﻿               SEQUENCE LISTING

<110> AbbVie Deutschland GmbH & Co. KG

<120> Albumin-modified nanoparticle carrying a targeting ligand

<130> ABV12396WOO1

<160> 19

<170> BiSSAP 1.3.6

<210> 1
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> LDL receptor-binding domain of ApoE4

<400> 1
Tyr Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Leu Arg Lys Arg 
1               5                   10                  15      
Leu Leu Arg Asp Ala Asp Asp Leu Tyr 
            20                  25  

<210> 2
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Acetylcholine receptor-binding domain of RVG (RVG29)

<400> 2
Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Pro Gly Thr Pro Cys Asp 
1               5                   10                  15      
Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Asn Gly 
            20                  25                  

<210> 3
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> Angiopep-2

<400> 3
Thr Phe Phe Tyr Gly Gly Ser Arg Gly Lys Arg Asn Asn Phe Lys Thr 
1               5                   10                  15      
Glu Glu Tyr 
            

<210> 4
<211> 39
<212> PRT
<213> Artificial Sequence


<220> 
<223> ApoB (3371–3409)

<400> 4
Ser Ser Val Ile Asp Ala Leu Gln Tyr Lys Leu Glu Gly Thr Thr Arg 
1               5                   10                  15      
Leu Thr Arg Lys Arg Gly Leu Lys Leu Ala Thr Ala Leu Ser Leu Ser 
            20                  25                  30          
Asn Lys Phe Val Glu Gly Ser 
        35                  

<210> 5
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> ApoE (159–167)2

<400> 5
Leu Arg Lys Leu Arg Lys Arg Leu Leu Leu Arg Lys Leu Arg Lys Arg 
1               5                   10                  15      
Leu Leu 
        

<210> 6
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<221> MOD_RES
<222> 1
<223> ACETYLATION

<220> 
<221> DISULFID
<222> join(1,8)

<220> 
<223> Peptide-22

<220> 
<221> MOD_RES
<222> 8
<223> AMIDATION

<400> 6
Cys Met Pro Arg Leu Arg Gly Cys 
1               5               

<210> 7
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> transferrin receptor binding-peptide THR

<220> 
<221> MOD_RES
<222> 12
<223> AMIDATION

<400> 7
Thr His Arg Pro Pro Met Trp Ser Pro Val Trp Pro 
1               5                   10          

<210> 8
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<221> DISULFID
<222> join(1,9)

<220> 
<223> CRT

<400> 8
Cys Arg Thr Ile Gly Pro Ser Val Cys 
1               5                   

<210> 9
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> Leptin30

<400> 9
Tyr Gln Gln Ile Leu Thr Ser Met Pro Ser Arg Asn Val Ile Gln Ile 
1               5                   10                  15      
Ser Asn Asp Leu Glu Asn Leu Arg Asp Leu Leu His Val Leu 
            20                  25                  30  

<210> 10
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<221> DISULFID
<222> join(1,10)

<220> 
<223> Apamin

<220> 
<221> DISULFID
<222> join(2,14)

<220> 
<221> MOD_RES
<222> 17
<223> AMIDATION

<400> 10
Cys Cys Lys Ala Pro Glu Thr Ala Leu Cys Ala Arg Arg Cys Gln Gln 
1               5                   10                  15      
His 
    

<210> 11
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<221> MOD_RES
<222> 1
<223> N- and C-terminus linked by diaminopropyl

<220> 
<223> MiniAp-4

<400> 11
Lys Ala Pro Glu Thr Ala Leu Asp 
1               5               

<210> 12
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> G23

<400> 12
His Leu Asn Ile Leu Ser Thr Leu Trp Lys Tyr Arg Cys 
1               5                   10              

<210> 13
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> G7

<220> 
<221> MOD_RES
<222> 3
<223> Thr is D amino acid

<220> 
<221> CARBOHYD
<222> 7
<223> O-linked beta-Glc

<220> 
<221> MOD_RES
<222> 7
<223> AMIDATION

<400> 13
Gly Phe Thr Gly Phe Leu Ser 
1               5           

<210> 14
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> TGN

<400> 14
Thr Gly Asn Tyr Lys Ala Leu His Pro His Asn Gly 
1               5                   10          

<210> 15
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> TAT (47–57)

<220> 
<221> MOD_RES
<222> 11
<223> AMIDATION

<400> 15
Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      

<210> 16
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> SynB1

<400> 16
Arg Gly Gly Arg Leu Ser Tyr Ser Arg Arg Arg Phe Ser Thr Ser Thr 
1               5                   10                  15      
Gly Arg 
        

<210> 17
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<221> MOD_RES
<222> 1..4
<223> phenylated

<220> 
<223> PhPro

<220> 
<221> MOD_RES
<222> 4
<223> AMIDATION

<400> 17
Pro Pro Pro Pro 
1               

<210> 18
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> EPRNEEK

<400> 18
Glu Pro Arg Asn Glu Glu Lys 
1               5           

<210> 19
<211> 36
<212> PRT
<213> Leiurus quinquestriatus


<220> 
<223> chlorotoxin

<220> 
<221> DISULFID
<222> join(2,19)

<220> 
<221> DISULFID
<222> join(5,28)

<220> 
<221> DISULFID
<222> join(15,33)

<220> 
<221> DISULFID
<222> join(20,35)

<220> 
<221> MOD_RES
<222> 36
<223> AMIDATION

<400> 19
Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Met Ala Arg Lys Cys 
1               5                   10                  15      
Asp Asp Cys Cys Gly Gly Lys Gly Arg Gly Lys Cys Tyr Gly Pro Gln 
            20                  25                  30          
Cys Leu Cys Arg 
        35      

