
       polar uncharged amino acid, or a sulfur containing amino acid 
       (e.g., other than an aromatic amino acid or charged amino acid), 
       usually S, T, A, V, G or C.

<220>
<221>  UNSURE
<222>  (5)..(5)
<223>  Xaa is a basic amino acid (arginine, lysine, or histidine, 
       usually lysine), or an aliphatic amino acid (alanine, glycine, 
       leucine, valine, isoleucine, or proline, usually A, G, L, V, or 
       I.

<400>  48

Cys Xaa Pro Xaa Xaa 
1               5   


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AUXILIARY SULFATASE MOTIF

<400>  49

Ala Ala Leu Leu Thr Gly Arg 
1               5           


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AUXILIARY SULFATASE MOTIF

<400>  50

Ser Gln Leu Leu Thr Gly Arg 
1               5           


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AUXILIARY SULFATASE MOTIF

<400>  51

Ala Ala Phe Met Thr Gly Arg 
1               5           


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AUXILIARY SULFATASE MOTIF

<400>  52

Ala Ala Phe Leu Thr Gly Arg 
1               5           


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AUXILIARY SULFATASE MOTIF

<400>  53

Gly Ser Leu Phe Thr Gly Arg 
1               5           


<210>  54
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SORTASE SITE


<220>
<221>  UNSURE
<222>  (3)..(3)
<223>  Xaa is any amino acide.

<220>
<221>  UNSURE
<222>  (5)..(5)
<223>  Xaa is glycine or alanine.

<400>  54

Leu Pro Xaa Thr Xaa 
1               5   


<210>  55
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5X Glycine

<400>  55

Gly Gly Gly Gly Gly 
1               5   


<210>  56
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4X Glycine

<400>  56

Gly Gly Gly Gly 
1               


<210>  57
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5X Alanine

<400>  57

Ala Ala Ala Ala Ala 
1               5   


<210>  58
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4X Alanine

<400>  58

Ala Ala Ala Ala 
1               


<210>  59
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LPETGG  SORTASE SITE

<400>  59

Leu Pro Glu Thr Gly Gly 
1               5       


<210>  60
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LPETAA  SORTASE SITE

<400>  60

Leu Pro Glu Thr Ala Ala 
1               5       


<210>  61
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  THROMBIN CLEAVAGE SITE

<400>  61

Leu Val Pro Arg Gly 
1               5   


<210>  62
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRANSGLUTAMINASE SITE

<400>  62

Leu Leu Gln Gly Gly 
1               5   


<210>  63
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRANSGLUTAMINASE SITE

<400>  63

Leu Leu Gln Gly 
1               


<210>  64
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRANSGLUTAMINASE SITE

<400>  64

Leu Ser Leu Ser Gln Gly 
1               5       


<210>  65
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRANSGLUTAMINASE SITE

<400>  65

Leu Leu Gln Leu Gln Gly 
1               5       


<210>  66
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSGGS PEPTIDE

<400>  66

Gly Ser Gly Gly Ser 
1               5   


<210>  67
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGGS PEPTIDE

<400>  67

Gly Gly Gly Ser 
1               


<210>  68
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGSG PEPTIDE

<400>  68

Gly Gly Ser Gly 
1               


<210>  69
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGSGG PEPTIDE

<400>  69

Gly Gly Ser Gly Gly 
1               5   


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSGSG PEPTIDE

<400>  70

Gly Ser Gly Ser Gly 
1               5   


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSGGG PEPTIDE

<400>  71

Gly Ser Gly Gly Gly 
1               5   


<210>  72
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGGSG PEPTIDE

<400>  72

Gly Gly Gly Ser Gly 
1               5   


<210>  73
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSSSG PEPTIDE

<400>  73

Gly Ser Ser Ser Gly 
1               5   


<210>  74
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSSSS PEPTIDE

<400>  74

Gly Ser Ser Ser Ser 
1               5   


<210>  75
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAAGG PEPTIDE

<400>  75

Ala Ala Ala Gly Gly 
1               5   


<210>  76
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGGGS PEPTIDE

<400>  76

Gly Gly Gly Gly Ser 
1               5   


<210>  77
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCGASGGGGSGGGGS PEPTIDE

<400>  77

Gly Cys Gly Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  78
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCGGSGGGGSGGGGSGGGGS PEPTIDE

<400>  78

Gly Cys Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  79
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCGGSGGGGSGGGGS PEPTIDE

<400>  79

Gly Cys Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  80
<211>  9
<212>  PRT
<213>  Human papillomavirus type 16

<400>  80

Leu Leu Met Gly Thr Leu Gly Ile Val 
1               5                   


<210>  81
<211>  8
<212>  PRT
<213>  Human papillomavirus type 16

<400>  81

Thr Leu Gly Ile Val Cys Pro Ile 
1               5               


<210>  82
<211>  10
<212>  PRT
<213>  Human papillomavirus type 16

<400>  82

Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr 
1               5                   10  


<210>  83
<211>  9
<212>  PRT
<213>  Human papillomavirus type 16

<400>  83

Tyr Met Leu Asp Leu Gln Pro Glu Thr 
1               5                   


<210>  84
<211>  10
<212>  PRT
<213>  Hepatitis B virus

<400>  84

Phe Leu Pro Ser Asp Phe Phe Pro Ser Val 
1               5                   10  


<210>  85
<211>  10
<212>  PRT
<213>  Hepatitis B virus

<400>  85

Gly Leu Ser Arg Tyr Val Ala Arg Leu Gly 
1               5                   10  


<210>  86
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  86

Lys Leu His Leu Tyr Ser His Pro Ile 
1               5                   


<210>  87
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  87

Phe Leu Leu Ser Leu Gly Ile His Leu 
1               5                   


<210>  88
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  88

Ala Leu Met Pro Leu Tyr Ala Cys Ile 
1               5                   


<210>  89
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  89

Ser Leu Tyr Ala Asp Ser Pro Ser Val 
1               5                   


<210>  90
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  90

Ser Thr Leu Pro Glu Thr Thr Val Val 
1               5                   


<210>  91
<211>  10
<212>  PRT
<213>  Hepatitis B virus

<400>  91

Leu Ile Met Pro Ala Arg Phe Tyr Pro Lys 
1               5                   10  


<210>  92
<211>  10
<212>  PRT
<213>  Hepatitis B virus

<400>  92

Ala Ile Met Pro Ala Arg Phe Tyr Pro Lys 
1               5                   10  


<210>  93
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  93

Tyr Val Asn Val Asn Met Gly Leu Lys 
1               5                   


<210>  94
<211>  8
<212>  PRT
<213>  Hepatitis B virus

<400>  94

Pro Leu Gly Phe Phe Pro Asp His 
1               5               


<210>  95
<211>  15
<212>  PRT
<213>  Hepatitis B virus

<400>  95

Met Gln Trp Asn Ser Thr Ala Leu His Gln Ala Leu Gln Asp Pro 
1               5                   10                  15  


<210>  96
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  96

Leu Leu Asp Pro Arg Val Arg Gly Leu 
1               5                   


<210>  97
<211>  10
<212>  PRT
<213>  Hepatitis B virus

<400>  97

Ser Ile Leu Ser Lys Thr Gly Asp Pro Val 
1               5                   10  


<210>  98
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  98

Val Leu Gln Ala Gly Phe Phe Leu Leu 
1               5                   


<210>  99
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  99

Phe Leu Leu Thr Arg Ile Leu Thr Ile 
1               5                   


<210>  100
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  100

Phe Leu Gly Gly Thr Pro Val Cys Leu 
1               5                   


<210>  101
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  101

Leu Leu Cys Leu Ile Phe Leu Leu Val 
1               5                   


<210>  102
<211>  10
<212>  PRT
<213>  Hepatitis B virus

<400>  102

Leu Val Leu Leu Asp Tyr Gln Gly Met Leu 
1               5                   10  


<210>  103
<211>  10
<212>  PRT
<213>  Hepatitis B virus

<400>  103

Leu Leu Asp Tyr Gln Gly Met Leu Pro Val 
1               5                   10  


<210>  104
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  104

Ile Pro Ile Pro Ser Ser Trp Ala Phe 
1               5                   


<210>  105
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  105

Trp Leu Ser Leu Leu Val Pro Phe Val 
1               5                   


<210>  106
<211>  10
<212>  PRT
<213>  Hepatitis B virus

<400>  106

Gly Leu Ser Pro Thr Val Trp Leu Ser Val 
1               5                   10  


<210>  107
<211>  10
<212>  PRT
<213>  Hepatitis B virus

<400>  107

Ser Ile Val Ser Pro Phe Ile Pro Leu Leu 
1               5                   10  


<210>  108
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  108

Ile Leu Ser Pro Phe Leu Pro Leu Leu 
1               5                   


<210>  109
<211>  17
<212>  PRT
<213>  Hepatitis B virus

<400>  109

Ala Thr Val Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser 
1               5                   10                  15      


Val 
    


<210>  110
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  110

Leu Pro Ser Asp Phe Phe Pro Ser Val 
1               5                   


<210>  111
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  111

Cys Leu Thr Phe Gly Arg Glu Thr Val 
1               5                   


<210>  112
<211>  10
<212>  PRT
<213>  Hepatitis B virus

<400>  112

Val Leu Glu Tyr Leu Val Ser Phe Gly Val 
1               5                   10  


<210>  113
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  113

Glu Tyr Leu Val Ser Phe Gly Val Trp 
1               5                   


<210>  114
<211>  10
<212>  PRT
<213>  Hepatitis B virus

<400>  114

Ile Leu Ser Thr Leu Pro Glu Thr Thr Val 
1               5                   10  


<210>  115
<211>  11
<212>  PRT
<213>  Hepatitis B virus

<400>  115

Ser Thr Leu Pro Glu Thr Thr Val Val Arg Arg 
1               5                   10      


<210>  116
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  116

Asn Val Ser Ile Pro Trp Thr His Lys 
1               5                   


<210>  117
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  117

Lys Val Gly Asn Phe Thr Gly Leu Tyr 
1               5                   


<210>  118
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  118

Gly Leu Tyr Ser Ser Thr Val Pro Val 
1               5                   


<210>  119
<211>  10
<212>  PRT
<213>  Hepatitis B virus

<400>  119

Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys 
1               5                   10  


<210>  120
<211>  10
<212>  PRT
<213>  Hepatitis B virus

<400>  120

Thr Pro Ala Arg Val Thr Gly Gly Val Phe 
1               5                   10  


<210>  121
<211>  10
<212>  PRT
<213>  Hepatitis B virus

<400>  121

Leu Val Val Asp Phe Ser Gln Phe Ser Arg 
1               5                   10  


<210>  122
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  122

Gly Leu Ser Arg Tyr Val Ala Arg Leu 
1               5                   


<210>  123
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  123

Ser Ile Ala Cys Ser Val Val Arg Arg 
1               5                   


<210>  124
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  124

Tyr Met Asp Asp Val Val Leu Gly Ala 
1               5                   


<210>  125
<211>  10
<212>  PRT
<213>  Hepatitis B virus

<400>  125

Gln Ala Phe Thr Phe Ser Pro Thr Tyr Lys 
1               5                   10  


<210>  126
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  126

Lys Tyr Thr Ser Phe Pro Trp Leu Leu 
1               5                   


<210>  127
<211>  10
<212>  PRT
<213>  Hepatitis B virus

<400>  127

Ile Leu Arg Gly Thr Ser Phe Val Tyr Val 
1               5                   10  


<210>  128
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  128

His Leu Ser Leu Arg Gly Leu Phe Val 
1               5                   


<210>  129
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  129

Val Leu His Lys Arg Thr Leu Gly Leu 
1               5                   


<210>  130
<211>  10
<212>  PRT
<213>  Hepatitis B virus

<400>  130

Gly Leu Ser Ala Met Ser Thr Thr Asp Leu 
1               5                   10  


<210>  131
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  131

Cys Leu Phe Lys Asp Trp Glu Glu Leu 
1               5                   


<210>  132
<211>  9
<212>  PRT
<213>  Hepatitis B virus

<400>  132

Val Leu Gly Gly Cys Arg His Lys Leu 
1               5                   


<210>  133
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LINKER SEQUENCE GCGGS(GGGGS)n where n is 1-9

<400>  133

Gly Cys Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  134
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Lys Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Met Lys Ala His Ser Gln 
                85                  90                  95      


Thr Asp Arg Ala Asn Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Val His Ala 
                165                 170                 175     


Ala Glu Gln Arg Arg Val Tyr Leu Glu Gly Arg Cys Val Asp Gly Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Thr Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210>  135
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Tyr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Val Lys Ala Gln Ser Gln 
                85                  90                  95      


Thr Asp Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala His Ala 
                165                 170                 175     


Ala Glu Gln Gln Arg Ala Tyr Leu Glu Gly Arg Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Thr Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210>  136
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Ala Val Met Ala Pro Arg Thr Leu Val Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Ser Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Glu Glu Thr Gly Lys Val Lys Ala His Ser Gln 
                85                  90                  95      


Thr Asp Arg Glu Asn Leu Arg Ile Ala Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Met Met Phe Gly Cys Asp Val Gly 
        115                 120                 125             


Ser Asp Gly Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala His Val 
                165                 170                 175     


Ala Glu Gln Gln Arg Ala Tyr Leu Glu Gly Thr Cys Val Asp Gly Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Asn Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210>  137
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Leu Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Thr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Asn Thr Arg Asn Val Lys Ala His Ser Gln 
                85                  90                  95      


Ile Asp Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Ile Gln Met Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Ser Asp Gly Arg Phe Leu Arg Gly Tyr Gln Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Ala Val Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ser Val Val 
            260                 265                 270         


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Phe Gly Ala 
305                 310                 315                 320 


Val Phe Ala Gly Ala Val Val Ala Ala Val Arg Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Met Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210>  138
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Leu Val Met Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Tyr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Asn Thr Gln Ile Tyr Lys Ala Gln Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Ser Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly His Asp Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Asp Lys Leu Glu Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  139
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  139

Met Arg Val Met Ala Pro Arg Ala Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Cys Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Asp Thr Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Gly Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Asn Tyr Lys Arg Gln Ala Gln 
                85                  90                  95      


Ala Asp Arg Val Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Leu Gln Arg Met Tyr Gly Cys Asp Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asp Gln Ser Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Leu Glu Ala Ala Arg Ala 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Leu Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Met Gln His Glu 
        275                 280                 285             


Gly Leu Gln Glu Pro Leu Thr Leu Ser Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Ala Val Leu Val Val 
305                 310                 315                 320 


Leu Ala Val Leu Gly Ala Val Val Thr Ala Met Met Cys Arg Arg Lys 
                325                 330                 335     


Ser Ser Gly Gly Lys Gly Gly Ser Cys Ser Gln Ala Ala Cys Ser Asn 
            340                 345                 350         


Ser Ala Gln Gly Ser Asp Glu Ser Leu Ile Thr Cys Lys 
        355                 360                 365 


<210>  140
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  140

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Lys Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gln Glu Thr 
    50                  55                  60                  


Arg Asn Met Lys Ala His Ser Gln Thr Asp Arg Ala Asn Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln 
                85                  90                  95      


Ile Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys 
    130                 135                 140                 


Arg Lys Trp Glu Ala Val His Ala Ala Glu Gln Arg Arg Val Tyr Leu 
145                 150                 155                 160 


Glu Gly Arg Cys Val Asp Gly Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu 
        275 


<210>  141
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  141

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Gly Ser His Ser 
    50                  55                  60                  


Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro 
65                  70                  75                  80  


Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe 
                85                  90                  95      


Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile 
            100                 105                 110         


Glu Gln Glu Gly Pro Glu Tyr Trp Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Arg Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Asp Lys Leu Glu Arg Ala Asp Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu 
        275 


<210>  142
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  142

Cys Ser His Ser Met Arg Tyr Phe Asp Thr Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Asn Tyr Lys Arg Gln Ala Gln Ala Asp Arg Val Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Leu Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Leu Glu Ala Ala Arg Ala Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala Glu Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Leu Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Met Gln His Glu Gly Leu Gln Glu Pro Leu Thr Leu 
            260                 265                 270         


Ser Trp Glu Pro 
        275     


<210>  143
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  143

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr 
    50                  55                  60                  


Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys 
    130                 135                 140                 


His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  144
<211>  273
<212>  PRT
<213>  Mus musculus

<400>  144

Gly Pro His Ser Leu Arg Tyr Phe Val Thr Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Leu Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Asp Asn Pro Arg Phe Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Met Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu Gln Thr 
    50                  55                  60                  


Gln Arg Ala Lys Ser Asp Glu Gln Trp Phe Arg Val Ser Leu Arg Thr 
65                  70                  75                  80  


Ala Gln Arg Tyr Tyr Asn Gln Ser Lys Gly Gly Ser His Thr Phe Gln 
                85                  90                  95      


Arg Met Phe Gly Cys Asp Val Gly Ser Asp Trp Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Gln Gln Phe Ala Tyr Asp Gly Arg Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Lys Thr Trp Thr Ala Ala Asp Thr Ala Ala Leu Ile Thr Arg 
    130                 135                 140                 


Arg Lys Trp Glu Gln Ala Gly Asp Ala Glu Tyr Tyr Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Leu Gly Asn 
                165                 170                 175     


Glu Thr Leu Leu Arg Thr Asp Ser Pro Lys Ala His Val Thr Tyr His 
            180                 185                 190         


Pro Arg Ser Gln Val Asp Val Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Asp Leu 
    210                 215                 220                 


Thr Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Lys Trp Ala Ala Val Val Val Pro Leu Gly Lys Glu Gln Asn Tyr 
                245                 250                 255     


Thr Cys His Val His His Lys Gly Leu Pro Glu Pro Leu Thr Leu Arg 
            260                 265                 270         


Trp 
    


<210>  145
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  145

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr 
    50                  55                  60                  


Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Ala Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys 
    130                 135                 140                 


His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu 
        275 


<210>  146
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  146

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr 
    50                  55                  60                  


Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala Gln Thr Thr Lys 
    130                 135                 140                 


His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu 
        275 


<210>  147
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  147

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr 
    50                  55                  60                  


Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Ala Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Lys Asp Tyr Ile Ala Leu Lys Glu Asp 
        115                 120                 125             


Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys His 
    130                 135                 140                 


Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His Ala 
            180                 185                 190         


Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe Tyr 
        195                 200                 205             


Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr 
    210                 215                 220                 


Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp Gly Thr Phe 
225                 230                 235                 240 


Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg Tyr 
                245                 250                 255     


Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg 
            260                 265                 270         


Trp Glu Pro 
        275 


<210>  148
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  148

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gln Glu Thr 
    50                  55                  60                  


Arg Asn Val Lys Ala Gln Ser Gln Thr Asp Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln 
                85                  90                  95      


Ile Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala His Ala Ala Glu Gln Gln Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu 
        275 


<210>  149
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  149

Gly Ser His Ser Met Arg Tyr Phe Ser Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Glu Glu Thr 
    50                  55                  60                  


Gly Lys Val Lys Ala His Ser Gln Thr Asp Arg Glu Asn Leu Arg Ile 
65                  70                  75                  80  


Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Met Met Phe Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala His Val Ala Glu Gln Gln Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Asp Gly Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro Ser Ser Gln Pro Thr Val Pro Ile Val Gly Ile Ile 
        275                 280                 285             


Ala Gly Leu Val Leu Leu Gly Ala Val Ile Thr Gly Ala Val Val Ala 
    290                 295                 300                 


Ala Val Met Trp Arg Arg Asn Ser Ser Asp Arg Lys Gly Gly Ser Tyr 
305                 310                 315                 320 


Ser Gln Ala Ala Ser Ser Asp Ser Ala Gln Gly Ser Asp Val Ser Leu 
                325                 330                 335     


Thr Ala Cys Lys Val 
            340     


<210>  150
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  150

Gly Ser His Ser Met Arg Tyr Phe Thr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Arg Asn Val Lys Ala His Ser Gln Ile Asp Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Ile Gln 
                85                  90                  95      


Met Met Tyr Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Gln Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ser Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro Ser Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Ile 
        275                 280                 285             


Ala Gly Leu Val Leu Phe Gly Ala Val Phe Ala Gly Ala Val Val Ala 
    290                 295                 300                 


Ala Val Arg Trp Arg Arg Lys Ser Ser Asp Arg Lys Gly Gly Ser Tyr 
305                 310                 315                 320 


Ser Gln Ala Ala Ser Ser Asp Ser Ala Gln Gly Ser Asp Met Ser Leu 
                325                 330                 335     


Thr Ala Cys Lys Val 
            340     


<210>  151
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  151

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  152
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  153
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  153

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Pro Glu Asn Gly Lys Pro Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Lys Met Gly Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Asn Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gly Pro Arg Thr 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  154
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  154

Met Ala Arg Phe Val Ala Leu Val Leu Leu Gly Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Asp Ala Ile Gln Arg Pro Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Pro Glu Asp Gly Lys Pro Asn Tyr Leu Asn Cys Tyr Val Tyr 
        35                  40                  45              


Gly Phe His Pro Pro Gln Ile Glu Ile Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Lys Ile Lys Ser Glu Gln Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser 
65                  70                  75                  80  


Phe Tyr Leu Leu Ser His Ala Glu Phe Thr Pro Asn Ser Lys Asp Gln 
                85                  90                  95      


Tyr Ser Cys Arg Val Lys His Val Thr Leu Glu Gln Pro Arg Ile Val 
            100                 105                 110         


Lys Trp Asp Arg Asp Leu 
        115             


<210>  155
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  155

Met Ala Arg Ser Val Thr Leu Val Phe Leu Val Leu Val Ser Leu Thr 
1               5                   10                  15      


Gly Leu Tyr Ala Ile Gln Lys Thr Pro Gln Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Pro Glu Asn Gly Lys Pro Asn Ile Leu Asn Cys Tyr Val Thr 
        35                  40                  45              


Gln Phe His Pro Pro His Ile Glu Ile Gln Met Leu Lys Asn Gly Lys 
    50                  55                  60                  


Lys Ile Pro Lys Val Glu Met Ser Asp Met Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Ile Leu Ala His Thr Glu Phe Thr Pro Thr Glu Thr Asp 
                85                  90                  95      


Thr Tyr Ala Cys Arg Val Lys His Ala Ser Met Ala Glu Pro Lys Thr 
            100                 105                 110         


Val Tyr Trp Asp Arg Asp Met 
        115                 


<210>  156
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MHC Class I heavy chain sequence with variable regions


<220>
<221>  Unsure
<222>  (79)..(79)
<223>  Xaa is (i) any amino acid or (ii)  any amino acid except proline 
       or glycine

<220>
<221>  Unsure
<222>  (80)..(80)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (81)..(81)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (82)..(82)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (83)..(83)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (85)..(85)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (86)..(86)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (87)..(87)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (88)..(88)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (89)..(89)
<223>  Xaa is (i) any amino acid or (ii) or ii)  any amino acid except 
       proline or glycine

<220>
<221>  Unsure
<222>  (134)..(134)
<223>  Xaa is (i) any amino acid or (ii) or ii)  any amino acid except 
       proline or glycine

<220>
<221>  Unsure
<222>  (135)..(135)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (136)..(136)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (137)..(137)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (138)..(138)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (138)..(138)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (140)..(140)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (141)..(141)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (142)..(142)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (143)..(143)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (144)..(144)
<223>  Xaa is (i) any amino acid or (ii) any amino acid except proline 
       or glycine

<400>  156

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr 
    50                  55                  60                  


Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Ala Gly Ser His Thr Val Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  157
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  157

Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Cys His Pro Ala Glu 
1               5                   10                  15      


Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro 
            20                  25                  30          


Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys 
        35                  40                  45              


Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu 
    50                  55                  60                  


Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys 
65                  70                  75                  80  


Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp 
                85                  90                  95      


Arg Asp Met 
            


<210>  158
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MHC Class 1 heavy chain sequence with variable regions


<220>
<221>  Unsure
<222>  (79)..(79)
<223>  Xaa is (i) any amino acid or (ii) any amino acid except proline 
       or glycine

<220>
<221>  Unsure
<222>  (79)..(79)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (80)..(80)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (81)..(81)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (82)..(82)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (83)..(83)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (85)..(85)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (86)..(86)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (87)..(87)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (88)..(88)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (89)..(89)
<223>  Xaa is (i) any amino acid or (ii) any amino acid except proline 
       or glycine

<220>
<221>  Unsure
<222>  (134)..(134)
<223>  Xaa  is (i) any amino acid or (ii) any amino acid except proline 
       or glycine

<220>
<221>  Unsure
<222>  (135)..(135)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (136)..(136)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (137)..(137)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (138)..(138)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (140)..(140)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (141)..(141)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (142)..(142)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (143)..(143)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (144)..(144)
<223>  Xaa is (i) any amino acid or (ii) any amino acid except proline 
       or glycine

<220>
<221>  Unsure
<222>  (231)..(231)
<223>  Xaa  is (i) any amino acid or (ii) any amino acid except proline 
       or glycine

<220>
<221>  Unsure
<222>  (232)..(232)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (233)..(233)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (234)..(234)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (235)..(235)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (237)..(237)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (238)..(238)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (239)..(239)
<223>  Xaa is present or absent, and when present is (i) any amino acid 
       or (ii) any amino acid except proline or glycine

<220>
<221>  Unsure
<222>  (240)..(240)
<223>  Xaa is (i) any amino acid or (ii) any amino acid except proline 
       or glycine

<220>
<221>  misc_feature
<222>  (241)..(241)
<223>  Xaa can be any naturally occurring amino acid

<400>  158

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr 
    50                  55                  60                  


Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Ala Gly Ser His Thr Val Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  159
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Val-Pro-Gly-X-Gly pentapeptide


<220>
<221>  unsure
<222>  (4)..(4)
<223>  Xaa is any amino acid other than proline

<400>  159

Val Pro Gly Xaa Gly 
1               5   


<210>  160
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE COSTRUCT

<400>  160

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Gly Gly Gly Gly Ser Leu Cys Thr Pro Ser Arg Gly 
            20                  25                  30          


Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Cys 
        35                  40                  45              


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
    50                  55                  60                  


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
65                  70                  75                  80  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
                85                  90                  95      


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
            100                 105                 110         


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
        115                 120                 125             


Val Lys Trp Asp Arg Asp Met 
    130                 135 


<210>  161
<211>  833
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE CONSTRUCT

<400>  161

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr 
                165                 170                 175     


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu 
            180                 185                 190         


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
        195                 200                 205             


Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr 
    210                 215                 220                 


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
225                 230                 235                 240 


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
                245                 250                 255     


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
            260                 265                 270         


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
        275                 280                 285             


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
    290                 295                 300                 


Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr 
                325                 330                 335     


Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly 
            340                 345                 350         


Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser 
        355                 360                 365             


Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu 
    370                 375                 380                 


Tyr Trp Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His 
385                 390                 395                 400 


Arg Val Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala 
                405                 410                 415     


Gly Ser His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp 
            420                 425                 430         


Trp Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp 
        435                 440                 445             


Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met 
    450                 455                 460                 


Cys Ala Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu 
465                 470                 475                 480 


Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg 
                485                 490                 495     


Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys 
            500                 505                 510         


Thr His Met Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg 
        515                 520                 525             


Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln 
    530                 535                 540                 


Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg 
545                 550                 555                 560 


Pro Cys Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro 
                565                 570                 575     


Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu 
            580                 585                 590         


Pro Lys Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys 
        595                 600                 605             


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    610                 615                 620                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
625                 630                 635                 640 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                645                 650                 655     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            660                 665                 670         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        675                 680                 685             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    690                 695                 700                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
705                 710                 715                 720 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                725                 730                 735     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            740                 745                 750         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        755                 760                 765             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    770                 775                 780                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
785                 790                 795                 800 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                805                 810                 815     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            820                 825                 830         


Lys 
    


<210>  162
<211>  527
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE CONSTRUCT

<400>  162

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val 
            20                  25                  30          


Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val 
        35                  40                  45              


Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg 
    50                  55                  60                  


Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp 
65                  70                  75                  80  


Asp Gln Glu Thr Arg Asn Val Lys Ala Gln Ser Gln Thr Asp Arg Val 
                85                  90                  95      


Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Asp Gly Ser 
            100                 105                 110         


His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg 
        115                 120                 125             


Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile 
    130                 135                 140                 


Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala 
145                 150                 155                 160 


Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala His Ala Ala Glu Gln Gln 
                165                 170                 175     


Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu 
            180                 185                 190         


Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His 
        195                 200                 205             


Met Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp 
    210                 215                 220                 


Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp 
225                 230                 235                 240 


Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys 
                245                 250                 255     


Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly 
            260                 265                 270         


Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys 
        275                 280                 285             


Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His 
    290                 295                 300                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
305                 310                 315                 320 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                325                 330                 335     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            340                 345                 350         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        355                 360                 365             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    370                 375                 380                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
385                 390                 395                 400 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                405                 410                 415     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            420                 425                 430         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        435                 440                 445             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    450                 455                 460                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
465                 470                 475                 480 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                485                 490                 495     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            500                 505                 510         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        515                 520                 525         


<210>  163
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE CONSTRUCT

<400>  163

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gln Glu Thr 
    50                  55                  60                  


Arg Asn Val Lys Ala Gln Ser Gln Thr Asp Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Cys Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln 
                85                  90                  95      


Ile Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala Gln Ile Thr Lys 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala His Ala Ala Glu Gln Gln Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu 
        275 


<210>  164
<211>  833
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE CONSTRUCT

<400>  164

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr 
                165                 170                 175     


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu 
            180                 185                 190         


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
        195                 200                 205             


Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr 
    210                 215                 220                 


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
225                 230                 235                 240 


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
                245                 250                 255     


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
            260                 265                 270         


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
        275                 280                 285             


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
    290                 295                 300                 


Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Tyr Thr 
                325                 330                 335     


Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly 
            340                 345                 350         


Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser 
        355                 360                 365             


Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu 
    370                 375                 380                 


Tyr Trp Asp Gln Glu Thr Arg Asn Val Lys Ala Gln Ser Gln Thr Asp 
385                 390                 395                 400 


Arg Val Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Asp 
                405                 410                 415     


Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly Pro Asp 
            420                 425                 430         


Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp 
        435                 440                 445             


Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met 
    450                 455                 460                 


Cys Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala His Ala Ala Glu 
465                 470                 475                 480 


Gln Gln Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg 
                485                 490                 495     


Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys 
            500                 505                 510         


Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg 
        515                 520                 525             


Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln 
    530                 535                 540                 


Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg 
545                 550                 555                 560 


Pro Cys Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro 
                565                 570                 575     


Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu 
            580                 585                 590         


Pro Lys Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys 
        595                 600                 605             


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    610                 615                 620                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
625                 630                 635                 640 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                645                 650                 655     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            660                 665                 670         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        675                 680                 685             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    690                 695                 700                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
705                 710                 715                 720 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                725                 730                 735     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            740                 745                 750         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        755                 760                 765             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    770                 775                 780                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
785                 790                 795                 800 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                805                 810                 815     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            820                 825                 830         


Lys 
    


<210>  165
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PROTEIN CONSTRUCT

<400>  165

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val 
            20                  25                  30          


Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val 
        35                  40                  45              


Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg 
    50                  55                  60                  


Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp 
65                  70                  75                  80  


Asp Gln Glu Thr Arg Asn Val Lys Ala Gln Ser Gln Thr Asp Arg Val 
                85                  90                  95      


Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Asp Gly Ser 
            100                 105                 110         


His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg 
        115                 120                 125             


Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile 
    130                 135                 140                 


Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala 
145                 150                 155                 160 


Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala His Ala Ala Glu Gln Gln 
                165                 170                 175     


Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu 
            180                 185                 190         


Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His 
        195                 200                 205             


Met Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp 
    210                 215                 220                 


Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp 
225                 230                 235                 240 


Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys 
                245                 250                 255     


Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly 
            260                 265                 270         


Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys 
        275                 280                 285             


Pro Leu Thr Leu Arg Trp Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                325                 330                 335     


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            340                 345                 350         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        355                 360                 365             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    370                 375                 380                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
385                 390                 395                 400 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                405                 410                 415     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            420                 425                 430         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        435                 440                 445             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    450                 455                 460                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
465                 470                 475                 480 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                485                 490                 495     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            500                 505                 510         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        515                 520                 525             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    530                 535                 540                 


Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550         


<210>  166
<211>  858
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE CONSTRUCT

<400>  166

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr 
                165                 170                 175     


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu 
            180                 185                 190         


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
        195                 200                 205             


Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr 
    210                 215                 220                 


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
225                 230                 235                 240 


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
                245                 250                 255     


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
            260                 265                 270         


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
        275                 280                 285             


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
    290                 295                 300                 


Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Tyr Thr 
                325                 330                 335     


Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly 
            340                 345                 350         


Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser 
        355                 360                 365             


Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu 
    370                 375                 380                 


Tyr Trp Asp Gln Glu Thr Arg Asn Val Lys Ala Gln Ser Gln Thr Asp 
385                 390                 395                 400 


Arg Val Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Asp 
                405                 410                 415     


Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly Pro Asp 
            420                 425                 430         


Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp 
        435                 440                 445             


Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met 
    450                 455                 460                 


Cys Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala His Ala Ala Glu 
465                 470                 475                 480 


Gln Gln Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg 
                485                 490                 495     


Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys 
            500                 505                 510         


Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg 
        515                 520                 525             


Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln 
    530                 535                 540                 


Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg 
545                 550                 555                 560 


Pro Cys Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro 
                565                 570                 575     


Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu 
            580                 585                 590         


Pro Lys Pro Leu Thr Leu Arg Trp Glu Gly Gly Gly Gly Ser Gly Gly 
        595                 600                 605             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
625                 630                 635                 640 


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                645                 650                 655     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            660                 665                 670         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        675                 680                 685             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    690                 695                 700                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
705                 710                 715                 720 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                725                 730                 735     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            740                 745                 750         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        755                 760                 765             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    770                 775                 780                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
785                 790                 795                 800 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                805                 810                 815     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            820                 825                 830         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        835                 840                 845             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    850                 855             


<210>  167
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  167

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala 
            20  


<210>  168
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  169
<211>  833
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PROTEIN CONSTRUCT

<400>  169

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr 
                165                 170                 175     


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu 
            180                 185                 190         


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
        195                 200                 205             


Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr 
    210                 215                 220                 


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
225                 230                 235                 240 


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
                245                 250                 255     


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
            260                 265                 270         


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
        275                 280                 285             


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
    290                 295                 300                 


Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Tyr Thr 
                325                 330                 335     


Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly 
            340                 345                 350         


Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser 
        355                 360                 365             


Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu 
    370                 375                 380                 


Tyr Trp Asp Gln Glu Thr Arg Asn Val Lys Ala Gln Ser Gln Thr Asp 
385                 390                 395                 400 


Arg Val Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Asp 
                405                 410                 415     


Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly Pro Asp 
            420                 425                 430         


Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp 
        435                 440                 445             


Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Cys Ala Asp Met 
    450                 455                 460                 


Cys Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala His Ala Ala Glu 
465                 470                 475                 480 


Gln Gln Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg 
                485                 490                 495     


Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys 
            500                 505                 510         


Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg 
        515                 520                 525             


Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln 
    530                 535                 540                 


Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg 
545                 550                 555                 560 


Pro Cys Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro 
                565                 570                 575     


Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu 
            580                 585                 590         


Pro Lys Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys 
        595                 600                 605             


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    610                 615                 620                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
625                 630                 635                 640 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                645                 650                 655     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            660                 665                 670         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        675                 680                 685             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    690                 695                 700                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
705                 710                 715                 720 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                725                 730                 735     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            740                 745                 750         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        755                 760                 765             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    770                 775                 780                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
785                 790                 795                 800 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                805                 810                 815     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            820                 825                 830         


Lys 
    


<210>  170
<211>  9
<212>  PRT
<213>  cytomegalovirus

<400>  170

Asn Leu Val Pro Met Val Ala Thr Val 
1               5                   


