                         SEQUENCE LISTING

<110>  CARMEL-HAIFA UNIVERSITY ECONOMIC CORP
 
<120>  METHODS FOR TREATING DEPRESSION AND MAJOR DEPRESIVE DISORDER

<130>  CRML-P-021-PCT

<150>  62/556440
<151>  2017-09-10

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1

Lys Arg Pro Pro Lys Leu Gly Gln Ile Gly Arg Ser Lys Arg Val Val 
1               5                   10                  15      


Ile Glu Asp Asp Arg 
            20      


<210>  2
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Thr Ile Thr Cys Thr Arg Phe Thr Glu Glu Tyr Gln Leu Phe 
1               5                   10                  15      


Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val Lys 
            20                  25                  30          


Val Leu Ala Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys Lys 
        35                  40                  45              


Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile Cys 
    50                  55                  60                  


Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile Ser 
65                  70                  75                  80  


Glu Glu Gly His His Tyr Leu Ile Phe Asp Leu Val Thr Gly Gly Glu 
                85                  90                  95      


Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp Ala 
            100                 105                 110         


Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His Gln 
        115                 120                 125             


Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu Ala 
    130                 135                 140                 


Ser Lys Leu Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu Ala 
145                 150                 155                 160 


Ile Glu Val Glu Gly Glu Gln Gln Ala Trp Phe Gly Phe Ala Gly Thr 
                165                 170                 175     


Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly Lys 
            180                 185                 190         


Pro Val Asp Leu Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu Val 
        195                 200                 205             


Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln Gln 
    210                 215                 220                 


Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr Val 
225                 230                 235                 240 


Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn Pro 
                245                 250                 255     


Ser Lys Arg Ile Thr Ala Ala Glu Ala Leu Lys His Pro Trp Ile Ser 
            260                 265                 270         


His Arg Ser Thr Val Ala Ser Cys Met His Arg Gln Glu Thr Val Asp 
        275                 280                 285             


Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile Leu 
    290                 295                 300                 


Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Gly Gly Lys Ser Gly Gly 
305                 310                 315                 320 


Asn Lys Lys Ser Asp Gly Val Lys Glu Ser Ser Glu Ser Thr Asn Thr 
                325                 330                 335     


Thr Ile Glu Asp Glu Asp Thr Lys Val Arg Lys Gln Glu Ile Ile Lys 
            340                 345                 350         


Val Thr Glu Gln Leu Ile Glu Ala Ile Ser Asn Gly Asp Phe Glu Ser 
        355                 360                 365             


Tyr Thr Lys Met Cys Asp Pro Gly Met Thr Ala Phe Glu Pro Glu Ala 
    370                 375                 380                 


Leu Gly Asn Leu Val Glu Gly Leu Asp Phe His Arg Phe Tyr Phe Glu 
385                 390                 395                 400 


Asn Leu Trp Ser Arg Asn Ser Lys Pro Val His Thr Thr Ile Leu Asn 
                405                 410                 415     


Pro His Ile His Leu Met Gly Asp Glu Ser Ala Cys Ile Ala Tyr Ile 
            420                 425                 430         


Arg Ile Thr Gln Tyr Leu Asp Ala Gly Gly Ile Pro Arg Thr Ala Gln 
        435                 440                 445             


Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Ile 
    450                 455                 460                 


Val His Phe His Arg Ser Gly Ala Pro Ser Val Leu Pro His 
465                 470                 475             


<210>  3
<211>  542
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Thr Thr Val Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Thr Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala His Glu Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Val Gly Arg Gln Thr 
305                 310                 315                 320 


Thr Ala Pro Ala Thr Met Ser Thr Ala Ala Ser Gly Thr Thr Met Gly 
                325                 330                 335     


Leu Val Glu Gln Ala Lys Ser Leu Leu Asn Lys Lys Ala Asp Gly Val 
            340                 345                 350         


Lys Pro Gln Thr Asn Ser Thr Lys Asn Ser Ala Ala Ala Thr Ser Pro 
        355                 360                 365             


Lys Gly Thr Leu Pro Pro Ala Ala Leu Glu Pro Gln Thr Thr Val Ile 
    370                 375                 380                 


His Asn Pro Val Asp Gly Ile Lys Glu Ser Ser Asp Ser Ala Asn Thr 
385                 390                 395                 400 


Thr Ile Glu Asp Glu Asp Ala Lys Ala Arg Lys Gln Glu Ile Ile Lys 
                405                 410                 415     


Thr Thr Glu Gln Leu Ile Glu Ala Val Asn Asn Gly Asp Phe Glu Ala 
            420                 425                 430         


Tyr Ala Lys Ile Cys Asp Pro Gly Leu Thr Ser Phe Glu Pro Glu Ala 
        435                 440                 445             


Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu 
    450                 455                 460                 


Asn Leu Leu Ala Lys Asn Ser Lys Pro Ile His Thr Thr Ile Leu Asn 
465                 470                 475                 480 


Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr Ile 
                485                 490                 495     


Arg Leu Thr Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Thr Ser Gln 
            500                 505                 510         


Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn 
        515                 520                 525             


Val His Phe His Cys Ser Gly Ala Pro Val Ala Pro Leu Gln 
    530                 535                 540         


<210>  4
<211>  12
<212>  PRT
<213>  Human immunodeficiency virus

<400>  4

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
1               5                   10          


