                         SEQUENCE LISTING

<110>  Keygene N.V.
 
<120>  Balanced indels

<130>  P6069751pct

<150>  EP 17190057.4
<151>  2017-09-08

<160>  75    

<170>  PatentIn version 3.5

<210>  1
<211>  1980
<212>  DNA
<213>  Solanum lycopersicon

<400>  1
atggcggctg ctgcctcacc atctccatgt ttctccaaaa ccctacctcc atcttcctcc       60

aaatcttcca ccattctacc tagatctacc ttctctttcc acaatcaccc acaaaaagcc      120

tcaccccttc atctcatcca cgctcaacat aatcgtcgtg gttttgccgt tgccaatgtc      180

gtcatatcca ctaccaccca taacgacgtt tctgaacctg aaacattcgt ttcccgtttc      240

gcccctgacg aacccagaaa gggttgtgat gttcttgtgg aggcacttga aagggaaggt      300

gttacggatg tatttgcata cccaggaggt gcttctatgg agattcatca agctttgaca      360

cgttcgaata ttattcgtaa tgtgctacca cgtcatgagc aaggtggtgt gtttgctgca      420

gagggttacg cacgggctac tgggttccct ggtgtttgca ttgctacctc tggtcccgga      480

gctacaaatc ttgttagtgg tcttgcggat gctttgttag atagtattcc gattgttgct      540

attacaggtc aagtgccaag gaggatgatt ggtactgatg cgttccagga aacgcctatt      600

gttgaggtaa cgagatctat tacgaagcat aattatcttg ttatggatgt agaagatatt      660

cctagggttg ttcgtgaagc attttttctt gcgaaatcgg gacggcctgg cccagttttg      720

attgatgtac ctaaggatat tcagcaacaa ttggtgatac ctaattggga tcagccaatg      780

aggttgcctg gttacatgtc taggttacct aaattgccta atgaaatgct tttggaacaa      840

attgttaggc tgatttccga gtcgaagaag cctgttttgt atgtgggtgg tgggtgttcg      900

caatcaagtg aggagctgag acgatttgtg gagcttacag gtattcctgt agcgagtact      960

ttgatgggtc ttggagcttt tccaactggg gatgagcttt cacttcaaat gttgggtatg     1020

catggaactg tgtatgctaa ttatgctgtg gatagtagtg atttgttgct tgcatttggg     1080

gtgaggtttg atgatcgagt tactggtaaa ttggaagctt ttgctagtcg agcgaaaatt     1140

gtccacattg atattgattc ggcagagatt ggaaaaaaca agcaacctca tgtttccatt     1200

tgtgcagata tcaagttggc attacagggt ttgaattcca tattggaggg taaagaaggt     1260

aagatgaagt tagatttttc tgcctggagg caggagttaa cggagcagaa gatgaagtac     1320

ccactgaatt ttaagacttt tggtgatgcc atccctccac aatatgctat tcaggttctt     1380

gatgagttaa ctaacggaaa tgccattatt agtactggtg tggggcaaca ccagatgtgg     1440

gctgcccaat actataagta caaaaagcca cgccaatggt tgacatctgg tggattagga     1500

gcaatgggat ttggtttgcc tgctgctata ggtgcggctg ttgggagacc gggtgagatt     1560

gtggttgaca ttgacggtga tgggagtttt atcatgaatg tgcaagagtt agcaacaatt     1620

aaggtggaga atctcccagt taagattatg ttgctgaata atcaacactt gggaatggtg     1680

gttcaatggg aggatcgatt ctataaagct aacagagcac acacttactt gggtgaccct     1740

tctaacgagg aagagatctt ccctaatatg ttgaaatttg cagaggcttg tggcgtacct     1800

gctgcaagag tgtcacacag ggatgatctt agagctgcca ttcaaaagat gttagacact     1860

cctgggccat acttgttgga tgtgattgta cctcatcagg agcacgttct acctatgatt     1920

cccagcggtg gtgctttcaa agatgtgatc acggagggcg atgggagatg ttcctattga     1980


<210>  2
<211>  1974
<212>  DNA
<213>  Solanum lycopersicon

<400>  2
atggcggctg catctccatc tccttgtttt tccaaaaccc tacctccatc ttcatcaaaa       60

tcttccaccc ttcttcccaa atctaccttt actttccaca atcaccctaa aaaagcatca      120

ccccttcacc ttacacacac ccaacatcat agccgtttca ctgtttcaaa tgtcatccta      180

tcaaccacga cgcatgacga cgtttctgaa cccgaaatct ttgtttcccg tttcgcccct      240

gacgaaccca gaaagggttg tgatgttctt gtggaggcac ttgaaaggga aggggttaag      300

gatgtgtttg catacccagg aggtgcttcc atggagattc atcaggcttt gacacgttca      360

aatattattc gtaatgtgct gccacgtcat gaacagggtg gtgtgtttgc tgcagagggt      420

tacgcacggg ctactgggtt ccctggtgtt tgtattgcta catctggtcc gggagctacg      480

aatcttgtta gcggtcttgc tgatgctttg ttggatagta tcccgattgt tgctattacc      540

ggtcaagtgc cgaggaggat gattggtact gatgcgtttc aggaaactcc tattgttgag      600

gtaacgagat ccattacgaa gcataattat cttgttatgg atgtagagga tattcctagg      660

gttgttcgtg aagcgttttt tctagcgaaa tcaggacggc ctggacctgt tttgattgat      720

gttcctaagg atattcagca acaattggtg atacctaatt gggatcagcc aatgaggttg      780

cctggttaca tgtctaggtt gcctaaatta cctaatgaga tgcttttgga acaaattgtt      840

aggctgattt cagagtcaaa gaagcctgtt ttgtatgtgg ggggtgggtg ttcacagtcg      900

agtgaggagc tgagacgctt tgtggagctt acgggtattc ctgtggcgag tactttgatg      960

ggtcttggag cttttccaag tggggatgag ctttctcttc aaatgttggg tatgcatggg     1020

actgtgtatg ctaattatgc ggtggatagt agtgatttgt tgcttgcatt tggggtgagg     1080

tttgatgatc gagttactgg taaattggaa gcttttgcta gccgagctaa gattgtccat     1140

attgatattg attcggctga gattggaaag aacaagcaac ctcatgtttc catctgtgca     1200

gatatcaagt tggcattaca gggtttgaat tccatattcg agagtaaaaa aggtaagctg     1260

aagttggact tttctgcttg gaggcaggag ttaacggagc agaaggtgaa gtacccattg     1320

aattttaaga ctttcggtga agccatccct ccccaatatg ctattcaggt tcttgatgag     1380

ttaactaacg gaaatgccat cattagtact ggtgtggggc aacaccaaat gtgggctgcc     1440

caacactaca agtacaaaaa gccacgccaa tggcttacat ctggtggatt aggagcaatg     1500

ggatttggtt tgcctgctgc tataggtgcg gctgttggaa gaccgggtga gattgtggtt     1560

gatattgatg gtgatgggag ttttatcatg aatgtgcagg agttggcaac aattaaggtg     1620

gagaatctcc cagttaagat tatgttgctg aataatcaac acttgggaat ggtggttcag     1680

tgggaggatc gattctataa ggctaacaga gcacacactt acttgggtaa tcctgctaat     1740

gaggaagaga tcttccctaa tatgctgaaa tttgcagagg cttgtggcgt acctgctgca     1800

agagtgtcac acagggatga tcttagagct gccattcaaa agatgttaga cactcctggg     1860

ccatacttgt tggatgtgat tgtacctcat caggagcatg ttctaccgat gattcccagt     1920

ggcggtgctt tcaaagatgt gattacggag ggtgatggga gacgttccta ttga           1974


<210>  3
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C22

<400>  3
ggtcagtgcc gaggaggatt gatt                                              24


<210>  4
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C17

<400>  4
ggtcaaagtg ccaggaggat gatt                                              24


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C14

<400>  5
ggtcaagtgc aaggaggatt gatt                                              24


<210>  6
<211>  1974
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS2_C22

<400>  6
atggcggctg catctccatc tccttgtttt tccaaaaccc tacctccatc ttcatcaaaa       60

tcttccaccc ttcttcccaa atctaccttt actttccaca atcaccctaa aaaagcatca      120

ccccttcacc ttacacacac ccaacatcat agccgtttca ctgtttcaaa tgtcatccta      180

tcaaccacga cgcatgacga cgtttctgaa cccgaaatct ttgtttcccg tttcgcccct      240

gacgaaccca gaaagggttg tgatgttctt gtggaggcac ttgaaaggga aggggttaag      300

gatgtgtttg catacccagg aggtgcttcc atggagattc atcaggcttt gacacgttca      360

aatattattc gtaatgtgct gccacgtcat gaacagggtg gtgtgtttgc tgcagagggt      420

tacgcacggg ctactgggtt ccctggtgtt tgtattgcta catctggtcc gggagctacg      480

aatcttgtta gcggtcttgc tgatgctttg ttggatagta tcccgattgt tgctattacc      540

ggtcagtgcc gaggaggatt gattggtact gatgcgtttc aggaaactcc tattgttgag      600

gtaacgagat ccattacgaa gcataattat cttgttatgg atgtagagga tattcctagg      660

gttgttcgtg aagcgttttt tctagcgaaa tcaggacggc ctggacctgt tttgattgat      720

gttcctaagg atattcagca acaattggtg atacctaatt gggatcagcc aatgaggttg      780

cctggttaca tgtctaggtt gcctaaatta cctaatgaga tgcttttgga acaaattgtt      840

aggctgattt cagagtcaaa gaagcctgtt ttgtatgtgg ggggtgggtg ttcacagtcg      900

agtgaggagc tgagacgctt tgtggagctt acgggtattc ctgtggcgag tactttgatg      960

ggtcttggag cttttccaag tggggatgag ctttctcttc aaatgttggg tatgcatggg     1020

actgtgtatg ctaattatgc ggtggatagt agtgatttgt tgcttgcatt tggggtgagg     1080

tttgatgatc gagttactgg taaattggaa gcttttgcta gccgagctaa gattgtccat     1140

attgatattg attcggctga gattggaaag aacaagcaac ctcatgtttc catctgtgca     1200

gatatcaagt tggcattaca gggtttgaat tccatattcg agagtaaaaa aggtaagctg     1260

aagttggact tttctgcttg gaggcaggag ttaacggagc agaaggtgaa gtacccattg     1320

aattttaaga ctttcggtga agccatccct ccccaatatg ctattcaggt tcttgatgag     1380

ttaactaacg gaaatgccat cattagtact ggtgtggggc aacaccaaat gtgggctgcc     1440

caacactaca agtacaaaaa gccacgccaa tggcttacat ctggtggatt aggagcaatg     1500

ggatttggtt tgcctgctgc tataggtgcg gctgttggaa gaccgggtga gattgtggtt     1560

gatattgatg gtgatgggag ttttatcatg aatgtgcagg agttggcaac aattaaggtg     1620

gagaatctcc cagttaagat tatgttgctg aataatcaac acttgggaat ggtggttcag     1680

tgggaggatc gattctataa ggctaacaga gcacacactt acttgggtaa tcctgctaat     1740

gaggaagaga tcttccctaa tatgctgaaa tttgcagagg cttgtggcgt acctgctgca     1800

agagtgtcac acagggatga tcttagagct gccattcaaa agatgttaga cactcctggg     1860

ccatacttgt tggatgtgat tgtacctcat caggagcatg ttctaccgat gattcccagt     1920

ggcggtgctt tcaaagatgt gattacggag ggtgatggga gacgttccta ttga           1974


<210>  7
<211>  1974
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS2_C17

<400>  7
atggcggctg catctccatc tccttgtttt tccaaaaccc tacctccatc ttcatcaaaa       60

tcttccaccc ttcttcccaa atctaccttt actttccaca atcaccctaa aaaagcatca      120

ccccttcacc ttacacacac ccaacatcat agccgtttca ctgtttcaaa tgtcatccta      180

tcaaccacga cgcatgacga cgtttctgaa cccgaaatct ttgtttcccg tttcgcccct      240

gacgaaccca gaaagggttg tgatgttctt gtggaggcac ttgaaaggga aggggttaag      300

gatgtgtttg catacccagg aggtgcttcc atggagattc atcaggcttt gacacgttca      360

aatattattc gtaatgtgct gccacgtcat gaacagggtg gtgtgtttgc tgcagagggt      420

tacgcacggg ctactgggtt ccctggtgtt tgtattgcta catctggtcc gggagctacg      480

aatcttgtta gcggtcttgc tgatgctttg ttggatagta tcccgattgt tgctattacc      540

ggtcaaagtg ccaggaggat gattggtact gatgcgtttc aggaaactcc tattgttgag      600

gtaacgagat ccattacgaa gcataattat cttgttatgg atgtagagga tattcctagg      660

gttgttcgtg aagcgttttt tctagcgaaa tcaggacggc ctggacctgt tttgattgat      720

gttcctaagg atattcagca acaattggtg atacctaatt gggatcagcc aatgaggttg      780

cctggttaca tgtctaggtt gcctaaatta cctaatgaga tgcttttgga acaaattgtt      840

aggctgattt cagagtcaaa gaagcctgtt ttgtatgtgg ggggtgggtg ttcacagtcg      900

agtgaggagc tgagacgctt tgtggagctt acgggtattc ctgtggcgag tactttgatg      960

ggtcttggag cttttccaag tggggatgag ctttctcttc aaatgttggg tatgcatggg     1020

actgtgtatg ctaattatgc ggtggatagt agtgatttgt tgcttgcatt tggggtgagg     1080

tttgatgatc gagttactgg taaattggaa gcttttgcta gccgagctaa gattgtccat     1140

attgatattg attcggctga gattggaaag aacaagcaac ctcatgtttc catctgtgca     1200

gatatcaagt tggcattaca gggtttgaat tccatattcg agagtaaaaa aggtaagctg     1260

aagttggact tttctgcttg gaggcaggag ttaacggagc agaaggtgaa gtacccattg     1320

aattttaaga ctttcggtga agccatccct ccccaatatg ctattcaggt tcttgatgag     1380

ttaactaacg gaaatgccat cattagtact ggtgtggggc aacaccaaat gtgggctgcc     1440

caacactaca agtacaaaaa gccacgccaa tggcttacat ctggtggatt aggagcaatg     1500

ggatttggtt tgcctgctgc tataggtgcg gctgttggaa gaccgggtga gattgtggtt     1560

gatattgatg gtgatgggag ttttatcatg aatgtgcagg agttggcaac aattaaggtg     1620

gagaatctcc cagttaagat tatgttgctg aataatcaac acttgggaat ggtggttcag     1680

tgggaggatc gattctataa ggctaacaga gcacacactt acttgggtaa tcctgctaat     1740

gaggaagaga tcttccctaa tatgctgaaa tttgcagagg cttgtggcgt acctgctgca     1800

agagtgtcac acagggatga tcttagagct gccattcaaa agatgttaga cactcctggg     1860

ccatacttgt tggatgtgat tgtacctcat caggagcatg ttctaccgat gattcccagt     1920

ggcggtgctt tcaaagatgt gattacggag ggtgatggga gacgttccta ttga           1974


<210>  8
<211>  1980
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS1_C14

<400>  8
atggcggctg ctgcctcacc atctccatgt ttctccaaaa ccctacctcc atcttcctcc       60

aaatcttcca ccattctacc tagatctacc ttctctttcc acaatcaccc acaaaaagcc      120

tcaccccttc atctcatcca cgctcaacat aatcgtcgtg gttttgccgt tgccaatgtc      180

gtcatatcca ctaccaccca taacgacgtt tctgaacctg aaacattcgt ttcccgtttc      240

gcccctgacg aacccagaaa gggttgtgat gttcttgtgg aggcacttga aagggaaggt      300

gttacggatg tatttgcata cccaggaggt gcttctatgg agattcatca agctttgaca      360

cgttcgaata ttattcgtaa tgtgctacca cgtcatgagc aaggtggtgt gtttgctgca      420

gagggttacg cacgggctac tgggttccct ggtgtttgca ttgctacctc tggtcccgga      480

gctacaaatc ttgttagtgg tcttgcggat gctttgttag atagtattcc gattgttgct      540

attacaggtc aagtgcaagg aggattgatt ggtactgatg cgttccagga aacgcctatt      600

gttgaggtaa cgagatctat tacgaagcat aattatcttg ttatggatgt agaagatatt      660

cctagggttg ttcgtgaagc attttttctt gcgaaatcgg gacggcctgg cccagttttg      720

attgatgtac ctaaggatat tcagcaacaa ttggtgatac ctaattggga tcagccaatg      780

aggttgcctg gttacatgtc taggttacct aaattgccta atgaaatgct tttggaacaa      840

attgttaggc tgatttccga gtcgaagaag cctgttttgt atgtgggtgg tgggtgttcg      900

caatcaagtg aggagctgag acgatttgtg gagcttacag gtattcctgt agcgagtact      960

ttgatgggtc ttggagcttt tccaactggg gatgagcttt cacttcaaat gttgggtatg     1020

catggaactg tgtatgctaa ttatgctgtg gatagtagtg atttgttgct tgcatttggg     1080

gtgaggtttg atgatcgagt tactggtaaa ttggaagctt ttgctagtcg agcgaaaatt     1140

gtccacattg atattgattc ggcagagatt ggaaaaaaca agcaacctca tgtttccatt     1200

tgtgcagata tcaagttggc attacagggt ttgaattcca tattggaggg taaagaaggt     1260

aagatgaagt tagatttttc tgcctggagg caggagttaa cggagcagaa gatgaagtac     1320

ccactgaatt ttaagacttt tggtgatgcc atccctccac aatatgctat tcaggttctt     1380

gatgagttaa ctaacggaaa tgccattatt agtactggtg tggggcaaca ccagatgtgg     1440

gctgcccaat actataagta caaaaagcca cgccaatggt tgacatctgg tggattagga     1500

gcaatgggat ttggtttgcc tgctgctata ggtgcggctg ttgggagacc gggtgagatt     1560

gtggttgaca ttgacggtga tgggagtttt atcatgaatg tgcaagagtt agcaacaatt     1620

aaggtggaga atctcccagt taagattatg ttgctgaata atcaacactt gggaatggtg     1680

gttcaatggg aggatcgatt ctataaagct aacagagcac acacttactt gggtgaccct     1740

tctaacgagg aagagatctt ccctaatatg ttgaaatttg cagaggcttg tggcgtacct     1800

gctgcaagag tgtcacacag ggatgatctt agagctgcca ttcaaaagat gttagacact     1860

cctgggccat acttgttgga tgtgattgta cctcatcagg agcacgttct acctatgatt     1920

cccagcggtg gtgctttcaa agatgtgatc acggagggcg atgggagatg ttcctattga     1980


<210>  9
<211>  659
<212>  PRT
<213>  Solanum lycopersicon

<400>  9

Met Ala Ala Ala Ala Ser Pro Ser Pro Cys Phe Ser Lys Thr Leu Pro 
1               5                   10                  15      


Pro Ser Ser Ser Lys Ser Ser Thr Ile Leu Pro Arg Ser Thr Phe Ser 
            20                  25                  30          


Phe His Asn His Pro Gln Lys Ala Ser Pro Leu His Leu Ile His Ala 
        35                  40                  45              


Gln His Asn Arg Arg Gly Phe Ala Val Ala Asn Val Val Ile Ser Thr 
    50                  55                  60                  


Thr Thr His Asn Asp Val Ser Glu Pro Glu Thr Phe Val Ser Arg Phe 
65                  70                  75                  80  


Ala Pro Asp Glu Pro Arg Lys Gly Cys Asp Val Leu Val Glu Ala Leu 
                85                  90                  95      


Glu Arg Glu Gly Val Thr Asp Val Phe Ala Tyr Pro Gly Gly Ala Ser 
            100                 105                 110         


Met Glu Ile His Gln Ala Leu Thr Arg Ser Asn Ile Ile Arg Asn Val 
        115                 120                 125             


Leu Pro Arg His Glu Gln Gly Gly Val Phe Ala Ala Glu Gly Tyr Ala 
    130                 135                 140                 


Arg Ala Thr Gly Phe Pro Gly Val Cys Ile Ala Thr Ser Gly Pro Gly 
145                 150                 155                 160 


Ala Thr Asn Leu Val Ser Gly Leu Ala Asp Ala Leu Leu Asp Ser Ile 
                165                 170                 175     


Pro Ile Val Ala Ile Thr Gly Gln Val Pro Arg Arg Met Ile Gly Thr 
            180                 185                 190         


Asp Ala Phe Gln Glu Thr Pro Ile Val Glu Val Thr Arg Ser Ile Thr 
        195                 200                 205             


Lys His Asn Tyr Leu Val Met Asp Val Glu Asp Ile Pro Arg Val Val 
    210                 215                 220                 


Arg Glu Ala Phe Phe Leu Ala Lys Ser Gly Arg Pro Gly Pro Val Leu 
225                 230                 235                 240 


Ile Asp Val Pro Lys Asp Ile Gln Gln Gln Leu Val Ile Pro Asn Trp 
                245                 250                 255     


Asp Gln Pro Met Arg Leu Pro Gly Tyr Met Ser Arg Leu Pro Lys Leu 
            260                 265                 270         


Pro Asn Glu Met Leu Leu Glu Gln Ile Val Arg Leu Ile Ser Glu Ser 
        275                 280                 285             


Lys Lys Pro Val Leu Tyr Val Gly Gly Gly Cys Ser Gln Ser Ser Glu 
    290                 295                 300                 


Glu Leu Arg Arg Phe Val Glu Leu Thr Gly Ile Pro Val Ala Ser Thr 
305                 310                 315                 320 


Leu Met Gly Leu Gly Ala Phe Pro Thr Gly Asp Glu Leu Ser Leu Gln 
                325                 330                 335     


Met Leu Gly Met His Gly Thr Val Tyr Ala Asn Tyr Ala Val Asp Ser 
            340                 345                 350         


Ser Asp Leu Leu Leu Ala Phe Gly Val Arg Phe Asp Asp Arg Val Thr 
        355                 360                 365             


Gly Lys Leu Glu Ala Phe Ala Ser Arg Ala Lys Ile Val His Ile Asp 
    370                 375                 380                 


Ile Asp Ser Ala Glu Ile Gly Lys Asn Lys Gln Pro His Val Ser Ile 
385                 390                 395                 400 


Cys Ala Asp Ile Lys Leu Ala Leu Gln Gly Leu Asn Ser Ile Leu Glu 
                405                 410                 415     


Gly Lys Glu Gly Lys Met Lys Leu Asp Phe Ser Ala Trp Arg Gln Glu 
            420                 425                 430         


Leu Thr Glu Gln Lys Met Lys Tyr Pro Leu Asn Phe Lys Thr Phe Gly 
        435                 440                 445             


Asp Ala Ile Pro Pro Gln Tyr Ala Ile Gln Val Leu Asp Glu Leu Thr 
    450                 455                 460                 


Asn Gly Asn Ala Ile Ile Ser Thr Gly Val Gly Gln His Gln Met Trp 
465                 470                 475                 480 


Ala Ala Gln Tyr Tyr Lys Tyr Lys Lys Pro Arg Gln Trp Leu Thr Ser 
                485                 490                 495     


Gly Gly Leu Gly Ala Met Gly Phe Gly Leu Pro Ala Ala Ile Gly Ala 
            500                 505                 510         


Ala Val Gly Arg Pro Gly Glu Ile Val Val Asp Ile Asp Gly Asp Gly 
        515                 520                 525             


Ser Phe Ile Met Asn Val Gln Glu Leu Ala Thr Ile Lys Val Glu Asn 
    530                 535                 540                 


Leu Pro Val Lys Ile Met Leu Leu Asn Asn Gln His Leu Gly Met Val 
545                 550                 555                 560 


Val Gln Trp Glu Asp Arg Phe Tyr Lys Ala Asn Arg Ala His Thr Tyr 
                565                 570                 575     


Leu Gly Asp Pro Ser Asn Glu Glu Glu Ile Phe Pro Asn Met Leu Lys 
            580                 585                 590         


Phe Ala Glu Ala Cys Gly Val Pro Ala Ala Arg Val Ser His Arg Asp 
        595                 600                 605             


Asp Leu Arg Ala Ala Ile Gln Lys Met Leu Asp Thr Pro Gly Pro Tyr 
    610                 615                 620                 


Leu Leu Asp Val Ile Val Pro His Gln Glu His Val Leu Pro Met Ile 
625                 630                 635                 640 


Pro Ser Gly Gly Ala Phe Lys Asp Val Ile Thr Glu Gly Asp Gly Arg 
                645                 650                 655     


Cys Ser Tyr 
            


<210>  10
<211>  657
<212>  PRT
<213>  Solanum lycopersicon

<400>  10

Met Ala Ala Ala Ser Pro Ser Pro Cys Phe Ser Lys Thr Leu Pro Pro 
1               5                   10                  15      


Ser Ser Ser Lys Ser Ser Thr Leu Leu Pro Lys Ser Thr Phe Thr Phe 
            20                  25                  30          


His Asn His Pro Lys Lys Ala Ser Pro Leu His Leu Thr His Thr Gln 
        35                  40                  45              


His His Ser Arg Phe Thr Val Ser Asn Val Ile Leu Ser Thr Thr Thr 
    50                  55                  60                  


His Asp Asp Val Ser Glu Pro Glu Ile Phe Val Ser Arg Phe Ala Pro 
65                  70                  75                  80  


Asp Glu Pro Arg Lys Gly Cys Asp Val Leu Val Glu Ala Leu Glu Arg 
                85                  90                  95      


Glu Gly Val Lys Asp Val Phe Ala Tyr Pro Gly Gly Ala Ser Met Glu 
            100                 105                 110         


Ile His Gln Ala Leu Thr Arg Ser Asn Ile Ile Arg Asn Val Leu Pro 
        115                 120                 125             


Arg His Glu Gln Gly Gly Val Phe Ala Ala Glu Gly Tyr Ala Arg Ala 
    130                 135                 140                 


Thr Gly Phe Pro Gly Val Cys Ile Ala Thr Ser Gly Pro Gly Ala Thr 
145                 150                 155                 160 


Asn Leu Val Ser Gly Leu Ala Asp Ala Leu Leu Asp Ser Ile Pro Ile 
                165                 170                 175     


Val Ala Ile Thr Gly Gln Val Pro Arg Arg Met Ile Gly Thr Asp Ala 
            180                 185                 190         


Phe Gln Glu Thr Pro Ile Val Glu Val Thr Arg Ser Ile Thr Lys His 
        195                 200                 205             


Asn Tyr Leu Val Met Asp Val Glu Asp Ile Pro Arg Val Val Arg Glu 
    210                 215                 220                 


Ala Phe Phe Leu Ala Lys Ser Gly Arg Pro Gly Pro Val Leu Ile Asp 
225                 230                 235                 240 


Val Pro Lys Asp Ile Gln Gln Gln Leu Val Ile Pro Asn Trp Asp Gln 
                245                 250                 255     


Pro Met Arg Leu Pro Gly Tyr Met Ser Arg Leu Pro Lys Leu Pro Asn 
            260                 265                 270         


Glu Met Leu Leu Glu Gln Ile Val Arg Leu Ile Ser Glu Ser Lys Lys 
        275                 280                 285             


Pro Val Leu Tyr Val Gly Gly Gly Cys Ser Gln Ser Ser Glu Glu Leu 
    290                 295                 300                 


Arg Arg Phe Val Glu Leu Thr Gly Ile Pro Val Ala Ser Thr Leu Met 
305                 310                 315                 320 


Gly Leu Gly Ala Phe Pro Ser Gly Asp Glu Leu Ser Leu Gln Met Leu 
                325                 330                 335     


Gly Met His Gly Thr Val Tyr Ala Asn Tyr Ala Val Asp Ser Ser Asp 
            340                 345                 350         


Leu Leu Leu Ala Phe Gly Val Arg Phe Asp Asp Arg Val Thr Gly Lys 
        355                 360                 365             


Leu Glu Ala Phe Ala Ser Arg Ala Lys Ile Val His Ile Asp Ile Asp 
    370                 375                 380                 


Ser Ala Glu Ile Gly Lys Asn Lys Gln Pro His Val Ser Ile Cys Ala 
385                 390                 395                 400 


Asp Ile Lys Leu Ala Leu Gln Gly Leu Asn Ser Ile Phe Glu Ser Lys 
                405                 410                 415     


Lys Gly Lys Leu Lys Leu Asp Phe Ser Ala Trp Arg Gln Glu Leu Thr 
            420                 425                 430         


Glu Gln Lys Val Lys Tyr Pro Leu Asn Phe Lys Thr Phe Gly Glu Ala 
        435                 440                 445             


Ile Pro Pro Gln Tyr Ala Ile Gln Val Leu Asp Glu Leu Thr Asn Gly 
    450                 455                 460                 


Asn Ala Ile Ile Ser Thr Gly Val Gly Gln His Gln Met Trp Ala Ala 
465                 470                 475                 480 


Gln His Tyr Lys Tyr Lys Lys Pro Arg Gln Trp Leu Thr Ser Gly Gly 
                485                 490                 495     


Leu Gly Ala Met Gly Phe Gly Leu Pro Ala Ala Ile Gly Ala Ala Val 
            500                 505                 510         


Gly Arg Pro Gly Glu Ile Val Val Asp Ile Asp Gly Asp Gly Ser Phe 
        515                 520                 525             


Ile Met Asn Val Gln Glu Leu Ala Thr Ile Lys Val Glu Asn Leu Pro 
    530                 535                 540                 


Val Lys Ile Met Leu Leu Asn Asn Gln His Leu Gly Met Val Val Gln 
545                 550                 555                 560 


Trp Glu Asp Arg Phe Tyr Lys Ala Asn Arg Ala His Thr Tyr Leu Gly 
                565                 570                 575     


Asn Pro Ala Asn Glu Glu Glu Ile Phe Pro Asn Met Leu Lys Phe Ala 
            580                 585                 590         


Glu Ala Cys Gly Val Pro Ala Ala Arg Val Ser His Arg Asp Asp Leu 
        595                 600                 605             


Arg Ala Ala Ile Gln Lys Met Leu Asp Thr Pro Gly Pro Tyr Leu Leu 
    610                 615                 620                 


Asp Val Ile Val Pro His Gln Glu His Val Leu Pro Met Ile Pro Ser 
625                 630                 635                 640 


Gly Gly Ala Phe Lys Asp Val Ile Thr Glu Gly Asp Gly Arg Arg Ser 
                645                 650                 655     


Tyr 
    


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C22

<400>  11

Gly Gln Cys Arg Gly Gly Leu Ile Gly Thr 
1               5                   10  


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C17

<400>  12

Gly Gln Ser Ala Arg Arg Met Ile Gly Thr 
1               5                   10  


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C14

<400>  13

Gly Gln Val Gln Gly Gly Leu Ile Gly Thr 
1               5                   10  


<210>  14
<211>  657
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALS2_C22

<400>  14

Met Ala Ala Ala Ser Pro Ser Pro Cys Phe Ser Lys Thr Leu Pro Pro 
1               5                   10                  15      


Ser Ser Ser Lys Ser Ser Thr Leu Leu Pro Lys Ser Thr Phe Thr Phe 
            20                  25                  30          


His Asn His Pro Lys Lys Ala Ser Pro Leu His Leu Thr His Thr Gln 
        35                  40                  45              


His His Ser Arg Phe Thr Val Ser Asn Val Ile Leu Ser Thr Thr Thr 
    50                  55                  60                  


His Asp Asp Val Ser Glu Pro Glu Ile Phe Val Ser Arg Phe Ala Pro 
65                  70                  75                  80  


Asp Glu Pro Arg Lys Gly Cys Asp Val Leu Val Glu Ala Leu Glu Arg 
                85                  90                  95      


Glu Gly Val Lys Asp Val Phe Ala Tyr Pro Gly Gly Ala Ser Met Glu 
            100                 105                 110         


Ile His Gln Ala Leu Thr Arg Ser Asn Ile Ile Arg Asn Val Leu Pro 
        115                 120                 125             


Arg His Glu Gln Gly Gly Val Phe Ala Ala Glu Gly Tyr Ala Arg Ala 
    130                 135                 140                 


Thr Gly Phe Pro Gly Val Cys Ile Ala Thr Ser Gly Pro Gly Ala Thr 
145                 150                 155                 160 


Asn Leu Val Ser Gly Leu Ala Asp Ala Leu Leu Asp Ser Ile Pro Ile 
                165                 170                 175     


Val Ala Ile Thr Gly Gln Cys Arg Gly Gly Leu Ile Gly Thr Asp Ala 
            180                 185                 190         


Phe Gln Glu Thr Pro Ile Val Glu Val Thr Arg Ser Ile Thr Lys His 
        195                 200                 205             


Asn Tyr Leu Val Met Asp Val Glu Asp Ile Pro Arg Val Val Arg Glu 
    210                 215                 220                 


Ala Phe Phe Leu Ala Lys Ser Gly Arg Pro Gly Pro Val Leu Ile Asp 
225                 230                 235                 240 


Val Pro Lys Asp Ile Gln Gln Gln Leu Val Ile Pro Asn Trp Asp Gln 
                245                 250                 255     


Pro Met Arg Leu Pro Gly Tyr Met Ser Arg Leu Pro Lys Leu Pro Asn 
            260                 265                 270         


Glu Met Leu Leu Glu Gln Ile Val Arg Leu Ile Ser Glu Ser Lys Lys 
        275                 280                 285             


Pro Val Leu Tyr Val Gly Gly Gly Cys Ser Gln Ser Ser Glu Glu Leu 
    290                 295                 300                 


Arg Arg Phe Val Glu Leu Thr Gly Ile Pro Val Ala Ser Thr Leu Met 
305                 310                 315                 320 


Gly Leu Gly Ala Phe Pro Ser Gly Asp Glu Leu Ser Leu Gln Met Leu 
                325                 330                 335     


Gly Met His Gly Thr Val Tyr Ala Asn Tyr Ala Val Asp Ser Ser Asp 
            340                 345                 350         


Leu Leu Leu Ala Phe Gly Val Arg Phe Asp Asp Arg Val Thr Gly Lys 
        355                 360                 365             


Leu Glu Ala Phe Ala Ser Arg Ala Lys Ile Val His Ile Asp Ile Asp 
    370                 375                 380                 


Ser Ala Glu Ile Gly Lys Asn Lys Gln Pro His Val Ser Ile Cys Ala 
385                 390                 395                 400 


Asp Ile Lys Leu Ala Leu Gln Gly Leu Asn Ser Ile Phe Glu Ser Lys 
                405                 410                 415     


Lys Gly Lys Leu Lys Leu Asp Phe Ser Ala Trp Arg Gln Glu Leu Thr 
            420                 425                 430         


Glu Gln Lys Val Lys Tyr Pro Leu Asn Phe Lys Thr Phe Gly Glu Ala 
        435                 440                 445             


Ile Pro Pro Gln Tyr Ala Ile Gln Val Leu Asp Glu Leu Thr Asn Gly 
    450                 455                 460                 


Asn Ala Ile Ile Ser Thr Gly Val Gly Gln His Gln Met Trp Ala Ala 
465                 470                 475                 480 


Gln His Tyr Lys Tyr Lys Lys Pro Arg Gln Trp Leu Thr Ser Gly Gly 
                485                 490                 495     


Leu Gly Ala Met Gly Phe Gly Leu Pro Ala Ala Ile Gly Ala Ala Val 
            500                 505                 510         


Gly Arg Pro Gly Glu Ile Val Val Asp Ile Asp Gly Asp Gly Ser Phe 
        515                 520                 525             


Ile Met Asn Val Gln Glu Leu Ala Thr Ile Lys Val Glu Asn Leu Pro 
    530                 535                 540                 


Val Lys Ile Met Leu Leu Asn Asn Gln His Leu Gly Met Val Val Gln 
545                 550                 555                 560 


Trp Glu Asp Arg Phe Tyr Lys Ala Asn Arg Ala His Thr Tyr Leu Gly 
                565                 570                 575     


Asn Pro Ala Asn Glu Glu Glu Ile Phe Pro Asn Met Leu Lys Phe Ala 
            580                 585                 590         


Glu Ala Cys Gly Val Pro Ala Ala Arg Val Ser His Arg Asp Asp Leu 
        595                 600                 605             


Arg Ala Ala Ile Gln Lys Met Leu Asp Thr Pro Gly Pro Tyr Leu Leu 
    610                 615                 620                 


Asp Val Ile Val Pro His Gln Glu His Val Leu Pro Met Ile Pro Ser 
625                 630                 635                 640 


Gly Gly Ala Phe Lys Asp Val Ile Thr Glu Gly Asp Gly Arg Arg Ser 
                645                 650                 655     


Tyr 
    


<210>  15
<211>  657
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALS2_C17

<400>  15

Met Ala Ala Ala Ser Pro Ser Pro Cys Phe Ser Lys Thr Leu Pro Pro 
1               5                   10                  15      


Ser Ser Ser Lys Ser Ser Thr Leu Leu Pro Lys Ser Thr Phe Thr Phe 
            20                  25                  30          


His Asn His Pro Lys Lys Ala Ser Pro Leu His Leu Thr His Thr Gln 
        35                  40                  45              


His His Ser Arg Phe Thr Val Ser Asn Val Ile Leu Ser Thr Thr Thr 
    50                  55                  60                  


His Asp Asp Val Ser Glu Pro Glu Ile Phe Val Ser Arg Phe Ala Pro 
65                  70                  75                  80  


Asp Glu Pro Arg Lys Gly Cys Asp Val Leu Val Glu Ala Leu Glu Arg 
                85                  90                  95      


Glu Gly Val Lys Asp Val Phe Ala Tyr Pro Gly Gly Ala Ser Met Glu 
            100                 105                 110         


Ile His Gln Ala Leu Thr Arg Ser Asn Ile Ile Arg Asn Val Leu Pro 
        115                 120                 125             


Arg His Glu Gln Gly Gly Val Phe Ala Ala Glu Gly Tyr Ala Arg Ala 
    130                 135                 140                 


Thr Gly Phe Pro Gly Val Cys Ile Ala Thr Ser Gly Pro Gly Ala Thr 
145                 150                 155                 160 


Asn Leu Val Ser Gly Leu Ala Asp Ala Leu Leu Asp Ser Ile Pro Ile 
                165                 170                 175     


Val Ala Ile Thr Gly Gln Ser Ala Arg Arg Met Ile Gly Thr Asp Ala 
            180                 185                 190         


Phe Gln Glu Thr Pro Ile Val Glu Val Thr Arg Ser Ile Thr Lys His 
        195                 200                 205             


Asn Tyr Leu Val Met Asp Val Glu Asp Ile Pro Arg Val Val Arg Glu 
    210                 215                 220                 


Ala Phe Phe Leu Ala Lys Ser Gly Arg Pro Gly Pro Val Leu Ile Asp 
225                 230                 235                 240 


Val Pro Lys Asp Ile Gln Gln Gln Leu Val Ile Pro Asn Trp Asp Gln 
                245                 250                 255     


Pro Met Arg Leu Pro Gly Tyr Met Ser Arg Leu Pro Lys Leu Pro Asn 
            260                 265                 270         


Glu Met Leu Leu Glu Gln Ile Val Arg Leu Ile Ser Glu Ser Lys Lys 
        275                 280                 285             


Pro Val Leu Tyr Val Gly Gly Gly Cys Ser Gln Ser Ser Glu Glu Leu 
    290                 295                 300                 


Arg Arg Phe Val Glu Leu Thr Gly Ile Pro Val Ala Ser Thr Leu Met 
305                 310                 315                 320 


Gly Leu Gly Ala Phe Pro Ser Gly Asp Glu Leu Ser Leu Gln Met Leu 
                325                 330                 335     


Gly Met His Gly Thr Val Tyr Ala Asn Tyr Ala Val Asp Ser Ser Asp 
            340                 345                 350         


Leu Leu Leu Ala Phe Gly Val Arg Phe Asp Asp Arg Val Thr Gly Lys 
        355                 360                 365             


Leu Glu Ala Phe Ala Ser Arg Ala Lys Ile Val His Ile Asp Ile Asp 
    370                 375                 380                 


Ser Ala Glu Ile Gly Lys Asn Lys Gln Pro His Val Ser Ile Cys Ala 
385                 390                 395                 400 


Asp Ile Lys Leu Ala Leu Gln Gly Leu Asn Ser Ile Phe Glu Ser Lys 
                405                 410                 415     


Lys Gly Lys Leu Lys Leu Asp Phe Ser Ala Trp Arg Gln Glu Leu Thr 
            420                 425                 430         


Glu Gln Lys Val Lys Tyr Pro Leu Asn Phe Lys Thr Phe Gly Glu Ala 
        435                 440                 445             


Ile Pro Pro Gln Tyr Ala Ile Gln Val Leu Asp Glu Leu Thr Asn Gly 
    450                 455                 460                 


Asn Ala Ile Ile Ser Thr Gly Val Gly Gln His Gln Met Trp Ala Ala 
465                 470                 475                 480 


Gln His Tyr Lys Tyr Lys Lys Pro Arg Gln Trp Leu Thr Ser Gly Gly 
                485                 490                 495     


Leu Gly Ala Met Gly Phe Gly Leu Pro Ala Ala Ile Gly Ala Ala Val 
            500                 505                 510         


Gly Arg Pro Gly Glu Ile Val Val Asp Ile Asp Gly Asp Gly Ser Phe 
        515                 520                 525             


Ile Met Asn Val Gln Glu Leu Ala Thr Ile Lys Val Glu Asn Leu Pro 
    530                 535                 540                 


Val Lys Ile Met Leu Leu Asn Asn Gln His Leu Gly Met Val Val Gln 
545                 550                 555                 560 


Trp Glu Asp Arg Phe Tyr Lys Ala Asn Arg Ala His Thr Tyr Leu Gly 
                565                 570                 575     


Asn Pro Ala Asn Glu Glu Glu Ile Phe Pro Asn Met Leu Lys Phe Ala 
            580                 585                 590         


Glu Ala Cys Gly Val Pro Ala Ala Arg Val Ser His Arg Asp Asp Leu 
        595                 600                 605             


Arg Ala Ala Ile Gln Lys Met Leu Asp Thr Pro Gly Pro Tyr Leu Leu 
    610                 615                 620                 


Asp Val Ile Val Pro His Gln Glu His Val Leu Pro Met Ile Pro Ser 
625                 630                 635                 640 


Gly Gly Ala Phe Lys Asp Val Ile Thr Glu Gly Asp Gly Arg Arg Ser 
                645                 650                 655     


Tyr 
    


<210>  16
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALS1_C14

<400>  16

Met Ala Ala Ala Ala Ser Pro Ser Pro Cys Phe Ser Lys Thr Leu Pro 
1               5                   10                  15      


Pro Ser Ser Ser Lys Ser Ser Thr Ile Leu Pro Arg Ser Thr Phe Ser 
            20                  25                  30          


Phe His Asn His Pro Gln Lys Ala Ser Pro Leu His Leu Ile His Ala 
        35                  40                  45              


Gln His Asn Arg Arg Gly Phe Ala Val Ala Asn Val Val Ile Ser Thr 
    50                  55                  60                  


Thr Thr His Asn Asp Val Ser Glu Pro Glu Thr Phe Val Ser Arg Phe 
65                  70                  75                  80  


Ala Pro Asp Glu Pro Arg Lys Gly Cys Asp Val Leu Val Glu Ala Leu 
                85                  90                  95      


Glu Arg Glu Gly Val Thr Asp Val Phe Ala Tyr Pro Gly Gly Ala Ser 
            100                 105                 110         


Met Glu Ile His Gln Ala Leu Thr Arg Ser Asn Ile Ile Arg Asn Val 
        115                 120                 125             


Leu Pro Arg His Glu Gln Gly Gly Val Phe Ala Ala Glu Gly Tyr Ala 
    130                 135                 140                 


Arg Ala Thr Gly Phe Pro Gly Val Cys Ile Ala Thr Ser Gly Pro Gly 
145                 150                 155                 160 


Ala Thr Asn Leu Val Ser Gly Leu Ala Asp Ala Leu Leu Asp Ser Ile 
                165                 170                 175     


Pro Ile Val Ala Ile Thr Gly Gln Val Gln Gly Gly Leu Ile Gly Thr 
            180                 185                 190         


Asp Ala Phe Gln Glu Thr Pro Ile Val Glu Val Thr Arg Ser Ile Thr 
        195                 200                 205             


Lys His Asn Tyr Leu Val Met Asp Val Glu Asp Ile Pro Arg Val Val 
    210                 215                 220                 


Arg Glu Ala Phe Phe Leu Ala Lys Ser Gly Arg Pro Gly Pro Val Leu 
225                 230                 235                 240 


Ile Asp Val Pro Lys Asp Ile Gln Gln Gln Leu Val Ile Pro Asn Trp 
                245                 250                 255     


Asp Gln Pro Met Arg Leu Pro Gly Tyr Met Ser Arg Leu Pro Lys Leu 
            260                 265                 270         


Pro Asn Glu Met Leu Leu Glu Gln Ile Val Arg Leu Ile Ser Glu Ser 
        275                 280                 285             


Lys Lys Pro Val Leu Tyr Val Gly Gly Gly Cys Ser Gln Ser Ser Glu 
    290                 295                 300                 


Glu Leu Arg Arg Phe Val Glu Leu Thr Gly Ile Pro Val Ala Ser Thr 
305                 310                 315                 320 


Leu Met Gly Leu Gly Ala Phe Pro Thr Gly Asp Glu Leu Ser Leu Gln 
                325                 330                 335     


Met Leu Gly Met His Gly Thr Val Tyr Ala Asn Tyr Ala Val Asp Ser 
            340                 345                 350         


Ser Asp Leu Leu Leu Ala Phe Gly Val Arg Phe Asp Asp Arg Val Thr 
        355                 360                 365             


Gly Lys Leu Glu Ala Phe Ala Ser Arg Ala Lys Ile Val His Ile Asp 
    370                 375                 380                 


Ile Asp Ser Ala Glu Ile Gly Lys Asn Lys Gln Pro His Val Ser Ile 
385                 390                 395                 400 


Cys Ala Asp Ile Lys Leu Ala Leu Gln Gly Leu Asn Ser Ile Leu Glu 
                405                 410                 415     


Gly Lys Glu Gly Lys Met Lys Leu Asp Phe Ser Ala Trp Arg Gln Glu 
            420                 425                 430         


Leu Thr Glu Gln Lys Met Lys Tyr Pro Leu Asn Phe Lys Thr Phe Gly 
        435                 440                 445             


Asp Ala Ile Pro Pro Gln Tyr Ala Ile Gln Val Leu Asp Glu Leu Thr 
    450                 455                 460                 


Asn Gly Asn Ala Ile Ile Ser Thr Gly Val Gly Gln His Gln Met Trp 
465                 470                 475                 480 


Ala Ala Gln Tyr Tyr Lys Tyr Lys Lys Pro Arg Gln Trp Leu Thr Ser 
                485                 490                 495     


Gly Gly Leu Gly Ala Met Gly Phe Gly Leu Pro Ala Ala Ile Gly Ala 
            500                 505                 510         


Ala Val Gly Arg Pro Gly Glu Ile Val Val Asp Ile Asp Gly Asp Gly 
        515                 520                 525             


Ser Phe Ile Met Asn Val Gln Glu Leu Ala Thr Ile Lys Val Glu Asn 
    530                 535                 540                 


Leu Pro Val Lys Ile Met Leu Leu Asn Asn Gln His Leu Gly Met Val 
545                 550                 555                 560 


Val Gln Trp Glu Asp Arg Phe Tyr Lys Ala Asn Arg Ala His Thr Tyr 
                565                 570                 575     


Leu Gly Asp Pro Ser Asn Glu Glu Glu Ile Phe Pro Asn Met Leu Lys 
            580                 585                 590         


Phe Ala Glu Ala Cys Gly Val Pro Ala Ala Arg Val Ser His Arg Asp 
        595                 600                 605             


Asp Leu Arg Ala Ala Ile Gln Lys Met Leu Asp Thr Pro Gly Pro Tyr 
    610                 615                 620                 


Leu Leu Asp Val Ile Val Pro His Gln Glu His Val Leu Pro Met Ile 
625                 630                 635                 640 


Pro Ser Gly Gly Ala Phe Lys Asp Val Ile Thr Glu Gly Asp Gly Arg 
                645                 650                 655     


Cys Ser Tyr 
            


<210>  17
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS1 WT part

<400>  17
ggtcaagtgc caaggaggat gatt                                              24


<210>  18
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS2 WT part

<400>  18
ggtcaagtgc cgaggaggat gatt                                              24


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALS WT1-2 part

<400>  19

Gly Gln Val Pro Arg Arg Met Ile Gly Thr 
1               5                   10  


<210>  20
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS1_WT part extended

<400>  20
gctattacag gtcaagtgcc aaggaggatg attggtact                              39


<210>  21
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS2_WT part extended

<400>  21
gctattaccg gtcaagtgcc gaggaggatg attggtact                              39


<210>  22
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALS 1-2 part extended

<400>  22

Ala Ile Thr Gly Gln Val Pro Arg Arg Met Ile Gly Thr 
1               5                   10              


<210>  23
<211>  5126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promotor/Cas9


<220>
<221>  promoter
<222>  (1)..(972)

<220>
<221>  misc_feature
<222>  (987)..(5126)
<223>  ORF

<400>  23
aaaaattacg gatatgaata taggcatatc cgtatccgaa ttatccgttt gacagctagc       60

aacgattgta caattgcttc tttaaaaaag gaagaaagaa agaaagaaaa gaatcaacat      120

cagcgttaac aaacggcccc gttacggccc aaacggtcat atagagtaac ggcgttaagc      180

gttgaaagac tcctatcgaa atacgtaacc gcaaacgtgt catagtcaga tcccctcttc      240

cttcaccgcc tcaaacacaa aaataatctt ctacagccta tatatacaac ccccccttct      300

atctctcctt tctcacaatt catcatcttt ctttctctac ccccaatttt aagaaatcct      360

ctcttctcct cttcattttc aaggtaaatc tctctctctc tctctctctc tgttattcct      420

tgttttaatt aggtatgtat tattgctagt ttgttaatct gcttatctta tgtatgcctt      480

atgtgaatat ctttatcttg ttcatctcat ccgtttagaa gctataaatt tgttgatttg      540

actgtgtatc tacacgtggt tatgtttata tctaatcaga tatgaatttc ttcatattgt      600

tgcgtttgtg tgtaccaatc cgaaatcgtt gatttttttc atttaatcgt gtagctaatt      660

gtacgtatac atatggatct acgtatcaat tgttcatctg tttgtgtttg tatgtataca      720

gatctgaaaa catcacttct ctcatctgat tgtgttgtta catacataga tatagatctg      780

ttatatcatt ttttttatta attgtgtata tatatatgtg catagatctg gattacatga      840

ttgtgattat ttacatgatt ttgttattta cgtatgtata tatgtagatc tggacttttt      900

ggagttgttg acttgattgt atttgtgtgt gtatatgtgt gttctgatct tgatatgtta      960

tgtatgtgca gcgaattcgg cgcgccatgg ataagaagta ctctatcgga ctcgatatcg     1020

gaactaactc tgtgggatgg gctgtgatca ccgatgagta caaggtgcca tctaagaagt     1080

tcaaggttct cggaaacacc gataggcact ctatcaagaa aaaccttatc ggtgctctcc     1140

tcttcgattc tggtgaaact gctgaggcta ccagactcaa gagaaccgct agaagaaggt     1200

acaccagaag aaagaacagg atctgctacc tccaagagat cttctctaac gagatggcta     1260

aagtggatga ttcattcttc cacaggctcg aagagtcatt cctcgtggaa gaagataaga     1320

agcacgagag gcaccctatc ttcggaaaca tcgttgatga ggtggcatac cacgagaagt     1380

accctactat ctaccacctc agaaagaagc tcgttgattc tactgataag gctgatctca     1440

ggctcatcta cctcgctctc gctcacatga tcaagttcag aggacacttc ctcatcgagg     1500

gtgatctcaa ccctgataac tctgatgtgg ataagttgtt catccagctc gtgcagacct     1560

acaaccagct tttcgaagag aaccctatca acgcttcagg tgtggatgct aaggctatcc     1620

tctctgctag gctctctaag tcaagaaggc ttgagaacct cattgctcag ctccctggtg     1680

agaagaagaa cggacttttc ggaaacttga tcgctctctc tctcggactc acccctaact     1740

tcaagtctaa cttcgatctc gctgaggatg caaagctcca gctctcaaag gatacctacg     1800

atgatgatct cgataacctc ctcgctcaga tcggagatca gtacgctgat ttgttcctcg     1860

ctgctaagaa cctctctgat gctatcctcc tcagtgatat cctcagagtg aacaccgaga     1920

tcaccaaggc tccactctca gcttctatga tcaagagata cgatgagcac caccaggatc     1980

tcacacttct caaggctctt gttagacagc agctcccaga gaagtacaaa gagattttct     2040

tcgatcagtc taagaacgga tacgctggtt acatcgatgg tggtgcatct caagaagagt     2100

tctacaagtt catcaagcct atcctcgaga agatggatgg aaccgaggaa ctcctcgtga     2160

agctcaatag agaggatctt ctcagaaagc agaggacctt cgataacgga tctatccctc     2220

atcagatcca cctcggagag ttgcacgcta tccttagaag gcaagaggat ttctacccat     2280

tcctcaagga taacagggaa aagattgaga agattctcac cttcagaatc ccttactacg     2340

tgggacctct cgctagagga aactcaagat tcgcttggat gaccagaaag tctgaggaaa     2400

ccatcacccc ttggaacttc gaagaggtgg tggataaggg tgctagtgct cagtctttca     2460

tcgagaggat gaccaacttc gataagaacc ttccaaacga gaaggtgctc cctaagcact     2520

ctttgctcta cgagtacttc accgtgtaca acgagttgac caaggttaag tacgtgaccg     2580

agggaatgag gaagcctgct tttttgtcag gtgagcaaaa gaaggctatc gttgatctct     2640

tgttcaagac caacagaaag gtgaccgtga agcagctcaa agaggattac ttcaagaaaa     2700

tcgagtgctt cgattcagtt gagatttctg gtgttgagga taggttcaac gcatctctcg     2760

gaacctacca cgatctcctc aagatcatta aggataagga tttcttggat aacgaggaaa     2820

acgaggatat cttggaggat atcgttctta ccctcaccct ctttgaagat agagagatga     2880

ttgaagaaag gctcaagacc tacgctcatc tcttcgatga taaggtgatg aagcagttga     2940

agagaagaag atacactggt tggggaaggc tctcaagaaa gctcattaac ggaatcaggg     3000

ataagcagtc tggaaagaca atccttgatt tcctcaagtc tgatggattc gctaacagaa     3060

acttcatgca gctcatccac gatgattctc tcacctttaa agaggatatc cagaaggctc     3120

aggtttcagg acagggtgat agtctccatg agcatatcgc taacctcgct ggatctcctg     3180

caatcaagaa gggaatcctc cagactgtga aggttgtgga tgagttggtg aaggtgatgg     3240

gaaggcataa gcctgagaac atcgtgatcg aaatggctag agagaaccag accactcaga     3300

agggacagaa gaactctagg gaaaggatga agaggatcga ggaaggtatc aaagagcttg     3360

gatctcagat cctcaaagag caccctgttg agaacactca gctccagaat gagaagctct     3420

acctctacta cctccagaac ggaagggata tgtatgtgga tcaagagttg gatatcaaca     3480

ggctctctga ttacgatgtt gatcatatcg tgccacagtc attcttgaag gatgattcta     3540

tcgataacaa ggtgctcacc aggtctgata agaacagggg taagagtgat aacgtgccaa     3600

gtgaagaggt tgtgaagaaa atgaagaact attggaggca gctcctcaac gctaagctca     3660

tcactcagag aaagttcgat aacttgacta aggctgagag gggaggactc tctgaattgg     3720

ataaggcagg attcatcaag aggcagcttg tggaaaccag gcagatcact aagcacgttg     3780

cacagatcct cgattctagg atgaacacca agtacgatga gaacgataag ttgatcaggg     3840

aagtgaaggt tatcaccctc aagtcaaagc tcgtgtctga tttcagaaag gatttccaat     3900

tctacaaggt gagggaaatc aacaactacc accacgctca cgatgcttac cttaacgctg     3960

ttgttggaac cgctctcatc aagaagtatc ctaagctcga gtcagagttc gtgtacggtg     4020

attacaaggt gtacgatgtg aggaagatga tcgctaagtc tgagcaagag atcggaaagg     4080

ctaccgctaa gtatttcttc tactctaaca tcatgaattt cttcaagacc gagattaccc     4140

tcgctaacgg tgagatcaga aagaggccac tcatcgagac aaacggtgaa acaggtgaga     4200

tcgtgtggga taagggaagg gatttcgcta ccgttagaaa ggtgctctct atgccacagg     4260

tgaacatcgt taagaaaacc gaggtgcaga ccggtggatt ctctaaagag tctatcctcc     4320

ctaagaggaa ctctgataag ctcattgcta ggaagaagga ttgggaccct aagaaatacg     4380

gtggtttcga ttctcctacc gtggcttact ctgttctcgt tgtggctaag gttgagaagg     4440

gaaagagtaa gaagctcaag tctgttaagg aacttctcgg aatcactatc atggaaaggt     4500

catctttcga gaagaaccca atcgatttcc tcgaggctaa gggatacaaa gaggttaaga     4560

aggatctcat catcaagctc ccaaagtact cactcttcga actcgagaac ggtagaaaga     4620

ggatgctcgc ttctgctggt gagcttcaaa agggaaacga gcttgctctc ccatctaagt     4680

acgttaactt tctttacctc gcttctcact acgagaagtt gaagggatct ccagaagata     4740

acgagcagaa gcaacttttc gttgagcagc acaagcacta cttggatgag atcatcgagc     4800

agatctctga gttctctaaa agggtgatcc tcgctgatgc aaacctcgat aaggtgttgt     4860

ctgcttacaa caagcacaga gataagccta tcagggaaca ggcagagaac atcatccatc     4920

tcttcaccct taccaacctc ggtgctcctg ctgctttcaa gtacttcgat acaaccatcg     4980

ataggaagag atacacctct accaaagaag tgctcgatgc taccctcatc catcagtcta     5040

tcactggact ctacgagact aggatcgatc tctcacagct cggtggtgat tcaagggctg     5100

atcctaagaa gaagaggaag gtttga                                          5126


<210>  24
<211>  1379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAS9

<400>  24

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Ser Arg  Ala Asp Pro Lys Lys  Lys Arg Lys Val 
    1370                 1375                 


<210>  25
<211>  221
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KG10177

<400>  25
ggagtgatca aaagtcccac atcgatcagg tgatatatag cagcttagtt tatataatga       60

tagagtcgac atagcgattg caagtgccga ggaggatgat gttttagagc tagaaatagc      120

aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt      180

tttctagacc cagctttctt gtacaaagtt ggcattacgc t                          221


<210>  26
<211>  221
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KG10190

<400>  26
ggagtgatca aaagtcccac atcgatcagg tgatatatag cagcttagtt tatataatga       60

tagagtcgac atagcgattg catcctcctc ggcacttgac gttttagagc tagaaatagc      120

aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt      180

tttctagacc cagctttctt gtacaaagtt ggcattacgc t                          221


<210>  27
<211>  221
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KG10191

<400>  27
ggagtgatca aaagtcccac atcgatcagg tgatatatag cagcttagtt tatataatga       60

tagagtcgac atagcgattg ttaccggtca agtgccgagg gttttagagc tagaaatagc      120

aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt      180

tttctagacc cagctttctt gtacaaagtt ggcattacgc t                          221


<210>  28
<211>  644
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KG10240

<400>  28
ggagtgatca aaagtcccac atcgatcagg tgatatatag cagcttagtt tatataatga       60

tagagtcgac atagcgattg aacaaagcac cagtggtcta gtggtagaat agtaccctgc      120

cacggtacag acccgggttc gattcccggc tggtgcacaa gtgccgagga ggatgatgtt      180

ttagagctag aaatagcaag ttaaaataag gctagtccgt tatcaacttg aaaaagtggc      240

accgagtcgg tgcaacaaag caccagtggt ctagtggtag aatagtaccc tgccacggta      300

cagacccggg ttcgattccc ggctggtgca catcctcctc ggcacttgac gttttagagc      360

tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt      420

cggtgcaaca aagcaccagt ggtctagtgg tagaatagta ccctgccacg gtacagaccc      480

gggttcgatt cccggctggt gcattaccgg tcaagtgccg agggttttag agctagaaat      540

agcaagttaa aataaggcta gtccgttatc aacttgaaaa agtggcaccg agtcggtgct      600

ttttttctag acccagcttt cttgtacaaa gttggcatta cgct                       644


<210>  29
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS2 fig3

<400>  29
attaccggtc aagtgccgag gaggatgatt gg                                     32


<210>  30
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS2 sgRNA1

<400>  30
attaccggtc aagtgccgag gaggattgat tgg                                    33


<210>  31
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS2 sgRNA1a

<400>  31
attaccggtc aagtgccggg atgattgg                                          28


<210>  32
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS2 sgRNA1b

<400>  32
attaccggtc aagtgccgag gatgattgg                                         29


<210>  33
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS2 sgRNA1c

<400>  33
attaccggtc aagtgccgag gagattgg                                          28


<210>  34
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS2 sgRNA2

<400>  34
attaccggtc aaagtgccga ggaggatgat tgg                                    33


<210>  35
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS2 sgRNA2a

<400>  35
attaccggtc agtgccgagg aggatgattg g                                      31


<210>  36
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS2 sgRNA2b

<400>  36
attaccggtc gtgccgagga ggatgattgg                                        30


<210>  37
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS2 sgRNA2c

<400>  37
attaccggtc atgccgagga ggatgattgg                                        30


<210>  38
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS2 sgRNA3

<400>  38
attaccggtc aagtgccagg aggatgattg g                                      31


<210>  39
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS2 sgRNA3a

<400>  39
attaccggtc aaggaggatg attgg                                             25


<210>  40
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS2 sgRNA3b

<400>  40
attaccggtc aagtgccgca ggaggatgat tgg                                    33


<210>  41
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS2 sgRNA3c

<400>  41
attaccggtc aagtgccgta ggaggatgat tgg                                    33


<210>  42
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS2 sg1+2+3

<400>  42
attaccggtc aagtgccggg atgattgg                                          28


<210>  43
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS2 sg1+2+3a

<400>  43
attaccggtc aagtgccagg aggatgattg g                                      31


<210>  44
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   ALS2 sg1+2+3b

<400>  44
attaccggtc aagtgccgag attgg                                             25


<210>  45
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS2 sg1+2+3c

<400>  45
attaccggtc gccgaggagg attgattgg                                         29


<210>  46
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS2 sg1+2+3d

<400>  46
attaccggtc aagtgccgta ggagggattg g                                      31


<210>  47
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS2 sg1+2+3e

<400>  47
attaccggtc aagtgccagg aggagattgg                                        30


<210>  48
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS2 sg1+2+3f

<400>  48
attaccggtc tgccgaggag gattgattgg                                        30


<210>  49
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS2 sg1+2+3g

<400>  49
attaccggtc agccgaggag gattgg                                            26


<210>  50
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS1 fig3

<400>  50
attacaggtc aagtgccaag gaggatgatt gg                                     32


<210>  51
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   ALS1 sgRNA1

<400>  51
attacaggtc aagtgccaag gaggatattg g                                      31


<210>  52
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS1 sgRNA1a

<400>  52
attacaggtc aagtgccaag gaggattgat tgg                                    33


<210>  53
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   ALS1 sgRNA1b

<400>  53
attacaggtc aagtgccaag gaggattgg                                         29


<210>  54
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   ALS1 sgRNA1c

<400>  54
attacaggtc aagtgccaag gagggattgg                                        30


<210>  55
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS1 sgRNA3

<400>  55
attacaggtc aagtgccaaa ggaggatgat tgg                                    33


<210>  56
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS1 sgRNA3a

<400>  56
attacaggtc aaggaggatg attgg                                             25


<210>  57
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS1 sgRNA3b

<400>  57
attacaggtc aagtgccagg aggatgattg g                                      31


<210>  58
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   ALS1 sgRNA3c

<400>  58
attacaggtc aagtaggagg atgattgg                                          28


<210>  59
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   ALS1 sg1+2+3

<400>  59
attacaggtc aagtgccagg aggatgattg g                                      31


<210>  60
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS1 sg1+2+3a

<400>  60
attacaggtc aagtgccaag gatgattgg                                         29


<210>  61
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   ALS1 sg1+2+3b

<400>  61
attacaggtc aagtgccaag gagattgg                                          28


<210>  62
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS1 sg1+2+3c

<400>  62
attacaggtc aagtgccaag gaggattgat tgg                                    33


<210>  63
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   ALS1 sg1+2+3d

<400>  63
attacaggtc aagtgccaaa ggaggattga ttgg                                   34


<210>  64
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS1 sg1+2+3e

<400>  64
attacaggtc aagtgccagg aggattgatt gg                                     32


<210>  65
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   ALS1 sg1+2+3f

<400>  65
attacaggtc aagtgccagg agggattgg                                         29


<210>  66
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALS1 sg1+2+3g

<400>  66
attacaggtc aagtaggagg attgattgg                                         29


<210>  67
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer ALS1 Fw

<400>  67
tggcgctcat cacttctt                                                     18


<210>  68
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer ALS1 Rev

<400>  68
cgttacctca acaataggcg tttcct                                            26


<210>  69
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer ALS2 Fw

<400>  69
cacctcattt tcatggccct                                                   20


<210>  70
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer ALS2 Rev

<400>  70
agccttcacg aacaacccta                                                   20


<210>  71
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  71

Gly Gln Cys Arg Gly Gly Leu Ile Gly Thr 
1               5                   10  


<210>  72
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  72

Gly Gln Ser Ala Arg Arg Met Ile Gly Thr 
1               5                   10  


<210>  73
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  73

Gly Gln Val Pro Gly Gly Leu Met Ile Gly Thr 
1               5                   10      


<210>  74
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  74

Gly Arg Arg Gly Gly Leu Ile Gly Thr 
1               5                   


<210>  75
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  75

Gly Gln Val Gln Gly Gly Leu Ile Gly Thr 
1               5                   10  


