                               SEQUENCE LISTING

<110> AZITRA INC
 
<120> METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY SKIN DISEASE 
      WITH RECOMBINANT MICROORGANISMS

<130> 129062-00120

<140> PCT/US2018/049477
<141> 2018-09-05

<150> 62/685,687
<151> 2018-06-15

<150> 62/554,271
<151> 2017-09-05

<160> 52    

<170> PatentIn version 3.5

<210> 1
<211> 4061
<212> PRT
<213> Homo sapiens

<400> 1
Met Ser Thr Leu Leu Glu Asn Ile Phe Ala Ile Ile Asn Leu Phe Lys 
1               5                   10                  15      


Gln Tyr Ser Lys Lys Asp Lys Asn Thr Asp Thr Leu Ser Lys Lys Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Lys Glu Phe Arg Gln Ile Leu Lys Asn Pro 
        35                  40                  45              


Asp Asp Pro Asp Met Val Asp Val Phe Met Asp His Leu Asp Ile Asp 
    50                  55                  60                  


His Asn Lys Lys Ile Asp Phe Thr Glu Phe Leu Leu Met Val Phe Lys 
65                  70                  75                  80  


Leu Ala Gln Ala Tyr Tyr Glu Ser Thr Arg Lys Glu Asn Leu Pro Ile 
                85                  90                  95      


Ser Gly His Lys His Arg Lys His Ser His His Asp Lys His Glu Asp 
            100                 105                 110         


Asn Lys Gln Glu Glu Asn Lys Glu Asn Arg Lys Arg Pro Ser Ser Leu 
        115                 120                 125             


Glu Arg Arg Asn Asn Arg Lys Gly Asn Lys Gly Arg Ser Lys Ser Pro 
    130                 135                 140                 


Arg Glu Thr Gly Gly Lys Arg His Glu Ser Ser Ser Glu Lys Lys Glu 
145                 150                 155                 160 


Arg Lys Gly Tyr Ser Pro Thr His Arg Glu Glu Glu Tyr Gly Lys Asn 
                165                 170                 175     


His His Asn Ser Ser Lys Lys Glu Lys Asn Lys Thr Glu Asn Thr Arg 
            180                 185                 190         


Leu Gly Asp Asn Arg Lys Arg Leu Ser Glu Arg Leu Glu Glu Lys Glu 
        195                 200                 205             


Asp Asn Glu Glu Gly Val Tyr Asp Tyr Glu Asn Thr Gly Arg Met Thr 
    210                 215                 220                 


Gln Lys Trp Ile Gln Ser Gly His Ile Ala Thr Tyr Tyr Thr Ile Gln 
225                 230                 235                 240 


Asp Glu Ala Tyr Asp Thr Thr Asp Ser Leu Leu Glu Glu Asn Lys Ile 
                245                 250                 255     


Tyr Glu Arg Ser Arg Ser Ser Asp Gly Lys Ser Ser Ser Gln Val Asn 
            260                 265                 270         


Arg Ser Arg His Glu Asn Thr Ser Gln Val Pro Leu Gln Glu Ser Arg 
        275                 280                 285             


Thr Arg Lys Arg Arg Gly Ser Arg Val Ser Gln Asp Arg Asp Ser Glu 
    290                 295                 300                 


Gly His Ser Glu Asp Ser Glu Arg His Ser Gly Ser Ala Ser Arg Asn 
305                 310                 315                 320 


His His Gly Ser Ala Trp Glu Gln Ser Arg Asp Gly Ser Arg His Pro 
                325                 330                 335     


Arg Ser His Asp Glu Asp Arg Ala Ser His Gly His Ser Ala Asp Ser 
            340                 345                 350         


Ser Arg Gln Ser Gly Thr Arg His Ala Glu Thr Ser Ser Arg Gly Gln 
        355                 360                 365             


Thr Ala Ser Ser His Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg His 
    370                 375                 380                 


Gly Ser Gly His Gln Gln Ser Ala Asp Ser Ser Arg His Ser Ala Thr 
385                 390                 395                 400 


Gly Arg Gly Gln Ala Ser Ser Ala Val Ser Asp Arg Gly His Arg Gly 
                405                 410                 415     


Ser Ser Gly Ser Gln Ala Ser Asp Ser Glu Gly His Ser Glu Asn Ser 
            420                 425                 430         


Asp Thr Gln Ser Val Ser Gly His Gly Lys Ala Gly Leu Arg Gln Gln 
        435                 440                 445             


Ser His Gln Glu Ser Thr Arg Gly Arg Ser Gly Glu Arg Ser Gly Arg 
    450                 455                 460                 


Ser Gly Ser Ser Leu Tyr Gln Val Ser Thr His Glu Gln Pro Asp Ser 
465                 470                 475                 480 


Ala His Gly Arg Thr Gly Thr Ser Thr Gly Gly Arg Gln Gly Ser His 
                485                 490                 495     


His Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala Ser Gln Glu Gly 
            500                 505                 510         


Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg Gly Gly Arg Gln 
        515                 520                 525             


Gly Ser His His Glu Gln Ser Val Asn Arg Ser Gly His Ser Gly Ser 
    530                 535                 540                 


His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp Ala Ser His Gly 
545                 550                 555                 560 


Gln Ser Gly Ser Arg Ser Ala Ser Arg Gln Thr Arg Asn Glu Glu Gln 
                565                 570                 575     


Ser Gly Asp Gly Thr Arg His Ser Gly Ser Arg His His Glu Ala Ser 
            580                 585                 590         


Ser Gln Ala Asp Ser Ser Arg His Ser Gln Val Gly Gln Gly Gln Ser 
        595                 600                 605             


Ser Gly Pro Arg Thr Ser Arg Asn Gln Gly Ser Ser Val Ser Gln Asp 
    610                 615                 620                 


Ser Asp Ser Gln Gly His Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser 
625                 630                 635                 640 


Ala Ser Arg Asn His His Gly Ser Ala Gln Glu Gln Ser Arg Asp Gly 
                645                 650                 655     


Ser Arg His Pro Arg Ser His His Glu Asp Arg Ala Gly His Gly His 
            660                 665                 670         


Ser Ala Asp Ser Ser Arg Lys Ser Gly Thr Arg His Thr Gln Asn Ser 
        675                 680                 685             


Ser Ser Gly Gln Ala Ala Ser Ser His Glu Gln Ala Arg Ser Ser Ala 
    690                 695                 700                 


Gly Glu Arg His Gly Ser Arg His Gln Leu Gln Ser Ala Asp Ser Ser 
705                 710                 715                 720 


Arg His Ser Gly Thr Gly His Gly Gln Ala Ser Ser Ala Val Arg Asp 
                725                 730                 735     


Ser Gly His Arg Gly Ser Ser Gly Ser Gln Ala Thr Asp Ser Glu Gly 
            740                 745                 750         


His Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Gly His Gly Gln Ala 
        755                 760                 765             


Gly His His Gln Gln Ser His Gln Glu Ser Ala Arg Asp Arg Ser Gly 
    770                 775                 780                 


Glu Arg Ser Arg Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His 
785                 790                 795                 800 


Lys Gln Ser Glu Ser Ser His Gly Trp Thr Gly Pro Ser Thr Gly Val 
                805                 810                 815     


Arg Gln Gly Ser His His Glu Gln Ala Arg Asp Asn Ser Arg His Ser 
            820                 825                 830         


Ala Ser Gln Asp Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser 
        835                 840                 845             


Arg Arg Gly Arg Gln Gly Ser His His Glu Gln Ser Val Asp Arg Ser 
    850                 855                 860                 


Gly His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser 
865                 870                 875                 880 


Asp Ala Ser Arg Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Thr Thr 
                885                 890                 895     


Arg Asn Glu Glu Gln Ser Arg Asp Gly Ser Arg His Ser Gly Ser Arg 
            900                 905                 910         


His His Glu Ala Ser Ser His Ala Asp Ile Ser Arg His Ser Gln Ala 
        915                 920                 925             


Gly Gln Gly Gln Ser Glu Gly Ser Arg Thr Ser Arg Arg Gln Gly Ser 
    930                 935                 940                 


Ser Val Ser Gln Asp Ser Asp Ser Glu Gly His Ser Glu Asp Ser Glu 
945                 950                 955                 960 


Arg Trp Ser Gly Ser Ala Ser Arg Asn His Arg Gly Ser Ala Gln Glu 
                965                 970                 975     


Gln Ser Arg His Gly Ser Arg His Pro Arg Ser His His Glu Asp Arg 
            980                 985                 990         


Ala Gly His Gly His Ser Ala Asp  Ser Ser Arg Gln Ser  Gly Thr Pro 
        995                 1000                 1005             


His Ala  Glu Thr Ser Ser Gly  Gly Gln Ala Ala Ser  Ser His Glu 
    1010                 1015                 1020             


Gln Ala  Arg Ser Ser Pro Gly  Glu Arg His Gly Ser  Arg His Gln 
    1025                 1030                 1035             


Gln Ser  Ala Asp Ser Ser Arg  His Ser Gly Ile Pro  Arg Arg Gln 
    1040                 1045                 1050             


Ala Ser  Ser Ala Val Arg Asp  Ser Gly His Trp Gly  Ser Ser Gly 
    1055                 1060                 1065             


Ser Gln  Ala Ser Asp Ser Glu  Gly His Ser Glu Glu  Ser Asp Thr 
    1070                 1075                 1080             


Gln Ser  Val Ser Gly His Gly  Gln Asp Gly Pro His  Gln Gln Ser 
    1085                 1090                 1095             


His Gln  Glu Ser Ala Arg Asp  Trp Ser Gly Gly Arg  Ser Gly Arg 
    1100                 1105                 1110             


Ser Gly  Ser Phe Ile Tyr Gln  Val Ser Thr His Glu  Gln Ser Glu 
    1115                 1120                 1125             


Ser Ala  His Gly Arg Thr Arg  Thr Ser Thr Gly Arg  Arg Gln Gly 
    1130                 1135                 1140             


Ser His  His Glu Gln Ala Arg  Asp Ser Ser Arg His  Ser Ala Ser 
    1145                 1150                 1155             


Gln Glu  Gly Gln Asp Thr Ile  Arg Ala His Pro Gly  Ser Arg Arg 
    1160                 1165                 1170             


Gly Gly  Arg Gln Gly Ser His  His Glu Gln Ser Val  Asp Arg Ser 
    1175                 1180                 1185             


Gly His  Ser Gly Ser His His  Ser His Thr Thr Ser  Gln Gly Arg 
    1190                 1195                 1200             


Ser Asp  Ala Ser His Gly Gln  Ser Gly Ser Arg Ser  Ala Ser Arg 
    1205                 1210                 1215             


Gln Thr  Arg Lys Asp Lys Gln  Ser Gly Asp Gly Ser  Arg His Ser 
    1220                 1225                 1230             


Gly Ser  Arg His His Glu Ala  Ala Ser Trp Ala Asp  Ser Ser Arg 
    1235                 1240                 1245             


His Ser  Gln Val Gly Gln Glu  Gln Ser Ser Gly Ser  Arg Thr Ser 
    1250                 1255                 1260             


Arg His  Gln Gly Ser Ser Val  Ser Gln Asp Ser Asp  Ser Glu Arg 
    1265                 1270                 1275             


His Ser  Asp Asp Ser Glu Arg  Leu Ser Gly Ser Ala  Ser Arg Asn 
    1280                 1285                 1290             


His His  Gly Ser Ser Arg Glu  Gln Ser Arg Asp Gly  Ser Arg His 
    1295                 1300                 1305             


Pro Gly  Phe His Gln Glu Asp  Arg Ala Ser His Gly  His Ser Ala 
    1310                 1315                 1320             


Asp Ser  Ser Arg Gln Ser Gly  Thr His His Thr Glu  Ser Ser Ser 
    1325                 1330                 1335             


His Gly  Gln Ala Val Ser Ser  His Glu Gln Ala Arg  Ser Ser Pro 
    1340                 1345                 1350             


Gly Glu  Arg His Gly Ser Arg  His Gln Gln Ser Ala  Asp Ser Ser 
    1355                 1360                 1365             


Arg His  Ser Gly Ile Gly His  Arg Gln Ala Ser Ser  Ala Val Arg 
    1370                 1375                 1380             


Asp Ser  Gly His Arg Gly Ser  Ser Gly Ser Gln Val  Thr Asn Ser 
    1385                 1390                 1395             


Glu Gly  His Ser Glu Asp Ser  Asp Thr Gln Ser Val  Ser Ala His 
    1400                 1405                 1410             


Gly Gln  Ala Gly Pro His Gln  Gln Ser His Lys Glu  Ser Ala Arg 
    1415                 1420                 1425             


Gly Gln  Ser Gly Glu Ser Ser  Gly Arg Ser Arg Ser  Phe Leu Tyr 
    1430                 1435                 1440             


Gln Val  Ser Ser His Glu Gln  Ser Glu Ser Thr His  Gly Gln Thr 
    1445                 1450                 1455             


Ala Pro  Ser Thr Gly Gly Arg  Gln Gly Ser Arg His  Glu Gln Ala 
    1460                 1465                 1470             


Arg Asn  Ser Ser Arg His Ser  Ala Ser Gln Asp Gly  Gln Asp Thr 
    1475                 1480                 1485             


Ile Arg  Gly His Pro Gly Ser  Ser Arg Gly Gly Arg  Gln Gly Ser 
    1490                 1495                 1500             


Tyr His  Glu Gln Ser Val Asp  Arg Ser Gly His Ser  Gly Tyr His 
    1505                 1510                 1515             


His Ser  His Thr Thr Pro Gln  Gly Arg Ser Asp Ala  Ser His Gly 
    1520                 1525                 1530             


Gln Ser  Gly Pro Arg Ser Ala  Ser Arg Gln Thr Arg  Asn Glu Glu 
    1535                 1540                 1545             


Gln Ser  Gly Asp Gly Ser Arg  His Ser Gly Ser Arg  His His Glu 
    1550                 1555                 1560             


Pro Ser  Thr Arg Ala Gly Ser  Ser Arg His Ser Gln  Val Gly Gln 
    1565                 1570                 1575             


Gly Glu  Ser Ala Gly Ser Lys  Thr Ser Arg Arg Gln  Gly Ser Ser 
    1580                 1585                 1590             


Val Ser  Gln Asp Arg Asp Ser  Glu Gly His Ser Glu  Asp Ser Glu 
    1595                 1600                 1605             


Arg Arg  Ser Glu Ser Ala Ser  Arg Asn His Tyr Gly  Ser Ala Arg 
    1610                 1615                 1620             


Glu Gln  Ser Arg His Gly Ser  Arg Asn Pro Arg Ser  His Gln Glu 
    1625                 1630                 1635             


Asp Arg  Ala Ser His Gly His  Ser Ala Glu Ser Ser  Arg Gln Ser 
    1640                 1645                 1650             


Gly Thr  Arg His Ala Glu Thr  Ser Ser Gly Gly Gln  Ala Ala Ser 
    1655                 1660                 1665             


Ser Gln  Glu Gln Ala Arg Ser  Ser Pro Gly Glu Arg  His Gly Ser 
    1670                 1675                 1680             


Arg His  Gln Gln Ser Ala Asp  Ser Ser Thr Asp Ser  Gly Thr Gly 
    1685                 1690                 1695             


Arg Arg  Gln Asp Ser Ser Val  Val Gly Asp Ser Gly  Asn Arg Gly 
    1700                 1705                 1710             


Ser Ser  Gly Ser Gln Ala Ser  Asp Ser Glu Gly His  Ser Glu Glu 
    1715                 1720                 1725             


Ser Asp  Thr Gln Ser Val Ser  Ala His Gly Gln Ala  Gly Pro His 
    1730                 1735                 1740             


Gln Gln  Ser His Gln Glu Ser  Thr Arg Gly Gln Ser  Gly Glu Arg 
    1745                 1750                 1755             


Ser Gly  Arg Ser Gly Ser Phe  Leu Tyr Gln Val Ser  Thr His Glu 
    1760                 1765                 1770             


Gln Ser  Glu Ser Ala His Gly  Arg Thr Gly Pro Ser  Thr Gly Gly 
    1775                 1780                 1785             


Arg Gln  Arg Ser Arg His Glu  Gln Ala Arg Asp Ser  Ser Arg His 
    1790                 1795                 1800             


Ser Ala  Ser Gln Glu Gly Gln  Asp Thr Ile Arg Gly  His Pro Gly 
    1805                 1810                 1815             


Ser Ser  Arg Gly Gly Arg Gln  Gly Ser His Tyr Glu  Gln Ser Val 
    1820                 1825                 1830             


Asp Ser  Ser Gly His Ser Gly  Ser His His Ser His  Thr Thr Ser 
    1835                 1840                 1845             


Gln Glu  Arg Ser Asp Val Ser  Arg Gly Gln Ser Gly  Ser Arg Ser 
    1850                 1855                 1860             


Val Ser  Arg Gln Thr Arg Asn  Glu Lys Gln Ser Gly  Asp Gly Ser 
    1865                 1870                 1875             


Arg His  Ser Gly Ser Arg His  His Glu Ala Ser Ser  Arg Ala Asp 
    1880                 1885                 1890             


Ser Ser  Arg His Ser Gln Val  Gly Gln Gly Gln Ser  Ser Gly Pro 
    1895                 1900                 1905             


Arg Thr  Ser Arg Asn Gln Gly  Ser Ser Val Ser Gln  Asp Ser Asp 
    1910                 1915                 1920             


Ser Gln  Gly His Ser Glu Asp  Ser Glu Arg Trp Ser  Gly Ser Ala 
    1925                 1930                 1935             


Ser Arg  Asn His Leu Gly Ser  Ala Trp Glu Gln Ser  Arg Asp Gly 
    1940                 1945                 1950             


Ser Arg  His Pro Gly Ser His  His Glu Asp Arg Ala  Gly His Gly 
    1955                 1960                 1965             


His Ser  Ala Asp Ser Ser Arg  Gln Ser Gly Thr Arg  His Thr Glu 
    1970                 1975                 1980             


Ser Ser  Ser Arg Gly Gln Ala  Ala Ser Ser His Glu  Gln Ala Arg 
    1985                 1990                 1995             


Ser Ser  Ala Gly Glu Arg His  Gly Ser His His Gln  Leu Gln Ser 
    2000                 2005                 2010             


Ala Asp  Ser Ser Arg His Ser  Gly Ile Gly His Gly  Gln Ala Ser 
    2015                 2020                 2025             


Ser Ala  Val Arg Asp Ser Gly  His Arg Gly Tyr Ser  Gly Ser Gln 
    2030                 2035                 2040             


Ala Ser  Asp Ser Glu Gly His  Ser Glu Asp Ser Asp  Thr Gln Ser 
    2045                 2050                 2055             


Val Ser  Ala Gln Gly Lys Ala  Gly Pro His Gln Gln  Ser His Lys 
    2060                 2065                 2070             


Glu Ser  Ala Arg Gly Gln Ser  Gly Glu Ser Ser Gly  Arg Ser Gly 
    2075                 2080                 2085             


Ser Phe  Leu Tyr Gln Val Ser  Thr His Glu Gln Ser  Glu Ser Thr 
    2090                 2095                 2100             


His Gly  Gln Ser Ala Pro Ser  Thr Gly Gly Arg Gln  Gly Ser His 
    2105                 2110                 2115             


Tyr Asp  Gln Ala Gln Asp Ser  Ser Arg His Ser Ala  Ser Gln Glu 
    2120                 2125                 2130             


Gly Gln  Asp Thr Ile Arg Gly  His Pro Gly Pro Ser  Arg Gly Gly 
    2135                 2140                 2145             


Arg Gln  Gly Ser His Gln Glu  Gln Ser Val Asp Arg  Ser Gly His 
    2150                 2155                 2160             


Ser Gly  Ser His His Ser His  Thr Thr Ser Gln Gly  Arg Ser Asp 
    2165                 2170                 2175             


Ala Ser  Arg Gly Gln Ser Gly  Ser Arg Ser Ala Ser  Arg Lys Thr 
    2180                 2185                 2190             


Tyr Asp  Lys Glu Gln Ser Gly  Asp Gly Ser Arg His  Ser Gly Ser 
    2195                 2200                 2205             


His His  His Glu Ala Ser Ser  Trp Ala Asp Ser Ser  Arg His Ser 
    2210                 2215                 2220             


Leu Val  Gly Gln Gly Gln Ser  Ser Gly Pro Arg Thr  Ser Arg Pro 
    2225                 2230                 2235             


Arg Gly  Ser Ser Val Ser Gln  Asp Ser Asp Ser Glu  Gly His Ser 
    2240                 2245                 2250             


Glu Asp  Ser Glu Arg Arg Ser  Gly Ser Ala Ser Arg  Asn His His 
    2255                 2260                 2265             


Gly Ser  Ala Gln Glu Gln Ser  Arg Asp Gly Ser Arg  His Pro Arg 
    2270                 2275                 2280             


Ser His  His Glu Asp Arg Ala  Gly His Gly His Ser  Ala Glu Ser 
    2285                 2290                 2295             


Ser Arg  Gln Ser Gly Thr His  His Ala Glu Asn Ser  Ser Gly Gly 
    2300                 2305                 2310             


Gln Ala  Ala Ser Ser His Glu  Gln Ala Arg Ser Ser  Ala Gly Glu 
    2315                 2320                 2325             


Arg His  Gly Ser His His Gln  Gln Ser Ala Asp Ser  Ser Arg His 
    2330                 2335                 2340             


Ser Gly  Ile Gly His Gly Gln  Ala Ser Ser Ala Val  Arg Asp Ser 
    2345                 2350                 2355             


Gly His  Arg Gly Ser Ser Gly  Ser Gln Ala Ser Asp  Ser Glu Gly 
    2360                 2365                 2370             


His Ser  Glu Asp Ser Asp Thr  Gln Ser Val Ser Ala  His Gly Gln 
    2375                 2380                 2385             


Ala Gly  Pro His Gln Gln Ser  His Gln Glu Ser Thr  Arg Gly Arg 
    2390                 2395                 2400             


Ser Ala  Gly Arg Ser Gly Arg  Ser Gly Ser Phe Leu  Tyr Gln Val 
    2405                 2410                 2415             


Ser Thr  His Glu Gln Ser Glu  Ser Ala His Gly Arg  Thr Gly Thr 
    2420                 2425                 2430             


Ser Thr  Gly Gly Arg Gln Gly  Ser His His Lys Gln  Ala Arg Asp 
    2435                 2440                 2445             


Ser Ser  Arg His Ser Thr Ser  Gln Glu Gly Gln Asp  Thr Ile His 
    2450                 2455                 2460             


Gly His  Pro Gly Ser Ser Ser  Gly Gly Arg Gln Gly  Ser His Tyr 
    2465                 2470                 2475             


Glu Gln  Leu Val Asp Arg Ser  Gly His Ser Gly Ser  His His Ser 
    2480                 2485                 2490             


His Thr  Thr Ser Gln Gly Arg  Ser Asp Ala Ser His  Gly His Ser 
    2495                 2500                 2505             


Gly Ser  Arg Ser Ala Ser Arg  Gln Thr Arg Asn Asp  Glu Gln Ser 
    2510                 2515                 2520             


Gly Asp  Gly Ser Arg His Ser  Gly Ser Arg His His  Glu Ala Ser 
    2525                 2530                 2535             


Ser Arg  Ala Asp Ser Ser Gly  His Ser Gln Val Gly  Gln Gly Gln 
    2540                 2545                 2550             


Ser Glu  Gly Pro Arg Thr Ser  Arg Asn Trp Gly Ser  Ser Phe Ser 
    2555                 2560                 2565             


Gln Asp  Ser Asp Ser Gln Gly  His Ser Glu Asp Ser  Glu Arg Trp 
    2570                 2575                 2580             


Ser Gly  Ser Ala Ser Arg Asn  His His Gly Ser Ala  Gln Glu Gln 
    2585                 2590                 2595             


Leu Arg  Asp Gly Ser Arg His  Pro Arg Ser His Gln  Glu Asp Arg 
    2600                 2605                 2610             


Ala Gly  His Gly His Ser Ala  Asp Ser Ser Arg Gln  Ser Gly Thr 
    2615                 2620                 2625             


Arg His  Thr Gln Thr Ser Ser  Gly Gly Gln Ala Ala  Ser Ser His 
    2630                 2635                 2640             


Glu Gln  Ala Arg Ser Ser Ala  Gly Glu Arg His Gly  Ser His His 
    2645                 2650                 2655             


Gln Gln  Ser Ala Asp Ser Ser  Arg His Ser Gly Ile  Gly His Gly 
    2660                 2665                 2670             


Gln Ala  Ser Ser Ala Val Arg  Asp Ser Gly His Arg  Gly Tyr Ser 
    2675                 2680                 2685             


Gly Ser  Gln Ala Ser Asp Asn  Glu Gly His Ser Glu  Asp Ser Asp 
    2690                 2695                 2700             


Thr Gln  Ser Val Ser Ala His  Gly Gln Ala Gly Ser  His Gln Gln 
    2705                 2710                 2715             


Ser His  Gln Glu Ser Ala Arg  Gly Arg Ser Gly Glu  Thr Ser Gly 
    2720                 2725                 2730             


His Ser  Gly Ser Phe Leu Tyr  Gln Val Ser Thr His  Glu Gln Ser 
    2735                 2740                 2745             


Glu Ser  Ser His Gly Trp Thr  Gly Pro Ser Thr Arg  Gly Arg Gln 
    2750                 2755                 2760             


Gly Ser  Arg His Glu Gln Ala  Gln Asp Ser Ser Arg  His Ser Ala 
    2765                 2770                 2775             


Ser Gln  Asp Gly Gln Asp Thr  Ile Arg Gly His Pro  Gly Ser Ser 
    2780                 2785                 2790             


Arg Gly  Gly Arg Gln Gly Tyr  His His Glu His Ser  Val Asp Ser 
    2795                 2800                 2805             


Ser Gly  His Ser Gly Ser His  His Ser His Thr Thr  Ser Gln Gly 
    2810                 2815                 2820             


Arg Ser  Asp Ala Ser Arg Gly  Gln Ser Gly Ser Arg  Ser Ala Ser 
    2825                 2830                 2835             


Arg Thr  Thr Arg Asn Glu Glu  Gln Ser Gly Asp Gly  Ser Arg His 
    2840                 2845                 2850             


Ser Gly  Ser Arg His His Glu  Ala Ser Thr His Ala  Asp Ile Ser 
    2855                 2860                 2865             


Arg His  Ser Gln Ala Val Gln  Gly Gln Ser Glu Gly  Ser Arg Arg 
    2870                 2875                 2880             


Ser Arg  Arg Gln Gly Ser Ser  Val Ser Gln Asp Ser  Asp Ser Glu 
    2885                 2890                 2895             


Gly His  Ser Glu Asp Ser Glu  Arg Trp Ser Gly Ser  Ala Ser Arg 
    2900                 2905                 2910             


Asn His  His Gly Ser Ala Gln  Glu Gln Leu Arg Asp  Gly Ser Arg 
    2915                 2920                 2925             


His Pro  Arg Ser His Gln Glu  Asp Arg Ala Gly His  Gly His Ser 
    2930                 2935                 2940             


Ala Asp  Ser Ser Arg Gln Ser  Gly Thr Arg His Thr  Gln Thr Ser 
    2945                 2950                 2955             


Ser Gly  Gly Gln Ala Ala Ser  Ser His Glu Gln Ala  Arg Ser Ser 
    2960                 2965                 2970             


Ala Gly  Glu Arg His Gly Ser  His His Gln Gln Ser  Ala Asp Ser 
    2975                 2980                 2985             


Ser Arg  His Ser Gly Ile Gly  His Gly Gln Ala Ser  Ser Ala Val 
    2990                 2995                 3000             


Arg Asp  Ser Gly His Arg Gly  Tyr Ser Gly Ser Gln  Ala Ser Asp 
    3005                 3010                 3015             


Asn Glu  Gly His Ser Glu Asp  Ser Asp Thr Gln Ser  Val Ser Ala 
    3020                 3025                 3030             


His Gly  Gln Ala Gly Ser His  Gln Gln Ser His Gln  Glu Ser Ala 
    3035                 3040                 3045             


Arg Gly  Arg Ser Gly Glu Thr  Ser Gly His Ser Gly  Ser Phe Leu 
    3050                 3055                 3060             


Tyr Gln  Val Ser Thr His Glu  Gln Ser Glu Ser Ser  His Gly Trp 
    3065                 3070                 3075             


Thr Gly  Pro Ser Thr Arg Gly  Arg Gln Gly Ser Arg  His Glu Gln 
    3080                 3085                 3090             


Ala Gln  Asp Ser Ser Arg His  Ser Ala Ser Gln Tyr  Gly Gln Asp 
    3095                 3100                 3105             


Thr Ile  Arg Gly His Pro Gly  Ser Ser Arg Gly Gly  Arg Gln Gly 
    3110                 3115                 3120             


Tyr His  His Glu His Ser Val  Asp Ser Ser Gly His  Ser Gly Ser 
    3125                 3130                 3135             


His His  Ser His Thr Thr Ser  Gln Gly Arg Ser Asp  Ala Ser Arg 
    3140                 3145                 3150             


Gly Gln  Ser Gly Ser Arg Ser  Ala Ser Arg Thr Thr  Arg Asn Glu 
    3155                 3160                 3165             


Glu Gln  Ser Gly Asp Ser Ser  Arg His Ser Val Ser  Arg His His 
    3170                 3175                 3180             


Glu Ala  Ser Thr His Ala Asp  Ile Ser Arg His Ser  Gln Ala Val 
    3185                 3190                 3195             


Gln Gly  Gln Ser Glu Gly Ser  Arg Arg Ser Arg Arg  Gln Gly Ser 
    3200                 3205                 3210             


Ser Val  Ser Gln Asp Ser Asp  Ser Glu Gly His Ser  Glu Asp Ser 
    3215                 3220                 3225             


Glu Arg  Trp Ser Gly Ser Ala  Ser Arg Asn His Arg  Gly Ser Val 
    3230                 3235                 3240             


Gln Glu  Gln Ser Arg His Gly  Ser Arg His Pro Arg  Ser His His 
    3245                 3250                 3255             


Glu Asp  Arg Ala Gly His Gly  His Ser Ala Asp Arg  Ser Arg Gln 
    3260                 3265                 3270             


Ser Gly  Thr Arg His Ala Glu  Thr Ser Ser Gly Gly  Gln Ala Ala 
    3275                 3280                 3285             


Ser Ser  His Glu Gln Ala Arg  Ser Ser Pro Gly Glu  Arg His Gly 
    3290                 3295                 3300             


Ser Arg  His Gln Gln Ser Ala  Asp Ser Ser Arg His  Ser Gly Ile 
    3305                 3310                 3315             


Pro Arg  Gly Gln Ala Ser Ser  Ala Val Arg Asp Ser  Arg His Trp 
    3320                 3325                 3330             


Gly Ser  Ser Gly Ser Gln Ala  Ser Asp Ser Glu Gly  His Ser Glu 
    3335                 3340                 3345             


Glu Ser  Asp Thr Gln Ser Val  Ser Gly His Gly Gln  Ala Gly Pro 
    3350                 3355                 3360             


His Gln  Gln Ser His Gln Glu  Ser Ala Arg Asp Arg  Ser Gly Gly 
    3365                 3370                 3375             


Arg Ser  Gly Arg Ser Gly Ser  Phe Leu Tyr Gln Val  Ser Thr His 
    3380                 3385                 3390             


Glu Gln  Ser Glu Ser Ala His  Gly Arg Thr Arg Thr  Ser Thr Gly 
    3395                 3400                 3405             


Arg Arg  Gln Gly Ser His His  Glu Gln Ala Arg Asp  Ser Ser Arg 
    3410                 3415                 3420             


His Ser  Ala Ser Gln Glu Gly  Gln Asp Thr Ile Arg  Gly His Pro 
    3425                 3430                 3435             


Gly Ser  Ser Arg Arg Gly Arg  Gln Gly Ser His Tyr  Glu Gln Ser 
    3440                 3445                 3450             


Val Asp  Arg Ser Gly His Ser  Gly Ser His His Ser  His Thr Thr 
    3455                 3460                 3465             


Ser Gln  Gly Arg Ser Asp Ala  Ser Arg Gly Gln Ser  Gly Ser Arg 
    3470                 3475                 3480             


Ser Ala  Ser Arg Gln Thr Arg  Asn Asp Glu Gln Ser  Gly Asp Gly 
    3485                 3490                 3495             


Ser Arg  His Ser Trp Ser His  His His Glu Ala Ser  Thr Gln Ala 
    3500                 3505                 3510             


Asp Ser  Ser Arg His Ser Gln  Ser Gly Gln Gly Gln  Ser Ala Gly 
    3515                 3520                 3525             


Pro Arg  Thr Ser Arg Asn Gln  Gly Ser Ser Val Ser  Gln Asp Ser 
    3530                 3535                 3540             


Asp Ser  Gln Gly His Ser Glu  Asp Ser Glu Arg Trp  Ser Gly Ser 
    3545                 3550                 3555             


Ala Ser  Arg Asn His Arg Gly  Ser Ala Gln Glu Gln  Ser Arg Asp 
    3560                 3565                 3570             


Gly Ser  Arg His Pro Thr Ser  His His Glu Asp Arg  Ala Gly His 
    3575                 3580                 3585             


Gly His  Ser Ala Glu Ser Ser  Arg Gln Ser Gly Thr  His His Ala 
    3590                 3595                 3600             


Glu Asn  Ser Ser Gly Gly Gln  Ala Ala Ser Ser His  Glu Gln Ala 
    3605                 3610                 3615             


Arg Ser  Ser Ala Gly Glu Arg  His Gly Ser His His  Gln Gln Ser 
    3620                 3625                 3630             


Ala Asp  Ser Ser Arg His Ser  Gly Ile Gly His Gly  Gln Ala Ser 
    3635                 3640                 3645             


Ser Ala  Val Arg Asp Ser Gly  His Arg Gly Ser Ser  Gly Ser Gln 
    3650                 3655                 3660             


Ala Ser  Asp Ser Glu Gly His  Ser Glu Asp Ser Asp  Thr Gln Ser 
    3665                 3670                 3675             


Val Ser  Ala His Gly Gln Ala  Gly Pro His Gln Gln  Ser His Gln 
    3680                 3685                 3690             


Glu Ser  Thr Arg Gly Arg Ser  Ala Gly Arg Ser Gly  Arg Ser Gly 
    3695                 3700                 3705             


Ser Phe  Leu Tyr Gln Val Ser  Thr His Glu Gln Ser  Glu Ser Ala 
    3710                 3715                 3720             


His Gly  Arg Ala Gly Pro Ser  Thr Gly Gly Arg Gln  Gly Ser Arg 
    3725                 3730                 3735             


His Glu  Gln Ala Arg Asp Ser  Ser Arg His Ser Ala  Ser Gln Glu 
    3740                 3745                 3750             


Gly Gln  Asp Thr Ile Arg Gly  His Pro Gly Ser Arg  Arg Gly Gly 
    3755                 3760                 3765             


Arg Gln  Gly Ser Tyr His Glu  Gln Ser Val Asp Arg  Ser Gly His 
    3770                 3775                 3780             


Ser Gly  Ser His His Ser His  Thr Thr Ser Gln Gly  Arg Ser Asp 
    3785                 3790                 3795             


Ala Ser  His Gly Gln Ser Gly  Ser Arg Ser Ala Ser  Arg Glu Thr 
    3800                 3805                 3810             


Arg Asn  Glu Glu Gln Ser Gly  Asp Gly Ser Arg His  Ser Gly Ser 
    3815                 3820                 3825             


Arg His  His Glu Ala Ser Thr  Gln Ala Asp Ser Ser  Arg His Ser 
    3830                 3835                 3840             


Gln Ser  Gly Gln Gly Glu Ser  Ala Gly Ser Arg Arg  Ser Arg Arg 
    3845                 3850                 3855             


Gln Gly  Ser Ser Val Ser Gln  Asp Ser Asp Ser Glu  Ala Tyr Pro 
    3860                 3865                 3870             


Glu Asp  Ser Glu Arg Arg Ser  Glu Ser Ala Ser Arg  Asn His His 
    3875                 3880                 3885             


Gly Ser  Ser Arg Glu Gln Ser  Arg Asp Gly Ser Arg  His Pro Gly 
    3890                 3895                 3900             


Ser Ser  His Arg Asp Thr Ala  Ser His Val Gln Ser  Ser Pro Val 
    3905                 3910                 3915             


Gln Ser  Asp Ser Ser Thr Ala  Lys Glu His Gly His  Phe Ser Ser 
    3920                 3925                 3930             


Leu Ser  Gln Asp Ser Ala Tyr  His Ser Gly Ile Gln  Ser Arg Gly 
    3935                 3940                 3945             


Ser Pro  His Ser Ser Ser Ser  Tyr His Tyr Gln Ser  Glu Gly Thr 
    3950                 3955                 3960             


Glu Arg  Gln Lys Gly Gln Ser  Gly Leu Val Trp Arg  His Gly Ser 
    3965                 3970                 3975             


Tyr Gly  Ser Ala Asp Tyr Asp  Tyr Gly Glu Ser Gly  Phe Arg His 
    3980                 3985                 3990             


Ser Gln  His Gly Ser Val Ser  Tyr Asn Ser Asn Pro  Val Val Phe 
    3995                 4000                 4005             


Lys Glu  Arg Ser Asp Ile Cys  Lys Ala Ser Ala Phe  Gly Lys Asp 
    4010                 4015                 4020             


His Pro  Arg Tyr Tyr Ala Thr  Tyr Ile Asn Lys Asp  Pro Gly Leu 
    4025                 4030                 4035             


Cys Gly  His Ser Ser Asp Ile  Ser Lys Gln Leu Gly  Phe Ser Gln 
    4040                 4045                 4050             


Ser Gln  Arg Tyr Tyr Tyr Tyr  Glu 
    4055                 4060     


<210> 2
<211> 346
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Gln Ser Gly Glu Ser Ser Gly Arg Ser Arg Ser Phe Leu Tyr Gln 
1               5                   10                  15      


Val Ser Ser His Glu Gln Ser Glu Ser Thr His Gly Gln Thr Ala Pro 
            20                  25                  30          


Ser Thr Gly Gly Arg Gln Gly Ser Arg His Glu Gln Ala Arg Asn Ser 
        35                  40                  45              


Ser Arg His Ser Ala Ser Gln Asp Gly Gln Asp Thr Ile Arg Gly His 
    50                  55                  60                  


Pro Gly Ser Ser Arg Gly Gly Arg Gln Gly Ser Tyr His Glu Gln Ser 
65                  70                  75                  80  


Val Asp Arg Ser Gly His Ser Gly Tyr His His Ser His Thr Thr Pro 
                85                  90                  95      


Gln Gly Arg Ser Asp Ala Ser His Gly Gln Ser Gly Pro Arg Ser Ala 
            100                 105                 110         


Ser Arg Gln Thr Arg Asn Glu Glu Gln Ser Gly Asp Gly Ser Arg His 
        115                 120                 125             


Ser Gly Ser Arg His His Glu Pro Ser Thr Arg Ala Gly Ser Ser Arg 
    130                 135                 140                 


His Ser Gln Val Gly Gln Gly Glu Ser Ala Gly Ser Lys Thr Ser Arg 
145                 150                 155                 160 


Arg Gln Gly Ser Ser Val Ser Gln Asp Arg Asp Ser Glu Gly His Ser 
                165                 170                 175     


Glu Asp Ser Glu Arg Arg Ser Glu Ser Ala Ser Arg Asn His Tyr Gly 
            180                 185                 190         


Ser Ala Arg Glu Gln Ser Arg His Gly Ser Arg Asn Pro Arg Ser His 
        195                 200                 205             


Gln Glu Asp Arg Ala Ser His Gly His Ser Ala Glu Ser Ser Arg Gln 
    210                 215                 220                 


Ser Gly Thr Arg His Ala Glu Thr Ser Ser Gly Gly Gln Ala Ala Ser 
225                 230                 235                 240 


Ser Gln Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg His Gly Ser Arg 
                245                 250                 255     


His Gln Gln Ser Ala Asp Ser Ser Thr Asp Ser Gly Thr Gly Arg Arg 
            260                 265                 270         


Gln Asp Ser Ser Val Val Gly Asp Ser Gly Asn Arg Gly Ser Ser Gly 
        275                 280                 285             


Ser Gln Ala Ser Asp Ser Glu Gly His Ser Glu Glu Ser Asp Thr Gln 
    290                 295                 300                 


Ser Val Ser Ala His Gly Gln Ala Gly Pro His Gln Gln Ser His Gln 
305                 310                 315                 320 


Glu Ser Thr Arg Gly Gln Ser Gly Glu Arg Ser Gly Arg Ser Gly Ser 
                325                 330                 335     


Phe Leu Tyr Gln Val Ser Thr His Glu Gln 
            340                 345     


<210> 3
<211> 356
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Met Gln Ser Gly Glu Ser Ser Gly Arg Ser Arg Ser Phe Leu Tyr Gln 
1               5                   10                  15      


Val Ser Ser His Glu Gln Ser Glu Ser Thr His Gly Gln Thr Ala Pro 
            20                  25                  30          


Ser Thr Gly Gly Arg Gln Gly Ser Arg His Glu Gln Ala Arg Asn Ser 
        35                  40                  45              


Ser Arg His Ser Ala Ser Gln Asp Gly Gln Asp Thr Ile Arg Gly His 
    50                  55                  60                  


Pro Gly Ser Ser Arg Gly Gly Arg Gln Gly Ser Tyr His Glu Gln Ser 
65                  70                  75                  80  


Val Asp Arg Ser Gly His Ser Gly Tyr His His Ser His Thr Thr Pro 
                85                  90                  95      


Gln Gly Arg Ser Asp Ala Ser His Gly Gln Ser Gly Pro Arg Ser Ala 
            100                 105                 110         


Ser Arg Gln Thr Arg Asn Glu Glu Gln Ser Gly Asp Gly Ser Arg His 
        115                 120                 125             


Ser Gly Ser Arg His His Glu Pro Ser Thr Arg Ala Gly Ser Ser Arg 
    130                 135                 140                 


His Ser Gln Val Gly Gln Gly Glu Ser Ala Gly Ser Lys Thr Ser Arg 
145                 150                 155                 160 


Arg Gln Gly Ser Ser Val Ser Gln Asp Arg Asp Ser Glu Gly His Ser 
                165                 170                 175     


Glu Asp Ser Glu Arg Arg Ser Glu Ser Ala Ser Arg Asn His Tyr Gly 
            180                 185                 190         


Ser Ala Arg Glu Gln Ser Arg His Gly Ser Arg Asn Pro Arg Ser His 
        195                 200                 205             


Gln Glu Asp Arg Ala Ser His Gly His Ser Ala Glu Ser Ser Arg Gln 
    210                 215                 220                 


Ser Gly Thr Arg His Ala Glu Thr Ser Ser Gly Gly Gln Ala Ala Ser 
225                 230                 235                 240 


Ser Gln Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg His Gly Ser Arg 
                245                 250                 255     


His Gln Gln Ser Ala Asp Ser Ser Thr Asp Ser Gly Thr Gly Arg Arg 
            260                 265                 270         


Gln Asp Ser Ser Val Val Gly Asp Ser Gly Asn Arg Gly Ser Ser Gly 
        275                 280                 285             


Ser Gln Ala Ser Asp Ser Glu Gly His Ser Glu Glu Ser Asp Thr Gln 
    290                 295                 300                 


Ser Val Ser Ala His Gly Gln Ala Gly Pro His Gln Gln Ser His Gln 
305                 310                 315                 320 


Glu Ser Thr Arg Gly Gln Ser Gly Glu Arg Ser Gly Arg Ser Gly Ser 
                325                 330                 335     


Phe Leu Tyr Gln Val Ser Thr His Glu Gln Arg Met Arg Arg Met Arg 
            340                 345                 350         


Arg Met Arg Arg 
        355     


<210> 4
<211> 337
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Glu Ser Thr His Gly Gln Thr Ala Pro Ser Thr Gly Gly Arg Gln 
1               5                   10                  15      


Gly Ser Arg His Glu Gln Ala Arg Asn Ser Ser Arg His Ser Ala Ser 
            20                  25                  30          


Gln Asp Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg Gly 
        35                  40                  45              


Gly Arg Gln Gly Ser Tyr His Glu Gln Ser Val Asp Arg Ser Gly His 
    50                  55                  60                  


Ser Gly Tyr His His Ser His Thr Thr Pro Gln Gly Arg Ser Asp Ala 
65                  70                  75                  80  


Ser His Gly Gln Ser Gly Pro Arg Ser Ala Ser Arg Gln Thr Arg Asn 
                85                  90                  95      


Glu Glu Gln Ser Gly Asp Gly Ser Arg His Ser Gly Ser Arg His His 
            100                 105                 110         


Glu Pro Ser Thr Arg Ala Gly Ser Ser Arg His Ser Gln Val Gly Gln 
        115                 120                 125             


Gly Glu Ser Ala Gly Ser Lys Thr Ser Arg Arg Gln Gly Ser Ser Val 
    130                 135                 140                 


Ser Gln Asp Arg Asp Ser Glu Gly His Ser Glu Asp Ser Glu Arg Arg 
145                 150                 155                 160 


Ser Glu Ser Ala Ser Arg Asn His Tyr Gly Ser Ala Arg Glu Gln Ser 
                165                 170                 175     


Arg His Gly Ser Arg Asn Pro Arg Ser His Gln Glu Asp Arg Ala Ser 
            180                 185                 190         


His Gly His Ser Ala Glu Ser Ser Arg Gln Ser Gly Thr Arg His Ala 
        195                 200                 205             


Glu Thr Ser Ser Gly Gly Gln Ala Ala Ser Ser Gln Glu Gln Ala Arg 
    210                 215                 220                 


Ser Ser Pro Gly Glu Arg His Gly Ser Arg His Gln Gln Ser Ala Asp 
225                 230                 235                 240 


Ser Ser Thr Asp Ser Gly Thr Gly Arg Arg Gln Asp Ser Ser Val Val 
                245                 250                 255     


Gly Asp Ser Gly Asn Arg Gly Ser Ser Gly Ser Gln Ala Ser Asp Ser 
            260                 265                 270         


Glu Gly His Ser Glu Glu Ser Asp Thr Gln Ser Val Ser Ala His Gly 
        275                 280                 285             


Gln Ala Gly Pro His Gln Gln Ser His Gln Glu Ser Thr Arg Gly Gln 
    290                 295                 300                 


Ser Gly Glu Arg Ser Gly Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser 
305                 310                 315                 320 


Thr His Glu Gln Ser Glu Ser Arg Met Arg Arg Met Arg Arg Met Arg 
                325                 330                 335     


Arg 
    


<210> 5
<211> 336
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Arg Asn Glu Glu Gln Ser Gly Asp Gly Ser Arg His Ser Gly Ser 
1               5                   10                  15      


Arg His His Glu Pro Ser Thr Arg Ala Gly Ser Ser Arg His Ser Gln 
            20                  25                  30          


Val Gly Gln Gly Glu Ser Ala Gly Ser Lys Thr Ser Arg Arg Gln Gly 
        35                  40                  45              


Ser Ser Val Ser Gln Asp Arg Asp Ser Glu Gly His Ser Glu Asp Ser 
    50                  55                  60                  


Glu Arg Arg Ser Glu Ser Ala Ser Arg Asn His Tyr Gly Ser Ala Arg 
65                  70                  75                  80  


Glu Gln Ser Arg His Gly Ser Arg Asn Pro Arg Ser His Gln Glu Asp 
                85                  90                  95      


Arg Ala Ser His Gly His Ser Ala Glu Ser Ser Arg Gln Ser Gly Thr 
            100                 105                 110         


Arg His Ala Glu Thr Ser Ser Gly Gly Gln Ala Ala Ser Ser Gln Glu 
        115                 120                 125             


Gln Ala Arg Ser Ser Pro Gly Glu Arg His Gly Ser Arg His Gln Gln 
    130                 135                 140                 


Ser Ala Asp Ser Ser Thr Asp Ser Gly Thr Gly Arg Arg Gln Asp Ser 
145                 150                 155                 160 


Ser Val Val Gly Asp Ser Gly Asn Arg Gly Ser Ser Gly Ser Gln Ala 
                165                 170                 175     


Ser Asp Ser Glu Gly His Ser Glu Glu Ser Asp Thr Gln Ser Val Ser 
            180                 185                 190         


Ala His Gly Gln Ala Gly Pro His Gln Gln Ser His Gln Glu Ser Thr 
        195                 200                 205             


Arg Gly Gln Ser Gly Glu Arg Ser Gly Arg Ser Gly Ser Phe Leu Tyr 
    210                 215                 220                 


Gln Val Ser Thr His Glu Gln Ser Glu Ser Ala His Gly Arg Thr Gly 
225                 230                 235                 240 


Pro Ser Thr Gly Gly Arg Gln Arg Ser Arg His Glu Gln Ala Arg Asp 
                245                 250                 255     


Ser Ser Arg His Ser Ala Ser Gln Glu Gly Gln Asp Thr Ile Arg Gly 
            260                 265                 270         


His Pro Gly Ser Ser Arg Gly Gly Arg Gln Gly Ser His Tyr Glu Gln 
        275                 280                 285             


Ser Val Asp Ser Ser Gly His Ser Gly Ser His His Ser His Thr Thr 
    290                 295                 300                 


Ser Gln Glu Arg Ser Asp Val Ser Arg Gly Gln Ser Gly Ser Arg Ser 
305                 310                 315                 320 


Val Ser Arg Gln Thr Arg Arg Met Arg Arg Met Arg Arg Met Arg Arg 
                325                 330                 335     


<210> 6
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Arg Asn Glu Glu Gln Ser Gly Asp Gly Ser Arg His Ser Gly Ser 
1               5                   10                  15      


Arg His His Glu Pro Ser Thr Arg Ala Gly Ser Ser Arg His Ser Gln 
            20                  25                  30          


Val Gly Gln Gly Glu Ser Ala Gly Ser Lys Thr Ser Arg Arg Gln Gly 
        35                  40                  45              


Ser Ser Val Ser Gln Asp Arg Asp Ser Glu Gly His Ser Glu Asp Ser 
    50                  55                  60                  


Glu Arg Arg Ser Glu Ser Ala Ser Arg Asn His Tyr Gly Ser Ala Arg 
65                  70                  75                  80  


Glu Gln Ser Arg His Gly Ser Arg Asn Pro Arg Ser His Gln Glu Asp 
                85                  90                  95      


Arg Ala Ser His Gly His Ser Ala Glu Ser Ser Arg Gln Ser Gly Thr 
            100                 105                 110         


Arg His Ala Glu Thr Ser Ser Gly Gly Gln Ala Ala Ser Ser Gln Glu 
        115                 120                 125             


Gln Ala Arg Ser Ser Pro Gly Glu Arg His Gly Ser Arg His Gln Gln 
    130                 135                 140                 


Ser Ala Asp Ser Ser Thr Asp Ser Gly Thr Gly Arg Arg Gln Asp Ser 
145                 150                 155                 160 


Ser Val Val Gly Asp Ser Gly Asn Arg Gly Ser Ser Gly Ser Gln Ala 
                165                 170                 175     


Ser Asp Ser Glu Gly His Ser Glu Glu Ser Asp Thr Gln Ser Val Ser 
            180                 185                 190         


Ala His Gly Gln Ala Gly Pro His Gln Gln Ser His Gln Glu Ser Thr 
        195                 200                 205             


Arg Gly Gln Ser Gly Glu Arg Ser Gly Arg Ser Gly Ser Phe Leu Tyr 
    210                 215                 220                 


Gln Val Ser Thr His Glu Gln Ser Glu Ser Arg Met Arg Arg Met Arg 
225                 230                 235                 240 


Arg Met Arg Arg 
                


<210> 7

<400> 7
000


<210> 8
<211> 352
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Met Arg Ser Arg Ser Phe Leu Tyr Gln Val Ser Ser His Glu Gln Ser 
1               5                   10                  15      


Glu Ser Thr His Gly Gln Thr Ala Pro Ser Thr Gly Gly Arg Gln Gly 
            20                  25                  30          


Ser Arg His Glu Gln Ala Arg Asn Ser Ser Arg His Ser Ala Ser Gln 
        35                  40                  45              


Asp Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg Gly Gly 
    50                  55                  60                  


Arg Gln Gly Ser Tyr His Glu Gln Ser Val Asp Arg Ser Gly His Ser 
65                  70                  75                  80  


Gly Tyr His His Ser His Thr Thr Pro Gln Gly Arg Ser Asp Ala Ser 
                85                  90                  95      


His Gly Gln Ser Gly Pro Arg Ser Ala Ser Arg Gln Thr Arg Asn Glu 
            100                 105                 110         


Glu Gln Ser Gly Asp Gly Ser Arg His Ser Gly Ser Arg His His Glu 
        115                 120                 125             


Ala Ser Thr Arg Ala Asp Ser Ser Arg His Ser Gln Val Gly Gln Gly 
    130                 135                 140                 


Gln Ser Ser Gly Ser Arg Thr Ser Arg Arg Gln Gly Ser Ser Val Ser 
145                 150                 155                 160 


Gln Asp Ser Asp Ser Glu Gly His Ser Glu Asp Ser Glu Arg Arg Ser 
                165                 170                 175     


Gly Ser Ala Ser Arg Asn His Tyr Gly Ser Ala Gln Glu Gln Ser Arg 
            180                 185                 190         


Asp Gly Ser Arg His Pro Arg Ser His Gln Glu Asp Arg Ala Ser His 
        195                 200                 205             


Gly His Ser Ala Glu Ser Ser Arg Gln Ser Gly Thr Arg His Ala Glu 
    210                 215                 220                 


Thr Ser Ser Gly Gly Gln Ala Ala Ser Ser His Glu Gln Ala Arg Ser 
225                 230                 235                 240 


Ser Pro Gly Glu Arg His Gly Ser Arg His Gln Gln Ser Ala Asp Ser 
                245                 250                 255     


Ser Arg His Ser Gly Ile Gly His Gly Gln Ala Ser Ser Ala Val Arg 
            260                 265                 270         


Asp Ser Gly His Arg Gly Ser Ser Gly Ser Gln Ala Ser Asp Ser Glu 
        275                 280                 285             


Gly His Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Ala His Gly Gln 
    290                 295                 300                 


Ala Gly Pro His Gln Gln Ser His Gln Glu Ser Ala Arg Gly Arg Ser 
305                 310                 315                 320 


Gly Glu Arg Ser Gly Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr 
                325                 330                 335     


His Glu Gln Ser Glu Ser Arg Met Arg Arg Met Arg Arg Met Arg Arg 
            340                 345                 350         


<210> 9
<211> 328
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (19)..(20)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (23)..(24)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (30)..(31)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (34)..(36)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (55)..(58)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (63)..(65)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (67)..(68)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (70)..(71)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (105)..(108)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (124)..(125)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (129)..(130)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (135)..(136)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (139)..(140)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (149)..(150)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (161)..(162)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (182)..(183)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (194)..(195)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (218)..(220)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (254)..(255)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (258)..(259)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (271)..(273)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (282)..(283)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (300)..(301)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (314)..(315)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (318)..(319)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Any amino acid

<400> 9
Xaa Leu Tyr Gln Val Ser Thr His Xaa Gln Xaa Asp Ser Xaa His Gly 
1               5                   10                  15      


Xaa Thr Xaa Xaa Ser Thr Xaa Xaa Arg Gln Xaa Ser His Xaa Xaa Gln 
            20                  25                  30          


Ala Xaa Xaa Xaa Ser Arg His Ser Xaa Ser Gln Xaa Gly Gln Asp Thr 
        35                  40                  45              


Ile Arg Gly His Pro Gly Xaa Xaa Xaa Xaa Gly Arg Gln Gly Xaa Xaa 
    50                  55                  60                  


Xaa Glu Xaa Xaa Val Xaa Xaa Ser Gly His Ser Gly Xaa His His Ser 
65                  70                  75                  80  


His Thr Thr Xaa Gln Xaa Arg Ser Asp Ala Ser His Gly Xaa Ser Gly 
                85                  90                  95      


Xaa Arg Ser Ala Ser Arg Xaa Thr Xaa Xaa Xaa Xaa Gln Ser Xaa Asp 
            100                 105                 110         


Xaa Thr Arg His Ser Xaa Ser Arg His His Glu Xaa Xaa Ser Xaa Ala 
        115                 120                 125             


Xaa Xaa Ser Xaa His Ser Xaa Xaa Gly Gln Xaa Xaa Ser Xaa Gly Xaa 
    130                 135                 140                 


Arg Xaa Ser Arg Xaa Xaa Gly Ser Ser Xaa Ser Gln Asp Xaa Asp Ser 
145                 150                 155                 160 


Xaa Xaa His Ser Glu Asp Ser Glu Arg Xaa Ser Xaa Ser Ala Ser Arg 
                165                 170                 175     


Asn His Xaa Gly Ser Xaa Xaa Glu Gln Xaa Arg Xaa Gly Ser Arg Xaa 
            180                 185                 190         


Pro Xaa Xaa His Xaa Glu Asp Arg Ala Xaa His Gly His Ser Ala Asp 
        195                 200                 205             


Xaa Ser Arg Lys Ser Gly Thr Xaa His Xaa Xaa Xaa Ser Ser Xaa Gly 
    210                 215                 220                 


Gln Ala Ala Ser Ser Xaa Glu Gln Ala Arg Ser Ser Xaa Gly Glu Arg 
225                 230                 235                 240 


His Gly Ser Arg His Gln Xaa Gln Ser Ala Asp Ser Ser Xaa Xaa Ser 
                245                 250                 255     


Gly Xaa Xaa His Xaa Gln Xaa Ser Ser Ala Val Xaa Asp Ser Xaa Xaa 
            260                 265                 270         


Xaa Gly Xaa Ser Gly Ser Gln Ala Thr Xaa Xaa Glu Gly His Ser Glu 
        275                 280                 285             


Asp Ser Asp Thr Gln Ser Val Ser Gly Xaa Gly Xaa Xaa Gly Xaa His 
    290                 295                 300                 


Gln Gln Ser His Xaa Glu Ser Xaa Arg Xaa Xaa Ser Gly Xaa Xaa Ser 
305                 310                 315                 320 


Xaa Arg Ser Xaa Ser Phe Leu Tyr 
                325             


<210> 10
<211> 416
<212> PRT
<213> Homo sapiens

<400> 10
Ala Gly Pro His Gln Gln Ser His Gln Glu Ser Thr Arg Gly Arg Ser 
1               5                   10                  15      


Ala Gly Arg Ser Gly Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr 
            20                  25                  30          


His Glu Gln Ser Glu Ser Ala His Gly Arg Thr Gly Thr Ser Thr Gly 
        35                  40                  45              


Gly Arg Gln Gly Ser His His Gln Gln Ala Arg Asp Ser Ser Arg His 
    50                  55                  60                  


Ser Thr Ser Gln Glu Gly Gln Asp Thr Ile His Gly His Arg Gly Ser 
65                  70                  75                  80  


Ser Ser Gly Gly Arg Gln Gly Ser His Tyr Glu Gln Leu Val Asp Arg 
                85                  90                  95      


Ser Gly His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg 
            100                 105                 110         


Ser Asp Ala Ser His Gly His Ser Gly Ser Arg Ser Ala Ser Arg Gln 
        115                 120                 125             


Thr Arg Asn Asp Glu Gln Ser Gly Asp Gly Ser Arg His Ser Gly Ser 
    130                 135                 140                 


Arg His His Glu Ala Ser Ser Arg Ala Asp Ser Ser Gly His Ser Gln 
145                 150                 155                 160 


Val Gly Gln Gly Gln Ser Glu Gly Pro Arg Thr Ser Arg Asn Trp Gly 
                165                 170                 175     


Ser Ser Phe Ser Gln Asp Ser Asp Ser Gln Gly His Ser Glu Asp Ser 
            180                 185                 190         


Glu Arg Trp Ser Gly Ser Ala Ser Arg Asn His His Gly Ser Ala Gln 
        195                 200                 205             


Glu Gln Leu Arg Asp Gly Ser Arg His Pro Arg Ser His Gln Glu Asp 
    210                 215                 220                 


Arg Ala Gly His Gly His Ser Ala Asp Ser Ser Arg Gln Ser Gly Thr 
225                 230                 235                 240 


Arg His Thr Gln Thr Ser Ser Gly Gly Gln Ala Ala Ser Ser His Glu 
                245                 250                 255     


Gln Ala Arg Ser Ser Ala Gly Asp Arg His Gly Ser His His Gln Gln 
            260                 265                 270         


Ser Ala Asp Ser Ser Arg His Ser Gly Ile Gly His Gly Gln Ala Ser 
        275                 280                 285             


Ser Ala Val Arg Asp Ser Gly His Arg Gly Tyr Ser Gly Ser Gln Ala 
    290                 295                 300                 


Ser Asp Asn Glu Gly His Ser Glu Asp Ser Asp Thr Gln Ser Val Ser 
305                 310                 315                 320 


Ala His Gly Gln Ala Gly Ser His Gln Gln Ser His Gln Glu Ser Ala 
                325                 330                 335     


Arg Gly Arg Ser Gly Glu Thr Ser Gly His Ser Gly Ser Phe Leu Tyr 
            340                 345                 350         


Gln Val Ser Thr His Glu Gln Ser Glu Ser Ser His Gly Trp Thr Gly 
        355                 360                 365             


Pro Ser Thr Arg Gly Arg Gln Gly Ser Arg His Glu Gln Ala Gln Asp 
    370                 375                 380                 


Ser Ser Arg His Ser Ala Ser Gln Asp Gly Gln Asp Thr Ile Arg Gly 
385                 390                 395                 400 


His Pro Gly Ser Ser Arg Gly Gly Arg Gln Gly Tyr His His Glu Gln 
                405                 410                 415     


<210> 11
<211> 4061
<212> PRT
<213> Homo sapiens

<400> 11
Met Ser Thr Leu Leu Glu Asn Ile Phe Ala Ile Ile Asn Leu Phe Lys 
1               5                   10                  15      


Gln Tyr Ser Lys Lys Asp Lys Asn Thr Asp Thr Leu Ser Lys Lys Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Lys Glu Phe Arg Gln Ile Leu Lys Asn Pro 
        35                  40                  45              


Asp Asp Pro Asp Met Val Asp Val Phe Met Asp His Leu Asp Ile Asp 
    50                  55                  60                  


His Asn Lys Lys Ile Asp Phe Thr Glu Phe Leu Leu Met Val Phe Lys 
65                  70                  75                  80  


Leu Ala Gln Ala Tyr Tyr Glu Ser Thr Arg Lys Glu Asn Leu Pro Ile 
                85                  90                  95      


Ser Gly His Lys His Arg Lys His Ser His His Asp Lys His Glu Asp 
            100                 105                 110         


Asn Lys Gln Glu Glu Asn Lys Glu Asn Arg Lys Arg Pro Ser Ser Leu 
        115                 120                 125             


Glu Arg Arg Asn Asn Arg Lys Gly Asn Lys Gly Arg Ser Lys Ser Pro 
    130                 135                 140                 


Arg Glu Thr Gly Gly Lys Arg His Glu Ser Ser Ser Glu Lys Lys Glu 
145                 150                 155                 160 


Arg Lys Gly Tyr Ser Pro Thr His Arg Glu Glu Glu Tyr Gly Lys Asn 
                165                 170                 175     


His His Asn Ser Ser Lys Lys Glu Lys Asn Lys Thr Glu Asn Thr Arg 
            180                 185                 190         


Leu Gly Asp Asn Arg Lys Arg Leu Ser Glu Arg Leu Glu Glu Lys Glu 
        195                 200                 205             


Asp Asn Glu Glu Gly Val Tyr Asp Tyr Glu Asn Thr Gly Arg Met Thr 
    210                 215                 220                 


Gln Lys Trp Ile Gln Ser Gly His Ile Ala Thr Tyr Tyr Thr Ile Gln 
225                 230                 235                 240 


Asp Glu Ala Tyr Asp Thr Thr Asp Ser Leu Leu Glu Glu Asn Lys Ile 
                245                 250                 255     


Tyr Glu Arg Ser Arg Ser Ser Asp Gly Lys Ser Ser Ser Gln Val Asn 
            260                 265                 270         


Arg Ser Arg His Glu Asn Thr Ser Gln Val Pro Leu Gln Glu Ser Arg 
        275                 280                 285             


Thr Arg Lys Arg Arg Gly Ser Arg Val Ser Gln Asp Arg Asp Ser Glu 
    290                 295                 300                 


Gly His Ser Glu Asp Ser Glu Arg His Ser Gly Ser Ala Ser Arg Asn 
305                 310                 315                 320 


His His Gly Ser Ala Trp Glu Gln Ser Arg Asp Gly Ser Arg His Pro 
                325                 330                 335     


Arg Ser His Asp Glu Asp Arg Ala Ser His Gly His Ser Ala Asp Ser 
            340                 345                 350         


Ser Arg Gln Ser Gly Thr Arg His Ala Glu Thr Ser Ser Arg Gly Gln 
        355                 360                 365             


Thr Ala Ser Ser His Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg His 
    370                 375                 380                 


Gly Ser Gly His Gln Gln Ser Ala Asp Ser Ser Arg His Ser Ala Thr 
385                 390                 395                 400 


Gly Arg Gly Gln Ala Ser Ser Ala Val Ser Asp Arg Gly His Arg Gly 
                405                 410                 415     


Ser Ser Gly Ser Gln Ala Ser Asp Ser Glu Gly His Ser Glu Asn Ser 
            420                 425                 430         


Asp Thr Gln Ser Val Ser Gly His Gly Lys Ala Gly Leu Arg Gln Gln 
        435                 440                 445             


Ser His Gln Glu Ser Thr Arg Gly Arg Ser Gly Glu Arg Ser Gly Arg 
    450                 455                 460                 


Ser Gly Ser Ser Leu Tyr Gln Val Ser Thr His Glu Gln Pro Asp Ser 
465                 470                 475                 480 


Ala His Gly Arg Thr Gly Thr Ser Thr Gly Gly Arg Gln Gly Ser His 
                485                 490                 495     


His Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala Ser Gln Glu Gly 
            500                 505                 510         


Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg Gly Gly Arg Gln 
        515                 520                 525             


Gly Ser His His Glu Gln Ser Val Asn Arg Ser Gly His Ser Gly Ser 
    530                 535                 540                 


His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp Ala Ser His Gly 
545                 550                 555                 560 


Gln Ser Gly Ser Arg Ser Ala Ser Arg Gln Thr Arg Asn Glu Glu Gln 
                565                 570                 575     


Ser Gly Asp Gly Thr Arg His Ser Gly Ser Arg His His Glu Ala Ser 
            580                 585                 590         


Ser Gln Ala Asp Ser Ser Arg His Ser Gln Val Gly Gln Gly Gln Ser 
        595                 600                 605             


Ser Gly Pro Arg Thr Ser Arg Asn Gln Gly Ser Ser Val Ser Gln Asp 
    610                 615                 620                 


Ser Asp Ser Gln Gly His Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser 
625                 630                 635                 640 


Ala Ser Arg Asn His His Gly Ser Ala Gln Glu Gln Ser Arg Asp Gly 
                645                 650                 655     


Ser Arg His Pro Arg Ser His His Glu Asp Arg Ala Gly His Gly His 
            660                 665                 670         


Ser Ala Asp Ser Ser Arg Lys Ser Gly Thr Arg His Thr Gln Asn Ser 
        675                 680                 685             


Ser Ser Gly Gln Ala Ala Ser Ser His Glu Gln Ala Arg Ser Ser Ala 
    690                 695                 700                 


Gly Glu Arg His Gly Ser Arg His Gln Leu Gln Ser Ala Asp Ser Ser 
705                 710                 715                 720 


Arg His Ser Gly Thr Gly His Gly Gln Ala Ser Ser Ala Val Arg Asp 
                725                 730                 735     


Ser Gly His Arg Gly Ser Ser Gly Ser Gln Ala Thr Asp Ser Glu Gly 
            740                 745                 750         


His Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Gly His Gly Gln Ala 
        755                 760                 765             


Gly His His Gln Gln Ser His Gln Glu Ser Ala Arg Asp Arg Ser Gly 
    770                 775                 780                 


Glu Arg Ser Arg Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His 
785                 790                 795                 800 


Lys Gln Ser Glu Ser Ser His Gly Trp Thr Gly Pro Ser Thr Gly Val 
                805                 810                 815     


Arg Gln Gly Ser His His Glu Gln Ala Arg Asp Asn Ser Arg His Ser 
            820                 825                 830         


Ala Ser Gln Asp Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser 
        835                 840                 845             


Arg Arg Gly Arg Gln Gly Ser His His Glu Gln Ser Val Asp Arg Ser 
    850                 855                 860                 


Gly His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser 
865                 870                 875                 880 


Asp Ala Ser Arg Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Thr Thr 
                885                 890                 895     


Arg Asn Glu Glu Gln Ser Arg Asp Gly Ser Arg His Ser Gly Ser Arg 
            900                 905                 910         


His His Glu Ala Ser Ser His Ala Asp Ile Ser Arg His Ser Gln Ala 
        915                 920                 925             


Gly Gln Gly Gln Ser Glu Gly Ser Arg Thr Ser Arg Arg Gln Gly Ser 
    930                 935                 940                 


Ser Val Ser Gln Asp Ser Asp Ser Glu Gly His Ser Glu Asp Ser Glu 
945                 950                 955                 960 


Arg Trp Ser Gly Ser Ala Ser Arg Asn His Arg Gly Ser Ala Gln Glu 
                965                 970                 975     


Gln Ser Arg His Gly Ser Arg His Pro Arg Ser His His Glu Asp Arg 
            980                 985                 990         


Ala Gly His Gly His Ser Ala Asp  Ser Ser Arg Gln Ser  Gly Thr Pro 
        995                 1000                 1005             


His Ala  Glu Thr Ser Ser Gly  Gly Gln Ala Ala Ser  Ser His Glu 
    1010                 1015                 1020             


Gln Ala  Arg Ser Ser Pro Gly  Glu Arg His Gly Ser  Arg His Gln 
    1025                 1030                 1035             


Gln Ser  Ala Asp Ser Ser Arg  His Ser Gly Ile Pro  Arg Arg Gln 
    1040                 1045                 1050             


Ala Ser  Ser Ala Val Arg Asp  Ser Gly His Trp Gly  Ser Ser Gly 
    1055                 1060                 1065             


Ser Gln  Ala Ser Asp Ser Glu  Gly His Ser Glu Glu  Ser Asp Thr 
    1070                 1075                 1080             


Gln Ser  Val Ser Gly His Gly  Gln Asp Gly Pro His  Gln Gln Ser 
    1085                 1090                 1095             


His Gln  Glu Ser Ala Arg Asp  Trp Ser Gly Gly Arg  Ser Gly Arg 
    1100                 1105                 1110             


Ser Gly  Ser Phe Ile Tyr Gln  Val Ser Thr His Glu  Gln Ser Glu 
    1115                 1120                 1125             


Ser Ala  His Gly Arg Thr Arg  Thr Ser Thr Gly Arg  Arg Gln Gly 
    1130                 1135                 1140             


Ser His  His Glu Gln Ala Arg  Asp Ser Ser Arg His  Ser Ala Ser 
    1145                 1150                 1155             


Gln Glu  Gly Gln Asp Thr Ile  Arg Ala His Pro Gly  Ser Arg Arg 
    1160                 1165                 1170             


Gly Gly  Arg Gln Gly Ser His  His Glu Gln Ser Val  Asp Arg Ser 
    1175                 1180                 1185             


Gly His  Ser Gly Ser His His  Ser His Thr Thr Ser  Gln Gly Arg 
    1190                 1195                 1200             


Ser Asp  Ala Ser His Gly Gln  Ser Gly Ser Arg Ser  Ala Ser Arg 
    1205                 1210                 1215             


Gln Thr  Arg Lys Asp Lys Gln  Ser Gly Asp Gly Ser  Arg His Ser 
    1220                 1225                 1230             


Gly Ser  Arg His His Glu Ala  Ala Ser Trp Ala Asp  Ser Ser Arg 
    1235                 1240                 1245             


His Ser  Gln Val Gly Gln Glu  Gln Ser Ser Gly Ser  Arg Thr Ser 
    1250                 1255                 1260             


Arg His  Gln Gly Ser Ser Val  Ser Gln Asp Ser Asp  Ser Glu Arg 
    1265                 1270                 1275             


His Ser  Asp Asp Ser Glu Arg  Leu Ser Gly Ser Ala  Ser Arg Asn 
    1280                 1285                 1290             


His His  Gly Ser Ser Arg Glu  Gln Ser Arg Asp Gly  Ser Arg His 
    1295                 1300                 1305             


Pro Gly  Phe His Gln Glu Asp  Arg Ala Ser His Gly  His Ser Ala 
    1310                 1315                 1320             


Asp Ser  Ser Arg Gln Ser Gly  Thr His His Thr Glu  Ser Ser Ser 
    1325                 1330                 1335             


His Gly  Gln Ala Val Ser Ser  His Glu Gln Ala Arg  Ser Ser Pro 
    1340                 1345                 1350             


Gly Glu  Arg His Gly Ser Arg  His Gln Gln Ser Ala  Asp Ser Ser 
    1355                 1360                 1365             


Arg His  Ser Gly Ile Gly His  Arg Gln Ala Ser Ser  Ala Val Arg 
    1370                 1375                 1380             


Asp Ser  Gly His Arg Gly Ser  Ser Gly Ser Gln Val  Thr Asn Ser 
    1385                 1390                 1395             


Glu Gly  His Ser Glu Asp Ser  Asp Thr Gln Ser Val  Ser Ala His 
    1400                 1405                 1410             


Gly Gln  Ala Gly Pro His Gln  Gln Ser His Lys Glu  Ser Ala Arg 
    1415                 1420                 1425             


Gly Gln  Ser Gly Glu Ser Ser  Gly Arg Ser Arg Ser  Phe Leu Tyr 
    1430                 1435                 1440             


Gln Val  Ser Ser His Glu Gln  Ser Glu Ser Thr His  Gly Gln Thr 
    1445                 1450                 1455             


Ala Pro  Ser Thr Gly Gly Arg  Gln Gly Ser Arg His  Glu Gln Ala 
    1460                 1465                 1470             


Arg Asn  Ser Ser Arg His Ser  Ala Ser Gln Asp Gly  Gln Asp Thr 
    1475                 1480                 1485             


Ile Arg  Gly His Pro Gly Ser  Ser Arg Gly Gly Arg  Gln Gly Ser 
    1490                 1495                 1500             


Tyr His  Glu Gln Ser Val Asp  Arg Ser Gly His Ser  Gly Tyr His 
    1505                 1510                 1515             


His Ser  His Thr Thr Pro Gln  Gly Arg Ser Asp Ala  Ser His Gly 
    1520                 1525                 1530             


Gln Ser  Gly Pro Arg Ser Ala  Ser Arg Gln Thr Arg  Asn Glu Glu 
    1535                 1540                 1545             


Gln Ser  Gly Asp Gly Ser Arg  His Ser Gly Ser Arg  His His Glu 
    1550                 1555                 1560             


Pro Ser  Thr Arg Ala Gly Ser  Ser Arg His Ser Gln  Val Gly Gln 
    1565                 1570                 1575             


Gly Glu  Ser Ala Gly Ser Lys  Thr Ser Arg Arg Gln  Gly Ser Ser 
    1580                 1585                 1590             


Val Ser  Gln Asp Arg Asp Ser  Glu Gly His Ser Glu  Asp Ser Glu 
    1595                 1600                 1605             


Arg Arg  Ser Glu Ser Ala Ser  Arg Asn His Tyr Gly  Ser Ala Arg 
    1610                 1615                 1620             


Glu Gln  Ser Arg His Gly Ser  Arg Asn Pro Arg Ser  His Gln Glu 
    1625                 1630                 1635             


Asp Arg  Ala Ser His Gly His  Ser Ala Glu Ser Ser  Arg Gln Ser 
    1640                 1645                 1650             


Gly Thr  Arg His Ala Glu Thr  Ser Ser Gly Gly Gln  Ala Ala Ser 
    1655                 1660                 1665             


Ser Gln  Glu Gln Ala Arg Ser  Ser Pro Gly Glu Arg  His Gly Ser 
    1670                 1675                 1680             


Arg His  Gln Gln Ser Ala Asp  Ser Ser Thr Asp Ser  Gly Thr Gly 
    1685                 1690                 1695             


Arg Arg  Gln Asp Ser Ser Val  Val Gly Asp Ser Gly  Asn Arg Gly 
    1700                 1705                 1710             


Ser Ser  Gly Ser Gln Ala Ser  Asp Ser Glu Gly His  Ser Glu Glu 
    1715                 1720                 1725             


Ser Asp  Thr Gln Ser Val Ser  Ala His Gly Gln Ala  Gly Pro His 
    1730                 1735                 1740             


Gln Gln  Ser His Gln Glu Ser  Thr Arg Gly Gln Ser  Gly Glu Arg 
    1745                 1750                 1755             


Ser Gly  Arg Ser Gly Ser Phe  Leu Tyr Gln Val Ser  Thr His Glu 
    1760                 1765                 1770             


Gln Ser  Glu Ser Ala His Gly  Arg Thr Gly Pro Ser  Thr Gly Gly 
    1775                 1780                 1785             


Arg Gln  Arg Ser Arg His Glu  Gln Ala Arg Asp Ser  Ser Arg His 
    1790                 1795                 1800             


Ser Ala  Ser Gln Glu Gly Gln  Asp Thr Ile Arg Gly  His Pro Gly 
    1805                 1810                 1815             


Ser Ser  Arg Gly Gly Arg Gln  Gly Ser His Tyr Glu  Gln Ser Val 
    1820                 1825                 1830             


Asp Ser  Ser Gly His Ser Gly  Ser His His Ser His  Thr Thr Ser 
    1835                 1840                 1845             


Gln Glu  Arg Ser Asp Val Ser  Arg Gly Gln Ser Gly  Ser Arg Ser 
    1850                 1855                 1860             


Val Ser  Arg Gln Thr Arg Asn  Glu Lys Gln Ser Gly  Asp Gly Ser 
    1865                 1870                 1875             


Arg His  Ser Gly Ser Arg His  His Glu Ala Ser Ser  Arg Ala Asp 
    1880                 1885                 1890             


Ser Ser  Arg His Ser Gln Val  Gly Gln Gly Gln Ser  Ser Gly Pro 
    1895                 1900                 1905             


Arg Thr  Ser Arg Asn Gln Gly  Ser Ser Val Ser Gln  Asp Ser Asp 
    1910                 1915                 1920             


Ser Gln  Gly His Ser Glu Asp  Ser Glu Arg Trp Ser  Gly Ser Ala 
    1925                 1930                 1935             


Ser Arg  Asn His Leu Gly Ser  Ala Trp Glu Gln Ser  Arg Asp Gly 
    1940                 1945                 1950             


Ser Arg  His Pro Gly Ser His  His Glu Asp Arg Ala  Gly His Gly 
    1955                 1960                 1965             


His Ser  Ala Asp Ser Ser Arg  Gln Ser Gly Thr Arg  His Thr Glu 
    1970                 1975                 1980             


Ser Ser  Ser Arg Gly Gln Ala  Ala Ser Ser His Glu  Gln Ala Arg 
    1985                 1990                 1995             


Ser Ser  Ala Gly Glu Arg His  Gly Ser His His Gln  Leu Gln Ser 
    2000                 2005                 2010             


Ala Asp  Ser Ser Arg His Ser  Gly Ile Gly His Gly  Gln Ala Ser 
    2015                 2020                 2025             


Ser Ala  Val Arg Asp Ser Gly  His Arg Gly Tyr Ser  Gly Ser Gln 
    2030                 2035                 2040             


Ala Ser  Asp Ser Glu Gly His  Ser Glu Asp Ser Asp  Thr Gln Ser 
    2045                 2050                 2055             


Val Ser  Ala Gln Gly Lys Ala  Gly Pro His Gln Gln  Ser His Lys 
    2060                 2065                 2070             


Glu Ser  Ala Arg Gly Gln Ser  Gly Glu Ser Ser Gly  Arg Ser Gly 
    2075                 2080                 2085             


Ser Phe  Leu Tyr Gln Val Ser  Thr His Glu Gln Ser  Glu Ser Thr 
    2090                 2095                 2100             


His Gly  Gln Ser Ala Pro Ser  Thr Gly Gly Arg Gln  Gly Ser His 
    2105                 2110                 2115             


Tyr Asp  Gln Ala Gln Asp Ser  Ser Arg His Ser Ala  Ser Gln Glu 
    2120                 2125                 2130             


Gly Gln  Asp Thr Ile Arg Gly  His Pro Gly Pro Ser  Arg Gly Gly 
    2135                 2140                 2145             


Arg Gln  Gly Ser His Gln Glu  Gln Ser Val Asp Arg  Ser Gly His 
    2150                 2155                 2160             


Ser Gly  Ser His His Ser His  Thr Thr Ser Gln Gly  Arg Ser Asp 
    2165                 2170                 2175             


Ala Ser  Arg Gly Gln Ser Gly  Ser Arg Ser Ala Ser  Arg Lys Thr 
    2180                 2185                 2190             


Tyr Asp  Lys Glu Gln Ser Gly  Asp Gly Ser Arg His  Ser Gly Ser 
    2195                 2200                 2205             


His His  His Glu Ala Ser Ser  Trp Ala Asp Ser Ser  Arg His Ser 
    2210                 2215                 2220             


Leu Val  Gly Gln Gly Gln Ser  Ser Gly Pro Arg Thr  Ser Arg Pro 
    2225                 2230                 2235             


Arg Gly  Ser Ser Val Ser Gln  Asp Ser Asp Ser Glu  Gly His Ser 
    2240                 2245                 2250             


Glu Asp  Ser Glu Arg Arg Ser  Gly Ser Ala Ser Arg  Asn His His 
    2255                 2260                 2265             


Gly Ser  Ala Gln Glu Gln Ser  Arg Asp Gly Ser Arg  His Pro Arg 
    2270                 2275                 2280             


Ser His  His Glu Asp Arg Ala  Gly His Gly His Ser  Ala Glu Ser 
    2285                 2290                 2295             


Ser Arg  Gln Ser Gly Thr His  His Ala Glu Asn Ser  Ser Gly Gly 
    2300                 2305                 2310             


Gln Ala  Ala Ser Ser His Glu  Gln Ala Arg Ser Ser  Ala Gly Glu 
    2315                 2320                 2325             


Arg His  Gly Ser His His Gln  Gln Ser Ala Asp Ser  Ser Arg His 
    2330                 2335                 2340             


Ser Gly  Ile Gly His Gly Gln  Ala Ser Ser Ala Val  Arg Asp Ser 
    2345                 2350                 2355             


Gly His  Arg Gly Ser Ser Gly  Ser Gln Ala Ser Asp  Ser Glu Gly 
    2360                 2365                 2370             


His Ser  Glu Asp Ser Asp Thr  Gln Ser Val Ser Ala  His Gly Gln 
    2375                 2380                 2385             


Ala Gly  Pro His Gln Gln Ser  His Gln Glu Ser Thr  Arg Gly Arg 
    2390                 2395                 2400             


Ser Ala  Gly Arg Ser Gly Arg  Ser Gly Ser Phe Leu  Tyr Gln Val 
    2405                 2410                 2415             


Ser Thr  His Glu Gln Ser Glu  Ser Ala His Gly Arg  Thr Gly Thr 
    2420                 2425                 2430             


Ser Thr  Gly Gly Arg Gln Gly  Ser His His Lys Gln  Ala Arg Asp 
    2435                 2440                 2445             


Ser Ser  Arg His Ser Thr Ser  Gln Glu Gly Gln Asp  Thr Ile His 
    2450                 2455                 2460             


Gly His  Pro Gly Ser Ser Ser  Gly Gly Arg Gln Gly  Ser His Tyr 
    2465                 2470                 2475             


Glu Gln  Leu Val Asp Arg Ser  Gly His Ser Gly Ser  His His Ser 
    2480                 2485                 2490             


His Thr  Thr Ser Gln Gly Arg  Ser Asp Ala Ser His  Gly His Ser 
    2495                 2500                 2505             


Gly Ser  Arg Ser Ala Ser Arg  Gln Thr Arg Asn Asp  Glu Gln Ser 
    2510                 2515                 2520             


Gly Asp  Gly Ser Arg His Ser  Gly Ser Arg His His  Glu Ala Ser 
    2525                 2530                 2535             


Ser Arg  Ala Asp Ser Ser Gly  His Ser Gln Val Gly  Gln Gly Gln 
    2540                 2545                 2550             


Ser Glu  Gly Pro Arg Thr Ser  Arg Asn Trp Gly Ser  Ser Phe Ser 
    2555                 2560                 2565             


Gln Asp  Ser Asp Ser Gln Gly  His Ser Glu Asp Ser  Glu Arg Trp 
    2570                 2575                 2580             


Ser Gly  Ser Ala Ser Arg Asn  His His Gly Ser Ala  Gln Glu Gln 
    2585                 2590                 2595             


Leu Arg  Asp Gly Ser Arg His  Pro Arg Ser His Gln  Glu Asp Arg 
    2600                 2605                 2610             


Ala Gly  His Gly His Ser Ala  Asp Ser Ser Arg Gln  Ser Gly Thr 
    2615                 2620                 2625             


Arg His  Thr Gln Thr Ser Ser  Gly Gly Gln Ala Ala  Ser Ser His 
    2630                 2635                 2640             


Glu Gln  Ala Arg Ser Ser Ala  Gly Glu Arg His Gly  Ser His His 
    2645                 2650                 2655             


Gln Gln  Ser Ala Asp Ser Ser  Arg His Ser Gly Ile  Gly His Gly 
    2660                 2665                 2670             


Gln Ala  Ser Ser Ala Val Arg  Asp Ser Gly His Arg  Gly Tyr Ser 
    2675                 2680                 2685             


Gly Ser  Gln Ala Ser Asp Asn  Glu Gly His Ser Glu  Asp Ser Asp 
    2690                 2695                 2700             


Thr Gln  Ser Val Ser Ala His  Gly Gln Ala Gly Ser  His Gln Gln 
    2705                 2710                 2715             


Ser His  Gln Glu Ser Ala Arg  Gly Arg Ser Gly Glu  Thr Ser Gly 
    2720                 2725                 2730             


His Ser  Gly Ser Phe Leu Tyr  Gln Val Ser Thr His  Glu Gln Ser 
    2735                 2740                 2745             


Glu Ser  Ser His Gly Trp Thr  Gly Pro Ser Thr Arg  Gly Arg Gln 
    2750                 2755                 2760             


Gly Ser  Arg His Glu Gln Ala  Gln Asp Ser Ser Arg  His Ser Ala 
    2765                 2770                 2775             


Ser Gln  Asp Gly Gln Asp Thr  Ile Arg Gly His Pro  Gly Ser Ser 
    2780                 2785                 2790             


Arg Gly  Gly Arg Gln Gly Tyr  His His Glu His Ser  Val Asp Ser 
    2795                 2800                 2805             


Ser Gly  His Ser Gly Ser His  His Ser His Thr Thr  Ser Gln Gly 
    2810                 2815                 2820             


Arg Ser  Asp Ala Ser Arg Gly  Gln Ser Gly Ser Arg  Ser Ala Ser 
    2825                 2830                 2835             


Arg Thr  Thr Arg Asn Glu Glu  Gln Ser Gly Asp Gly  Ser Arg His 
    2840                 2845                 2850             


Ser Gly  Ser Arg His His Glu  Ala Ser Thr His Ala  Asp Ile Ser 
    2855                 2860                 2865             


Arg His  Ser Gln Ala Val Gln  Gly Gln Ser Glu Gly  Ser Arg Arg 
    2870                 2875                 2880             


Ser Arg  Arg Gln Gly Ser Ser  Val Ser Gln Asp Ser  Asp Ser Glu 
    2885                 2890                 2895             


Gly His  Ser Glu Asp Ser Glu  Arg Trp Ser Gly Ser  Ala Ser Arg 
    2900                 2905                 2910             


Asn His  His Gly Ser Ala Gln  Glu Gln Leu Arg Asp  Gly Ser Arg 
    2915                 2920                 2925             


His Pro  Arg Ser His Gln Glu  Asp Arg Ala Gly His  Gly His Ser 
    2930                 2935                 2940             


Ala Asp  Ser Ser Arg Gln Ser  Gly Thr Arg His Thr  Gln Thr Ser 
    2945                 2950                 2955             


Ser Gly  Gly Gln Ala Ala Ser  Ser His Glu Gln Ala  Arg Ser Ser 
    2960                 2965                 2970             


Ala Gly  Glu Arg His Gly Ser  His His Gln Gln Ser  Ala Asp Ser 
    2975                 2980                 2985             


Ser Arg  His Ser Gly Ile Gly  His Gly Gln Ala Ser  Ser Ala Val 
    2990                 2995                 3000             


Arg Asp  Ser Gly His Arg Gly  Tyr Ser Gly Ser Gln  Ala Ser Asp 
    3005                 3010                 3015             


Asn Glu  Gly His Ser Glu Asp  Ser Asp Thr Gln Ser  Val Ser Ala 
    3020                 3025                 3030             


His Gly  Gln Ala Gly Ser His  Gln Gln Ser His Gln  Glu Ser Ala 
    3035                 3040                 3045             


Arg Gly  Arg Ser Gly Glu Thr  Ser Gly His Ser Gly  Ser Phe Leu 
    3050                 3055                 3060             


Tyr Gln  Val Ser Thr His Glu  Gln Ser Glu Ser Ser  His Gly Trp 
    3065                 3070                 3075             


Thr Gly  Pro Ser Thr Arg Gly  Arg Gln Gly Ser Arg  His Glu Gln 
    3080                 3085                 3090             


Ala Gln  Asp Ser Ser Arg His  Ser Ala Ser Gln Tyr  Gly Gln Asp 
    3095                 3100                 3105             


Thr Ile  Arg Gly His Pro Gly  Ser Ser Arg Gly Gly  Arg Gln Gly 
    3110                 3115                 3120             


Tyr His  His Glu His Ser Val  Asp Ser Ser Gly His  Ser Gly Ser 
    3125                 3130                 3135             


His His  Ser His Thr Thr Ser  Gln Gly Arg Ser Asp  Ala Ser Arg 
    3140                 3145                 3150             


Gly Gln  Ser Gly Ser Arg Ser  Ala Ser Arg Thr Thr  Arg Asn Glu 
    3155                 3160                 3165             


Glu Gln  Ser Gly Asp Ser Ser  Arg His Ser Val Ser  Arg His His 
    3170                 3175                 3180             


Glu Ala  Ser Thr His Ala Asp  Ile Ser Arg His Ser  Gln Ala Val 
    3185                 3190                 3195             


Gln Gly  Gln Ser Glu Gly Ser  Arg Arg Ser Arg Arg  Gln Gly Ser 
    3200                 3205                 3210             


Ser Val  Ser Gln Asp Ser Asp  Ser Glu Gly His Ser  Glu Asp Ser 
    3215                 3220                 3225             


Glu Arg  Trp Ser Gly Ser Ala  Ser Arg Asn His Arg  Gly Ser Val 
    3230                 3235                 3240             


Gln Glu  Gln Ser Arg His Gly  Ser Arg His Pro Arg  Ser His His 
    3245                 3250                 3255             


Glu Asp  Arg Ala Gly His Gly  His Ser Ala Asp Arg  Ser Arg Gln 
    3260                 3265                 3270             


Ser Gly  Thr Arg His Ala Glu  Thr Ser Ser Gly Gly  Gln Ala Ala 
    3275                 3280                 3285             


Ser Ser  His Glu Gln Ala Arg  Ser Ser Pro Gly Glu  Arg His Gly 
    3290                 3295                 3300             


Ser Arg  His Gln Gln Ser Ala  Asp Ser Ser Arg His  Ser Gly Ile 
    3305                 3310                 3315             


Pro Arg  Gly Gln Ala Ser Ser  Ala Val Arg Asp Ser  Arg His Trp 
    3320                 3325                 3330             


Gly Ser  Ser Gly Ser Gln Ala  Ser Asp Ser Glu Gly  His Ser Glu 
    3335                 3340                 3345             


Glu Ser  Asp Thr Gln Ser Val  Ser Gly His Gly Gln  Ala Gly Pro 
    3350                 3355                 3360             


His Gln  Gln Ser His Gln Glu  Ser Ala Arg Asp Arg  Ser Gly Gly 
    3365                 3370                 3375             


Arg Ser  Gly Arg Ser Gly Ser  Phe Leu Tyr Gln Val  Ser Thr His 
    3380                 3385                 3390             


Glu Gln  Ser Glu Ser Ala His  Gly Arg Thr Arg Thr  Ser Thr Gly 
    3395                 3400                 3405             


Arg Arg  Gln Gly Ser His His  Glu Gln Ala Arg Asp  Ser Ser Arg 
    3410                 3415                 3420             


His Ser  Ala Ser Gln Glu Gly  Gln Asp Thr Ile Arg  Gly His Pro 
    3425                 3430                 3435             


Gly Ser  Ser Arg Arg Gly Arg  Gln Gly Ser His Tyr  Glu Gln Ser 
    3440                 3445                 3450             


Val Asp  Arg Ser Gly His Ser  Gly Ser His His Ser  His Thr Thr 
    3455                 3460                 3465             


Ser Gln  Gly Arg Ser Asp Ala  Ser Arg Gly Gln Ser  Gly Ser Arg 
    3470                 3475                 3480             


Ser Ala  Ser Arg Gln Thr Arg  Asn Asp Glu Gln Ser  Gly Asp Gly 
    3485                 3490                 3495             


Ser Arg  His Ser Trp Ser His  His His Glu Ala Ser  Thr Gln Ala 
    3500                 3505                 3510             


Asp Ser  Ser Arg His Ser Gln  Ser Gly Gln Gly Gln  Ser Ala Gly 
    3515                 3520                 3525             


Pro Arg  Thr Ser Arg Asn Gln  Gly Ser Ser Val Ser  Gln Asp Ser 
    3530                 3535                 3540             


Asp Ser  Gln Gly His Ser Glu  Asp Ser Glu Arg Trp  Ser Gly Ser 
    3545                 3550                 3555             


Ala Ser  Arg Asn His Arg Gly  Ser Ala Gln Glu Gln  Ser Arg Asp 
    3560                 3565                 3570             


Gly Ser  Arg His Pro Thr Ser  His His Glu Asp Arg  Ala Gly His 
    3575                 3580                 3585             


Gly His  Ser Ala Glu Ser Ser  Arg Gln Ser Gly Thr  His His Ala 
    3590                 3595                 3600             


Glu Asn  Ser Ser Gly Gly Gln  Ala Ala Ser Ser His  Glu Gln Ala 
    3605                 3610                 3615             


Arg Ser  Ser Ala Gly Glu Arg  His Gly Ser His His  Gln Gln Ser 
    3620                 3625                 3630             


Ala Asp  Ser Ser Arg His Ser  Gly Ile Gly His Gly  Gln Ala Ser 
    3635                 3640                 3645             


Ser Ala  Val Arg Asp Ser Gly  His Arg Gly Ser Ser  Gly Ser Gln 
    3650                 3655                 3660             


Ala Ser  Asp Ser Glu Gly His  Ser Glu Asp Ser Asp  Thr Gln Ser 
    3665                 3670                 3675             


Val Ser  Ala His Gly Gln Ala  Gly Pro His Gln Gln  Ser His Gln 
    3680                 3685                 3690             


Glu Ser  Thr Arg Gly Arg Ser  Ala Gly Arg Ser Gly  Arg Ser Gly 
    3695                 3700                 3705             


Ser Phe  Leu Tyr Gln Val Ser  Thr His Glu Gln Ser  Glu Ser Ala 
    3710                 3715                 3720             


His Gly  Arg Ala Gly Pro Ser  Thr Gly Gly Arg Gln  Gly Ser Arg 
    3725                 3730                 3735             


His Glu  Gln Ala Arg Asp Ser  Ser Arg His Ser Ala  Ser Gln Glu 
    3740                 3745                 3750             


Gly Gln  Asp Thr Ile Arg Gly  His Pro Gly Ser Arg  Arg Gly Gly 
    3755                 3760                 3765             


Arg Gln  Gly Ser Tyr His Glu  Gln Ser Val Asp Arg  Ser Gly His 
    3770                 3775                 3780             


Ser Gly  Ser His His Ser His  Thr Thr Ser Gln Gly  Arg Ser Asp 
    3785                 3790                 3795             


Ala Ser  His Gly Gln Ser Gly  Ser Arg Ser Ala Ser  Arg Glu Thr 
    3800                 3805                 3810             


Arg Asn  Glu Glu Gln Ser Gly  Asp Gly Ser Arg His  Ser Gly Ser 
    3815                 3820                 3825             


Arg His  His Glu Ala Ser Thr  Gln Ala Asp Ser Ser  Arg His Ser 
    3830                 3835                 3840             


Gln Ser  Gly Gln Gly Glu Ser  Ala Gly Ser Arg Arg  Ser Arg Arg 
    3845                 3850                 3855             


Gln Gly  Ser Ser Val Ser Gln  Asp Ser Asp Ser Glu  Ala Tyr Pro 
    3860                 3865                 3870             


Glu Asp  Ser Glu Arg Arg Ser  Glu Ser Ala Ser Arg  Asn His His 
    3875                 3880                 3885             


Gly Ser  Ser Arg Glu Gln Ser  Arg Asp Gly Ser Arg  His Pro Gly 
    3890                 3895                 3900             


Ser Ser  His Arg Asp Thr Ala  Ser His Val Gln Ser  Ser Pro Val 
    3905                 3910                 3915             


Gln Ser  Asp Ser Ser Thr Ala  Lys Glu His Gly His  Phe Ser Ser 
    3920                 3925                 3930             


Leu Ser  Gln Asp Ser Ala Tyr  His Ser Gly Ile Gln  Ser Arg Gly 
    3935                 3940                 3945             


Ser Pro  His Ser Ser Ser Ser  Tyr His Tyr Gln Ser  Glu Gly Thr 
    3950                 3955                 3960             


Glu Arg  Gln Lys Gly Gln Ser  Gly Leu Val Trp Arg  His Gly Ser 
    3965                 3970                 3975             


Tyr Gly  Ser Ala Asp Tyr Asp  Tyr Gly Glu Ser Gly  Phe Arg His 
    3980                 3985                 3990             


Ser Gln  His Gly Ser Val Ser  Tyr Asn Ser Asn Pro  Val Val Phe 
    3995                 4000                 4005             


Lys Glu  Arg Ser Asp Ile Cys  Lys Ala Ser Ala Phe  Gly Lys Asp 
    4010                 4015                 4020             


His Pro  Arg Tyr Tyr Ala Thr  Tyr Ile Asn Lys Asp  Pro Gly Leu 
    4025                 4030                 4035             


Cys Gly  His Ser Ser Asp Ile  Ser Lys Gln Leu Gly  Phe Ser Gln 
    4040                 4045                 4050             


Ser Gln  Arg Tyr Tyr Tyr Tyr  Glu 
    4055                 4060     


<210> 12
<211> 4384
<212> PRT
<213> Mus musculus


<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1048)..(1048)
<223> Any amino acid

<400> 12
Met Ser Ala Leu Leu Glu Ser Ile Thr Ser Met Ile Glu Ile Phe Gln 
1               5                   10                  15      


Gln Tyr Ser Thr Ser Asp Lys Glu Glu Glu Thr Leu Ser Lys Glu Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Gly Gln Leu Gln Ala Val Leu Lys Asn Pro 
        35                  40                  45              


Asp Asp Gln Asp Ile Ala Glu Val Phe Met Gln Met Leu Asp Val Asp 
    50                  55                  60                  


His Asp Asp Lys Leu Asp Phe Ala Glu Tyr Leu Leu Leu Val Leu Lys 
65                  70                  75                  80  


Leu Ala Lys Ala Tyr Tyr Glu Ala Ser Lys Asn Glu Ser Phe Gln Thr 
                85                  90                  95      


His Gly Ser Asn Gly Arg Ser Lys Thr Asp Tyr Lys Gly Leu Glu Glu 
            100                 105                 110         


Glu Gly Glu Glu Gly Asn Lys Gln Asn Leu Arg Arg Arg His Gly Gly 
        115                 120                 125             


Thr Asp Gly Lys Arg Lys Ser Asp Arg Thr Arg Ser Pro Asn Gly Lys 
    130                 135                 140                 


Arg Gly Lys Arg Gln Glu Ser Arg Cys Arg Ser Glu Gly Lys Asp Lys 
145                 150                 155                 160 


His Arg Arg Glu Pro Glu Lys His Arg His Gln Gln Asp Ser Lys Arg 
                165                 170                 175     


Lys Gln Arg His Gly Ser Gly Ser Thr Glu Arg Lys Asp Asn Arg Asn 
            180                 185                 190         


Lys Lys Asn Arg Gln Ser Lys Glu Arg Asn Tyr Asp Glu Ile Tyr Asp 
        195                 200                 205             


Asn Gly Lys Tyr Asn Glu Asp Trp Glu Ala Ser Tyr Asn Asn Cys Tyr 
    210                 215                 220                 


Tyr Lys Thr Gln Asn Thr Thr Leu Asp Gln Arg Glu Gly Asn Arg Arg 
225                 230                 235                 240 


Pro Arg Ala Asp Ser Gln Lys Glu Pro Gln Ser Ser His Gly Gln Ala 
                245                 250                 255     


Asp Asn Ser Asp Ser Glu Gly Gly Arg Gln Gln Ser His Ser Lys Pro 
            260                 265                 270         


Ser Pro Val Arg Ala Asp Gln Arg Arg Ser Arg Ala Gly Gln Ala Gly 
        275                 280                 285             


Ser Ser Lys Val Ser Ala Arg Ser Gly Ser Gly Gly Arg Gly Gln Ser 
    290                 295                 300                 


Pro Asp Gly Ser Gly Arg Ser Ser Asn Arg Arg Asp Arg Pro Arg Gln 
305                 310                 315                 320 


Pro Ser Pro Ser Gln Ser Ser Asp Ser Gln Val His Ser Gly Val Gln 
                325                 330                 335     


Val Glu Gly Arg Arg Gly Gln Ser Ser Ser Ala Asn Arg Arg Ala Gly 
            340                 345                 350         


Ser Ser Ser Gly Ser Gly Val Gln Gly Ala Ser Ala Gly Gly Leu Ala 
        355                 360                 365             


Ala Asp Ala Ser Arg Arg Ser Gly Ala Arg Gln Gly Gln Ala Ser Ala 
    370                 375                 380                 


Gln Gly Arg Ala Gly Ser Gln Gly Gln Ala Gln Gly Arg Val Gly Ser 
385                 390                 395                 400 


Ser Ala Asp Arg Gln Gly Arg Arg Gly Val Ser Glu Ser Gln Ala Ser 
                405                 410                 415     


Asp Ser Glu Gly His Ser Asp Phe Ser Glu Gly Gln Ala Val Gly Ala 
            420                 425                 430         


His Arg Gln Ser Gly Ala Gly Gln Arg His Glu Gln Arg Ser Ser Arg 
        435                 440                 445             


Gly Gln His Gly Ser Arg Tyr Tyr Tyr Glu Gln Glu His Ser Glu Glu 
    450                 455                 460                 


Glu Ser Asp Ser Gln His Gln His Gly His Gln His Glu Gln Gln Arg 
465                 470                 475                 480 


Gly His Gln His Gln His Glu His Glu Gln Pro Glu Ser Gly His Arg 
                485                 490                 495     


Gln Gln Gln Ser Ser Gly Arg Gly His Gln Gly Ala His Gln Glu Gln 
            500                 505                 510         


Gly Arg Asp Ser Ala Arg Ser Arg Gly Ser Asn Gln Gly His Ser Ser 
        515                 520                 525             


Ser Arg His Gln Ala Asp Ser Pro Arg Val Ser Ala Arg Ser Gly Ser 
    530                 535                 540                 


Gly Gly Arg Gly Gln Ser Pro Asp Ala Ser Gly Arg Ser Ser Asn Arg 
545                 550                 555                 560 


Arg Asp Arg Pro Arg Gln Pro Ser Pro Ser Gln Ser Ser Asp Ser Gln 
                565                 570                 575     


Val His Ser Gly Val Gln Val Glu Gly Arg Arg Gly Gln Ser Ser Ser 
            580                 585                 590         


Ala Asn Arg Arg Ala Gly Ser Ser Ser Gly Ser Gly Val Gln Gly Ala 
        595                 600                 605             


Ser Ala Gly Gly Leu Ala Ala Asp Ala Ser Arg Arg Ser Gly Ala Leu 
    610                 615                 620                 


Gln Gly Gln Ala Ser Ala Gln Gly Arg Ala Gly Ser Gln Gly Gln Ala 
625                 630                 635                 640 


Gln Gly Arg Val Gly Ser Ser Ala Asp Arg Gln Gly Arg Arg Gly Val 
                645                 650                 655     


Ser Glu Ser Gln Ala Ser Asp Ser Glu Gly His Ser Asp Phe Ser Glu 
            660                 665                 670         


Gly Gln Ala Val Gly Ala His Arg Gln Ser Gly Ala Gly Gln Arg His 
        675                 680                 685             


Glu Gln Arg Ser Ser Arg Gly Gln His Gly Ser Gly Tyr Tyr Tyr Glu 
    690                 695                 700                 


Gln Glu His Ser Glu Glu Glu Ser Asp Ser Gln His Gln His Gly His 
705                 710                 715                 720 


Gln His Glu Gln Gln Arg Gly His Gln His Gln His Gln His Gln His 
                725                 730                 735     


Glu His Glu Gln Pro Glu Ser Gly His Arg Gln Gln Gln Ser Ser Gly 
            740                 745                 750         


Arg Gly His Gln Gly Ala His Gln Glu Gln Gly Arg Asp Ser Ala Arg 
        755                 760                 765             


Ser Arg Gly Ser Asn Gln Gly His Ser Ser Ser Arg His Gln Ala Asp 
    770                 775                 780                 


Ser Pro Arg Val Ser Ala Arg Ser Gly Ser Gly Gly Arg Gly Gln Ser 
785                 790                 795                 800 


Pro Asp Ala Ser Gly Arg Ser Ser Asn Arg Arg Asp Arg Pro Arg Gln 
                805                 810                 815     


Pro Ser Pro Ser Gln Ser Ser Asp Ser Gln Val His Ser Gly Val Gln 
            820                 825                 830         


Val Glu Gly Arg Arg Gly Gln Ser Ser Ser Ala Asn Arg Arg Ala Gly 
        835                 840                 845             


Ser Ser Ser Gly Ser Gly Val Gln Gly Thr Ser Ala Gly Gly Leu Ala 
    850                 855                 860                 


Ala Asp Ala Ser Arg Arg Ser Gly Ala Arg Gln Gly Gln Ala Ser Ala 
865                 870                 875                 880 


Gln Gly Arg Ala Gly Ser Gln Gly Gln Ala Gln Gly Arg Val Gly Ser 
                885                 890                 895     


Ser Ala Asp Arg Gln Gly Arg Arg Gly Val Ser Glu Ser Gln Ala Ser 
            900                 905                 910         


Asp Ser Glu Gly His Ser Asp Phe Ser Glu Gly Gln Ala Val Gly Ala 
        915                 920                 925             


His Arg Gln Ser Gly Ala Gly Gln Arg His Glu Gln Arg Ser Ser Arg 
    930                 935                 940                 


Gly Gln His Gly Ser Gly Tyr Tyr Tyr Glu Gln Glu His Ser Glu Glu 
945                 950                 955                 960 


Glu Ser Asp Ser Gln His Gln His Gly His Gln His Glu Gln Gln Arg 
                965                 970                 975     


Gly His Gln His Gln His Gln His Gln His Glu His Glu Gln Pro Glu 
            980                 985                 990         


Ser Gly His Arg Gln Gln Gln Ser  Ser Gly Arg Gly Asn  Gln Gly Ala 
        995                 1000                 1005             


His Gln  Lys Gln Gly Arg Asp  Ser Ala Arg Ser Arg  Gly Ser Asn 
    1010                 1015                 1020             


Gln Gly  His Ser Ser Ser Arg  His Gln Ala Asp Ser  Pro Arg Val 
    1025                 1030                 1035             


Ser Ala  Arg Ser Gly Ser Xaa  Gly Arg Xaa Gln Ser  Pro Asp Ala 
    1040                 1045                 1050             


Ser Gly  Arg Asn Ser Thr Lys  Arg Asp Arg Pro Arg  Gln Pro Ser 
    1055                 1060                 1065             


Pro Ser  Gln Ser Ser Asp Ser  His Val His Ser Gly  Lys Ala Gly 
    1070                 1075                 1080             


Ser Ile  Ser Gly Ser Gly Val  Gln Gly Ala Ser Ala  Gly Gly Leu 
    1085                 1090                 1095             


Ala Ala  Asp Ala Ser Arg Arg  Ser Gly Ala Arg Gln  Gly Gln Ala 
    1100                 1105                 1110             


Ser Ala  Gln Gly Arg Ala Gly  Ser Gln Gly Gln Ala  Gln Gly Arg 
    1115                 1120                 1125             


Val Gly  Ser Ser Ala Asp Arg  Gln Gly Arg Arg Gly  Val Ser Glu 
    1130                 1135                 1140             


Ser Gln  Ala Ser Asp Ser Glu  Gly His Ser Asp Phe  Ser Glu Gly 
    1145                 1150                 1155             


Gln Ala  Val Gly Ala His Arg  Gln Ser Gly Ala Gly  Gln Arg His 
    1160                 1165                 1170             


Glu Gln  Arg Ser Ser Arg Gly  Gln His Gly Ser Arg  Tyr Tyr Tyr 
    1175                 1180                 1185             


Glu Gln  Glu His Ser Glu Glu  Glu Ser Asp Ser Gln  His Gln His 
    1190                 1195                 1200             


Gly His  Gln His Glu Gln Gln  Arg Gly His Gln His  Gln His Glu 
    1205                 1210                 1215             


His Glu  Gln Pro Glu Ser Gly  His Arg Gln Gln Gln  Ser Ser Gly 
    1220                 1225                 1230             


Arg Gly  His Gln Gly Ala His  Gln Glu Gln Gly Arg  Asp Ser Ala 
    1235                 1240                 1245             


Arg Ser  Arg Gly Ser Asn Gln  Gly His Ser Ser Ser  Arg His Gln 
    1250                 1255                 1260             


Ala Asp  Ser Pro Arg Val Ser  Ala Arg Ser Gly Ser  Gly Gly Arg 
    1265                 1270                 1275             


Gly Gln  Ser Pro Asp Ala Ser  Gly Arg Ser Ser Asn  Arg Arg Asp 
    1280                 1285                 1290             


Arg Pro  Arg Gln Pro Ser Pro  Ser Gln Ser Ser Asp  Ser Gln Val 
    1295                 1300                 1305             


His Ser  Gly Val Gln Val Glu  Gly Arg Arg Gly Gln  Ser Ser Ser 
    1310                 1315                 1320             


Ala Asn  Arg Arg Ala Gly Ser  Ser Ser Gly Ser Gly  Val Gln Gly 
    1325                 1330                 1335             


Ala Ser  Ala Gly Gly Leu Ala  Ala Asp Ala Ser Arg  Arg Ser Gly 
    1340                 1345                 1350             


Ala Arg  Gln Gly Gln Ala Ser  Ala Gln Gly Arg Ala  Gly Ser Gln 
    1355                 1360                 1365             


Gly Gln  Ala Gln Gly Arg Ile  Gly Ser Ser Ala Asp  Arg Gln Gly 
    1370                 1375                 1380             


Arg Arg  Gly Val Ser Glu Ser  Gln Ala Ser Asp Ser  Glu Gly His 
    1385                 1390                 1395             


Ser Asp  Phe Ser Glu Gly Gln  Ala Val Gly Ala His  Arg Gln Ser 
    1400                 1405                 1410             


Glu Ala  Gly Gln Arg His Glu  Gln Arg Ser Ser Arg  Gly Gln His 
    1415                 1420                 1425             


Gly Ser  Gly Tyr Tyr Tyr Glu  Gln Glu His Ser Glu  Glu Glu Ser 
    1430                 1435                 1440             


Asp Ser  Gln His Gln His Gly  His Gln His Glu Gln  Gln Arg Gly 
    1445                 1450                 1455             


Thr Gln  His Gln His Glu His  Gln Gln Pro Glu Ser  Gly His Arg 
    1460                 1465                 1470             


Gln Gln  Gln Ser Ser Gly Arg  Gly His Gln Gly Thr  His Gln Glu 
    1475                 1480                 1485             


Gln Gly  Arg Asp Ser Ala Arg  Ser Arg Gly Ser Asn  Gln Gly His 
    1490                 1495                 1500             


Ser Ser  Ser Arg His Gln Ala  Asp Ser Pro Arg Val  Ser Ala Arg 
    1505                 1510                 1515             


Ser Gly  Ser Gly Gly Arg Gly  Gln Ser Pro Asp Ala  Ser Gly Arg 
    1520                 1525                 1530             


Ser Ser  Asn Arg Arg Asp Arg  Pro Arg Gln Pro Ser  Pro Ser Gln 
    1535                 1540                 1545             


Ser Ser  Asp Ser Gln Val His  Ser Gly Val Gln Val  Glu Gly Arg 
    1550                 1555                 1560             


Arg Arg  Gln Ser Ser Ser Ala  Asn Arg Arg Ala Gly  Ser Ser Ser 
    1565                 1570                 1575             


Gly Ser  Gly Val Gln Gly Ala  Ser Ala Gly Gly Leu  Ala Ala Asp 
    1580                 1585                 1590             


Ala Ser  Arg Arg Ser Gly Ala  Arg Gln Gly Gln Ala  Ser Ala Gln 
    1595                 1600                 1605             


Gly Arg  Ala Gly Ser Gln Gly  Gln Ala Gln Gly Arg  Val Gly Ser 
    1610                 1615                 1620             


Ser Ala  Asp Arg Gln Gly Arg  Arg Gly Val Ser Glu  Ser Gln Ala 
    1625                 1630                 1635             


Ser Asp  Ser Glu Gly His Ser  Asp Phe Ser Glu Gly  Gln Ala Val 
    1640                 1645                 1650             


Gly Ala  His Arg Gln Ser Gly  Ala Gly Gln Arg His  Glu Gln Arg 
    1655                 1660                 1665             


Ser Ser  Arg Gly Gln His Gly  Ser Gly Phe Tyr Pro  Val Tyr Tyr 
    1670                 1675                 1680             


Tyr Tyr  Glu Gln Glu His Ser  Glu Glu Glu Ser Asp  Ser Gln His 
    1685                 1690                 1695             


Gln His  Gly His Gln His Glu  Gln Gln Arg Gly His  Gln His Gln 
    1700                 1705                 1710             


His Gln  His Glu His Glu Gln  Pro Glu Ser Gly His  Arg Gln Gln 
    1715                 1720                 1725             


Gln Ser  Ser Gly Arg Gly His  Gln Gly Ala His Gln  Glu Gln Gly 
    1730                 1735                 1740             


Arg Asp  Ser Ala Arg Ser Arg  Gly Ser Asn Gln Gly  His Ser Ser 
    1745                 1750                 1755             


Ser Arg  His Gln Ala Asp Ser  Pro Arg Val Ser Ala  Arg Ser Gly 
    1760                 1765                 1770             


Ser Gly  Gly Arg Gly Gln Ser  Pro Asp Ala Ser Gly  Arg Ser Ser 
    1775                 1780                 1785             


Asn Arg  Arg Asp Arg Pro Arg  Gln Pro Ser Pro Ser  Gln Ser Ser 
    1790                 1795                 1800             


Asp Ser  Gln Val His Ser Gly  Val Gln Val Glu Gly  Arg Arg Gly 
    1805                 1810                 1815             


Gln Ser  Ser Ser Ala Asn Arg  Arg Ala Gly Ser Ser  Ser Gly Ser 
    1820                 1825                 1830             


Gly Val  Gln Gly Ala Ser Ala  Gly Gly Leu Ala Ala  Asp Ala Ser 
    1835                 1840                 1845             


Arg Arg  Ser Gly Ala Leu Gln  Gly Gln Ala Ser Ala  Gln Gly Arg 
    1850                 1855                 1860             


Ala Gly  Ser Gln Gly Gln Ala  Gln Gly Arg Val Gly  Ser Ser Ala 
    1865                 1870                 1875             


Asp Arg  Gln Gly Arg Arg Gly  Val Ser Gly Ser Gln  Ala Ser Asp 
    1880                 1885                 1890             


Ser Glu  Gly His Ser Asp Phe  Ser Glu Gly Gln Ala  Val Gly Ala 
    1895                 1900                 1905             


His Arg  Gln Ser Gly Ala Gly  Gln Arg His Glu Gln  Arg Ser Ser 
    1910                 1915                 1920             


Arg Gly  Gln His Gly Ser Gly  Tyr Tyr Tyr Glu Gln  Glu His Ser 
    1925                 1930                 1935             


Glu Glu  Glu Ser Asp Ser Gln  His Gln His Gly His  Gln His Glu 
    1940                 1945                 1950             


Gln Gln  Arg Gly His Gln His  Gln His Gln His Gln  His Glu His 
    1955                 1960                 1965             


Glu Gln  Pro Glu Ser Gly His  Arg Gln Gln Gln Phe  Ser Gly Arg 
    1970                 1975                 1980             


Gly His  Gln Gly Ala His Gln  Glu Gln Gly Arg Asp  Ser Ala Arg 
    1985                 1990                 1995             


Ser Arg  Gly Ser Asn Gln Gly  His Ser Ser Ser Arg  His Gln Ala 
    2000                 2005                 2010             


Asp Ser  Pro Arg Val Ser Ala  Arg Ser Gly Ser Gly  Gly Arg Gly 
    2015                 2020                 2025             


Gln Ser  Pro Asp Ala Ser Gly  Arg Ser Ser Asn Arg  Arg Asp Arg 
    2030                 2035                 2040             


Pro Arg  Gln Pro Ser Pro Ser  Gln Ser Ser Asp Ser  Gln Val His 
    2045                 2050                 2055             


Ser Gly  Val Gln Val Glu Gly  Arg Arg Gly Gln Ser  Ser Ser Ala 
    2060                 2065                 2070             


Asn Arg  Arg Ala Gly Ser Ser  Ser Gly Ser Gly Val  Gln Gly Ala 
    2075                 2080                 2085             


Ser Ala  Gly Gly Leu Ala Ala  Asp Ala Ser Arg Arg  Ser Gly Ala 
    2090                 2095                 2100             


Arg Gln  Gly Gln Ala Ser Ala  Gln Gly Arg Ala Gly  Ser Gln Gly 
    2105                 2110                 2115             


Gln Ala  Gln Gly Arg Val Gly  Ser Ser Ala Asp Arg  Gln Gly Arg 
    2120                 2125                 2130             


Arg Gly  Val Ser Glu Ser Gln  Ala Ser Asp Ser Glu  Gly His Ser 
    2135                 2140                 2145             


Asp Phe  Ser Glu Gly Gln Ala  Val Gly Ala His Arg  Gln Ser Gly 
    2150                 2155                 2160             


Ala Gly  Gln Arg His Glu Gln  Arg Ser Ser Arg Gly  Gln His Gly 
    2165                 2170                 2175             


Ser Gly  Phe Tyr Pro Val Tyr  Tyr Tyr Tyr Glu Gln  Glu His Ser 
    2180                 2185                 2190             


Glu Glu  Glu Ser Asp Ser Gln  His Gln His Gly His  Gln His Glu 
    2195                 2200                 2205             


Gln Gln  Arg Gly His Gln His  Gln His Gln His Gln  His Glu His 
    2210                 2215                 2220             


Glu Gln  Pro Glu Ser Gly His  Arg Gln Gln Gln Ser  Ser Gly Arg 
    2225                 2230                 2235             


Gly His  Gln Gly Ala His Gln  Glu Gln Gly Arg Asp  Ser Ala Arg 
    2240                 2245                 2250             


Ser Arg  Gly Ser Asn Gln Gly  His Ser Ser Ser Arg  His Gln Ala 
    2255                 2260                 2265             


Asp Ser  Pro Arg Val Ser Ala  Arg Ser Gly Ser Gly  Gly Arg Gly 
    2270                 2275                 2280             


Gln Ser  Pro Asp Ala Ser Gly  Arg Ser Ser Asn Arg  Arg Asp Arg 
    2285                 2290                 2295             


Pro Arg  Gln Pro Ser Pro Ser  Gln Ser Ser Asp Ser  Gln Val His 
    2300                 2305                 2310             


Ser Gly  Val Gln Val Glu Gly  Arg Arg Gly Gln Ser  Ser Ser Ala 
    2315                 2320                 2325             


Asn Arg  Arg Ala Gly Ser Ser  Ser Gly Ser Gly Val  Gln Gly Ala 
    2330                 2335                 2340             


Ser Ala  Gly Gly Leu Ala Ala  Asp Ala Ser Arg Arg  Ser Gly Ala 
    2345                 2350                 2355             


Arg Gln  Gly Gln Ala Ser Ala  Gln Gly Arg Ala Gly  Ser Gln Gly 
    2360                 2365                 2370             


Gln Ala  Gln Gly Arg Val Gly  Ser Ser Ala Asp Arg  Gln Gly Arg 
    2375                 2380                 2385             


Arg Gly  Val Ser Glu Ser Gln  Ala Ser Asp Ser Glu  Gly His Ser 
    2390                 2395                 2400             


Asp Phe  Ser Glu Gly Gln Ala  Val Gly Ala His Arg  Gln Ser Gly 
    2405                 2410                 2415             


Ala Gly  Gln Arg His Glu Gln  Arg Ser Ser Arg Gly  Gln His Gly 
    2420                 2425                 2430             


Ser Gly  Tyr Tyr Tyr Glu Gln  Glu His Ser Glu Glu  Glu Ser Asp 
    2435                 2440                 2445             


Ser Gln  His Gln His Gly His  Gln His Glu Gln Gln  Arg Gly His 
    2450                 2455                 2460             


Gln His  Gln His Gln His Gln  His Glu His Glu Gln  Pro Glu Ser 
    2465                 2470                 2475             


Gly His  Arg Gln Gln Gln Ser  Ser Gly Arg Gly His  Gln Gly Ala 
    2480                 2485                 2490             


His Gln  Glu Gln Gly Arg Asp  Ser Ala Arg Ser Arg  Gly Ser Asn 
    2495                 2500                 2505             


Gln Gly  His Ser Ser Ser Arg  His Gln Ala Asp Ser  Pro Arg Val 
    2510                 2515                 2520             


Ser Ala  Arg Ser Gly Ser Gly  Gly Arg Gly Gln Ser  Pro Asp Ala 
    2525                 2530                 2535             


Ser Gly  Arg Ser Ser Asn Arg  Arg Asp Arg Pro Arg  Gln Pro Ser 
    2540                 2545                 2550             


Pro Ser  Gln Ser Ser Asp Ser  Gln Val His Ser Gly  Val Gln Val 
    2555                 2560                 2565             


Glu Gly  Arg Arg Gly Gln Ser  Ser Ser Ala Asn Arg  Arg Ala Gly 
    2570                 2575                 2580             


Ser Ser  Ser Gly Ser Gly Val  Gln Gly Ala Ser Ala  Gly Gly Leu 
    2585                 2590                 2595             


Ala Ala  Asp Ala Ser Arg Arg  Ser Gly Ala Arg Gln  Gly Gln Ala 
    2600                 2605                 2610             


Ser Ala  Gln Gly Arg Ala Gly  Ser Gln Gly Gln Ala  Gln Gly Arg 
    2615                 2620                 2625             


Val Gly  Ser Ser Ala Asp Arg  Gln Gly Arg Arg Gly  Val Ser Glu 
    2630                 2635                 2640             


Ser Gln  Ala Ser Asp Ser Glu  Gly His Ser Asp Phe  Ser Glu Gly 
    2645                 2650                 2655             


Gln Ala  Val Gly Ala His Arg  Gln Ser Gly Ala Gly  Gln Arg His 
    2660                 2665                 2670             


Glu Gln  Arg Ser Ser Arg Ser  Gln His Gly Ser Gly  Tyr Tyr Tyr 
    2675                 2680                 2685             


Glu Gln  Glu His Ser Glu Glu  Glu Ser Asp Ser Gln  His Gln His 
    2690                 2695                 2700             


Ser His  Gln His Glu Gln Gln  Arg Gly His Gln His  Gln His Gln 
    2705                 2710                 2715             


His Gln  His Glu His Glu Gln  Pro Glu Ser Gly His  Arg Gln Gln 
    2720                 2725                 2730             


Gln Ser  Ser Gly Arg Gly Asn  Gln Gly Ala His Gln  Glu Gln Gly 
    2735                 2740                 2745             


Arg Asp  Ser Ala Arg Ser Arg  Gly Ser Asn Gln Gly  His Ser Ser 
    2750                 2755                 2760             


Ser Arg  His Gln Ala Asp Ser  Pro Arg Val Ser Ala  Arg Ser Gly 
    2765                 2770                 2775             


Ser Gly  Gly Arg Gly Gln Ser  Pro Asp Ala Ser Gly  Arg Ser Ser 
    2780                 2785                 2790             


Asn Arg  Arg Asp Arg Pro Arg  Gln Pro Ser Pro Ser  Gln Ser Ser 
    2795                 2800                 2805             


Asp Ser  His Val His Ser Gly  Val Gln Val Glu Gly  Arg Arg Gly 
    2810                 2815                 2820             


Gln Ser  Ser Ser Ala Asn Arg  Arg Ala Gly Ser Ser  Ser Gly Ser 
    2825                 2830                 2835             


Gly Val  Gln Gly Ala Ser Ala  Gly Gly Leu Ala Ala  Asp Ala Ser 
    2840                 2845                 2850             


Arg Arg  Ser Gly Ala Arg Gln  Gly Gln Ala Ser Ala  Gln Gly Arg 
    2855                 2860                 2865             


Ala Gly  Ser Gln Gly Gln Ala  Gln Gly Arg Val Gly  Ser Ser Ala 
    2870                 2875                 2880             


Asp Arg  Gln Gly Arg Arg Gly  Val Ser Glu Ser Gln  Ala Ser Asp 
    2885                 2890                 2895             


Ser Glu  Gly His Ser Asp Phe  Ser Glu Gly Gln Ala  Val Gly Ala 
    2900                 2905                 2910             


His Arg  Gln Ser Gly Ala Gly  Gln Arg His Glu Gln  Arg Ser Ser 
    2915                 2920                 2925             


Arg Gly  Gln His Gly Ser Gly  Phe Tyr Pro Val Tyr  Tyr Tyr Tyr 
    2930                 2935                 2940             


Glu Gln  Glu His Ser Glu Glu  Glu Ser Asp Ser Gln  His Gln His 
    2945                 2950                 2955             


Gly His  Gln His Glu Gln Gln  Arg Gly His Gln His  Gln His Gln 
    2960                 2965                 2970             


His Gln  His Glu His Glu Gln  Pro Glu Ser Gly His  Arg Gln Gln 
    2975                 2980                 2985             


Gln Ser  Ser Gly Arg Gly His  Gln Gly Ala His Gln  Glu Gln Gly 
    2990                 2995                 3000             


Arg Asp  Ser Ala Arg Ser Arg  Gly Ser Asn Gln Gly  His Ser Ser 
    3005                 3010                 3015             


Ser Arg  His Gln Ala Asp Ser  Pro Arg Val Ser Ala  Arg Ser Gly 
    3020                 3025                 3030             


Ser Gly  Gly Arg Gly Gln Ser  Pro Asp Ala Ser Gly  Arg Ser Ser 
    3035                 3040                 3045             


Asn Arg  Arg Asp Arg Ser Arg  Gln Pro Ser Pro Ser  Gln Ser Ser 
    3050                 3055                 3060             


Asp Ser  Gln Val His Ser Gly  Val Gln Val Glu Gly  Arg Arg Gly 
    3065                 3070                 3075             


Gln Ser  Ser Ser Ala Asn Arg  Arg Ala Gly Ser Ser  Ser Gly Ser 
    3080                 3085                 3090             


Gly Val  Gln Gly Ala Ser Ala  Gly Gly Leu Ala Ala  Asp Ala Ser 
    3095                 3100                 3105             


Arg Arg  Ser Gly Ala Arg Gln  Gly Gln Ala Ser Ala  Gln Gly Arg 
    3110                 3115                 3120             


Ala Gly  Ser Gln Gly Gln Ala  Gln Gly Arg Val Gly  Ser Ser Ala 
    3125                 3130                 3135             


Asp Arg  Gln Gly Arg Arg Gly  Val Ser Glu Ser Gln  Ala Ser Asp 
    3140                 3145                 3150             


Ser Glu  Gly His Ser Asp Phe  Ser Glu Gly Gln Ala  Val Gly Ala 
    3155                 3160                 3165             


His Arg  Gln Ser Gly Ala Gly  Gln Arg His Glu Gln  Arg Ser Ser 
    3170                 3175                 3180             


Arg Gly  Gln His Gly Ser Gly  Phe Tyr Pro Val Tyr  Tyr Tyr Tyr 
    3185                 3190                 3195             


Glu Gln  Glu His Ser Glu Glu  Glu Ser Asp Ser Gln  His Gln His 
    3200                 3205                 3210             


Gly His  Gln His Glu Gln Gln  Arg Gly His Gln His  Gln His Gln 
    3215                 3220                 3225             


His Glu  His Glu Gln Pro Glu  Ser Gly His Arg Gln  Gln Gln Ser 
    3230                 3235                 3240             


Ser Gly  Arg Gly His Gln Gly  Ala His Gln Glu Gln  Gly Arg Asp 
    3245                 3250                 3255             


Ser Ala  Arg Ser Arg Gly Ser  Asn Gln Gly His Ser  Ser Ser Arg 
    3260                 3265                 3270             


His Gln  Ala Asp Ser Pro Arg  Val Ser Ala Arg Ser  Gly Ser Gly 
    3275                 3280                 3285             


Gly Arg  Gly Gln Ser Pro Asp  Ala Ser Gly Arg Ser  Ser Asn Arg 
    3290                 3295                 3300             


Arg Asp  Arg Pro Arg Gln Pro  Ser Pro Ser Gln Ser  Ser Asp Ser 
    3305                 3310                 3315             


Gln Val  His Ser Gly Val Gln  Val Glu Gly Arg Arg  Gly Gln Ser 
    3320                 3325                 3330             


Ser Ser  Ala Asn Arg Arg Ala  Gly Ser Ser Ser Gly  Ser Gly Val 
    3335                 3340                 3345             


Gln Gly  Ala Ser Ala Gly Gly  Leu Ala Ala Asp Ala  Ser Arg Arg 
    3350                 3355                 3360             


Ser Gly  Ala Leu Gln Gly Gln  Ala Ser Ala Gln Gly  Arg Ala Gly 
    3365                 3370                 3375             


Ser Gln  Gly Gln Ala Gln Gly  Arg Val Gly Ser Ser  Ala Asp Arg 
    3380                 3385                 3390             


Gln Gly  Arg Arg Gly Val Ser  Glu Ser Gln Ala Ser  Asp Ser Glu 
    3395                 3400                 3405             


Gly His  Ser Asp Phe Ser Glu  Gly Gln Ala Val Gly  Ala His Arg 
    3410                 3415                 3420             


Gln Ser  Gly Ala Gly Gln Arg  His Glu Gln Arg Ser  Ser Arg Gly 
    3425                 3430                 3435             


Gln His  Gly Ser Gly Tyr Tyr  Tyr Glu Gln Glu His  Ser Glu Glu 
    3440                 3445                 3450             


Glu Ser  Asp Ser Gln His Gln  His Gly His Gln His  Glu Gln Gln 
    3455                 3460                 3465             


Arg Gly  His Gln His Gln His  Gln His Gln His Glu  His Glu Gln 
    3470                 3475                 3480             


Pro Glu  Ser Gly His Arg Gln  Gln Gln Ser Ser Gly  Arg Gly His 
    3485                 3490                 3495             


Gln Gly  Ala His Gln Glu Gln  Gly Arg Asp Ser Ala  Arg Ser Arg 
    3500                 3505                 3510             


Gly Ser  Asn Gln Gly His Ser  Ser Ser Arg His Gln  Ala Asp Ser 
    3515                 3520                 3525             


Pro Arg  Val Ser Ala Arg Ser  Gly Ser Gly Gly Arg  Gly Gln Ser 
    3530                 3535                 3540             


Pro Asp  Ala Ser Gly Arg Ser  Ser Asn Arg Arg Asp  Arg Pro Arg 
    3545                 3550                 3555             


Gln Pro  Ser Pro Ser Gln Ser  Ser Asp Ser Gln Val  His Ser Gly 
    3560                 3565                 3570             


Val Gln  Val Glu Gly Arg Arg  Gly Gln Ser Ser Ser  Ala Asn Arg 
    3575                 3580                 3585             


Arg Ala  Gly Ser Ser Ser Gly  Ser Gly Val Gln Gly  Ala Ser Ala 
    3590                 3595                 3600             


Gly Gly  Leu Ala Ala Asp Ala  Ser Arg Arg Ser Gly  Ala Arg Gln 
    3605                 3610                 3615             


Gly Gln  Ala Ser Ala Gln Gly  Arg Ala Gly Ser Gln  Gly Gln Ala 
    3620                 3625                 3630             


Gln Gly  Arg Val Gly Ser Ser  Ala Asp Arg Gln Gly  Arg Arg Gly 
    3635                 3640                 3645             


Val Ser  Gly Ser Gln Ala Ser  Asp Ser Glu Gly His  Ser Asp Phe 
    3650                 3655                 3660             


Ser Glu  Gly Gln Ala Val Gly  Ala His Arg Gln Ser  Gly Ala Gly 
    3665                 3670                 3675             


Gln Arg  His Glu Gln Arg Ser  Ser Arg Gly Gln His  Gly Ser Gly 
    3680                 3685                 3690             


Tyr Tyr  Tyr Glu Gln Glu His  Ser Glu Glu Glu Ser  Asp Ser Gln 
    3695                 3700                 3705             


His Gln  His Gly His Gln His  Glu Gln Gln Arg Gly  His Gln His 
    3710                 3715                 3720             


Gln His  Gln His Gln His Glu  His Glu Gln Pro Glu  Ser Gly His 
    3725                 3730                 3735             


Arg Gln  Gln Gln Phe Ser Gly  Arg Gly His Gln Gly  Ala His Gln 
    3740                 3745                 3750             


Glu Gln  Gly Arg Asp Ser Ala  Arg Ser Arg Gly Ser  Asn Gln Gly 
    3755                 3760                 3765             


His Ser  Ser Ser Arg His Gln  Ala Asp Ser Pro Arg  Val Ser Ala 
    3770                 3775                 3780             


Arg Ser  Gly Ser Gly Gly Arg  Gly Gln Ser Pro Asp  Ala Ser Gly 
    3785                 3790                 3795             


Arg Ser  Ser Asn Arg Arg Asp  Arg Pro Arg Gln Pro  Ser Pro Ser 
    3800                 3805                 3810             


Gln Ser  Ser Asp Ser Gln Val  His Ser Gly Val Gln  Val Glu Gly 
    3815                 3820                 3825             


Arg Arg  Gly Gln Ser Ser Ser  Ala Asn Arg Arg Ala  Gly Ser Ser 
    3830                 3835                 3840             


Ser Ser  Ser Gly Val Gln Gly  Ala Ser Ala Gly Gly  Leu Ala Ala 
    3845                 3850                 3855             


Asp Ala  Ser Arg Arg Ser Gly  Ala Arg Gln Gly Gln  Ala Ser Ala 
    3860                 3865                 3870             


Gln Gly  Arg Ala Gly Ser Gln  Gly Gln Ala Gln Gly  Arg Val Gly 
    3875                 3880                 3885             


Ser Ser  Ala Asp Arg Gln Gly  Arg Arg Gly Val Ser  Glu Ser Gln 
    3890                 3895                 3900             


Ala Ser  Asp Ser Glu Gly His  Ser Asp Phe Ser Glu  Gly Gln Ala 
    3905                 3910                 3915             


Val Gly  Ala His Arg Gln Ser  Gly Ala Gly Gln Arg  His Glu Gln 
    3920                 3925                 3930             


Arg Ser  Ser Arg Gly Gln His  Gly Ser Gly Phe Tyr  Pro Val Tyr 
    3935                 3940                 3945             


Tyr Tyr  Tyr Glu Gln Glu His  Ser Glu Glu Glu Ser  Asp Ser Gln 
    3950                 3955                 3960             


His Gln  His Gly His Gln His  Glu Gln Gln Arg Gly  His Gln His 
    3965                 3970                 3975             


Gln His  Gln His Gln His Glu  His Glu Gln Pro Glu  Ser Gly His 
    3980                 3985                 3990             


Arg Gln  Gln Gln Phe Ser Gly  Arg Gly His Gln Gly  Ala His Gln 
    3995                 4000                 4005             


Glu Gln  Gly Arg Asp Ser Ala  Arg Ser Arg Gly Ser  Asn Gln Gly 
    4010                 4015                 4020             


His Ser  Ser Ser Arg His Gln  Ala Asp Ser Pro Arg  Val Ser Ala 
    4025                 4030                 4035             


Arg Ser  Gly Ser Gly Gly Arg  Gly Gln Ser Pro Asp  Ala Ser Gly 
    4040                 4045                 4050             


Arg Ser  Ser Asn Arg Arg Asp  Arg Pro Arg Gln Pro  Ser Pro Ser 
    4055                 4060                 4065             


Gln Ser  Ser Asp Ser Gln Val  His Ser Gly Val Gln  Val Glu Gly 
    4070                 4075                 4080             


Arg Arg  Gly Gln Ser Ser Ser  Ala Asn Arg Arg Ala  Gly Ser Ser 
    4085                 4090                 4095             


Ser Gly  Ser Gly Val Gln Gly  Ala Ser Ala Gly Gly  Leu Ala Ala 
    4100                 4105                 4110             


Asp Ala  Ser Arg Arg Ser Gly  Ala Arg Gln Gly Gln  Ala Ser Ala 
    4115                 4120                 4125             


Gln Gly  Arg Ala Gly Ser Gln  Gly Gln Ala Gln Gly  Arg Val Gly 
    4130                 4135                 4140             


Ser Ser  Ala Asp Arg Gln Gly  Arg Arg Gly Val Ser  Glu Ser Gln 
    4145                 4150                 4155             


Ala Ser  Asp Ser Glu Gly His  Ser Asp Phe Ser Glu  Gly Gln Ala 
    4160                 4165                 4170             


Val Gly  Ala His Arg Gln Ser  Gly Ala Gly Gln Arg  His Glu Gln 
    4175                 4180                 4185             


Arg Ser  Ser Arg Gly Gln His  Gly Ser Gly Tyr Tyr  Tyr Glu Gln 
    4190                 4195                 4200             


Glu His  Ser Glu Glu Glu Ser  Asp Ser Gln His Gln  Gln Gly His 
    4205                 4210                 4215             


Gln His  Glu Gln Gln Arg Gly  His Gln His Gln His  Gln His Gln 
    4220                 4225                 4230             


His Glu  His Glu Gln Pro Glu  Ser Gly His Arg Gln  Gln Gln Ser 
    4235                 4240                 4245             


Ser Gly  Arg Gly His Gln Gly  Ala His Gln Glu Gln  Gly Arg Asp 
    4250                 4255                 4260             


Ser Ala  Arg Ser Arg Gly Ser  Asn Gln Gly His Ser  Ser Ser Arg 
    4265                 4270                 4275             


His Gln  Ala Asp Ser Pro Arg  Val Ser Ala Arg Ser  Gly Ser Gly 
    4280                 4285                 4290             


Gly Arg  Gly Gln Ser Pro Asp  Gly Ser Gly Arg Ser  Ser Asn Arg 
    4295                 4300                 4305             


Arg Asp  Arg Pro Arg Gln Pro  Ser Ala Ser Gln Ser  Ser Asp Ser 
    4310                 4315                 4320             


Gln Val  His Ser Gly Val Gln  Val Glu Ala Gln Arg  Gly Gln Ser 
    4325                 4330                 4335             


Ser Ser  Ala Asn Arg Arg Ala  Gly Ser Ser Ser Gly  Ser Gly Val 
    4340                 4345                 4350             


Gln Ser  Ala Ala Ala Ser Gly  Gln Gly Gly Tyr Glu  Ser Ile Phe 
    4355                 4360                 4365             


Thr Ala  Lys His Leu Asp Phe  Asn Gln Ser His Ser  Tyr Tyr Tyr 
    4370                 4375                 4380             


Tyr 
    


<210> 13
<211> 554
<212> PRT
<213> Mus musculus

<400> 13
Met Ser Ala Leu Leu Glu Ser Ile Thr Ser Met Ile Glu Ile Phe Gln 
1               5                   10                  15      


Gln Tyr Ser Thr Ser Asp Lys Glu Glu Glu Thr Leu Ser Lys Glu Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Gly Gln Leu Gln Ala Val Leu Lys Asn Pro 
        35                  40                  45              


Asp Asp Gln Asp Ile Ala Glu Val Phe Met Gln Met Leu Asp Val Asp 
    50                  55                  60                  


His Asp Asp Lys Leu Asp Phe Ala Glu Tyr Leu Leu Leu Val Leu Lys 
65                  70                  75                  80  


Leu Ala Lys Ala Tyr Tyr Glu Ala Ser Lys Asn Glu Ser Phe Gln Thr 
                85                  90                  95      


His Gly Ser Asn Gly Arg Ser Lys Thr Asp Tyr Lys Gly Leu Glu Glu 
            100                 105                 110         


Glu Gly Glu Glu Gly Asn Glu Gln Asn Leu Arg Arg Arg His Gly Gly 
        115                 120                 125             


Thr Asp Gly Lys Arg Lys Ser Asp Arg Thr Arg Ser Pro Asn Gly Lys 
    130                 135                 140                 


Arg Gly Lys Arg Gln Glu Ser Arg Cys Arg Ser Glu Gly Lys Asp Lys 
145                 150                 155                 160 


His Arg Arg Glu Pro Glu Lys His Arg His Gln Gln Asp Ser Lys Arg 
                165                 170                 175     


Lys Gln Arg His Gly Ser Gly Ser Thr Glu Arg Lys Asp Asn Arg Asn 
            180                 185                 190         


Lys Lys Asn Arg Gln Ser Lys Glu Arg Asn Tyr Asp Glu Ile Tyr Asp 
        195                 200                 205             


Asn Gly Lys Tyr Asn Glu Asp Trp Glu Ala Ser Tyr Asn Asn Cys Tyr 
    210                 215                 220                 


Tyr Lys Thr Gln Asn Thr Thr Leu Asp Gln Arg Glu Gly Asn Arg Arg 
225                 230                 235                 240 


Pro Arg Ala Asp Ser Gln Lys Glu Pro Gln Ser Phe His Gly Gln Ala 
                245                 250                 255     


Asp Asn Ser Asp Ser Glu Gly Gly Arg Gln Gln Ser His Ser Lys Pro 
            260                 265                 270         


Ser Pro Val Arg Ala Asp Gln Arg Arg Ser Arg Ala Gly Gln Ala Gly 
        275                 280                 285             


Ser Ser Lys Val Ser Ala Arg Ser Gly Ser Gly Gly Arg Gly Gln Ser 
    290                 295                 300                 


Pro Asp Gly Ser Gly Arg Ser Ser Asn Arg Arg Asp Arg Pro Arg Gln 
305                 310                 315                 320 


Pro Ser Pro Ser Gln Ser Ser Asp Ser Gln Val His Ser Gly Val Gln 
                325                 330                 335     


Val Glu Gly Arg Arg Gly Gln Ser Ser Ser Ala Asn Arg Arg Ala Gly 
            340                 345                 350         


Ser Ser Ser Gly Ser Gly Val Gln Gly Ala Ser Ala Gly Gly Leu Ala 
        355                 360                 365             


Ala Asp Ala Ser Arg Arg Thr Gly Ala Leu Gln Gly Gln Ala Ser Ala 
    370                 375                 380                 


Gln Gly Arg Ala Gly Ser Gln Gly Gln Ala Gln Gly Arg Val Gly Ser 
385                 390                 395                 400 


Ser Ala Asp Arg Gln Gly Arg Arg Gly Val Ser Glu Ser Gln Ala Ser 
                405                 410                 415     


Asp Ser Glu Gly Gln Ser Asp Phe Ser Glu Gly Gln Ala Val Gly Ala 
            420                 425                 430         


His Arg Gln Ser Gly Ala Gly Gln Arg His Glu Gln Arg Ser Ser Arg 
        435                 440                 445             


Gly Gln Tyr Gly Ser Gly Phe Tyr Pro Val Tyr Tyr Tyr Tyr Glu Gln 
    450                 455                 460                 


Glu His Ser Glu Glu Glu Ser Asp Ser Gln His Gly His Gln His Glu 
465                 470                 475                 480 


Gln Gln Arg Gly His Gln His Gln His Gln His Glu His Glu Gln Pro 
                485                 490                 495     


Glu Ser Gly His Arg Gln Gln Gln Ser Ser Gly Arg Gly His Gln Gly 
            500                 505                 510         


Ala His Gln Glu Gln Gly Arg Asp Ser Ala Arg Ser Arg Gly Ser Asn 
        515                 520                 525             


Gln Gly His Ser Ser Ser Arg His Gln Ala Asp Ser Pro Arg Val Ser 
    530                 535                 540                 


Val Arg Ser Gly Ser Gly Gly Arg Gly Gln 
545                 550                 


<210> 14
<211> 336
<212> PRT
<213> Mus musculus

<400> 14
Pro Asp Gly Ser Gly Arg Ser Ser Asn Arg Arg Asp Arg Pro Arg Gln 
1               5                   10                  15      


Leu Ser Pro Ser Gln Ser Ser Asp Ser Gln Val His Ser Gly Val Gln 
            20                  25                  30          


Val Glu Gly Arg Arg Gly His Ser Ser Ser Ala Asn Arg Arg Ala Gly 
        35                  40                  45              


Ser Ser Ser Gly Ser Gly Val Gln Gly Ala Ser Ala Gly Gly Leu Ala 
    50                  55                  60                  


Ala Asp Ala Ser Arg Arg Ser Gly Ala Arg Gln Gly Gln Ala Ser Ala 
65                  70                  75                  80  


Gln Gly Arg Ala Gly Ser Gln Gly Gln Ala Gln Gly Arg Val Ser Ser 
                85                  90                  95      


Ser Ala Asp Arg Gln Gly Arg Arg Gly Val Ser Glu Ser Arg Ala Ser 
            100                 105                 110         


Asp Ser Glu Gly His Ser Asp Phe Ser Glu Gly Gln Ala Val Gly Ala 
        115                 120                 125             


His Arg Gln Ser Gly Ala Gly Gln Arg His Glu Gln Arg Ser Ser Arg 
    130                 135                 140                 


Gly Gln His Gly Ser Gly Tyr Tyr Tyr Glu Gln Glu His Ser Glu Glu 
145                 150                 155                 160 


Glu Ser Asp Ser Gln His Gln His Gly His Gln His Glu Gln Gln Arg 
                165                 170                 175     


Gly His Gln His Gln His Gln His Gln His Glu His Glu Gln Pro Glu 
            180                 185                 190         


Ser Gly His Arg Gln Gln Gln Ser Ser Gly Arg Gly His Gln Gly Ala 
        195                 200                 205             


His Gln Glu Gln Gly Arg Asp Ser Ala Arg Pro Arg Gly Ser Asn Gln 
    210                 215                 220                 


Gly His Ser Ser Ser Arg His Gln Ala Asp Ser Pro Arg Val Ser Ala 
225                 230                 235                 240 


Arg Ser Gly Ser Gly Gly Arg Gly Gln Ser Pro Asp Ala Ser Gly Arg 
                245                 250                 255     


Ser Ser Asn Arg Arg Asp Arg Pro Arg Gln Pro Ser Pro Ser Gln Ser 
            260                 265                 270         


Ser Asp Ser Gln Val His Ser Gly Val Gln Val Glu Ala Gln Arg Gly 
        275                 280                 285             


Gln Ser Ser Ser Ala Asn Arg Arg Ala Gly Ser Ser Ser Gly Ser Gly 
    290                 295                 300                 


Val Gln Gly Ala Ala Ala Ser Gly Gln Gly Gly Tyr Glu Ser Ile Phe 
305                 310                 315                 320 


Thr Ala Lys His Leu Asp Phe Asn Gln Ser His Ser Tyr Tyr Tyr Tyr 
                325                 330                 335     


<210> 15
<211> 250
<212> PRT
<213> Mus musculus

<400> 15
Gly Gly Leu Ala Ala Asp Ala Ser Arg Arg Ser Gly Ala Leu Gln Gly 
1               5                   10                  15      


Gln Ala Ser Ala Gln Gly Arg Ala Gly Ser Gln Gly Gln Ala Gln Gly 
            20                  25                  30          


Arg Val Gly Ser Ser Ala Asp Arg Gln Gly Arg Arg Gly Val Ser Glu 
        35                  40                  45              


Ser Gln Ala Ser Asp Ser Glu Gly His Ser Asp Phe Ser Glu Gly Gln 
    50                  55                  60                  


Ala Val Gly Ala His Arg Gln Ser Gly Ala Gly Gln Arg His Glu Gln 
65                  70                  75                  80  


Arg Ser Ser Arg Gly Gln His Gly Ser Gly Tyr Tyr Tyr Glu Gln Glu 
                85                  90                  95      


His Ser Glu Glu Glu Ser Asp Ser Gln His Gln His Gly His Gln His 
            100                 105                 110         


Glu Gln Gln Arg Gly His Gln His Gln His Gln His Gln His Glu His 
        115                 120                 125             


Glu Gln Pro Glu Ser Gly His Arg Gln Gln Gln Ser Ser Gly Arg Gly 
    130                 135                 140                 


His Gln Gly Ala His Gln Glu Gln Gly Arg Asp Ser Ala Arg Ser Arg 
145                 150                 155                 160 


Gly Ser Asn Gln Gly His Ser Ser Ser Arg His Gln Ala Asp Ser Pro 
                165                 170                 175     


Arg Val Ser Ala Arg Ser Gly Ser Gly Gly Arg Gly Gln Ser Pro Asp 
            180                 185                 190         


Ala Ser Gly Arg Ser Ser Asn Arg Arg Asp Arg Pro Arg Gln Pro Ser 
        195                 200                 205             


Pro Ser Gln Ser Ser Asp Ser Gln Val His Ser Gly Val Gln Val Glu 
    210                 215                 220                 


Gly Arg Arg Gly Gln Ser Ser Ser Ala Asn Arg Arg Ala Gly Ser Ser 
225                 230                 235                 240 


Ser Ser Ser Gly Val Gln Gly Ala Ser Ala 
                245                 250 


<210> 16
<211> 2642
<212> PRT
<213> Mus musculus

<400> 16
Met Ser Thr Asn Ser Pro Ser Pro Ala Thr Gly Ser Ser Ser Ser Ala 
1               5                   10                  15      


Asp Ser Pro Arg Val Ser Ala Arg Ser Gly Ser Gly Gly Arg Gly Gln 
            20                  25                  30          


Ser Pro Asp Ala Ser Gly Arg Ser Ser Asn Arg Arg Asp Arg Pro Arg 
        35                  40                  45              


Gln Pro Ser Pro Ser Gln Ser Ser Asp Ser Gln Val His Ser Gly Val 
    50                  55                  60                  


Gln Val Glu Gly Arg Arg Gly Gln Ser Ser Ser Ala Asn Arg Arg Ala 
65                  70                  75                  80  


Gly Ser Ser Ser Gly Ser Gly Val Gln Gly Ala Ser Ala Gly Gly Leu 
                85                  90                  95      


Ala Ala Asp Ala Ser Arg Arg Ser Gly Ala Arg Gln Gly Gln Ala Ser 
            100                 105                 110         


Ala Gln Gly Arg Ala Gly Ser Gln Gly Gln Ala Gln Gly Arg Val Gly 
        115                 120                 125             


Ser Ser Ala Asp Arg Gln Gly Arg Arg Gly Val Ser Glu Ser Gln Ala 
    130                 135                 140                 


Ser Asp Ser Glu Gly His Ser Asp Phe Ser Glu Gly Gln Ala Val Gly 
145                 150                 155                 160 


Ala His Arg Gln Ser Gly Ala Gly Gln Arg His Glu Gln Arg Ser Ser 
                165                 170                 175     


Arg Gly Gln His Gly Ser Gly Phe Tyr Pro Val Tyr Tyr Tyr Tyr Glu 
            180                 185                 190         


Gln Glu His Ser Glu Glu Glu Ser Asp Ser Gln His Gln His Gly His 
        195                 200                 205             


Gln His Glu Gln Gln Arg Gly His Gln His Gln His Gln His Gln His 
    210                 215                 220                 


Glu His Glu Gln Pro Glu Ser Gly His Arg Gln Gln Gln Ser Ser Gly 
225                 230                 235                 240 


Arg Gly His Gln Gly Ala His Gln Glu Gln Gly Arg Asp Ser Ala Arg 
                245                 250                 255     


Ser Arg Gly Ser Asn Gln Gly His Ser Ser Ser Arg His Gln Ala Asp 
            260                 265                 270         


Ser Pro Arg Val Ser Ala Arg Ser Gly Ser Gly Gly Arg Gly Gln Ser 
        275                 280                 285             


Pro Asp Ala Ser Gly Arg Ser Ser Asn Arg Arg Asp Arg Pro Arg Gln 
    290                 295                 300                 


Pro Ser Pro Ser Gln Ser Ser Asp Ser Gln Val His Ser Gly Val Gln 
305                 310                 315                 320 


Val Glu Gly Arg Arg Gly Gln Ser Ser Ser Ala Asn Arg Arg Ala Gly 
                325                 330                 335     


Ser Ser Ser Gly Ser Gly Val Gln Gly Ala Ser Ala Gly Gly Leu Ala 
            340                 345                 350         


Ala Asp Ala Ser Arg Arg Ser Gly Ala Arg Gln Gly Gln Ala Ser Ala 
        355                 360                 365             


Gln Gly Arg Ala Gly Ser Gln Gly Gln Ala Gln Gly Arg Val Gly Ser 
    370                 375                 380                 


Ser Ala Asp Arg Gln Gly Arg Arg Gly Val Ser Glu Ser Gln Ala Ser 
385                 390                 395                 400 


Asp Ser Glu Gly His Ser Asp Phe Ser Glu Gly Gln Ala Val Gly Ala 
                405                 410                 415     


His Arg Gln Ser Gly Ala Gly Gln Arg His Glu Gln Arg Ser Ser Arg 
            420                 425                 430         


Gly Gln His Gly Ser Gly Tyr Tyr Tyr Glu Gln Glu His Ser Glu Glu 
        435                 440                 445             


Glu Ser Asp Ser Gln His Gln His Ser His Gln His Glu Gln Gln Arg 
    450                 455                 460                 


Gly His Gln His Gln His Gln His Gln His Glu His Glu Gln Pro Glu 
465                 470                 475                 480 


Ser Gly His Arg Gln Gln Gln Phe Ser Gly Arg Gly His Gln Gly Ala 
                485                 490                 495     


His Gln Glu Gln Gly Arg Asp Ser Ala Arg Ser Arg Gly Ser Asn Gln 
            500                 505                 510         


Gly His Ser Ser Ser Arg His Gln Ala Asp Ser Pro Arg Val Ser Ala 
        515                 520                 525             


Arg Ser Gly Ser Gly Gly Arg Gly Gln Ser Pro Asp Ala Ser Gly Arg 
    530                 535                 540                 


Ser Ser Asn Arg Arg Asp Arg Pro Arg Gln Pro Ser Pro Ser Gln Ser 
545                 550                 555                 560 


Ser Asp Ser Gln Val His Ser Gly Val Gln Val Glu Gly Arg Arg Gly 
                565                 570                 575     


Gln Ser Ser Ser Ala Asn Arg Arg Ala Gly Ser Ser Ser Gly Ser Gly 
            580                 585                 590         


Val Gln Gly Ala Ser Ala Gly Gly Leu Ala Ala Asp Ala Ser Arg Arg 
        595                 600                 605             


Ser Gly Ala Arg Gln Gly Gln Ala Ser Ala Gln Gly Arg Ala Gly Ser 
    610                 615                 620                 


Gln Gly Gln Ala Gln Gly Arg Val Gly Ser Ser Ala Asp Arg Gln Gly 
625                 630                 635                 640 


Arg Arg Gly Val Ser Glu Ser Gln Ala Ser Asp Ser Glu Gly His Ser 
                645                 650                 655     


Asp Phe Ser Glu Gly Gln Ala Val Gly Ala His Arg Gln Ser Gly Ala 
            660                 665                 670         


Gly Gln Arg His Glu Gln Arg Ser Ser Arg Gly Gln His Gly Ser Gly 
        675                 680                 685             


Phe Tyr Pro Val Tyr Tyr Tyr Tyr Glu Gln Glu His Ser Glu Glu Glu 
    690                 695                 700                 


Ser Asp Ser Gln His Gln His Gly His Gln His Glu Gln Gln Arg Gly 
705                 710                 715                 720 


His Gln His Gln His Gln His Gln His Glu His Glu Gln Pro Glu Ser 
                725                 730                 735     


Gly His Arg Gln Gln Gln Ser Ser Gly Arg Gly His Gln Gly Ala His 
            740                 745                 750         


Gln Glu Gln Gly Arg Asp Ser Ala Arg Ser Arg Gly Ser Asn Gln Gly 
        755                 760                 765             


His Ser Ser Ser Arg His Gln Ala Asp Ser Pro Arg Val Ser Ala Arg 
    770                 775                 780                 


Ser Gly Ser Gly Gly Arg Gly Gln Ser Pro Asp Ala Ser Gly Arg Ser 
785                 790                 795                 800 


Ser Asn Arg Arg Asp Arg Pro Arg Gln Pro Ser Pro Ser Gln Ser Ser 
                805                 810                 815     


Asp Ser Gln Val His Ser Gly Val Gln Val Glu Gly Arg Arg Gly Gln 
            820                 825                 830         


Ser Ser Ser Ala Asn Arg Arg Ala Gly Ser Ser Ser Gly Ser Gly Val 
        835                 840                 845             


Gln Gly Ala Ser Ala Gly Gly Leu Ala Ala Asp Ala Ser Arg Arg Ser 
    850                 855                 860                 


Gly Ala Arg Gln Gly Gln Ala Ser Ala Gln Gly Arg Ala Gly Ser Gln 
865                 870                 875                 880 


Gly Gln Ala Gln Gly Arg Val Gly Ser Ser Ala Asp Arg Gln Gly Arg 
                885                 890                 895     


Arg Gly Val Ser Glu Ser Gln Ala Ser Asp Ser Glu Gly His Ser Asp 
            900                 905                 910         


Phe Ser Glu Gly Gln Ala Val Gly Ala His Arg Gln Ser Gly Ala Gly 
        915                 920                 925             


Gln Arg His Glu Gln Arg Ser Ser Arg Ser Gln His Gly Ser Gly Tyr 
    930                 935                 940                 


Tyr Tyr Glu Gln Glu His Ser Glu Glu Glu Ser Asp Ser Gln His Gln 
945                 950                 955                 960 


His Ser His Gln His Glu Gln Gln Arg Gly His Gln His Gln His Gln 
                965                 970                 975     


His Gln His Glu His Glu Gln Pro Glu Ser Gly His Arg Gln Gln Gln 
            980                 985                 990         


Ser Ser Gly Arg Gly Asn Gln Gly  Ala His Gln Glu Gln  Gly Arg Asp 
        995                 1000                 1005             


Ser Ala  Arg Ser Arg Gly Ser  Asn Gln Gly His Ser  Ser Ser Arg 
    1010                 1015                 1020             


His Gln  Ala Asp Ser Pro Arg  Val Ser Ala Arg Ser  Gly Ser Gly 
    1025                 1030                 1035             


Gly Arg  Gly Gln Ser Pro Asp  Ala Ser Gly Arg Ser  Ser Asn Arg 
    1040                 1045                 1050             


Arg Asp  Arg Pro Arg Gln Pro  Ser Pro Ser Gln Ser  Ser Asp Ser 
    1055                 1060                 1065             


His Val  His Ser Gly Val Gln  Val Glu Gly Arg Arg  Gly Gln Ser 
    1070                 1075                 1080             


Ser Ser  Ala Asn Arg Arg Ala  Gly Ser Ser Ser Gly  Ser Gly Val 
    1085                 1090                 1095             


Gln Gly  Ala Ser Ala Gly Gly  Leu Ala Ala Asp Ala  Ser Arg Arg 
    1100                 1105                 1110             


Ser Gly  Ala Arg Gln Gly Gln  Ala Ser Ala Gln Gly  Arg Ala Gly 
    1115                 1120                 1125             


Ser Gln  Gly Gln Ala Gln Gly  Arg Val Gly Ser Ser  Ala Asp Arg 
    1130                 1135                 1140             


Gln Gly  Arg Arg Gly Val Ser  Glu Ser Gln Ala Ser  Asp Ser Glu 
    1145                 1150                 1155             


Gly His  Ser Asp Phe Ser Glu  Gly Gln Ala Val Gly  Ala His Arg 
    1160                 1165                 1170             


Gln Ser  Gly Ala Gly Gln Arg  His Glu Gln Arg Ser  Ser Arg Gly 
    1175                 1180                 1185             


Gln His  Gly Ser Gly Phe Tyr  Pro Val Tyr Tyr Tyr  Tyr Glu Gln 
    1190                 1195                 1200             


Glu His  Ser Glu Glu Glu Ser  Asp Ser Gln His Gln  His Gly His 
    1205                 1210                 1215             


Gln His  Glu Gln Gln Arg Gly  His Gln His Gln His  Gln His Gln 
    1220                 1225                 1230             


His Glu  His Glu Gln Pro Glu  Ser Gly His Arg Gln  Gln Gln Ser 
    1235                 1240                 1245             


Ser Gly  Arg Gly His Gln Gly  Ala His Gln Glu Gln  Gly Arg Asp 
    1250                 1255                 1260             


Ser Ala  Arg Ser Arg Gly Ser  Asn Gln Gly His Ser  Ser Ser Arg 
    1265                 1270                 1275             


His Gln  Ala Asp Ser Pro Arg  Val Ser Ala Arg Ser  Gly Ser Gly 
    1280                 1285                 1290             


Gly Arg  Gly Gln Ser Pro Asp  Ala Ser Gly Arg Ser  Ser Asn Arg 
    1295                 1300                 1305             


Arg Asp  Arg Ser Arg Gln Pro  Ser Pro Ser Gln Ser  Ser Asp Ser 
    1310                 1315                 1320             


Gln Val  His Ser Gly Val Gln  Val Glu Gly Arg Arg  Gly Gln Ser 
    1325                 1330                 1335             


Ser Ser  Ala Asn Arg Arg Ala  Gly Ser Ser Ser Gly  Ser Gly Val 
    1340                 1345                 1350             


Gln Gly  Ala Ser Ala Gly Gly  Leu Ala Ala Asp Ala  Ser Arg Arg 
    1355                 1360                 1365             


Ser Gly  Ala Arg Gln Gly Gln  Ala Ser Ala Gln Gly  Arg Ala Gly 
    1370                 1375                 1380             


Ser Gln  Gly Gln Ala Gln Gly  Arg Val Gly Ser Ser  Ala Asp Arg 
    1385                 1390                 1395             


Gln Gly  Arg Arg Gly Val Ser  Glu Ser Gln Ala Ser  Asp Ser Glu 
    1400                 1405                 1410             


Gly His  Ser Asp Phe Ser Glu  Gly Gln Ala Val Gly  Ala His Arg 
    1415                 1420                 1425             


Gln Ser  Gly Ala Gly Gln Arg  His Glu Gln Arg Ser  Ser Arg Gly 
    1430                 1435                 1440             


Gln His  Gly Ser Gly Phe Tyr  Pro Val Tyr Tyr Tyr  Tyr Glu Gln 
    1445                 1450                 1455             


Glu His  Ser Glu Glu Glu Ser  Asp Ser Gln His Gln  His Gly His 
    1460                 1465                 1470             


Gln His  Glu Gln Gln Arg Gly  His Gln His Gln His  Gln His Glu 
    1475                 1480                 1485             


His Glu  Gln Pro Glu Ser Gly  His Arg Gln Gln Gln  Ser Ser Gly 
    1490                 1495                 1500             


Arg Gly  His Gln Gly Ala His  Gln Glu Gln Gly Arg  Asp Ser Ala 
    1505                 1510                 1515             


Arg Ser  Arg Gly Ser Asn Gln  Gly His Ser Ser Ser  Arg His Gln 
    1520                 1525                 1530             


Ala Asp  Ser Pro Arg Val Ser  Ala Arg Ser Gly Ser  Gly Gly Arg 
    1535                 1540                 1545             


Gly Gln  Ser Pro Asp Ala Ser  Gly Arg Ser Ser Asn  Arg Arg Asp 
    1550                 1555                 1560             


Arg Pro  Arg Gln Pro Ser Pro  Ser Gln Ser Ser Asp  Ser Gln Val 
    1565                 1570                 1575             


His Ser  Gly Val Gln Val Glu  Gly Arg Arg Gly Gln  Ser Ser Ser 
    1580                 1585                 1590             


Ala Asn  Arg Arg Ala Gly Ser  Ser Ser Gly Ser Gly  Val Gln Gly 
    1595                 1600                 1605             


Ala Ser  Ala Gly Gly Leu Ala  Ala Asp Ala Ser Arg  Arg Ser Gly 
    1610                 1615                 1620             


Ala Leu  Gln Gly Gln Ala Ser  Ala Gln Gly Arg Ala  Gly Ser Gln 
    1625                 1630                 1635             


Gly Gln  Ala Gln Gly Arg Val  Gly Ser Ser Ala Asp  Arg Gln Gly 
    1640                 1645                 1650             


Arg Arg  Gly Val Ser Glu Ser  Gln Ala Ser Asp Ser  Glu Gly His 
    1655                 1660                 1665             


Ser Asp  Phe Ser Glu Gly Gln  Ala Val Gly Ala His  Arg Gln Ser 
    1670                 1675                 1680             


Gly Ala  Gly Gln Arg His Glu  Gln Arg Ser Ser Arg  Gly Gln His 
    1685                 1690                 1695             


Gly Ser  Gly Tyr Tyr Tyr Glu  Gln Glu His Ser Glu  Glu Glu Ser 
    1700                 1705                 1710             


Asp Ser  Gln His Gln His Gly  His Gln His Glu Gln  Gln Arg Gly 
    1715                 1720                 1725             


His Gln  His Gln His Gln His  Gln His Glu His Glu  Gln Pro Glu 
    1730                 1735                 1740             


Ser Gly  His Arg Gln Gln Gln  Ser Ser Gly Arg Gly  His Gln Gly 
    1745                 1750                 1755             


Ala His  Gln Glu Gln Gly Arg  Asp Ser Ala Arg Ser  Arg Gly Ser 
    1760                 1765                 1770             


Asn Gln  Gly His Ser Ser Ser  Arg His Gln Ala Asp  Ser Pro Arg 
    1775                 1780                 1785             


Val Ser  Ala Arg Ser Gly Ser  Gly Gly Arg Gly Gln  Ser Pro Asp 
    1790                 1795                 1800             


Ala Ser  Gly Arg Ser Ser Asn  Arg Arg Asp Arg Pro  Arg Gln Pro 
    1805                 1810                 1815             


Ser Pro  Ser Gln Ser Ser Asp  Ser Gln Val His Ser  Gly Val Gln 
    1820                 1825                 1830             


Val Glu  Gly Arg Arg Gly Gln  Ser Ser Ser Ala Asn  Arg Arg Ala 
    1835                 1840                 1845             


Gly Ser  Ser Ser Gly Ser Gly  Val Gln Gly Ala Ser  Ala Gly Gly 
    1850                 1855                 1860             


Leu Ala  Ala Asp Ala Ser Arg  Arg Ser Gly Ala Arg  Gln Gly Gln 
    1865                 1870                 1875             


Ala Ser  Ala Gln Gly Arg Ala  Gly Ser Gln Gly Gln  Ala Gln Gly 
    1880                 1885                 1890             


Arg Val  Gly Ser Ser Ala Asp  Arg Gln Gly Arg Arg  Gly Val Ser 
    1895                 1900                 1905             


Gly Ser  Gln Ala Ser Asp Ser  Glu Gly His Ser Asp  Phe Ser Glu 
    1910                 1915                 1920             


Gly Gln  Ala Val Gly Ala His  Arg Gln Ser Gly Ala  Gly Gln Arg 
    1925                 1930                 1935             


His Glu  Gln Arg Ser Ser Arg  Gly Gln His Gly Ser  Gly Tyr Tyr 
    1940                 1945                 1950             


Tyr Glu  Gln Glu His Ser Glu  Glu Glu Ser Asp Ser  Gln His Gln 
    1955                 1960                 1965             


His Gly  His Gln His Glu Gln  Gln Arg Gly His Gln  His Gln His 
    1970                 1975                 1980             


Gln His  Gln His Glu His Glu  Gln Pro Glu Ser Gly  His Arg Gln 
    1985                 1990                 1995             


Gln Gln  Phe Ser Gly Arg Gly  His Gln Gly Ala His  Gln Glu Gln 
    2000                 2005                 2010             


Gly Arg  Asp Ser Ala Arg Ser  Arg Gly Ser Asn Gln  Gly His Ser 
    2015                 2020                 2025             


Ser Ser  Arg His Gln Ala Asp  Ser Pro Arg Val Ser  Ala Arg Ser 
    2030                 2035                 2040             


Gly Ser  Gly Gly Arg Gly Gln  Ser Pro Asp Ala Ser  Gly Arg Ser 
    2045                 2050                 2055             


Ser Asn  Arg Arg Asp Arg Pro  Arg Gln Pro Ser Pro  Ser Gln Ser 
    2060                 2065                 2070             


Ser Asp  Ser Gln Val His Ser  Gly Val Gln Val Glu  Gly Arg Arg 
    2075                 2080                 2085             


Gly Gln  Ser Ser Ser Ala Asn  Arg Arg Ala Gly Ser  Ser Ser Ser 
    2090                 2095                 2100             


Ser Gly  Val Gln Gly Ala Ser  Ala Gly Gly Leu Ala  Ala Asp Ala 
    2105                 2110                 2115             


Ser Arg  Arg Ser Gly Ala Arg  Gln Gly Gln Ala Ser  Ala Gln Gly 
    2120                 2125                 2130             


Arg Ala  Gly Ser Gln Gly Gln  Ala Gln Gly Arg Val  Gly Ser Ser 
    2135                 2140                 2145             


Ala Asp  Arg Gln Gly Arg Arg  Gly Val Ser Glu Ser  Gln Ala Ser 
    2150                 2155                 2160             


Asp Ser  Glu Gly His Ser Asp  Phe Ser Glu Gly Gln  Ala Val Gly 
    2165                 2170                 2175             


Ala His  Arg Gln Ser Gly Ala  Gly Gln Arg His Glu  Gln Arg Ser 
    2180                 2185                 2190             


Ser Arg  Gly Gln His Gly Ser  Gly Phe Tyr Pro Val  Tyr Tyr Tyr 
    2195                 2200                 2205             


Tyr Glu  Gln Glu His Ser Glu  Glu Glu Ser Asp Ser  Gln His Gln 
    2210                 2215                 2220             


His Gly  His Gln His Glu Gln  Gln Arg Gly His Gln  His Gln His 
    2225                 2230                 2235             


Gln His  Gln His Glu His Glu  Gln Pro Glu Ser Gly  His Arg Gln 
    2240                 2245                 2250             


Gln Gln  Phe Ser Gly Arg Gly  His Gln Gly Ala His  Gln Glu Gln 
    2255                 2260                 2265             


Gly Arg  Asp Ser Ala Arg Ser  Arg Gly Ser Asn Gln  Gly His Ser 
    2270                 2275                 2280             


Ser Ser  Arg His Gln Ala Asp  Ser Pro Arg Val Ser  Ala Arg Ser 
    2285                 2290                 2295             


Gly Ser  Gly Gly Arg Gly Gln  Ser Pro Asp Ala Ser  Gly Arg Ser 
    2300                 2305                 2310             


Ser Asn  Arg Arg Asp Arg Pro  Arg Gln Pro Ser Pro  Ser Gln Ser 
    2315                 2320                 2325             


Ser Asp  Ser Gln Val His Ser  Gly Val Gln Val Glu  Gly Arg Arg 
    2330                 2335                 2340             


Gly Gln  Ser Ser Ser Ala Asn  Arg Arg Ala Gly Ser  Ser Ser Gly 
    2345                 2350                 2355             


Ser Gly  Val Gln Gly Ala Ser  Ala Gly Gly Leu Ala  Ala Asp Ala 
    2360                 2365                 2370             


Ser Arg  Arg Ser Gly Ala Arg  Gln Gly Gln Ala Ser  Ala Gln Gly 
    2375                 2380                 2385             


Arg Ala  Gly Ser Gln Gly Gln  Ala Gln Gly Arg Val  Gly Ser Ser 
    2390                 2395                 2400             


Ala Asp  Arg Gln Gly Arg Arg  Gly Val Ser Glu Ser  Gln Ala Ser 
    2405                 2410                 2415             


Asp Ser  Glu Gly His Ser Asp  Phe Ser Glu Gly Gln  Ala Val Gly 
    2420                 2425                 2430             


Ala His  Arg Gln Ser Gly Ala  Gly Gln Arg His Glu  Gln Arg Ser 
    2435                 2440                 2445             


Ser Arg  Gly Gln His Gly Ser  Gly Tyr Tyr Tyr Glu  Gln Glu His 
    2450                 2455                 2460             


Ser Glu  Glu Glu Ser Asp Ser  Gln His Gln Gln Gly  His Gln His 
    2465                 2470                 2475             


Glu Gln  Gln Arg Gly His Gln  His Gln His Gln His  Gln His Glu 
    2480                 2485                 2490             


His Glu  Gln Pro Glu Ser Gly  His Arg Gln Gln Gln  Ser Ser Gly 
    2495                 2500                 2505             


Arg Gly  His Gln Gly Ala His  Gln Glu Gln Gly Arg  Asp Ser Ala 
    2510                 2515                 2520             


Arg Ser  Arg Gly Ser Asn Gln  Gly His Ser Ser Ser  Arg His Gln 
    2525                 2530                 2535             


Ala Asp  Ser Pro Arg Val Ser  Ala Arg Ser Gly Ser  Gly Gly Arg 
    2540                 2545                 2550             


Gly Gln  Ser Pro Asp Gly Ser  Gly Arg Ser Ser Asn  Arg Arg Asp 
    2555                 2560                 2565             


Arg Pro  Arg Gln Pro Ser Ala  Ser Gln Ser Ser Asp  Ser Gln Val 
    2570                 2575                 2580             


His Ser  Gly Val Gln Val Glu  Ala Gln Arg Gly Gln  Ser Ser Ser 
    2585                 2590                 2595             


Ala Asn  Arg Arg Ala Gly Ser  Ser Ser Gly Ser Gly  Val Gln Ser 
    2600                 2605                 2610             


Ala Ala  Ala Ser Gly Gln Gly  Gly Tyr Glu Ser Ile  Phe Thr Ala 
    2615                 2620                 2625             


Lys His  Leu Asp Phe Asn Gln  Ser His Ser Tyr Tyr  Tyr Tyr 
    2630                 2635                 2640         


<210> 17
<211> 336
<212> PRT
<213> Mus musculus

<400> 17
Pro Asp Gly Ser Gly Arg Ser Ser Asn Arg Arg Asp Arg Pro Arg Gln 
1               5                   10                  15      


Leu Ser Pro Ser Gln Ser Ser Asp Ser Gln Val His Ser Gly Val Gln 
            20                  25                  30          


Val Glu Gly Arg Arg Gly His Ser Ser Ser Ala Asn Arg Arg Ala Gly 
        35                  40                  45              


Ser Ser Ser Gly Ser Gly Val Gln Gly Ala Ser Ala Gly Gly Leu Ala 
    50                  55                  60                  


Ala Asp Ala Ser Arg Arg Ser Gly Ala Arg Gln Gly Gln Ala Ser Ala 
65                  70                  75                  80  


Gln Gly Arg Ala Gly Ser Gln Gly Gln Ala Gln Gly Arg Val Ser Ser 
                85                  90                  95      


Ser Ala Asp Arg Gln Gly Arg Arg Gly Val Ser Glu Ser Arg Ala Ser 
            100                 105                 110         


Asp Ser Glu Gly His Ser Asp Phe Ser Glu Gly Gln Ala Val Gly Ala 
        115                 120                 125             


His Arg Gln Ser Gly Ala Gly Gln Arg His Glu Gln Arg Ser Ser Arg 
    130                 135                 140                 


Gly Gln His Gly Ser Gly Tyr Tyr Tyr Glu Gln Glu His Ser Glu Glu 
145                 150                 155                 160 


Glu Ser Asp Ser Gln His Gln His Gly His Gln His Glu Gln Gln Arg 
                165                 170                 175     


Gly His Gln His Gln His Gln His Gln His Glu His Glu Gln Pro Glu 
            180                 185                 190         


Ser Gly His Arg Gln Gln Gln Ser Ser Gly Arg Gly His Gln Gly Ala 
        195                 200                 205             


His Gln Glu Gln Gly Arg Asp Ser Ala Arg Pro Arg Gly Ser Asn Gln 
    210                 215                 220                 


Gly His Ser Ser Ser Arg His Gln Ala Asp Ser Pro Arg Val Ser Ala 
225                 230                 235                 240 


Arg Ser Gly Ser Gly Gly Arg Gly Gln Ser Pro Asp Ala Ser Gly Arg 
                245                 250                 255     


Ser Ser Asn Arg Arg Asp Arg Pro Arg Gln Pro Ser Pro Ser Gln Ser 
            260                 265                 270         


Ser Asp Ser Gln Val His Ser Gly Val Gln Val Glu Ala Gln Arg Gly 
        275                 280                 285             


Gln Ser Ser Ser Ala Asn Arg Arg Ala Gly Ser Ser Ser Gly Ser Gly 
    290                 295                 300                 


Val Gln Gly Ala Ala Ala Ser Gly Gln Gly Gly Tyr Glu Ser Ile Phe 
305                 310                 315                 320 


Thr Ala Lys His Leu Asp Phe Asn Gln Ser His Ser Tyr Tyr Tyr Tyr 
                325                 330                 335     


<210> 18
<211> 357
<212> PRT
<213> Mus musculus

<400> 18
Met Ser Ala Leu Leu Glu Ser Ile Thr Ser Met Ile Glu Ile Phe Gln 
1               5                   10                  15      


Gln Tyr Ser Thr Ser Asp Lys Glu Glu Glu Thr Leu Ser Lys Glu Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Gly Gln Leu Gln Ala Val Leu Lys Asn Pro 
        35                  40                  45              


Asp Asp Gln Asp Ile Ala Glu Val Phe Met Gln Met Leu Asp Val Asp 
    50                  55                  60                  


His Asp Asp Lys Leu Asp Phe Ala Glu Tyr Leu Leu Leu Val Leu Lys 
65                  70                  75                  80  


Leu Ala Lys Ala Tyr Tyr Glu Ala Ser Lys Asn Glu Ser Phe Gln Thr 
                85                  90                  95      


His Gly Ser Asn Gly Arg Ser Lys Thr Asp Tyr Lys Gly Leu Glu Glu 
            100                 105                 110         


Glu Gly Glu Glu Gly Asn Lys Gln Asn Leu Arg Arg Arg His Gly Gly 
        115                 120                 125             


Thr Asp Gly Lys Arg Lys Ser Asp Arg Thr Arg Ser Pro Asn Gly Lys 
    130                 135                 140                 


Arg Gly Lys Arg Gln Glu Ser Arg Cys Arg Ser Glu Gly Lys Asp Lys 
145                 150                 155                 160 


His Arg Arg Glu Pro Glu Lys His Arg His Gln Gln Asp Ser Lys Arg 
                165                 170                 175     


Lys Gln Arg His Gly Ser Gly Ser Thr Glu Arg Lys Asp Asn Arg Asn 
            180                 185                 190         


Lys Lys Asn Arg Gln Ser Lys Glu Arg Asn Tyr Asp Glu Ile Tyr Asp 
        195                 200                 205             


Asn Gly Lys Tyr Asn Glu Asp Trp Glu Ala Ser Tyr Asn Asn Cys Tyr 
    210                 215                 220                 


Tyr Lys Thr Gln Asn Thr Thr Leu Asp Gln Arg Glu Gly Asn Arg Arg 
225                 230                 235                 240 


Pro Arg Ala Asp Ser Gln Lys Glu Pro Gln Ser Ser His Gly Gln Ala 
                245                 250                 255     


Asp Asn Ser Asp Ser Glu Gly Gly Arg Gln Gln Ser His Ser Lys Pro 
            260                 265                 270         


Ser Pro Val Arg Ala Asp Gln Arg Arg Ser Arg Ala Gly Gln Ala Gly 
        275                 280                 285             


Ser Ser Lys Val Ser Ala Arg Ser Gly Ser Gly Gly Arg Gly Gln Ser 
    290                 295                 300                 


Pro Asp Gly Ser Gly Arg Ser Ser Asn Arg Arg Asp Arg Pro Arg Gln 
305                 310                 315                 320 


Pro Ser Pro Ser Gln Ser Ser Asp Ser Gln Val His Ser Gly Val Gln 
                325                 330                 335     


Val Glu Gly Arg Arg Gly Gln Ser Ser Ser Ala Asn Arg Arg Ala Gly 
            340                 345                 350         


Ser Ser Ser Gly Ser 
        355         


<210> 19
<211> 366
<212> PRT
<213> Rattus norvegicus

<400> 19
Met Ser Thr Leu Leu Glu Ser Ile Thr Ser Met Ile Asp Ile Phe Gln 
1               5                   10                  15      


Gln Tyr Ser Asn Asn Asp Lys Glu Glu Glu Thr Leu Ser Lys Glu Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Gly Glu Leu Gln Ala Val Leu Lys Asn Pro 
        35                  40                  45              


Asn Asp Gln Asp Ile Ala Glu Val Phe Met Gln Met Leu Asp Val Asp 
    50                  55                  60                  


His Asp Asp Lys Ile Asp Phe Thr Glu Tyr Leu Leu Met Val Leu Lys 
65                  70                  75                  80  


Leu Ala Gln Ala Tyr Tyr Glu Thr Ser Lys Lys Arg Arg Ser Gln Thr 
                85                  90                  95      


Lys Glu Ser Gly Lys Arg Asn Glu His Asp Tyr Lys Gly Tyr Glu Glu 
            100                 105                 110         


Arg Arg Glu Lys Val Gln Arg Arg His Arg Arg Arg Asn Ser Gly Thr 
        115                 120                 125             


Asp Gly Lys Gln Glu Asn Glu Arg Ser Lys Ser Pro Arg Gly Arg Gly 
    130                 135                 140                 


Asn Lys Arg Arg Gly Ser Ser Thr Ile Ser Glu Glu Ser Asp Thr Asn 
145                 150                 155                 160 


Arg Asn Ser Asp Thr Glu Asn Lys Arg His His His Gly Ser Asn Arg 
                165                 170                 175     


Arg Gln Arg Arg Gly Ser Asn Ser Ser Asp Arg Lys Glu Thr Arg Ser 
            180                 185                 190         


Lys Lys His Arg Glu Val Lys Glu Arg Asn Ala Gly Ile Tyr Asn Asp 
        195                 200                 205             


Gly Lys Asp Gly Gln Asp Trp Glu Val Asn Tyr Glu Asn Cys Tyr Tyr 
    210                 215                 220                 


Lys Thr Glu Glu Ser Asn Arg Glu Gln Arg Glu Gly Arg Asn His Lys 
225                 230                 235                 240 


Thr Lys Glu Ser His Ser Glu Ser Glu Ala Ser Gly Gly Gln Ala Gly 
                245                 250                 255     


Arg Arg Gly Thr Ala Ala Thr Arg His Thr Ser Arg Pro Glu Gln Ser 
            260                 265                 270         


Pro Asp Thr Ala Gly Arg Thr Gly Ser Ser Arg Gly Gln Gln Ser Ala 
        275                 280                 285             


Gln Arg His Ala Asp Ser Thr Pro Gly Ser Thr Arg Thr Gly Ser Arg 
    290                 295                 300                 


Gly Arg Gly Glu Ser Pro Ala Gly Gln Gln Ser Pro Asp Arg Ala Arg 
305                 310                 315                 320 


His Ile Glu Ser Arg Arg Gly Arg Thr Arg Glu Ala Ser Ala Ser Gln 
                325                 330                 335     


Ser Ser Asp Ser Glu Gly His Ser Gly Ala His Ala Gly Ile Gly Gln 
            340                 345                 350         


Gly Gln Thr Ser Thr Thr His Arg Arg Ala Gly Ser Ser Ser 
        355                 360                 365     


<210> 20
<211> 3088
<212> PRT
<213> Pan troglodytes

<400> 20
Met Ser Thr Leu Leu Glu Asn Ile Phe Ala Ile Ile Asn Leu Phe Lys 
1               5                   10                  15      


Gln Tyr Ser Lys Lys Asp Lys Asn Thr Asp Thr Leu Ser Lys Lys Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Lys Glu Phe Arg Gln Ile Leu Lys Asn Pro 
        35                  40                  45              


Asp Asp Pro Asp Met Val Asp Val Phe Met Asp His Leu Asp Ile Asp 
    50                  55                  60                  


His Asn Lys Lys Ile Asp Phe Thr Glu Phe Leu Leu Met Val Phe Lys 
65                  70                  75                  80  


Leu Ala Gln Ala Tyr Tyr Glu Ser Thr Arg Lys Glu Asn Leu Pro Ile 
                85                  90                  95      


Ser Gly His Lys His Arg Lys His Ser His His Asp Lys His Glu Asp 
            100                 105                 110         


Asn Lys Gln Glu Glu Asn Lys Glu Asn Arg Lys Arg Pro Ser Ser Leu 
        115                 120                 125             


Glu Arg Arg Asn Asn Arg Lys Gly Asn Lys Gly Arg Ser Lys Ser Pro 
    130                 135                 140                 


Arg Glu Thr Gly Gly Lys Arg His Glu Ser Ser Ser Glu Lys Lys Glu 
145                 150                 155                 160 


Arg Lys Gly Tyr Ser Pro Thr His Arg Glu Glu Glu Tyr Gly Lys Asn 
                165                 170                 175     


His His Asn Ser Ser Lys Lys Gln Lys Asn Lys Thr Glu Asn Thr Arg 
            180                 185                 190         


Leu Glu Asp Asn Arg Lys Arg Leu Ser Glu Arg Leu Glu Glu Lys Glu 
        195                 200                 205             


Asp Asn Glu Glu Gly Gly Tyr Asp Tyr Glu Asn Thr Gly Arg Met Thr 
    210                 215                 220                 


Gln Lys Trp Ile Gln Ser Gly His Ile Ala Thr Tyr Tyr Thr Ile Gln 
225                 230                 235                 240 


Asp Glu Ala Tyr Asp Thr Thr Asp Asn Leu Leu Glu Glu Asn Lys Ile 
                245                 250                 255     


Tyr Glu Arg Ser Arg Ser Ser Asp Asp Lys Ser Ser Ser Gln Val Asn 
            260                 265                 270         


Arg Ser Arg His Glu Asn Thr Ser Gln Val Pro Leu Gln Glu Ser Arg 
        275                 280                 285             


Thr Arg Lys Arg Arg Gly Ser Arg Val Ser Gln Asp Arg Asp Ser Glu 
    290                 295                 300                 


Gly His Ser Glu Asp Ser Glu Arg His Ser Gly Ser Ala Ser Arg Asn 
305                 310                 315                 320 


His Pro Gly Ser Ala Arg Gln Gln Ser Arg Asp Gly Ser Arg His Pro 
                325                 330                 335     


Arg Ser His Asp Glu Asp Arg Ala Ser His Gly His Ser Ala Asp Ser 
            340                 345                 350         


Ser Arg Gln Ser Gly Thr Arg His Ala Glu Thr Ser Ser Arg Gly Gln 
        355                 360                 365             


Thr Ala Ser Ser His Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg His 
    370                 375                 380                 


Gly Ser Arg His Gln Gln Ser Ala Asp Ser Ser Arg His Ser Ala Thr 
385                 390                 395                 400 


Gly Arg Gly Gln Ala Ser Ser Ala Val Ser Asp Arg Gly Pro Arg Gly 
                405                 410                 415     


Ser Ser Gly Ser Gln Ala Ser Asp Ser Glu Gly His Ser Glu Asn Ser 
            420                 425                 430         


Asp Thr Gln Ser Val Ser Gly His Gly Lys Ala Gly Pro Arg Gln Gln 
        435                 440                 445             


Ser His Gln Glu Ser Ala Arg Gly Arg Ser Gly Glu Arg Ser Gly His 
    450                 455                 460                 


Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Glu Gln Ser Asp Ser 
465                 470                 475                 480 


Ala His Gly Arg Thr Gly Thr Ser Thr Gly Gly Arg Gln Gly Ser His 
                485                 490                 495     


His Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala Ser Gln Glu Gly 
            500                 505                 510         


Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg Gly Gly Arg Gln 
        515                 520                 525             


Gly Ser His His Glu Gln Leu Val Asn Arg Ser Gly His Ser Gly Ser 
    530                 535                 540                 


His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp Ala Ser His Gly 
545                 550                 555                 560 


Gln Ser Gly Ser Arg Ser Ala Ser Arg Gln Thr Arg Asn Glu Glu Gln 
                565                 570                 575     


Ser Gly Asp Gly Ser Arg His Ser Gly Ser Arg His His Glu Ala Ser 
            580                 585                 590         


Ser Gln Ala Asp Ser Ser Arg His Ser Gln Val Gly Gln Gly Gln Ser 
        595                 600                 605             


Ser Gly Pro Arg Thr Ser Ser His Gln Gly Ser Ser Val Ser Gln Asp 
    610                 615                 620                 


Ser Asp Ser Glu Gly His Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser 
625                 630                 635                 640 


Ala Ser Arg Asn His His Gly Ser Ala Arg Glu Gln Ser Arg Asp Gly 
                645                 650                 655     


Ser Arg His Pro Arg Ser His His Glu Asp Arg Ala Gly His Gly His 
            660                 665                 670         


Ser Ala Asp Ser Ser Arg Gln Ser Gly Thr Arg His Thr Glu Ser Ser 
        675                 680                 685             


Ser Arg Gly Gln Ala Val Ser Ser His Glu Gln Ala Arg Ser Ser Pro 
    690                 695                 700                 


Gly Glu Arg His Gly Ser Arg His Gln Gln Ser Ala Asp Ser Ser Arg 
705                 710                 715                 720 


His Ser Gly Ile Gly His Gly Gln Ala Ser Ser Ala Val Arg Asp Ser 
                725                 730                 735     


Gly His Arg Gly Ser Ser Gly Ser Gln Ala Ile Asp Ser Glu Gly His 
            740                 745                 750         


Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Ser His Gly Gln Ala Gly 
        755                 760                 765             


Pro His Gln Gln Ser His Lys Glu Ser Ala Arg Gly Gln Ser Gly Glu 
    770                 775                 780                 


Ser Ser Gly Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Ser His Glu 
785                 790                 795                 800 


Gln Ser Glu Ser Thr Tyr Gly Gln Thr Ala Pro Ser Thr Gly Gly Arg 
                805                 810                 815     


Gln Gly Ser Arg His Glu Gln Ala Arg Asn Ser Ser Arg His Ser Ala 
            820                 825                 830         


Ser Gln Asp Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg 
        835                 840                 845             


Gly Gly Arg Gln Gly Ser Tyr His Glu Gln Ser Val Asp Arg Ser Gly 
    850                 855                 860                 


His Ser Gly Tyr His His Ser His Thr Thr Pro Gln Gly Arg Ser Asp 
865                 870                 875                 880 


Ala Ser His Gly Gln Ser Gly Pro Arg Ser Ala Ser Arg Gln Thr Arg 
                885                 890                 895     


Asn Glu Glu Gln Ser Gly Asp Gly Ser Arg His Ser Gly Ser Arg His 
            900                 905                 910         


His Glu Pro Ser Thr Arg Ala Ser Ser Ser Arg His Ser Gln Val Gly 
        915                 920                 925             


Gln Gly Glu Ser Ala Val Ser Lys Thr Ser Arg Arg Gln Gly Ser Ser 
    930                 935                 940                 


Val Ser Gln Asp Arg Asp Ser Glu Gly His Ser Glu Asp Ser Glu Arg 
945                 950                 955                 960 


Gln Ser Glu Ser Ala Ser Arg Asn His Tyr Gly Ser Ala Arg Glu Gln 
                965                 970                 975     


Ser Arg His Gly Ser Arg Asn Pro Arg Ser His Gln Glu Asp Arg Ala 
            980                 985                 990         


Ser His Gly His Ser Ala Glu Ser  Ser Arg Gln Ser Gly  Thr His His 
        995                 1000                 1005             


Ala Glu  Thr Ser Ser His Gly  Gln Ala Ala Ser Ser  Gln Glu Gln 
    1010                 1015                 1020             


Ala Arg  Ser Ser Arg Gly Glu  Arg His Gly Ser Arg  His Gln Gln 
    1025                 1030                 1035             


Ser Ala  Asp Ser Ser Thr Asp  Ser Gly Thr Gly Gly  Arg Gln Ala 
    1040                 1045                 1050             


Ser Ser  Val Val Gly Asp Ser  Gly Asn Arg Gly Ser  Ser Gly Ser 
    1055                 1060                 1065             


Gln Ala  Ser Asp Ser Glu Gly  His Ser Glu Asp Ser  Asp Thr Gln 
    1070                 1075                 1080             


Ser Val  Ser Ala His Gly Gln  Ala Gly Pro Arg Gln  Gln Ser His 
    1085                 1090                 1095             


Gln Glu  Ser Thr Arg Gly Gln  Ser Gly Glu Arg Ser  Gly Arg Ser 
    1100                 1105                 1110             


Gly Ser  Phe Leu Tyr Gln Val  Ser Thr His Glu Gln  Ser Glu Ser 
    1115                 1120                 1125             


Ala His  Gly Arg Thr Gly Pro  Ser Thr Gly Gly Arg  Gln Arg Ser 
    1130                 1135                 1140             


Arg His  Glu Gln Ala Arg Asp  Ser Ser Arg His Ser  Ala Ser Gln 
    1145                 1150                 1155             


Glu Ser  Gln Asp Ile Ile His  Ala His Pro Gly Ser  Ser Arg Gly 
    1160                 1165                 1170             


Gly Arg  Gln Gly Ser His Tyr  Glu Gln Ser Val Asp  Arg Ser Gly 
    1175                 1180                 1185             


His Ser  Gly Ser His His Ser  His Thr Thr Ser Gln  Glu Arg Ser 
    1190                 1195                 1200             


Asn Ala  Ser His Gly Gln Ser  Gly Ser Arg Ser Ala  Ser Arg Gln 
    1205                 1210                 1215             


Thr Arg  Asn Glu Glu Gln Ser  Gly Asp Gly Ser Arg  His Ser Gly 
    1220                 1225                 1230             


Ser Arg  His His Glu Ala Ser  Ser Arg Ala Asp Ser  Ser Arg His 
    1235                 1240                 1245             


Ser Gln  Val Gly Gln Gly Gln  Ser Ser Gly Pro Arg  Thr Ser Arg 
    1250                 1255                 1260             


Asn Gln  Gly Ser Ser Val Ser  Gln Asp Ser Asp Ser  Gln Gly His 
    1265                 1270                 1275             


Ser Glu  Asp Ser Glu Arg Trp  Ser Gly Ser Ala Ser  Arg Asn His 
    1280                 1285                 1290             


His Gly  Ser Ala Trp Glu Gln  Ser Arg Asp Gly Ser  Arg His Pro 
    1295                 1300                 1305             


Gly Ser  His Gln Glu Asp Arg  Ala Gly His Gly His  Ser Ala Asp 
    1310                 1315                 1320             


Ser Ser  Arg Gln Ser Gly Thr  His His Thr Glu Ser  Ser Ser Arg 
    1325                 1330                 1335             


Gly Gln  Ala Ala Ser Ser His  Glu His Ala Arg Ser  Ser Ala Gly 
    1340                 1345                 1350             


Glu Arg  His Gly Ser His His  Gln Gln Ser Ala Asp  Ser Ser Arg 
    1355                 1360                 1365             


His Ser  Gly Ile Gly His Gly  Gln Ala Ser Ser Ala  Val Arg Asp 
    1370                 1375                 1380             


Ser Gly  His Arg Gly Ser Ser  Gly Ser Gln Ala Ser  Asp Ser Glu 
    1385                 1390                 1395             


Gly His  Ser Glu Asp Ser Asp  Thr Gln Ser Leu Ser  Ala His Gly 
    1400                 1405                 1410             


Gln Ala  Gly Pro His Gln Gln  Ser His Gln Glu Ser  Thr Arg Gly 
    1415                 1420                 1425             


Arg Ser  Ala Glu Arg Ser Gly  Arg Ser Gly Ser Phe  Leu Tyr Gln 
    1430                 1435                 1440             


Val Ser  Thr His Glu Gln Ser  Glu Ser Ala His Gly  Arg Thr Gly 
    1445                 1450                 1455             


Thr Ser  Thr Gly Gly Arg Lys  Arg Ser Leu His Glu  Gln Ala Arg 
    1460                 1465                 1470             


Asp Ser  Ser Arg His Ser Val  Ser Gln Glu Gly Gln  Asp Thr Ile 
    1475                 1480                 1485             


His Gly  His Ala Gly Ser Ser  Ser Gly Gly Arg Gln  Gly Ser His 
    1490                 1495                 1500             


Tyr Glu  Gln Leu Val Asp Arg  Ser Gly His Ser Gly  Ser His His 
    1505                 1510                 1515             


Ser His  Thr Thr Ser Gln Gly  Arg Ser Asp Ala Tyr  His Gly Gln 
    1520                 1525                 1530             


Ser Gly  Ser Arg Ser Ala Ser  Arg Gln Thr His Asn  Asp Glu Gln 
    1535                 1540                 1545             


Ser Gly  Asp Gly Phe Arg His  Ser Gly Ser His His  His Glu Ala 
    1550                 1555                 1560             


Ser Ser  Arg Ala Asp Ser Ser  Arg His Ser Gln Val  Gly Gln Gly 
    1565                 1570                 1575             


Gln Ser  Glu Gly Pro Arg Thr  Ser Arg His Arg Glu  Ser Ser Val 
    1580                 1585                 1590             


Ser Gln  Asp Ser Asp Ser Glu  Gly His Ser Glu Asp  Ser Glu Arg 
    1595                 1600                 1605             


Trp Ser  Gly Ser Ala Ser Arg  Asn His His Gly Ser  Ala Arg Glu 
    1610                 1615                 1620             


Gln Ser  Arg Asp Gly Ser Arg  His Pro Arg Ser His  His Glu Asp 
    1625                 1630                 1635             


Arg Ala  Gly His Gly His Ser  Ala Asp Ser Ser Arg  Gln Ser Gly 
    1640                 1645                 1650             


Thr Arg  His Thr Gln Thr Ser  Ser Gly Gly Gln Ala  Ala Ser Ser 
    1655                 1660                 1665             


His Glu  Gln Gly Arg Ser Ser  Ala Gly Glu Arg His  Gly Ser Arg 
    1670                 1675                 1680             


His Gln  Gln Ser Ala Asp Ser  Ser Arg His Ser Gly  Ile Gly His 
    1685                 1690                 1695             


Gly Gln  Ala Ser Ser Ala Val  Arg Asp Ser Gly His  Arg Gly Tyr 
    1700                 1705                 1710             


Ser Gly  Ser Gln Ala Ser Asp  Ser Glu Gly His Ser  Glu Asp Ser 
    1715                 1720                 1725             


Asp Thr  Gln Ser Val Ser Ala  His Gly Gln Ala Gly  Ser His Gln 
    1730                 1735                 1740             


Gln Ser  His Gln Glu Ser Ala  Arg Gly Arg Ser Gly  Glu Arg Ser 
    1745                 1750                 1755             


Gly Arg  Ser Gly Ser Phe Leu  Tyr Gln Val Ser Thr  His Glu Gln 
    1760                 1765                 1770             


Ser Glu  Ser Ser His Gly Trp  Thr Gly Pro Ser Thr  Arg Gly Arg 
    1775                 1780                 1785             


Gln Gly  Ser Arg His Glu Gln  Ala Gln Asp Ser Ser  Arg His Ser 
    1790                 1795                 1800             


Ala Ser  Gln Glu Gly Gln Asp  Thr Ile Arg Gly His  Pro Gly Pro 
    1805                 1810                 1815             


Ser Arg  Gly Gly Arg Gln Gly  Tyr His His Glu Gln  Ser Val Asp 
    1820                 1825                 1830             


Ser Ser  Gly His Ser Gly Ser  His His Ser His Ile  Thr Ser Gln 
    1835                 1840                 1845             


Gly Ser  Ser His Ala Ser His  Gly Gln Ser Gly Ser  Arg Ser Ala 
    1850                 1855                 1860             


Ser Arg  Thr Thr Arg Asn Asp  Glu Gln Ser Val Asp  Gly Ser Arg 
    1865                 1870                 1875             


His Ser  Gly Ser Arg His His  Glu Ala Ser Thr His  Ala Asp Ile 
    1880                 1885                 1890             


Ser Arg  His Ser Gln Ala Gly  Gln Gly Gln Ser Glu  Gly Ser Arg 
    1895                 1900                 1905             


Thr Ser  Arg Arg Gln Gly Ser  Ser Val Ser Gln Asp  Ser Asp Ser 
    1910                 1915                 1920             


Glu Gly  His Ser Glu Asp Ser  Glu Arg Trp Ser Gly  Ser Ala Ser 
    1925                 1930                 1935             


Arg Asn  His Arg Gly Ser Ala  Gln Glu Gln Ser Arg  Asp Gly Ser 
    1940                 1945                 1950             


Arg His  Pro Arg Ser His His  Glu Asp Arg Ala Gly  His Gly His 
    1955                 1960                 1965             


Ser Ala  Asp Ser Ser Arg Gln  Ser Gly Thr His His  Ala Glu Thr 
    1970                 1975                 1980             


Ser Ser  Gly Gly Gln Ala Ala  Ser Ser Arg Glu Gln  Ala Arg Ser 
    1985                 1990                 1995             


Ser Pro  Gly Glu Arg His Gly  Ser Arg His Gln Gln  Ser Ala Asp 
    2000                 2005                 2010             


Ser Ser  Arg His Ser Gly Ile  Arg Arg Gly Gln Ala  Ser Ser Ala 
    2015                 2020                 2025             


Val Arg  Asp Ser Gly His Trp  Gly Ser Ser Gly Ser  Gln Ala Ser 
    2030                 2035                 2040             


Asp Ser  Glu Gly His Ser Glu  Glu Ser Asp Thr Gln  Ser Val Ser 
    2045                 2050                 2055             


Gly His  Gly Gln Asp Gly Pro  His Gln Gln Ser His  Gln Glu Ser 
    2060                 2065                 2070             


Ala Arg  Asp Arg Ser Gly Gly  Arg Ser Gly Arg Ser  Gly Ser Phe 
    2075                 2080                 2085             


Leu Tyr  Gln Val Ser Thr His  Glu Gln Ser Glu Ser  Thr His Gly 
    2090                 2095                 2100             


Gln Thr  Gly Thr Ser Thr Gly  Gly Arg Gln Gly Ser  His His Glu 
    2105                 2110                 2115             


Gln Ala  Arg Asp Ser Ser Arg  His Ser Ala Ser Gln  Glu Gly Gln 
    2120                 2125                 2130             


Asp Thr  Ile His Ala His Pro  Gly Ser Ser Arg Gly  Gly Arg Gln 
    2135                 2140                 2145             


Gly Ser  His His Glu Gln Ser  Val Asp Thr Ser Gly  His Ser Gly 
    2150                 2155                 2160             


Ser His  His Ser His Thr Thr  Ser Gln Gly Arg Ser  Asp Ala Ser 
    2165                 2170                 2175             


His Gly  Gln Ser Gly Ser Arg  Ser Ala Ser Arg Gln  Thr Arg Asn 
    2180                 2185                 2190             


Asp Glu  Gln Ser Gly Asp Gly  Ser Arg His Ser Gly  Ser His His 
    2195                 2200                 2205             


His Glu  Ala Phe Thr Gln Ala  Asp Ser Ser Arg His  Ser Gln Ser 
    2210                 2215                 2220             


Gly Gln  Gly Glu Ser Ala Gly  Ser Arg Arg Ser Arg  Arg Gln Gly 
    2225                 2230                 2235             


Ser Ser  Val Ser Gln Asp Ser  Asp Ser Gln Gly His  Ser Glu Asp 
    2240                 2245                 2250             


Ser Glu  Arg Trp Ser Gly Ser  Ala Ser Arg Asn Gln  His Gly Ser 
    2255                 2260                 2265             


Ala Arg  Glu Gln Ser Arg Asp  Gly Ser Arg His Pro  Gly Ser His 
    2270                 2275                 2280             


Gln Glu  Asp Arg Ala Gly His  Gly His Ser Ala Asp  Ser Ser Arg 
    2285                 2290                 2295             


Gln Ser  Gly Thr Arg His Thr  Glu Ser Ser Ser Arg  Gly Gln Ala 
    2300                 2305                 2310             


Ala Ser  Ser His Glu Gln Ala  Arg Ser Ser Ala Gly  Glu Arg His 
    2315                 2320                 2325             


Gly Ser  Arg His Gln Leu Gln  Ser Ala Asp Ser Ser  Arg His Ser 
    2330                 2335                 2340             


Gly Ile  Gly His Gly Gln Ala  Ser Ser Ala Val Arg  Asp Ser Gly 
    2345                 2350                 2355             


His Arg  Gly Ser Ser Gly Ser  Gln Ala Ile Asp Ser  Glu Gly His 
    2360                 2365                 2370             


Ser Glu  Asp Ser Asp Thr Gln  Ser Val Ser Ala Gln  Gly Gln Ala 
    2375                 2380                 2385             


Gly Pro  His Gln Arg Ser His  Lys Glu Ser Ala Arg  Gly Gln Ser 
    2390                 2395                 2400             


Gly Glu  Ser Ser Gly Arg Ser  Gly Ser Phe Leu Tyr  Gln Val Ser 
    2405                 2410                 2415             


Thr His  Glu Gln Pro Glu Ser  Thr His Gly Gln Ser  Ala Pro Ser 
    2420                 2425                 2430             


Thr Gly  Gly Arg Gln Gly Ser  His His Asp Gln Ala  Gln Asp Ser 
    2435                 2440                 2445             


Ser Arg  His Ser Ala Ser Gln  Glu Gly Gln Asp Thr  Ile Arg Gly 
    2450                 2455                 2460             


His Pro  Gly Pro Ser Arg Gly  Gly Arg Gln Gly Ser  His His Lys 
    2465                 2470                 2475             


Gln Ser  Val Asp Arg Ser Gly  His Ser Gly Ser His  His Ser His 
    2480                 2485                 2490             


Thr Thr  Ser Gln Gly Arg Ser  Asp Ala Ser Arg Gly  Gln Ser Gly 
    2495                 2500                 2505             


Ser Arg  Ser Ala Ser Arg Gln  Thr His Asp Lys Glu  Gln Ser Gly 
    2510                 2515                 2520             


Asp Gly  Ser Arg His Ser Gly  Ser Arg His His Glu  Ala Ser Ser 
    2525                 2530                 2535             


Trp Ala  Asp Ser Ser Arg His  Ser Gln Ala Gly Gln  Gly Gln Ser 
    2540                 2545                 2550             


Glu Gly  Ser Arg Thr Ser Arg  Arg Gln Gly Ser Ser  Phe Ser Gln 
    2555                 2560                 2565             


Asp Ser  Asp Ser Glu Gly His  Ser Glu Asp Ser Glu  Arg Arg Ser 
    2570                 2575                 2580             


Gly Ser  Ala Ser Arg Asn His  Arg Gly Ser Ala Gln  Glu Gln Ser 
    2585                 2590                 2595             


Arg Asp  Gly Ser Arg His Pro  Arg Ser His His Glu  Asp Arg Ala 
    2600                 2605                 2610             


Gly His  Gly His Ser Ala Asp  Ser Ser Arg Gln Ser  Gly Thr His 
    2615                 2620                 2625             


His Ala  Gln Asn Ser Ser Gly  Gly Gln Ala Ala Ser  Phe His Glu 
    2630                 2635                 2640             


Gln Ala  Arg Ser Ser Ala Gly  Glu Arg His Gly Ser  His His Gln 
    2645                 2650                 2655             


Gln Ser  Ala Asp Ser Ser Arg  His Ser Gly Ile Gly  His Gly Gln 
    2660                 2665                 2670             


Ala Ser  Ser Ala Val Arg Asp  Ser Gly His Arg Gly  Ser Ser Gly 
    2675                 2680                 2685             


Ser Gln  Ala Ser Asp Ser Glu  Gly His Ser Glu Asp  Ser Asp Thr 
    2690                 2695                 2700             


Gln Ser  Val Ser Ala His Gly  Gln Ala Gly Pro His  Gln Gln Ser 
    2705                 2710                 2715             


His Gln  Glu Ser Thr Arg Gly  Arg Ser Ala Glu Arg  Ser Gly Arg 
    2720                 2725                 2730             


Ser Gly  Ser Phe Leu Tyr Gln  Val Ser Thr His Glu  Gln Ser Glu 
    2735                 2740                 2745             


Ser Ala  His Gly Arg Thr Gly  Pro Ser Thr Gly Gly  Arg Gln Gly 
    2750                 2755                 2760             


Ser Arg  His Glu Gln Ala Arg  Asp Ser Ser Arg His  Ser Ala Ser 
    2765                 2770                 2775             


Gln Glu  Gly Gln Asp Thr Ile  His Gly His Pro Gly  Ser Arg Arg 
    2780                 2785                 2790             


Gly Gly  Arg Gln Gly Ser Tyr  His Glu Gln Ser Val  Asp Arg Ser 
    2795                 2800                 2805             


Gly His  Ser Gly Ser His His  Ser His Thr Thr Ser  Gln Gly Arg 
    2810                 2815                 2820             


Ser Asp  Ala Ser His Gly Gln  Ser Gly Ser Arg Ser  Ala Ser Arg 
    2825                 2830                 2835             


Gln Thr  Arg Asn Glu Gln Gln  Ser Gly Asp Gly Ser  Arg His Ser 
    2840                 2845                 2850             


Gly Ser  Ser His His Glu Ala  Ser Thr Gln Ala Asp  Ser Ser Arg 
    2855                 2860                 2865             


His Ser  Gln Ser Gly Gln Gly  Glu Ser Ala Gly Ser  Arg Arg Ser 
    2870                 2875                 2880             


Arg Arg  Gln Gly Ser Ser Val  Ser Gln Asp Ser Asp  Ser Glu Ala 
    2885                 2890                 2895             


Tyr Pro  Glu Asp Ser Glu Arg  Arg Ser Glu Ser Ala  Ser Arg Asn 
    2900                 2905                 2910             


Arg His  Gly Ser Ser Arg Glu  Gln Ser Arg Asp Gly  Ser Arg His 
    2915                 2920                 2925             


Pro Gly  Ser Ser His Arg Asp  Thr Thr Arg His Val  Gln Ser Ser 
    2930                 2935                 2940             


Pro Val  Gln Ser Asp Ser Ser  Thr Ala Lys Glu His  Gly His Phe 
    2945                 2950                 2955             


Ser Ser  Leu Ser Gln Asp Ser  Ala Tyr Arg Ser Gly  Ile Gln Ser 
    2960                 2965                 2970             


Arg Gly  Ser Pro His Ser Ser  Ser Ser Tyr His Tyr  Gln Ser Glu 
    2975                 2980                 2985             


Gly Thr  Glu Arg Gln Lys Gly  Gln Ser Gly Leu Val  Trp Arg His 
    2990                 2995                 3000             


Gly Ser  Tyr Gly Ser Ala Asp  Tyr Asp Tyr Gly Glu  Ser Gly Phe 
    3005                 3010                 3015             


Arg His  Ser Gln His Gly Ser  Val Ser Tyr Asn Ser  Asn Pro Val 
    3020                 3025                 3030             


Val Phe  Lys Glu Arg Ser Asp  Ile Cys Lys Ala Ser  Ala Phe Gly 
    3035                 3040                 3045             


Lys Asp  His Pro Arg Tyr Tyr  Ala Thr Tyr Ile Asn  Lys Asp Pro 
    3050                 3055                 3060             


Gly Leu  Cys Gly His Ser Ser  Asp Ile Ser Lys Gln  Leu Gly Phe 
    3065                 3070                 3075             


Ser Gln  Ser Gln Arg Tyr Tyr  Tyr Tyr Glu 
    3080                 3085             


<210> 21
<211> 2764
<212> PRT
<213> Pan troglodytes

<400> 21
Met Ser Thr Leu Leu Glu Asn Ile Phe Ala Ile Ile Asn Leu Phe Lys 
1               5                   10                  15      


Gln Tyr Ser Lys Lys Asp Lys Asn Thr Asp Thr Leu Ser Lys Lys Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Lys Glu Phe Arg Gln Ile Leu Lys Asn Pro 
        35                  40                  45              


Asp Asp Pro Asp Met Val Asp Val Phe Met Asp His Leu Asp Ile Asp 
    50                  55                  60                  


His Asn Lys Lys Ile Asp Phe Thr Glu Phe Leu Leu Met Val Phe Lys 
65                  70                  75                  80  


Leu Ala Gln Ala Tyr Tyr Glu Ser Thr Arg Lys Glu Asn Leu Pro Ile 
                85                  90                  95      


Ser Gly His Lys His Arg Lys His Ser His His Asp Lys His Glu Asp 
            100                 105                 110         


Asn Lys Gln Glu Glu Asn Lys Glu Asn Arg Lys Arg Pro Ser Ser Leu 
        115                 120                 125             


Glu Arg Arg Asn Asn Arg Lys Gly Asn Lys Gly Arg Ser Lys Ser Pro 
    130                 135                 140                 


Arg Glu Thr Gly Gly Lys Arg His Glu Ser Ser Ser Glu Lys Lys Glu 
145                 150                 155                 160 


Arg Lys Gly Tyr Ser Pro Thr His Arg Glu Glu Glu Tyr Gly Lys Asn 
                165                 170                 175     


His His Asn Ser Ser Lys Lys Gln Lys Asn Lys Thr Glu Asn Thr Arg 
            180                 185                 190         


Leu Glu Asp Asn Arg Lys Arg Leu Ser Glu Arg Leu Glu Glu Lys Glu 
        195                 200                 205             


Asp Asn Glu Glu Gly Gly Tyr Asp Tyr Glu Asn Thr Gly Arg Met Thr 
    210                 215                 220                 


Gln Lys Trp Ile Gln Ser Gly His Ile Ala Thr Tyr Tyr Thr Ile Gln 
225                 230                 235                 240 


Asp Glu Ala Tyr Asp Thr Thr Asp Asn Leu Leu Glu Glu Asn Lys Ile 
                245                 250                 255     


Tyr Glu Arg Ser Arg Ser Ser Asp Asp Lys Ser Ser Ser Gln Val Asn 
            260                 265                 270         


Arg Ser Arg His Glu Asn Thr Ser Gln Val Pro Leu Gln Glu Ser Arg 
        275                 280                 285             


Thr Arg Lys Arg Arg Gly Ser Arg Val Ser Gln Asp Arg Asp Ser Glu 
    290                 295                 300                 


Gly His Ser Glu Asp Ser Glu Arg His Ser Gly Ser Ala Ser Arg Asn 
305                 310                 315                 320 


His Pro Gly Ser Ala Arg Gln Gln Ser Arg Asp Gly Ser Arg His Pro 
                325                 330                 335     


Arg Ser His Asp Glu Asp Arg Ala Ser His Gly His Ser Ala Asp Ser 
            340                 345                 350         


Ser Arg Gln Ser Gly Thr Arg His Ala Glu Thr Ser Ser Arg Gly Gln 
        355                 360                 365             


Thr Ala Ser Ser His Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg His 
    370                 375                 380                 


Gly Ser Arg His Gln Gln Ser Ala Asp Ser Ser Arg His Ser Ala Thr 
385                 390                 395                 400 


Gly Arg Gly Gln Ala Ser Ser Ala Val Ser Asp Arg Gly Pro Arg Gly 
                405                 410                 415     


Ser Ser Gly Ser Gln Ala Ser Asp Ser Glu Gly His Ser Glu Asn Ser 
            420                 425                 430         


Asp Thr Gln Ser Val Ser Gly His Gly Lys Ala Gly Pro Arg Gln Gln 
        435                 440                 445             


Ser His Gln Glu Ser Ala Arg Gly Arg Ser Gly Glu Arg Ser Gly His 
    450                 455                 460                 


Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Glu Gln Ser Asp Ser 
465                 470                 475                 480 


Ala His Gly Arg Thr Gly Thr Ser Thr Gly Gly Arg Gln Gly Ser His 
                485                 490                 495     


His Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala Ser Gln Glu Gly 
            500                 505                 510         


Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg Gly Gly Arg Gln 
        515                 520                 525             


Gly Ser His His Glu Gln Leu Val Asn Arg Ser Gly His Ser Gly Ser 
    530                 535                 540                 


His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp Ala Ser His Gly 
545                 550                 555                 560 


Gln Ser Gly Ser Arg Ser Ala Ser Arg Gln Thr Arg Asn Glu Glu Gln 
                565                 570                 575     


Ser Gly Asp Gly Ser Arg His Ser Gly Ser Arg His His Glu Ala Ser 
            580                 585                 590         


Ser Gln Ala Asp Ser Ser Arg His Ser Gln Val Gly Gln Gly Gln Ser 
        595                 600                 605             


Ser Gly Pro Arg Thr Ser Ser His Gln Gly Ser Ser Val Ser Gln Asp 
    610                 615                 620                 


Ser Asp Ser Glu Gly His Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser 
625                 630                 635                 640 


Ala Ser Arg Asn His His Gly Ser Ala Arg Glu Gln Ser Arg Asp Gly 
                645                 650                 655     


Ser Arg His Pro Arg Ser His His Glu Asp Arg Ala Gly His Gly His 
            660                 665                 670         


Ser Ala Asp Ser Ser Arg Gln Ser Gly Thr Arg His Thr Glu Ser Ser 
        675                 680                 685             


Ser Arg Gly Gln Ala Val Ser Ser His Glu Gln Ala Arg Ser Ser Pro 
    690                 695                 700                 


Gly Glu Arg His Gly Ser Arg His Gln Gln Ser Ala Asp Ser Ser Arg 
705                 710                 715                 720 


His Ser Gly Ile Gly His Gly Gln Ala Ser Ser Ala Val Arg Asp Ser 
                725                 730                 735     


Gly His Arg Gly Ser Ser Gly Ser Gln Ala Ile Asp Ser Glu Gly His 
            740                 745                 750         


Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Ser His Gly Gln Ala Gly 
        755                 760                 765             


Pro His Gln Gln Ser His Lys Glu Ser Ala Arg Gly Gln Ser Gly Glu 
    770                 775                 780                 


Ser Ser Gly Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Ser His Glu 
785                 790                 795                 800 


Gln Ser Glu Ser Thr Tyr Gly Gln Thr Ala Pro Ser Thr Gly Gly Arg 
                805                 810                 815     


Gln Gly Ser Arg His Glu Gln Ala Arg Asn Ser Ser Arg His Ser Ala 
            820                 825                 830         


Ser Gln Asp Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg 
        835                 840                 845             


Gly Gly Arg Gln Gly Ser Tyr His Glu Gln Ser Val Asp Arg Ser Gly 
    850                 855                 860                 


His Ser Gly Tyr His His Ser His Thr Thr Pro Gln Gly Arg Ser Asn 
865                 870                 875                 880 


Ala Ser His Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Gln Thr Arg 
                885                 890                 895     


Asn Glu Glu Gln Ser Gly Asp Gly Ser Arg His Ser Gly Ser Arg His 
            900                 905                 910         


His Glu Ala Ser Ser Arg Ala Asp Ser Ser Arg His Ser Gln Val Gly 
        915                 920                 925             


Gln Gly Gln Ser Ser Gly Pro Arg Thr Ser Arg Asn Gln Gly Ser Ser 
    930                 935                 940                 


Val Ser Gln Asp Ser Asp Ser Gln Gly His Ser Glu Asp Ser Glu Arg 
945                 950                 955                 960 


Trp Ser Gly Ser Ala Ser Arg Asn His His Gly Ser Ala Trp Glu Gln 
                965                 970                 975     


Ser Arg Asp Gly Ser Arg His Pro Gly Ser His Gln Glu Asp Arg Ala 
            980                 985                 990         


Gly His Gly His Ser Ala Asp Ser  Ser Arg Gln Ser Gly  Thr His His 
        995                 1000                 1005             


Thr Glu  Ser Ser Ser Arg Gly  Gln Ala Ala Ser Ser  His Glu His 
    1010                 1015                 1020             


Ala Arg  Ser Ser Ala Gly Glu  Arg His Gly Ser His  His Gln Gln 
    1025                 1030                 1035             


Ser Ala  Asp Ser Ser Arg His  Ser Gly Ile Gly His  Gly Gln Ala 
    1040                 1045                 1050             


Ser Ser  Ala Val Arg Asp Ser  Gly His Arg Gly Ser  Ser Gly Ser 
    1055                 1060                 1065             


Gln Ala  Ser Asp Ser Glu Gly  His Ser Glu Asp Ser  Asp Thr Gln 
    1070                 1075                 1080             


Ser Leu  Ser Ala His Gly Gln  Ala Gly Pro His Gln  Gln Ser His 
    1085                 1090                 1095             


Gln Glu  Ser Thr Arg Gly Arg  Ser Ala Glu Arg Ser  Gly Arg Ser 
    1100                 1105                 1110             


Gly Ser  Phe Leu Tyr Gln Val  Ser Thr His Glu Gln  Ser Glu Ser 
    1115                 1120                 1125             


Ala His  Gly Arg Thr Gly Thr  Ser Thr Gly Gly Arg  Lys Arg Ser 
    1130                 1135                 1140             


Leu His  Glu Gln Ala Arg Asp  Ser Ser Arg His Ser  Val Ser Gln 
    1145                 1150                 1155             


Glu Gly  Gln Asp Thr Ile His  Gly His Ala Gly Ser  Ser Ser Gly 
    1160                 1165                 1170             


Gly Arg  Gln Gly Ser His Tyr  Glu Gln Leu Val Asp  Arg Ser Gly 
    1175                 1180                 1185             


His Ser  Gly Ser His His Ser  His Thr Thr Ser Gln  Gly Arg Ser 
    1190                 1195                 1200             


Asp Ala  Tyr His Gly Gln Ser  Gly Ser Arg Ser Ala  Ser Arg Gln 
    1205                 1210                 1215             


Thr His  Asn Asp Glu Gln Ser  Gly Asp Gly Phe Arg  His Ser Gly 
    1220                 1225                 1230             


Ser His  His His Glu Ala Ser  Ser Arg Ala Asp Ser  Ser Arg His 
    1235                 1240                 1245             


Ser Gln  Val Gly Gln Gly Gln  Ser Glu Gly Pro Arg  Thr Ser Arg 
    1250                 1255                 1260             


His Arg  Glu Ser Ser Val Ser  Gln Asp Ser Asp Ser  Glu Gly His 
    1265                 1270                 1275             


Ser Glu  Asp Ser Glu Arg Trp  Ser Gly Ser Ala Ser  Arg Asn His 
    1280                 1285                 1290             


His Gly  Ser Ala Arg Glu Gln  Ser Arg Asp Gly Ser  Arg His Pro 
    1295                 1300                 1305             


Arg Ser  His His Glu Asp Arg  Ala Gly His Gly His  Ser Ala Asp 
    1310                 1315                 1320             


Ser Ser  Arg Gln Ser Gly Thr  Arg His Thr Gln Thr  Ser Ser Gly 
    1325                 1330                 1335             


Gly Gln  Ala Ala Ser Ser His  Glu Gln Gly Arg Ser  Ser Ala Gly 
    1340                 1345                 1350             


Glu Arg  His Gly Ser Arg His  Gln Gln Ser Ala Asp  Ser Ser Arg 
    1355                 1360                 1365             


His Ser  Gly Ile Gly His Gly  Gln Ala Ser Ser Ala  Val Arg Asp 
    1370                 1375                 1380             


Ser Gly  His Arg Gly Tyr Ser  Gly Ser Gln Ala Ser  Asp Ser Glu 
    1385                 1390                 1395             


Gly His  Ser Glu Asp Ser Asp  Thr Gln Ser Val Ser  Ala His Gly 
    1400                 1405                 1410             


Gln Ala  Gly Ser His Gln Gln  Ser His Gln Glu Ser  Ala Arg Gly 
    1415                 1420                 1425             


Arg Ser  Gly Glu Arg Ser Gly  Arg Ser Gly Ser Phe  Leu Tyr Gln 
    1430                 1435                 1440             


Val Ser  Thr His Glu Gln Ser  Glu Ser Ser His Gly  Trp Thr Gly 
    1445                 1450                 1455             


Pro Ser  Thr Arg Gly Arg Gln  Gly Ser Arg His Glu  Gln Ala Gln 
    1460                 1465                 1470             


Asp Ser  Ser Arg His Ser Ala  Ser Gln Glu Gly Gln  Asp Thr Ile 
    1475                 1480                 1485             


Arg Gly  His Pro Gly Pro Ser  Arg Gly Gly Arg Gln  Gly Tyr His 
    1490                 1495                 1500             


His Glu  Gln Ser Val Asp Ser  Ser Gly His Ser Gly  Ser His His 
    1505                 1510                 1515             


Ser His  Ile Thr Ser Gln Gly  Ser Ser His Ala Ser  His Gly Gln 
    1520                 1525                 1530             


Ser Gly  Ser Arg Ser Ala Ser  Arg Thr Thr Arg Asn  Asp Glu Gln 
    1535                 1540                 1545             


Ser Val  Asp Gly Ser Arg His  Ser Gly Ser Arg His  His Glu Ala 
    1550                 1555                 1560             


Ser Thr  His Ala Asp Ile Ser  Arg His Ser Gln Ala  Gly Gln Gly 
    1565                 1570                 1575             


Gln Ser  Glu Gly Ser Arg Thr  Ser Arg Arg Gln Gly  Ser Ser Val 
    1580                 1585                 1590             


Ser Gln  Asp Ser Asp Ser Glu  Gly His Ser Glu Asp  Ser Glu Arg 
    1595                 1600                 1605             


Trp Ser  Gly Ser Ala Ser Arg  Asn His Arg Gly Ser  Ala Gln Glu 
    1610                 1615                 1620             


Gln Ser  Arg Asp Gly Ser Arg  His Pro Arg Ser His  His Glu Asp 
    1625                 1630                 1635             


Arg Ala  Gly His Gly His Ser  Ala Asp Ser Ser Arg  Gln Ser Gly 
    1640                 1645                 1650             


Thr His  His Ala Glu Thr Ser  Ser Gly Gly Gln Ala  Ala Ser Ser 
    1655                 1660                 1665             


Arg Glu  Gln Ala Arg Ser Ser  Pro Gly Glu Arg His  Gly Ser Arg 
    1670                 1675                 1680             


His Gln  Gln Ser Ala Asp Ser  Ser Arg His Ser Gly  Ile Arg Arg 
    1685                 1690                 1695             


Gly Gln  Ala Ser Ser Ala Val  Arg Asp Ser Gly His  Trp Gly Ser 
    1700                 1705                 1710             


Ser Gly  Ser Gln Ala Ser Asp  Ser Glu Gly His Ser  Glu Glu Ser 
    1715                 1720                 1725             


Asp Thr  Gln Ser Val Ser Gly  His Gly Gln Asp Gly  Pro His Gln 
    1730                 1735                 1740             


Gln Ser  His Gln Glu Ser Ala  Arg Asp Arg Ser Gly  Gly Arg Ser 
    1745                 1750                 1755             


Gly Arg  Ser Gly Ser Phe Leu  Tyr Gln Val Ser Thr  His Glu Gln 
    1760                 1765                 1770             


Ser Glu  Ser Thr His Gly Gln  Thr Gly Thr Ser Thr  Gly Gly Arg 
    1775                 1780                 1785             


Gln Gly  Ser His His Glu Gln  Ala Arg Asp Ser Ser  Arg His Ser 
    1790                 1795                 1800             


Ala Ser  Gln Glu Gly Gln Asp  Thr Ile His Ala His  Pro Gly Ser 
    1805                 1810                 1815             


Ser Arg  Gly Gly Arg Gln Gly  Ser His His Glu Gln  Ser Val Asp 
    1820                 1825                 1830             


Thr Ser  Gly His Ser Gly Ser  His His Ser His Thr  Thr Ser Gln 
    1835                 1840                 1845             


Gly Arg  Ser Asp Ala Ser His  Gly Gln Ser Gly Ser  Arg Ser Ala 
    1850                 1855                 1860             


Ser Arg  Gln Thr Arg Asn Asp  Glu Gln Ser Gly Asp  Gly Ser Arg 
    1865                 1870                 1875             


His Ser  Gly Ser His His His  Glu Ala Phe Thr Gln  Ala Asp Ser 
    1880                 1885                 1890             


Ser Arg  His Ser Gln Ser Gly  Gln Gly Glu Ser Ala  Gly Ser Arg 
    1895                 1900                 1905             


Arg Ser  Arg Arg Gln Gly Ser  Ser Val Ser Gln Asp  Ser Asp Ser 
    1910                 1915                 1920             


Gln Gly  His Ser Glu Asp Ser  Glu Arg Trp Ser Gly  Ser Ala Ser 
    1925                 1930                 1935             


Arg Asn  Gln His Gly Ser Ala  Arg Glu Gln Ser Arg  Asp Gly Ser 
    1940                 1945                 1950             


Arg His  Pro Gly Ser His Gln  Glu Asp Arg Ala Gly  His Gly His 
    1955                 1960                 1965             


Ser Ala  Asp Ser Ser Arg Gln  Ser Gly Thr Arg His  Thr Glu Ser 
    1970                 1975                 1980             


Ser Ser  Arg Gly Gln Ala Ala  Ser Ser His Glu Gln  Ala Arg Ser 
    1985                 1990                 1995             


Ser Ala  Gly Glu Arg His Gly  Ser Arg His Gln Leu  Gln Ser Ala 
    2000                 2005                 2010             


Asp Ser  Ser Arg His Ser Gly  Ile Gly His Gly Gln  Ala Ser Ser 
    2015                 2020                 2025             


Ala Val  Arg Asp Ser Gly His  Arg Gly Ser Ser Gly  Ser Gln Ala 
    2030                 2035                 2040             


Ile Asp  Ser Glu Gly His Ser  Glu Asp Ser Asp Thr  Gln Ser Val 
    2045                 2050                 2055             


Ser Ala  Gln Gly Gln Ala Gly  Pro His Gln Arg Ser  His Lys Glu 
    2060                 2065                 2070             


Ser Ala  Arg Gly Gln Ser Gly  Glu Ser Ser Gly Arg  Ser Gly Ser 
    2075                 2080                 2085             


Phe Leu  Tyr Gln Val Ser Thr  His Glu Gln Pro Glu  Ser Thr His 
    2090                 2095                 2100             


Gly Gln  Ser Ala Pro Ser Thr  Gly Gly Arg Gln Gly  Ser His His 
    2105                 2110                 2115             


Asp Gln  Ala Gln Asp Ser Ser  Arg His Ser Ala Ser  Gln Glu Gly 
    2120                 2125                 2130             


Gln Asp  Thr Ile Arg Gly His  Pro Gly Pro Ser Arg  Gly Gly Arg 
    2135                 2140                 2145             


Gln Gly  Ser His His Lys Gln  Ser Val Asp Arg Ser  Gly His Ser 
    2150                 2155                 2160             


Gly Ser  His His Ser His Thr  Thr Ser Gln Gly Arg  Ser Asp Ala 
    2165                 2170                 2175             


Ser Arg  Gly Gln Ser Gly Ser  Arg Ser Ala Ser Arg  Gln Thr His 
    2180                 2185                 2190             


Asp Lys  Glu Gln Ser Gly Asp  Gly Ser Arg His Ser  Gly Ser Arg 
    2195                 2200                 2205             


His His  Glu Ala Ser Ser Trp  Ala Asp Ser Ser Arg  His Ser Gln 
    2210                 2215                 2220             


Ala Gly  Gln Gly Gln Ser Glu  Gly Ser Arg Thr Ser  Arg Arg Gln 
    2225                 2230                 2235             


Gly Ser  Ser Phe Ser Gln Asp  Ser Asp Ser Glu Gly  His Ser Glu 
    2240                 2245                 2250             


Asp Ser  Glu Arg Arg Ser Gly  Ser Ala Ser Arg Asn  His Arg Gly 
    2255                 2260                 2265             


Ser Ala  Gln Glu Gln Ser Arg  Asp Gly Ser Arg His  Pro Arg Ser 
    2270                 2275                 2280             


His His  Glu Asp Arg Ala Gly  His Gly His Ser Ala  Asp Ser Ser 
    2285                 2290                 2295             


Arg Gln  Ser Gly Thr His His  Ala Gln Asn Ser Ser  Gly Gly Gln 
    2300                 2305                 2310             


Ala Ala  Ser Phe His Glu Gln  Ala Arg Ser Ser Ala  Gly Glu Arg 
    2315                 2320                 2325             


His Gly  Ser His His Gln Gln  Ser Ala Asp Ser Ser  Arg His Ser 
    2330                 2335                 2340             


Gly Ile  Gly His Gly Gln Ala  Ser Ser Ala Val Arg  Asp Ser Gly 
    2345                 2350                 2355             


His Arg  Gly Ser Ser Gly Ser  Gln Ala Ser Asp Ser  Glu Gly His 
    2360                 2365                 2370             


Ser Glu  Asp Ser Asp Thr Gln  Ser Val Ser Ala His  Gly Gln Ala 
    2375                 2380                 2385             


Gly Pro  His Gln Gln Ser His  Gln Glu Ser Thr Arg  Gly Arg Ser 
    2390                 2395                 2400             


Ala Glu  Arg Ser Gly Arg Ser  Gly Ser Phe Leu Tyr  Gln Val Ser 
    2405                 2410                 2415             


Thr His  Glu Gln Ser Glu Ser  Ala His Gly Arg Thr  Gly Pro Ser 
    2420                 2425                 2430             


Thr Gly  Gly Arg Gln Gly Ser  Arg His Glu Gln Ala  Arg Asp Ser 
    2435                 2440                 2445             


Ser Arg  His Ser Ala Ser Gln  Glu Gly Gln Asp Thr  Ile His Gly 
    2450                 2455                 2460             


His Pro  Gly Ser Arg Arg Gly  Gly Arg Gln Gly Ser  Tyr His Glu 
    2465                 2470                 2475             


Gln Ser  Val Asp Arg Ser Gly  His Ser Gly Ser His  His Ser His 
    2480                 2485                 2490             


Thr Thr  Ser Gln Gly Arg Ser  Asp Ala Ser His Gly  Gln Ser Gly 
    2495                 2500                 2505             


Ser Arg  Ser Ala Ser Arg Gln  Thr Arg Asn Glu Gln  Gln Ser Gly 
    2510                 2515                 2520             


Asp Gly  Ser Arg His Ser Gly  Ser Ser His His Glu  Ala Ser Thr 
    2525                 2530                 2535             


Gln Ala  Asp Ser Ser Arg His  Ser Gln Ser Gly Gln  Gly Glu Ser 
    2540                 2545                 2550             


Ala Gly  Ser Arg Arg Ser Arg  Arg Gln Gly Ser Ser  Val Ser Gln 
    2555                 2560                 2565             


Asp Ser  Asp Ser Glu Ala Tyr  Pro Glu Asp Ser Glu  Arg Arg Ser 
    2570                 2575                 2580             


Glu Ser  Ala Ser Arg Asn Arg  His Gly Ser Ser Arg  Glu Gln Ser 
    2585                 2590                 2595             


Arg Asp  Gly Ser Arg His Pro  Gly Ser Ser His Arg  Asp Thr Thr 
    2600                 2605                 2610             


Arg His  Val Gln Ser Ser Pro  Val Gln Ser Asp Ser  Ser Thr Ala 
    2615                 2620                 2625             


Lys Glu  His Gly His Phe Ser  Ser Leu Ser Gln Asp  Ser Ala Tyr 
    2630                 2635                 2640             


Arg Ser  Gly Ile Gln Ser Arg  Gly Ser Pro His Ser  Ser Ser Ser 
    2645                 2650                 2655             


Tyr His  Tyr Gln Ser Glu Gly  Thr Glu Arg Gln Lys  Gly Gln Ser 
    2660                 2665                 2670             


Gly Leu  Val Trp Arg His Gly  Ser Tyr Gly Ser Ala  Asp Tyr Asp 
    2675                 2680                 2685             


Tyr Gly  Glu Ser Gly Phe Arg  His Ser Gln His Gly  Ser Val Ser 
    2690                 2695                 2700             


Tyr Asn  Ser Asn Pro Val Val  Phe Lys Glu Arg Ser  Asp Ile Cys 
    2705                 2710                 2715             


Lys Ala  Ser Ala Phe Gly Lys  Asp His Pro Arg Tyr  Tyr Ala Thr 
    2720                 2725                 2730             


Tyr Ile  Asn Lys Asp Pro Gly  Leu Cys Gly His Ser  Ser Asp Ile 
    2735                 2740                 2745             


Ser Lys  Gln Leu Gly Phe Ser  Gln Ser Gln Arg Tyr  Tyr Tyr Tyr 
    2750                 2755                 2760             


Glu 
    


<210> 22
<211> 819
<212> PRT
<213> Bos taurus

<400> 22
Met Ser Thr Leu Leu Glu Asn Ile Asn Asp Ile Ile Lys Ile Phe His 
1               5                   10                  15      


Lys Tyr Ser Lys Thr Asp Lys Glu Thr Asp Thr Leu Ser Glu Lys Glu 
            20                  25                  30          


Leu Lys Glu Leu Val Glu Val Glu Phe Arg Pro Ile Leu Lys Asn Pro 
        35                  40                  45              


Gly Asp Pro Asp Thr Ala Glu Val Phe Met Tyr Asn Leu Asp Arg Asp 
    50                  55                  60                  


His Asn Asn Lys Ile Asp Phe Thr Glu Phe Phe Leu Met Val Phe Lys 
65                  70                  75                  80  


Val Ala Gln Val Tyr Tyr Ser Tyr Thr Gln Arg Gln Asn Leu Gln Arg 
                85                  90                  95      


Ala Gly Gln Lys Gln Lys Lys Cys Thr Tyr His Tyr Gly Asp Glu Glu 
            100                 105                 110         


Asp Asp Thr Glu Glu Asp Lys Glu Glu Thr Glu Arg Lys Tyr Ser His 
        115                 120                 125             


Ser Arg Ser Asp Gly Lys Thr Gln Asp Arg Ser Lys Ser Pro Arg Gly 
    130                 135                 140                 


Arg Gly Lys Lys Arg His Gly Ser Lys Ser Gly Ser Lys Gln Arg Arg 
145                 150                 155                 160 


Gly Asp Thr Pro Thr Ser Gly Leu Arg His Gly Cys Ser Lys Lys His 
                165                 170                 175     


Glu Ser Arg Arg Glu Lys Lys Arg Arg Pro Ser Ser Thr Glu Pro Lys 
            180                 185                 190         


Glu Arg Arg His Met Ser Ser Val Ser Pro Thr Arg Gly Tyr Glu Glu 
        195                 200                 205             


Lys Glu Glu Glu His Gly Tyr Glu Asn Lys Gly Lys Thr Ser Ala Lys 
    210                 215                 220                 


Cys Ile Gly Ser Glu Tyr Asp Asp Ser Tyr Gln Val Cys Glu Asp Lys 
225                 230                 235                 240 


Val Thr Thr Asn Phe Gln Pro Ser His Ser Lys Asn Tyr Gly Ser Asn 
                245                 250                 255     


Ile Thr Lys Gly Arg Asp Thr Glu Gly His Ser Arg Asp Thr Gly Arg 
            260                 265                 270         


Lys Ser Val Phe Thr His Ala Arg Ser Gly Ser Ser Ser Arg Asn Gln 
        275                 280                 285             


Asn Gly Ser Val Gln Thr His Thr Gly Asp Asn Ser Thr His Ser Glu 
    290                 295                 300                 


Ser Gln Gln Glu Thr Asn Ser Glu Ser Val His Arg Arg Ser Arg Asn 
305                 310                 315                 320 


Thr Gly Gln Arg Gln Gly Ser His His Glu Gln Ser Arg Asp Ser Ser 
                325                 330                 335     


Arg His Ser Gly Thr Arg His Gly Gln Pro Ser Thr Gly Ser Gly Gly 
            340                 345                 350         


Ser Arg His Arg Glu Ser Ser Val Ser Gln Ala Ser Asp Ser Glu Gly 
        355                 360                 365             


His Ser Glu Asp Ser Gly Arg Gln Ser Val Thr Thr His Gly Arg Pro 
    370                 375                 380                 


Gly Ser Ser Ser Arg Asn Gln His Gly Ser Ser Gln Gly Gln Thr Gly 
385                 390                 395                 400 


Asp Ser Ser Arg His Ser Glu Ser His Gln Gly Arg His Ser Asp Ser 
                405                 410                 415     


Leu Gln Arg Arg Ser Gly Thr Ser Thr Gly Gln Arg Gln Gly Ser His 
            420                 425                 430         


His Glu Gln Ser Arg Asp Ser Ser Arg His Ser Gly Thr Gln Gln Gly 
        435                 440                 445             


Gln Thr Ser Thr Gly Ser Gly Ser Ser Arg His Arg Asp Ser Ser Val 
    450                 455                 460                 


Ser Gln Ala Ser Asp Ser Glu Gly His Ser Glu Asp Ser Gly Arg Gln 
465                 470                 475                 480 


Leu Glu Thr Val Leu Gly Ile Gln Ser Pro Ile Lys Glu Ala Thr Val 
                485                 490                 495     


Lys Leu Phe Met Lys Gly Gln Asp Pro Ala Arg Gly Lys Gly Arg Gly 
            500                 505                 510         


Ala Thr Met Ser Ser Gln Gly Thr Ala Pro Asp Thr Leu Glu Leu Asp 
        515                 520                 525             


Met Asp Lys Ser Gln Leu Asn Leu Glu Met Ala Asp Ile Gly Asn Pro 
    530                 535                 540                 


Val Leu Val Lys Pro Val Thr Val Arg Asp Thr Pro Glu Ile Gln Val 
545                 550                 555                 560 


Gly Ile Leu Arg Gln Leu Met Glu Asp Met Val Pro Ala Gln Gly Thr 
                565                 570                 575     


Asn Met Asp Pro Pro Met Val Arg Gln Gly Thr Val Ile Gly Thr Gln 
            580                 585                 590         


Arg Pro Ile Lys Gly Asp Thr Ile Arg Asp Thr Gln Glu Ile Gln Val 
        595                 600                 605             


Gly Ile Leu Arg Gln Leu Met Glu Asp Leu Val Pro Ala Gln Glu Thr 
    610                 615                 620                 


Asn Met Asp Leu Pro Met Ala Arg Val Glu Thr Val Leu Gly Thr Gln 
625                 630                 635                 640 


Ser Pro Ile Lys Arg Gly Ile Val Asn Leu Ser Met Glu Gly Gln Asp 
                645                 650                 655     


Pro Ala Leu Gly Lys Asp Arg Gly Ala Thr Met Ser Ser Gln Glu Thr 
            660                 665                 670         


Ala Pro Asp Thr Leu Glu Leu Asp Met Gly Lys Pro Gln Leu Asn Leu 
        675                 680                 685             


Glu Met Ala Asp Ile Gly Asn Pro Val Leu Val Lys Pro Val Thr Val 
    690                 695                 700                 


Arg Asp Thr Pro Glu Ile Gln Val Gly Ile Leu Arg Gln Leu Met Glu 
705                 710                 715                 720 


Gly Leu Val Gln Ala Gln Glu Thr Asn Met Asp Leu Pro Arg Ala Arg 
                725                 730                 735     


Gln Glu Thr Val Leu Gly Thr Gln His Ile Ile Lys Gly Gly Thr Val 
            740                 745                 750         


Asn Leu Ser Met Lys Gly Gln Arg Leu Glu Leu Gly Lys Asp Arg Gly 
        755                 760                 765             


Ala Thr Met Ser Ser Gln Gly Thr Ala Pro Asp Ser Leu Glu Leu Asp 
    770                 775                 780                 


Met Asp Ile Pro Leu Leu Asp Leu Glu Met Ala Asp Ile Gly Asn Pro 
785                 790                 795                 800 


Val Leu Val Ser Gln Val Thr Glu Arg Asp Thr Gln Glu Ile Gln Val 
                805                 810                 815     


Asp Ser Pro 
            


<210> 23
<211> 1183
<212> PRT
<213> Macaca mulatta

<400> 23
Met Ser Thr Leu Leu Glu Asn Ile Phe Ala Ile Ile Asn Leu Phe Lys 
1               5                   10                  15      


Gln Tyr Ser Lys Lys Asp Lys Asn Thr Asp Thr Leu Ser Lys Lys Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Lys Glu Phe Arg Pro Ile Leu Lys Asn Pro 
        35                  40                  45              


Asp Asp Pro Asp Thr Val Glu Val Phe Met Asp His Leu Asp Ile Asp 
    50                  55                  60                  


His Asn Lys Lys Ile Asp Phe Thr Glu Phe Leu Leu Met Val Phe Lys 
65                  70                  75                  80  


Leu Ala Gln Ala Tyr Tyr Glu Ser Thr Arg Lys Gln Asn Leu Pro Ile 
                85                  90                  95      


Ala Gly His Lys His Arg Lys His Ser His His Asp Lys His Glu Asp 
            100                 105                 110         


Asn Lys Glu Glu Glu Asn Lys Glu Lys Arg Lys Arg Pro Leu Ser Leu 
        115                 120                 125             


Glu Arg Arg Asn Asn Arg Lys Gly Asn Thr Gly Arg Ser Lys Ser Pro 
    130                 135                 140                 


Arg Glu Arg Gly Gly Lys Arg His Glu Ser Ser Phe Glu Lys Lys Glu 
145                 150                 155                 160 


Arg Lys Gly Tyr Ser Pro Thr Tyr Glu Glu Glu Glu Tyr Gly Gln Asn 
                165                 170                 175     


His His Lys Ser Ser Lys Lys Glu Lys Asn Lys Thr Glu Ile Thr Arg 
            180                 185                 190         


Leu Glu His Glu Gly Lys Arg Ile Ser Glu Arg Pro Glu Lys Lys Glu 
        195                 200                 205             


Glu Lys Glu Asp Gly Gln Phe Asp Tyr Glu Asn Ala Gly Arg Met Asp 
    210                 215                 220                 


Glu Lys Trp Thr Glu Ser Gly His Ile Ala Ile Tyr His Ala Ile Gln 
225                 230                 235                 240 


Asp Glu Val Asp Asp Thr Thr Glu Asn Ile Leu Glu Glu Asn Arg Arg 
                245                 250                 255     


Tyr Glu Thr Ser Arg Ser Pro His Asp Lys Ser Ser Leu Arg Val Asn 
            260                 265                 270         


Arg Ser Pro Asn Ala Asn Thr Ser Gln Ile Pro Leu Val Glu Pro Arg 
        275                 280                 285             


Arg Arg Thr Arg Gln Arg Ser Ser Val Ser Gln Asp Ser Asp Ser Glu 
    290                 295                 300                 


Gly His Ser Glu Asp Ser Glu Arg Gln Ser Glu Ser Ala Ser Arg Asn 
305                 310                 315                 320 


His His Gly Ser Val Arg Glu Gln Ser Arg His Gly Ser Arg His Pro 
                325                 330                 335     


Gly Ser His His Glu Asp Arg Ala Gly His Gly His Ser Ala Asp Ser 
            340                 345                 350         


Ser Thr Gln Ser Gly Thr Arg His Thr Glu Thr Ser Ser Arg Gly Gln 
        355                 360                 365             


Ala Val Ser Ser His Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg His 
    370                 375                 380                 


Gly Ser Arg His Gln Gln Ser Ala Glu Ser Ser Arg His Ser Gly Ile 
385                 390                 395                 400 


Gly Arg Gly Gln Ala Ser Ser Ala Val Ser Asp Arg Gly His Gln Gly 
                405                 410                 415     


Pro Ser Gly Ser His Phe Ser Asp Ser Glu Gly His Ser Glu His Ser 
            420                 425                 430         


Asp Thr Gln Ser Val Ser Gly His Gly Gln Ala Gly Pro His Pro His 
        435                 440                 445             


Ser His Gln Glu Ser Ala Arg Gly Arg Ser Arg Glu Arg Ser Gly Arg 
    450                 455                 460                 


Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Glu Gln Ser Glu Ser 
465                 470                 475                 480 


Thr His Gly Arg Thr Gly Pro Ser Ser Ala Gly Arg Gln Gly Ser Arg 
                485                 490                 495     


Asn Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala Ser His Glu Val 
            500                 505                 510         


Gln Asp Thr Val His Gly His His Gly Ser Ser Arg Gly Arg Arg Gln 
        515                 520                 525             


Gly Ser His His Glu Gln Leu Val Asp Ser Ser Gly His Ser Gly Ser 
    530                 535                 540                 


His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp Ala Ser Arg Gly 
545                 550                 555                 560 


Glu Ser Gly Ala Arg Ser Ala Ser Arg Gln Thr Arg His Glu Glu Gln 
                565                 570                 575     


Ser Gly Asp Gly Ser Arg His Ser Gly Ser Arg His His Glu Ser Ser 
            580                 585                 590         


Asn Arg Ala Asp Ser Ser Arg His Ala Gln Ser Ser Gln Gly Gln Ser 
        595                 600                 605             


Ala Gly Phe Arg Thr Ser Thr Arg Arg Gly Ser Ser Val Ser Gln Asp 
    610                 615                 620                 


Ser Asp Ser Glu Gly His Ser Glu Asp Ser Glu Arg Gln Ser Glu Ser 
625                 630                 635                 640 


Ala Ser Arg Asn His His Gly Ser Val Arg Glu Gln Ser Arg His Gly 
                645                 650                 655     


Ser Gly His Ser Gly Ser His His Gln Asp Lys Val Gly His Arg Tyr 
            660                 665                 670         


Ser Gly Asp Ser Ser Arg Gln Ser Gly Thr His His Val Glu Thr Ser 
        675                 680                 685             


Ser His Gly Gln Ala Ala Ser Ser His Glu Gln Thr Arg Ser Ser Pro 
    690                 695                 700                 


Gly Glu Arg His Gly Ser His His Gln Gln Ser Ala Asp Ser Ser Arg 
705                 710                 715                 720 


His Ser Gly Thr Gly Arg Gly Gln Ala Ser Ser Ala Val Ser Asp Arg 
                725                 730                 735     


Gly His Gln Gly Pro Ser Gly Ser His Phe Ser Asp Ser Glu Gly His 
            740                 745                 750         


Ser Glu His Ser Asp Thr Gln Ser Val Ser Gly Gln Gly Gln Ala Gly 
        755                 760                 765             


Arg His Pro His Ser His Gln Glu Ser Ala Arg Gly Arg Ser Gly Glu 
    770                 775                 780                 


Arg Ser Gly Arg Ser Gly Ser Phe Val Tyr Gln Val Ser Thr His Glu 
785                 790                 795                 800 


Gln Ser Glu Ser Thr His Gly Arg Thr Gly Pro Ser Thr Gly Gly Arg 
                805                 810                 815     


Gln Gly Ser Arg Asn Glu Gln Ala Arg Asp Ser Ser Arg His Ser Val 
            820                 825                 830         


Ser His Glu Gly Gln Asp Thr Ile His Gly His His Gly Ser Ser Arg 
        835                 840                 845             


Gly Gly Arg Gln Gly Ser His His Glu Gln Ser Val Asp Ser Ser Gly 
    850                 855                 860                 


His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp 
865                 870                 875                 880 


Ala Ser Arg Gly Glu Ser Gly Ala Arg Ser Ala Ser Arg Gln Thr Arg 
                885                 890                 895     


His Glu Glu Gln Ser Gly Asp Gly Ser Arg His Ser Gly Ser Arg His 
            900                 905                 910         


His Glu Ala Ser Asn Arg Ala Asp Ser Ser Arg His Ala Gln Ser Gly 
        915                 920                 925             


Gln Gly Gln Ser Ala Gly Phe Arg Thr Ser Thr Arg Arg Gly Ser Ser 
    930                 935                 940                 


Val Ser Gln Asp Ser Asp Ser Glu Gly His Ser Glu Asp Ser Glu Arg 
945                 950                 955                 960 


Gln Ser Glu Ser Ala Ser Arg Asn His His Gly Ser Val Arg Glu Gln 
                965                 970                 975     


Ser Arg His Gly Ser Arg His Pro Gly Ser His His Glu Asp Arg Ala 
            980                 985                 990         


Gly His Gly His Ser Ala Asp Ser  Ser Arg Gln Ser Gly  Thr Arg His 
        995                 1000                 1005             


Thr Glu  Thr Ser Ser Arg Gly  Gln Ala Val Ser Ser  His Glu Gln 
    1010                 1015                 1020             


Ala Arg  Ser Ser Pro Gly Glu  Arg His Gly Ser Arg  His Gln Gln 
    1025                 1030                 1035             


Ser Ala  Glu Ser Ser Arg His  Ser Gly Ile Gly Arg  Gly Gln Ala 
    1040                 1045                 1050             


Ser Ser  Ala Val Ser Asp Arg  Gly His Gln Gly Pro  Ser Gly Ser 
    1055                 1060                 1065             


His Phe  Ser Asp Ser Glu Gly  His Ser Glu His Ser  Asp Thr Gln 
    1070                 1075                 1080             


Ser Val  Ser Gly His Gly Gln  Ala Gly Pro His Pro  His Ser His 
    1085                 1090                 1095             


Gln Glu  Ser Ala Arg Gly Arg  Ser Gly Glu Arg Ser  Gly Arg Ser 
    1100                 1105                 1110             


Gly Ser  Phe Leu Tyr Gln Val  Ser Thr His Glu Gln  Ser Glu Ser 
    1115                 1120                 1125             


Thr His  Gly Arg Thr Gly Pro  Ser Ser Ala Gly Arg  Gln Gly Ser 
    1130                 1135                 1140             


Arg Asn  Glu Gln Ala Arg Asp  Ser Ser Arg His Ser  Ala Ser His 
    1145                 1150                 1155             


Glu Val  Gln Asp Thr Val His  Gly His His Gly Ser  Ser Arg Gly 
    1160                 1165                 1170             


Gly Arg  Gln Gly Ser His His  Glu Gln Ser 
    1175                 1180             


<210> 24
<211> 2265
<212> PRT
<213> Macaca mulatta

<400> 24
Met Thr Asp Leu Leu Arg Ser Val Val Thr Val Ile Asp Val Phe Tyr 
1               5                   10                  15      


Lys Tyr Thr Lys Gln Asp Gly Glu Cys Gly Thr Leu Ser Lys Asp Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Lys Glu Phe His Pro Val Leu Lys Asn Pro 
        35                  40                  45              


Asp Asp Pro Asp Thr Val Asp Val Ile Met His Met Leu Asp Arg Asp 
    50                  55                  60                  


His Asp Arg Arg Leu Asp Phe Thr Glu Phe Leu Leu Met Ile Phe Lys 
65                  70                  75                  80  


Leu Thr Met Ala Cys Asn Lys Val Leu Ser Lys Glu Tyr Cys Lys Ala 
                85                  90                  95      


Ser Gly Ser Lys Lys His Arg Arg Gly His Arg His Gln Glu Glu Glu 
            100                 105                 110         


Ser Glu Thr Glu Glu Asp Glu Glu Asp Thr Pro Glu His Lys Ser Gly 
        115                 120                 125             


Tyr Arg His Ser Ser Trp Ser Glu Gly Glu Glu His Gly Tyr Ser Ser 
    130                 135                 140                 


Gly His Ser Arg Gly Thr Val Lys Arg Arg His Gly Ser Asn Ser Arg 
145                 150                 155                 160 


Arg Leu Gly Arg Gln Gly His Leu Ser Ser Ser Gly Asn Gln Glu Arg 
                165                 170                 175     


Ser Gln Lys Arg Tyr His Arg Ser Ser Ser Gly His Ser Trp Ser Ser 
            180                 185                 190         


Gly Lys Glu Arg His Gly Phe Ser Ser Gly Glu Leu Arg Glu Arg Ile 
        195                 200                 205             


Asn Lys Ser His Val Ser Pro Ser Arg Glu Phe Gly Glu Glu Tyr Glu 
    210                 215                 220                 


Ser Gly Ser Gly Ser Lys Ser Trp Glu Arg Lys Gly His Gly Gly Leu 
225                 230                 235                 240 


Ser Cys Gly Leu Glu Ile Ser Gly His Glu Ser Asn Ser Thr Gln Ser 
                245                 250                 255     


Arg Ser Ser Gly Gln Lys Leu Gly Ser Ser Arg Ser Cys Ser Gly Asp 
            260                 265                 270         


Ser Arg Arg Arg Ser His Ala Cys Gly Tyr Ser Asn Ser Ser Gly Cys 
        275                 280                 285             


Gly Arg Pro Gln Asn Ala Ser Asn Ser Cys Gln Ser His Arg Phe Gly 
    290                 295                 300                 


Gly Gln Val Asn Gln Ser Ser Tyr Ile Gln Ser Gly Cys Gln Ser Gly 
305                 310                 315                 320 


Ile Asn Gly Glu Gln Gly His Asp Cys Val Ser Gly Gly Gln Pro Ser 
                325                 330                 335     


Gly Cys Gly Gln Pro Glu Ser Asn Ser Cys Ser Gln Ser Tyr Ser Gln 
            340                 345                 350         


Arg Gly Tyr Gly Ala Arg Glu Asn Gly Gln Pro Gln Asn Cys Gly Gly 
        355                 360                 365             


Gln Gln Arg Thr Gly Ser Ser Gln Ser Ser Phe Cys Gly Gln Tyr Glu 
    370                 375                 380                 


Ser Gly Gly Ser Gln Ser Cys Ser Asn Gly Gln His Glu His Gly Ser 
385                 390                 395                 400 


Cys Gly Arg Phe Ser Asn Ser Ser Ser Ser Asn Glu Phe Ser Lys Cys 
                405                 410                 415     


Gly Lys His Arg Ser Gly Ser Gly Gln Phe Thr Ser Cys Glu Gln His 
            420                 425                 430         


Gly Thr Gly Leu Ser Gln Ser Ser Gly Phe Glu Gln Gln Val Ala Gly 
        435                 440                 445             


Ser Ser Gln Thr Cys Ser Gln Tyr Gly Ser Arg Ser Ser Gln Ser Ser 
    450                 455                 460                 


Gly Tyr Asp Glu His Gly Ser Ser Ser Gly Lys Thr Ser Gly Phe Gly 
465                 470                 475                 480 


Gln His Arg Ser Gly Ser Gly His Ser Ser Gly Phe Gly Gln His Gly 
                485                 490                 495     


Ser Gly Ser Gly Gln Ser Phe Gly Phe Gly Gln His Gly Ser Gly Ser 
            500                 505                 510         


Gly Gln Ser Ser Gly Phe Gly Gln His Glu Ser Arg Ser Cys Gln Ser 
        515                 520                 525             


Ser Tyr Gly Gln His Gly Ser Gly Ser Ser Gln Ser Ser Gly Tyr Gly 
    530                 535                 540                 


Gln His Ala Ser Arg Gln Thr Ser Gly Phe Gly Gln His Gly Leu Gly 
545                 550                 555                 560 


Ser Gly Gln Ser Thr Gly Phe Gly Gln Tyr Gly Ser Gly Ser Gly Gln 
                565                 570                 575     


Ser Ser Gly Phe Gly Gln His Gly Ser Gly Ser Gly Gln Ser Ser Gly 
            580                 585                 590         


Phe Gly Gln His Glu Ser Arg Ser Gly Gln Ser Ser Tyr Gly Gln His 
        595                 600                 605             


Ser Ser Ser Ser Ser Gln Ser Ser Gly Tyr Gly Gln His Gly Ser Arg 
    610                 615                 620                 


Gln Thr Ser Gly Phe Gly Gln His Gly Ser Gly Ser Gly Gln Ser Thr 
625                 630                 635                 640 


Gly Phe Gly Gln Tyr Gly Ser Ser Leu Gly Gln Ser Ser Gly Phe Gly 
                645                 650                 655     


Gln His Gly Ser Gly Ser Gly Gln Ser Ser Gly Phe Gly Gln His Glu 
            660                 665                 670         


Ser Thr Ser Gly Gln Ser Ser Tyr Gly Gln His Gly Phe Gly Ser Ser 
        675                 680                 685             


Gln Ser Ser Gly Cys Gly Gln His Gly Leu Ser Ser Gly Gln Thr Ser 
    690                 695                 700                 


Gly Phe Gly Gln His Glu Leu Ser Ser Gly Gln Ser Ser Ser Phe Gly 
705                 710                 715                 720 


Gln His Gly Ser Gly Ser Gly Gln Ser Ser Gly Phe Arg Gln His Glu 
                725                 730                 735     


Ser Gly Ser Gly Gln Ser Ser Gly Phe Gly Gln His Glu Ser Arg Ser 
            740                 745                 750         


His Gln Ser Ser Tyr Gly Pro His Gly Ser Gly Ser Gly Gln Ser Ser 
        755                 760                 765             


Gly Tyr Gly Gln His Gly Ser Ser Ser Gly Gln Thr Ser Gly Phe Gly 
    770                 775                 780                 


Gln Gln Gly Ser Ser Ser Ser Gln Tyr Ser Gly Phe Gly Gln His Gly 
785                 790                 795                 800 


Ser Gly Leu Gly Gln Ser Ser Gly Phe Gly Gln His Gly Thr Gly Ser 
                805                 810                 815     


Gly Gln Phe Ser Gly Phe Gly Gln His Glu Ser Arg Ser His Gln Ser 
            820                 825                 830         


Ser Tyr Gly Gln His Gly Ser Gly Ser Ser Gln Ser Ser Gly Tyr Gly 
        835                 840                 845             


Gln His Gly Ser Ser Ser Gly His Thr Thr Gly Phe Gly Gln His Arg 
    850                 855                 860                 


Ser Ser Ser Gly Gln Tyr Ser Gly Phe Gly Gln His Gly Ser Gly Leu 
865                 870                 875                 880 


Gly Gln Ser Ser Gly Phe Gly Gln His Gly Thr Gly Ser Gly Gln Ser 
                885                 890                 895     


Ser Gly Phe Gly Gln His Glu Ser Arg Ser His Gln Ser Ser Tyr Gly 
            900                 905                 910         


Gln His Gly Ser Gly Ser Ser Gln Ser Ser Ser Tyr Gly Gln His Gly 
        915                 920                 925             


Ser Ser Ser Gly Gln Thr Ser Gly Phe Gly Gln His Arg Ser Gly Ser 
    930                 935                 940                 


Gly Gln Ser Ser Gly Phe Gly Gln Tyr Gly Leu Gly Ser Gly Gln Ser 
945                 950                 955                 960 


Ser Gly Phe Gly Gln His Gly Ser Gly Thr Gly Gln Ser Ser Gly Phe 
                965                 970                 975     


Ala Arg His Glu Tyr Arg Ser Gly Gln Ser Ser Tyr Gly Gln His Gly 
            980                 985                 990         


Thr Gly Ser Ser Gln Ser Ser Gly  Cys Gly Gln Arg Glu  Ser Gly Ser 
        995                 1000                 1005             


Gly Pro  Thr Thr Gly Phe Gly  Gln His Val Ser Gly  Ser Asp Asn 
    1010                 1015                 1020             


Phe Ser  Ser Ser Gly Gln His  Ile Ser Gly Ser Asp  Gln Ser Thr 
    1025                 1030                 1035             


Gly Phe  Gly Gln Tyr Gly Ser  Gly Ser Gly Gln Ser  Thr Gly Leu 
    1040                 1045                 1050             


Gly Gln  Val Glu Ser Gln Gln  Val Ala Ser Gly Ser  Thr Val His 
    1055                 1060                 1065             


Gly Arg  Gln Glu Thr Thr His  Gly Gln Thr Ile Asn  Thr Ala Arg 
    1070                 1075                 1080             


His Ser  Gln Ser Gly Gln Gly  Gln Ser Thr Gln Thr  Gly Ser Arg 
    1085                 1090                 1095             


Val Ser  Arg Arg Arg Arg Ser  Ser Gln Ser Glu Asn  Ile Asp Ser 
    1100                 1105                 1110             


Glu Val  His Ser Arg Val Ser  His Arg His Ser Glu  His Ile Asp 
    1115                 1120                 1125             


Thr Gln  Val Gly Ser His Tyr  Pro Glu Ser Gly Ser  Thr Val His 
    1130                 1135                 1140             


Arg Arg  Gln Gly Thr Thr His  Gly Gln Arg Gly Asp  Thr Thr Arg 
    1145                 1150                 1155             


His Ser  His Ser Gly His Gly  Gln Ser Thr Gln Thr  Gly Ser Arg 
    1160                 1165                 1170             


Thr Thr  Gly Arg Gln Arg Phe  Ser His Ser Asp Ala  Thr Asp Ser 
    1175                 1180                 1185             


Glu Val  His Ser Gly Val Ser  His Arg Pro His Ser  Gln Glu His 
    1190                 1195                 1200             


Thr His  Gly Gln Asp Gly Ser  Gln Leu Gly Glu Ser  Gln Ser Thr 
    1205                 1210                 1215             


Val His  Glu Arg His Glu Thr  Thr Tyr Gly Gln Thr  Gly Asp Ala 
    1220                 1225                 1230             


Thr Gly  His Gly Tyr Ser Gly  His Gly Gln Ser Thr  Gln Ile Gly 
    1235                 1240                 1245             


Ser Arg  Thr Ser Gly Arg Arg  Gly Ser Gly His Ser  Glu Ser Ser 
    1250                 1255                 1260             


Asp Thr  Glu Val His Ser Gly  Gly Ser His Arg Pro  His Ser Gln 
    1265                 1270                 1275             


Glu Gln  Thr His Gly Gln Ala  Arg Ser Gln His Gly  Glu Ser Arg 
    1280                 1285                 1290             


Ser Thr  Val His Glu Arg His  Gly Thr Thr His Gly  Gln Thr Gly 
    1295                 1300                 1305             


Asp Thr  Thr Arg Tyr Ala His  Tyr His Asn Gly Gln  Ser Ala Gln 
    1310                 1315                 1320             


Arg Gly  Ser Arg Thr Thr Gly  Arg Gly Ser Gly His  Ser Glu Tyr 
    1325                 1330                 1335             


Ser Asp  Ser Glu Leu Tyr Ser  Gly Gly Ser His Thr  Tyr Ser Gly 
    1340                 1345                 1350             


His Thr  His Gly Gln Ala Gly  Ser Gln His Gly Glu  Ser Asp Ser 
    1355                 1360                 1365             


Ile Val  His Glu Arg Tyr Gly  Thr Thr His Gly Gln  Thr Gly Asp 
    1370                 1375                 1380             


Thr Thr  Arg His Ala His Tyr  Ser His Gly Gln Ser  Lys Gln Arg 
    1385                 1390                 1395             


Gly Ser  Arg Thr Thr Gly Arg  Arg Gly Ser Gly His  Ser Glu Tyr 
    1400                 1405                 1410             


Ser Asp  Ser Glu Gly His Ser  Gly Gly Ser His Thr  His Ser Gly 
    1415                 1420                 1425             


His Thr  His Gly His Thr His  Gly Gln Ala Gly Ser  Gln His Gly 
    1430                 1435                 1440             


Glu Ser  Gly Ser Ser Gly His  Gly Gly Gln Gly Thr  Thr His Gly 
    1445                 1450                 1455             


Gln Thr  Gly Asp Thr Thr Arg  His Ala His Tyr Gly  His Gly Gln 
    1460                 1465                 1470             


Ser Thr  Gln Arg Gly Ser Arg  Thr Ala Gly Arg Arg  Gly Ser Gly 
    1475                 1480                 1485             


His Ser  Glu Tyr Ser Asp Ser  Glu Gly His Ser Gly  Val Ser His 
    1490                 1495                 1500             


Thr His  Ser Gly His Thr His  Gly Gln Ala Gly Ser  Gln His Gly 
    1505                 1510                 1515             


Glu Ser  Glu Ser Thr Val His  Glu Arg Gln Gln Thr  Thr His Gly 
    1520                 1525                 1530             


Gln Thr  Gly Asp Thr Thr Arg  His Ala His Tyr Gly  His Gly Gln 
    1535                 1540                 1545             


Ser Thr  Gln Thr Gly Ser Arg  Thr Thr Gly Arg Arg  Gly Ser Gly 
    1550                 1555                 1560             


His Ser  Glu Tyr Ser Asp Ser  Glu Gly His Ser Gly  Val Ser His 
    1565                 1570                 1575             


Thr His  Ser Gly His Thr His  Gly Gln Ala Arg Ser  Gln His Gly 
    1580                 1585                 1590             


Glu Ser  Gly Ser Ala Ile His  Gly Arg Gln Gly Thr  Ile His Gly 
    1595                 1600                 1605             


Gln Thr  Gly Asp Thr Thr Arg  His Gly Gln Ser Gly  His Gly Gln 
    1610                 1615                 1620             


Ser Thr  Gln Thr Gly Ser Arg  Thr Thr Gly Arg Arg  Gly Ser Gly 
    1625                 1630                 1635             


His Ser  Glu Tyr Ser Asp Ser  Glu Gly His Ser Gly  Gly Ser His 
    1640                 1645                 1650             


Thr His  Ser Gly His Thr His  Gly Gln Ala Gly Ser  Gln His Gly 
    1655                 1660                 1665             


Glu Ser  Gly Ser Thr Val His  Gly Arg Gln Gly Thr  Ile His Gly 
    1670                 1675                 1680             


Gln Thr  Gly Asp Thr Thr Arg  His Gly Gln Ser Gly  His Gly Gln 
    1685                 1690                 1695             


Ser Ile  Glu Thr Gly Ser Arg  Thr Thr Gly Arg Arg  Gly Ser Gly 
    1700                 1705                 1710             


His Ser  Glu Tyr Ser Asp Ser  Glu Gly His Ser Gly  Val Ser His 
    1715                 1720                 1725             


Thr His  Ser Gly His Thr His  Gly Gln Ala Gly Ser  Gln His Gly 
    1730                 1735                 1740             


Glu Ser  Glu Ser Thr Val His  Glu Arg Gln Gln Thr  Thr His Gly 
    1745                 1750                 1755             


Gln Thr  Gly Asp Ile Thr Glu  His Gly His Ser Ser  His Gly Gln 
    1760                 1765                 1770             


Thr Thr  Gln Thr Gly Ser Arg  Thr Thr Gly Arg Arg  Gly Ser Gly 
    1775                 1780                 1785             


His Ser  Glu Tyr Ser Asp Ser  Glu Trp His Ser Gly  Gly Ser His 
    1790                 1795                 1800             


Thr His  Ser Gly His Thr His  Gly Gln Ala Gly Phe  Gln His Gly 
    1805                 1810                 1815             


Glu Ser  Gly Ser Ala Val His  Gly Arg Gln Gly Thr  Ile His Gly 
    1820                 1825                 1830             


Gln Thr  Gly Asp Thr Thr Arg  His Gly Gln Ser Gly  His Gly Glu 
    1835                 1840                 1845             


Ser Ile  Gln Thr Gly Ser Arg  Thr Ile Gly Arg Arg  Gly Ser Gly 
    1850                 1855                 1860             


His Ser  Glu Tyr Ser Asp Ser  Glu Gly His Ser Gly  Ile Ser His 
    1865                 1870                 1875             


Thr His  Ser Gly His Thr His  Gly Gln Ala Gly Ser  Gln His Gly 
    1880                 1885                 1890             


Glu Ser  Gly Ser Ser Gly His  Gly Arg Gln Gly Thr  Ala His Gly 
    1895                 1900                 1905             


Gln Thr  Gly Asp Thr Thr Arg  His Ala His Tyr Asp  His Gly Gln 
    1910                 1915                 1920             


Ser Thr  Gln Arg Gly Ser Arg  Thr Ala Gly Arg Arg  Gly Ser Gly 
    1925                 1930                 1935             


His Ser  Glu Tyr Ser Asp Ser  Glu Gly His Ser Gly  Val Ser His 
    1940                 1945                 1950             


Thr His  Ser Gly His Thr His  Gly Gln Ala Gly Ser  Gln His Gly 
    1955                 1960                 1965             


Glu Ser  Gly Ala Ala Val His  Gly Arg Gln Gly Ile  Ile His Gly 
    1970                 1975                 1980             


Gln Thr  Gly Asp Thr Thr Arg  His Gly Gln Ser Gly  Gln Gly Gln 
    1985                 1990                 1995             


Ser Thr  Gln Arg Gly Ser Arg  Thr Thr Gly Arg Arg  Gly Ser Gly 
    2000                 2005                 2010             


His Ser  Glu Tyr Ser Asp Ser  Val Gly His Ser Gly  Val Ser His 
    2015                 2020                 2025             


Thr His  Ser Gly His Thr His  Gly Leu Ala Gly Ser  Gln His Gly 
    2030                 2035                 2040             


Glu Ser  Gly Ser Ser Gly His  Gly Arg Gln Gly Thr  Leu His Gly 
    2045                 2050                 2055             


Gln Thr  Gly Asp Thr Thr Arg  His Ala His Tyr Gly  His Gly Gln 
    2060                 2065                 2070             


Ser Thr  Gln Arg Gly Ser Arg  Thr Ala Gly Arg Arg  Gly Ser Gly 
    2075                 2080                 2085             


His Ser  Glu Tyr Ser Asp Ser  Glu Trp His Ser Gly  Gly Ser His 
    2090                 2095                 2100             


Thr His  Ser Gly His Thr His  Gly Gln Ala Gly Ser  Gln His Gly 
    2105                 2110                 2115             


Glu Ser  Gly Ser Ala Val His  Gly Arg Gln Gly Thr  Ile His Gly 
    2120                 2125                 2130             


Gln Thr  Gly Asp Thr Thr Arg  His Gly Gln Ser Gly  His Gly Gln 
    2135                 2140                 2145             


Ser Thr  Gln Ile Gly Pro His  Ser Ser Ser Ser Tyr  Asn Tyr His 
    2150                 2155                 2160             


Ser Glu  Gly Thr Glu Arg Glu  Arg Gly Gln Ser Gly  Leu Val Trp 
    2165                 2170                 2175             


Arg His  Gly Ser Tyr Gly Ser  Ala Asp Tyr Asp Tyr  Gly Glu Ser 
    2180                 2185                 2190             


Arg Phe  Arg His Ser Gln His  Gly Ser Val Ser Tyr  Asn Ser Asn 
    2195                 2200                 2205             


Pro Val  Val Phe Lys Glu Arg  Ser Asp Ile Arg Lys  Ala Ser Ala 
    2210                 2215                 2220             


Phe Gly  Glu Asp His Pro Arg  Tyr Tyr Ala Arg Tyr  Val Asn Arg 
    2225                 2230                 2235             


Gln Pro  Gly Leu Tyr Arg His  Ser Ser Asp Ile Ser  Lys Gln Leu 
    2240                 2245                 2250             


Gly Phe  Ser Gln Ser Gln Arg  Tyr Tyr Tyr Tyr Glu  
    2255                 2260                 2265 


<210> 25
<211> 12
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Human or Mouse filaggrin sequence

<400> 25
Ser Gly Ser Gln Ala Ser Asp Ser Glu Gly His Ser 
1               5                   10          


<210> 26
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Any amino acid

<400> 26
Gln Ser Gly Glu Xaa Ser Gly Arg Ser Xaa Ser Phe Leu Tyr Gln Val 
1               5                   10                  15      


Ser Xaa His Glu Gln Ser Glu Ser 
            20                  


<210> 27
<211> 345
<212> PRT
<213> Homo sapiens

<400> 27
Gln Ser Gly Glu Ser Ser Gly Arg Ser Arg Ser Phe Leu Tyr Gln Val 
1               5                   10                  15      


Ser Ser His Glu Gln Ser Glu Ser Thr His Gly Gln Thr Ala Pro Ser 
            20                  25                  30          


Thr Gly Gly Arg Gln Gly Ser Arg His Glu Gln Ala Arg Asn Ser Ser 
        35                  40                  45              


Arg His Ser Ala Ser Gln Asp Gly Gln Asp Thr Ile Arg Gly His Pro 
    50                  55                  60                  


Gly Ser Ser Arg Gly Gly Arg Gln Gly Ser Tyr His Glu Gln Ser Val 
65                  70                  75                  80  


Asp Arg Ser Gly His Ser Gly Tyr His His Ser His Thr Thr Pro Gln 
                85                  90                  95      


Gly Arg Ser Asp Ala Ser His Gly Gln Ser Gly Pro Arg Ser Ala Ser 
            100                 105                 110         


Arg Gln Thr Arg Asn Glu Glu Gln Ser Gly Asp Gly Ser Arg His Ser 
        115                 120                 125             


Gly Ser Arg His His Glu Pro Ser Thr Arg Ala Gly Ser Ser Arg His 
    130                 135                 140                 


Ser Gln Val Gly Gln Gly Glu Ser Ala Gly Ser Lys Thr Ser Arg Arg 
145                 150                 155                 160 


Gln Gly Ser Ser Val Ser Gln Asp Arg Asp Ser Glu Gly His Ser Glu 
                165                 170                 175     


Asp Ser Glu Arg Arg Ser Glu Ser Ala Ser Arg Asn His Tyr Gly Ser 
            180                 185                 190         


Ala Arg Glu Gln Ser Arg His Gly Ser Arg Asn Pro Arg Ser His Gln 
        195                 200                 205             


Glu Asp Arg Ala Ser His Gly His Ser Ala Glu Ser Ser Arg Gln Ser 
    210                 215                 220                 


Gly Thr Arg His Ala Glu Thr Ser Ser Gly Gly Gln Ala Ala Ser Ser 
225                 230                 235                 240 


Gln Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg His Gly Ser Arg His 
                245                 250                 255     


Gln Gln Ser Ala Asp Ser Ser Thr Asp Ser Gly Thr Gly Arg Arg Gln 
            260                 265                 270         


Asp Ser Ser Val Val Gly Asp Ser Gly Asn Arg Gly Ser Ser Gly Ser 
        275                 280                 285             


Gln Ala Ser Asp Ser Glu Gly His Ser Glu Glu Ser Asp Thr Gln Ser 
    290                 295                 300                 


Val Ser Ala His Gly Gln Ala Gly Pro His Gln Gln Ser His Gln Glu 
305                 310                 315                 320 


Ser Thr Arg Gly Gln Ser Gly Glu Arg Ser Gly Arg Ser Gly Ser Phe 
                325                 330                 335     


Leu Tyr Gln Val Ser Thr His Glu Gln 
            340                 345 


<210> 28
<211> 345
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Gln Ser Gly Glu Ser Ser Gly Arg Ser Arg Ser Phe Leu Tyr Gln Val 
1               5                   10                  15      


Ser Ser His Glu Gln Ser Glu Ser Thr His Gly Gln Thr Ala Pro Ser 
            20                  25                  30          


Thr Gly Gly Arg Gln Gly Ser Arg His Glu Gln Ala Arg Asn Ser Ser 
        35                  40                  45              


Arg His Ser Ala Ser Gln Asp Gly Gln Asp Thr Ile Arg Gly His Pro 
    50                  55                  60                  


Gly Ser Ser Arg Gly Gly Arg Gln Gly Ser Tyr His Glu Gln Ser Val 
65                  70                  75                  80  


Asp Arg Ser Gly His Ser Gly Tyr His His Ser His Thr Thr Pro Gln 
                85                  90                  95      


Gly Arg Ser Asp Ala Ser His Gly Gln Ser Gly Pro Arg Ser Ala Ser 
            100                 105                 110         


Arg Gln Thr Arg Asn Glu Glu Gln Ser Gly Asp Gly Ser Arg His Ser 
        115                 120                 125             


Gly Ser Arg His His Glu Pro Ser Thr Arg Ala Gly Ser Ser Arg His 
    130                 135                 140                 


Ser Gln Val Gly Gln Gly Glu Ser Ala Gly Ser Lys Thr Ser Arg Arg 
145                 150                 155                 160 


Gln Gly Ser Ser Val Ser Gln Asp Arg Asp Ser Glu Gly His Ser Glu 
                165                 170                 175     


Asp Ser Glu Arg Arg Ser Glu Ser Ala Ser Arg Asn His Tyr Gly Ser 
            180                 185                 190         


Ala Arg Glu Gln Ser Arg His Gly Ser Arg Asn Pro Arg Ser His Gln 
        195                 200                 205             


Glu Asp Arg Ala Ser His Gly His Ser Ala Glu Ser Ser Arg Gln Ser 
    210                 215                 220                 


Gly Thr Arg His Ala Glu Thr Ser Ser Gly Gly Gln Ala Ala Ser Ser 
225                 230                 235                 240 


Gln Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg His Gly Ser Arg His 
                245                 250                 255     


Gln Gln Ser Ala Asp Ser Ser Thr Asp Ser Gly Thr Gly Arg Arg Gln 
            260                 265                 270         


Asp Ser Ser Val Val Gly Asp Ser Gly Asn Arg Gly Ser Ser Gly Ser 
        275                 280                 285             


Gln Ala Ser Asp Ser Glu Gly His Ser Glu Glu Ser Asp Thr Gln Ser 
    290                 295                 300                 


Val Ser Ala His Gly Gln Ala Gly Pro His Gln Gln Ser His Gln Glu 
305                 310                 315                 320 


Ser Thr Arg Gly Gln Ser Gly Glu Arg Ser Gly Arg Ser Gly Ser Phe 
                325                 330                 335     


Leu Tyr Gln Val Ser Thr His Glu Gln 
            340                 345 


<210> 29
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      filaggrin sequence

<400> 29
Gln Ser Gly Glu Ser Ser Gly 
1               5           


<210> 30
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
gaagtgcggt tcaacaccct ccg                                               23


<210> 31
<211> 15
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      operational taxonomic unit sequence

<400> 31
gatacagaga tgcat                                                        15


<210> 32
<211> 15
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      operational taxonomic unit sequence

<400> 32
gatacagtga tgcat                                                        15


<210> 33
<211> 15
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      operational taxonomic unit sequence

<400> 33
gatacagtag atgca                                                        15


<210> 34
<211> 15
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      operational taxonomic unit sequence

<400> 34
taccagattt acata                                                        15


<210> 35
<211> 14
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      operational taxonomic unit sequence

<400> 35
taccagatta cata                                                         14


<210> 36
<211> 14
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      operational taxonomic unit sequence

<400> 36
caggtaggat aata                                                         14


<210> 37
<211> 15
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      operational taxonomic unit sequence

<400> 37
caggtaggat aatta                                                        15


<210> 38
<211> 15
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      operational taxonomic unit sequence

<400> 38
caggtaggat aaata                                                        15


<210> 39
<211> 13
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      operational taxonomic unit sequence

<400> 39
caggtaggaa ata                                                          13


<210> 40
<211> 14
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      operational taxonomic unit sequence

<400> 40
gattacagat taca                                                         14


<210> 41
<211> 15
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      operational taxonomic unit sequence

<400> 41
gattacagat ttaca                                                        15


<210> 42
<211> 15
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      operational taxonomic unit sequence

<400> 42
gattacagaa ttaca                                                        15


<210> 43
<211> 328
<212> PRT
<213> Homo sapiens

<400> 43
Ser Leu Tyr Gln Val Ser Thr His Glu Gln Pro Asp Ser Ala His Gly 
1               5                   10                  15      


Arg Thr Gly Thr Ser Thr Gly Gly Arg Gln Gly Ser His His Glu Gln 
            20                  25                  30          


Ala Arg Asp Ser Ser Arg His Ser Ala Ser Gln Glu Gly Gln Asp Thr 
        35                  40                  45              


Ile Arg Gly His Pro Gly Ser Ser Arg Gly Gly Arg Gln Gly Ser His 
    50                  55                  60                  


His Glu Gln Ser Val Asn Arg Ser Gly His Ser Gly Ser His His Ser 
65                  70                  75                  80  


His Thr Thr Ser Gln Gly Arg Ser Asp Ala Ser His Gly Gln Ser Gly 
                85                  90                  95      


Ser Arg Ser Ala Ser Arg Gln Thr Arg Asn Glu Glu Gln Ser Gly Asp 
            100                 105                 110         


Gly Thr Arg His Ser Gly Ser Arg His His Glu Ala Ser Ser Gln Ala 
        115                 120                 125             


Asp Ser Ser Arg His Ser Gln Val Gly Gln Gly Gln Ser Ser Gly Pro 
    130                 135                 140                 


Arg Thr Ser Arg Asn Gln Gly Ser Ser Val Ser Gln Asp Ser Asp Ser 
145                 150                 155                 160 


Gln Gly His Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg 
                165                 170                 175     


Asn His His Gly Ser Ala Gln Glu Gln Ser Arg Asp Gly Ser Arg His 
            180                 185                 190         


Pro Arg Ser His His Glu Asp Arg Ala Gly His Gly His Ser Ala Asp 
        195                 200                 205             


Ser Ser Arg Lys Ser Gly Thr Arg His Thr Gln Asn Ser Ser Ser Gly 
    210                 215                 220                 


Gln Ala Ala Ser Ser His Glu Gln Ala Arg Ser Ser Ala Gly Glu Arg 
225                 230                 235                 240 


His Gly Ser Arg His Gln Leu Gln Ser Ala Asp Ser Ser Arg His Ser 
                245                 250                 255     


Gly Thr Gly His Gly Gln Ala Ser Ser Ala Val Arg Asp Ser Gly His 
            260                 265                 270         


Arg Gly Ser Ser Gly Ser Gln Ala Thr Asp Ser Glu Gly His Ser Glu 
        275                 280                 285             


Asp Ser Asp Thr Gln Ser Val Ser Gly His Gly Gln Ala Gly His His 
    290                 295                 300                 


Gln Gln Ser His Gln Glu Ser Ala Arg Asp Arg Ser Gly Glu Arg Ser 
305                 310                 315                 320 


Arg Arg Ser Gly Ser Phe Leu Tyr 
                325             


<210> 44
<211> 327
<212> PRT
<213> Homo sapiens

<400> 44
Phe Leu Tyr Gln Val Ser Thr His Lys Gln Ser Glu Ser Ser His Gly 
1               5                   10                  15      


Trp Thr Gly Pro Ser Thr Gly Val Arg Gln Gly Ser His His Glu Gln 
            20                  25                  30          


Ala Arg Asp Asn Ser Arg His Ser Ala Ser Gln Asp Gly Gln Asp Thr 
        35                  40                  45              


Ile Arg Gly His Pro Gly Ser Ser Arg Arg Gly Arg Gln Gly Ser His 
    50                  55                  60                  


His Glu Gln Ser Val Asp Arg Ser Gly His Ser Gly Ser His His Ser 
65                  70                  75                  80  


His Thr Thr Ser Gln Gly Arg Ser Asp Ala Ser Arg Gly Gln Ser Gly 
                85                  90                  95      


Ser Arg Ser Ala Ser Arg Thr Thr Arg Asn Glu Glu Gln Ser Arg Asp 
            100                 105                 110         


Gly Ser Arg His Ser Gly Ser Arg His His Glu Ala Ser Ser His Ala 
        115                 120                 125             


Asp Ile Ser Arg His Ser Gln Ala Gly Gln Gly Gln Ser Glu Gly Ser 
    130                 135                 140                 


Arg Thr Ser Arg Arg Gln Gly Ser Ser Val Ser Gln Asp Ser Asp Ser 
145                 150                 155                 160 


Glu Gly His Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg 
                165                 170                 175     


Asn His Arg Gly Ser Ala Gln Glu Gln Ser Arg His Gly Ser Arg His 
            180                 185                 190         


Pro Arg Ser His His Glu Asp Arg Ala Gly His Gly His Ser Ala Asp 
        195                 200                 205             


Ser Ser Arg Gln Ser Gly Thr Pro His Ala Glu Thr Ser Ser Gly Gly 
    210                 215                 220                 


Gln Ala Ala Ser Ser His Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg 
225                 230                 235                 240 


His Gly Ser Arg His Gln Gln Ser Ala Asp Ser Ser Arg His Ser Gly 
                245                 250                 255     


Ile Pro Arg Arg Gln Ala Ser Ser Ala Val Arg Asp Ser Gly His Trp 
            260                 265                 270         


Gly Ser Ser Gly Ser Gln Ala Ser Asp Ser Glu Gly His Ser Glu Glu 
        275                 280                 285             


Ser Asp Thr Gln Ser Val Ser Gly His Gly Gln Asp Gly Pro His Gln 
    290                 295                 300                 


Gln Ser His Gln Glu Ser Ala Arg Asp Trp Ser Gly Gly Arg Ser Gly 
305                 310                 315                 320 


Arg Ser Gly Ser Phe Ile Tyr 
                325         


<210> 45
<211> 327
<212> PRT
<213> Homo sapiens

<400> 45
Phe Ile Tyr Gln Val Ser Thr His Glu Gln Ser Glu Ser Ala His Gly 
1               5                   10                  15      


Arg Thr Arg Thr Ser Thr Gly Arg Arg Gln Gly Ser His His Glu Gln 
            20                  25                  30          


Ala Arg Asp Ser Ser Arg His Ser Ala Ser Gln Glu Gly Gln Asp Thr 
        35                  40                  45              


Ile Arg Ala His Pro Gly Ser Arg Arg Gly Gly Arg Gln Gly Ser His 
    50                  55                  60                  


His Glu Gln Ser Val Asp Arg Ser Gly His Ser Gly Ser His His Ser 
65                  70                  75                  80  


His Thr Thr Ser Gln Gly Arg Ser Asp Ala Ser His Gly Gln Ser Gly 
                85                  90                  95      


Ser Arg Ser Ala Ser Arg Gln Thr Arg Lys Asp Lys Gln Ser Gly Asp 
            100                 105                 110         


Gly Ser Arg His Ser Gly Ser Arg His His Glu Ala Ala Ser Trp Ala 
        115                 120                 125             


Asp Ser Ser Arg His Ser Gln Val Gly Gln Glu Gln Ser Ser Gly Ser 
    130                 135                 140                 


Arg Thr Ser Arg His Gln Gly Ser Ser Val Ser Gln Asp Ser Asp Ser 
145                 150                 155                 160 


Glu Arg His Ser Asp Asp Ser Glu Arg Leu Ser Gly Ser Ala Ser Arg 
                165                 170                 175     


Asn His His Gly Ser Ser Arg Glu Gln Ser Arg Asp Gly Ser Arg His 
            180                 185                 190         


Pro Gly Phe His Gln Glu Asp Arg Ala Ser His Gly His Ser Ala Asp 
        195                 200                 205             


Ser Ser Arg Gln Ser Gly Thr His His Thr Glu Ser Ser Ser His Gly 
    210                 215                 220                 


Gln Ala Val Ser Ser His Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg 
225                 230                 235                 240 


His Gly Ser Arg His Gln Gln Ser Ala Asp Ser Ser Arg His Ser Gly 
                245                 250                 255     


Ile Gly His Arg Gln Ala Ser Ser Ala Val Arg Asp Ser Gly His Arg 
            260                 265                 270         


Gly Ser Ser Gly Ser Gln Val Thr Asn Ser Glu Gly His Ser Glu Asp 
        275                 280                 285             


Ser Asp Thr Gln Ser Val Ser Ala His Gly Gln Ala Gly Pro His Gln 
    290                 295                 300                 


Gln Ser His Lys Glu Ser Ala Arg Gly Gln Ser Gly Glu Ser Ser Gly 
305                 310                 315                 320 


Arg Ser Arg Ser Phe Leu Tyr 
                325         


<210> 46
<211> 327
<212> PRT
<213> Homo sapiens

<400> 46
Phe Leu Tyr Gln Val Ser Ser His Glu Gln Ser Glu Ser Thr His Gly 
1               5                   10                  15      


Gln Thr Ala Pro Ser Thr Gly Gly Arg Gln Gly Ser Arg His Glu Gln 
            20                  25                  30          


Ala Arg Asn Ser Ser Arg His Ser Ala Ser Gln Asp Gly Gln Asp Thr 
        35                  40                  45              


Ile Arg Gly His Pro Gly Ser Ser Arg Gly Gly Arg Gln Gly Ser Tyr 
    50                  55                  60                  


His Glu Gln Ser Val Asp Arg Ser Gly His Ser Gly Tyr His His Ser 
65                  70                  75                  80  


His Thr Thr Pro Gln Gly Arg Ser Asp Ala Ser His Gly Gln Ser Gly 
                85                  90                  95      


Pro Arg Ser Ala Ser Arg Gln Thr Arg Asn Glu Glu Gln Ser Gly Asp 
            100                 105                 110         


Gly Ser Arg His Ser Gly Ser Arg His His Glu Pro Ser Thr Arg Ala 
        115                 120                 125             


Gly Ser Ser Arg His Ser Gln Val Gly Gln Gly Glu Ser Ala Gly Ser 
    130                 135                 140                 


Lys Thr Ser Arg Arg Gln Gly Ser Ser Val Ser Gln Asp Arg Asp Ser 
145                 150                 155                 160 


Glu Gly His Ser Glu Asp Ser Glu Arg Arg Ser Glu Ser Ala Ser Arg 
                165                 170                 175     


Asn His Tyr Gly Ser Ala Arg Glu Gln Ser Arg His Gly Ser Arg Asn 
            180                 185                 190         


Pro Arg Ser His Gln Glu Asp Arg Ala Ser His Gly His Ser Ala Glu 
        195                 200                 205             


Ser Ser Arg Gln Ser Gly Thr Arg His Ala Glu Thr Ser Ser Gly Gly 
    210                 215                 220                 


Gln Ala Ala Ser Ser Gln Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg 
225                 230                 235                 240 


His Gly Ser Arg His Gln Gln Ser Ala Asp Ser Ser Thr Asp Ser Gly 
                245                 250                 255     


Thr Gly Arg Arg Gln Asp Ser Ser Val Val Gly Asp Ser Gly Asn Arg 
            260                 265                 270         


Gly Ser Ser Gly Ser Gln Ala Ser Asp Ser Glu Gly His Ser Glu Glu 
        275                 280                 285             


Ser Asp Thr Gln Ser Val Ser Ala His Gly Gln Ala Gly Pro His Gln 
    290                 295                 300                 


Gln Ser His Gln Glu Ser Thr Arg Gly Gln Ser Gly Glu Arg Ser Gly 
305                 310                 315                 320 


Arg Ser Gly Ser Phe Leu Tyr 
                325         


<210> 47
<211> 328
<212> PRT
<213> Homo sapiens

<400> 47
Phe Leu Tyr Gln Val Ser Thr His Glu Gln Ser Glu Ser Ala His Gly 
1               5                   10                  15      


Arg Thr Gly Pro Ser Thr Gly Gly Arg Gln Arg Ser Arg His Glu Gln 
            20                  25                  30          


Ala Arg Asp Ser Ser Arg His Ser Ala Ser Gln Glu Gly Gln Asp Thr 
        35                  40                  45              


Ile Arg Gly His Pro Gly Ser Ser Arg Gly Gly Arg Gln Gly Ser His 
    50                  55                  60                  


Tyr Glu Gln Ser Val Asp Ser Ser Gly His Ser Gly Ser His His Ser 
65                  70                  75                  80  


His Thr Thr Ser Gln Glu Arg Ser Asp Val Ser Arg Gly Gln Ser Gly 
                85                  90                  95      


Ser Arg Ser Val Ser Arg Gln Thr Arg Asn Glu Lys Gln Ser Gly Asp 
            100                 105                 110         


Gly Ser Arg His Ser Gly Ser Arg His His Glu Ala Ser Ser Arg Ala 
        115                 120                 125             


Asp Ser Ser Arg His Ser Gln Val Gly Gln Gly Gln Ser Ser Gly Pro 
    130                 135                 140                 


Arg Thr Ser Arg Asn Gln Gly Ser Ser Val Ser Gln Asp Ser Asp Ser 
145                 150                 155                 160 


Gln Gly His Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg 
                165                 170                 175     


Asn His Leu Gly Ser Ala Trp Glu Gln Ser Arg Asp Gly Ser Arg His 
            180                 185                 190         


Pro Gly Ser His His Glu Asp Arg Ala Gly His Gly His Ser Ala Asp 
        195                 200                 205             


Ser Ser Arg Gln Ser Gly Thr Arg His Thr Glu Ser Ser Ser Arg Gly 
    210                 215                 220                 


Gln Ala Ala Ser Ser His Glu Gln Ala Arg Ser Ser Ala Gly Glu Arg 
225                 230                 235                 240 


His Gly Ser His His Gln Leu Gln Ser Ala Asp Ser Ser Arg His Ser 
                245                 250                 255     


Gly Ile Gly His Gly Gln Ala Ser Ser Ala Val Arg Asp Ser Gly His 
            260                 265                 270         


Arg Gly Tyr Ser Gly Ser Gln Ala Ser Asp Ser Glu Gly His Ser Glu 
        275                 280                 285             


Asp Ser Asp Thr Gln Ser Val Ser Ala Gln Gly Lys Ala Gly Pro His 
    290                 295                 300                 


Gln Gln Ser His Lys Glu Ser Ala Arg Gly Gln Ser Gly Glu Ser Ser 
305                 310                 315                 320 


Gly Arg Ser Gly Ser Phe Leu Tyr 
                325             


<210> 48
<211> 327
<212> PRT
<213> Homo sapiens

<400> 48
Phe Leu Tyr Gln Val Ser Thr His Glu Gln Ser Glu Ser Thr His Gly 
1               5                   10                  15      


Gln Ser Ala Pro Ser Thr Gly Gly Arg Gln Gly Ser His Tyr Asp Gln 
            20                  25                  30          


Ala Gln Asp Ser Ser Arg His Ser Ala Ser Gln Glu Gly Gln Asp Thr 
        35                  40                  45              


Ile Arg Gly His Pro Gly Pro Ser Arg Gly Gly Arg Gln Gly Ser His 
    50                  55                  60                  


Gln Glu Gln Ser Val Asp Arg Ser Gly His Ser Gly Ser His His Ser 
65                  70                  75                  80  


His Thr Thr Ser Gln Gly Arg Ser Asp Ala Ser Arg Gly Gln Ser Gly 
                85                  90                  95      


Ser Arg Ser Ala Ser Arg Lys Thr Tyr Asp Lys Glu Gln Ser Gly Asp 
            100                 105                 110         


Gly Ser Arg His Ser Gly Ser His His His Glu Ala Ser Ser Trp Ala 
        115                 120                 125             


Asp Ser Ser Arg His Ser Leu Val Gly Gln Gly Gln Ser Ser Gly Pro 
    130                 135                 140                 


Arg Thr Ser Arg Pro Arg Gly Ser Ser Val Ser Gln Asp Ser Asp Ser 
145                 150                 155                 160 


Glu Gly His Ser Glu Asp Ser Glu Arg Arg Ser Gly Ser Ala Ser Arg 
                165                 170                 175     


Asn His His Gly Ser Ala Gln Glu Gln Ser Arg Asp Gly Ser Arg His 
            180                 185                 190         


Pro Arg Ser His His Glu Asp Arg Ala Gly His Gly His Ser Ala Glu 
        195                 200                 205             


Ser Ser Arg Gln Ser Gly Thr His His Ala Glu Asn Ser Ser Gly Gly 
    210                 215                 220                 


Gln Ala Ala Ser Ser His Glu Gln Ala Arg Ser Ser Ala Gly Glu Arg 
225                 230                 235                 240 


His Gly Ser His His Gln Gln Ser Ala Asp Ser Ser Arg His Ser Gly 
                245                 250                 255     


Ile Gly His Gly Gln Ala Ser Ser Ala Val Arg Asp Ser Gly His Arg 
            260                 265                 270         


Gly Ser Ser Gly Ser Gln Ala Ser Asp Ser Glu Gly His Ser Glu Asp 
        275                 280                 285             


Ser Asp Thr Gln Ser Val Ser Ala His Gly Gln Ala Gly Pro His Gln 
    290                 295                 300                 


Gln Ser His Gln Glu Ser Thr Arg Gly Arg Ser Ala Gly Arg Ser Gly 
305                 310                 315                 320 


Arg Ser Gly Ser Phe Leu Tyr 
                325         


<210> 49
<211> 327
<212> PRT
<213> Homo sapiens

<400> 49
Phe Leu Tyr Gln Val Ser Thr His Glu Gln Ser Glu Ser Ala His Gly 
1               5                   10                  15      


Arg Thr Gly Thr Ser Thr Gly Gly Arg Gln Gly Ser His His Lys Gln 
            20                  25                  30          


Ala Arg Asp Ser Ser Arg His Ser Thr Ser Gln Glu Gly Gln Asp Thr 
        35                  40                  45              


Ile His Gly His Pro Gly Ser Ser Ser Gly Gly Arg Gln Gly Ser His 
    50                  55                  60                  


Tyr Glu Gln Leu Val Asp Arg Ser Gly His Ser Gly Ser His His Ser 
65                  70                  75                  80  


His Thr Thr Ser Gln Gly Arg Ser Asp Ala Ser His Gly His Ser Gly 
                85                  90                  95      


Ser Arg Ser Ala Ser Arg Gln Thr Arg Asn Asp Glu Gln Ser Gly Asp 
            100                 105                 110         


Gly Ser Arg His Ser Gly Ser Arg His His Glu Ala Ser Ser Arg Ala 
        115                 120                 125             


Asp Ser Ser Gly His Ser Gln Val Gly Gln Gly Gln Ser Glu Gly Pro 
    130                 135                 140                 


Arg Thr Ser Arg Asn Trp Gly Ser Ser Phe Ser Gln Asp Ser Asp Ser 
145                 150                 155                 160 


Gln Gly His Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg 
                165                 170                 175     


Asn His His Gly Ser Ala Gln Glu Gln Leu Arg Asp Gly Ser Arg His 
            180                 185                 190         


Pro Arg Ser His Gln Glu Asp Arg Ala Gly His Gly His Ser Ala Asp 
        195                 200                 205             


Ser Ser Arg Gln Ser Gly Thr Arg His Thr Gln Thr Ser Ser Gly Gly 
    210                 215                 220                 


Gln Ala Ala Ser Ser His Glu Gln Ala Arg Ser Ser Ala Gly Glu Arg 
225                 230                 235                 240 


His Gly Ser His His Gln Gln Ser Ala Asp Ser Ser Arg His Ser Gly 
                245                 250                 255     


Ile Gly His Gly Gln Ala Ser Ser Ala Val Arg Asp Ser Gly His Arg 
            260                 265                 270         


Gly Tyr Ser Gly Ser Gln Ala Ser Asp Asn Glu Gly His Ser Glu Asp 
        275                 280                 285             


Ser Asp Thr Gln Ser Val Ser Ala His Gly Gln Ala Gly Ser His Gln 
    290                 295                 300                 


Gln Ser His Gln Glu Ser Ala Arg Gly Arg Ser Gly Glu Thr Ser Gly 
305                 310                 315                 320 


His Ser Gly Ser Phe Leu Tyr 
                325         


<210> 50
<211> 327
<212> PRT
<213> Homo sapiens

<400> 50
Phe Leu Tyr Gln Val Ser Thr His Glu Gln Ser Glu Ser Ser His Gly 
1               5                   10                  15      


Trp Thr Gly Pro Ser Thr Arg Gly Arg Gln Gly Ser Arg His Glu Gln 
            20                  25                  30          


Ala Gln Asp Ser Ser Arg His Ser Ala Ser Gln Asp Gly Gln Asp Thr 
        35                  40                  45              


Ile Arg Gly His Pro Gly Ser Ser Arg Gly Gly Arg Gln Gly Tyr His 
    50                  55                  60                  


His Glu His Ser Val Asp Ser Ser Gly His Ser Gly Ser His His Ser 
65                  70                  75                  80  


His Thr Thr Ser Gln Gly Arg Ser Asp Ala Ser Arg Gly Gln Ser Gly 
                85                  90                  95      


Ser Arg Ser Ala Ser Arg Thr Thr Arg Asn Glu Glu Gln Ser Gly Asp 
            100                 105                 110         


Gly Ser Arg His Ser Gly Ser Arg His His Glu Ala Ser Thr His Ala 
        115                 120                 125             


Asp Ile Ser Arg His Ser Gln Ala Val Gln Gly Gln Ser Glu Gly Ser 
    130                 135                 140                 


Arg Arg Ser Arg Arg Gln Gly Ser Ser Val Ser Gln Asp Ser Asp Ser 
145                 150                 155                 160 


Glu Gly His Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg 
                165                 170                 175     


Asn His His Gly Ser Ala Gln Glu Gln Leu Arg Asp Gly Ser Arg His 
            180                 185                 190         


Pro Arg Ser His Gln Glu Asp Arg Ala Gly His Gly His Ser Ala Asp 
        195                 200                 205             


Ser Ser Arg Gln Ser Gly Thr Arg His Thr Gln Thr Ser Ser Gly Gly 
    210                 215                 220                 


Gln Ala Ala Ser Ser His Glu Gln Ala Arg Ser Ser Ala Gly Glu Arg 
225                 230                 235                 240 


His Gly Ser His His Gln Gln Ser Ala Asp Ser Ser Arg His Ser Gly 
                245                 250                 255     


Ile Gly His Gly Gln Ala Ser Ser Ala Val Arg Asp Ser Gly His Arg 
            260                 265                 270         


Gly Tyr Ser Gly Ser Gln Ala Ser Asp Asn Glu Gly His Ser Glu Asp 
        275                 280                 285             


Ser Asp Thr Gln Ser Val Ser Ala His Gly Gln Ala Gly Ser His Gln 
    290                 295                 300                 


Gln Ser His Gln Glu Ser Ala Arg Gly Arg Ser Gly Glu Thr Ser Gly 
305                 310                 315                 320 


His Ser Gly Ser Phe Leu Tyr 
                325         


<210> 51
<211> 327
<212> PRT
<213> Homo sapiens

<400> 51
Phe Leu Tyr Gln Val Ser Thr His Glu Gln Ser Glu Ser Ser His Gly 
1               5                   10                  15      


Trp Thr Gly Pro Ser Thr Arg Gly Arg Gln Gly Ser Arg His Glu Gln 
            20                  25                  30          


Ala Gln Asp Ser Ser Arg His Ser Ala Ser Gln Tyr Gly Gln Asp Thr 
        35                  40                  45              


Ile Arg Gly His Pro Gly Ser Ser Arg Gly Gly Arg Gln Gly Tyr His 
    50                  55                  60                  


His Glu His Ser Val Asp Ser Ser Gly His Ser Gly Ser His His Ser 
65                  70                  75                  80  


His Thr Thr Ser Gln Gly Arg Ser Asp Ala Ser Arg Gly Gln Ser Gly 
                85                  90                  95      


Ser Arg Ser Ala Ser Arg Thr Thr Arg Asn Glu Glu Gln Ser Gly Asp 
            100                 105                 110         


Ser Ser Arg His Ser Val Ser Arg His His Glu Ala Ser Thr His Ala 
        115                 120                 125             


Asp Ile Ser Arg His Ser Gln Ala Val Gln Gly Gln Ser Glu Gly Ser 
    130                 135                 140                 


Arg Arg Ser Arg Arg Gln Gly Ser Ser Val Ser Gln Asp Ser Asp Ser 
145                 150                 155                 160 


Glu Gly His Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg 
                165                 170                 175     


Asn His Arg Gly Ser Val Gln Glu Gln Ser Arg His Gly Ser Arg His 
            180                 185                 190         


Pro Arg Ser His His Glu Asp Arg Ala Gly His Gly His Ser Ala Asp 
        195                 200                 205             


Arg Ser Arg Gln Ser Gly Thr Arg His Ala Glu Thr Ser Ser Gly Gly 
    210                 215                 220                 


Gln Ala Ala Ser Ser His Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg 
225                 230                 235                 240 


His Gly Ser Arg His Gln Gln Ser Ala Asp Ser Ser Arg His Ser Gly 
                245                 250                 255     


Ile Pro Arg Gly Gln Ala Ser Ser Ala Val Arg Asp Ser Arg His Trp 
            260                 265                 270         


Gly Ser Ser Gly Ser Gln Ala Ser Asp Ser Glu Gly His Ser Glu Glu 
        275                 280                 285             


Ser Asp Thr Gln Ser Val Ser Gly His Gly Gln Ala Gly Pro His Gln 
    290                 295                 300                 


Gln Ser His Gln Glu Ser Ala Arg Asp Arg Ser Gly Gly Arg Ser Gly 
305                 310                 315                 320 


Arg Ser Gly Ser Phe Leu Tyr 
                325         


<210> 52
<211> 327
<212> PRT
<213> Homo sapiens

<400> 52
Phe Leu Tyr Gln Val Ser Thr His Glu Gln Ser Glu Ser Ala His Gly 
1               5                   10                  15      


Arg Thr Arg Thr Ser Thr Gly Arg Arg Gln Gly Ser His His Glu Gln 
            20                  25                  30          


Ala Arg Asp Ser Ser Arg His Ser Ala Ser Gln Glu Gly Gln Asp Thr 
        35                  40                  45              


Ile Arg Gly His Pro Gly Ser Ser Arg Arg Gly Arg Gln Gly Ser His 
    50                  55                  60                  


Tyr Glu Gln Ser Val Asp Arg Ser Gly His Ser Gly Ser His His Ser 
65                  70                  75                  80  


His Thr Thr Ser Gln Gly Arg Ser Asp Ala Ser Arg Gly Gln Ser Gly 
                85                  90                  95      


Ser Arg Ser Ala Ser Arg Gln Thr Arg Asn Asp Glu Gln Ser Gly Asp 
            100                 105                 110         


Gly Ser Arg His Ser Trp Ser His His His Glu Ala Ser Thr Gln Ala 
        115                 120                 125             


Asp Ser Ser Arg His Ser Gln Ser Gly Gln Gly Gln Ser Ala Gly Pro 
    130                 135                 140                 


Arg Thr Ser Arg Asn Gln Gly Ser Ser Val Ser Gln Asp Ser Asp Ser 
145                 150                 155                 160 


Gln Gly His Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg 
                165                 170                 175     


Asn His Arg Gly Ser Ala Gln Glu Gln Ser Arg Asp Gly Ser Arg His 
            180                 185                 190         


Pro Thr Ser His His Glu Asp Arg Ala Gly His Gly His Ser Ala Glu 
        195                 200                 205             


Ser Ser Arg Gln Ser Gly Thr His His Ala Glu Asn Ser Ser Gly Gly 
    210                 215                 220                 


Gln Ala Ala Ser Ser His Glu Gln Ala Arg Ser Ser Ala Gly Glu Arg 
225                 230                 235                 240 


His Gly Ser His His Gln Gln Ser Ala Asp Ser Ser Arg His Ser Gly 
                245                 250                 255     


Ile Gly His Gly Gln Ala Ser Ser Ala Val Arg Asp Ser Gly His Arg 
            260                 265                 270         


Gly Ser Ser Gly Ser Gln Ala Ser Asp Ser Glu Gly His Ser Glu Asp 
        275                 280                 285             


Ser Asp Thr Gln Ser Val Ser Ala His Gly Gln Ala Gly Pro His Gln 
    290                 295                 300                 


Gln Ser His Gln Glu Ser Thr Arg Gly Arg Ser Ala Gly Arg Ser Gly 
305                 310                 315                 320 


Arg Ser Gly Ser Phe Leu Tyr 
                325         


