                         SEQUENCE LISTING

<110>  UNIVERSITY OF OSLO
 
<120>  VACCINE MOLECULES

<130>  INVEN-35344/WO-1/ORD

<150>  US 62/555,300
<151>  2017-09-07

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  1
ggcctcggtg gcctggacca gatttg                                            26


<210>  2
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  2
accggccctg caggcctcac tggtaggtgc ccatactctc                             40


<210>  3
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  3
ggcctcggtg gcctggacaa gatttg                                            26


<210>  4
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  4
accggccctg caggcctcac agggaggag                                         29


<210>  5
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  5
ggcctcggtg gcctggacag gatttg                                            26


<210>  6
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  6
accggccctg caggcctcac agggaggc                                          28


<210>  7
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  7
ggcctcggtg gcctggatga gatttg                                            26


<210>  8
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  8
accggccctg caggcctcac agggaggag                                         29


<210>  9
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  9
ggcctcggtg gcctggacag gatttg                                            26


<210>  10
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  10
accggccctg caggcctcaa atgctggag                                         29


<210>  11
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  11
ggcctcggtg gcctggacaa gatttg                                            26


<210>  12
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  12
cagggaggac actgtgctgt agatggtcag aatcttgtag gtg                         43


<210>  13
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  13
accggccctg caggcctcac agggaggac                                         29


<210>  14
<211>  918
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  14

Val Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 
1               5                   10                  15      


Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly 
            20                  25                  30          


Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Leu Thr Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro 
65                  70                  75                  80  


Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
                85                  90                  95      


Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
        115                 120                 125             


Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala Ser Val Thr 
    130                 135                 140                 


Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser Trp Met Ser 
145                 150                 155                 160 


Trp Leu Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile Gly Trp Ile 
                165                 170                 175     


Phe Pro Arg Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly Lys 
            180                 185                 190         


Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu 
        195                 200                 205             


Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Arg 
    210                 215                 220                 


Gly Asp Tyr His Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
225                 230                 235                 240 


Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
                245                 250                 255     


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Gly 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln 
        275                 280                 285             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    290                 295                 300                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
305                 310                 315                 320 


Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro 
                325                 330                 335     


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            340                 345                 350         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser Val 
        355                 360                 365             


Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu 
    370                 375                 380                 


Ser Pro Gly Lys Gly Leu Gly Gly Leu Arg Asp Thr Leu Cys Ile Gly 
385                 390                 395                 400 


Tyr His Ala Asn Asn Ser Thr Asp Thr Val Asp Thr Val Leu Glu Lys 
                405                 410                 415     


Asn Val Thr Val Thr His Ser Val Asn Leu Leu Glu Asp Lys His Asn 
            420                 425                 430         


Gly Lys Leu Cys Lys Leu Arg Gly Val Ala Pro Leu His Leu Gly Lys 
        435                 440                 445             


Cys Asn Ile Ala Gly Trp Ile Leu Gly Asn Pro Glu Cys Glu Ser Leu 
    450                 455                 460                 


Ser Thr Ala Ser Ser Trp Ser Tyr Ile Val Glu Thr Ser Ser Ser Asp 
465                 470                 475                 480 


Asn Gly Thr Cys Tyr Pro Gly Asp Phe Ile Asp Tyr Glu Glu Leu Arg 
                485                 490                 495     


Glu Gln Leu Ser Ser Val Ser Ser Phe Glu Arg Phe Glu Ile Phe Pro 
            500                 505                 510         


Lys Thr Ser Ser Trp Pro Asn His Asp Ser Asn Lys Gly Val Thr Ala 
        515                 520                 525             


Ala Cys Pro His Ala Gly Ala Lys Ser Phe Tyr Lys Asn Leu Ile Trp 
    530                 535                 540                 


Leu Val Lys Lys Gly Asn Ser Tyr Pro Lys Leu Ser Lys Ser Tyr Ile 
545                 550                 555                 560 


Asn Asp Lys Gly Lys Glu Val Leu Val Leu Trp Gly Ile His His Pro 
                565                 570                 575     


Ser Thr Ser Ala Asp Gln Gln Ser Leu Tyr Gln Asn Ala Asp Ala Tyr 
            580                 585                 590         


Val Phe Val Gly Ser Ser Arg Tyr Ser Lys Lys Phe Lys Pro Glu Ile 
        595                 600                 605             


Ala Ile Arg Pro Lys Val Arg Asp Gln Glu Gly Arg Met Asn Tyr Tyr 
    610                 615                 620                 


Trp Thr Leu Val Glu Pro Gly Asp Lys Ile Thr Phe Glu Ala Thr Gly 
625                 630                 635                 640 


Asn Leu Val Val Pro Arg Tyr Ala Phe Ala Met Glu Arg Asn Ala Gly 
                645                 650                 655     


Ser Gly Ile Ile Ile Ser Asp Thr Pro Val His Asp Cys Asn Thr Thr 
            660                 665                 670         


Cys Gln Thr Pro Lys Gly Ala Ile Asn Thr Ser Leu Pro Phe Gln Asn 
        675                 680                 685             


Ile His Pro Ile Thr Ile Gly Lys Cys Pro Lys Tyr Val Lys Ser Thr 
    690                 695                 700                 


Lys Leu Arg Leu Ala Thr Gly Leu Arg Asn Val Pro Ser Ile Gln Ser 
705                 710                 715                 720 


Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Thr 
                725                 730                 735     


Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly 
            740                 745                 750         


Ser Gly Tyr Ala Ala Asp Leu Lys Ser Thr Gln Asn Ala Ile Asp Glu 
        755                 760                 765             


Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr Gln Phe 
    770                 775                 780                 


Thr Ala Val Gly Lys Glu Phe Asn His Leu Glu Lys Arg Ile Glu Asn 
785                 790                 795                 800 


Leu Asn Lys Lys Val Asp Asp Gly Phe Leu Asp Ile Trp Thr Tyr Asn 
                805                 810                 815     


Ala Glu Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Tyr His 
            820                 825                 830         


Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys Val Arg Ser Gln Leu Lys 
        835                 840                 845             


Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys 
    850                 855                 860                 


Cys Asp Asn Thr Cys Met Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr 
865                 870                 875                 880 


Pro Lys Tyr Ser Glu Glu Ala Lys Leu Asn Arg Glu Glu Ile Asp Gly 
                885                 890                 895     


Val Lys Leu Glu Ser Thr Arg Ile Tyr Gln Ile Leu Ala Ile Tyr Ser 
            900                 905                 910         


Thr Val Ala Ser Ser Leu 
        915             


<210>  15
<211>  523
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  15

Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr Val 
1               5                   10                  15      


Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn Leu 
            20                  25                  30          


Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile Ala 
        35                  40                  45              


Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly Asn 
    50                  55                  60                  


Pro Glu Cys Asp Pro Leu Leu Pro Val Arg Ser Trp Ser Tyr Ile Val 
65                  70                  75                  80  


Glu Thr Pro Asn Ser Glu Asn Gly Ile Cys Tyr Pro Gly Asp Phe Ile 
                85                  90                  95      


Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe Glu 
            100                 105                 110         


Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Asn Thr 
        115                 120                 125             


Asn Gly Val Thr Ala Ala Cys Ser His Glu Gly Lys Ser Ser Phe Tyr 
    130                 135                 140                 


Arg Asn Leu Leu Trp Leu Thr Glu Lys Glu Gly Ser Tyr Pro Lys Leu 
145                 150                 155                 160 


Lys Asn Ser Tyr Val Asn Lys Lys Gly Lys Glu Val Leu Val Leu Trp 
                165                 170                 175     


Gly Ile His His Pro Pro Asn Ser Lys Glu Gln Gln Asn Leu Tyr Gln 
            180                 185                 190         


Asn Glu Asn Ala Tyr Val Ser Val Val Thr Ser Asn Tyr Asn Arg Arg 
        195                 200                 205             


Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Arg Asp Gln Ala Gly 
    210                 215                 220                 


Arg Met Asn Tyr Tyr Trp Thr Leu Leu Lys Pro Gly Asp Thr Ile Ile 
225                 230                 235                 240 


Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Met Tyr Ala Phe Ala Leu 
                245                 250                 255     


Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser Met His 
            260                 265                 270         


Glu Cys Asn Thr Lys Cys Gln Thr Pro Leu Gly Ala Ile Asn Ser Ser 
        275                 280                 285             


Leu Pro Tyr Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys Pro Lys 
    290                 295                 300                 


Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn Ile 
305                 310                 315                 320 


Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
                325                 330                 335     


Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr His His 
            340                 345                 350         


Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr Gln 
        355                 360                 365             


Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Thr Val Ile Glu Lys 
    370                 375                 380                 


Met Asn Ile Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu Glu 
385                 390                 395                 400 


Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu Asp 
                405                 410                 415     


Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu Arg 
            420                 425                 430         


Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys Val 
        435                 440                 445             


Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe 
    450                 455                 460                 


Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg Asn 
465                 470                 475                 480 


Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn Arg 
                485                 490                 495     


Glu Lys Val Asp Gly Val Lys Leu Glu Ser Met Gly Ile Tyr Gln Ile 
            500                 505                 510         


Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu 
        515                 520             


<210>  16
<211>  524
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  16

Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr Val 
1               5                   10                  15      


Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn Leu 
            20                  25                  30          


Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val Ala 
        35                  40                  45              


Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly Asn 
    50                  55                  60                  


Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile Val 
65                  70                  75                  80  


Glu Thr Pro Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe Ile 
                85                  90                  95      


Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe Glu 
            100                 105                 110         


Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp Ser 
        115                 120                 125             


Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser Phe 
    130                 135                 140                 


Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro Lys 
145                 150                 155                 160 


Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val Leu 
                165                 170                 175     


Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu Tyr 
            180                 185                 190         


Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Ser Ser Arg Tyr Ser Lys 
        195                 200                 205             


Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Gln Glu 
    210                 215                 220                 


Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys Ile 
225                 230                 235                 240 


Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe Ala 
                245                 250                 255     


Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro Val 
            260                 265                 270         


His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn Thr 
        275                 280                 285             


Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys Pro 
    290                 295                 300                 


Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg Asn 
305                 310                 315                 320 


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
                325                 330                 335     


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
            340                 345                 350         


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser Thr 
        355                 360                 365             


Gln Asn Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
    370                 375                 380                 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His Leu 
385                 390                 395                 400 


Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
                405                 410                 415     


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
            420                 425                 430         


Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
        435                 440                 445             


Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
    450                 455                 460                 


Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val Lys 
465                 470                 475                 480 


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu Asn 
                485                 490                 495     


Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Thr Arg Ile Tyr Gln 
            500                 505                 510         


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu 
        515                 520                 


<210>  17
<211>  511
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  17

Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
1               5                   10                  15      


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
            20                  25                  30          


Leu Glu Arg Thr His Asn Gly Lys Leu Cys Asp Leu Asn Gly Val Lys 
        35                  40                  45              


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
    50                  55                  60                  


Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val 
65                  70                  75                  80  


Glu Lys Ala Ser Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asn Phe Asn 
                85                  90                  95      


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Ser His Phe Glu 
            100                 105                 110         


Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Asn His Asp Ala Ser 
        115                 120                 125             


Ser Gly Val Ser Ser Ala Cys Pro Tyr Leu Gly Lys Ser Ser Phe Phe 
    130                 135                 140                 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Ser Thr Tyr Pro Thr Ile 
145                 150                 155                 160 


Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
                165                 170                 175     


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr Gln 
            180                 185                 190         


Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
        195                 200                 205             


Leu Val Pro Glu Ile Ala Thr Arg Pro Lys Val Asn Gly Gln Ser Gly 
    210                 215                 220                 


Arg Ile Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
225                 230                 235                 240 


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
                245                 250                 255     


Val Lys Lys Gly Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr Gly 
            260                 265                 270         


Asn Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser 
        275                 280                 285             


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
    290                 295                 300                 


Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ala 
305                 310                 315                 320 


Pro Gln Arg Glu Lys Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
                325                 330                 335     


Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His 
            340                 345                 350         


Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Glu Ser Thr Gln 
        355                 360                 365             


Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser Ile Ile Asn Lys 
    370                 375                 380                 


Met Asn Thr Gln Phe Glu Ala Val Gly Lys Glu Phe Asn Asn Leu Glu 
385                 390                 395                 400 


Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp 
                405                 410                 415     


Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg 
            420                 425                 430         


Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val 
        435                 440                 445             


Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe 
    450                 455                 460                 


Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Lys Asn 
465                 470                 475                 480 


Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala Arg Leu Asn Arg 
                485                 490                 495     


Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Met Gly Thr Tyr Gln 
            500                 505                 510     


<210>  18
<211>  525
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  18

Asp Lys Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Thr Gln Val 
1               5                   10                  15      


Asp Thr Ile Leu Glu Lys Asn Val Thr Val Thr His Ser Val Glu Leu 
            20                  25                  30          


Leu Glu Asn Gln Lys Glu Glu Arg Phe Cys Lys Ile Leu Asn Lys Ala 
        35                  40                  45              


Pro Leu Asp Leu Arg Gly Cys Thr Ile Glu Gly Trp Ile Leu Gly Asn 
    50                  55                  60                  


Pro Gln Cys Asp Leu Leu Leu Gly Asp Gln Ser Trp Ser Tyr Ile Val 
65                  70                  75                  80  


Glu Arg Pro Thr Ala Gln Asn Gly Ile Cys Tyr Pro Gly Ala Leu Asn 
                85                  90                  95      


Glu Val Glu Glu Leu Lys Ala Leu Ile Gly Ser Gly Glu Arg Val Glu 
            100                 105                 110         


Arg Phe Glu Met Phe Pro Lys Ser Thr Trp Thr Gly Val Asp Thr Ser 
        115                 120                 125             


Ser Gly Val Thr Lys Ala Cys Pro Tyr Asn Ser Gly Ser Ser Phe Tyr 
    130                 135                 140                 


Arg Asn Leu Leu Trp Ile Ile Lys Thr Lys Ser Ala Ala Tyr Pro Val 
145                 150                 155                 160 


Ile Lys Gly Thr Tyr Asn Asn Thr Gly Ser Gln Pro Ile Leu Tyr Phe 
                165                 170                 175     


Trp Gly Val His His Pro Pro Asp Thr Asn Glu Gln Asn Thr Leu Tyr 
            180                 185                 190         


Gly Ser Gly Asp Arg Tyr Val Arg Met Gly Thr Glu Ser Met Asn Phe 
        195                 200                 205             


Ala Lys Ser Pro Glu Ile Ala Ala Arg Pro Ala Val Asn Gly Gln Arg 
    210                 215                 220                 


Gly Arg Ile Asp Tyr Tyr Trp Ser Val Leu Lys Pro Gly Glu Thr Leu 
225                 230                 235                 240 


Asn Val Glu Ser Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Tyr Lys 
                245                 250                 255     


Phe Val Ser Thr Asn Asn Lys Gly Ala Ile Phe Lys Ser Asn Leu Pro 
            260                 265                 270         


Ile Glu Asn Cys Asp Ala Thr Cys Gln Thr Ile Ala Gly Val Leu Arg 
        275                 280                 285             


Thr Asn Lys Thr Phe Gln Asn Val Ser Pro Leu Trp Ile Gly Glu Cys 
    290                 295                 300                 


Pro Lys Tyr Val Lys Ser Glu Ser Leu Arg Leu Ala Thr Gly Leu Arg 
305                 310                 315                 320 


Asn Val Pro Gln Ile Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly 
                325                 330                 335     


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
            340                 345                 350         


His His Glu Asn Ser Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser 
        355                 360                 365             


Thr Gln Lys Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Ile Ile 
    370                 375                 380                 


Asp Lys Met Asn Thr Gln Phe Glu Ala Val Asp His Glu Phe Ser Asn 
385                 390                 395                 400 


Leu Glu Arg Arg Ile Asp Asn Leu Asn Lys Arg Met Glu Asp Gly Phe 
                405                 410                 415     


Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
            420                 425                 430         


Glu Arg Thr Leu Asp Leu His Asp Ala Asn Val Lys Asn Leu Tyr Glu 
        435                 440                 445             


Lys Val Lys Ser Gln Leu Arg Asp Asn Ala Asn Asp Leu Gly Asn Gly 
    450                 455                 460                 


Cys Phe Glu Phe Trp His Lys Cys Asp Asn Glu Cys Ile Glu Ser Val 
465                 470                 475                 480 


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Gln Asp Glu Ser Lys Leu 
                485                 490                 495     


Asn Arg Gln Glu Ile Glu Ser Val Lys Leu Asp Asn Leu Gly Val Tyr 
            500                 505                 510         


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ser Ser Ser Leu 
        515                 520                 525 


<210>  19
<211>  524
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  19

Asp Arg Ile Cys Ile Gly Tyr Gln Ser Asn Asn Ser Thr Asp Thr Val 
1               5                   10                  15      


Asn Thr Leu Ile Glu Gln Asn Val Pro Val Thr Gln Thr Met Glu Leu 
            20                  25                  30          


Val Glu Thr Glu Lys His Pro Ala Tyr Cys Asn Thr Asp Leu Gly Ala 
        35                  40                  45              


Pro Leu Glu Leu Arg Asp Cys Lys Ile Glu Ala Val Ile Tyr Gly Asn 
    50                  55                  60                  


Pro Lys Cys Asp Ile His Leu Lys Asp Gln Gly Trp Ser Tyr Ile Val 
65                  70                  75                  80  


Glu Arg Pro Ser Ala Pro Glu Gly Met Cys Tyr Pro Gly Ser Ile Glu 
                85                  90                  95      


Asn Leu Glu Glu Leu Arg Phe Val Phe Ser Ser Ala Ala Ser Tyr Lys 
            100                 105                 110         


Arg Ile Arg Leu Phe Asp Tyr Ser Arg Trp Asn Val Thr Arg Ser Gly 
        115                 120                 125             


Thr Ser Lys Ala Cys Asn Ala Ser Thr Gly Gly Gln Ser Phe Tyr Arg 
    130                 135                 140                 


Ser Ile Asn Trp Leu Thr Lys Lys Lys Pro Asp Thr Tyr Asp Phe Asn 
145                 150                 155                 160 


Glu Gly Thr Tyr Val Asn Asn Glu Asp Gly Asp Ile Ile Phe Leu Trp 
                165                 170                 175     


Gly Ile His His Pro Pro Asp Thr Lys Glu Gln Thr Thr Leu Tyr Lys 
            180                 185                 190         


Asn Ala Asn Thr Leu Thr Ser Val Thr Thr Asn Thr Ile Asn Arg Asn 
        195                 200                 205             


Phe Gln Pro Asn Ile Gly Pro Arg Pro Leu Val Arg Gly Gln Gln Gly 
    210                 215                 220                 


Arg Met Asp Tyr Tyr Trp Gly Ile Leu Lys Arg Gly Glu Thr Leu Lys 
225                 230                 235                 240 


Ile Arg Thr Asn Gly Asn Leu Ile Ala Pro Glu Phe Gly Tyr Leu Leu 
                245                 250                 255     


Lys Gly Glu Ser His Gly Arg Ile Ile Gln Asn Glu Asp Ile Pro Ile 
            260                 265                 270         


Gly Asn Cys Asn Thr Lys Cys Gln Thr Tyr Ala Gly Ala Ile Asn Ser 
        275                 280                 285             


Ser Lys Pro Phe Gln Asn Ala Ser Arg His Tyr Met Gly Glu Cys Pro 
    290                 295                 300                 


Lys Tyr Val Lys Lys Ala Ser Leu Arg Leu Ala Val Gly Leu Arg Asn 
305                 310                 315                 320 


Thr Pro Ser Val Glu Pro Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
                325                 330                 335     


Ile Glu Gly Gly Trp Ser Gly Met Ile Asp Gly Trp Tyr Gly Phe His 
            340                 345                 350         


His Ser Asn Ser Glu Gly Thr Gly Met Ala Ala Asp Gln Lys Ser Thr 
        355                 360                 365             


Gln Glu Ala Ile Asp Lys Ile Thr Asn Lys Val Asn Asn Ile Val Asp 
    370                 375                 380                 


Lys Met Asn Arg Glu Phe Glu Val Val Asn His Glu Phe Ser Glu Val 
385                 390                 395                 400 


Glu Lys Arg Ile Asn Met Ile Asn Asp Lys Ile Asp Asp Gln Ile Glu 
                405                 410                 415     


Asp Leu Trp Ala Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Gln 
            420                 425                 430         


Lys Thr Leu Asp Glu His Asp Ser Asn Val Lys Asn Leu Phe Asp Glu 
        435                 440                 445             


Val Lys Arg Arg Leu Ser Ala Asn Ala Ile Asp Ala Gly Asn Gly Cys 
    450                 455                 460                 


Phe Asp Ile Leu His Lys Cys Asp Asn Glu Cys Met Glu Thr Ile Lys 
465                 470                 475                 480 


Asn Gly Thr Tyr Asn His Lys Glu Tyr Glu Glu Glu Ala Lys Leu Glu 
                485                 490                 495     


Arg Ser Lys Ile Asn Gly Val Lys Leu Glu Glu Asn Thr Thr Tyr Lys 
            500                 505                 510         


Ile Leu Ser Ile Tyr Ser Thr Val Ala Ala Ser Leu 
        515                 520                 


<210>  20
<211>  517
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  20

Asp Lys Ile Cys Ile Gly His Gln Ser Thr Asn Ser Thr Glu Thr Val 
1               5                   10                  15      


Asp Thr Leu Thr Glu Thr Asn Val Pro Val Thr His Ala Lys Glu Leu 
            20                  25                  30          


Leu His Thr Glu His Asn Gly Met Leu Cys Ala Thr Ser Leu Gly His 
        35                  40                  45              


Pro Leu Ile Leu Asp Thr Cys Thr Ile Glu Gly Leu Val Tyr Gly Asn 
    50                  55                  60                  


Pro Ser Cys Asp Leu Leu Leu Gly Gly Arg Glu Trp Ser Tyr Ile Val 
65                  70                  75                  80  


Glu Arg Ser Ser Ala Val Asn Gly Thr Cys Tyr Pro Gly Asn Val Glu 
                85                  90                  95      


Asn Leu Glu Glu Leu Arg Thr Leu Phe Ser Ser Ala Ser Ser Tyr Gln 
            100                 105                 110         


Arg Ile Gln Ile Phe Pro Asp Thr Thr Trp Asn Val Thr Tyr Thr Gly 
        115                 120                 125             


Thr Ser Arg Ala Cys Ser Gly Ser Phe Tyr Arg Ser Met Arg Trp Leu 
    130                 135                 140                 


Thr Gln Lys Ser Gly Phe Tyr Pro Val Gln Asp Ala Gln Tyr Thr Asn 
145                 150                 155                 160 


Asn Arg Gly Lys Ser Ile Leu Phe Val Trp Gly Ile His His Pro Pro 
                165                 170                 175     


Thr Tyr Thr Glu Gln Thr Asn Leu Tyr Ile Arg Asn Asp Thr Thr Thr 
            180                 185                 190         


Ser Val Thr Thr Glu Asp Leu Asn Arg Thr Phe Lys Pro Val Ile Gly 
        195                 200                 205             


Pro Arg Pro Leu Val Asn Gly Leu Gln Gly Arg Ile Asp Tyr Tyr Trp 
    210                 215                 220                 


Ser Val Leu Lys Pro Gly Gln Thr Leu Arg Val Arg Ser Asn Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Pro Trp Tyr Gly His Val Leu Ser Gly Gly Ser His Gly 
                245                 250                 255     


Arg Ile Leu Lys Thr Asp Leu Lys Gly Gly Asn Cys Val Val Gln Cys 
            260                 265                 270         


Gln Thr Glu Lys Gly Gly Leu Asn Ser Thr Leu Pro Phe His Asn Ile 
        275                 280                 285             


Ser Lys Tyr Ala Phe Gly Thr Cys Pro Lys Tyr Val Arg Val Asn Ser 
    290                 295                 300                 


Leu Lys Leu Ala Val Gly Leu Arg Asn Val Pro Ala Arg Ser Ser Arg 
305                 310                 315                 320 


Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Pro Gly 
                325                 330                 335     


Leu Val Ala Gly Trp Tyr Gly Phe Gln His Ser Asn Asp Gln Gly Val 
            340                 345                 350         


Gly Met Ala Ala Asp Arg Asp Ser Thr Gln Lys Ala Ile Asp Lys Ile 
        355                 360                 365             


Thr Ser Lys Val Asn Asn Ile Val Asp Lys Met Asn Lys Gln Tyr Glu 
    370                 375                 380                 


Ile Ile Asp His Glu Phe Ser Glu Val Glu Thr Arg Leu Asn Met Ile 
385                 390                 395                 400 


Asn Asn Lys Ile Asp Asp Gln Ile Gln Asp Val Trp Ala Tyr Asn Ala 
                405                 410                 415     


Glu Leu Leu Val Leu Leu Glu Asn Gln Lys Thr Leu Asp Glu His Asp 
            420                 425                 430         


Ala Asn Val Asn Asn Leu Tyr Asn Lys Val Lys Arg Ala Leu Gly Ser 
        435                 440                 445             


Asn Ala Met Glu Asp Gly Lys Gly Cys Phe Glu Leu Tyr His Lys Cys 
    450                 455                 460                 


Asp Asp Gln Cys Met Glu Thr Ile Arg Asn Gly Thr Tyr Asn Arg Arg 
465                 470                 475                 480 


Lys Tyr Arg Glu Glu Ser Arg Leu Glu Arg Gln Lys Ile Glu Gly Val 
                485                 490                 495     


Lys Leu Glu Ser Glu Gly Thr Tyr Lys Ile Leu Thr Ile Tyr Ser Thr 
            500                 505                 510         


Val Ala Ser Ser Leu 
        515         


<210>  21
<211>  524
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  21

Asp Glu Ile Cys Ile Gly Tyr Leu Ser Asn Asn Ser Thr Asp Lys Val 
1               5                   10                  15      


Asp Thr Ile Ile Glu Asn Asn Val Thr Val Thr Ser Ser Val Glu Leu 
            20                  25                  30          


Val Glu Thr Glu His Thr Gly Ser Phe Cys Ser Ile Asn Gly Lys Gln 
        35                  40                  45              


Pro Ile Ser Leu Gly Asp Cys Ser Phe Ala Gly Trp Ile Leu Gly Asn 
    50                  55                  60                  


Pro Met Cys Asp Asp Leu Ile Gly Lys Thr Ser Trp Ser Tyr Ile Val 
65                  70                  75                  80  


Glu Lys Pro Asn Pro Thr Asn Gly Ile Cys Tyr Pro Gly Ile Leu Glu 
                85                  90                  95      


Asn Glu Glu Glu Leu Arg Leu Lys Phe Ser Gly Val Leu Glu Phe Asn 
            100                 105                 110         


Lys Phe Glu Ala Phe Thr Ser Asn Gly Trp Gly Ala Val Asn Ser Gly 
        115                 120                 125             


Ala Gly Val Thr Ala Ala Cys Lys Phe Gly Ser Ser Asn Ser Phe Phe 
    130                 135                 140                 


Arg Asn Met Ile Trp Leu Ile His Gln Ser Gly Thr Tyr Pro Val Ile 
145                 150                 155                 160 


Lys Arg Thr Phe Asn Asn Thr Lys Gly Arg Asp Val Leu Val Val Trp 
                165                 170                 175     


Gly Ile His His Pro Ala Thr Leu Lys Glu His Gln Asp Leu Tyr Lys 
            180                 185                 190         


Lys Asp Ser Ser Tyr Val Ala Val Gly Ser Glu Thr Tyr Asn Arg Arg 
        195                 200                 205             


Phe Thr Pro Glu Ile Ser Thr Arg Pro Lys Val Asn Gly Gln Ala Gly 
    210                 215                 220                 


Arg Met Thr Phe Tyr Trp Thr Ile Val Lys Pro Gly Glu Ser Ile Thr 
225                 230                 235                 240 


Phe Glu Ser Asn Gly Ala Phe Leu Ala Pro Arg Tyr Ala Phe Glu Ile 
                245                 250                 255     


Val Ser Val Gly Asn Gly Lys Leu Phe Arg Ser Glu Leu Asn Ile Glu 
            260                 265                 270         


Ser Cys Ser Thr Lys Cys Gln Thr Glu Val Gly Gly Ile Asn Thr Asn 
        275                 280                 285             


Lys Ser Phe His Ser Val His Arg Asn Thr Ile Gly Asp Cys Pro Lys 
    290                 295                 300                 


Tyr Val Asn Val Lys Ser Leu Lys Leu Ala Thr Gly Leu Arg Asn Val 
305                 310                 315                 320 


Pro Ala Ile Ala Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
                325                 330                 335     


Glu Gly Gly Trp Pro Gly Leu Ile Asn Gly Trp Tyr Gly Phe Gln His 
            340                 345                 350         


Arg Asn Glu Glu Gly Thr Gly Ile Ala Ala Asp Lys Glu Ser Thr Gln 
        355                 360                 365             


Lys Ala Ile Asp Gln Ile Thr Ser Lys Val Asn Asn Ile Val Asp Arg 
    370                 375                 380                 


Met Asn Thr Asn Phe Glu Ser Val Gln His Glu Phe Ser Glu Ile Glu 
385                 390                 395                 400 


Glu Arg Ile Asn Arg Leu Ser Lys His Val Asp Asp Ser Val Val Asp 
                405                 410                 415     


Ile Trp Ser Tyr Asn Ala Gln Leu Leu Val Leu Leu Glu Asn Glu Lys 
            420                 425                 430         


Thr Leu Asp Leu His Asp Ser Asn Val Arg Asn Leu His Glu Arg Val 
        435                 440                 445             


Arg Arg Met Leu Lys Asp Asn Ala Lys Asp Glu Gly Asn Gly Cys Phe 
    450                 455                 460                 


Thr Phe Tyr His Lys Cys Asp Asn Glu Cys Ile Glu Lys Val Arg Asn 
465                 470                 475                 480 


Gly Thr Tyr Asp His Lys Glu Phe Glu Lys Glu Ser Lys Ile Asn Arg 
                485                 490                 495     


Gln Glu Ile Glu Gly Val Lys Leu Asp Ser Ser Gly Asn Val Tyr Lys 
            500                 505                 510         


Ile Leu Ser Ile Tyr Ser Cys Ile Ala Ser Ser Leu 
        515                 520                 


<210>  22
<211>  522
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  22

Asp Arg Ile Cys Val Gly Tyr Leu Ser Thr Asn Ser Ser Glu Arg Val 
1               5                   10                  15      


Asp Thr Leu Leu Glu Asn Asn Val Pro Val Thr Ser Ser Val Asp Leu 
            20                  25                  30          


Val Glu Thr Asn His Thr Gly Thr Tyr Cys Ser Leu Gly Gly Ile Ser 
        35                  40                  45              


Pro Val His Leu Gly Asp Cys Ser Phe Glu Gly Trp Ile Val Gly Asn 
    50                  55                  60                  


Pro Ala Cys Ala Ser Asn Leu Gly Ile Arg Glu Trp Ser Tyr Leu Ile 
65                  70                  75                  80  


Glu Asp Pro Ser Ala Pro His Gly Leu Cys Tyr Pro Gly Glu Leu Asp 
                85                  90                  95      


Asn Asn Gly Glu Leu Arg His Leu Phe Ser Gly Ile Arg Ser Phe Ser 
            100                 105                 110         


Arg Thr Glu Leu Ile Ala Pro Thr Ser Trp Gly Ala Val Asn Asp Gly 
        115                 120                 125             


Val Ser Ser Ala Cys Gln Asp Lys Gly Ala Ser Ser Phe Tyr Arg Asn 
    130                 135                 140                 


Leu Val Trp Phe Val Glu Arg Gly Asn Lys Tyr Pro Val Ile Arg Gly 
145                 150                 155                 160 


Thr Tyr Asn Asn Thr Thr Gly Arg Asp Val Leu Val Ile Trp Gly Ile 
                165                 170                 175     


His His Pro Val Ser Thr Asp Glu Ala Arg Lys Leu Tyr Val Asn Asp 
            180                 185                 190         


Asn Pro Tyr Thr Leu Val Ser Thr Ser Ser Trp Ser Arg Lys Tyr Asn 
        195                 200                 205             


Leu Glu Ile Gly Ile Arg Pro Gly Tyr Asn Gly Gln Lys Ser Trp Met 
    210                 215                 220                 


Lys Ile Tyr Trp Tyr Leu Met His Pro Gly Glu Ser Ile Ser Phe Glu 
225                 230                 235                 240 


Ser Asn Gly Gly Leu Leu Ala Pro Lys Tyr Gly Tyr Ile Ile Glu Glu 
                245                 250                 255     


Tyr Gly Lys Gly Arg Ile Phe Gln Ser Arg Ile Arg Ile Ala Lys Cys 
            260                 265                 270         


Asn Thr Lys Cys Gln Thr Ser Val Gly Gly Ile Asn Thr Asn Lys Thr 
        275                 280                 285             


Phe Gln Asn Ile Glu Arg Asn Ala Leu Gly Asp Cys Pro Lys Tyr Ile 
    290                 295                 300                 


Lys Ser Gly Gln Leu Lys Leu Ala Thr Gly Leu Arg Asn Val Pro Ala 
305                 310                 315                 320 


Ile Ser Lys Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly 
                325                 330                 335     


Gly Trp Pro Gly Leu Ile Asn Gly Trp Tyr Gly Phe Gln His Gln Asn 
            340                 345                 350         


Glu Gln Gly Val Gly Met Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala 
        355                 360                 365             


Ile Asp Gln Ile Thr Thr Lys Ile Asn Asn Ile Ile Glu Lys Met Asn 
    370                 375                 380                 


Gly Asn Tyr Asp Ser Ile Arg Gly Glu Phe Ser Gln Val Glu Gln Arg 
385                 390                 395                 400 


Ile Asn Met Leu Ala Asp Arg Ile Asp Asp Ala Val Thr Asp Val Trp 
                405                 410                 415     


Ser Tyr Asn Ala Lys Leu Leu Val Leu Leu Glu Asn Asp Lys Thr Leu 
            420                 425                 430         


Asp Met His Asp Ala Asn Val Arg Asn Leu His Asp Gln Val Arg Arg 
        435                 440                 445             


Val Leu Lys Thr Asn Ala Ile Asp Glu Gly Asn Gly Cys Phe Glu Leu 
    450                 455                 460                 


Leu His Lys Cys Asn Asp Ser Cys Met Glu Thr Ile Arg Asn Gly Thr 
465                 470                 475                 480 


Tyr Asn His Thr Glu Tyr Glu Glu Glu Ser Lys Leu Lys Arg Gln Glu 
                485                 490                 495     


Ile Glu Gly Ile Lys Leu Lys Ser Asp Asp Ser Val Tyr Lys Ala Leu 
            500                 505                 510         


Ser Ile Tyr Ser Cys Ile Ala Ser Ser Ile 
        515                 520         


