                               SEQUENCE LISTING

<110>  MINA THERAPEUTICS LIMITED
 
<120>  STABILIZED CEBPA SARNA COMPOSITIONS AND METHODS OF USE

<130>  2058.1021PCT

<150>  US62/555951
<151>  2017-09-08

<160> 23

<170> PatentIn version 3.5

<210> 1
<211> 4001
<212> DNA
<213> Homo sapiens

<400> 1
tccctctccc accaggggta tacatcctca gagctgaccc acgacctagc tttctggtgt       60

gactcggggt gggggctccc actggtcacc tggtgacccc catcgcagtg agttccgccc      120

caaggggaag cccagcctat agcaggctgg ggtggggtgt gtgcggaggg aggtgggaga      180

ggcgtggaac tagagaccct ccaccttcat gtagaactag gggaacaacc ttaggttcca      240

agccccaagt ccctatgttt ccaccccttt ctaaggacag gcgtggagga gcggctgggg      300

ctggcgggct tgtcgggatc tcagctccct gagccctcct cctgccacgg gcctgctccc      360

ctccttctct catgggggtc tgctgtagcc tcgggaagga ggcaggaaac ctccaaataa      420

aatgacaagg cacgatttgc tccccctact cagtaggcat tggagcggtg agtttgcatt      480

tccaaggcac aaggttatcc taaatactag agttgccggg ctcccagctc agccccaaga      540

attctcccct cctcgcaggg agaagccacc gcctggcccc ctcatcttag acgcaccaag      600

tccggcgcag aggaagggag gggacacgcg gagcaggcca ggctttcagg aggcaccgga      660

atctcctagt cctggctcgc acggctcggg caagcctcga gatccggcga ccccaaacca      720

ctccctgggt ccccgccgga ggctggccca gggcggtccc acagccgcgc gcctcacgcg      780

cagttgccca tggccttgac caaggagctc tctggcagct ggcggaagat gccccgcagc      840

gtgtccagtt cgcggctcag ctgttccacc cgcttgcgca ggcggtcatt gtcactggtc      900

agctccagca ccttctgctg cgtctccacg ttgcgctgct tggccttgtc gcggctcttg      960

cgcaccgcga tgttgttgcg ctcgcgccgc acccggtact cgttgctgtt cttgtccacc     1020

gacttcttgg ccttgcccgc gccgctgccg ccactcgcgc ggaggtcggg gtgcgcggcg     1080

cccagcccct tgagcgcgct gccagggccc ggcaggccgg cggcaccgag cgcgggcgcg     1140

gggtgcgggc tgggcacggg cgtgggcggc ggcgtggggt gaccgggctg caggtgcatg     1200

gtggtctggc cgcagtgcgc gatctggaac tgcaggtgcg gggcggccag gtgcgcgggc     1260

ggcgggtgcg ggtgcgggtg cgagggcggc ggcggcggcg gcggctggta agggaagagg     1320

ccggccagcg ccagctgctt ggcttcatcc tcctcgcggg gctcctgctt gatcaccagc     1380

ggccgcagcg ccggcgcccc gacgcgctcg tacaggggct ccagcctgcc gtccaggtag     1440

ccggcggccg cgcagccgta gccgggcggg ggcccgtgcg ctcccccggg catgacggcg     1500

ccgccggggc ccgcgggcgc gcccgggtag tcaaagtcgc cgccgccgcc gccgcccgtg     1560

gggcccacgg ccgccttggc cttctcctgc tgccggctgt gctggaacag gtcggccagg     1620

aactcgtcgt tgaaggcggc cgggtcgatg taggcgctga tgtcgatgga cgtctcgtgc     1680

tcgcagatgc cgcccagcgg ctccggggcg gcaggtgggg cgggaggctg cgcggggccc     1740

gcgccccggg gaaagccgaa ggcggcgctg ctgggcgcgt gcggggggct ctgcaggtgg     1800

ctgctcatcg ggggccgcgg ctccgcctcg tagaagtcgg ccgactccat gggggagtta     1860

gagttctccc ggcatggcga gcctcggcgg cctccagcct gcgcggggcg tcgccgccgc     1920

ccacccggag accctgctcg cccgcgcccg cgcacctccg ggtcgcgaat ggcccggccc     1980

gcgccggccc agcttttata cccggcaggc cgcgtcgccc cctagagtcc gaggcggcct     2040

ctgtccccgg gctgcggcgg cgcggcgcct gctgggtcct agcgcgcggc cggcatgggg     2100

cggcgaacca gcgcggcaca gcgccgcgct ccccaggcag gccgcggcgc aacgcccacc     2160

gcctccagcg cgcccagcag agccgcggcg ctcgctccaa gctccgcccc cggcccggcc     2220

gtcgcccccg cgcccacgtg gtcggtagcg ggggccccct cctcctgcct gccctaggcg     2280

cccgtatcca gccacggccg ggagcccagg agtatcccga ggctgcacgg ggtaggggtg     2340

gggggcggag ggcgagtctt ggtcttgagc tgctggggcg cggattctct ttcaaagcca     2400

gaaccaggcc tgtcccggac ccgcgtcccg gggaggctgc agcgcagagc agcggggctg     2460

gggccggtgg ggggccgttt gggacgcgcg gagaggtcct gagcgcggtg gctctgcgtc     2520

tcctagctct gatctccagg ctacccctgt gattccgcgc agaggtacct ctcggaggac     2580

gccggggtcc catgggcggc gccgcgcagg gcgctaggac cccgcgggga gcggaggcgg     2640

cctcggcccg ggagcctgga ggacctggcc ggtcgatccg cccgggctgg aaaactttct     2700

ttataattac ttctccaggt cggagcgcgc ggcttgctag gcgcgcgggg ccggcgctgt     2760

tacccggcgt ggagtcgccg attttttttc ctgcgggacc gcggggcccc ccagactagc     2820

ggagctggac gccggggcga gcacggggag gggcgcaccg agggaggaga caaacttaac     2880

tctggggccg ggattccgag gcgggggccg cagccctcga ggcccgaagc caccgcttcc     2940

tcccccgcct ccccattcag gtgggcgcca acggcgggag cgagggtgtc caggccgccg     3000

ggctgccagg tccgagcacg cacagggaga actctgccca gtggttcgcc gggcgctgta     3060

gtccccggga tcctagggac cgaggcggcc aggccctggg gccccttgag tgcggcagct     3120

aatgctctca ccgcggcggg ggaaggagct tgccaccgag acccccagcc acgtgcgtcc     3180

ctcgcattct ttaccggggc cggggtggcg gctacggacc gtcagctggg cccagatgga     3240

gtcttgggag ccctcaagtg tctcctgtcc ttgcccgcgc cgcccctcgc cactggcgct     3300

gaggcctgac gccgcctgcg tcccggctag aggcgcgctt gcctacaggt gagggaagac     3360

ccccttcacc gacagtggcc ttaggcctgg caaggcgcca cgacccgccc aggagccccg     3420

gagggggcac agctaaaaac accgctggag agccccgagc ttccacgacg atcgcagtaa     3480

agaagcagtt tcatctgggc aacgcacact gcgctttaat caagttccta ttcaacatag     3540

tcccagtgat taatagccca actgcttcgt tttcggtcca gagctcataa acaagatatt     3600

tttagcttga cgcttttgga cgggagggag taaaaaccag atacgttaaa taaatatccc     3660

gatgtgagcc ggagagctgc ttgctgagcc aaatgcagga cccattcata tagcattcac     3720

ctgtggaggg agacctggac ggaaatcaaa aagcaccaag agcgatttgc gtttttttct     3780

gcggtgctaa aactaatggc ttttcctacc taggaacaaa gaaacgccac tgtacatgca     3840

cggttcccgg cctgtggagt tgtgggagga aggcgatgtc tggccttttt tgcacagctg     3900

ctgttgcctg cccagagatc gggaactctg ccccgtagga ctggaagaaa cctcagtaat     3960

gggaataaga ctttgtccaa tagggggctg atgaatgtgt g                         4001


<210> 2
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
gcggucauug ucacuggucu u                                                 21


<210> 3
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
gaccagugac aaugaccgcu u                                                 21


<210> 4
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5' NH2-(C6H12)-linker 

<220>
<221> modified_base
<222> (22)..(22)
<223> Inverted nucleotide 

<400> 4
gcggucauug ucacuggucu ut                                                22


<210> 5
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<400> 5
gaccagugac aaugaccgcu u                                                 21


<210> 6
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5' NH2-(C6H12)-linker 

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> Inverted nucleotide 

<400> 6
gcggucauug ucacuggucu ut                                                22


<210> 7
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (19)..(21)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<400> 7
gaccagugac aaugaccgcu u                                                 21


<210> 8
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5' NH2-(C6H12)-linker 

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> Inverted nucleotide 

<400> 8
gcggucauug ucacuggucu ut                                                22


<210> 9
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (19)..(21)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (19)..(21)
<223> Phosphorothioate linkage

<400> 9
gaccagugac aaugaccgcu u                                                 21


<210> 10
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5' NH2-(C6H12)-linker 

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (9)..(11)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> Inverted nucleotide 

<400> 10
gcggucauug ucacuggucu ut                                                22


<210> 11
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (9)..(11)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (19)..(21)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (19)..(21)
<223> Phosphorothioate linkage 

<400> 11
gaccagugac aaugaccgcu u                                                 21


<210> 12
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5' NH2-(C6H12)-linker 

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (9)..(11)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> Inverted nucleotide 

<400> 12
gcggucauac acacuggucu ut                                                22


<210> 13
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (9)..(11)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (19)..(21)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (19)..(21)
<223> Phosphorothioate linkage 

<400> 13
gaccagugug uaugaccgcu u                                                 21


<210> 14
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5' NH2-(C6H12)-linker 

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (7)..(9)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> Inverted nucleotide 

<400> 14
gcggucauug ucacuggucu ut                                                22


<210> 15
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (11)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (19)..(21)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (19)..(21)
<223> Phosphorothioate linkage 

<400> 15
gaccagugac aaugaccgcu u                                                 21


<210> 16
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5' NH2-(C6H12)-linker 

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (19)..(21)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> Inverted nucleotide 

<400> 16
gcggucauug ucacuggucu ut                                                22


<210> 17
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-Fluoro nucleotide

<220>
<221> misc_feature
<222> (19)..(21)
<223> Phosphorothioate linkage 

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide 

<400> 17
gaccagugac aaugaccgcu u                                                 21


<210> 18
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (7)..(9)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide 

<220>
<221> modified_base
<222> (22)..(22)
<223> Inverted nucleotide

<400> 18
gcggucauug ucacuggucu ut                                                22


<210> 19
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (11)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (19)..(21)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (19)..(21)
<223> Phosphorothioate linkage 

<400> 19
gaccagugac aaugaccgcu u                                                 21


<210> 20
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted nucleotide 

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro nucleotide

<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (8)..(10)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (21)..(22)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> Inverted nucleotide 

<400> 20
tgcggucauu gucacugguc uut                                               23


<210> 21
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (11)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (19)..(21)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (19)..(21)
<223> Phosphorothioate linkage 

<400> 21
gaccagugac aaugaccgcu u                                                 21


<210> 22
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (1)..(2)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 22
gcggucauug ucacuggucu u                                                 21


<210> 23
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 23
gaccagugac aaugaccgcu u                                                 21

