               SEQUENCE LISTING

<110> Combined Therapeutics

<120> COMPOSITIONS AND PROCESSES FOR TARGETED DELIVERY, EXPRESSION AND MODULATION OF CODING RIBONUCLEIC ACIDS IN TISSUE

<130> P44379WO

<150> US62632056
<151> 2018-02-19
<150> GB1714430.4
<151> 2017-09-07

<160> 5

<170> BiSSAP 1.3.6

<210> 1
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> single miR122 binding site

<400> 1
aacgccauua ucacacuaaa ua                                             22


<210> 2
<211> 50
<212> RNA
<213> Artificial Sequence


<220> 
<223> 2x miR-122 binding sites with linker

<400> 2
aacgccauua ucacacuaaa uauuuaaaaa cgccauuauc acacuaaaua                50


<210> 3
<211> 761
<212> RNA
<213> Artificial Sequence


<220> 
<223> mCherry sequence with 2x miR-122 binding sequence and linker

<400> 3
auggugagca agggcgagga ggauaacaug gccaucauca aggaguucau gcgcuucaag      60

gugcacaugg agggcuccgu gaacggccac gaguucgaga ucgagggcga gggcgagggc     120

cgccccuacg agggcaccca gaccgccaag cugaagguga ccaagggugg cccccugccc     180

uucgccuggg acauccuguc cccucaguuc auguacggcu ccaaggccua cgugaagcac     240

cccgccgaca uccccgacua cuugaagcug uccuuccccg agggcuucaa gugggagcgc     300

gugaugaacu ucgaggacgg cggcguggug accgugaccc aggacuccuc ccugcaggac     360

ggcgaguuca ucuacaaggu gaagcugcgc ggcaccaacu uccccuccga cggccccgua     420

augcagaaga agaccauggg cugggaggcc uccuccgagc ggauguaccc cgaggacggc     480

gcccugaagg gcgagaucaa gcagaggcug aagcugaagg acggcggcca cuacgacgcu     540

gaggucaaga ccaccuacaa ggccaagaag cccgugcagc ugcccggcgc cuacaacguc     600

aacaucaagu uggacaucac cucccacaac gaggacuaca ccaucgugga acaguacgaa     660

cgcgccgagg gccgccacuc caccggcggc auggacgagc uguacaagua aaacgccauu     720

aucacacuaa auauuuaaaa acgccauuau cacacuaaau a                         761


<210> 4
<211> 1496
<212> RNA
<213> Artificial Sequence


<220> 
<223> US3 with 2x miR-122 binding sites and linker

<400> 4
auggccuguc guaaguuuug ucgcguuuac gggggacagg gcaggaggaa ggaggaggcc      60

gucccgccgg agacaaagcc gucccgggug uuuccucaug gccccuuuua uaccccagcc     120

gaggacgcgu gccuggacuc cccgcccccg gagaccccca aaccuuccca caccacacca     180

cccggcgaug ccgagcgccu gugucaucug caggagaucc uggcccagau guacggaaac     240

caggacuacc ccauagagga cgaccccagc gcggaugccg cggacgaugu cgacgaggac     300

gccccggacg acguggccua uccggaggaa uacgcagagg agcuuuuucu gcccggggac     360

gcgcccgguc cccuuaucgg ggccaacgac cacaucccuc ccccgugugg cgcaucuccc     420

cccgguauac gacgacgcag ccgggaugag auuggggcca cgggauuuac cgcggaagaa     480

cuggacgcca uggacaggga ggcggcucga gccaucagcc gcggcggcaa gccccccucg     540

accauggcca agcuggugac uggcaugggc uuuacgaucc acggagcgcu caccccagga     600

ucggaggggu gugucuuuga cagcagccac ccagauuacc cccaacgggu aaucgugaag     660

gcgggguggu acacgagcac gagccacgag gcgcgacugc ugaggcgacu ggaccacccc     720

gcgauccugc cccuccugga ccugcauguc gucuccgggg ucacgugucu gguccucccc     780

aaguaccagg ccgaccugua uaccuaucug aguaggcgcc ugaacccgcu gggacgcccg     840

cagaucgcag cggucucccg gcagcuccua agcgccguug acuacauuca ccgccagggc     900

auuauccacc gcgacauuaa gaccgaaaau auuuuuauua acacccccga ggacauuugc     960

cugggggacu uuggugccgc gugcuucgug caggguuccc gaucaagccc cuuccccuac    1020

ggaaucgccg gaaccaucga caccaacgcc cccgaggucc ugaccgggga uccguauacc    1080

accaccgucg acauuuggag cgccggucug gugaucuucg agacugccgu ccacaacgcg    1140

uccuuguucu cggccccccg cggccccaaa aggggcccgu gcgacaguca gaucacccgc    1200

aucauccgac aggcccaggu ccacguugac gaguuuuccc cgcauccaga aucgcgccuc    1260

accucgcgcu accgcucccg cgcggccggg aacaaucgcc cgccguacac ccgaccggcc    1320

uggacccgcu acuacaagau ggacauagac gucgaauauc ugguuugcaa agcccucacc    1380

uucgacggcg cgcuucgccc cagcgccgca gagcugcuuu guuugccgcu guuucaacag    1440

aaaugaaacg ccauuaucac acuaaauauu uaaaaacgcc auuaucacac uaaaua        1496


<210> 5
<211> 3466
<212> RNA
<213> Artificial Sequence


<220> 
<223> ICP6 with 2x miRNA-122 binding site sequences

<400> 5
augauggcca gccgcccagc cgcauccucu cccgucgaag cgcgggcccc gguuggggga       60

caggaggccg gcggccccag cgcagccacc cagggggagg ccgccggggc cccucucgcc      120

cacggccacc acguguacug ccagcgaguc aauggcguga uggugcuuuc cgacaagacg      180

cccggguccg cguccuaccg caucagcgau agcaacuuug uccaaugugg uuccaacugc      240

accaugauua ucgacggaga cguggugcgc gggcgccccc aggacccggg ggccgcggca      300

ucccccgcuc ccuucguugc ggugacaaac aucggagccg gcagcgacgg cgggaccgcc      360

gucguugcau ucgggggaac cccacgucgc ucggcgggga cgucuaccgg uacccagacg      420

gccgacgucc cagccgaggc ccuugggggc cccccuccuc cuccccgcuu cacccugggu      480

ggcggcuguu gcuccugucg cgacacacgg cgccgcucug cgguauucgg gggggagggg      540

gaucccgucg gccccgcgga guucgucucg gacgaccggu cguccgauuc cgacucggau      600

gacucggagg acaccgacuc ggagacgcug ucacacgccu ccucggacgu guccggcggg      660

gccacguacg acgacgcccu ugacuccgau ucgucaucgg augacucccu gcagauagau      720

ggccccgugu gucgcccgug gagcaaugac accgcgcccc uggauguuug ccccgggacc      780

cccggcccgg gcgccgacgc cggugguccc ucagcgguag acccacacgc gccgacgaca      840

ggggccggcg cuggucuugc ggccgauccc gccguggccc gggacgacgc ggaggggcuu      900

ucggaccccc ggccacgucu gggaacgggc acggccuacc ccgucccccu ggaacucacg      960

cccgagaacg cggaggccgu ggcgcgcuuu cugggagaug ccgugaaccg cgaacccgcg     1020

cucaugcugg aguacuuuug ccggugcgcc cgcgaggaaa ccaagcgugu cccccccagg     1080

acauucugca gccccccucg ccucacggag gacgacuuug ggcuucucaa cuacgcgcuc     1140

guggagaugc agcgccugug ucuggacguu ccuccggucc cgccgaacgc auacaugccc     1200

uauuaucuca gggaguaugu gacgcggcug gucaacgggu ucaagccgcu ggugagccgg     1260

uccguucgcc uuuaccgcau ccuggggguu cuggugcacc ugcggauccg gacccgggag     1320

gccuccuuug aggaguggcu gcgauccaag gaaguggccc uggacuuugg ccugacggaa     1380

aggcuucgcg agcacgaagc ccagcuggug auccuggccc aggcucugga ccauuacgac     1440

ugucugaucc acagcacacc gcacacgcug gucgagcggg ggcugcaauc ggcccugaag     1500

uaugaggagu uuuaccuaaa gcgcuuuggc gggcacuaca uggaguccgu cuuccagaug     1560

uacacccgca ucgccggcuu uuuggccugc cgggccacgc gcggcaugcg ccacaucgcc     1620

cuggggcgag aggggucgug gugggaaaug uucaaguucu uuuuccaccg ccucuacgac     1680

caccagaucg uaccgucgac ccccgccaug cugaaccugg ggacccgcaa cuacuacacc     1740

uccagcugcu accugguaaa cccccaggcc accacaaaca aggcgacccu gcgggccauc     1800

accagcaacg ucagugccau ccucgcccgc aacgggggca ucgggcuaug cgugcaggcg     1860

uuuaacgacu ccggccccgg gaccgccagc gucaugcccg cccucaaggu ccucgacucg     1920

cugguggcgg cgcacaacaa agagagcgcg cguccgaccg gcgcgugcgu guaccuggag     1980

ccguggcaca ccgacgugcg ggccgugcuc cggaugaagg ggguccucgc cggcgaagag     2040

gcccagcgcu gcgacaauau cuucagcgcc cucuggaugc cagaccuguu uuucaagcgc     2100

cugauucgcc accuggacgg cgagaagaac gucacaugga cccuguucga ccgggacacc     2160

agcaugucgc ucgccgacuu ucacggggag gaguucgaga agcucuacca gcaccucgag     2220

gucauggggu ucggcgagca gauacccauc caggagcugg ccuauggcau ugugcgcagu     2280

gcggccacga ccgggagccc cuucgucaug uucaaagacg cggugaaccg ccacuacauc     2340

uacgacaccc agggggcggc caucgccggc uccaaccucu gcaccgagau cguccauccg     2400

gccuccaagc gauccagugg ggucugcaau cugggaagcg ugaaucuggc ccgaugcguc     2460

uccaggcaga cguuugacuu ugggcggcuc cgcgacgccg ugcaggcgug cgugcugaug     2520

gugaacauca ugaucgacag cacgcuacaa cccacgcccc agugcacccg cggcaacgac     2580

aaccugcggu ccaugggaau cggcaugcag ggccugcaca cggccugccu gaagcugggg     2640

cuggaucugg agucugccga auuucaggac cugaacaaac acaucgccga ggugaugcug     2700

cugucggcga ugaagaccag caacgcgcug ugcguucgcg gggcccgucc cuucaaccac     2760

uuuaagcgca gcauguaucg cgccggccgc uuucacuggg agcgcuuucc ggacgcccgg     2820

ccgcgguacg agggcgagug ggagaugcua cgccagagca ugaugaaaca cggccugcgc     2880

aacagccagu uugucgcgcu gaugcccacc gccgccucgg cgcagaucuc ggacgucagc     2940

gagggcuuug ccccccuguu caccaaccug uuuagcaagg ugacccggga cggcgagacg     3000

cugcgcccca acacgcuccu gcuaaaggaa cuggaacgca cguuuagcgg gaagcgccuc     3060

cuggagguga uggacaguuc gacgccaagc agugguccgu ggcgcaggcg cucccgugcc     3120

uggagcccac ccacccccuc cggcgauuca agaccgcguu ugacuacgac cagaaguugc     3180

ugaucgaccu gugugcggac cgcgcccccu acgucgacca uagccaaucc augacccugu     3240

augucacgga gaaggcggac gggacccucc cagccuccac ccugguccgc cuucuggucc     3300

acgcauauaa gcgcggacua aaaacaggga uguacuacug caagguucgc aaggcgacca     3360

acagcggggu cuuuggcggc gacgacaaca uugucugcac gagcugcgcg cuguagaacg     3420

ccauuaucac acuaaauauu uaaaaacgcc auuaucacac uaaaua                    3466


