                               SEQUENCE LISTING

<110>  MINA THERAPEUTICS LIMITED
 
<120>  HNF4A SARNA COMPOSITIONS AND METHODS OF USE

<130>  2058.1020PCT1

<150>  US62/555,937
<151>  2017-09-08

<150>  US62/555,951
<151>  2017-09-08

<150>  PCT/EP2017/074130
<151>  2017-09-22

<160> 144   

<170> PatentIn version 3.5

<210> 1
<211> 4001
<212> DNA
<213> Homo sapiens

<400> 1
tctttctggt tccagagctg gaggtggtct tgtctttggg actcccagtt caggggcttg       60

gcctctgcct caggagcaca cagttcctgg gcttggaaaa agtgatgggg gcggggagca      120

gcccagggca gggcagtggt cctcgtgggg ccacacaaca ctccacctag tgcagcagca      180

gcttgtttgc tatctctggt gtgtttttgc cttgcgctcc tggcgtggtc ctcagacagg      240

cctaaaagcc gtccagccag caggcctggg ggaatgaagc ctgttttgta gaagatacag      300

aagccaggat aggggaggtg acatgcccaa ggtcacacgt gactggacgg caggggcagg      360

tgagcacctg ctgagctgac aacaagcagt gcccagcagc tgcctcctca ccctagctga      420

gctgaccaca agattccaga cctcagctgg agctgcagcc tcatactggc tgagtggctc      480

caagacacag aaggaagcag ggtggcaggc tgacctcagc cagctgcctg ccccctctcc      540

tctgaggctg gcctgggacc gatggggctc ttccctccag gaggggtttc cgggcctcct      600

cttttcccct acctccctgt ggagaactgt ccacccctcc agatatgctc cagtgatgtc      660

ggaggggatg cctcaatctg gcgagacgca gcggcaacaa aatctgctca gagacaaacg      720

gacatgttgc tgatatgaat ctcacttggt gagtggcaac aacagagtcc tgcatttggg      780

tctgtgcagt cgtgcacacc agagaccgct gacccccgcc cgcagcacag ggaactgcat      840

atatacacag caggtacaaa tatgggcaca cgacaaaacg cccatacagg ataaagatgc      900

aggaagaaca gggcactcca acaggtccgc atgcacaaac gcatgtgctc tatgacccgc      960

acacacagca cacatgtaca aacatccaca gacacaagta cacacacata cacacttaca     1020

tacataagca agatcaacac gggcaactcc taagacacaa acacagaccc actcaatgaa     1080

tacaaaggaa aatagaccca gaactcacac acagagacaa atgaacacac atatgcaaat     1140

gggttcctga aggcatcacc ccacccatac aacctacatg gaaactcact atcacacacg     1200

aacgcacaca caacacacac agtgctgagt tggcttcgta gttagcaaaa cttccctgag     1260

agctccattt tccctaagtg ccaatttcat ttccctagga aagtcccaaa gacaccgaga     1320

aatgcggtta tgtctccaac caccatctcc agggatacaa catcccttgc cgtctctctg     1380

aacctaggcc caaggggttc acgaaggggc cgtgctgggc tgaatcgctg gagctgggca     1440

ccaaggggga gctcaccatc acgtcactgt gccaagcgcc aagcagagcc actgtgaggc     1500

agtgaggact ggaagggcct gggaggaata gccgggatcg acttttgctg gaaattggcc     1560

cttgcaggcc tcccttcacc cagaatgcct gtgatcactg tgcctgggca catgggcttc     1620

acttggcaac acctgtgctg gcctgtagga ccaacctacc attttgtatc attctcctcc     1680

caccccaaag ttgagtgcca aagatctgct cctggaccca ggcacacctg cccccactgg     1740

cacacctggg cacatctgcc cccacctacc attgcccatc gtcaacacct gcacattctc     1800

aaattccagg gtggtgtagg ctgggtccag tgcagcactg tagtcggcca tgtccatgtc     1860

gacgagggtt ttggagagtc gcattctccc tgcctccacg ccgcggccac ctgccctacc     1920

ctgggcgccc accccgaagg cccccgccct ccgccctccc actgcctcct cccagtgccc     1980

tctctgcctt cctttcaaac cgtcctctgg gaagatctgc tgggagtctt ggcctagcct     2040

ctgtgaaggg gtggaggctc tgccggggag gggtgggggt taatggttaa tcggtccccc     2100

gccggtggat aggctgggcg gggctgcagg gatttggctg tttgttggtt tctggctgac     2160

acccggggtg ctaattacaa ctgctggggc cctaactcac cgatgttcag ttatcaattg     2220

tacaaggcag gcatcatgac tcacgggcac tcatttgacc cttgactcac ccacccctcc     2280

aagccattgt caccccaagt caggcattct aactgatact atcaggcact gacagcctac     2340

ctccgagatc ccctaattca ataacttccc aaatcattga cttctaccct caatgctttt     2400

gcagagataa ggctgcccca tggcccacga tttagaaacc taaatcccag gccccagatg     2460

ccaatcttct ggatccttgt tctgggagct cccttccagt tcccccgcag tttcccggtt     2520

cccctgggag cagaatggac tggaagtttg ggagggccag attcacctcc aattccccgc     2580

tcctgctccc tgtgatccca ccctgcccct ctccgtctcc cacagctccc agtgtttctg     2640

gcccaggctg gctccatctc ggattttccc atcacattct cctgtttccc tcacccccac     2700

cccctcccgg agcaggcaga gacctggatt tacattcagg cacctaccgt ctactaactg     2760

ggaccttggg taaatgattc tcctctccga gcctcagttt ccttttctgt aaaatgtaca     2820

atcaacttca aagggtggtt tgagaaggaa atgagatggc ataaatcaag caccaagtgg     2880

ggcctggtag acgtccatcc tcttccccct cctccctctc cctgtttcgt atcccccttg     2940

ccatccccct gtttctctcc acccgtctcc taccttcaga gtgggctttg tgggggtatc     3000

gccagtgcag tcacaggcaa cccaaccctt agaaagtcct ggttcctggt tcagtgctct     3060

gctgtggttg tcctaaaatt catcatgact tttgaacaag ggattgtgca tttttgtttt     3120

ggacggggcc ctgaaaatta cacagctggt cctggctgtc tgaagctcat ggtgcactct     3180

gttcttctca ctccctccag ccctcattgc cttctgtgca gacattttca agggctgcca     3240

atcaatctgg ggaagtaaag tcttgatgta gaaggcagag agtgagggca gaggaagaaa     3300

agcctgagac ttgggaggcc tgggagcctg tcctccactg ctggctggaa gggcaggttg     3360

gagggcctcg gtgacacctg tgagcaagag tgggcgaatt agtgggagca ccaattaatg     3420

agtgagtgtg tgggggaatt gatgagtggg tgaattagga gtgagtgaat tagagacagg     3480

gagaattaat gagtgagttg agtgaatgca tgaatgagtg agtgaatgaa cgaatgaggg     3540

taaattactg agtaagtgag caaatgggtg ggtgaattaa tgagtgaatg ggtgggtgaa     3600

ttaatgagtg agtgaatgag tgaatgtgtg ggtggattaa tgagtgagca aatcgggagt     3660

cagggcatgt gtgttcgagt ggtatgagga ggcatcttca tgttctttcc actgctagaa     3720

gccctttctc tgccctgctt agctttattc tgtccacttg atctgacctc tgaagctgag     3780

atgactgggg agtgctattg cctgtaggga aaggggagag ggagcaactg ttgtggagga     3840

caagagaggc tagatttgat gtcaggagac ctggggttag gaactagctc agtcactatt     3900

ccgataactt tatttacatc gtctcttctc agggcttcaa tttctccctc tgtaaaatag     3960

aaagatgatc ctggctcagt tttctgttag ccaggacaag a                         4001


<210> 2
<211> 4001
<212> DNA
<213> Homo sapiens

<400> 2
caatattatt tatctcagac agccgtttgg aaaatgaaac agctgtctga gagataatag       60

tagaacattc actaacccat tcatccatcc attcacccac ctacctgtcg atagaagcaa      120

ccattctaat aattgctgaa tgtttgctat ataatgagta tgacacagga gcagagatga      180

agagacatga ggacatccta caaggtgcag agacgtggga gacagtgaaa ggctgtcagg      240

ttatattatt gtatcatcct ttaagagaca ctgtggggcc ttctgttcac ccctagctta      300

gccttatgac ctgggctgtc cttccccaga agctgtctgg cccctttgag agacaatgtc      360

ttcccctagc cacaggttca accaagtcat ccattggcat ctatactcca ggtcttaaaa      420

ttgtggatta agggtggcct cacccttaat ctcctctatg ctatctcctc taatctcccc      480

gctctctggg agataggtcc tgttgttatc ttcattttac agatgaggaa ataggttcag      540

agaggggaaa tgtcttgccc aaggtcacac agctggtgtg tgggatgggt tcccaggctg      600

ttggtttctt cagcctctgc catttccagt gcatcacata ttcctgtttg atgggggtca      660

aagcaaagaa gattcttcct gactagagtc aggagatcag gccctgattc tgtcattccc      720

tggccctctg tcctcagcaa ttgatgacat aaatgttgat tgtgtctttg caatgcacgt      780

ggtatcaagg gctttacatc cttgttcccc acggcatcca ccatgatctt aagacacatc      840

ctagtcctgt ctccacttca gaaagaaagc aagaggcacg tgaatgttga gccgtgtgac      900

agagtcacaa ctagaccccg aggtctgctg gattccagag accaagttct gtgcgggtgt      960

gtgatttgaa caggtttata aaaggcaccc aacttttaaa aaatccaaaa tgtgtcccca     1020

aaagataaaa cattctcttg aatttccctc ctcagaaaca aacctgtcac caattttatt     1080

gtgtcattcc acgaattttc tatgcgtgga atgtacacgt atacgcgtgt gtacatatat     1140

acatctatat ccgtttcgct atcagcaact acacagttct tcagtgtacc gttttcactt     1200

aatttaactg agaggttctt ccctgtcaca cacagatgtg cgttgtttcc ttgaacaatg     1260

ggatagcatt ccactgtaaa gacgtctcac gctttattta cccgtcttcc ctctgctgag     1320

ggacattggg ttgcttccaa tgtgggggtc accctaagga gtgagcctga gcctttcact     1380

ctcagtaaca catgctttct agccctgcat ctgagtttca cacgtccgca caagatattc     1440

tcattttcca acgctccacc ctgcgcggcg ctttctacct cctccccatt atccagagcc     1500

aacggaggtg cggagcgacc gagctgcccg gtcccacgcc cagcttgata atgcaccagc     1560

aacgtgacct aggcccagca agcctctcct ggtggacctc aatttgcccc gcatcgaaac     1620

aggacggtgc ttccaagccc caccctctgt ggggttttgg aaagacccct gagatgcatt     1680

cccaggaagg cctctggaca gacaaaatga gccaagcctc tgccccaggg cttctcggcc     1740

cctcccagca cttctcgcac caagcaggcc atgccccggc ttgagagctt agggaagcgg     1800

tcacattgcc tccgtggggc ttcctgccct tccagaggag ctccaggagg agctttgggc     1860

ccgtaagaaa cacacgggga ggtgtcccat ggcctcccaa agctgaccgc agtcccgccc     1920

tgtccagtct tcccccagcc ccacttaccg taagaactct ccactggagc cccgaggggc     1980

gcgttcacgc tgaccatggc caagcccacc cagccggaga gctgggggca tggaggagca     2040

ggggcccgct cacagcagca gcacagccac caggagcccg tccaccagga aggcggtgag     2100

tgcggccagc tgccaccgcc cggttatctt attgattctt ctaatcaccc aaggtgggtg     2160

gatacgttaa agagtaacca gtcacttagg gaacccgcgg ctggggactg ttgctgtctc     2220

catggcaatg gcgacctggc cagacctgag gtccactcgg gtcctagtcc tgcactctgg     2280

ggttagggga acccagagcc aggtgtatgg ggacatcagc cccccaattt gaggacaggg     2340

ccggagcaga aggggctgga gaggtgagag tccaacctgg gttgggtttt atggctccaa     2400

actatgggtg tgtcaccatg caggaagtag tgggaaaacc gagggagggg cagaggaaaa     2460

aaggagggtg gagaactgtg tttagtgagt gcctactgga tgctgggagt tgcatacagg     2520

cgttaccata tttaaattaa accttgagat gaagggactg aaggacagag agaaattgca     2580

tgcctggagt ctcactgcta gtacatagag gtgttatctt cctttcatct aacatattta     2640

ttgagcacct actatgtacc aggccttgtg ctagactctg gggatatgga aatgagcaaa     2700

gtagatgtac ccccgaaact tgtggactaa tggaggagac ggaccttaat cagatcgtca     2760

ttcaaagata ctattacaaa ctggtgagtg atatgagggg tggagaaaca tggggctgcc     2820

tccaggccaa tgggacaaag tcatcctgtc tggcgtctcc tctggtctcc ttccccattc     2880

taaattcaac ctgctgctga aactcacaca ctctgtttta gctccctggc atgttagaca     2940

cctgccacct agcttttttt ttggaacagc cccgtttctt ttgtctcagt tttggatctc     3000

accacctgct tggggattct gaaatcaagg tcattcatcc tgttagagag agctgaaatg     3060

agaacagtga aacaaattct ggactcagaa aaatcagaaa actccagctc tattattttc     3120

ttgctgtatg ttttttagta aattatttca tttccttata ggaataccta gctcatagtt     3180

tgccctgctt ctaaaatagc taattgataa tattcctctt ctcttcccat agtctctttt     3240

ttcagcttta tcaatcacct cagagggacc ttcagcccct acagatgggc atgggttgca     3300

ttaaaatgtc ctttcttttc taaaacaaca gtgataacaa acgttagatt ttggggccgg     3360

gtgcagtggc tcacgcctgt aaccccagca ttttgggagg ccgaggcgca ccgatcacga     3420

ggtcaggagt ttgaggccag cctgaccaac atggtgaaac cccgtctcta ccaaaaataa     3480

aaaaattagc cgggcatggt ggcaaacggg aggctgaggc aagagaatcg tttgaaccag     3540

ggggacagag gttgcagtga gccaagatcg tgccactgca ctccagcctg ggcaacagag     3600

agagactcca tctcaaaata aataaataaa taaataaata aataaataaa taaataactt     3660

cgatattttt taaaaaaaag tattaatatt cttggtcggg tgtagtggct catgcctgta     3720

atcccagcag tttgggaggc tgaggcaggt ggatcacttg aggtcaggag tttgagacca     3780

ggctggccaa cacggtgtaa tcccatctct actaaaaata caaaaattag ctgggtgtgg     3840

cagcgagcac ctgtaatctc agctactcgg gaggctgaag gaggagaatc gtttcaacct     3900

aggaggcaaa tgttgcagtg agccaagatt gcactactgc actgcagcct tggcgacaga     3960

gccagactcc atctcagaaa aaaaaaaagt attaatattt t                         4001


<210> 3
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
gagcuuuggg cccguaaga                                                    19


<210> 4
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
ucuuacgggc ccaaagcuc                                                    19 


<210> 5
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
gguggauacg uuaaagagu                                                    19


<210> 6
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
acucuuuaac guauccacc                                                    19


<210> 7
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
cccagaaugc cugugauca                                                    19


<210> 8
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
ugaucacagg cauucuggg                                                    19


<210> 9
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
ccgauguuca guuaucaau                                                    19


<210> 10
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
auugauaacu gaacaucgg                                                    19


<210> 11
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
gaagauugcu cgugcaaau                                                    19


<210> 12
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
auuugcacga gcaaucuuc                                                    19


<210> 13
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
cagauaugcu ccagugaug                                                    19


<210> 14
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
caucacugga gcauaucug                                                    19


<210> 15
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
auaccacucg aacacacau                                                    19


<210> 16
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
auguguguuc gagugguau                                                    19


<210> 17
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
uacucaguaa uuuacccuc                                                    19


<210> 18
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
gaggguaaau uacugagua                                                    19


<210> 19
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
ucauaucagc aacaugucc                                                    19


<210> 20
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
ggacauguug cugauauga                                                    19


<210> 21
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
ucuccugaca ucaaaucua                                                    19


<210> 22
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
uagauuugau gucaggaga                                                    19


<210> 23
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
ucacucacuc cuaauucac                                                    19


<210> 24
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
gugaauuagg agugaguga                                                    19


<210> 25
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
agacauaacc gcauuucuc                                                    19


<210> 26
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
gagaaaugcg guuaugucu                                                    19


<210> 27
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
aacacaccag agauagcaa                                                    19


<210> 28
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
uugcuaucuc ugguguguu                                                    19


<210> 29
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
ucgaucccgg cuauuccuc                                                    19


<210> 30
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
gaggaauagc cgggaucga                                                    19


<210> 31
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
uuuggcacuc aacuuuggg                                                    19


<210> 32
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
cccaaaguug agugccaaa                                                    19


<210> 33
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-OMe modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-OMe modified nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-OMe modified nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> Phosphorothioate linkage

<400> 33
ucgaaguacu uagcguaagt t                                                 21


<210> 34
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-OMe modified nucleotide

<220>
<221> modified_base
<222> (7)..(8)
<223> 2'-OMe modified nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-OMe modified nucleotide

<220>
<221> modified_base
<222> (14)..(17)
<223> 2'-OMe modified nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> Phosphorothioate linkage

<400> 34
cuuacgcuga guacuucgat t                                                 21


<210> 35
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<400> 35
uucauuaagc cuugagacau u                                                 21


<210> 36
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<400> 36
ugucucaagg cuuaaugaau u                                                 21


<210> 37
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 37
auugacuucu acccucaauu u                                                 21


<210> 38
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 38
auugagggua gaagucaauu u                                                 21


<210> 39
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 39
ugggugaauu aaugagugau u                                                 21


<210> 40
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 40
ucacucauua auucacccau u                                                 21


<210> 41
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 41
cagggauuug gcuguuuguu u                                                 21


<210> 42
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 42
acaaacagcc aaaucccugu u                                                 21


<210> 43
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 43
gcccgguuau cuuauugauu u                                                 21


<210> 44
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 44
aucaauaaga uaaccgggcu u                                                 21


<210> 45
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 45
guggauacgu uaaagaguau u                                                 21


<210> 46
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 46
uacucuuuaa cguauccacu u                                                 21


<210> 47
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 47
acgcgugugu acauauauau u                                                 21


<210> 48
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 48
uauauaugua cacacgcguu u                                                 21


<210> 49
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 49
auaccacucg aacacacauu u                                                 21


<210> 50
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 50
auguguguuc gagugguauu u                                                 21


<210> 51
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 51
uacucaguaa uuuacccucu u                                                 21


<210> 52
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 52
gaggguaaau uacugaguau u                                                 21


<210> 53
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 53
ucauaucagc aacauguccu u                                                 21


<210> 54
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 54
ggacauguug cugauaugau u                                                 21


<210> 55
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 55
ucuccugaca ucaaaucuau u                                                 21


<210> 56
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 56
uagauuugau gucaggagau u                                                 21


<210> 57
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 57
ucacucacuc cuaauucacu u                                                 21


<210> 58
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 58
gugaauuagg agugagugau u                                                 21


<210> 59
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 59
agacauaacc gcauuucucu u                                                 21


<210> 60
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 60
gagaaaugcg guuaugucuu u                                                 21


<210> 61
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 61
aacacaccag agauagcaau u                                                 21


<210> 62
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 62
uugcuaucuc ugguguguuu u                                                 21


<210> 63
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 63
ucgaucccgg cuauuccucu u                                                 21


<210> 64
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 64
gaggaauagc cgggaucgau u                                                 21


<210> 65
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 65
uuuggcacuc aacuuugggu u                                                 21


<210> 66
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 66
cccaaaguug agugccaaau u                                                 21


<210> 67
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 67
aaaugucugc acagaaggcu u                                                 21


<210> 68
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 68
gccuucugug cagacauuuu u                                                 21


<210> 69
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 69
cuacaucaag acuuuacuuu u                                                 21


<210> 70
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 70
aaguaaaguc uugauguagu u                                                 21


<210> 71
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 71
gauuugcuca cucauuaauu u                                                 21


<210> 72
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 72
auuaaugagu gagcaaaucu u                                                 21


<210> 73
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 73
cacuuacuca guaauuuacu u                                                 21


<210> 74
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 74
guaaauuacu gaguaagugu u                                                 21


<210> 75
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 75
gacucccagc agaucuuccu u                                                 21


<210> 76
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 76
ggaagaucug cugggagucu u                                                 21


<210> 77
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 77
aauucaccca cccauucacu u                                                 21


<210> 78
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 78
gugaaugggu gggugaauuu u                                                 21


<210> 79
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 79
aucuucccag aggacgguuu u                                                 21


<210> 80
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 80
aaccguccuc ugggaagauu u                                                 21


<210> 81
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 81
acacucacuc auuaauuggu u                                                 21


<210> 82
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 82
ccaauuaaug agugaguguu u                                                 21


<210> 83
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 83
cccagaaugc cugugaucau u                                                 21


<210> 84
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 84
ugaucacagg cauucugggu u                                                 21


<210> 85
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 85
cugugaucac ugugccuggu u                                                 21


<210> 86
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 86
ucaggcacag ugaucacagu u                                                 21


<210> 87
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 87
ccugugauca cugugccugu u                                                 21


<210> 88
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 88
uaggcacagu gaucacaggu u                                                 21


<210> 89
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 89
gccugugauc acugugccuu u                                                 21


<210> 90
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 90
uggcacagug aucacaggcu u                                                 21


<210> 91
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 91
ugccugugau cacugugccu u                                                 21


<210> 92
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 92
ugcacaguga ucacaggcau u                                                 21


<210> 93
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 93
augccuguga ucacugugcu u                                                 21


<210> 94
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 94
ucacagugau cacaggcauu u                                                 21


<210> 95
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 95
aaugccugug aucacugugu u                                                 21


<210> 96
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 96
uacagugauc acaggcauuu u                                                 21


<210> 97
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 97
gaaugccugu gaucacuguu u                                                 21


<210> 98
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 98
ucagugauca caggcauucu u                                                 21


<210> 99
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 99
agaaugccug ugaucacugu u                                                 21


<210> 100
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 100
uagugaucac aggcauucuu u                                                 21


<210> 101
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 101
cagaaugccu gugaucacuu u                                                 21


<210> 102
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 102
ugugaucaca ggcauucugu u                                                 21


<210> 103
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 103
ccagaaugcc ugugaucacu u                                                 21


<210> 104
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 104
uugaucacag gcauucuggu u                                                 21


<210> 105
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 105
cccagaaugc cugugaucau u                                                 21


<210> 106
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 106
ugaucacagg cauucugggu u                                                 21


<210> 107
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 107
acccagaaug ccugugaucu u                                                 21


<210> 108
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 108
uaucacaggc auucuggguu u                                                 21


<210> 109
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 109
cacccagaau gccugugauu u                                                 21


<210> 110
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 110
uucacaggca uucugggugu u                                                 21


<210> 111
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 111
ucacccagaa ugccugugau u                                                 21


<210> 112
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 112
ucacaggcau ucugggugau u                                                 21


<210> 113
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 113
uucacccaga augccugugu u                                                 21


<210> 114
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 114
uacaggcauu cugggugaau u                                                 21


<210> 115
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 115
cuucacccag aaugccuguu u                                                 21


<210> 116
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 116
ucaggcauuc ugggugaagu u                                                 21


<210> 117
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 117
ccuucaccca gaaugccugu u                                                 21


<210> 118
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 118
uaggcauucu gggugaaggu u                                                 21


<210> 119
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 119
cccuucaccc agaaugccuu u                                                 21


<210> 120
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 120
uggcauucug ggugaagggu u                                                 21


<210> 121
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 121
ucccuucacc cagaaugccu u                                                 21


<210> 122
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 122
ugcauucugg gugaagggau u                                                 21


<210> 123
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 123
cucccuucac ccagaaugcu u                                                 21


<210> 124
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 124
ucauucuggg ugaagggagu u                                                 21


<210> 125
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 125
ccucccuuca cccagaaugu u                                                 21


<210> 126
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 126
uauucugggu gaagggaggu u                                                 21


<210> 127
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 127
cccagaaugc cugugaucuu u                                                 21


<210> 128
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 128
ugaucacagg cauucugggu u                                                 21


<210> 129
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 129
ucacccagaa ugccuguguu u                                                 21


<210> 130
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 130
ucacaggcau ucugggugau u                                                 21


<210> 131
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 131
ccagaaugcc ugugaucaau u                                                 21


<210> 132
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 132
uugaucacag gcauucuggu u                                                 21


<210> 133
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA molecule: Synthetic
      oligonucleotide


<220>
<223> 5' NH2-(C6H12)-linker 

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (7)..(9)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> Inverted nucleotide 

<400> 133
cccagaaugc cugugaucau ut                                                22


<210> 134
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (11)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (19)..(21)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (19)..(21)
<223> Phosphorothioate linkage

<400> 134
ugaucacagg cauucugggu u                                                 21


<210> 135
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (1)..(2)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 135
cccagaaugc cugugaucau u                                                 21


<210> 136
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 136
ugaucacagg cauucugggu u                                                 21


<210> 137
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (10)..(12)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (17)..(18)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Methyl nucleotide

<400> 137
cccagaaugc cugugaucau                                                   20


<210> 138
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 138
ugaucacagg cauucugggu u                                                 21


<210> 139
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5' NH2-(C6H12)-linker 

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (7)..(9)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> Inverted nucleotide 

<400> 139
ccagaaugcc ugugaucaau ut                                                22


<210> 140
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (11)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoro nucleotide

<220>
<221> modified_base
<222> (19)..(21)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (19)..(21)
<223> Phosphorothioate linkage

<400> 140
uugaucacag gcauucuggu u                                                 21


<210> 141
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (1)..(2)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 141
ccagaaugcc ugugaucaau u                                                 21


<210> 142
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 142
uugaucacag gcauucuggu u                                                 21


<210> 143
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic capped nucleotide

<220>
<221> modified_base
<222> (1)..(2)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (9)..(11)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (13)..(14)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(17)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Methyl nucleotide

<400> 143
ccagaaugcc ugugaucaau u                                                 21


<210> 144
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-O-Methyl nucleotide

<400> 144
uugaucacag gcauucuggu u                                                 21


