                         SEQUENCE LISTING

<110>  Novozymes A/S
       Maiyuran, Suchindra
       Shasky, Jeffrey
       Lehmbeck, Jan
 
<120>  Methods For Improving Genome Editing In Fungi

<130>  14259-WO-PCT

<150>  US 62/553,374
<151>  2017-09-01

<160>  115   

<170>  PatentIn version 3.5

<210>  1
<211>  6889
<212>  DNA
<213>  Trichoderma reesei

<400>  1
atgctggatt caacgtctgc catggaaagc acgacgatct accaatccga tgccgagatt       60

cgctcagttc gggttatcgt ctttggagat cagagtagct gtagcctttc gaagctgcag      120

cagctgctgt tgaagaagga cagcccctac ttgacatctt tcatcgaccg ggtcaatcac      180

accttgagac atgaggtggc tcggcttacg actgcagagc gacaatcatt tccagccttc      240

tgtagcatcc aaaaccttgt ctctcgcgtc ttgaaaaccg acaaacacac cgagaatgcg      300

gcggtagaga gtaccttggc aactgtctat cagttgtgct gtttcttcag gtgagaatgc      360

caatggcagt gccggtgtag tgagaagcta acaagaacgc agtcacttcg gtaacggcca      420

agaaacgtac ccaacagggc cagatacgca cgtctccgga ttgtgcattg gagcattagc      480

cgcggcagca gtcagttcct cgcggtcact tggcgaactg gtggaggcgg gaatcgatgc      540

agttcgtgtg tcactgagag taggtctgtt ggttgccaga actgccgctt tgttcggcca      600

gccacaatca accggcacct catcttggtc atatgttgtc cccgaatcac agatcccact      660

ggcttttgcg gaaaaggcca tctcgtcgta taatgatgaa tctgtgagtt gctatgacta      720

tgccttctct agatatgaaa atggctaata gaacagaaca tcccccctct gtcttcgcca      780

tacatcagtg cgaagggtca gaattcctgg acactcagcg gtccaccagc agttgtgcag      840

cacttcctac agtcttcgca gttttcggga aagctgaaga ttacgccgat cgctgtacat      900

gctccgtatc atgcgtcgca catcttctcc gtccgagaca ttgaacaact gcttcgggat      960

gttggatcgg tcagcggcct cacgagcaaa ctgcccttca tcccaagttc taccgagcga     1020

agccctcttc aaggggctca gttccaggat ttactacaac acgtcctcga gggtattctc     1080

atccagccgc tagacttgag agaggctgcc gagaacatac aaaaggtgtt tgaggccgca     1140

ggccccactg gccaatgcgc gttgcttcca gtgtcaacaa gcgtttgctc aagtctcaag     1200

gtctcatttc cgccaccgct ctcgaggcgc gtcgctgtcc tcgacagcat cacggaaggc     1260

attgcggtaa gcacagtgtc gaatcctccg ggcaccggta gaccagccga ctccaagatt     1320

gccattgtgg gcatgtccgg aagattcccc gaatctgcag atgttgaagc gttctgggac     1380

cttctttacc aagggcttga cgtccatcga cgagtgccag cagacagata caacgcagag     1440

ctatactatg acccgactgg caagcggaag aatacaagca agatcatgca tggttgctgg     1500

attaatgagc ctggactgtt tgacgcaaag ttcttcaaca tctctccaaa agaagctgag     1560

caatccgatc ctggccagcg cctggccctg gcgaccgcgt atgaggcgct tgagatggca     1620

ggcatcgttg ctgatagaac gccgtcaaca caacgtgacc gtgtgggcgt cttttacggc     1680

atgacgagtg acgactacag agaagtcagt tgtggccaga acgtggacac atatttcatc     1740

ccaggtaagt accaaccccg aactacgaat tgtcgatagg ccagtgtatc aaatgcttac     1800

ttggctcagg tggaaatcga gcctttacac caggcaagat caattatttc ttcaaatact     1860

gcggcccatc ggtcagtgtt gacactgcat ggtaagttga acattccaga agcccccata     1920

caaaagcctc tggctctgac tctgcatgat tagctcttca agtcttgcgg ccattcactt     1980

agcttgcaac tccatctggc gaaatgaatg tgatacagcc gttgcaggtg gtaccaatgt     2040

catgtcgaac cctgacagtt ttgcgggatt ggatcgcgga cattttctgt caagaaccgg     2100

tacgttttgc aaatggacca cttgaaactc agcagcagct gacaacattc ctgtcgatag     2160

gcaattgcaa tacgtttgac gacgcagccg acggttactg tcgagcagac gcagtcggca     2220

ctgtcgtcct gaaaaggctt gaagatgcgg tggcagacca tgatcctatc cttggagtca     2280

ttctaggtgc tcacactaac cactctgctg agtctgtttc tattacacgg ccgcactgcg     2340

gagcgcaaga ggaaatcttt tccaagatac ttactgagtc cggcgtccat ccccatcacg     2400

tcagctacat cgaaatgcac gggactggaa ctcaggccgg cgatgcgact gaaatggcgt     2460

cagttctcaa agtattcgct ccctcaccaa ccgctggaag attgccccat gagagccttt     2520

atttgggatc gacgaaagcc aacgtcggcc attctgagtc tgcctctggg gtcactgccc     2580

tgatcaaggt tttgttgatg atgcagaaga gcctgattcc tccgcactgc ggtatcaagg     2640

gaaagattaa ccacaaattc cccaccgacc ttgataaacg caatgtccat attgccaaag     2700

cagtgacaga gtggaggcgg cgtgaggaac tcaacaacat ccgccgtgcc tttgtaaaca     2760

acttctctgc tgccggcggc aacactgcat tgctgctgga ggactatcct gaactcacaa     2820

cgaccgcctc atctcaggat cctcgaacgg ctcacgtggt gacaatatcc gcaaagtcta     2880

tcccgtctct caaggggaat ttggcaaagc tcagagactt cgttcgacga cagtcgcaaa     2940

cagagggatt tttcgccaag ctgtcttata caaccaccgc tcgccggatg caccatccgt     3000

ttcgcgttgc tatttcggct gcaaactgcg agcagctgtt gagcgctctg gagcaagagg     3060

tgaatcgaga cgatcacaaa cgatccacag aagcacctgt cgctttcgcc ttcagcggcc     3120

aaggctcaca gtacagcgct atgggccagc atctcttaca atttgccagc tttcgagatg     3180

agattgactc ttacgaccgc ttggcgcaac ggcatgggtt cccctccatc ctgccgctta     3240

ttgatggctc atccaacatt gacgaccttg agccgctcgt tgtccaattg ggtactacgt     3300

gtgtgcagat ggcactcgcc agcttttgga tgtcgttggg aatgcagccg gcttatgtcg     3360

tcggtcacag cctgggtcac tacgccgcac tgaaagtcgc gggcgttctt acagcaagcg     3420

ataccattta cctggtaggc atgagagccc ggctacttca ggagaagtgc agcagaggaa     3480

gccatgcgat gctggcaatc cgaagcagcg tcgatcagat ccagccatat ctggatgcag     3540

cccttcatga cgttgcgtgc atcaacggac ctcaagatac cgtcgttagt ggctgtgtag     3600

atgaaatctc gagtcttgct cagaagctta cggacaatgg cgtcaaggcc acgagggtcg     3660

aagttccgtt tgcgttccac tcggcccagg tcgatccagt gttggatgaa ctcgaggcca     3720

ttgcttctca cgtcacgttc cactctccgc gcgttccaat cggttgtccc ctgttgggca     3780

agacgttcca cattggggag acgccatcgt ttgacgcaaa gcacatcagt cgtcactgca     3840

gagaagccgt caacttccgc ggcattctgc agtcagccaa agaagagggc gtaatttccg     3900

aaaagacgac ctggattgag gtgggaccac acactgtctg ctccaacctc gtcaaggcca     3960

atcttgggca agatatcacc gctgttcctt cgttagtgcg caaaaaagac ggctggcagg     4020

tactcacttc aagcctcgca actttgtact gccgaggatt gtccatcact tgggacgagt     4080

atcaccgcga ctttgaggca tgcaaagagg tattgacctt gccagcttat agctgggata     4140

acaagaggta ctggattgaa tatgtgcatg actggttgct cacacggggc gaccctcctg     4200

ttgaaccggc cgccccaatg caagcgcctt cgacattctc aactgcctcg gtgcatcgga     4260

ttgtcaatga ggtcgcagac aaaggaaagc tcaccatcac ggcggagtgc gaatttacaa     4320

acgagcagtt gcgtgaagtc gtatatggcc atgttgtcaa tggcaaccga gtttgtacgt     4380

cggtaagtat ctagcctccc tccctcctac cttatccttc ccacacttgt gcctcattgg     4440

atctctctaa caatagcata gtcattatac acggactttg gggttacctt gggtaattac     4500

attctggaga aacatcgtgt ggatctcaaa gaccactcgg tagatgtcca gaaaatggtt     4560

gttcataaag ccctagtcca caaagagggt caaccaatgc ttcttaggat cgaggtcact     4620

catgatgtaa ctctcggaaa ggacgcatcg atgtccattt acagcatcaa tcccatgggc     4680

aagaagacag ccgaccatgc acaatgcaca ctctcctttg ggcagcccaa ggtttggctc     4740

aagaactggg atggtaccct atactacgtt gagcgcagca tcgagtggct caaggggaaa     4800

gccgatcagg gtctcaacag tcgtctctcc tccggcgtga tatataagct cttttccagt     4860

ctggtcgact acagtcaggc ttataaaggc atgcaagagg ccattgtcga tgccgaagac     4920

tttgaagcta ctgctctggt ccagttccaa gttgacgagg gcagtttcca ttgcaatccg     4980

atgtggatcg acagctgtgg tcagcttgct ggatttctga tgaacggtca ttcgaagacg     5040

cccaaagacc aggttttcat caaccatggc tggcaatcgt tcagaatggt gaggaagttc     5100

cgcaaagacc agacatatcg cacatatgtc aggatgcgac ctgttgaagg aaccctctat     5160

gccggagacg tttatatctt cgatgatgat gggatcgttg gcgtctgcgg tagcattact     5220

gtaagtttgg ccctacaaag ccatccagaa tcttcggtta ctaacctgtg cgcagttcca     5280

aggtatttct cgaaaggtac tgaactcggc aatgccacct ccgaaatctg cggacgagcc     5340

tcaagtgcag acacgttctg tggtaagaac ggagcctcca aagaagatgg cggcaccaat     5400

tccgactgcc cagattgaac cgcagaagct cgaggcggct ctgaagtctg cttctgctgc     5460

ggcggttgca aaggatcccc tgcaggccgt tatcaagatt ttgtctgagg agattggtat     5520

ccccttgggc agtatccagg atgatcttgc ctttgcagac tacggagttg attcgctcct     5580

gtctctcacg atctctgggc gacttcgcga ggagcttgat ttggacgttg aatcgtcggt     5640

ctttgaggct tgcgccacat ttgctgattt catcgctcat cttggcttga ccagttcccc     5700

gtctgaccag tcttccgagc agtcaagcgt ctttgagatg gtctctccac ccagcgacag     5760

ctcggatgcc atgaccagca acgccatcac gactccaacc ggaagtttac ccgaatcggt     5820

gtctggcagc atctgcaaag acgtgtgtgc tattctggca gaggagattg gcgtgtccgc     5880

tactgacatc actaataatg caaaccttgg tgaactgggt atggactcgc ttatgtcgct     5940

gacagtgctc ggccgcctcc gcgaagagct ggacattgag ctggacgccg acttttttgt     6000

aacccacccc aactacgact ccttcaaggt cttcttccag ccagctgcca aggaacaagt     6060

tgagccagag ccgctggccg aactgaagca gtatcgggca acttcaacac tgctgcaggg     6120

cagccccaag tctgcgcttt atactctatt tctcctccca gatggatctg gttccgccac     6180

ctcatacgcc cccatcaacg caattggcaa agaagtctgt gtctacggcc tcacttgtcc     6240

ctggctgaag tcggccgaca aactggttca gttcggtctg aaaggactgg ctgctcttta     6300

cgtcgaagag attagacgcc gagtgccaca tggaccgtat aatctgggag gctggtccgc     6360

gggcggtatt tgcgcttatg aagcagcaat cagattgaca cgagatggtg aaaaggtcga     6420

acgcctgatt ctcctcgatt cgccgaatcc gattggactg gagaagcttc caccgcgact     6480

cttcgacttc gtcaacggcc taggactgtt tggagatggg aaggcgccag actggctact     6540

cgcacacttc cttgcattca tcgatgcact cgatgactgg aaaccagtgc catgggacaa     6600

ggcgctcggt ggcaaagcac caccgccaaa gacacacata ctctgggccg aggatggtct     6660

ttgcaagggc actaccgaac gcccggaata cagagacgac gatccccgag agatgcgatg     6720

gcttcttgaa aatcgaacga atttcggagg gaacaattgg gatatcttgc ttggtagtga     6780

gaaccttttg attggccgta tacaggatgc aaatcatttc acgatgctgc ataagggtaa     6840

gaacacagag cgtgttgcag agtttatcaa gagtgctttc tcaaagtaa                 6889


<210>  2
<211>  2153
<212>  PRT
<213>  Trichoderma reesei

<400>  2

Met Leu Asp Ser Thr Ser Ala Met Glu Ser Thr Thr Ile Tyr Gln Ser 
1               5                   10                  15      


Asp Ala Glu Ile Arg Ser Val Arg Val Ile Val Phe Gly Asp Gln Ser 
            20                  25                  30          


Ser Cys Ser Leu Ser Lys Leu Gln Gln Leu Leu Leu Lys Lys Asp Ser 
        35                  40                  45              


Pro Tyr Leu Thr Ser Phe Ile Asp Arg Val Asn His Thr Leu Arg His 
    50                  55                  60                  


Glu Val Ala Arg Leu Thr Thr Ala Glu Arg Gln Ser Phe Pro Ala Phe 
65                  70                  75                  80  


Cys Ser Ile Gln Asn Leu Val Ser Arg Val Leu Lys Thr Asp Lys His 
                85                  90                  95      


Thr Glu Asn Ala Ala Val Glu Ser Thr Leu Ala Thr Val Tyr Gln Leu 
            100                 105                 110         


Cys Cys Phe Phe Ser His Phe Gly Asn Gly Gln Glu Thr Tyr Pro Thr 
        115                 120                 125             


Gly Pro Asp Thr His Val Ser Gly Leu Cys Ile Gly Ala Leu Ala Ala 
    130                 135                 140                 


Ala Ala Val Ser Ser Ser Arg Ser Leu Gly Glu Leu Val Glu Ala Gly 
145                 150                 155                 160 


Ile Asp Ala Val Arg Val Ser Leu Arg Val Gly Leu Leu Val Ala Arg 
                165                 170                 175     


Thr Ala Ala Leu Phe Gly Gln Pro Gln Ser Thr Gly Thr Ser Ser Trp 
            180                 185                 190         


Ser Tyr Val Val Pro Glu Ser Gln Ile Pro Leu Ala Phe Ala Glu Lys 
        195                 200                 205             


Ala Ile Ser Ser Tyr Asn Asp Glu Ser Asn Ile Pro Pro Leu Ser Ser 
    210                 215                 220                 


Pro Tyr Ile Ser Ala Lys Gly Gln Asn Ser Trp Thr Leu Ser Gly Pro 
225                 230                 235                 240 


Pro Ala Val Val Gln His Phe Leu Gln Ser Ser Gln Phe Ser Gly Lys 
                245                 250                 255     


Leu Lys Ile Thr Pro Ile Ala Val His Ala Pro Tyr His Ala Ser His 
            260                 265                 270         


Ile Phe Ser Val Arg Asp Ile Glu Gln Leu Leu Arg Asp Val Gly Ser 
        275                 280                 285             


Val Ser Gly Leu Thr Ser Lys Leu Pro Phe Ile Pro Ser Ser Thr Glu 
    290                 295                 300                 


Arg Ser Pro Leu Gln Gly Ala Gln Phe Gln Asp Leu Leu Gln His Val 
305                 310                 315                 320 


Leu Glu Gly Ile Leu Ile Gln Pro Leu Asp Leu Arg Glu Ala Ala Glu 
                325                 330                 335     


Asn Ile Gln Lys Val Phe Glu Ala Ala Gly Pro Thr Gly Gln Cys Ala 
            340                 345                 350         


Leu Leu Pro Val Ser Thr Ser Val Cys Ser Ser Leu Lys Val Ser Phe 
        355                 360                 365             


Pro Pro Pro Leu Ser Arg Arg Val Ala Val Leu Asp Ser Ile Thr Glu 
    370                 375                 380                 


Gly Ile Ala Val Ser Thr Val Ser Asn Pro Pro Gly Thr Gly Arg Pro 
385                 390                 395                 400 


Ala Asp Ser Lys Ile Ala Ile Val Gly Met Ser Gly Arg Phe Pro Glu 
                405                 410                 415     


Ser Ala Asp Val Glu Ala Phe Trp Asp Leu Leu Tyr Gln Gly Leu Asp 
            420                 425                 430         


Val His Arg Arg Val Pro Ala Asp Arg Tyr Asn Ala Glu Leu Tyr Tyr 
        435                 440                 445             


Asp Pro Thr Gly Lys Arg Lys Asn Thr Ser Lys Ile Met His Gly Cys 
    450                 455                 460                 


Trp Ile Asn Glu Pro Gly Leu Phe Asp Ala Lys Phe Phe Asn Ile Ser 
465                 470                 475                 480 


Pro Lys Glu Ala Glu Gln Ser Asp Pro Gly Gln Arg Leu Ala Leu Ala 
                485                 490                 495     


Thr Ala Tyr Glu Ala Leu Glu Met Ala Gly Ile Val Ala Asp Arg Thr 
            500                 505                 510         


Pro Ser Thr Gln Arg Asp Arg Val Gly Val Phe Tyr Gly Met Thr Ser 
        515                 520                 525             


Asp Asp Tyr Arg Glu Val Ser Cys Gly Gln Asn Val Asp Thr Tyr Phe 
    530                 535                 540                 


Ile Pro Gly Gly Asn Arg Ala Phe Thr Pro Gly Lys Ile Asn Tyr Phe 
545                 550                 555                 560 


Phe Lys Tyr Cys Gly Pro Ser Val Ser Val Asp Thr Ala Cys Ser Ser 
                565                 570                 575     


Ser Leu Ala Ala Ile His Leu Ala Cys Asn Ser Ile Trp Arg Asn Glu 
            580                 585                 590         


Cys Asp Thr Ala Val Ala Gly Gly Thr Asn Val Met Ser Asn Pro Asp 
        595                 600                 605             


Ser Phe Ala Gly Leu Asp Arg Gly His Phe Leu Ser Arg Thr Gly Asn 
    610                 615                 620                 


Cys Asn Thr Phe Asp Asp Ala Ala Asp Gly Tyr Cys Arg Ala Asp Ala 
625                 630                 635                 640 


Val Gly Thr Val Val Leu Lys Arg Leu Glu Asp Ala Val Ala Asp His 
                645                 650                 655     


Asp Pro Ile Leu Gly Val Ile Leu Gly Ala His Thr Asn His Ser Ala 
            660                 665                 670         


Glu Ser Val Ser Ile Thr Arg Pro His Cys Gly Ala Gln Glu Glu Ile 
        675                 680                 685             


Phe Ser Lys Ile Leu Thr Glu Ser Gly Val His Pro His His Val Ser 
    690                 695                 700                 


Tyr Ile Glu Met His Gly Thr Gly Thr Gln Ala Gly Asp Ala Thr Glu 
705                 710                 715                 720 


Met Ala Ser Val Leu Lys Val Phe Ala Pro Ser Pro Thr Ala Gly Arg 
                725                 730                 735     


Leu Pro His Glu Ser Leu Tyr Leu Gly Ser Thr Lys Ala Asn Val Gly 
            740                 745                 750         


His Ser Glu Ser Ala Ser Gly Val Thr Ala Leu Ile Lys Val Leu Leu 
        755                 760                 765             


Met Met Gln Lys Ser Leu Ile Pro Pro His Cys Gly Ile Lys Gly Lys 
    770                 775                 780                 


Ile Asn His Lys Phe Pro Thr Asp Leu Asp Lys Arg Asn Val His Ile 
785                 790                 795                 800 


Ala Lys Ala Val Thr Glu Trp Arg Arg Arg Glu Glu Leu Asn Asn Ile 
                805                 810                 815     


Arg Arg Ala Phe Val Asn Asn Phe Ser Ala Ala Gly Gly Asn Thr Ala 
            820                 825                 830         


Leu Leu Leu Glu Asp Tyr Pro Glu Leu Thr Thr Thr Ala Ser Ser Gln 
        835                 840                 845             


Asp Pro Arg Thr Ala His Val Val Thr Ile Ser Ala Lys Ser Ile Pro 
    850                 855                 860                 


Ser Leu Lys Gly Asn Leu Ala Lys Leu Arg Asp Phe Val Arg Arg Gln 
865                 870                 875                 880 


Ser Gln Thr Glu Gly Phe Phe Ala Lys Leu Ser Tyr Thr Thr Thr Ala 
                885                 890                 895     


Arg Arg Met His His Pro Phe Arg Val Ala Ile Ser Ala Ala Asn Cys 
            900                 905                 910         


Glu Gln Leu Leu Ser Ala Leu Glu Gln Glu Val Asn Arg Asp Asp His 
        915                 920                 925             


Lys Arg Ser Thr Glu Ala Pro Val Ala Phe Ala Phe Ser Gly Gln Gly 
    930                 935                 940                 


Ser Gln Tyr Ser Ala Met Gly Gln His Leu Leu Gln Phe Ala Ser Phe 
945                 950                 955                 960 


Arg Asp Glu Ile Asp Ser Tyr Asp Arg Leu Ala Gln Arg His Gly Phe 
                965                 970                 975     


Pro Ser Ile Leu Pro Leu Ile Asp Gly Ser Ser Asn Ile Asp Asp Leu 
            980                 985                 990         


Glu Pro Leu Val Val Gln Leu Gly  Thr Thr Cys Val Gln  Met Ala Leu 
        995                 1000                 1005             


Ala Ser  Phe Trp Met Ser Leu  Gly Met Gln Pro Ala  Tyr Val Val 
    1010                 1015                 1020             


Gly His  Ser Leu Gly His Tyr  Ala Ala Leu Lys Val  Ala Gly Val 
    1025                 1030                 1035             


Leu Thr  Ala Ser Asp Thr Ile  Tyr Leu Val Gly Met  Arg Ala Arg 
    1040                 1045                 1050             


Leu Leu  Gln Glu Lys Cys Ser  Arg Gly Ser His Ala  Met Leu Ala 
    1055                 1060                 1065             


Ile Arg  Ser Ser Val Asp Gln  Ile Gln Pro Tyr Leu  Asp Ala Ala 
    1070                 1075                 1080             


Leu His  Asp Val Ala Cys Ile  Asn Gly Pro Gln Asp  Thr Val Val 
    1085                 1090                 1095             


Ser Gly  Cys Val Asp Glu Ile  Ser Ser Leu Ala Gln  Lys Leu Thr 
    1100                 1105                 1110             


Asp Asn  Gly Val Lys Ala Thr  Arg Val Glu Val Pro  Phe Ala Phe 
    1115                 1120                 1125             


His Ser  Ala Gln Val Asp Pro  Val Leu Asp Glu Leu  Glu Ala Ile 
    1130                 1135                 1140             


Ala Ser  His Val Thr Phe His  Ser Pro Arg Val Pro  Ile Gly Cys 
    1145                 1150                 1155             


Pro Leu  Leu Gly Lys Thr Phe  His Ile Gly Glu Thr  Pro Ser Phe 
    1160                 1165                 1170             


Asp Ala  Lys His Ile Ser Arg  His Cys Arg Glu Ala  Val Asn Phe 
    1175                 1180                 1185             


Arg Gly  Ile Leu Gln Ser Ala  Lys Glu Glu Gly Val  Ile Ser Glu 
    1190                 1195                 1200             


Lys Thr  Thr Trp Ile Glu Val  Gly Pro His Thr Val  Cys Ser Asn 
    1205                 1210                 1215             


Leu Val  Lys Ala Asn Leu Gly  Gln Asp Ile Thr Ala  Val Pro Ser 
    1220                 1225                 1230             


Leu Val  Arg Lys Lys Asp Gly  Trp Gln Val Leu Thr  Ser Ser Leu 
    1235                 1240                 1245             


Ala Thr  Leu Tyr Cys Arg Gly  Leu Ser Ile Thr Trp  Asp Glu Tyr 
    1250                 1255                 1260             


His Arg  Asp Phe Glu Ala Cys  Lys Glu Val Leu Thr  Leu Pro Ala 
    1265                 1270                 1275             


Tyr Ser  Trp Asp Asn Lys Arg  Tyr Trp Ile Glu Tyr  Val His Asp 
    1280                 1285                 1290             


Trp Leu  Leu Thr Arg Gly Asp  Pro Pro Val Glu Pro  Ala Ala Pro 
    1295                 1300                 1305             


Met Gln  Ala Pro Ser Thr Phe  Ser Thr Ala Ser Val  His Arg Ile 
    1310                 1315                 1320             


Val Asn  Glu Val Ala Asp Lys  Gly Lys Leu Thr Ile  Thr Ala Glu 
    1325                 1330                 1335             


Cys Glu  Phe Thr Asn Glu Gln  Leu Arg Glu Val Val  Tyr Gly His 
    1340                 1345                 1350             


Val Val  Asn Gly Asn Arg Val  Cys Thr Ser Ser Leu  Tyr Thr Asp 
    1355                 1360                 1365             


Phe Gly  Val Thr Leu Gly Asn  Tyr Ile Leu Glu Lys  His Arg Val 
    1370                 1375                 1380             


Asp Leu  Lys Asp His Ser Val  Asp Val Gln Lys Met  Val Val His 
    1385                 1390                 1395             


Lys Ala  Leu Val His Lys Glu  Gly Gln Pro Met Leu  Leu Arg Ile 
    1400                 1405                 1410             


Glu Val  Thr His Asp Val Thr  Leu Gly Lys Asp Ala  Ser Met Ser 
    1415                 1420                 1425             


Ile Tyr  Ser Ile Asn Pro Met  Gly Lys Lys Thr Ala  Asp His Ala 
    1430                 1435                 1440             


Gln Cys  Thr Leu Ser Phe Gly  Gln Pro Lys Val Trp  Leu Lys Asn 
    1445                 1450                 1455             


Trp Asp  Gly Thr Leu Tyr Tyr  Val Glu Arg Ser Ile  Glu Trp Leu 
    1460                 1465                 1470             


Lys Gly  Lys Ala Asp Gln Gly  Leu Asn Ser Arg Leu  Ser Ser Gly 
    1475                 1480                 1485             


Val Ile  Tyr Lys Leu Phe Ser  Ser Leu Val Asp Tyr  Ser Gln Ala 
    1490                 1495                 1500             


Tyr Lys  Gly Met Gln Glu Ala  Ile Val Asp Ala Glu  Asp Phe Glu 
    1505                 1510                 1515             


Ala Thr  Ala Leu Val Gln Phe  Gln Val Asp Glu Gly  Ser Phe His 
    1520                 1525                 1530             


Cys Asn  Pro Met Trp Ile Asp  Ser Cys Gly Gln Leu  Ala Gly Phe 
    1535                 1540                 1545             


Leu Met  Asn Gly His Ser Lys  Thr Pro Lys Asp Gln  Val Phe Ile 
    1550                 1555                 1560             


Asn His  Gly Trp Gln Ser Phe  Arg Met Val Arg Lys  Phe Arg Lys 
    1565                 1570                 1575             


Asp Gln  Thr Tyr Arg Thr Tyr  Val Arg Met Arg Pro  Val Glu Gly 
    1580                 1585                 1590             


Thr Leu  Tyr Ala Gly Asp Val  Tyr Ile Phe Asp Asp  Asp Gly Ile 
    1595                 1600                 1605             


Val Gly  Val Cys Gly Ser Ile  Thr Phe Gln Gly Ile  Ser Arg Lys 
    1610                 1615                 1620             


Val Leu  Asn Ser Ala Met Pro  Pro Pro Lys Ser Ala  Asp Glu Pro 
    1625                 1630                 1635             


Gln Val  Gln Thr Arg Ser Val  Val Arg Thr Glu Pro  Pro Lys Lys 
    1640                 1645                 1650             


Met Ala  Ala Pro Ile Pro Thr  Ala Gln Ile Glu Pro  Gln Lys Leu 
    1655                 1660                 1665             


Glu Ala  Ala Leu Lys Ser Ala  Ser Ala Ala Ala Val  Ala Lys Asp 
    1670                 1675                 1680             


Pro Leu  Gln Ala Val Ile Lys  Ile Leu Ser Glu Glu  Ile Gly Ile 
    1685                 1690                 1695             


Pro Leu  Gly Ser Ile Gln Asp  Asp Leu Ala Phe Ala  Asp Tyr Gly 
    1700                 1705                 1710             


Val Asp  Ser Leu Leu Ser Leu  Thr Ile Ser Gly Arg  Leu Arg Glu 
    1715                 1720                 1725             


Glu Leu  Asp Leu Asp Val Glu  Ser Ser Val Phe Glu  Ala Cys Ala 
    1730                 1735                 1740             


Thr Phe  Ala Asp Phe Ile Ala  His Leu Gly Leu Thr  Ser Ser Pro 
    1745                 1750                 1755             


Ser Asp  Gln Ser Ser Glu Gln  Ser Ser Val Phe Glu  Met Val Ser 
    1760                 1765                 1770             


Pro Pro  Ser Asp Ser Ser Asp  Ala Met Thr Ser Asn  Ala Ile Thr 
    1775                 1780                 1785             


Thr Pro  Thr Gly Ser Leu Pro  Glu Ser Val Ser Gly  Ser Ile Cys 
    1790                 1795                 1800             


Lys Asp  Val Cys Ala Ile Leu  Ala Glu Glu Ile Gly  Val Ser Ala 
    1805                 1810                 1815             


Thr Asp  Ile Thr Asn Asn Ala  Asn Leu Gly Glu Leu  Gly Met Asp 
    1820                 1825                 1830             


Ser Leu  Met Ser Leu Thr Val  Leu Gly Arg Leu Arg  Glu Glu Leu 
    1835                 1840                 1845             


Asp Ile  Glu Leu Asp Ala Asp  Phe Phe Val Thr His  Pro Asn Tyr 
    1850                 1855                 1860             


Asp Ser  Phe Lys Val Phe Phe  Gln Pro Ala Ala Lys  Glu Gln Val 
    1865                 1870                 1875             


Glu Pro  Glu Pro Leu Ala Glu  Leu Lys Gln Tyr Arg  Ala Thr Ser 
    1880                 1885                 1890             


Thr Leu  Leu Gln Gly Ser Pro  Lys Ser Ala Leu Tyr  Thr Leu Phe 
    1895                 1900                 1905             


Leu Leu  Pro Asp Gly Ser Gly  Ser Ala Thr Ser Tyr  Ala Pro Ile 
    1910                 1915                 1920             


Asn Ala  Ile Gly Lys Glu Val  Cys Val Tyr Gly Leu  Thr Cys Pro 
    1925                 1930                 1935             


Trp Leu  Lys Ser Ala Asp Lys  Leu Val Gln Phe Gly  Leu Lys Gly 
    1940                 1945                 1950             


Leu Ala  Ala Leu Tyr Val Glu  Glu Ile Arg Arg Arg  Val Pro His 
    1955                 1960                 1965             


Gly Pro  Tyr Asn Leu Gly Gly  Trp Ser Ala Gly Gly  Ile Cys Ala 
    1970                 1975                 1980             


Tyr Glu  Ala Ala Ile Arg Leu  Thr Arg Asp Gly Glu  Lys Val Glu 
    1985                 1990                 1995             


Arg Leu  Ile Leu Leu Asp Ser  Pro Asn Pro Ile Gly  Leu Glu Lys 
    2000                 2005                 2010             


Leu Pro  Pro Arg Leu Phe Asp  Phe Val Asn Gly Leu  Gly Leu Phe 
    2015                 2020                 2025             


Gly Asp  Gly Lys Ala Pro Asp  Trp Leu Leu Ala His  Phe Leu Ala 
    2030                 2035                 2040             


Phe Ile  Asp Ala Leu Asp Asp  Trp Lys Pro Val Pro  Trp Asp Lys 
    2045                 2050                 2055             


Ala Leu  Gly Gly Lys Ala Pro  Pro Pro Lys Thr His  Ile Leu Trp 
    2060                 2065                 2070             


Ala Glu  Asp Gly Leu Cys Lys  Gly Thr Thr Glu Arg  Pro Glu Tyr 
    2075                 2080                 2085             


Arg Asp  Asp Asp Pro Arg Glu  Met Arg Trp Leu Leu  Glu Asn Arg 
    2090                 2095                 2100             


Thr Asn  Phe Gly Gly Asn Asn  Trp Asp Ile Leu Leu  Gly Ser Glu 
    2105                 2110                 2115             


Asn Leu  Leu Ile Gly Arg Ile  Gln Asp Ala Asn His  Phe Thr Met 
    2120                 2125                 2130             


Leu His  Lys Gly Lys Asn Thr  Glu Arg Val Ala Glu  Phe Ile Lys 
    2135                 2140                 2145             


Ser Ala  Phe Ser Lys 
    2150             


<210>  3
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  3
gagcacccgt tttcatgcat tctacgccag gaccgagcaa                             40


<210>  4
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  4
gcattggcgg cctatgcatc tggaaacgca accctgaagg                             40


<210>  5
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  5
gtcgacctgc aggcatgcgt ttaaaccaaa gaccttacaa ttagct                      46


<210>  6
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  6
ggtcctggcg tagaatgcat gaaaacgggt gctccaaata                             40


<210>  7
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  7
ggttgcgttt ccagatgcat aggccgccaa tgctcttgac aaa                         43


<210>  8
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  8
gctatgacca tgattacgcc gtttaaaccg cagccatgag tatcacgc                    48


<210>  9
<211>  10367
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid pSMai268

<400>  9
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt cgagctcggt acccggggat      420

cctctagagt cgacctgcag gttcatttaa acggcttcac gggcagccca gcggtcgatt      480

tcgcttccaa attttggggg aaagggtccc tgagcagcct cacaaacgca aacatgcgca      540

cgcgccacac ggaaaatgaa gctgactttg aatttttaag aatccccttt gcccgtggca      600

ccttctgatt tttgtcttcg tgtccaatcc atctccttga acgacaaccc agccctttct      660

atttcctatc ccctaatatc taatgtgagt cctcatcgtc acagacggcg acggacgcga      720

catttcgccc gtgctcatcg accgctctgc tgtcgccaac agaacacgcg gttatgtcgc      780

gttccgcttt gtcgtaccac tttcgcccca caccgctgac ctcgcgttcc cagcatgaaa      840

aagcctgaac tcaccgcgac gtctgtcgag aagtttctga tcgaaaagtt cgacagcgtc      900

tccgacctga tgcagctctc ggagggcgaa gaatctcgtg ctttcagctt cgatgtagga      960

gggcgtggat atgtcctgcg ggtaaatagc tgcgccgatg gtttctacaa agatcgttat     1020

gtttatcggc actttgcatc ggccgcgctc ccgattccgg aagtgcttga cattggggag     1080

ttcagcgaga gcctgaccta ttgcatctcc cgccgtgcac agggtgtcac gttgcaagac     1140

ctgcctgaaa ccgaactgcc cgctgttctg cagccggtcg cggaggccat ggatgcgatc     1200

gctgcggccg atcttagcca gacgagcggg ttcggcccat tcggaccgca aggaatcggt     1260

caatacacta catggcgtga tttcatatgc gcgattgctg atccccatgt gtatcactgg     1320

caaactgtga tggacgacac cgtcagtgcg tccgtcgcgc aggctctcga tgagctgatg     1380

ctttgggccg aggactgccc cgaagtccgg cacctcgtgc acgcggattt cggctccaac     1440

aatgtcctga cggacaatgg ccgcataaca gcggtcattg actggagcga ggcgatgttc     1500

ggggattccc aatacgaggt cgccaacatc ttcttctgga ggccgtggtt ggcttgtatg     1560

gagcagcaga cgcgctactt cgagcggagg catccggagc ttgcaggatc gccgcggctc     1620

cgggcgtata tgctccgcat tggtcttgac caactctatc agagcttggt tgacggcaat     1680

ttcgatgatg cagcttgggc gcagggtcga tgcgacgcaa tcgtccgatc cggagccggg     1740

actgtcgggc gtacacaaat cgcccgcaga agcgcggccg tctggaccga tggctgtgta     1800

gaagtactcg ccgatagtgg aaaccgacgc cccagcactc gtccgagggc aaggaatagt     1860

aaatgattcg ttagttcttt cctgaactga tgattcgcgc gattcgtatt tctctttgtt     1920

ggttgttctg atgatgatga aaatgacgca tctctttatt tgctgcactc gtacacccat     1980

cctttggaat gattaatacc cctccttttt catcgcggac ggtagtcgtt ctctttgggg     2040

ccgtgtttct tcccattcgc atgcgacctc gtggtcattg actgtctgtc ctcttcctct     2100

ccacctacct ccaccaccta cgttgactgc atatcacttt ttcaaacatt catgataata     2160

cgctaccttc tggcatgacc ttttgatgat cgctttttac tatcctttca attacgatgt     2220

tgtcacttct atttgtcatt ttgcggaatt agtattttct ttccatcttc gatggagaga     2280

tgaatattgc ctgcaggcat gcaagctttc tgctcgaggc catctggctt ttctctgctg     2340

tctgcctcgg gaatgggatg gaataccacg tacggtattt ggcctccggt gccatccgaa     2400

gcgagatgct ttgagcttga aaccccctcg gcctgcacag gtgtctcatc gtgcatttaa     2460

tccaacggcg gcgagtcaaa acatcagcta attgaccagg tttctggatt gtgaatgcca     2520

actttttggg tcttgaggag ttgcggggtg ggaaaaaagt aaagaaattt actgaggatt     2580

ttatcattgc gactataaaa taaagcggca ttgcaaatcc ttgcgttgct actatgtaaa     2640

atggactgta gttgtgctgc tgaaaatagt ttggcgattg tggattgtgg attgtggatt     2700

gtggattatg gcaagttgtc aaggggcaag ttgacgaaaa tgattgtgtg gtgtctgcca     2760

gcaaattgag aacgtgggta tatatttcat cttttcatga ttcccttcaa gatcctcacc     2820

cgcctcttgt tttagagcta gaaatagcaa gttaaaataa ggctagtccg ttatcaactt     2880

gaaaaagtgg caccgagtcg gtgctttttt taagcttcga gacagcagaa tcaccgccca     2940

agttaagcct ttgtgctgat catgctctcg aacgggccaa gttcgggaaa agcaaaggag     3000

cgtttagtga ggggcaattt gactcacctc ccaggcaaca gatgaggggg gcaaaaagaa     3060

agaaattttc gtgagtcaat atggattccg agcatcattt tcttgcggtc tatcttgcta     3120

cgtatgttga tcttgacgct gtggatcaag caacgccact cgctcgctcc atcgcaggct     3180

ggtcgcagac aaattaaaag gcggcaaact cgtacagccg cggggttgtc cgctgcaaag     3240

tacagagtga taaaagccgc catgcgacca tcaacgcgtt gatgcccagc tttttcgatc     3300

cgagaatcca ccgtagaggc gatagcaagt aaagaaaagc taaacaaaaa aaaatttctg     3360

cccctaagcc atgaaaacga gatggggtgg agcagaacca aggaaagagt cgcgctgggc     3420

tgccgttccg gaaggtgttg taaaggctcg acgcccaagg tgggagtcta ggagaagaat     3480

ttgcatcggg agtggggcgg gttacccctc catatccaat gacagatatc taccagccaa     3540

gggtttgagc ccgcccgctt agtcgtcgtc ctcgcttgcc cctccataaa aggatttccc     3600

ctccccctcc cacaaaattt tctttccctt cctctccttg tccgcttcag tacgtatatc     3660

ttcccttccc tcgcttctct cctccatcct tctttcatcc atctcctgct aacttctctg     3720

ctcagcacct ctacgcatta ctagccgtag tatctgagca cttctccctt ttatattcca     3780

caaaacataa cacaaccttc accatggaca agaagtatag catcgggctg gacattggaa     3840

cgaactcggt tggttgggct gtgattacgg acgaatacaa ggtgccatcc aagaagttta     3900

aggtcctggg aaacaccgac cgtcactcaa tcaagaagaa tctcattgga gccctgctct     3960

tcgatagtgg ggagaccgcc gaagctactc gactgaagcg aacggctcgc cggcgttata     4020

cacgacgcaa gaatcgcatc tgctacctcc aggagatttt cagcaacgaa atggctaagg     4080

ttgatgactc attctttcat cgactcgaag aaagtttctt ggtcgaggag gataagaagc     4140

acgagcgcca tccgatcttt ggtaacattg tggatgaggt tgcctatcac gaaaagtacc     4200

caactatcta tcatcttcgt aagaagctgg tcgatagcac ggacaaggct gatttgcgac     4260

ttatctacct ggcactcgcg cacatgatta agttccgcgg ccattttctt atcgagggtg     4320

acctgaaccc cgataattct gacgttgata agctcttcat ccagttggtc caaacctaca     4380

atcagctgtt tgaggaaaac cctattaatg catctggcgt ggacgccaag gctatccttt     4440

cggcgcgcct gtctaagtcg cggcgtttgg agaaccttat cgcacaactc cccggcgaaa     4500

agaagaacgg cctcttcggt aatttgattg cgttgtcact tggtctgact cctaacttca     4560

agagtaattt tgacctggca gaggatgcga agctccagtt gtctaaggat acgtatgatg     4620

acgatctcga caacttgctt gcccaaatcg gtgaccagta cgctgatctt ttcctggccg     4680

ctaagaatct ctcagatgca atcctgctca gtgacatttt gcgggtcaac accgagatta     4740

ctaaggcccc cctgtcagct agtatgatca agcggtatga tgagcaccat caggacctca     4800

ccttgcttaa ggccctcgtg cgtcagcaat tgcctgagaa gtacaaggaa atcttctttg     4860

accaatccaa gaacggatac gcagggtata ttgatggcgg tgcgagccag gaggaattct     4920

acaagtttat caagccgatt ttggagaaga tggacggcac tgaggaactg ctcgtcaagc     4980

tgaatcgcga agatttgctt cgtaagcaac gaacgttcga caacggctcc atcccgcacc     5040

agattcatct gggcgagctc cacgccatcc ttcgacgcca ggaagatttc tacccatttc     5100

tgaaggacaa ccgtgagaag atcgaaaaga ttcttacatt ccgaatcccc tactatgtgg     5160

gacctttggc ccgtgggaat tcccgatttg cttggatgac ccgaaagagc gaggaaacca     5220

tcactccgtg gaacttcgag gaagtcgtgg acaagggtgc atccgcgcag agcttcattg     5280

agcggatgac caattttgat aagaaccttc cgaatgaaaa ggtcctgcca aagcattcgc     5340

tgctctacga gtatttcacc gtgtataacg aactgactaa ggtcaagtac gtgacggagg     5400

gaatgcggaa gccagccttc ctctcagggg aacaaaagaa ggctatcgtc gatttgcttt     5460

ttaagaccaa tcgtaaagtg actgttaagc agctgaagga ggattatttc aagaagattg     5520

aatgtttcga ctccgtcgag atcagcggcg tggaagatcg ctttaacgct tccctcggta     5580

cctaccacga cctgctcaag atcattaagg acaaggattt cctcgataac gaggaaaatg     5640

aggacatctt ggaagatatt gtcctcacgt tgacactttt tgaggaccgc gaaatgatcg     5700

aggaacggct caagacatat gcccatttgt tcgacgataa ggtgatgaag cagctgaagc     5760

ggcgtcgata caccggatgg ggtcgcctta gccggaagct gatcaacggc attcgagata     5820

agcaatctgg taagactatc ttggatttcc ttaagtcgga cggcttcgcc aaccgcaatt     5880

ttatgcagct tattcacgac gattccctga cgttcaagga ggacatccag aaggcacaag     5940

tctcaggaca aggggattcc ctgcacgagc atatcgccaa cctggctgga tccccggcga     6000

tcaagaaggg gattcttcag accgtcaagg ttgtcgacga gctggtcaag gtgatgggcc     6060

gtcataagcc agaaaacatc gtgattgaga tggcccgaga aaatcagacc actcaaaagg     6120

gtcagaagaa cagccgcgag cggatgaagc ggatcgagga aggcattaag gaacttggtt     6180

ctcagatcct gaaggagcac cctgttgaaa acacacagct ccaaaatgag aagctgtatc     6240

tctactattt gcaaaatgga cgcgacatgt acgtcgatca ggagctcgac attaaccggt     6300

tgtcggacta cgatgttgac catatcgtcc cgcaatcctt ccttaaggac gatagcattg     6360

ataacaaggt gctgactcgc tcagataaga accggggcaa gtccgacaat gttccaagcg     6420

aggaagtggt taagaagatg aagaactact ggcgccaatt gcttaatgcc aagctcatca     6480

cacagcgcaa gtttgacaac ttgaccaagg ccgagcgggg agggctgagt gaactcgata     6540

aggctggctt catcaagcgt caactcgtgg agacgcgaca gatcacaaag cacgttgctc     6600

agattctgga ctcccggatg aacacaaagt acgacgagaa tgataagctc atccgtgaag     6660

ttaaggtcat taccctcaag tctaagttgg tgtcggattt ccgcaaggac ttccaatttt     6720

ataaggttcg ggagatcaac aattatcacc atgcacatga tgcgtacctc aacgcagtcg     6780

tgggaactgc gctcatcaag aagtatccca agttggagtc cgaattcgtc tacggggatt     6840

ataaggttta cgacgtccgc aagatgatcg ccaagagtga gcaggaaatt ggcaaggcca     6900

cggctaagta tttcttttac tccaacatca tgaatttctt taagacggag atcacactcg     6960

ccaatggaga aatccgtaag cgacctttga ttgagaccaa cggcgagact ggtgaaatcg     7020

tttgggataa ggggcgcgac ttcgctaccg tgcggaaggt tctgagcatg ccgcaagtca     7080

atatcgtcaa gaaaaccgag gtgcagacag gcggtttctc taaggaatcg attcttccaa     7140

agcgtaactc tgacaagctg atcgctcgaa agaaggattg ggaccccaag aagtatggag     7200

ggttcgattc tcctacagtg gcatactcgg ttctcgttgt cgcgaaggtt gagaagggaa     7260

agtctaagaa gctgaagtcg gtcaaggaac tgctcgggat caccattatg gagcgctcca     7320

gcttcgaaaa gaatcccatc gactttctcg aggccaaggg ctataaggaa gtcaagaagg     7380

atcttatcat taagctgcct aagtactctt tgttcgagct tgaaaacggt cgaaagcgaa     7440

tgctcgcatc ggcaggagag ttgcagaagg ggaatgaatt ggcacttccc tcaaagtacg     7500

tgaacttcct gtatctcgcg tcccactacg agaagctgaa gggtagccct gaggacaacg     7560

aacagaagca actttttgtt gagcaacaca agcattatct ggatgagatc attgaacaga     7620

tttcagagtt cagtaagcgc gtcatcctcg ccgatgctaa tctcgacaag gtgttgtcgg     7680

cctacaacaa gcaccgtgac aagccgatcc gagagcaggc tgaaaatatc attcatctgt     7740

tcaccctcac taacttggga gcaccagcag cgttcaagta ttttgatacg acaatcgacc     7800

gtaagcgata cacgtccaca aaggaggtgc ttgatgcgac cctgattcat caatccatca     7860

ctgggctcta tgaaacccgt atcgacctta gtcaactggg gggcgacccc cccaagaaga     7920

agcgcaaggt ctgagcggac attcgattta tgccgttatg acttccttaa aaaagccttt     7980

acgaatgaaa gaaatggaat tagacttgtt atgtagttga ttctacaatg gattatgatt     8040

cctgaacttc aaatccgctg ttcattatta atctcagctc ttcccgtaaa gccaatgttg     8100

aaactattcg taaatgtacc tcgttttgcg tgtggcgtaa tcatggtcat agctgtttcc     8160

tgtgtgaaat tgttatccgc tcacaattcc acacaacata cgagccggaa gcataaagtg     8220

taaagcctgg ggtgcctaat gagtgagcta actcacatta attgcgttgc gctcactgcc     8280

cgctttccag tcgggaaacc tgtcgtgcca gctgcattaa tgaatcggcc aacgcgcggg     8340

gagaggcggt ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc     8400

ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac     8460

agaatcaggg gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa     8520

ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca     8580

caaaaatcga cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc     8640

gtttccccct ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata     8700

cctgtccgcc tttctccctt cgggaagcgt ggcgctttct catagctcac gctgtaggta     8760

tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca     8820

gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga     8880

cttatcgcca ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg     8940

tgctacagag ttcttgaagt ggtggcctaa ctacggctac actagaagga cagtatttgg     9000

tatctgcgct ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg     9060

caaacaaacc accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag     9120

aaaaaaagga tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa     9180

cgaaaactca cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat     9240

ccttttaaat taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc     9300

tgacagttac caatgcttaa tcagtgaggc acctatctca gcgatctgtc tatttcgttc     9360

atccatagtt gcctgactcc ccgtcgtgta gataactacg atacgggagg gcttaccatc     9420

tggccccagt gctgcaatga taccgcgaga cccacgctca ccggctccag atttatcagc     9480

aataaaccag ccagccggaa gggccgagcg cagaagtggt cctgcaactt tatccgcctc     9540

catccagtct attaattgtt gccgggaagc tagagtaagt agttcgccag ttaatagttt     9600

gcgcaacgtt gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc     9660

ttcattcagc tccggttccc aacgatcaag gcgagttaca tgatccccca tgttgtgcaa     9720

aaaagcggtt agctccttcg gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt     9780

atcactcatg gttatggcag cactgcataa ttctcttact gtcatgccat ccgtaagatg     9840

cttttctgtg actggtgagt actcaaccaa gtcattctga gaatagtgta tgcggcgacc     9900

gagttgctct tgcccggcgt caatacggga taataccgcg ccacatagca gaactttaaa     9960

agtgctcatc attggaaaac gttcttcggg gcgaaaactc tcaaggatct taccgctgtt    10020

gagatccagt tcgatgtaac ccactcgtgc acccaactga tcttcagcat cttttacttt    10080

caccagcgtt tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa agggaataag    10140

ggcgacacgg aaatgttgaa tactcatact cttccttttt caatattatt gaagcattta    10200

tcagggttat tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat    10260

aggggttccg cgcacatttc cccgaaaagt gccacctgac gtctaagaaa ccattattat    10320

catgacatta acctataaaa ataggcgtat cacgaggccc tttcgtc                  10367


<210>  10
<211>  4107
<212>  DNA
<213>  Streptococcus pyogenes

<400>  10
atggataaga aatactcaat aggcttagat atcggcacaa atagcgtcgg atgggcggtg       60

atcactgatg aatataaggt tccgtctaaa aagttcaagg ttctgggaaa tacagaccgc      120

cacagtatca aaaaaaatct tataggggct cttttatttg acagtggaga gacagcggaa      180

gcgactcgtc tcaaacggac agctcgtaga aggtatacac gtcggaagaa tcgtatttgt      240

tatctacagg agattttttc aaatgagatg gcgaaagtag atgatagttt ctttcatcga      300

cttgaagagt cttttttggt ggaagaagac aagaagcatg aacgtcatcc tatttttgga      360

aatatagtag atgaagttgc ttatcatgag aaatatccaa ctatctatca tctgcgaaaa      420

aaattggtag attctactga taaagcggat ttgcgcttaa tctatttggc cttagcgcat      480

atgattaagt ttcgtggtca ttttttgatt gagggagatt taaatcctga taatagtgat      540

gtggacaaac tatttatcca gttggtacaa acctacaatc aattatttga agaaaaccct      600

attaacgcaa gtggagtaga tgctaaagcg attctttctg cacgattgag taaatcaaga      660

cgattagaaa atctcattgc tcagctcccc ggtgagaaga aaaatggctt atttgggaat      720

ctcattgctt tgtcattggg tttgacccct aattttaaat caaattttga tttggcagaa      780

gatgctaaat tacagctttc aaaagatact tacgatgatg atttagataa tttattggcg      840

caaattggag atcaatatgc tgatttgttt ttggcagcta agaatttatc agatgctatt      900

ttactttcag atatcctaag agtaaatact gaaataacta aggctcccct atcagcttca      960

atgattaaac gctacgatga acatcatcaa gacttgactc ttttaaaagc tttagttcga     1020

caacaacttc cagaaaagta taaagaaatc ttttttgatc aatcaaaaaa cggatatgca     1080

ggttatattg atgggggagc tagccaagaa gaattttata aatttatcaa accaatttta     1140

gaaaaaatgg atggtactga ggaattattg gtgaaactaa atcgtgaaga tttgctgcgc     1200

aagcaacgga cctttgacaa cggctctatt ccccatcaaa ttcacttggg tgagctgcat     1260

gctattttga gaagacaaga agacttttat ccatttttaa aagacaatcg tgagaagatt     1320

gaaaaaatct tgacttttcg aattccttat tatgttggtc cattggcgcg tggcaatagt     1380

cgttttgcat ggatgactcg gaagtctgaa gaaacaatta ccccatggaa ttttgaagaa     1440

gttgtcgata aaggtgcttc agctcaatca tttattgaac gcatgacaaa ctttgataaa     1500

aatcttccaa atgaaaaagt actaccaaaa catagtttgc tttatgagta ttttacggtt     1560

tataacgaat tgacaaaggt caaatatgtt actgaaggaa tgcgaaaacc agcatttctt     1620

tcaggtgaac agaagaaagc cattgttgat ttactcttca aaacaaatcg aaaagtaacc     1680

gttaagcaat taaaagaaga ttatttcaaa aaaatagaat gttttgatag tgttgaaatt     1740

tcaggagttg aagatagatt taatgcttca ttaggtacct accatgattt gctaaaaatt     1800

attaaagata aagatttttt ggataatgaa gaaaatgaag atatcttaga ggatattgtt     1860

ttaacattga ccttatttga agatagggag atgattgagg aaagacttaa aacatatgct     1920

cacctctttg atgataaggt gatgaaacag cttaaacgtc gccgttatac tggttgggga     1980

cgtttgtctc gaaaattgat taatggtatt agggataagc aatctggcaa aacaatatta     2040

gattttttga aatcagatgg ttttgccaat cgcaatttta tgcagctgat ccatgatgat     2100

agtttgacat ttaaagaaga cattcaaaaa gcacaagtgt ctggacaagg cgatagttta     2160

catgaacata ttgcaaattt agctggtagc cctgctatta aaaaaggtat tttacagact     2220

gtaaaagttg ttgatgaatt ggtcaaagta atggggcggc ataagccaga aaatatcgtt     2280

attgaaatgg cacgtgaaaa tcagacaact caaaagggcc agaaaaattc gcgagagcgt     2340

atgaaacgaa tcgaagaagg tatcaaagaa ttaggaagtc agattcttaa agagcatcct     2400

gttgaaaata ctcaattgca aaatgaaaag ctctatctct attatctcca aaatggaaga     2460

gacatgtatg tggaccaaga attagatatt aatcgtttaa gtgattatga tgtcgatcac     2520

attgttccac aaagtttcct taaagacgat tcaatagaca ataaggtctt aacgcgttct     2580

gataaaaatc gtggtaaatc ggataacgtt ccaagtgaag aagtagtcaa aaagatgaaa     2640

aactattgga gacaacttct aaacgccaag ttaatcactc aacgtaagtt tgataattta     2700

acgaaagctg aacgtggagg tttgagtgaa cttgataaag ctggttttat caaacgccaa     2760

ttggttgaaa ctcgccaaat cactaagcat gtggcacaaa ttttggatag tcgcatgaat     2820

actaaatacg atgaaaatga taaacttatt cgagaggtta aagtgattac cttaaaatct     2880

aaattagttt ctgacttccg aaaagatttc caattctata aagtacgtga gattaacaat     2940

taccatcatg cccatgatgc gtatctaaat gccgtcgttg gaactgcttt gattaagaaa     3000

tatccaaaac ttgaatcgga gtttgtctat ggtgattata aagtttatga tgttcgtaaa     3060

atgattgcta agtctgagca agaaataggc aaagcaaccg caaaatattt cttttactct     3120

aatatcatga acttcttcaa aacagaaatt acacttgcaa atggagagat tcgcaaacgc     3180

cctctaatcg aaactaatgg ggaaactgga gaaattgtct gggataaagg gcgagatttt     3240

gccacagtgc gcaaagtatt gtccatgccc caagtcaata ttgtcaagaa aacagaagta     3300

cagacaggcg gattctccaa ggagtcaatt ttaccaaaaa gaaattcgga caagcttatt     3360

gctcgtaaaa aagactggga tccaaaaaaa tatggtggtt ttgatagtcc aacggtagct     3420

tattcagtcc tagtggttgc taaggtggaa aaagggaaat cgaagaagtt aaaatccgtt     3480

aaagagttac tagggatcac aattatggaa agaagttcct ttgaaaaaaa tccgattgac     3540

tttttagaag ctaaaggata taaggaagtt aaaaaagact taatcattaa actacctaaa     3600

tatagtcttt ttgagttaga aaacggtcgt aaacggatgc tggctagtgc cggagaatta     3660

caaaaaggaa atgagctggc tctgccaagc aaatatgtga attttttata tttagctagt     3720

cattatgaaa agttgaaggg tagtccagaa gataacgaac aaaaacaatt gtttgtggag     3780

cagcataagc attatttaga tgagattatt gagcaaatca gtgaattttc taagcgtgtt     3840

attttagcag atgccaattt agataaagtt cttagtgcat ataacaaaca tagagacaaa     3900

ccaatacgtg aacaagcaga aaatattatt catttattta cgttgacgaa tcttggagct     3960

cccgctgctt ttaaatattt tgatacaaca attgatcgta aacgatatac gtctacaaaa     4020

gaagttttag atgccactct tatccatcaa tccatcactg gtctttatga aacacgcatt     4080

gatttgagtc agctaggagg tgactga                                         4107


<210>  11
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  11

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  12
<211>  4131
<212>  DNA
<213>  Streptococcus pyogenes

<400>  12
atggacaaga agtatagcat cgggctggac attggaacga actcggttgg ttgggctgtg       60

attacggacg aatacaaggt gccatccaag aagtttaagg tcctgggaaa caccgaccgt      120

cactcaatca agaagaatct cattggagcc ctgctcttcg atagtgggga gaccgccgaa      180

gctactcgac tgaagcgaac ggctcgccgg cgttatacac gacgcaagaa tcgcatctgc      240

tacctccagg agattttcag caacgaaatg gctaaggttg atgactcatt ctttcatcga      300

ctcgaagaaa gtttcttggt cgaggaggat aagaagcacg agcgccatcc gatctttggt      360

aacattgtgg atgaggttgc ctatcacgaa aagtacccaa ctatctatca tcttcgtaag      420

aagctggtcg atagcacgga caaggctgat ttgcgactta tctacctggc actcgcgcac      480

atgattaagt tccgcggcca ttttcttatc gagggtgacc tgaaccccga taattctgac      540

gttgataagc tcttcatcca gttggtccaa acctacaatc agctgtttga ggaaaaccct      600

attaatgcat ctggcgtgga cgccaaggct atcctttcgg cgcgcctgtc taagtcgcgg      660

cgtttggaga accttatcgc acaactcccc ggcgaaaaga agaacggcct cttcggtaat      720

ttgattgcgt tgtcacttgg tctgactcct aacttcaaga gtaattttga cctggcagag      780

gatgcgaagc tccagttgtc taaggatacg tatgatgacg atctcgacaa cttgcttgcc      840

caaatcggtg accagtacgc tgatcttttc ctggccgcta agaatctctc agatgcaatc      900

ctgctcagtg acattttgcg ggtcaacacc gagattacta aggcccccct gtcagctagt      960

atgatcaagc ggtatgatga gcaccatcag gacctcacct tgcttaaggc cctcgtgcgt     1020

cagcaattgc ctgagaagta caaggaaatc ttctttgacc aatccaagaa cggatacgca     1080

gggtatattg atggcggtgc gagccaggag gaattctaca agtttatcaa gccgattttg     1140

gagaagatgg acggcactga ggaactgctc gtcaagctga atcgcgaaga tttgcttcgt     1200

aagcaacgaa cgttcgacaa cggctccatc ccgcaccaga ttcatctggg cgagctccac     1260

gccatccttc gacgccagga agatttctac ccatttctga aggacaaccg tgagaagatc     1320

gaaaagattc ttacattccg aatcccctac tatgtgggac ctttggcccg tgggaattcc     1380

cgatttgctt ggatgacccg aaagagcgag gaaaccatca ctccgtggaa cttcgaggaa     1440

gtcgtggaca agggtgcatc cgcgcagagc ttcattgagc ggatgaccaa ttttgataag     1500

aaccttccga atgaaaaggt cctgccaaag cattcgctgc tctacgagta tttcaccgtg     1560

tataacgaac tgactaaggt caagtacgtg acggagggaa tgcggaagcc agccttcctc     1620

tcaggggaac aaaagaaggc tatcgtcgat ttgcttttta agaccaatcg taaagtgact     1680

gttaagcagc tgaaggagga ttatttcaag aagattgaat gtttcgactc cgtcgagatc     1740

agcggcgtgg aagatcgctt taacgcttcc ctcggtacct accacgacct gctcaagatc     1800

attaaggaca aggatttcct cgataacgag gaaaatgagg acatcttgga agatattgtc     1860

ctcacgttga cactttttga ggaccgcgaa atgatcgagg aacggctcaa gacatatgcc     1920

catttgttcg acgataaggt gatgaagcag ctgaagcggc gtcgatacac cggatggggt     1980

cgccttagcc ggaagctgat caacggcatt cgagataagc aatctggtaa gactatcttg     2040

gatttcctta agtcggacgg cttcgccaac cgcaatttta tgcagcttat tcacgacgat     2100

tccctgacgt tcaaggagga catccagaag gcacaagtct caggacaagg ggattccctg     2160

cacgagcata tcgccaacct ggctggatcc ccggcgatca agaaggggat tcttcagacc     2220

gtcaaggttg tcgacgagct ggtcaaggtg atgggccgtc ataagccaga aaacatcgtg     2280

attgagatgg cccgagaaaa tcagaccact caaaagggtc agaagaacag ccgcgagcgg     2340

atgaagcgga tcgaggaagg cattaaggaa cttggttctc agatcctgaa ggagcaccct     2400

gttgaaaaca cacagctcca aaatgagaag ctgtatctct actatttgca aaatggacgc     2460

gacatgtacg tcgatcagga gctcgacatt aaccggttgt cggactacga tgttgaccat     2520

atcgtcccgc aatccttcct taaggacgat agcattgata acaaggtgct gactcgctca     2580

gataagaacc ggggcaagtc cgacaatgtt ccaagcgagg aagtggttaa gaagatgaag     2640

aactactggc gccaattgct taatgccaag ctcatcacac agcgcaagtt tgacaacttg     2700

accaaggccg agcggggagg gctgagtgaa ctcgataagg ctggcttcat caagcgtcaa     2760

ctcgtggaga cgcgacagat cacaaagcac gttgctcaga ttctggactc ccggatgaac     2820

acaaagtacg acgagaatga taagctcatc cgtgaagtta aggtcattac cctcaagtct     2880

aagttggtgt cggatttccg caaggacttc caattttata aggttcggga gatcaacaat     2940

tatcaccatg cacatgatgc gtacctcaac gcagtcgtgg gaactgcgct catcaagaag     3000

tatcccaagt tggagtccga attcgtctac ggggattata aggtttacga cgtccgcaag     3060

atgatcgcca agagtgagca ggaaattggc aaggccacgg ctaagtattt cttttactcc     3120

aacatcatga atttctttaa gacggagatc acactcgcca atggagaaat ccgtaagcga     3180

cctttgattg agaccaacgg cgagactggt gaaatcgttt gggataaggg gcgcgacttc     3240

gctaccgtgc ggaaggttct gagcatgccg caagtcaata tcgtcaagaa aaccgaggtg     3300

cagacaggcg gtttctctaa ggaatcgatt cttccaaagc gtaactctga caagctgatc     3360

gctcgaaaga aggattggga ccccaagaag tatggagggt tcgattctcc tacagtggca     3420

tactcggttc tcgttgtcgc gaaggttgag aagggaaagt ctaagaagct gaagtcggtc     3480

aaggaactgc tcgggatcac cattatggag cgctccagct tcgaaaagaa tcccatcgac     3540

tttctcgagg ccaagggcta taaggaagtc aagaaggatc ttatcattaa gctgcctaag     3600

tactctttgt tcgagcttga aaacggtcga aagcgaatgc tcgcatcggc aggagagttg     3660

cagaagggga atgaattggc acttccctca aagtacgtga acttcctgta tctcgcgtcc     3720

cactacgaga agctgaaggg tagccctgag gacaacgaac agaagcaact ttttgttgag     3780

caacacaagc attatctgga tgagatcatt gaacagattt cagagttcag taagcgcgtc     3840

atcctcgccg atgctaatct cgacaaggtg ttgtcggcct acaacaagca ccgtgacaag     3900

ccgatccgag agcaggctga aaatatcatt catctgttca ccctcactaa cttgggagca     3960

ccagcagcgt tcaagtattt tgatacgaca atcgaccgta agcgatacac gtccacaaag     4020

gaggtgcttg atgcgaccct gattcatcaa tccatcactg ggctctatga aacccgtatc     4080

gaccttagtc aactgggggg cgaccccccc aagaagaagc gcaaggtctg a              4131


<210>  13
<211>  500
<212>  DNA
<213>  Magnaporthe oryzae

<400>  13
tctgctcgag gccatctggc ttttctctgc tgtctgcctc gggaatggga tggaatacca       60

cgtacggtat ttggcctccg gtgccatccg aagcgagatg ctttgagctt gaaaccccct      120

cggcctgcac aggtgtctca tcgtgcattt aatccaacgg cggcgagtca aaacatcagc      180

taattgacca ggtttctgga ttgtgaatgc caactttttg ggtcttgagg agttgcgggg      240

tgggaaaaaa gtaaagaaat ttactgagga ttttatcatt gcgactataa aataaagcgg      300

cattgcaaat ccttgcgttg ctactatgta aaatggactg tagttgtgct gctgaaaata      360

gtttggcgat tgtggattgt ggattgtgga ttgtggatta tggcaagttg tcaaggggca      420

agttgacgaa aatgattgtg tggtgtctgc cagcaaattg agaacgtggg tatatatttc      480

atcttttcat gattcccttc                                                  500


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  20 bp protospacer region targeting the T. reesei wA gene

<400>  14
gctggatgag aataccctcg                                                   20


<210>  15
<211>  78
<212>  DNA
<213>  Streptococcus pyogenes

<400>  15
gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt       60

ggcaccgagt cggtgctt                                                     78


<210>  16
<211>  300
<212>  DNA
<213>  Aspergillus fumigatus

<400>  16
ttttttacac acctacagac ctcatttgga ggttcgagtg tcagccaggt tgatgagcat       60

cgtaagtgcg gtcgttcgaa acggactgcc atcgcacttt ctttttgcac tgtatcaact      120

tcacaagtct acctacaagg ctgtaacaca acgccacact tgtgcagaaa ccatgagaat      180

cattttacaa cacaggaata actcgtctat aatatgcatc ctgattcaga aactataaat      240

acacgaatat gagatttctg atttactctg cagtttcaac tttgagcata tgccctaagc      300


<210>  17
<211>  665
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSMai274 String DNA fragment

<400>  17
attgcctgca ggcatgcaag cttgcggccg ctctgctcga ggccatctgg cttttctctg       60

ctgtctgcct cgggaatggg atggaatacc acgtacggta tttggcctcc ggtgccatcc      120

gaagcgagat gctttgagct tgaaaccccc tcggcctgca caggtgtctc atcgtgcatt      180

taatccaacg gcggcgagtc aaaacatcag ctaattgacc aggtttctgg attgtgaatg      240

ccaacttttt gggtcttgag gagttgcggg gtgggaaaaa agtaaagaaa tttactgagg      300

attttatcat tgcgactata aaataaagcg gcattgcaaa tccttgcgtt gctactatgt      360

aaaatggact gtagttgtgc tgctgaaaat agtttggcga ttgtggattg tggattgtgg      420

attgtggatt atggcaagtt gtcaaggggc aagttgacga aaatgattgt gtggtgtctg      480

ccagcaaatt gagaacgtgg gtatatattt catcttttca tgattccctt cgctggatga      540

gaataccctc ggttttagag ctagaaatag caagttaaaa taaggctagt ccgttatcaa      600

cttgaaaaag tggcaccgag tcggtgcttt ttttgcggcc gcaagcttcg agacagcaga      660

atcac                                                                  665


<210>  18
<211>  215
<212>  DNA
<213>  Magnaporthe oryzae

<400>  18
tttttttggc tcttgggttc gaactgccca aggcccatgt tttggtcatc ttttttttta       60

tgccccacca tttgggtcac ccctgccaat cattccatct ttgttcctac ccttcacgtg      120

tgctttccga agccaaagtt cccattcaac aactctcctt gcgttttttt tttcttgaag      180

cttgtcaccc gtcgatagtt tctgccattt gcaat                                 215


<210>  19
<211>  253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSMai280 String DNA fragment

<400>  19
caccgagtcg gtgctttttt tttggctctt gggttcgaac tgcccaaggc ccatgttttg       60

gtcatctttt tttttatgcc ccaccatttg ggtcacccct gccaatcatt ccatctttgt      120

tcctaccctt cacgtgtgct ttccgaagcc aaagttccca ttcaacaact ctccttgcgt      180

tttttttttc ttgaagcttg tcacccgtcg atagtttctg ccatttgcaa taagcttcga      240

gacagcagaa tca                                                         253


<210>  20
<211>  500
<212>  DNA
<213>  Aspergillus fumigatus

<400>  20
taagcaaagt tcaacttcaa tcaaactcaa tcaaactaga ttctcaactt cggtacacct       60

gaaaaccctt cagctccttc acagggtcct gaatcatatt cgcgagttgt caccaggcat      120

cagtcacatc tggagagaaa actgaaaggg tctcgtggat caatagtgaa catctgcctg      180

catttctcct ttcgctacct ttggcttttt ctttttgtgg cttggatgat cccgctcata      240

gtgctctcca acatccaatg gctctccaag tcatggcggc ctgagatcaa ctgcgtaata      300

tctccatttt tggaggacca catagcctta taacacttac cagggttcac cttgaaatgt      360

ttcatccctc gatctgagtc gtttcgaatt ctgtcacgtt cctgcacaga ggtaagattt      420

gatgttcctc tcactaccgc ttaccgacca atcatatcgt ccaatagcca ttcactgaaa      480

tgcatataaa ccattctaat                                                  500


<210>  21
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pJfyS238 String DNA fragment

<400>  21
tattgcctgc aggcatgcaa gctttaagca aagttcaact tcaatcaaac tcaatcaaac       60

tagattctca acttcggtac acctgaaaac ccttcagctc cttcacaggg tcctgaatca      120

tattcgcgag ttgtcaccag gcatcagtca catctggaga gaaaactgaa agggtctcgt      180

ggatcaatag tgaacatctg cctgcatttc tcctttcgct acctttggct ttttcttttt      240

gtggcttgga tgatcccgct catagtgctc tccaacatcc aatggctctc caagtcatgg      300

cggcctgaga tcaactgcgt aatatctcca tttttggagg accacatagc cttataacac      360

ttaccagggt tcaccttgaa atgtttcatc cctcgatctg agtcgtttcg aattctgtca      420

cgttcctgca cagaggtaag atttgatgtt cctctcacta ccgcttaccg accaatcata      480

tcgtccaata gccattcact gaaatgcata taaaccattc taatgctgga tgagaatacc      540

ctcggtttta gagctagaaa tagcaagtta aaataaggct agtccgttat caacttgaaa      600

aagtggcacc gagtcggtgc tttttttaag cttcgagaca gcagaatcac c               651


<210>  22
<211>  111
<212>  DNA
<213>  Aspergillus fumigatus

<400>  22
ggcttgcttg tcaagcaatg gcatcattgg tctagtggta gaattcgtcg ttgccatcga       60

cgaggcccgt gttcgattca cggatgatgc attcattgtt gatgcatatc t               111


<210>  23
<211>  742
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pJfyS242 String DNA fragment

<400>  23
tattgcctgc aggcatgcaa gctttaagca aagttcaact tcaatcaaac tcaatcaaac       60

tagattctca acttcggtac acctgaaaac ccttcagctc cttcacaggg tcctgaatca      120

tattcgcgag ttgtcaccag gcatcagtca catctggaga gaaaactgaa agggtctcgt      180

ggatcaatag tgaacatctg cctgcatttc tcctttcgct acctttggct ttttcttttt      240

gtggcttgga tgatcccgct catagtgctc tccaacatcc aatggctctc caagtcatgg      300

cggcctgaga tcaactgcgt aatatctcca tttttggagg accacatagc cttataacac      360

ttaccagggt tcaccttgaa atgtttcatc cctcgatctg agtcgtttcg aattctgtca      420

cgttcctgca cagaggtaag atttgatgtt cctctcacta ccgcttaccg accaatcata      480

tcgtccaata gccattcact gaaatgcata taaaccattc taatggcttg cttgtcaagc      540

aatggcatca ttggtctagt ggtagaattc gtcgttgcca tcgacgaggc ccgtgttcga      600

ttcacggatg atgcagctgg atgagaatac cctcggtttt agagctagaa atagcaagtt      660

aaaataaggc tagtccgtta tcaacttgaa aaagtggcac cgagtcggtg ctttttttaa      720

gcttcgagac agcagaatca cc                                               742


<210>  24
<211>  480
<212>  DNA
<213>  Aspergillus fumigatus

<400>  24
tctaaattat atattacaga catcgcagtc tactgaccaa cccgtaatcg agccttgcca       60

tcagtgatac tagagaaaca tagtaaacaa cacatcttgt cgtcattgaa acgactttct      120

ccattgcgat cagtgccggg acgatcccag accccgagtc tgtccccttg caccggctct      180

aggagcagac agtccgggat atgacggcca cgccaaatgt ggttcgtgac tatacaccgg      240

tatcgtgtcc ttcgctgaga agaatcaata gagcgtgctt ccttgagccc agactcaact      300

cagatactac cattcgaaat cggcgcgttg tcgtgttctg atagctggca gagctgaatg      360

ccattgctgg tgttctcgta gccgtcatgt tccggtagtc caatacaagg aaaacagtta      420

aggtggtagc aaatagatgg tcagtgccac tagcttagat tagctcctat agcgtcagaa      480


<210>  25
<211>  111
<212>  DNA
<213>  Aspergillus fumigatus

<400>  25
tgagaaggag tcaacaatca ggtgctgtgg tctagtggta ggacgtcacg ttgtggccgt       60

gccagccccg gttcgattcc gggcagcacc acaaattcca ggctctttcc t               111


<210>  26
<211>  718
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pJfyS254 String DNA fragment

<400>  26
ttgcctgcag gcatgcaagc tttctaaatt atatattaca gacatcgcag tctactgacc       60

aacccgtaat cgagccttgc catcagtgat actagagaaa catagtaaac aacacatctt      120

gtcgtcattg aaacgacttt ctccattgcg atcagtgccg ggacgatccc agaccccgag      180

tctgtcccct tgcaccggct ctaggagcag acagtccggg atatgacggc cacgccaaat      240

gtggttcgtg actatacacc ggtatcgtgt ccttcgctga gaagaatcaa tagagcgtgc      300

ttccttgagc ccagactcaa ctcagatact accattcgaa atcggcgcgt tgtcgtgttc      360

tgatagctgg cagagctgaa tgccattgct ggtgttctcg tagccgtcat gttccggtag      420

tccaatacaa ggaaaacagt taaggtggta gcaaatagat ggtcagtgcc actagcttag      480

attagctcct atagcgtcag aatgagaagg agtcaacaat caggtgctgt ggtctagtgg      540

taggacgtca cgttgtggcc gtgccagccc cggttcgatt ccgggcagca ccagctggat      600

gagaataccc tcggttttag agctagaaat agcaagttaa aataaggcta gtccgttatc      660

aacttgaaaa agtggcaccg agtcggtgct ttttttaagc ttcgagacag cagaatca        718


<210>  27
<211>  500
<212>  DNA
<213>  Aspergillus fumigatus

<400>  27
gcctttggct ttgcgacttt accgcattgg gattctgggg gattccgttg cgttttgtgg       60

ggagctgatg atgactaagc aaacaacaac cattgcactg gaacagatgc gatgcgtgtg      120

ctaactgaaa ggatagccct ggtctgacct cctgaatcct gactatctgc cactatcagg      180

attcctgcaa aagaggagta cctttcatgc tcggcaactg caaaagcaga atgtactgtt      240

cgagatagtt gcaccttcct aatctgaccc ttcccaaaca gggaacctca gatcgcttct      300

tcgaatggag tgtaggcaga tcatactcca tcatcaatcc tcctgtcgct gcgtcgtgct      360

acttgaagca tgaagtagaa ttcccaccga caatgtgtga cagggtatat tgatgttctc      420

gccatcgctt gacgagccaa tcacagtgca gagagtttac aaaggtttgg catatgagtc      480

actttcactt tccaagaagt                                                  500


<210>  28
<211>  209
<212>  DNA
<213>  Aspergillus fumigatus

<400>  28
tttttttttc attcttacag acctcttttg gaggtgttga gtttctgtac cttctacgtg       60

tgtgcgaaag gtcgtcggtt cgagaccgga ccgagtgtct tttttgtctt cttttcccct      120

ccttgctctc gagcttaacc ttcgaaactc tgacaagctg tacagagaaa tgttcaaaga      180

ttacatgtct catcgtaaca tcgctctct                                        209


<210>  29
<211>  852
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pJfyS244 String DNA fragment

<400>  29
ttgcctgcag gcatgcaagc ttgcctttgg ctttgcgact ttaccgcatt gggattctgg       60

gggattccgt tgcgttttgt ggggagctga tgatgactaa gcaaacaaca accattgcac      120

tggaacagat gcgatgcgtg tgctaactga aaggatagcc ctggtctgac ctcctgaatc      180

ctgactatct gccactatca ggattcctgc aaaagaggag tacctttcat gctcggcaac      240

tgcaaaagca gaatgtactg ttcgagatag ttgcaccttc ctaatctgac ccttcccaaa      300

cagggaacct cagatcgctt cttcgaatgg agtgtaggca gatcatactc catcatcaat      360

cctcctgtcg ctgcgtcgtg ctacttgaag catgaagtag aattcccacc gacaatgtgt      420

gacagggtat attgatgttc tcgccatcgc ttgacgagcc aatcacagtg cagagagttt      480

acaaaggttt ggcatatgag tcactttcac tttccaagaa gtgctggatg agaataccct      540

cggttttaga gctagaaata gcaagttaaa ataaggctag tccgttatca acttgaaaaa      600

gtggcaccga gtcggtgctt tttttttttc attcttacag acctcttttg gaggtgttga      660

gtttctgtac cttctacgtg tgtgcgaaag gtcgtcggtt cgagaccgga ccgagtgtct      720

tttttgtctt cttttcccct ccttgctctc gagcttaacc ttcgaaactc tgacaagctg      780

tacagagaaa tgttcaaaga ttacatgtct catcgtaaca tcgctctcta agcttcgaga      840

cagcagaatc ac                                                          852


<210>  30
<211>  500
<212>  DNA
<213>  Aspergillus fumigatus

<400>  30
aaccggagag tactatcaac cgagcgcctg gtttttacct ttcaatctcg accctgtcgg       60

tgcaggtgtc ggtcttgatc ccaaccctgc ggcttccgtg cccagtagcg aaaatgccac      120

tccagactta tccgcgtttg gcggtactgg cataccactg ggagggtatg atctgggaat      180

gacgggaatg aatcaaaggt cccatcggtg atgggtattg ctcctttttt tttttttttt      240

tttttttttt tctctctttg cgagcggttc tggttgggcg aatatggtgt cttggaaaag      300

ggtggggggt tcacgacttc tatatgctct gtatgctgaa ctgtttgtgt aactgagttg      360

tatatccctg ctttactccg tactctgatc cattactttc tttgtctgtg tcgtctaatc      420

tcgttgccat actgacccgc ttaccgacca atcatgccac tggaaattcc tttatagttc      480

attctaatgt cttcacaagt                                                  500


<210>  31
<211>  209
<212>  DNA
<213>  Aspergillus fumigatus

<400>  31
tttttttttg agcgcttaca ggccacattt ttaggtaaga tgtcagccat gttgatgggg       60

cattgcgagt agcggtcgtt cgaaacaaga tggagtctgg tcaggcatgg aagcaaaagt      120

catggcgaga atatgtatgt cctcctttga gatcggaata tcgtggtcac atgttcaagc      180

gtaatggtac tgtaggatcc agaaaaaaa                                        209


<210>  32
<211>  852
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pJfyS245 String DNA fragment

<400>  32
ttgcctgcag gcatgcaagc ttaaccggag agtactatca accgagcgcc tggtttttac       60

ctttcaatct cgaccctgtc ggtgcaggtg tcggtcttga tcccaaccct gcggcttccg      120

tgcccagtag cgaaaatgcc actccagact tatccgcgtt tggcggtact ggcataccac      180

tgggagggta tgatctggga atgacgggaa tgaatcaaag gtcccatcgg tgatgggtat      240

tgctcctttt tttttttttt tttttttttt tttctctctt tgcgagcggt tctggttggg      300

cgaatatggt gtcttggaaa agggtggggg gttcacgact tctatatgct ctgtatgctg      360

aactgtttgt gtaactgagt tgtatatccc tgctttactc cgtactctga tccattactt      420

tctttgtctg tgtcgtctaa tctcgttgcc atactgaccc gcttaccgac caatcatgcc      480

actggaaatt cctttatagt tcattctaat gtcttcacaa gtgctggatg agaataccct      540

cggttttaga gctagaaata gcaagttaaa ataaggctag tccgttatca acttgaaaaa      600

gtggcaccga gtcggtgctt tttttttttg agcgcttaca ggccacattt ttaggtaaga      660

tgtcagccat gttgatgggg cattgcgagt agcggtcgtt cgaaacaaga tggagtctgg      720

tcaggcatgg aagcaaaagt catggcgaga atatgtatgt cctcctttga gatcggaata      780

tcgtggtcac atgttcaagc gtaatggtac tgtaggatcc agaaaaaaaa agcttcgaga      840

cagcagaatc ac                                                          852


<210>  33
<211>  508
<212>  DNA
<213>  Aspergillus oryzae

<400>  33
tggttcactt ctctttagaa atcaactgtg ggttttgctt tttgcttcat tctctttgtc       60

ttctccatct ttgatcaaat cctggacttt ctcaatcccc agctaattca atcatagtca      120

gttttctatt tttattattt ctttttcttt tgaaatgtga ttaacaacca gtccgttata      180

tatcttgtac ccagattacg cccaactcgt gctcctcagc cacaaagata ctcaattgat      240

agccaagata catacatacc acaaagtaag gactccatgc attgagtatt actcatcgta      300

ttctagacta ctccaaaact cagcacatag acaaacaata cgaacctcgt ctaggggtga      360

ttcagaggcg gcaaagcggg gttttcgcat ttgatgttcc tggcacttat gtaagcccac      420

gcttcccgct caactaaacc atcagccaat cagactgctc agatttatct tttgaagggt      480

aaataaatca ttgtaaagaa gaacaagt                                         508


<210>  34
<211>  138
<212>  DNA
<213>  Aspergillus oryzae

<400>  34
tttttttttg agcatttatc agcttgatat agaggtagga atgtatggag gtgcagaatg       60

gctattttgt tattggagcg ggttcgaaac ggagggcagg agactttttc taaatacgtc      120

acgtgatata gagctgct                                                    138


<210>  35
<211>  789
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pJfyS247 String DNA fragment

<400>  35
ttgcctgcag gcatgcaagc tttggttcac ttctctttag aaatcaactg tgggttttgc       60

tttttgcttc attctctttg tcttctccat ctttgatcaa atcctggact ttctcaatcc      120

ccagctaatt caatcatagt cagttttcta tttttattat ttctttttct tttgaaatgt      180

gattaacaac cagtccgtta tatatcttgt acccagatta cgcccaactc gtgctcctca      240

gccacaaaga tactcaattg atagccaaga tacatacata ccacaaagta aggactccat      300

gcattgagta ttactcatcg tattctagac tactccaaaa ctcagcacat agacaaacaa      360

tacgaacctc gtctaggggt gattcagagg cggcaaagcg gggttttcgc atttgatgtt      420

cctggcactt atgtaagccc acgcttcccg ctcaactaaa ccatcagcca atcagactgc      480

tcagatttat cttttgaagg gtaaataaat cattgtaaag aagaacaagt gctggatgag      540

aataccctcg gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac      600

ttgaaaaagt ggcaccgagt cggtgctttt tttttttgag catttatcag cttgatatag      660

aggtaggaat gtatggaggt gcagaatggc tattttgtta ttggagcggg ttcgaaacgg      720

agggcaggag actttttcta aatacgtcac gtgatataga gctgctaagc ttcgagacag      780

cagaatcac                                                              789


<210>  36
<211>  106
<212>  DNA
<213>  Homo sapiens

<400>  36
gtgctcgctt cggcagcaca tatactaaaa ttggaacgat acagagaaga ttagcatggc       60

ccctgcgcaa ggatgacacg caaattcgtg aagcgttcca tatttt                     106


<210>  37
<211>  177
<212>  DNA
<213>  Trichoderma reesei

<400>  37
tatagtaata aaagcttagc agctgtaata taattcctaa agaaacagca tgaaatggta       60

ttatgtaaga gctatagtct aaaggcactc tgctggataa aaatagtggc tataagtctg      120

ctgcaaaact acccccaacc tcgtaggtat ataagtactg tttgatggta gtctatc         177


<210>  38
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  38
cctgcaggca tgcaagcttt atagtaataa aagcttagc                              39


<210>  39
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  39
ggtattctca tccagcgata gactaccatc aaacag                                 36


<210>  40
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  40
ttgatggtag tctatcgctg gatgagaata ccctcg                                 36


<210>  41
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  41
tggaagagaa aaaaaaaagc accgactcgg tgccac                                 36


<210>  42
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  42
caccgagtcg gtgctttttt ttttctcttc caagtcgtg                              39


<210>  43
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  43
tgattctgct gtctcgaagc ttcgaagacg ggctgccgag ga                          42


<210>  44
<211>  91
<212>  DNA
<213>  Trichoderma reesei

<400>  44
ggcttgcttg tcaagcaatg gcatcattgg tctagtggta gaattcgtcg ttgccatcga       60

cgaggcccgt gttcgattca cggatgatgc a                                      91


<210>  45
<211>  716
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pJfyS249 String DNA fragment

<400>  45
tgcctgcagg catgcaagct ttatagtaat aaaagcttag cagctgtaat ataattccta       60

aagaaacagc atgaaatggt attatgtaag agctatagtc taaaggcact ctgctggata      120

aaaatagtgg ctataagtct gctgcaaaac tacccccaac ctcgtaggta tataagtact      180

gtttgatggt agtctatcgg cttgcttgtc aagcaatggc atcattggtc tagtggtaga      240

attcgtcgtt gccatcgacg aggcccgtgt tcgattcacg gatgatgcag ctggatgaga      300

ataccctcgg ttttagagct agaaatagca agttaaaata aggctagtcc gttatcaact      360

tgaaaaagtg gcaccgagtc ggtgcttttt tttttctctt ccaagtcgtg atggttatct      420

ttttgcttag agaatctatt cttgtggacg attagtattg gtaaatccct gctgcacatt      480

gcggcggatg gtctcaacgg cataataccc cattcgtgat gcagcggtga tcttcaatat      540

gtagtgtaat acgttgcata caccaccagg ttcggtgcct cctgtatgta cagtactgta      600

gttcgactcc tccgcgcagg tggaaacgat tccctagtgg gcaggtattt tggcggggtc      660

aagaatccga cccctcctcg gcagcccgtc ttcgaagctt cgagacagca gaatcc          716


<210>  46
<211>  877
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pJfyS250 String DNA fragment

<400>  46
tgcctgcagg catgcaagct ttggttcact tctctttaga aatcaactgt gggttttgct       60

ttttgcttca ttctctttgt cttctccatc tttgatcaaa tcctggactt tctcaatccc      120

cagctaattc aatcatagtc agttttctat ttttattatt tctttttctt ttgaaatgtg      180

attaacaacc agtccgttat atatcttgta cccagattac gcccaactcg tgctcctcag      240

ccacaaagat actcaattga tagccaagat acatacatac cacaaagtaa ggactccatg      300

cattgagtat tactcatcgt attctagact actccaaaac tcagcacata gacaaacaat      360

acgaacctcg tctaggggtg attcagaggc ggcaaagcgg ggttttcgca tttgatgttc      420

ctggcactta tgtaagccca cgcttcccgc tcaactaaac catcagccaa tcagactgct      480

cagatttatc ttttgaaggg taaataaatc attgtaaaga agaacaagtg gcttgcttgt      540

caagcaatgg catcattggt ctagtggtag aattcgtcgt tgccatcgac gaggcccgtg      600

ttcgattcac ggatgatgca gctggatgag aataccctcg gttttagagc tagaaatagc      660

aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt      720

tttttttgag catttatcag cttgatatag aggtaggaat gtatggaggt gcagaatggc      780

tattttgtta ttggagcggg ttcgaaacgg agggcaggag actttttcta aatacgtcac      840

gtgatataga gctgctaagc ttcgagacag cagaatc                               877


<210>  47
<211>  754
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pJfyS251 String DNA fragment

<400>  47
ttgcctgcag gcatgcaagc ttgcggccgc tctgctcgag gccatctggc ttttctctgc       60

tgtctgcctc gggaatggga tggaatacca cgtacggtat ttggcctccg gtgccatccg      120

aagcgagatg ctttgagctt gaaaccccct cggcctgcac aggtgtctca tcgtgcattt      180

aatccaacgg cggcgagtca aaacatcagc taattgacca ggtttctgga ttgtgaatgc      240

caactttttg ggtcttgagg agttgcgggg tgggaaaaaa gtaaagaaat ttactgagga      300

ttttatcatt gcgactataa aataaagcgg cattgcaaat ccttgcgttg ctactatgta      360

aaatggactg tagttgtgct gctgaaaata gtttggcgat tgtggattgt ggattgtgga      420

ttgtggatta tggcaagttg tcaaggggca agttgacgaa aatgattgtg tggtgtctgc      480

cagcaaattg agaacgtggg tatatatttc atcttttcat gattcccttc ggcttgcttg      540

tcaagcaatg gcatcattgg tctagtggta gaattcgtcg ttgccatcga cgaggcccgt      600

gttcgattca cggatgatgc agctggatga gaataccctc ggttttagag ctagaaatag      660

caagttaaaa taaggctagt ccgttatcaa cttgaaaaag tggcaccgag tcggtgcttt      720

ttttgcggcc gcaagcttcg agacagcaga atca                                  754


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  48
agatgaatat tgcctgcagg                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  49
tgattctgct gtctcgaagc                                                   20


<210>  50
<211>  940
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pJfyS253 String DNA fragment

<400>  50
tgcctgcagg catgcaagct taaccggaga gtactatcaa ccgagcgcct ggtttttacc       60

tttcaatctc gaccctgtcg gtgcaggtgt cggtcttgat cccaaccctg cggcttccgt      120

gcccagtagc gaaaatgcca ctccagactt atccgcgttt ggcggtactg gcataccact      180

gggagggtat gatctgggaa tgacgggaat gaatcaaagg tcccatcggt gatgggtatt      240

gctccttttt tttttttttt tttttttttt ttctctcttt gcgagcggtt ctggttgggc      300

gaatatggtg tcttggaaaa gggtgggggg ttcacgactt ctatatgctc tgtatgctga      360

actgtttgtg taactgagtt gtatatccct gctttactcc gtactctgat ccattacttt      420

ctttgtctgt gtcgtctaat ctcgttgcca tactgacccg cttaccgacc aatcatgcca      480

ctggaaattc ctttatagtt cattctaatg tcttcacaag tggcttgctt gtcaagcaat      540

ggcatcattg gtctagtggt agaattcgtc gttgccatcg acgaggcccg tgttcgattc      600

acggatgatg cagctggatg agaataccct cggttttaga gctagaaata gcaagttaaa      660

ataaggctag tccgttatca acttgaaaaa gtggcaccga gtcggtgctt tttttttttg      720

agcgcttaca ggccacattt ttaggtaaga tgtcagccat gttgatgggg cattgcgagt      780

agcggtcgtt cgaaacaaga tggagtctgg tcaggcatgg aagcaaaagt catggcgaga      840

atatgtatgt cctcctttga gatcggaata tcgtggtcac atgttcaagc gtaatggtac      900

tgtaggatcc agaaaaaaaa agcttcgaga cagcagaatc                            940


<210>  51
<211>  4038
<212>  DNA
<213>  Streptococcus mutans

<400>  51
atgaaaaaac cttactctat tggacttgat attggaacca attctgttgg ttgggctgtt       60

gtgacagatg actacaaggt tcctgctaag aagatgaagg ttctgggaaa tacagataaa      120

agtcatatca agaaaaattt gcttggcgct ttattatttg atagcgggaa tactgcagaa      180

gacagacggt taaagagaac tgctcgccgt cgttacacac gtcgcagaaa tcgtatttta      240

tatttgcaag agattttttc agaagaaatg ggcaaggtag atgatagttt ctttcatcgt      300

ttagaggatt cttttcttgt tactgaggat aaacgaggag agtgccatcc catttttggg      360

aatcttgaag aagaagttaa gtatcatgaa aattttccaa ccatttatca tttgcggcaa      420

tatcttgcgg ataatccaga aaagactgat ttacgtttag tttatttggc tttagcacat      480

ataattaagt ttagaggtca ttttttaatt gaaggaaagt ttgatacacg caataatgat      540

gtacaaagac tgtttcaaga atttttagca gtctatgata atacttttga gaatagttcg      600

cttcaggagc aaaatgttca agttgaggaa attctgactg ataaaatcag taaatctgct      660

aagaaagata gagttttgaa actttttcct aatgaaaagt ctaatggccg ctttgcagaa      720

tttctaaaac taattgttgg taatcaagct gattttaaaa agcattttga attagaagag      780

aaagcaccat tgcaattttc taaagatact tatgaagaag agttagaagt actattagct      840

caaattggag ataattacgc agagctcttt ttatcagcaa agaaactgta tgatagtatc      900

cttttatcag ggattttaac agttactgat gttagtacca aagcgccttt atctgcttcg      960

atgattcagc gatataatga acatcagatg gatttaactc agcttaaaca attcattcgt     1020

cagaaattat cagataaata taacgaagtt ttttctgatg tttcaaaaga cggctatgcg     1080

ggttatattg atgggaaaac aaatcaagaa gctttttata aataccttaa aggtctatta     1140

aataagattg agggaaatgg ctatttcctt gataaaattg agcgtgaaga ttttctaaga     1200

aagcaacgta cctttgacaa tggctctatt ccacatcaga ttcatcttca agaaatgcgt     1260

gctatcattc gtagacaggc tgaattttat ccgtttttag cagacaatca agataggatt     1320

gagaaaatat tgactttccg tattccctac tatgttggtc cattagcgcg cggaaaaagt     1380

gattttgctt ggttaagtcg gaaatcggct gataaaatta caccatggaa ttttgatgaa     1440

atcgttgata aagaatcctc tgcagaagct tttatcaatc gtatgacaaa ttatgatttg     1500

tacttaccaa atcaaaaagt tcttcctaaa catagtttat tatacgaaaa atttactgtt     1560

tacaatgaat taacaaaggt taaatataaa acagagcaag gaaaaacagc attttttgat     1620

gccaatatga agcaagaaat ctttgatggc gtatttaagg tttatcgaaa agtaactaaa     1680

gataaattaa tggatttcct tgaaaaagaa tttgatgaat ttcgtattgt tgatttaaca     1740

ggtctggata aagaaaataa agcatttaac gcttcttatg gaacttatca tgatttgcgt     1800

aaaattttag ataaagattt tctcgataat tcaaagaatg aaaagatttt agaagatatt     1860

gtgttgacct taacgttatt tgaagataga gaaatgatta gaaaacgtct agaaaattac     1920

agtgatttat tgactaaaga acaagtgaaa aaactggaaa gacgtcatta tactggttgg     1980

ggaagattat cagctgagtt aattcatggt attcgcaaca aagaaagcag aaaaacactt     2040

cttgattatc tcattgatga tggcaatagc aatcgtaact ttatgcaact gattaacgat     2100

gatgctcttt ctttcaaaga agagattgct aaggcacaag ttattggaga aacagacaat     2160

ctaaatcaag ttgttagtga tattgctggt agccctgcta ttaaaaaagg aattttacaa     2220

agcttgaaga ttgttgatga gcttgtcaaa attatgggac atcaacctga aaatatcgtc     2280

gtggagatgg cgcgtgaaaa ccagtttacc aatcagggac ggcgaaattc acagcaacgt     2340

ttgaaaggtt tgacagattc tattaaagaa tttggaagtc aaattcttaa agaacatccg     2400

gttgagaatt cacagttaca aaatgataga ttgtttctat attatttaca aaacggcaga     2460

gatatgtata ctggagaaga attggatatt gattatctaa gccagtatga tatagaccat     2520

attatcccgc aagcttttat aaaggataat tctattgata atagagtatt gactagttca     2580

aaggaaaatc gtggaaaatc ggatgatgta ccaagtaaag atgttgttcg taaaatgaaa     2640

ccctattgga gtaagctact ttcggcaaag cttattacac aacgtaaatt tgataatttg     2700

acaaaagctg aacgaggtgg attgaccgac gatgataaag ctggattcat caagcgtcaa     2760

ttagtagaaa cacgacaaat taccaaacat gtagcacgta ttctggatga acgatttaat     2820

acagaaacag atgaaaacaa caagaaaatt cgtcaagtaa aaattgtgac cttgaaatca     2880

aatcttgttt ccaatttccg taaagagttt gaactctaca aagtgcgtga aattaatgac     2940

tatcatcatg cacatgatgc ctatctcaat gctgtaattg gaaaggcttt actaggtgtt     3000

tacccacaat tggaacctga atttgtttat ggggattatc ctcattttca tggacatgaa     3060

gaaaataaag caactgctaa gaaatttttc tattcaaata ttatgaactt ctttaaaaaa     3120

gatgatgtcc gtactgataa aaatggtgaa attatctgga aaaaagatga gcatatttct     3180

aatattaaaa aagtgctttc ttatccacaa gtcaatattg ttaagaaagt ggaggaacaa     3240

acgggaggat tttctaaaga atctatcttg ccgaaaggta attctgacaa gcttattcct     3300

cgaaaaacga agaaatttta ttgggatacc aagaaatatg gaggatttga tagcccgatt     3360

gttgcttatt ctattttagt tattgctgat attgaaaaag gtaaatctaa aaaattgaaa     3420

acagtcaaag ccttagttgg tgtcactatt atggaaaaga tgacttttga aagggatcca     3480

gttgcttttc ttgagcgaaa aggctatcga aatgttcaag aagaaaatat tataaagtta     3540

ccaaaatata gtttatttaa actagaaaac ggacgaaaaa ggctattggc aagtgctagg     3600

gaacttcaaa agggaaatga aatcgttttg ccaaatcatt taggaacctt gctttatcac     3660

gctaaaaata ttcataaagt tgatgaacca aagcatttgg actatgttga taaacataaa     3720

gatgaattta aggagttgct agatgttgtg tcaaactttt ctaaaaaata tactttagca     3780

gaaggaaatt tagaaaaaat caaagaatta tatgcacaaa ataatggtga agatcttaaa     3840

gaattatcaa gttcatttat caacttatta acatttactg ctataggagc accagctgct     3900

tttaaattct ttgataaaaa tattgatcga aaacgatata cttcaactac tgaaattctc     3960

aacgctaccc tcatccacca atccatcacc ggtctttatg aaacgcggat tgatctcagt     4020

aagttaggag gagactaa                                                   4038


<210>  52
<211>  1345
<212>  PRT
<213>  Streptococcus mutans

<400>  52

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Leu Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210>  53
<211>  3366
<212>  DNA
<213>  Streptococcus thermophilus

<400>  53
atgagtgact tagttttagg acttgatatc ggtataggtt ctgttggtgt aggtatcctt       60

aacaaagtga caggagaaat tatccataaa aactcacgca tcttcccagc agctcaagcg      120

gaaaataacc tagtacgtag aacgaatcgt caaggaagac gcttgacacg acgtaaaaaa      180

catcgtagag ttcgtttaaa tcgtctattt gaggaaagtg gattaatcac cgattttacg      240

aagatttcaa ttaatcttaa cccatatcaa ttacgagtta agggcttgac cgatgaattg      300

tctaatgaag aactgtttat cgctcttaaa aatatggtga aacaccgtgg gattagttac      360

ctcgatgatg ctagtgatga cggaaattca tcaataggag actatgcaca aattgttaag      420

gaaaatagta aacaattaga aactaagaca ccgggacaga tacagttgga acgctaccaa      480

acatatggtc aattacgtgg tgattttact gttgagaaag atggcaaaaa acatcgcttg      540

attaatgtct ttccaacatc agcttatcgt tcagaagcct taaggatact gcaaactcaa      600

caagaattta atccacagat tacagatgaa tttattaatc gttatctcga aattttaact      660

ggaaaacgga aatattatca tggacccgga aatgaaaagt cacggactga ttatggtcgt      720

tacagaacga gtggagaaac tttagacaat atttttggaa ttctaattgg gaaatgtaca      780

ttttatccag acgagtttag agcagcaaaa gcttcctaca cggctcaaga attcaatttg      840

ctaaatgatt tgaacaatct aacagttcct actgaaacca aaaagttgag caaagaacag      900

aagaatcaaa tcattaatta tgtcaaaaat gaaaaggcaa tggggccagc gaaacttttt      960

aaatatatcg ctaagttact ttcttgtgat gttgcagata tcaagggata ccgtatcgac     1020

aaatcaggta aggctgagat tcatactttc gaagcctatc gaaaaatgaa aacgcttgaa     1080

accttagata ttgagcaaat ggatagagaa acgcttgata aattagccta tgtcttaaca     1140

ttaaacactg agagggaagg tattcaagaa gccttagaac atgaatttgc tgatggtagc     1200

tttagccaga agcaagttga cgaattggtt caattccgca aagcaaatag ttccattttt     1260

ggaaaaggat ggcataattt ttctgtcaaa ctgatgatgg agttaattcc agaattgtat     1320

gagacgtcag aagagcaaat gactatccta acacgacttg gaaaacaaaa aacgacttcg     1380

tcttcaaata aaacaaaata tatagatgaa aaactattaa ctgaagaaat ctataatcct     1440

gttgttgcta agtctgttcg ccaggctata aaaatcgtaa atgcggcgat taaagaatac     1500

ggagactttg acaatattgt catcgaaatg gctcgtgaaa caaatgaaga tgatgaaaag     1560

aaagctattc aaaagattca aaaagccaac aaagatgaaa aagatgcagc aatgcttaag     1620

gctgctaacc aatataatgg aaaggctgaa ttaccacata gtgttttcca cggtcataag     1680

caattagcga ctaaaatccg cctttggcat cagcaaggag aacgttgcct ttatactggt     1740

aagacaatct caatccatga tttgataaat aattctaatc agtttgaagt agatcatatt     1800

ttacctcttt ctatcacatt cgatgatagc cttgcaaata aggttttggt ttatgcaact     1860

gctaaccaag aaaaaggaca acgaacacct tatcaggctt tagatagtat ggatgatgcg     1920

tggtctttcc gtgaattaaa agcttttgta cgtgagtcaa aaacactttc gaacaagaaa     1980

aaagaatacc tccttacaga agaagatatt tcaaagtttg atgttcgaaa gaaatttatt     2040

gaacgaaatc ttgtagatac aagatacgct tcaagagttg tcctcaatgc ccttcaagaa     2100

cactttagag ctcacaagat tgatacaaaa gtttccgtgg ttcgtggcca atttacatct     2160

caattgagac gccattgggg aattgagaag actcgtgata cttatcatca ccatgctgtc     2220

gatgcattga ttattgccgc ctcaagtcag ttgaatttgt ggaaaaaaca aaagaatacc     2280

cttgtaagtt attcagaaga ccaactcctt gatattgaaa caggtgaact tattagtgat     2340

gatgagtaca aggaatctgt gttcaaagcc ccttatcaac attttgttga tacattgaag     2400

agtaaagaat ttgaagacag tatcttattc tcttatcaag tggattctaa gtttaatcgt     2460

aaaatatcag atgccactat ttatgcgaca agacaggcta aagtaggaaa agataaggcg     2520

gatgaaactt atgtcttagg gaaaatcaaa gatatttata ctcaggatgg ttatgatgcc     2580

tttatgaaga tttataagaa ggataagtca aaattcctca tgtatcgtca cgacccacaa     2640

acctttgaga aagttatcga gccaatttta gagaactatc ctaataagca aataaatgaa     2700

aaagggaaag aggtaccatg taatcctttc ctaaaatata aagaagaaca tggctatatt     2760

cgtaaatata gtaaaaaagg caatggtcct gaaatcaaga gtcttaaata ctatgatagt     2820

aagctaggca atcatattga tattactccg aaggatagta acaataaagt tgtcttacag     2880

tcagtttctc catggagagc ggatgtctat ttcaataaga ctactggaaa atacgaaatc     2940

ctcggattga aatatgctga tttacaattt gaaaaaggga caggaacata taagatttcc     3000

caggaaaaat acaatgacat taagaaaaaa gagggtgtag attctgattc agaattcaag     3060

tttacacttt ataaaaatga tttgttactc gttaaagata cagaaacaaa agaacaacag     3120

cttttccgtt ttctttctcg aactatgcct aaacaaaagc attatgttga attaaaacct     3180

tatgataaac agaaatttga aggaggtgag gcgttaatta aagtgttggg taacgttgct     3240

aatagtggtc aatgcaaaaa agggctagga aaatcaaata tttctattta taaggtaaga     3300

acagatgtcc taggaaatca gcatatcatc aaaaatgagg gtgataagcc taagctagat     3360

ttttaa                                                                3366


<210>  54
<211>  1122
<212>  PRT
<213>  Streptococcus thermophilus

<400>  54

Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Val Glu Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Arg Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Ser Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Glu Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Ser 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Pro 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Leu Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Lys Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Glu Met Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Leu Gly 
    930                 935                 940                 


Asn Pro Ile Asp Ile Thr Pro Glu Asn Ser Lys Asn Lys Val Val Leu 
945                 950                 955                 960 


Gln Ser Leu Lys Pro Trp Arg Ala Asp Val Tyr Phe Asn Lys Thr Thr 
                965                 970                 975     


Gly Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu 
            980                 985                 990         


Lys Lys Thr Gly Thr Tyr Lys Ile  Ser Gln Glu Lys Tyr  Asn Gly Ile 
        995                 1000                 1005             


Met Lys  Glu Glu Gly Val Asp  Ser Asp Ser Glu Phe  Lys Phe Thr 
    1010                 1015                 1020             


Leu Tyr  Lys Asn Asp Leu Leu  Leu Val Lys Asp Thr  Glu Thr Lys 
    1025                 1030                 1035             


Glu Gln  Gln Leu Phe Arg Phe  Leu Ser Arg Thr Met  Pro Asn Val 
    1040                 1045                 1050             


Lys Tyr  Tyr Val Glu Leu Lys  Pro Tyr Ser Lys Asp  Lys Phe Glu 
    1055                 1060                 1065             


Lys Asn  Glu Ser Leu Ile Glu  Ile Leu Gly Ser Ala  Asp Lys Ser 
    1070                 1075                 1080             


Gly Arg  Cys Ile Lys Gly Leu  Gly Lys Ser Asn Ile  Ser Ile Tyr 
    1085                 1090                 1095             


Lys Val  Arg Thr Asp Val Leu  Gly Asn Gln His Ile  Ile Lys Asn 
    1100                 1105                 1110             


Glu Gly  Asp Lys Pro Lys Leu  Asp Phe 
    1115                 1120         


<210>  55
<211>  2955
<212>  DNA
<213>  Campylobacter jejuni

<400>  55
gtggcaagaa ttttggcatt tgatatagga ataagctcta ttggctgggc atttagtgaa       60

aatgatgagt taaaagattg tggagttagg atttttacaa aggctgaaaa tcccaaaaca      120

ggagaatcct tagccttgcc aagacgcctt gcaagaagtg ctagaaaacg ccttgctaga      180

cgcaaagcaa ggctaaatca cttaaaacat ttaatcgcaa atgaatttaa gttaaattac      240

gaagattatc aaagctttga tgaaagttta gccaaggctt ataaaggatc tttaattagc      300

ccttatgagt taagatttag agctttaaac gagcttttaa gtaagcaaga ttttgcaaga      360

gtgattttac atattgcaaa aaggcgtggc tatgatgata ttaaaaatag tgatgataaa      420

gaaaaaggtg cgattttaaa agctatcaag caaaatgaag aaaaactagc aaattatcaa      480

agtgtgggcg agtatcttta taaagagtat tttcaaaaat tcaaagaaaa ttccaaagaa      540

tttacaaatg ttagaaataa aaaagaaagt tatgaacgct gcatagcgca aagtttttta      600

aaagatgaat taaagcttat ttttaaaaaa caaagagaat ttggcttttc tttttcaaaa      660

aaatttgaag aagaggtgct tagtgtagca ttttataaaa gggctttaaa agatttttct      720

catttggtgg gaaattgtag tttttttacc gatgaaaaaa gagcgccaaa aaattcgccc      780

ttagctttta tgtttgtagc acttacaaga attatcaatc ttttaaacaa tcttaaaaat      840

actgaaggaa ttttatatac aaaagatgat ttaaacgccc ttttgaatga agttttaaaa      900

aacggcactc taacttataa acaaacaaaa aagcttttgg gcttaagcga tgattatgaa      960

tttaaagggg aaaaaggaac ttattttatt gagtttaaaa aatataaaga atttataaaa     1020

gccttaggtg atcatagttt aagccaagat gatttaaatg aaatagcaaa agatattacc     1080

cttataaaag atgagattaa gcttaaaaag gctttagcaa aatatgattt aaatcaaaat     1140

caaattgata gtttaagcaa attggaattt aaagaccatt taaatataag ttttaaagcc     1200

ttaaaactta tcactccttt aatgcttgaa ggtaaaaaat acgatgaagc ttgtaatgag     1260

cttaatttaa aagtagcaat caatgaagat aaaaaagatt ttttacccgc atttaatgaa     1320

acttattata aagatgaggt aactaatcct gtggttttaa gagcgattaa agaatacaga     1380

aaggtcttaa atgctttact taaaaaatac ggcaaagtgc ataaaataaa cattgaatta     1440

gcaagagaag taggtaaaaa ttacagccaa agagctaaaa tagaaaaaga gcaaaatgaa     1500

aactacaagg ccaaaaaaga cgccgaactt gaatgtgaaa aactaggctt aaaaataaat     1560

agcaaaaata ttttaaaatt aagattattt aaagaacaaa aagaattttg tgcttatagt     1620

ggagaaaaga ttaaaattag tgatttgcaa gatgaaaaaa tgcttgaaat tgatcacatt     1680

tacccttatt ctagaagttt tgatgattct tatatgaata aagttttagt ttttaccaag     1740

caaaatcaag aaaaacttaa tcaaaccccc tttgaagcct ttggcaatga tagtgcaaaa     1800

tggcagaaaa ttgaagtttt agcaaaaaat ttacctacta aaaagcaaaa aagaatttta     1860

gataaaaatt acaaagacaa agagcaaaaa gactttaaag atagaaatct aaacgatact     1920

cgctacatcg caaggcttgt tttaaactac actaaagatt atttagattt tttaccttta     1980

agcgatgatg aaaatacaaa gttaaacgac acacaaaaag gctcaaaagt gcatgtagaa     2040

gcaaaaagcg gtatgcttac atcggcttta agacacactt ggggctttag cgctaaggat     2100

agaaataacc atcttcatca cgccatcgat gcagtaatta ttgcttatgc aaacaactct     2160

atcgtaaagg ctttttcaga ttttaaaaaa gagcaagaaa gcaacagtgc agaactttat     2220

gcaaaaaaaa ttagtgaatt agattataaa aacaaaagga agttttttga gccttttagt     2280

ggttttaggc aaaaggtttt agataaaatt gatgaaattt ttgtctcaaa acctgagaga     2340

aaaaagccaa gcggagcttt acatgaagaa acatttagaa aagaagaaga attctatcaa     2400

tcatacggcg gaaaagaagg agttttaaaa gccctagagc ttggtaaaat ccgcaaagta     2460

aatggtaaaa tagttaaaaa tggcgatatg tttagagtgg atatttttaa acacaaaaag     2520

acaaataaat tttatgctgt gccaatttat actatggatt ttgctttaaa agtattacca     2580

aataaagctg tagcacgaag taaaaaaggt gagataaaag actggatttt aatggatgaa     2640

aattatgagt tttgcttttc tttatacaaa gatagtttga ttttaattca aactaaagat     2700

atgcaagagc cagaatttgt ttattataat gcttttacaa gctctactgt tagtttgatt     2760

gtttcaaaac acgataataa atttgaaacg ctaagcaaaa atcaaaaaat attgtttaaa     2820

aatgcaaatg aaaaagaagt aatcgcaaaa agcataggaa ttcaaaatct aaaagtattt     2880

gaaaaataca tagtttcagc acttggggaa gttacaaagg ctgagtttag acaaagagaa     2940

gattttaaaa aatga                                                      2955


<210>  56
<211>  984
<212>  PRT
<213>  Campylobacter jejuni

<400>  56

Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210>  57
<211>  3249
<212>  DNA
<213>  Neisseria meningitides

<400>  57
atggctgcct tcaaacctaa tccaatcaac tacatcctcg gcctcgatat cggcatcgca       60

tccgtcggct gggcgatggt agaaattgac gaagatgaaa acccaatctg cctgattgat      120

ttgggcgtgc gcgtatttga gcgtgccgaa gtaccgaaaa caggcgactc ccttgccatg      180

gcaaggcgtt tggcgcgcag tgtccgccgc ctgacccgcc gtcgcgccca tcgcctgctt      240

cgggcccgcc gcctattgaa acgcgaaggc gtattacaag ccgctgattt tgacgaaaac      300

ggcttgatca aatccttacc gaatacacca tggcaacttc gcgcagccgc attagaccgc      360

aaactgacgc ctttagagtg gtcagcagtc ttgttgcatt taatcaaaca ccgcggttat      420

ttgtcgcaaa gaaaaaacga gggcgaaact gccgataaag agcttggcgc tttgctcaaa      480

ggcgtagccg acaatgccca tgccttacag acaggcgatt tccgcacacc ggccgaattg      540

gctttaaata aatttgagaa agaaagcggc catatccgca atcagcgcgg cgattattcg      600

catacgttca gccgcaaaga tttacaggcg gagctgattt tgctgtttga aaaacaaaaa      660

gaatttggca atccgcatgt ttcaggcggc cttaaagaag gtattgaaac cctactgatg      720

acgcaacgcc ctgccctgtc cggcgatgcc gttcaaaaaa tgttggggca ttgcaccttc      780

gaaccggcag agccgaaagc cgctaaaaac acctacacag ccgaacgttt catctggctg      840

accaagctga acaacctgcg tattttagag caaggcagcg agcggccatt gaccgatacc      900

gaacgcgcca cgcttatgga cgagccatac agaaaatcca aactgactta cgcacaagcc      960

cgtaagctgc tgggtttaga agataccgcc tttttcaaag gcttgcgcta tggtaaagac     1020

aatgccgaag cctcaacatt gatggaaatg aaggcctacc atgccatcag ccgtgcactg     1080

gaaaaagaag gattgaaaga caaaaaatcc ccattaaacc tttctcccga attacaagac     1140

gaaatcggca cggcattctc cctgttcaaa accgatgaag acattacagg ccgtctgaaa     1200

gaccgtatac agcccgaaat cttagaagcg ctgttgaaac acatcagctt cgataagttc     1260

gtccaaattt ccttgaaagc attgcgccga attgtgcctc taatggaaca aggcaaacgt     1320

tacgatgaag cctgcgccga aatctacgga gaccattacg gcaagaagaa tacggaagaa     1380

aagatttatc tgccgccgat tcccgccgac gaaatccgca accccgtcgt cttgcgcgcc     1440

ttatctcaag cacgtaaggt cattaacggc gtggtacgcc gttacggctc cccagctcgt     1500

atccatattg aaactgcaag ggaagtaggt aaatcgttta aagaccgcaa agaaattgag     1560

aaacgccaag aagaaaaccg caaagacagg gaaaaagccg ccgccaaatt ccgagagtat     1620

ttccccaatt ttgtcggaga acccaaatcc aaagatattc tgaaactgcg cctgtacgag     1680

caacaacacg gcaaatgcct gtattcgggc aaagaaatca acttaggccg tctgaacgaa     1740

aaaggctatg tcgaaatcga ccatgccctg ccgttctcgc gcacatggga cgacagtttc     1800

aacaataaag tactggtatt gggcagcgaa aaccaaaaca aaggcaatca aaccccttac     1860

gaatacttca acggcaaaga caacagccgc gaatggcagg aatttaaagc gcgtgtcgaa     1920

accagccgtt tcccgcgcag taaaaaacaa cggattctgc tgcaaaaatt cgatgaagac     1980

ggctttaaag aacgcaatct gaacgacacg cgctacgtca accgtttcct gtgtcaattt     2040

gttgccgacc gtatgcggct gacaggtaaa ggcaagaaac gtgtctttgc atccaacgga     2100

caaattacca atctgttgcg cggcttttgg ggattgcgca aagtgcgtgc ggaaaacgac     2160

cgccatcacg ccttggacgc cgtcgtcgtt gcctgctcga ccgttgccat gcagcagaaa     2220

attacccgtt ttgtacgcta taaagagatg aacgcgtttg acggtaaaac catagacaaa     2280

gaaacaggag aagtgctgca tcaaaaaaca cacttcccac aaccttggga atttttcgca     2340

caagaagtca tgattcgcgt cttcggcaaa ccggacggca aacccgaatt cgaagaagcc     2400

gataccccag aaaaactgcg cacgttgctt gccgaaaaat tatcatctcg ccccgaagcc     2460

gtacacgaat acgttacgcc actgtttgtt tcacgcgcgc ccaatcggaa gatgagcggg     2520

caagggcata tggagaccgt caaatccgcc aaacgactgg acgaaggcgt cagcgtgttg     2580

cgcgtaccgt taacacagtt aaaactgaaa gacttggaaa aaatggtcaa tcgggagcgc     2640

gaacctaagc tatacgaagc actgaaagca cggctggaag cacataaaga cgatcctgcc     2700

aaagcctttg ccgagccgtt ttacaaatac gataaagcag gcaaccgcac ccaacaggta     2760

aaagccgtac gcgtagagca agtacagaaa accggcgtat gggtgcgcaa ccataacggt     2820

attgccgaca acgcaaccat ggtgcgcgta gatgtgtttg agaaaggcga caagtattat     2880

ctggtaccga tttacagttg gcaggtagcg aaagggattt tgccggatag ggctgttgta     2940

caaggaaaag atgaagaaga ttggcaactt attgatgata gtttcaactt taaattctca     3000

ttacacccta atgatttagt cgaggttata acaaaaaaag ctagaatgtt tggttacttt     3060

gccagctgcc atcgaggcac cggtaatatc aatatacgca ttcatgatct tgatcataaa     3120

attggcaaaa atggaatact ggaaggtatc ggcgtcaaaa ccgccctttc attccaaaaa     3180

taccaaattg acgaactggg cgaagaaatc agaccatgcc gtctgaaaaa acgcccgcct     3240

gtccgttaa                                                             3249


<210>  58
<211>  1082
<212>  PRT
<213>  Neisseria meningitides

<400>  58

Met Ala Ala Phe Lys Pro Asn Ser Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Lys Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Ala Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Thr Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asn 
                85                  90                  95      


Phe Asp Lys Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Leu Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Gly Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Asn Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Ile Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Thr Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Thr Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Ser Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Thr Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Val 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Ile Leu Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Leu Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210>  59
<211>  4890
<212>  DNA
<213>  Francisella novicida

<400>  59
atgaatttca aaatattgcc aatagcaata gatttaggtg ttaaaaatac tggtgtcttt       60

agcgcatttt atcaaaaagg aacttctctt gagagattgg ataataaaaa tggcaaagta      120

tatgaactat caaaagattc ttatacttta ttgatgaata atagaacagc aagaagacat      180

caaagaagag ggatagatag aaagcagcta gtcaaaaggc tctttaagct tatttggaca      240

gagcagctaa atttagagtg ggataaagac actcaacaag caattagctt tttatttaat      300

cgtagaggtt ttagttttat tactgatggt tattcgcctg aatatttaaa tattgttcca      360

gagcaagtaa aagcgatact tatggatata tttgatgatt acaacggtga agatgattta      420

gacagttatt taaaattagc tactgagcaa gaaagcaaaa tttctgaaat ttataacaag      480

ctaatgcaaa aaatattaga gtttaaatta atgaaattat gtactgatat taaggatgat      540

aaagtaagta ctaaaacgct taaagaaatc acaagctatg aatttgagtt attagctgat      600

tatttagcaa actatagcga gagtttaaaa acacaaaaat ttagttatac agataaacaa      660

ggtaatttaa aagagctaag ctactatcat catgataaat ataatattca agaatttcta      720

aagcgacatg ctactataaa tgatcgaatt ttagatactc ttttaactga tgatttagat      780

atttggaatt ttaattttga gaaatttgat tttgataaga atgaagaaaa gcttcagaat      840

caggaagata aagatcatat acaagcgcat ttacatcatt ttgtttttgc agtaaataaa      900

ataaaaagtg aaatggcaag tggtggtcgt catcgtagcc aatattttca agagataaca      960

aatgtgctag atgaaaataa tcatcaagag ggatatctca agaatttctg tgaaaatttg     1020

cataataaaa aatattcaaa tttaagtgtt aaaaatttag ttaatctaat tggtaaccta     1080

agtaatttag agctaaaacc gctaagaaaa tattttaatg acaaaattca cgcaaaagct     1140

gatcattggg atgagcaaaa gtttacagaa acttattgcc actggatatt aggagagtgg     1200

cgagtaggtg tcaaagatca agataagaaa gatggcgcta aatatagtta taaagatctg     1260

tgtaatgaat taaaacaaaa agttactaag gctggtttgg tagatttttt attagagtta     1320

gatccatgta gaactatacc accatatctg gataacaata accgtaaacc accaaaatgt     1380

caaagtttga ttttaaatcc gaagttttta gataatcaat atccaaactg gcaacaatat     1440

ttacaagaat taaagaaact acaaagtatt caaaattatt tagacagttt tgaaactgat     1500

ttaaaagtct taaagtcaag taaagatcaa ccatattttg ttgaatacaa gagttcaaat     1560

cagcaaatag caagtggtca aagagattat aaagatttag atgctcgaat attacagttt     1620

atatttgata gggtaaaagc tagtgatgag ttgcttttga atgagattta ttttcaggct     1680

aaaaaactta aacaaaaagc tagctctgag ttagaaaaac tcgagtcgag caaaaagcta     1740

gatgaagtta tagcaaatag tcaactatca cagatactaa agtctcaaca tacaaatggt     1800

atttttgaac agggtacttt tttgcatttg gtttgtaaat attataaaca aagacaaaga     1860

gcgagagact ctaggctata tattatgcct gaatatcgtt atgataaaaa actacataaa     1920

tataacaata caggcaggtt tgatgatgat aatcagctgc taacatattg taatcataag     1980

ccaagacaaa aaagatacca attgttaaat gatttagctg gggtgttgca ggtatcacct     2040

aattttttga aagataaaat tggttctgat gatgatctat ttattagcaa atggttggta     2100

gagcatatta gaggatttaa aaaagcttgt gaagatagtt taaaaataca aaaagacaat     2160

agaggattat taaatcataa aataaatata gctaggaata caaaaggcaa atgtgaaaaa     2220

gaaatattta atttaatatg taaaatagaa ggttcagaag ataaaaaagg taattacaag     2280

catggtttag cttacgaatt aggagtactt ttatttggtg aacctaatga agctagtaaa     2340

cctgagttcg atagaaaaat taaaaaattt aactcaatat acagttttgc acagattcaa     2400

caaattgctt ttgcagagcg taaaggcaat gctaacactt gtgcagtttg tagtgctgat     2460

aatgctcata gaatgcaaca aattaagatc actgagcctg tagaggacaa taaagataag     2520

ataatcttaa gtgccaaagc tcagagacta ccagcgattc caactagaat agttgacggt     2580

gcggttaaga aaatggcaac tatattagct aaaaatatag ttgatgataa ttggcagaat     2640

atcaaacaag ttttatcagc aaaacatcag ttacatatac ctattatcac agaatcaaat     2700

gcttttgagt ttgaaccagc attagctgat gtaaaaggta agagcctaaa agataggaga     2760

aaaaaagcat tagagagaat aagtcctgaa aatatattca aggataaaaa caatagaata     2820

aaagaatttg ctaaaggtat atcagcatat agtggtgcta atttaactga tggcgatttt     2880

gatggtgcaa aagaagaatt agatcatata atacctcgtt cacataaaaa atacggtact     2940

ctaaatgatg aagcaaatct aatttgtgta actcgtggtg ataataaaaa taaaggtaat     3000

agaattttct gcctacgtga tcttgcagat aactataaac taaaacagtt tgagacaact     3060

gatgatttag aaattgaaaa gaagatagct gatacaatct gggatgctaa caagaaagat     3120

tttaaatttg gtaattatcg tagttttatt aacctaacac cacaagagca gaaagcattt     3180

cgtcacgcgc tatttctggc tgatgaaaat cctatcaaac aagcagtcat aagagcgata     3240

aataatcgta atcgtacatt tgtaaatggc actcaacgct attttgcaga agtactggca     3300

aacaatatct atctaagggc taaaaaagaa aatctaaata cagataaaat ttcatttgat     3360

tattttggta ttccaactat aggtaatggt agaggtattg ctgaaatccg tcaactttat     3420

gaaaaagttg atagtgatat acaagcttat gcaaaaggtg ataaacctca agctagctac     3480

tctcacctaa tagatgcgat gctggctttt tgtattgctg ctgatgaaca cagaaatgat     3540

ggaagtatag gtctagaaat cgataaaaat tatagtttat atccattaga taaaaataca     3600

ggagaagtct ttaccaaaga tatttttagt caaattaaaa ttactgataa tgagtttagc     3660

gataaaaaat tagtaagaaa aaaagctata gagggcttta acacgcatag acaaatgact     3720

agagatggca tttatgcaga aaattaccta ccaatactaa tccataaaga actaaatgaa     3780

gttagaaaag gctatacttg gaaaaatagt gaagaaataa aaatattcaa aggtaaaaag     3840

tacgatatac aacaattgaa taaccttgtg tattgtctaa aatttgtaga taaacctata     3900

tctatagata tacaaattag taccttagaa gagttaagaa atatattaac aacaaataat     3960

atagctgcta cagcagaata ctattatata aatctaaaaa cccaaaaatt acatgagtat     4020

tatatcgaaa actataatac tgccttaggt tataaaaaat acagtaaaga aatggagttt     4080

ttgagaagct tagcttatcg tagcgaaagg gtaaaaatta aatcaataga tgatgtaaag     4140

caggttttgg ataaggatag taactttatc atcggtaaga ttactttacc atttaaaaaa     4200

gagtggcaaa gactatatcg tgagtggcaa aatacaacta tcaaagatga ttatgagttt     4260

ttaaaatcat tctttaatgt taaaagtatt actaagttgc ataaaaaagt tagaaaagat     4320

ttctctttac ctatttctac aaatgaaggt aaattcctgg tcaaaagaaa aacatgggat     4380

aacaatttta tctatcagat attaaatgat tctgattcta gagcagacgg aacaaagcca     4440

tttattccag cttttgacat ttctaaaaat gaaatagtcg aagccataat tgattcattt     4500

acatcaaaaa atattttttg gctgcctaaa aatatagaat tacaaaaggt ggataataaa     4560

aacatttttg ctatagatac tagtaaatgg ttcgaagtag aaacacctag tgatcttaga     4620

gacattggaa tagcaacaat tcaatacaag atagataata attctcgccc taaagtcaga     4680

gttaaacttg attatgttat cgatgatgat agtaagataa attattttat gaatcattct     4740

ttattaaaat caagatatcc tgacaaagtt ttagaaattt taaaacaatc aactattata     4800

gaatttgaaa gttcaggttt taataaaact atcaaagaaa tgcttggtat gaaattagca     4860

ggtatttata atgaaacatc taataattag                                      4890


<210>  60
<211>  1629
<212>  PRT
<213>  Francisella novicida

<400>  60

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  61
<211>  3171
<212>  DNA
<213>  Pasteurella multocida

<400>  61
atgcaaacaa caaatttaag ttatatttta ggtttagatt tggggatcgc ttctgtaggt       60

tgggctgtcg ttgaaatcaa tgaaaatgaa gaccctatcg gcttgattga tgtaggagta      120

aggatatttg agcgtgctga ggtacccaaa actggagaat ctttagcact ctctcgccgt      180

cttgcaagaa gtactcgccg tttgatacgc cgtcgtgcac gccgtttact cctcgcaaaa      240

cgcttcttaa aacgtgaagg tatactttcc acaaccgact tagaaaaagg attacctaac      300

caagcttggg aattacgtgt cgccggtctt gaacgtcggt tatccgccat agaatggggt      360

gcggttctgc tacatttaat caagcatcga ggttatcttt ctaaacgtaa aaatgaatcc      420

caaacaaata acaaagaatt aggagcctta ctctctggag tggcacaaaa ccatcaatta      480

ttacaatcag atgactaccg aacaccagca gagctcgcac tgaaaaaatt tgctaaagaa      540

gaagggcata tccgtaatca acgaggtgcc tatacacata catttaatcg attagattta      600

ttagccgaac ttaacttgct ttttgctcaa caacatcagt ttggtaatcc acattgtaaa      660

gagcatattc agcaatatat gacagaattg cttatgtggc aaaagcctgc cttatctggt      720

gaggcaattt taaaaatgtt gggtaaatgt acgcatgaaa aaaatgagtt taaagcagca      780

aaacatactt acagtgcgga acgctttgtt tggctaacca aactcaataa cttgcgcatt      840

ttagaagatg gggcagaacg agctcttaat gaagaagaac gtcaactatt gataaatcat      900

ccgtatgaga aatcaaaatt aacctatgcc caagtcagaa aattgttagg gctttccgaa      960

caagcgattt ttaagcatct acgttatagt aaagaaaacg cagaatcagc tacttttatg     1020

gagcttaaag cttggcatgc aattcgtaaa gcgttagaaa atcaaggatt gaaggatact     1080

tggcaggatc tcgctaagaa acctgactta ctagatgaaa ttggtaccgc attttctctt     1140

tataaaactg atgaagatat tcagcaatat ttgacaaata aggtacctaa ttcagtcatc     1200

aatgcattat tagtttttct gaatttcgat aaattcattg agttagcttt gaaaagttta     1260

cgtaaaatct tgcccctaat ggagcaaggt aagcgttatg atcaagcttg tcgtgaaatt     1320

tatgggcatc attatggcga ggcaaatcaa aaaacttctc agctactacc agctattcca     1380

gcccaagaaa ttcgtaatcc tgttgtttta cgtacacttt cacaagcacg taaagtgatc     1440

aatgccatta ttcgtcaata tggttcccct gctcgagtcc atattgaaac aggaagagaa     1500

cttgggaaat cttttaaaga acgtcgtgaa attcaaaaac aacaggaaga taatcgaact     1560

aagcgagaaa gtgcggtaca aaaattcaaa gaattatttt ctgacttttc aagtgaaccc     1620

aaaagtaaag atattttaaa attccgctta tacgaacaac agcatggtaa atgcttatac     1680

tctggaaaag agatcaatat tcatcgctta aatgaaaagg gttatgtgga aattgatcat     1740

gctttacctt tctcacggac ttgggatgac agttttaata ataaagtatt agttcttgcc     1800

agcgaaaacc aaaacaaagg gaatcaaaca ccgtatgaat ggctacaagg taaaataaat     1860

tcggaacgtt ggaaaaactt tgttgcttta gtactgggta gccagtgcag tgcagccaag     1920

aaacaacgat tactcactca agttattgat gataataaat ttattgatag aaacttaaat     1980

gatactcgct atattgcccg attcctatcc aactatattc aagaaaattt gcttttggtg     2040

ggtaaaaata agaaaaatgt ctttacacca aacggtcaaa ttactgcatt attaagaagt     2100

cgctggggat taattaagat tcgtgagaat aatgaccgtc atcatgcttt agatgcgata     2160

gttgtggctt gtgcaacacc ttctatgcaa caaaaaatta ctcgatttat tcgatttaaa     2220

gaagtgcatc catacaaaat agaaaatagg tatgaaatgg tggatcaaga aagcggagaa     2280

attatttcac ctcattttcc tgaaccttgg gcttatttta gacaagaggt taatattcgt     2340

gtttttgata atcatccaga tactgtctta aaagagatgc tacctgatcg cccacaagca     2400

aatcaccagt ttgtacagcc cctttttgtt tctcgtgctc caactcgtaa aatgagtggt     2460

caagggcata tggaaacaat taaatcagct aaacgcttag cagaaggcat tagcgtttta     2520

agaattcctc tcacgcaatt aaaacctaat ttattggaaa atatggtgaa taaagaacgt     2580

gagccagcac tttatgcagg actaaaagca cgcttggctg aatttaatca agatccagca     2640

aaagcgttta ctacgccttt ttataaacaa ggagggcagc aggtcaaagc tattcgtgtt     2700

gaacaggtac aaaaatcagg ggtattagtc agagaaaaca atggggtagc agataatgcc     2760

tctatcgttc gaacagacgt atttatcaaa aataataaat ttttccttgt tcctatctat     2820

acttggcaag ttgcgaaagg catcttgcca aataaagcta ttgttgctca taaaaatgaa     2880

gatgaatggg aagaaatgga tgaaggtgct aagtttaaat tcagcctttt cccgaatgat     2940

cttgtcgagc taaaaaccaa aaaagaatac tttttcggct attacatcgg actagatcgt     3000

gcaactggaa acattagcct aaaagaacat gatggtgaga tatcaaaagg taaagacggt     3060

gtttaccgtg ttggtgtcaa gttagctctt tcttttgaaa aatatcaagt tgatgagctc     3120

ggtaaaaata gacaaatttg ccgacctcag caaagacaac ctgtgcgtta a              3171


<210>  62
<211>  1056
<212>  PRT
<213>  Pasteurella multocida

<400>  62

Met Gln Thr Thr Asn Leu Ser Tyr Ile Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Val Gly Trp Ala Val Val Glu Ile Asn Glu Asn Glu Asp Pro 
            20                  25                  30          


Ile Gly Leu Ile Asp Val Gly Val Arg Ile Phe Glu Arg Ala Glu Val 
        35                  40                  45              


Pro Lys Thr Gly Glu Ser Leu Ala Leu Ser Arg Arg Leu Ala Arg Ser 
    50                  55                  60                  


Thr Arg Arg Leu Ile Arg Arg Arg Ala Arg Arg Leu Leu Leu Ala Lys 
65                  70                  75                  80  


Arg Phe Leu Lys Arg Glu Gly Ile Leu Ser Thr Thr Asp Leu Glu Lys 
                85                  90                  95      


Gly Leu Pro Asn Gln Ala Trp Glu Leu Arg Val Ala Gly Leu Glu Arg 
            100                 105                 110         


Arg Leu Ser Ala Ile Glu Trp Gly Ala Val Leu Leu His Leu Ile Lys 
        115                 120                 125             


His Arg Gly Tyr Leu Ser Lys Arg Lys Asn Glu Ser Gln Thr Asn Asn 
    130                 135                 140                 


Lys Glu Leu Gly Ala Leu Leu Ser Gly Val Ala Gln Asn His Gln Leu 
145                 150                 155                 160 


Leu Gln Ser Asp Asp Tyr Arg Thr Pro Ala Glu Leu Ala Leu Lys Lys 
                165                 170                 175     


Phe Ala Lys Glu Glu Gly His Ile Arg Asn Gln Arg Gly Ala Tyr Thr 
            180                 185                 190         


His Thr Phe Asn Arg Leu Asp Leu Leu Ala Glu Leu Asn Leu Leu Phe 
        195                 200                 205             


Ala Gln Gln His Gln Phe Gly Asn Pro His Cys Lys Glu His Ile Gln 
    210                 215                 220                 


Gln Tyr Met Thr Glu Leu Leu Met Trp Gln Lys Pro Ala Leu Ser Gly 
225                 230                 235                 240 


Glu Ala Ile Leu Lys Met Leu Gly Lys Cys Thr His Glu Lys Asn Glu 
                245                 250                 255     


Phe Lys Ala Ala Lys His Thr Tyr Ser Ala Glu Arg Phe Val Trp Leu 
            260                 265                 270         


Thr Lys Leu Asn Asn Leu Arg Ile Leu Glu Asp Gly Ala Glu Arg Ala 
        275                 280                 285             


Leu Asn Glu Glu Glu Arg Gln Leu Leu Ile Asn His Pro Tyr Glu Lys 
    290                 295                 300                 


Ser Lys Leu Thr Tyr Ala Gln Val Arg Lys Leu Leu Gly Leu Ser Glu 
305                 310                 315                 320 


Gln Ala Ile Phe Lys His Leu Arg Tyr Ser Lys Glu Asn Ala Glu Ser 
                325                 330                 335     


Ala Thr Phe Met Glu Leu Lys Ala Trp His Ala Ile Arg Lys Ala Leu 
            340                 345                 350         


Glu Asn Gln Gly Leu Lys Asp Thr Trp Gln Asp Leu Ala Lys Lys Pro 
        355                 360                 365             


Asp Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp 
    370                 375                 380                 


Glu Asp Ile Gln Gln Tyr Leu Thr Asn Lys Val Pro Asn Ser Val Ile 
385                 390                 395                 400 


Asn Ala Leu Leu Val Phe Leu Asn Phe Asp Lys Phe Ile Glu Leu Ala 
                405                 410                 415     


Leu Lys Ser Leu Arg Lys Ile Leu Pro Leu Met Glu Gln Gly Lys Arg 
            420                 425                 430         


Tyr Asp Gln Ala Cys Arg Glu Ile Tyr Gly His His Tyr Gly Glu Ala 
        435                 440                 445             


Asn Gln Lys Thr Ser Gln Leu Leu Pro Ala Ile Pro Ala Gln Glu Ile 
    450                 455                 460                 


Arg Asn Pro Val Val Leu Arg Thr Leu Ser Gln Ala Arg Lys Val Ile 
465                 470                 475                 480 


Asn Ala Ile Ile Arg Gln Tyr Gly Ser Pro Ala Arg Val His Ile Glu 
                485                 490                 495     


Thr Gly Arg Glu Leu Gly Lys Ser Phe Lys Glu Arg Arg Glu Ile Gln 
            500                 505                 510         


Lys Gln Gln Glu Asp Asn Arg Thr Lys Arg Glu Ser Ala Val Gln Lys 
        515                 520                 525             


Phe Lys Glu Leu Phe Ser Asp Phe Ser Ser Glu Pro Lys Ser Lys Asp 
    530                 535                 540                 


Ile Leu Lys Phe Arg Leu Tyr Glu Gln Gln His Gly Lys Cys Leu Tyr 
545                 550                 555                 560 


Ser Gly Lys Glu Ile Asn Ile His Arg Leu Asn Glu Lys Gly Tyr Val 
                565                 570                 575     


Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe 
            580                 585                 590         


Asn Asn Lys Val Leu Val Leu Ala Ser Glu Asn Gln Asn Lys Gly Asn 
        595                 600                 605             


Gln Thr Pro Tyr Glu Trp Leu Gln Gly Lys Ile Asn Ser Glu Arg Trp 
    610                 615                 620                 


Lys Asn Phe Val Ala Leu Val Leu Gly Ser Gln Cys Ser Ala Ala Lys 
625                 630                 635                 640 


Lys Gln Arg Leu Leu Thr Gln Val Ile Asp Asp Asn Lys Phe Ile Asp 
                645                 650                 655     


Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ala Arg Phe Leu Ser Asn Tyr 
            660                 665                 670         


Ile Gln Glu Asn Leu Leu Leu Val Gly Lys Asn Lys Lys Asn Val Phe 
        675                 680                 685             


Thr Pro Asn Gly Gln Ile Thr Ala Leu Leu Arg Ser Arg Trp Gly Leu 
    690                 695                 700                 


Ile Lys Ile Arg Glu Asn Asn Asp Arg His His Ala Leu Asp Ala Ile 
705                 710                 715                 720 


Val Val Ala Cys Ala Thr Pro Ser Met Gln Gln Lys Ile Thr Arg Phe 
                725                 730                 735     


Ile Arg Phe Lys Glu Val His Pro Tyr Lys Ile Glu Asn Arg Tyr Glu 
            740                 745                 750         


Met Val Asp Gln Glu Ser Gly Glu Ile Ile Ser Pro His Phe Pro Glu 
        755                 760                 765             


Pro Trp Ala Tyr Phe Arg Gln Glu Val Asn Ile Arg Val Phe Asp Asn 
    770                 775                 780                 


His Pro Asp Thr Val Leu Lys Glu Met Leu Pro Asp Arg Pro Gln Ala 
785                 790                 795                 800 


Asn His Gln Phe Val Gln Pro Leu Phe Val Ser Arg Ala Pro Thr Arg 
                805                 810                 815     


Lys Met Ser Gly Gln Gly His Met Glu Thr Ile Lys Ser Ala Lys Arg 
            820                 825                 830         


Leu Ala Glu Gly Ile Ser Val Leu Arg Ile Pro Leu Thr Gln Leu Lys 
        835                 840                 845             


Pro Asn Leu Leu Glu Asn Met Val Asn Lys Glu Arg Glu Pro Ala Leu 
    850                 855                 860                 


Tyr Ala Gly Leu Lys Ala Arg Leu Ala Glu Phe Asn Gln Asp Pro Ala 
865                 870                 875                 880 


Lys Ala Phe Thr Thr Pro Phe Tyr Lys Gln Gly Gly Gln Gln Val Lys 
                885                 890                 895     


Ala Ile Arg Val Glu Gln Val Gln Lys Ser Gly Val Leu Val Arg Glu 
            900                 905                 910         


Asn Asn Gly Val Ala Asp Asn Ala Ser Ile Val Arg Thr Asp Val Phe 
        915                 920                 925             


Ile Lys Asn Asn Lys Phe Phe Leu Val Pro Ile Tyr Thr Trp Gln Val 
    930                 935                 940                 


Ala Lys Gly Ile Leu Pro Asn Lys Ala Ile Val Ala His Lys Asn Glu 
945                 950                 955                 960 


Asp Glu Trp Glu Glu Met Asp Glu Gly Ala Lys Phe Lys Phe Ser Leu 
                965                 970                 975     


Phe Pro Asn Asp Leu Val Glu Leu Lys Thr Lys Lys Glu Tyr Phe Phe 
            980                 985                 990         


Gly Tyr Tyr Ile Gly Leu Asp Arg  Ala Thr Gly Asn Ile  Ser Leu Lys 
        995                 1000                 1005             


Glu His  Asp Gly Glu Ile Ser  Lys Gly Lys Asp Gly  Val Tyr Arg 
    1010                 1015                 1020             


Val Gly  Val Lys Leu Ala Leu  Ser Phe Glu Lys Tyr  Gln Val Asp 
    1025                 1030                 1035             


Glu Leu  Gly Lys Asn Arg Gln  Ile Cys Arg Pro Gln  Gln Arg Gln 
    1040                 1045                 1050             


Pro Val  Arg 
    1055     


<210>  63
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  63
agtgggatct caagaactac                                                   20


<210>  64
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  64
tccgctgagg gtttaattaa tggttcactt ctctttag                               38


<210>  65
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  65
gtagttcttg agatcccact tgcatcatcc gtgaatc                                37


<210>  66
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  66
tcggctgagg tcttaattaa agcagctcta tatcacg                                37


<210>  67
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  67
agtgggatct caagaactac gttttagagc tagaaatagc                             40


<210>  68
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  68
tccgctgagg gtttaattaa aaccggagag tactatcaac                             40


<210>  69
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  69
gtagttcttg agatcccact tgcatcatcc gtgaatcg                               38


<210>  70
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  70
agtgggatct caagaactac gttttagagc tagaaatagc                             40


<210>  71
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  71
tcggctgagg tcttaattaa tttttttctg gatcctacag                             40


<210>  72
<211>  6651
<212>  DNA
<213>  Aspergillus oryzae

<400>  72
atggaggggc cacgcggcgt ctatctcttc ggagaccaga caagtgattt cgacgccggc       60

ttacgtcgcc tcctacaagt aaagaataac acaattgttg catcgttctt ccagagatgc      120

tttcacgctt tgcgccaaga gatcgcgagg ctttcaccat ctgaacggaa gatcttcccc      180

cggtttacga gcatagtgga tctactggcg cgtcaccggg agtcagaccc taatccggct      240

ctggagagtg cgttgacctg tatctatcaa ttgggatgct ttataaagta cgtgtaactg      300

cagatcctga cccgtttgaa cgagcctaac ctgagatagc tactacggag accttggaaa      360

cgtgtaccca tctgcttcag actgccatat agttggcctg tgcgcgggtc ttcttagttc      420

tgcagctgta agctgttcga acaatgttgg agaattgctc cccgctgcgg ttgaagcggt      480

ggtggtagct ctccgacttg gtctatgcgt ccttaaagtt cgagagctgg tgagctctga      540

ccaagcgtcg tcaacaagct ggtcagtctt gatttcaggg attagcgaga aagatgcctc      600

gcagcttata ggagaattca ctgctgaacg ggtaagtcaa ttgatctgaa atagtttgca      660

ggacagaatg ttctaaccac tggataaagg caattcctcc ttcatccaaa ccgtatatca      720

gtgcggtggg atataacagt ataaccatca gcgcaccgcc taaggtcctt gatgatttaa      780

ttgattctag gctgtctaag agccataagc cggtgagggc gcaaatccat ggtccttacc      840

atgcagcaca tctgtactat ggccgagatg tcgacaggat catcgaaagc tgccataatg      900

aggtcgtttc aaactacaca ccccgtatcc ccgtactatc aagtactacg ggacagccga      960

tagaggccaa acacatgaaa gatctactta aggccgccct tgaagagatt ctactacgtc     1020

aactatgctg ggagaaagtg accgatgcct gctattccat attaaaaact gctcgtcatc     1080

aaccatgcaa gttgttccca atttcaagca ctgcgacaca aagcttgttt acagctctta     1140

cgaaagccgg gataaccgac atcgaagtgg aaaatgggct cggagatgtt cccacgaacc     1200

cgaaggacaa ccttaacatc agcggcaggg cggactgctc caagatagct atcattggca     1260

tgtctggacg attcccagaa gctgatggca cagagagttt ctgggacctt ctgtataatg     1320

gcctcgatgt acaccggaag gtgcctgcag agcgttggga tgttgatgcc cacgttgatc     1380

ctaccggaac aaaacggaac accagcaagg ttccatacgg atgctggata aacgaaccgg     1440

ggttatttga cccccgcttc ttcaatatgt cgccacgcga agccctccag gcagatcccg     1500

ctcaaagact tgcattgctc acggcctatg aagctcttga aatggccggc tttatccccg     1560

acagcacccc ttctacacag agggatcgag tcggcctctt ctatggaatg actagcgatg     1620

actatcggga gataaatagt ggtcaagata ttgatactta ctttatccct ggtgggaatc     1680

gtgctttcac acctggccgg ataaactact atttcaagtt cagtgggccc agcgtcagcg     1740

ttgatacagc ttgttcttca agtcttgcgg ctattcatat ggcttgcaat tcgatctgga     1800

gaaatgattg cgatgctgct attgctggag gtgtcaatat attgacaaac cctgataacc     1860

atgccggtct tgaccgtggc catttcctgt ccagaaccgg gaattgcaac acatttgacg     1920

atggtgctga tggctactgt agagcagatg gagtgggtac aatcattctc aagcggctgg     1980

aagacgctca ggcggacaac gatccaatcc tcggtgtgat caatggagcc tataccaatc     2040

attcggcaga agcagtctcg attacccgcc ctcatgttgg cgcacaagcg tttatcttta     2100

ataagctatt gaacgatgcc aatatcgacc ctaaggacgt cagctacgtt gaaatgcatg     2160

gaactggtac tcaagctggg gatgcggtgg aaatgcaatc ggtcttggat acgtttgctc     2220

ccgactaccg ccgtggacca ggacagtctc tccatcttgg ttccgccaaa gcaaatgttg     2280

ggcatggaga gtcagcatct ggtgtaactg cacttgtgaa agtgctgcta atgatgaaga     2340

agaataccat accccctcat tgtggtataa agactaagat caaccacaac ttccccacgg     2400

atctcgcgca acgaaatgtc cacattgcct ttcaacctac cccttggaac agaccggctt     2460

ccggaaagcg gcagtgcttc attaacaact tttcggcggc tggtggaaat accgctcttt     2520

tgatggaaga cgctccaatc gctgaggtta aggggcagga cactcgacct gttcacgttg     2580

tgtctgtatc ggcacgatcc cagagtgcgc tcaaaaacaa catcaactct ctcgtaaaat     2640

acatcgacga acaaggaagg tcattcaatg tgaacgaggc agactttatc ccaagcttgg     2700

catacaccac cacagcacgg cgtatccatc acccattccg tgtcacagct atcgggtcta     2760

gtttgcagga gctgcgtgac tcacttaaca acagctctcg tctggaaagc tttacccctg     2820

tccctgcgac ggcccctggc gtagggttcg tgttcgctgg ccaaggagct cagcacaccg     2880

gaatgggaag gcaactatac gaaaaatgct ctcaattccg ggcaacaatg cagcacttcg     2940

attgcattag tcaaaaccaa gggtttcctt cgatccttcc cttggttgac ggaagcgtgc     3000

ccgtggagga gctgggccct atcgtgacac agctcggcac cacatgtctt cagatggctt     3060

tggtcaacta ttggggttca ctaggtataa aacctgcgtt cgttcttggg catagtctcg     3120

gggagtttgc tgctttgaat accgcaggag tattatcgac ttccgatacc atctaccttt     3180

gtggccgtcg ggctaccctc cttacagaat actgccaggt tgggacacac gccatgctgg     3240

ctgtcaaggc ttcctacccc caggtcaagc agttactgaa agaaggtgtg gatgaagttg     3300

cctgtgtcaa ctcacccagt gagacagtcg tcagtggcct caccgctgat attgatgact     3360

tggctcaaag gtgttccact gaaggttgga agtccactaa actaagggta ccgttcgctt     3420

tccattctgc ccaagttact ccaattcttg aacggtttca agaagaggcc cagggtgtca     3480

cgttccgtaa gccgtcgtta ccgtttgttt cctcactcct tggggaagtc atcaccgaat     3540

ctaattacga tgtcctggga gctcaatata tggtgaagca gtgccggaag tcggtgaact     3600

tccttggtgc tcttgaggcc accagatatg cgaaattgat gactgataag actgtctggc     3660

tggaagttgg tgcccatacc atttgctctg gtatgatcaa agcaacattc ggtccccagg     3720

ttaccactgt ggcatctctt cgccgagagg agaatgcatg gaaggtcctc tccaatagtc     3780

tatcggccct tcatttggct ggcattgata ttaattggaa agaatatcat caagacttca     3840

gctccagcca ccaggtgctc ccacttcctt cttacaagtg ggatctcaag aactactgga     3900

taccctacac taacaatttc tgccttacga agggtgctcc ccaaactgca attcaagctg     3960

caccacaaac tacattcctg accactgctg cgcaaaaggt tgttgagagt cgcgacgacg     4020

gtacaacagc gactgtcgtg gtgcaaaatg acatcgctga tcctgagttg aaccgtgtta     4080

tccaaggtca caaggtcaat ggagccgcac tttgcccatc ggtaagtatt gcatgcattg     4140

ccagactatc ttgtgttata attcggctac ttacgtattg cctagtcact ctacgcagat     4200

attgcccaga cacttggaga gtatcttatt gagaaataca aacccgagtt caaagatctt     4260

ggtctcgatg tgtgtgacat ggtcgtaccg aagccactca tcgcgaaggg aggagagcag     4320

ctctttagag tctctgctat tgctaattgg gctgagaaga aggcttcagt tcaagtatac     4380

gccgttaatg ctgacggcaa aaagaccgtg gatcatgcgt attgtacggt gaagttcttt     4440

gataccaatg cctccgagct cgagtggaag agaatctcgt acctggtcaa gagaagcatc     4500

gacagtcttc accagaatgc ggagacaggg gaggctcacc gtatccagcg aggaatggtc     4560

tataaacttt tcagcgcgtt ggtcgattat gatgaaaatt tcaagtcgat tcgcgaggtt     4620

atcctggaca gcgacaataa tgaggccacc gctcgtgtca aattccaagc accgccagga     4680

aatttccacc gaaacccatt ctggattgac agtttcggtc acttgtccgg attcattatg     4740

aatgcgagcg acgcgaccga ctctaagaac caagtatttg ttaaccatgg atgggattcg     4800

atgcgttgcc tgaagaagtt ctcgcctgat gtcacttatc gcacttatgt gaggatgcag     4860

ccatggcaaa acaacatttg ggctggagat gtttatatct ttgagggcga cgatattatt     4920

gctgtcttcg gaggtgtgaa ggtgggtacc tcactactga ttttggttcc tgcttactga     4980

catgataatt agttccaagc actggcacgc aagatacttg acactgttct tccccctgtt     5040

ggcggttcaa aggcaccaat tacagcgaaa tcaccacctc cagctcgcac tcagaaggcc     5100

aacaccggcg ccaagacccg tcctaaagca cctgttcctt ccaagtcgtt caccaaatct     5160

tctgggccga gtgttgtcgt acgcgcactc agcattctgg cctcagaagt tggcctggca     5220

gagtctgaaa tctcagacga catggtgttt gcggactacg gtgtagactc actcctctcc     5280

cttacagtta ctggcaggta tcgtgaagag ttgaacctcg atttggactc ctctgtgttt     5340

accgatcatc caactgtcaa cgacttcaag cggctcatcg cccaagtgag tccttcagag     5400

agccatgatg gttcctccag tgaacaagag tcgaatttct ctttcaacgg tggcgagtcc     5460

tcaagcgcaa gcacacctga cataacgtca ccgccgaatg agaaggtagc tcaagtcgag     5520

caaaacggca ccatgaagga aatccgtaac atcatggcgg aggagatcgg tgtacccgca     5580

gaagagatcg accctgacga gaacttggga gagatgggta tggactcgct tctctccctt     5640

actgttcttg gaagaatacg ggagactttg gacatggacc tgccaggaga gttcttcatc     5700

gaaaaccaga ccctcaatga tatagaggtg gctttggacc taaaacccaa gactacctct     5760

gctccaattc ctatgccaga gccagtgaaa ttccctgaag ctatccacga cctccagcca     5820

aagcttgctc aacatcccaa ggccacatcc atcctgttac aaggaaaccc caggacagca     5880

acaaagacgt tattcttgtt tcctgacggc tctggctcag ctacatctta cgctaccatc     5940

cccggactct ctcctgacgt ctgcgtttac gggttgaatt gcccatatat gaagacacct     6000

gagaagctca aatgcagcct agatgaactc actgcgccct atgtagcaga gattcgtcgt     6060

cggcaaccca agggtcctta cagcttcggt ggctggtcag caggagggat ctgtgcatat     6120

gatgcggcac gccatctaat gtttgaggaa ggtgaacaag tcgaccgctt gcttctcctt     6180

gataccccct tccccatcgg cctcgagaag ctgccgcaga gattgtacgg cttcttcaac     6240

tctatcggtc tcttcggtga aggtaaaacg gcaccaccct cctggctcct accccacttc     6300

ctagccttta tcgacgctct cgacgcatac aaggccgcgc cccttccatt caaagacgag     6360

aaatgggcca agaaactgcc caagacttat atcatctggg ccaaggacgg tgtttgcggt     6420

aagccgggag atccccggcc tgatcccccg acagacggtt ccaaggatcc caaggagatg     6480

gtctggcttc ttaatgaccg gaccgatctg ggacctaaca agtgggatac attggttgga     6540

cctgagaata ttggtggaat cacagtaatg gaagatgcta atcattttac gatgacgaag     6600

ggcgaaaaag cgaaagagtt gtctacattt atggctaacg ccatggctta a              6651


<210>  73
<211>  2141
<212>  PRT
<213>  Aspergillus oryzae

<400>  73

Met Glu Gly Pro Arg Gly Val Tyr Leu Phe Gly Asp Gln Thr Ser Asp 
1               5                   10                  15      


Phe Asp Ala Gly Leu Arg Arg Leu Leu Gln Val Lys Asn Asn Thr Ile 
            20                  25                  30          


Val Ala Ser Phe Phe Gln Arg Cys Phe His Ala Leu Arg Gln Glu Ile 
        35                  40                  45              


Ala Arg Leu Ser Pro Ser Glu Arg Lys Ile Phe Pro Arg Phe Thr Ser 
    50                  55                  60                  


Ile Val Asp Leu Leu Ala Arg His Arg Glu Ser Asp Pro Asn Pro Ala 
65                  70                  75                  80  


Leu Glu Ser Ala Leu Thr Cys Ile Tyr Gln Leu Gly Cys Phe Ile Asn 
                85                  90                  95      


Tyr Tyr Gly Asp Leu Gly Asn Val Tyr Pro Ser Ala Ser Asp Cys His 
            100                 105                 110         


Ile Val Gly Leu Cys Ala Gly Leu Leu Ser Ser Ala Ala Val Ser Cys 
        115                 120                 125             


Ser Asn Asn Val Gly Glu Leu Leu Pro Ala Ala Val Glu Ala Val Val 
    130                 135                 140                 


Val Ala Leu Arg Leu Gly Leu Cys Val Leu Lys Val Arg Glu Leu Val 
145                 150                 155                 160 


Ser Ser Asp Gln Ala Ser Ser Thr Ser Trp Ser Val Leu Ile Ser Gly 
                165                 170                 175     


Ile Ser Glu Lys Asp Ala Ser Gln Leu Ile Gly Glu Phe Thr Ala Glu 
            180                 185                 190         


Arg Ala Ile Pro Pro Ser Ser Lys Pro Tyr Ile Ser Ala Val Gly Tyr 
        195                 200                 205             


Asn Ser Ile Thr Ile Ser Ala Pro Pro Lys Val Leu Asp Asp Leu Ile 
    210                 215                 220                 


Asp Ser Arg Leu Ser Lys Ser His Lys Pro Val Arg Ala Gln Ile His 
225                 230                 235                 240 


Gly Pro Tyr His Ala Ala His Leu Tyr Tyr Gly Arg Asp Val Asp Arg 
                245                 250                 255     


Ile Ile Glu Ser Cys His Asn Glu Val Val Ser Asn Tyr Thr Pro Arg 
            260                 265                 270         


Ile Pro Val Leu Ser Ser Thr Thr Gly Gln Pro Ile Glu Ala Lys His 
        275                 280                 285             


Met Lys Asp Leu Leu Lys Ala Ala Leu Glu Glu Ile Leu Leu Arg Gln 
    290                 295                 300                 


Leu Cys Trp Glu Lys Val Thr Asp Ala Cys Tyr Ser Ile Leu Lys Thr 
305                 310                 315                 320 


Ala Arg His Gln Pro Cys Lys Leu Phe Pro Ile Ser Ser Thr Ala Thr 
                325                 330                 335     


Gln Ser Leu Phe Thr Ala Leu Thr Lys Ala Gly Ile Thr Asp Ile Glu 
            340                 345                 350         


Val Glu Asn Gly Leu Gly Asp Val Pro Thr Asn Pro Lys Asp Asn Leu 
        355                 360                 365             


Asn Ile Ser Gly Arg Ala Asp Cys Ser Lys Ile Ala Ile Ile Gly Met 
    370                 375                 380                 


Ser Gly Arg Phe Pro Glu Ala Asp Gly Thr Glu Ser Phe Trp Asp Leu 
385                 390                 395                 400 


Leu Tyr Asn Gly Leu Asp Val His Arg Lys Val Pro Ala Glu Arg Trp 
                405                 410                 415     


Asp Val Asp Ala His Val Asp Pro Thr Gly Thr Lys Arg Asn Thr Ser 
            420                 425                 430         


Lys Val Pro Tyr Gly Cys Trp Ile Asn Glu Pro Gly Leu Phe Asp Pro 
        435                 440                 445             


Arg Phe Phe Asn Met Ser Pro Arg Glu Ala Leu Gln Ala Asp Pro Ala 
    450                 455                 460                 


Gln Arg Leu Ala Leu Leu Thr Ala Tyr Glu Ala Leu Glu Met Ala Gly 
465                 470                 475                 480 


Phe Ile Pro Asp Ser Thr Pro Ser Thr Gln Arg Asp Arg Val Gly Leu 
                485                 490                 495     


Phe Tyr Gly Met Thr Ser Asp Asp Tyr Arg Glu Ile Asn Ser Gly Gln 
            500                 505                 510         


Asp Ile Asp Thr Tyr Phe Ile Pro Gly Gly Asn Arg Ala Phe Thr Pro 
        515                 520                 525             


Gly Arg Ile Asn Tyr Tyr Phe Lys Phe Ser Gly Pro Ser Val Ser Val 
    530                 535                 540                 


Asp Thr Ala Cys Ser Ser Ser Leu Ala Ala Ile His Met Ala Cys Asn 
545                 550                 555                 560 


Ser Ile Trp Arg Asn Asp Cys Asp Ala Ala Ile Ala Gly Gly Val Asn 
                565                 570                 575     


Ile Leu Thr Asn Pro Asp Asn His Ala Gly Leu Asp Arg Gly His Phe 
            580                 585                 590         


Leu Ser Arg Thr Gly Asn Cys Asn Thr Phe Asp Asp Gly Ala Asp Gly 
        595                 600                 605             


Tyr Cys Arg Ala Asp Gly Val Gly Thr Ile Ile Leu Lys Arg Leu Glu 
    610                 615                 620                 


Asp Ala Gln Ala Asp Asn Asp Pro Ile Leu Gly Val Ile Asn Gly Ala 
625                 630                 635                 640 


Tyr Thr Asn His Ser Ala Glu Ala Val Ser Ile Thr Arg Pro His Val 
                645                 650                 655     


Gly Ala Gln Ala Phe Ile Phe Asn Lys Leu Leu Asn Asp Ala Asn Ile 
            660                 665                 670         


Asp Pro Lys Asp Val Ser Tyr Val Glu Met His Gly Thr Gly Thr Gln 
        675                 680                 685             


Ala Gly Asp Ala Val Glu Met Gln Ser Val Leu Asp Thr Phe Ala Pro 
    690                 695                 700                 


Asp Tyr Arg Arg Gly Pro Gly Gln Ser Leu His Leu Gly Ser Ala Lys 
705                 710                 715                 720 


Ala Asn Val Gly His Gly Glu Ser Ala Ser Gly Val Thr Ala Leu Val 
                725                 730                 735     


Lys Val Leu Leu Met Met Lys Lys Asn Thr Ile Pro Pro His Cys Gly 
            740                 745                 750         


Ile Lys Thr Lys Ile Asn His Asn Phe Pro Thr Asp Leu Ala Gln Arg 
        755                 760                 765             


Asn Val His Ile Ala Phe Gln Pro Thr Pro Trp Asn Arg Pro Ala Ser 
    770                 775                 780                 


Gly Lys Arg Gln Cys Phe Ile Asn Asn Phe Ser Ala Ala Gly Gly Asn 
785                 790                 795                 800 


Thr Ala Leu Leu Met Glu Asp Ala Pro Ile Ala Glu Val Lys Gly Gln 
                805                 810                 815     


Asp Thr Arg Pro Val His Val Val Ser Val Ser Ala Arg Ser Gln Ser 
            820                 825                 830         


Ala Leu Lys Asn Asn Ile Asn Ser Leu Val Lys Tyr Ile Asp Glu Gln 
        835                 840                 845             


Gly Arg Ser Phe Asn Val Asn Glu Ala Asp Phe Ile Pro Ser Leu Ala 
    850                 855                 860                 


Tyr Thr Thr Thr Ala Arg Arg Ile His His Pro Phe Arg Val Thr Ala 
865                 870                 875                 880 


Ile Gly Ser Ser Leu Gln Glu Leu Arg Asp Ser Leu Asn Asn Ser Ser 
                885                 890                 895     


Arg Leu Glu Ser Phe Thr Pro Val Pro Ala Thr Ala Pro Gly Val Gly 
            900                 905                 910         


Phe Val Phe Ala Gly Gln Gly Ala Gln His Thr Gly Met Gly Arg Gln 
        915                 920                 925             


Leu Tyr Glu Lys Cys Ser Gln Phe Arg Ala Thr Met Gln His Phe Asp 
    930                 935                 940                 


Cys Ile Ser Gln Asn Gln Gly Phe Pro Ser Ile Leu Pro Leu Val Asp 
945                 950                 955                 960 


Gly Ser Val Pro Val Glu Glu Leu Gly Pro Ile Val Thr Gln Leu Gly 
                965                 970                 975     


Thr Thr Cys Leu Gln Met Ala Leu Val Asn Tyr Trp Gly Ser Leu Gly 
            980                 985                 990         


Ile Lys Pro Ala Phe Val Leu Gly  His Ser Leu Gly Glu  Phe Ala Ala 
        995                 1000                 1005             


Leu Asn  Thr Ala Gly Val Leu  Ser Thr Ser Asp Thr  Ile Tyr Leu 
    1010                 1015                 1020             


Cys Gly  Arg Arg Ala Thr Leu  Leu Thr Glu Tyr Cys  Gln Val Gly 
    1025                 1030                 1035             


Thr His  Ala Met Leu Ala Val  Lys Ala Ser Tyr Pro  Gln Val Lys 
    1040                 1045                 1050             


Gln Leu  Leu Lys Glu Gly Val  Asp Glu Val Ala Cys  Val Asn Ser 
    1055                 1060                 1065             


Pro Ser  Glu Thr Val Val Ser  Gly Leu Thr Ala Asp  Ile Asp Asp 
    1070                 1075                 1080             


Leu Ala  Gln Arg Cys Ser Thr  Glu Gly Trp Lys Ser  Thr Lys Leu 
    1085                 1090                 1095             


Arg Val  Pro Phe Ala Phe His  Ser Ala Gln Val Thr  Pro Ile Leu 
    1100                 1105                 1110             


Glu Arg  Phe Gln Glu Glu Ala  Gln Gly Val Thr Phe  Arg Lys Pro 
    1115                 1120                 1125             


Ser Leu  Pro Phe Val Ser Ser  Leu Leu Gly Glu Val  Ile Thr Glu 
    1130                 1135                 1140             


Ser Asn  Tyr Asp Val Leu Gly  Ala Gln Tyr Met Val  Lys Gln Cys 
    1145                 1150                 1155             


Arg Lys  Ser Val Asn Phe Leu  Gly Ala Leu Glu Ala  Thr Arg Tyr 
    1160                 1165                 1170             


Ala Lys  Leu Met Thr Asp Lys  Thr Val Trp Leu Glu  Val Gly Ala 
    1175                 1180                 1185             


His Thr  Ile Cys Ser Gly Met  Ile Lys Ala Thr Phe  Gly Pro Gln 
    1190                 1195                 1200             


Val Thr  Thr Val Ala Ser Leu  Arg Arg Glu Glu Asn  Ala Trp Lys 
    1205                 1210                 1215             


Val Leu  Ser Asn Ser Leu Ser  Ala Leu His Leu Ala  Gly Ile Asp 
    1220                 1225                 1230             


Ile Asn  Trp Lys Glu Tyr His  Gln Asp Phe Ser Ser  Ser His Gln 
    1235                 1240                 1245             


Val Leu  Pro Leu Pro Ser Tyr  Lys Trp Asp Leu Lys  Asn Tyr Trp 
    1250                 1255                 1260             


Ile Pro  Tyr Thr Asn Asn Phe  Cys Leu Thr Lys Gly  Ala Pro Gln 
    1265                 1270                 1275             


Thr Ala  Ile Gln Ala Ala Pro  Gln Thr Thr Phe Leu  Thr Thr Ala 
    1280                 1285                 1290             


Ala Gln  Lys Val Val Glu Ser  Arg Asp Asp Gly Thr  Thr Ala Thr 
    1295                 1300                 1305             


Val Val  Val Gln Asn Asp Ile  Ala Asp Pro Glu Leu  Asn Arg Val 
    1310                 1315                 1320             


Ile Gln  Gly His Lys Val Asn  Gly Ala Ala Leu Cys  Pro Ser Ser 
    1325                 1330                 1335             


Leu Tyr  Ala Asp Ile Ala Gln  Thr Leu Gly Glu Tyr  Leu Ile Glu 
    1340                 1345                 1350             


Lys Tyr  Lys Pro Glu Phe Lys  Asp Leu Gly Leu Asp  Val Cys Asp 
    1355                 1360                 1365             


Met Val  Val Pro Lys Pro Leu  Ile Ala Lys Gly Gly  Glu Gln Leu 
    1370                 1375                 1380             


Phe Arg  Val Ser Ala Ile Ala  Asn Trp Ala Glu Lys  Lys Ala Ser 
    1385                 1390                 1395             


Val Gln  Val Tyr Ala Val Asn  Ala Asp Gly Lys Lys  Thr Val Asp 
    1400                 1405                 1410             


His Ala  Tyr Cys Thr Val Lys  Phe Phe Asp Thr Asn  Ala Ser Glu 
    1415                 1420                 1425             


Leu Glu  Trp Lys Arg Ile Ser  Tyr Leu Val Lys Arg  Ser Ile Asp 
    1430                 1435                 1440             


Ser Leu  His Gln Asn Ala Glu  Thr Gly Glu Ala His  Arg Ile Gln 
    1445                 1450                 1455             


Arg Gly  Met Val Tyr Lys Leu  Phe Ser Ala Leu Val  Asp Tyr Asp 
    1460                 1465                 1470             


Glu Asn  Phe Lys Ser Ile Arg  Glu Val Ile Leu Asp  Ser Asp Asn 
    1475                 1480                 1485             


Asn Glu  Ala Thr Ala Arg Val  Lys Phe Gln Ala Pro  Pro Gly Asn 
    1490                 1495                 1500             


Phe His  Arg Asn Pro Phe Trp  Ile Asp Ser Phe Gly  His Leu Ser 
    1505                 1510                 1515             


Gly Phe  Ile Met Asn Ala Ser  Asp Ala Thr Asp Ser  Lys Asn Gln 
    1520                 1525                 1530             


Val Phe  Val Asn His Gly Trp  Asp Ser Met Arg Cys  Leu Lys Lys 
    1535                 1540                 1545             


Phe Ser  Pro Asp Val Thr Tyr  Arg Thr Tyr Val Arg  Met Gln Pro 
    1550                 1555                 1560             


Trp Gln  Asn Asn Ile Trp Ala  Gly Asp Val Tyr Ile  Phe Glu Gly 
    1565                 1570                 1575             


Asp Asp  Ile Ile Ala Val Phe  Gly Gly Val Lys Phe  Gln Ala Leu 
    1580                 1585                 1590             


Ala Arg  Lys Ile Leu Asp Thr  Val Leu Pro Pro Val  Gly Gly Ser 
    1595                 1600                 1605             


Lys Ala  Pro Ile Thr Ala Lys  Ser Pro Pro Pro Ala  Arg Thr Gln 
    1610                 1615                 1620             


Lys Ala  Asn Thr Gly Ala Lys  Thr Arg Pro Lys Ala  Pro Val Pro 
    1625                 1630                 1635             


Ser Lys  Ser Phe Thr Lys Ser  Ser Gly Pro Ser Val  Val Val Arg 
    1640                 1645                 1650             


Ala Leu  Ser Ile Leu Ala Ser  Glu Val Gly Leu Ala  Glu Ser Glu 
    1655                 1660                 1665             


Ile Ser  Asp Asp Met Val Phe  Ala Asp Tyr Gly Val  Asp Ser Leu 
    1670                 1675                 1680             


Leu Ser  Leu Thr Val Thr Gly  Arg Tyr Arg Glu Glu  Leu Asn Leu 
    1685                 1690                 1695             


Asp Leu  Asp Ser Ser Val Phe  Thr Asp His Pro Thr  Val Asn Asp 
    1700                 1705                 1710             


Phe Lys  Arg Leu Ile Ala Gln  Val Ser Pro Ser Glu  Ser His Asp 
    1715                 1720                 1725             


Gly Ser  Ser Ser Glu Gln Glu  Ser Asn Phe Ser Phe  Asn Gly Gly 
    1730                 1735                 1740             


Glu Ser  Ser Ser Ala Ser Thr  Pro Asp Ile Thr Ser  Pro Pro Asn 
    1745                 1750                 1755             


Glu Lys  Val Ala Gln Val Glu  Gln Asn Gly Thr Met  Lys Glu Ile 
    1760                 1765                 1770             


Arg Asn  Ile Met Ala Glu Glu  Ile Gly Val Pro Ala  Glu Glu Ile 
    1775                 1780                 1785             


Asp Pro  Asp Glu Asn Leu Gly  Glu Met Gly Met Asp  Ser Leu Leu 
    1790                 1795                 1800             


Ser Leu  Thr Val Leu Gly Arg  Ile Arg Glu Thr Leu  Asp Met Asp 
    1805                 1810                 1815             


Leu Pro  Gly Glu Phe Phe Ile  Glu Asn Gln Thr Leu  Asn Asp Ile 
    1820                 1825                 1830             


Glu Val  Ala Leu Asp Leu Lys  Pro Lys Thr Thr Ser  Ala Pro Ile 
    1835                 1840                 1845             


Pro Met  Pro Glu Pro Val Lys  Phe Pro Glu Ala Ile  His Asp Leu 
    1850                 1855                 1860             


Gln Pro  Lys Leu Ala Gln His  Pro Lys Ala Thr Ser  Ile Leu Leu 
    1865                 1870                 1875             


Gln Gly  Asn Pro Arg Thr Ala  Thr Lys Thr Leu Phe  Leu Phe Pro 
    1880                 1885                 1890             


Asp Gly  Ser Gly Ser Ala Thr  Ser Tyr Ala Thr Ile  Pro Gly Leu 
    1895                 1900                 1905             


Ser Pro  Asp Val Cys Val Tyr  Gly Leu Asn Cys Pro  Tyr Met Lys 
    1910                 1915                 1920             


Thr Pro  Glu Lys Leu Lys Cys  Ser Leu Asp Glu Leu  Thr Ala Pro 
    1925                 1930                 1935             


Tyr Val  Ala Glu Ile Arg Arg  Arg Gln Pro Lys Gly  Pro Tyr Ser 
    1940                 1945                 1950             


Phe Gly  Gly Trp Ser Ala Gly  Gly Ile Cys Ala Tyr  Asp Ala Ala 
    1955                 1960                 1965             


Arg His  Leu Met Phe Glu Glu  Gly Glu Gln Val Asp  Arg Leu Leu 
    1970                 1975                 1980             


Leu Leu  Asp Thr Pro Phe Pro  Ile Gly Leu Glu Lys  Leu Pro Gln 
    1985                 1990                 1995             


Arg Leu  Tyr Gly Phe Phe Asn  Ser Ile Gly Leu Phe  Gly Glu Gly 
    2000                 2005                 2010             


Lys Thr  Ala Pro Pro Ser Trp  Leu Leu Pro His Phe  Leu Ala Phe 
    2015                 2020                 2025             


Ile Asp  Ala Leu Asp Ala Tyr  Lys Ala Ala Pro Leu  Pro Phe Lys 
    2030                 2035                 2040             


Asp Glu  Lys Trp Ala Lys Lys  Leu Pro Lys Thr Tyr  Ile Ile Trp 
    2045                 2050                 2055             


Ala Lys  Asp Gly Val Cys Gly  Lys Pro Gly Asp Pro  Arg Pro Asp 
    2060                 2065                 2070             


Pro Pro  Thr Asp Gly Ser Lys  Asp Pro Lys Glu Met  Val Trp Leu 
    2075                 2080                 2085             


Leu Asn  Asp Arg Thr Asp Leu  Gly Pro Asn Lys Trp  Asp Thr Leu 
    2090                 2095                 2100             


Val Gly  Pro Glu Asn Ile Gly  Gly Ile Thr Val Met  Glu Asp Ala 
    2105                 2110                 2115             


Asn His  Phe Thr Met Thr Lys  Gly Glu Lys Ala Lys  Glu Leu Ser 
    2120                 2125                 2130             


Thr Phe  Met Ala Asn Ala Met  Ala 
    2135                 2140     


<210>  74
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  74
cattctggtg aagactgtcg                                                   20


<210>  75
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  75
cttcagctcc agccaccagc tgccttacga agggtgc                                37


<210>  76
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  76
gcacccttcg taaggcagct ggtggctgga gctgaag                                37


<210>  77
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  77
ctggctgtca aggcttcc                                                     18


<210>  78
<211>  949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Sequence

<400>  78
ttgcctgcag gcatgcaagc tttctgctcg aggccatctg gcttttctct gctgtctgcc       60

tcgggaatgg gatggaatac cacgtacggt atttggcctc cggtgccatc cgaagcgaga      120

tgctttgagc ttgaaacccc ctcggcctgc acaggtgtct catcgtgcat ttaatccaac      180

ggcggcgagt caaaacatca gctaattgac caggtttctg gattgtgaat gccaactttt      240

tgggtcttga ggagttgcgg ggtgggaaaa aagtaaagaa atttactgag gattttatca      300

ttgcgactat aaaataaagc ggcattgcaa atccttgcgt tgctactatg taaaatggac      360

tgtagttgtg ctgctgaaaa tagtttggcg attgtggatt gtggattgtg gattgtggat      420

tatggcaagt tgtcaagggg caagttgacg aaaatgattg tgtggtgtct gccagcaaat      480

tgagaacgtg ggtatatatt tcatcttttc atgattccct tcggcttgct tgtcaagcaa      540

tggcatcatt ggtctagtgg tagaattcgt cgttgccatc gacgaggccc gtgttcgatt      600

cacggatgat gcagctggat gagaataccc tcggttttag agctagaaat agcaagttaa      660

aataaggcta gtccgttatc aacttgaaaa agtggcaccg agtcggtgct ttttttttgg      720

ctcttgggtt cgaactgccc aaggcccatg ttttggtcat cttttttttt atgccccacc      780

atttgggtca cccctgccaa tcattccatc tttgttccta cccttcacgt gtgctttccg      840

aagccaaagt tcccattcaa caactctcct tgcgtttttt ttttcttgaa gcttgtcacc      900

cgtcgatagt ttctgccatt tgcaataagc ttcgagacag cagaatcac                  949


<210>  79
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  79
ctctctcaca ctttggataa catcaagcat a                                      31


<210>  80
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  80
tatgcttgat gttatccaaa gtgtgagaga g                                      31


<210>  81
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  81
ccacaaaaca taacacaacc ttcaccatga acaacggcac aaacaacttc c                51


<210>  82
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  82
gatatcttcg tatgtcgaag tatccgag                                          28


<210>  83
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  83
ctcggatact tcgacatacg aagatatc                                          28


<210>  84
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  84
cggcataaat cgaatgtccg ctcacacctt tcgcttcttc ttcgg                       45


<210>  85
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  85
atcatgtaac tcgccttgat cgttg                                             25


<210>  86
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  86
caacgatcaa ggcgagttac atgat                                             25


<210>  87
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  87
cggaaacagc tatgaccatg agatc                                             25


<210>  88
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  88
gatctcatgg tcatagctgt ttccgttaat taatcctcgt gtactgtgta agcgccc          57


<210>  89
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  89
gcggacattc gatttatgcc g                                                 21


<210>  90
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  90
ggtgaaggtt gtgttatgtt ttgtgg                                            26


<210>  91
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  91
gatctcatgg tcatagctgt ttccgttaat taacgagaca gcagaatcac cgc              53


<210>  92
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  92
gggcgcttac acagtacacg aggagtattg ggatgaattt tgtatgcacg                  50


<210>  93
<211>  3792
<212>  DNA
<213>  Eubacterium rectale

<400>  93
atgaacaacg gcacaaataa ttttcagaac ttcatcggga tctcaagttt gcagaaaacg       60

ctgcgcaatg ctctgatccc cacggaaacc acgcaacagt tcatcgtcaa gaacggaata      120

attaaagaag atgagttacg tggcgagaac cgccagattc tgaaagatat catggatgac      180

tactaccgcg gattcatctc tgagactctg agttctattg atgacataga ttggactagc      240

ctgttcgaaa aaatggaaat tcagctgaaa aatggtgata ataaagatac cttaattaag      300

gaacagacag agtatcggaa agcaatccat aaaaaatttg cgaacgacga tcggtttaag      360

aacatgttta gcgccaaact gattagtgac atattacctg aatttgtcat ccacaacaat      420

aattattcgg catcagagaa agaggaaaaa acccaggtga taaaattgtt ttcgcgcttt      480

gcgactagct ttaaagatta cttcaagaac cgtgcaaatt gcttttcagc ggacgatatt      540

tcatcaagca gctgccatcg catcgtcaac gacaatgcag agatattctt ttcaaatgcg      600

ctggtctacc gccggatcgt aaaatcgctg agcaatgacg atatcaacaa aatttcgggc      660

gatatgaaag attcattaaa agaaatgagt ctggaagaaa tatattctta cgagaagtat      720

ggggaattta ttacccagga aggcattagc ttctataatg atatctgtgg gaaagtgaat      780

tcttttatga acctgtattg tcagaaaaat aaagaaaaca aaaatttata caaacttcag      840

aaacttcaca aacagattct atgcattgcg gacactagct atgaggtccc gtataaattt      900

gaaagtgacg aggaagtgta ccaatcagtt aacggcttcc ttgataacat tagcagcaaa      960

catatagtcg aaagattacg caaaatcggc gataactata acggctacaa cctggataaa     1020

atttatatcg tgtccaaatt ttacgagagc gttagccaaa aaacctaccg cgactgggaa     1080

acaattaata ccgccctcga aattcattac aataatatct tgccgggtaa cggtaaaagt     1140

aaagccgaca aagtaaaaaa agcggttaag aatgatttac agaaatccat caccgaaata     1200

aatgaactag tgtcaaacta taagctgtgc agtgacgaca acatcaaagc ggagacttat     1260

atacatgaga ttagccatat cttgaataac tttgaagcac aggaattgaa atacaatccg     1320

gaaattcacc tagttgaatc cgagctcaaa gcgagtgagc ttaaaaacgt gctggacgtg     1380

atcatgaatg cgtttcattg gtgttcggtt tttatgactg aggaacttgt tgataaagac     1440

aacaattttt atgcggaact ggaggagatt tacgatgaaa tttatccagt aattagtctg     1500

tacaacctgg ttcgtaacta cgttacccag aaaccgtaca gcacgaaaaa gattaaattg     1560

aactttggaa taccgacgtt agcagacggt tggtcaaagt ccaaagagta ttctaataac     1620

gctatcatac tgatgcgcga caatctgtat tatctgggca tctttaatgc gaagaataaa     1680

ccggacaaga agattatcga gggtaatacg tcagaaaata agggtgacta caaaaagatg     1740

atttataatt tgctcccggg tcccaacaaa atgatcccga aagttttctt gagcagcaag     1800

acgggggtgg aaacgtataa accgagcgcc tatatcctag aggggtataa acagaataaa     1860

catatcaagt cttcaaaaga ctttgatatc actttctgtc atgatctgat cgactacttc     1920

aaaaactgta ttgcaattca tcccgagtgg aaaaacttcg gttttgattt tagcgacacc     1980

agtacttatg aagacatttc cgggttttat cgtgaggtag agttacaagg ttacaagatt     2040

gattggacat acattagcga aaaagacatt gatctgctgc aggaaaaagg tcaactgtat     2100

ctgttccaga tatataacaa agatttttcg aaaaaatcaa ccgggaatga caaccttcac     2160

accatgtacc tgaaaaatct tttctcagaa gaaaatctta aggatatcgt cctgaaactt     2220

aacggcgaag cggaaatctt cttcaggaag agcagcataa agaacccaat cattcataaa     2280

aaaggctcga ttttagtcaa ccgtacctac gaagcagaag aaaaagacca gtttggcaac     2340

attcaaattg tgcgtaaaaa tattccggaa aacatttatc aggagctgta caaatacttc     2400

aacgataaaa gcgacaaaga gctgtctgat gaagcagcca aactgaagaa tgtagtggga     2460

caccacgagg cagcgacgaa tatagtcaag gactatcgct acacgtatga taaatacttc     2520

cttcatatgc ctattacgat caatttcaaa gccaataaaa cgggttttat taatgatagg     2580

atcttacagt atatcgctaa agaaaaagac ttacatgtga tcggcattga tcggggcgag     2640

cgtaacctga tctacgtgtc cgtgattgat acttgtggta atatagttga acagaaaagc     2700

tttaacattg taaacggcta cgactatcag ataaaactga aacaacagga gggcgctaga     2760

cagattgcgc ggaaagaatg gaaagaaatt ggtaaaatta aagagatcaa agagggctac     2820

ctgagcttag taatccacga gatctctaaa atggtaatca aatacaatgc aattatagcg     2880

atggaggatt tgtcttatgg ttttaaaaaa gggcgcttta aggtcgaacg gcaagtttac     2940

cagaaatttg aaaccatgct catcaataaa ctcaactatc tggtatttaa agatatttcg     3000

attaccgaga atggcggtct cctgaaaggt tatcagctga catacattcc tgataaactt     3060

aaaaacgtgg gtcatcagtg cggctgcatt ttttatgtgc ctgctgcata cacgagcaaa     3120

attgatccga ccaccggctt tgtgaatatc tttaaattta aagacctgac agtggacgca     3180

aaacgtgaat tcattaaaaa atttgactca attcgttatg acagtgaaaa aaatctgttc     3240

tgctttacat ttgactacaa taactttatt acgcaaaaca cggtcatgag caaatcatcg     3300

tggagtgtgt atacatacgg cgtgcgcatc aaacgtcgct ttgtgaacgg ccgcttctca     3360

aacgaaagtg ataccattga cataaccaaa gatatggaga aaacgttgga aatgacggac     3420

attaactggc gcgatggcca cgatcttcgt caagacatta tagattatga aattgttcag     3480

cacatattcg aaattttccg tttaacagtg caaatgcgta actccttgtc tgaactggag     3540

gaccgtgatt acgatcgtct catttcacct gtactgaacg aaaataacat tttttatgac     3600

agcgcgaaag cgggggatgc acttcctaag gatgccgatg caaatggtgc gtattgtatt     3660

gcattaaaag ggttatatga aattaaacaa attaccgaaa attggaaaga agatggtaaa     3720

ttttcgcgcg ataaactcaa aatcagcaat aaagattggt tcgactttat ccagaataag     3780

cgctatctct aa                                                         3792


<210>  94
<211>  1263
<212>  PRT
<213>  Eubacterium rectale

<400>  94

Met Asn Asn Gly Thr Asn Asn Phe Gln Asn Phe Ile Gly Ile Ser Ser 
1               5                   10                  15      


Leu Gln Lys Thr Leu Arg Asn Ala Leu Ile Pro Thr Glu Thr Thr Gln 
            20                  25                  30          


Gln Phe Ile Val Lys Asn Gly Ile Ile Lys Glu Asp Glu Leu Arg Gly 
        35                  40                  45              


Glu Asn Arg Gln Ile Leu Lys Asp Ile Met Asp Asp Tyr Tyr Arg Gly 
    50                  55                  60                  


Phe Ile Ser Glu Thr Leu Ser Ser Ile Asp Asp Ile Asp Trp Thr Ser 
65                  70                  75                  80  


Leu Phe Glu Lys Met Glu Ile Gln Leu Lys Asn Gly Asp Asn Lys Asp 
                85                  90                  95      


Thr Leu Ile Lys Glu Gln Thr Glu Tyr Arg Lys Ala Ile His Lys Lys 
            100                 105                 110         


Phe Ala Asn Asp Asp Arg Phe Lys Asn Met Phe Ser Ala Lys Leu Ile 
        115                 120                 125             


Ser Asp Ile Leu Pro Glu Phe Val Ile His Asn Asn Asn Tyr Ser Ala 
    130                 135                 140                 


Ser Glu Lys Glu Glu Lys Thr Gln Val Ile Lys Leu Phe Ser Arg Phe 
145                 150                 155                 160 


Ala Thr Ser Phe Lys Asp Tyr Phe Lys Asn Arg Ala Asn Cys Phe Ser 
                165                 170                 175     


Ala Asp Asp Ile Ser Ser Ser Ser Cys His Arg Ile Val Asn Asp Asn 
            180                 185                 190         


Ala Glu Ile Phe Phe Ser Asn Ala Leu Val Tyr Arg Arg Ile Val Lys 
        195                 200                 205             


Ser Leu Ser Asn Asp Asp Ile Asn Lys Ile Ser Gly Asp Met Lys Asp 
    210                 215                 220                 


Ser Leu Lys Glu Met Ser Leu Glu Glu Ile Tyr Ser Tyr Glu Lys Tyr 
225                 230                 235                 240 


Gly Glu Phe Ile Thr Gln Glu Gly Ile Ser Phe Tyr Asn Asp Ile Cys 
                245                 250                 255     


Gly Lys Val Asn Ser Phe Met Asn Leu Tyr Cys Gln Lys Asn Lys Glu 
            260                 265                 270         


Asn Lys Asn Leu Tyr Lys Leu Gln Lys Leu His Lys Gln Ile Leu Cys 
        275                 280                 285             


Ile Ala Asp Thr Ser Tyr Glu Val Pro Tyr Lys Phe Glu Ser Asp Glu 
    290                 295                 300                 


Glu Val Tyr Gln Ser Val Asn Gly Phe Leu Asp Asn Ile Ser Ser Lys 
305                 310                 315                 320 


His Ile Val Glu Arg Leu Arg Lys Ile Gly Asp Asn Tyr Asn Gly Tyr 
                325                 330                 335     


Asn Leu Asp Lys Ile Tyr Ile Val Ser Lys Phe Tyr Glu Ser Val Ser 
            340                 345                 350         


Gln Lys Thr Tyr Arg Asp Trp Glu Thr Ile Asn Thr Ala Leu Glu Ile 
        355                 360                 365             


His Tyr Asn Asn Ile Leu Pro Gly Asn Gly Lys Ser Lys Ala Asp Lys 
    370                 375                 380                 


Val Lys Lys Ala Val Lys Asn Asp Leu Gln Lys Ser Ile Thr Glu Ile 
385                 390                 395                 400 


Asn Glu Leu Val Ser Asn Tyr Lys Leu Cys Ser Asp Asp Asn Ile Lys 
                405                 410                 415     


Ala Glu Thr Tyr Ile His Glu Ile Ser His Ile Leu Asn Asn Phe Glu 
            420                 425                 430         


Ala Gln Glu Leu Lys Tyr Asn Pro Glu Ile His Leu Val Glu Ser Glu 
        435                 440                 445             


Leu Lys Ala Ser Glu Leu Lys Asn Val Leu Asp Val Ile Met Asn Ala 
    450                 455                 460                 


Phe His Trp Cys Ser Val Phe Met Thr Glu Glu Leu Val Asp Lys Asp 
465                 470                 475                 480 


Asn Asn Phe Tyr Ala Glu Leu Glu Glu Ile Tyr Asp Glu Ile Tyr Pro 
                485                 490                 495     


Val Ile Ser Leu Tyr Asn Leu Val Arg Asn Tyr Val Thr Gln Lys Pro 
            500                 505                 510         


Tyr Ser Thr Lys Lys Ile Lys Leu Asn Phe Gly Ile Pro Thr Leu Ala 
        515                 520                 525             


Asp Gly Trp Ser Lys Ser Lys Glu Tyr Ser Asn Asn Ala Ile Ile Leu 
    530                 535                 540                 


Met Arg Asp Asn Leu Tyr Tyr Leu Gly Ile Phe Asn Ala Lys Asn Lys 
545                 550                 555                 560 


Pro Asp Lys Lys Ile Ile Glu Gly Asn Thr Ser Glu Asn Lys Gly Asp 
                565                 570                 575     


Tyr Lys Lys Met Ile Tyr Asn Leu Leu Pro Gly Pro Asn Lys Met Ile 
            580                 585                 590         


Pro Lys Val Phe Leu Ser Ser Lys Thr Gly Val Glu Thr Tyr Lys Pro 
        595                 600                 605             


Ser Ala Tyr Ile Leu Glu Gly Tyr Lys Gln Asn Lys His Ile Lys Ser 
    610                 615                 620                 


Ser Lys Asp Phe Asp Ile Thr Phe Cys His Asp Leu Ile Asp Tyr Phe 
625                 630                 635                 640 


Lys Asn Cys Ile Ala Ile His Pro Glu Trp Lys Asn Phe Gly Phe Asp 
                645                 650                 655     


Phe Ser Asp Thr Ser Thr Tyr Glu Asp Ile Ser Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Leu Gln Gly Tyr Lys Ile Asp Trp Thr Tyr Ile Ser Glu Lys 
        675                 680                 685             


Asp Ile Asp Leu Leu Gln Glu Lys Gly Gln Leu Tyr Leu Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Lys Lys Ser Thr Gly Asn Asp Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Leu Lys Asn Leu Phe Ser Glu Glu Asn Leu Lys Asp Ile 
                725                 730                 735     


Val Leu Lys Leu Asn Gly Glu Ala Glu Ile Phe Phe Arg Lys Ser Ser 
            740                 745                 750         


Ile Lys Asn Pro Ile Ile His Lys Lys Gly Ser Ile Leu Val Asn Arg 
        755                 760                 765             


Thr Tyr Glu Ala Glu Glu Lys Asp Gln Phe Gly Asn Ile Gln Ile Val 
    770                 775                 780                 


Arg Lys Asn Ile Pro Glu Asn Ile Tyr Gln Glu Leu Tyr Lys Tyr Phe 
785                 790                 795                 800 


Asn Asp Lys Ser Asp Lys Glu Leu Ser Asp Glu Ala Ala Lys Leu Lys 
                805                 810                 815     


Asn Val Val Gly His His Glu Ala Ala Thr Asn Ile Val Lys Asp Tyr 
            820                 825                 830         


Arg Tyr Thr Tyr Asp Lys Tyr Phe Leu His Met Pro Ile Thr Ile Asn 
        835                 840                 845             


Phe Lys Ala Asn Lys Thr Gly Phe Ile Asn Asp Arg Ile Leu Gln Tyr 
    850                 855                 860                 


Ile Ala Lys Glu Lys Asp Leu His Val Ile Gly Ile Asp Arg Gly Glu 
865                 870                 875                 880 


Arg Asn Leu Ile Tyr Val Ser Val Ile Asp Thr Cys Gly Asn Ile Val 
                885                 890                 895     


Glu Gln Lys Ser Phe Asn Ile Val Asn Gly Tyr Asp Tyr Gln Ile Lys 
            900                 905                 910         


Leu Lys Gln Gln Glu Gly Ala Arg Gln Ile Ala Arg Lys Glu Trp Lys 
        915                 920                 925             


Glu Ile Gly Lys Ile Lys Glu Ile Lys Glu Gly Tyr Leu Ser Leu Val 
    930                 935                 940                 


Ile His Glu Ile Ser Lys Met Val Ile Lys Tyr Asn Ala Ile Ile Ala 
945                 950                 955                 960 


Met Glu Asp Leu Ser Tyr Gly Phe Lys Lys Gly Arg Phe Lys Val Glu 
                965                 970                 975     


Arg Gln Val Tyr Gln Lys Phe Glu Thr Met Leu Ile Asn Lys Leu Asn 
            980                 985                 990         


Tyr Leu Val Phe Lys Asp Ile Ser  Ile Thr Glu Asn Gly  Gly Leu Leu 
        995                 1000                 1005             


Lys Gly  Tyr Gln Leu Thr Tyr  Ile Pro Asp Lys Leu  Lys Asn Val 
    1010                 1015                 1020             


Gly His  Gln Cys Gly Cys Ile  Phe Tyr Val Pro Ala  Ala Tyr Thr 
    1025                 1030                 1035             


Ser Lys  Ile Asp Pro Thr Thr  Gly Phe Val Asn Ile  Phe Lys Phe 
    1040                 1045                 1050             


Lys Asp  Leu Thr Val Asp Ala  Lys Arg Glu Phe Ile  Lys Lys Phe 
    1055                 1060                 1065             


Asp Ser  Ile Arg Tyr Asp Ser  Glu Lys Asn Leu Phe  Cys Phe Thr 
    1070                 1075                 1080             


Phe Asp  Tyr Asn Asn Phe Ile  Thr Gln Asn Thr Val  Met Ser Lys 
    1085                 1090                 1095             


Ser Ser  Trp Ser Val Tyr Thr  Tyr Gly Val Arg Ile  Lys Arg Arg 
    1100                 1105                 1110             


Phe Val  Asn Gly Arg Phe Ser  Asn Glu Ser Asp Thr  Ile Asp Ile 
    1115                 1120                 1125             


Thr Lys  Asp Met Glu Lys Thr  Leu Glu Met Thr Asp  Ile Asn Trp 
    1130                 1135                 1140             


Arg Asp  Gly His Asp Leu Arg  Gln Asp Ile Ile Asp  Tyr Glu Ile 
    1145                 1150                 1155             


Val Gln  His Ile Phe Glu Ile  Phe Arg Leu Thr Val  Gln Met Arg 
    1160                 1165                 1170             


Asn Ser  Leu Ser Glu Leu Glu  Asp Arg Asp Tyr Asp  Arg Leu Ile 
    1175                 1180                 1185             


Ser Pro  Val Leu Asn Glu Asn  Asn Ile Phe Tyr Asp  Ser Ala Lys 
    1190                 1195                 1200             


Ala Gly  Asp Ala Leu Pro Lys  Asp Ala Asp Ala Asn  Gly Ala Tyr 
    1205                 1210                 1215             


Cys Ile  Ala Leu Lys Gly Leu  Tyr Glu Ile Lys Gln  Ile Thr Glu 
    1220                 1225                 1230             


Asn Trp  Lys Glu Asp Gly Lys  Phe Ser Arg Asp Lys  Leu Lys Ile 
    1235                 1240                 1245             


Ser Asn  Lys Asp Trp Phe Asp  Phe Ile Gln Asn Lys  Arg Tyr Leu 
    1250                 1255                 1260             


<210>  95
<211>  3816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Sequence

<400>  95
atgaacaacg gcacaaacaa cttccagaac ttcattggaa tctcgtcgtt gcagaagact       60

ttgcgcaacg ccctcatccc cacagaaact acccagcagt tcattgtgaa gaacggaatc      120

atcaaggaag atgaactccg aggcgagaac cgccagattt tgaaggacat catggatgat      180

tactaccgtg gtttcatctc ggaaacgctc tcctccattg acgacatcga ttggacttcg      240

ttgttcgaaa agatggaaat ccagctcaaa aacggcgata acaaggatac cttgatcaag      300

gagcagaccg agtatcggaa ggcgatccat aagaagttcg ccaacgatga tcggttcaag      360

aacatgttct cggccaagtt gatttccgac attctccccg aattcgtgat ccataacaac      420

aactactcgg cgtcggagaa ggaggagaag acgcaggtca tcaagttgtt ctcgaggttc      480

gccacatcgt tcaaagacta ttttaagaat cgtgcgaact gtttctcggc agatgatatc      540

tcctcgtcct cctgtcaccg cattgtgaac gacaacgcgg aaatcttctt ctcgaacgcg      600

ttggtgtata ggcgcatcgt gaagtccctc tccaacgatg acatcaacaa aatctcggga      660

gatatgaagg attcgctcaa ggagatgtcg ttggaggaaa tctactccta tgagaagtat      720

ggcgagttca ttacgcagga gggcatttcc ttctacaacg acatttgtgg taaagtcaac      780

tcgttcatga acctctactg tcagaaaaac aaggagaaca aaaacctcta taagctccag      840

aagttgcata agcagatcct ctgtatcgca gacacctcgt acgaggtccc ttacaagttc      900

gaatccgatg aggaggtcta ccagtccgtc aacggattct tggacaacat ctcctcgaaa      960

cacattgtcg agcggctccg aaagatcggc gataactaca acggctacaa cttggacaaa     1020

atctatatcg tctccaagtt ctatgagtcc gtctcgcaga aaacctatcg tgattgggag     1080

actatcaaca ctgcgctcga gattcactat aacaacatct tgcctggtaa cggcaaatcg     1140

aaagccgaca aggtgaagaa ggccgtgaaa aacgatctcc agaagtcgat cacagaaatc     1200

aacgaactcg tctcgaacta caagctctgt tcggatgata acatcaaggc ggaaacgtac     1260

atccatgaaa tctcgcatat cttgaacaac ttcgaggccc aggaactcaa atacaacccc     1320

gagatccact tggtcgagtc ggagctcaaa gcctcggagt tgaagaacgt cttggatgtc     1380

atcatgaacg cattccactg gtgttccgtg ttcatgaccg aggaactcgt cgataaagac     1440

aacaacttct acgcggaact cgaggaaatc tacgatgaaa tctatcccgt gatctccctc     1500

tacaacctcg tgcgaaacta cgtcactcag aagccctatt ccaccaagaa gatcaagctc     1560

aacttcggca tccccactct cgcagacggt tggtcgaagt cgaaggagta ctccaacaac     1620

gccattatcc tcatgcgaga caacctctac tacttgggta tcttcaacgc aaagaacaag     1680

ccggataaga agatcattga aggcaacact tcggaaaaca agggagacta taagaagatg     1740

atctacaacc tcctccctgg acccaacaag atgattccta aagtgttcct ctcgtcgaag     1800

actggtgtgg aaacgtataa gccgtcggcc tacatcttgg agggctacaa acagaacaag     1860

catatcaagt cctcgaagga cttcgacatc actttctgtc acgacctcat cgactatttc     1920

aagaactgta ttgcaatcca tccggaatgg aagaacttcg gcttcgattt ctcggatact     1980

tcgacatacg aagatatctc gggattctac cgagaggtcg aattgcaggg ctataagatt     2040

gattggacct acatctcgga aaaggatatc gacttgctcc aggaaaaggg ccagctctac     2100

ctcttccaga tttacaacaa ggacttctcc aagaagtcga cgggtaacga caacttgcac     2160

acaatgtatc tcaaaaacct cttctcggag gagaacttga aggatatcgt gctcaaattg     2220

aacggagagg ccgaaatctt cttccgtaag tcctccatca agaacccgat catccataag     2280

aagggatcga tcttggtcaa ccggacttac gaagcagagg aaaaagatca gttcggaaac     2340

atccagattg tcaggaagaa catccctgaa aacatctatc aggagttgta taagtacttc     2400

aacgacaagt cggataagga gctctccgac gaagcagcca aactcaagaa cgtcgtcgga     2460

caccatgaag cagcaaccaa cattgtgaag gactaccggt acacttacga caagtacttc     2520

ttgcacatgc cgatcactat caacttcaaa gccaacaaga ccggattcat taacgacagg     2580

atcctccagt acattgccaa agaaaaggac ctccatgtca tcggtatcga taggggagaa     2640

cggaacctca tctacgtctc cgtgattgac acttgtggca acattgtcga acagaagtcg     2700

ttcaacatcg tcaacggtta cgattaccag attaagttga aacagcagga aggtgcgagg     2760

cagattgcgc gaaaggaatg gaaggagatt ggcaaaatca aggagattaa ggaaggctac     2820

ttgtcgttgg tcatccacga aatctcgaaa atggtgatca aatacaacgc catcatcgcc     2880

atggaagacc tctcgtacgg cttcaaaaag ggacggttca aagtggagcg tcaggtgtac     2940

cagaagttcg aaacaatgtt gatcaacaag ttgaactact tggtgttcaa ggacatttcc     3000

attaccgaga acggaggatt gctcaagggt tatcagctca cgtacatccc cgacaagttg     3060

aaaaacgtgg gacaccagtg tggctgtatc ttctacgtgc ctgcagccta cacgtcgaaa     3120

atcgacccta caacaggatt cgtgaacatc ttcaagttca aggatctcac cgtcgacgcg     3180

aagcgggagt tcatcaaaaa gttcgactcc atccgctatg attcggagaa gaacttgttc     3240

tgtttcacat tcgactacaa caacttcatt actcagaaca ccgtgatgtc caaatcgtcg     3300

tggtccgtgt acacgtatgg tgtgcgcatc aaaaggcgct tcgtcaacgg tcgcttctcc     3360

aacgaatcgg acacgatcga tatcacgaaa gacatggaga aaacattgga aatgaccgac     3420

atcaactggc gtgacggcca tgacctcagg caggacatca tcgattacga gatcgtccag     3480

cacatcttcg aaatcttccg tctcaccgtg cagatgagga actccctctc cgagctcgaa     3540

gatcgggatt acgaccggct catttcccct gtgttgaacg agaacaacat cttctacgac     3600

tcggcaaaag cgggagatgc attgccgaag gacgccgatg cgaacggtgc atattgtatt     3660

gcactcaagg gtctctacga aatcaagcag atcaccgaaa actggaagga ggacggcaaa     3720

ttctcgaggg acaagttgaa gatttcgaac aaggattggt tcgatttcat ccagaacaag     3780

aggtacttgc ctccgaagaa gaagcgaaag gtgtga                               3816


<210>  96
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  96
tagtttctgc catttgcaat cgagacagca gaatcaccg                              39


<210>  97
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  97
gctatgacca tgattacgcc atcctgccct cttgctcaat                             40


<210>  98
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  98
gagtcgacct gcaggcatgc aagctttctg ctcgaggcca tctggctt                    48


<210>  99
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  99
aattaaaaag gtcttttgac tgcatcatcc gtgaatcgaa cacgg                       45


<210>  100
<211>  311
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Sequence

<400>  100
ttcgattcac ggatgatgca gtcaaaagac ctttttaatt tctactcttg tagatctaca       60

acacgtcctc gagggttttt tttggctctt gggttcgaac tgcccaaggc ccatgttttg      120

gtcatctttt tttttatgcc ccaccatttg ggtcacccct gccaatcatt ccatctttgt      180

tcctaccctt cacgtgtgct ttccgaagcc aaagttccca ttcaacaact ctccttgcgt      240

tttttttttc ttgaagcttg tcacccgtcg atagtttctg ccatttgcaa tcgagacagc      300

agaatcaccg c                                                           311


<210>  101
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  101
gccacatcgt tcaaagacta ttttaagaat cgtgc                                  35


<210>  102
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  102
atttgtggta aagtcaactc gttcatgaac ctc                                    33


<210>  103
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  103
aaaactggaa ggaggacggc aaattctcga gg                                     32


<210>  104
<211>  3924
<212>  DNA
<213>  Acidaminococcus sp.

<400>  104
atgacccaat ttgaaggttt taccaattta taccaagttt cgaagaccct tcgttttgaa       60

ctgattcccc aaggaaaaac actcaaacat atccaggagc aagggttcat tgaggaggat      120

aaagctcgca atgaccatta caaagagtta aaaccaatca ttgaccgcat ctataagact      180

tatgctgatc aatgtctcca actggtacag cttgactggg agaatctatc tgcagccata      240

gactcctatc gtaaggaaaa aaccgaagaa acacgaaatg cgctgattga ggagcaagca      300

acatatagaa atgcgattca tgactacttt ataggtcgga cggataatct gacagatgcc      360

ataaataagc gccatgctga aatctataaa ggacttttta aagctgaact tttcaatgga      420

aaagttttaa agcaattagg gaccgtaacc acgacagaac atgaaaatgc tctactccgt      480

tcgtttgaca aatttacgac ctatttttcc ggcttttatg aaaaccgaaa aaatgtcttt      540

agcgctgaag atatcagcac ggcaattccc catcgaatcg tccaggacaa tttccctaaa      600

tttaaggaaa actgccatat ttttacaaga ttgataaccg cagttccttc tttgcgggag      660

cattttgaaa atgtcaaaaa ggccattgga atctttgtta gtacgtctat tgaagaagtc      720

ttttcctttc ccttttataa tcaacttcta acccaaacgc aaattgatct ttataatcaa      780

cttctcggcg gcatatctag ggaagcaggc acagaaaaaa tcaagggact taatgaagtt      840

ctcaatctgg ctatccaaaa aaatgatgaa acagcccata taatcgcgtc cctgccgcat      900

cgttttattc ctctttttaa acaaattctt tccgatcgaa atacgttatc ctttattttg      960

gaagaattca aaagcgatga ggaagtcatc caatccttct gcaaatataa aaccctcttg     1020

agaaacgaaa atgtactgga gactgcagaa gcccttttca atgaattaaa ttccattgat     1080

ttgactcata tctttatttc ccataaaaag ttagaaacca tctcttcagc gctttgtgac     1140

cattgggata ccttgcgcaa tgcactttac gaaagacgga tttctgaact cactggcaaa     1200

ataacaaaaa gtgccaaaga aaaagttcaa aggtcattaa aacatgagga tataaatctc     1260

caagaaatta tttctgctgc aggaaaagaa ctatcagaag cattcaaaca aaaaacaagt     1320

gaaattcttt cccatgccca tgctgcactt gaccagcctc ttcccacaac attaaaaaaa     1380

caggaagaaa aagaaatcct caaatcacag ctcgattcgc ttttaggcct ttatcatctt     1440

cttgattggt ttgctgtcga tgaaagcaat gaagtcgacc cagaattctc agcacggctg     1500

acaggcatta aactagaaat ggaaccaagc ctttcgtttt ataataaagc aagaaattat     1560

gcgacaaaaa agccctattc ggtggaaaaa tttaaattga attttcaaat gccaaccctt     1620

gcctctggtt gggatgtcaa taaagaaaaa aataatggag ctattttatt cgtaaaaaat     1680

ggtctctatt accttggtat catgcctaaa cagaaggggc gctataaagc cctgtctttt     1740

gagccgacag aaaaaacatc agaaggattc gataagatgt actatgacta cttcccagat     1800

gccgcaaaaa tgattcctaa gtgttccact cagctaaagg ctgtaaccgc tcattttcaa     1860

actcatacca cccccattct tctctcaaat aatttcattg aacctcttga aatcacaaaa     1920

gaaatttatg acctgaacaa tcctgaaaag gagcctaaaa agtttcaaac ggcttatgca     1980

aagaagacag gcgatcaaaa aggctataga gaagcgcttt gcaaatggat tgactttacg     2040

cgggattttc tctctaaata tacgaaaaca acttcaatcg atttatcttc actccgccct     2100

tcttcgcaat ataaagattt aggggaatat tacgccgaac tgaatccgct tctctatcat     2160

atctccttcc aacgaattgc tgaaaaggaa atcatggatg ctgtagaaac gggaaaattg     2220

tatctgttcc aaatctacaa taaggatttt gcgaagggcc atcacgggaa accaaatctc     2280

cacaccctgt attggacagg tctcttcagt cctgaaaacc ttgcgaaaac cagcatcaaa     2340

cttaatggtc aagcagaatt gttctatcga cctaaaagcc gcatgaagcg gatggcccat     2400

cgtcttgggg aaaaaatgct gaacaaaaaa ctaaaggacc agaagacacc gattccagat     2460

accctctacc aagaactgta cgattatgtc aaccaccggc taagccatga tctttccgat     2520

gaagcaaggg ccctgcttcc aaatgttatc accaaagaag tctcccatga aattataaag     2580

gatcggcggt ttacttccga taaatttttc ttccatgttc ccattacact gaattatcaa     2640

gcagccaata gtcccagtaa attcaaccag cgtgtcaatg cctaccttaa ggagcatccg     2700

gaaacgccca tcattggtat cgatcgtgga gaacgcaatc taatctatat taccgtcatt     2760

gacagtactg ggaaaatttt ggagcagcgt tccctgaata ccatccagca atttgactac     2820

caaaaaaaat tggacaacag ggaaaaagag cgtgttgccg cccgtcaagc ctggtccgtc     2880

gtcggaacga tcaaagacct taaacaaggc tacttgtcac aggtcatcca tgaaattgta     2940

gacctgatga ttcattacca agctgttgtc gtccttgaaa acctcaactt cggatttaaa     3000

tcaaaacgga caggcattgc cgaaaaagca gtctaccaac aatttgaaaa gatgctaata     3060

gataaactca actgtttggt tctcaaagat tatcctgctg agaaagtggg aggcgtctta     3120

aacccgtatc aacttacaga tcagttcacg agctttgcaa aaatgggcac gcaaagcggc     3180

ttccttttct atgtaccggc cccttatacc tcaaagattg atcccctgac tggttttgtc     3240

gatccctttg tatggaagac cattaaaaat catgaaagtc ggaagcattt cctagaagga     3300

tttgatttcc tgcattatga tgtcaaaaca ggtgatttta tcctccattt taaaatgaat     3360

cggaatctct ctttccagag agggcttcct ggcttcatgc cagcttggga tattgttttc     3420

gaaaagaatg aaacccaatt tgatgcaaaa gggacgccct tcattgcagg aaaacgaatt     3480

gttcctgtaa tcgaaaatca tcgttttacg ggtcgttaca gagacctcta tcccgctaat     3540

gaactcattg cccttctgga agaaaaaggc attgtcttta gagacggaag taatatatta     3600

cccaaacttt tagaaaatga tgattctcat gcaattgata cgatggtcgc cttgattcgc     3660

agtgtactcc aaatgagaaa cagcaatgcc gcaacggggg aagactacat caactctccc     3720

gttagggatc tgaacggggt gtgtttcgac agtcgattcc aaaatccaga atggccaatg     3780

gatgcggatg ccaacggagc ttatcatatt gccttaaaag ggcagcttct tctgaaccac     3840

ctcaaagaaa gcaaagatct gaaattacaa aacggcatca gcaaccaaga ttggctggcc     3900

tacattcagg aactgagaaa ctga                                            3924


<210>  105
<211>  1307
<212>  PRT
<213>  Acidaminococcus sp.

<400>  105

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  106
<211>  3693
<212>  DNA
<213>  Lachnospiraceae sp.

<400>  106
atgcatgaga acaatggaaa aatagcagat aatttcattg gaatatatcc tgtatcaaaa       60

accttgcgtt ttgaactaaa accagtcgga aaaacacaag agtatattga gaaacatgga      120

atattggatg aagacttaaa acgggcgggg gactataaga gcgtaaaaaa aataattgac      180

gcttatcaca aatatttcat tgatgaggca ttaaatggaa ttcaattaga cgggttaaaa      240

aattattatg aactgtatga gaaaaaacgt gacaataatg aagagaaaga gtttcagaaa      300

atacagatgt cattgcgtaa acagattgta aagagatttt ctgaacatcc acaatacaaa      360

tacttattta aaaaggaact gattaaaaat gtcctgcctg aatttacaaa agataatgca      420

gaagagcaga ctctagtaaa gtcatttcag gagtttacaa catactttga aggttttcat      480

caaaatagaa aaaatatgta ttctgatgaa gaaaaatcaa cagctattgc gtatcgcgtt      540

gtacatcaaa atctgcccaa atatattgat aatatgcgta tattttccat gatattaaat      600

acggatatac ggagtgattt gacagaatta ttcaataatt tgaaaaccaa aatggatata      660

actatagtag aagaatattt tgcaattgat ggattcaata aggtagttaa tcaaaaggga      720

attgatgtct ataatacaat tttaggcgct tttagcactg atgataatac gaagataaaa      780

ggtctgaatg agtatatcaa tttgtataac caaaagaata aggcaaaact gccaaagctg      840

aaaccgcttt ttaaacaaat tttaagtgat agggataaaa tatcttttat tccggaacag      900

tttgattcag atacagaagt tttagaagcg gttgatatgt tctacaatag attactgcag      960

tttgtgattg agaatgaagg gcagataact ataagcaaac ttctaacaaa tttttcggca     1020

tatgacttga ataaaatata tgtaaaaaat gatacgacaa tatctgcaat atcaaatgat     1080

ttatttgatg attggtcata tataagtaaa gcggttcggg aaaactatga ttcagaaaat     1140

gttgataaaa ataagcgggc agcagcttat gaggaaaaga aagagaaagc gctttcaaaa     1200

attaagatgt attctataga agagttaaat ttctttgtta agaaatattc atgcaatgag     1260

tgccatatcg agggatattt tgaacggaga atcttagaaa ttcttgataa aatgcgttat     1320

gcatatgaat catgtaaaat tttgcatgat aagggattga taaacaacat atcattatgt     1380

caagacaggc aggcgatttc agagttgaaa gatttcttag attcaataaa agaagtgcaa     1440

tggctgttaa aaccgcttat gattgggcag gagcaagcag ataaagagga agcattttat     1500

acagaacttt tacggatatg ggaagaactt gaaccgatta cgctgctgta taataaagtg     1560

cgtaattatg tgacgaaaaa gccttataca ttggaaaaag tgaaattaaa cttttataag     1620

tctacattat tagatggatg ggataaaaac aaagaaaaag ataaccttgg aatcatttta     1680

ttaaaagacg gtcaatatta cttgggaatt atgaaccgaa ggaacaataa aatagcagat     1740

gatgccccct tggctaaaac ggataatgta tacaggaaaa tggaatataa attattaacc     1800

aaagtaagtg caaatctgcc tcggatattt cttaaagata aatacaaccc atcggaagag     1860

atgctggaaa agtacgaaaa gggtacacat ttaaaaggcg aaaacttctg catagatgat     1920

tgcagggaat taatagactt ttttaagaaa ggcatcaagc aatatgaaga ttgggggcaa     1980

tttgatttta agttttccga tacggaatca tatgatgata ttagtgcgtt ttataaagag     2040

gtagagcatc agggatacaa aataacattt agagatattg atgaaacata tattgatagt     2100

ttggtaaatg agggaaaact ttatctgttt caaatatata ataaagactt ttcgccgtat     2160

agtaaaggaa caaaaaatct gcatacgtta tactgggaga tgctgttttc acaacagaat     2220

ctacaaaata tcgtatataa attaaatgga aatgcggaaa tattttatag aaaggcaagc     2280

attaatcaaa aagatgttgt cgtacataag gcggatttac ctataaaaaa taaggatccg     2340

caaaatagta aaaaagaaag tatgtttgac tatgacataa taaaagataa acgttttacc     2400

tgcgataaat accaattcca tgtaccaatt acaatgaatt tcaaagcgct aggtgagaat     2460

cattttaatc gcaaggtaaa ccgtttgatt catgatgctg aaaatatgca tattatagga     2520

attgacagag gagaacgaaa tcttatatat ttgtgtatga tagacatgaa gggaaacatt     2580

gtaaagcaaa tatcattaaa tgagataatt tcttatgata aaaacaaatt ggaacacaaa     2640

agaaattatc atcaattgtt aaaaacacgg gaagatgaaa ataaaagcgc acgtcagagc     2700

tggcagacca ttcatacaat caaagagtta aaggaaggat acctcagtca ggtaattcat     2760

gttataacgg acttaatggt ggaatataat gcgattgtag ttttggaaga tttaaatttt     2820

ggttttaagc aaggaaggca gaaatttgaa aggcaggtat accaaaaatt tgagaaaatg     2880

ttgattgata aattgaatta tcttgtagat aaatcaaaag gcatggacga agatggaggg     2940

ctgctccatg cataccaact tacggatgaa ttcaaaagct ttaagcagtt gggaaaacaa     3000

tcgggttttc tttactatat tcccgcatgg aataccagca aattagatcc gacaacagga     3060

tttgttaatt tattttatac gaaatatgag tctgttgaaa aatcaaagga atttattaat     3120

aattttacct caatattata taatcaggaa cgggaatatt ttgaattttt atttgattat     3180

tccgctttta cttccaaagc agagggaagc agactgaaat ggacagtgtg ttctaaagga     3240

gaacgagttg aaacctatag aaatcccaag aagaacaacg aatgggatac gcaaaagata     3300

gatttaactt tcgaattgaa aaaattgttc aatgattata gtatttccct tttggatggc     3360

gacttacgtg aacaaatggg aaaaattgat aaagcagatt tctataaaaa atttatgaaa     3420

ctgttcgcat tgattgtaca gatgcggaat agtgatgagc gggaagataa gttaatatct     3480

ccagtattaa ataaatatgg tgcgtttttt gaaacgggta agaatgaaag aatgccttta     3540

gatgcggatg cgaatggcgc gtataatatt gcacgaaaag gtctttggat tattgagaaa     3600

attaaaaata cggatgtaga acaactggat aaggtaaaac ttacaatatc taataaagaa     3660

tggttacagt atgcacagga acatatatta taa                                  3693


<210>  107
<211>  1230
<212>  PRT
<213>  Lachnospiraceae sp.

<400>  107

Met His Glu Asn Asn Gly Lys Ile Ala Asp Asn Phe Ile Gly Ile Tyr 
1               5                   10                  15      


Pro Val Ser Lys Thr Leu Arg Phe Glu Leu Lys Pro Val Gly Lys Thr 
            20                  25                  30          


Gln Glu Tyr Ile Glu Lys His Gly Ile Leu Asp Glu Asp Leu Lys Arg 
        35                  40                  45              


Ala Gly Asp Tyr Lys Ser Val Lys Lys Ile Ile Asp Ala Tyr His Lys 
    50                  55                  60                  


Tyr Phe Ile Asp Glu Ala Leu Asn Gly Ile Gln Leu Asp Gly Leu Lys 
65                  70                  75                  80  


Asn Tyr Tyr Glu Leu Tyr Glu Lys Lys Arg Asp Asn Asn Glu Glu Lys 
                85                  90                  95      


Glu Phe Gln Lys Ile Gln Met Ser Leu Arg Lys Gln Ile Val Lys Arg 
            100                 105                 110         


Phe Ser Glu His Pro Gln Tyr Lys Tyr Leu Phe Lys Lys Glu Leu Ile 
        115                 120                 125             


Lys Asn Val Leu Pro Glu Phe Thr Lys Asp Asn Ala Glu Glu Gln Thr 
    130                 135                 140                 


Leu Val Lys Ser Phe Gln Glu Phe Thr Thr Tyr Phe Glu Gly Phe His 
145                 150                 155                 160 


Gln Asn Arg Lys Asn Met Tyr Ser Asp Glu Glu Lys Ser Thr Ala Ile 
                165                 170                 175     


Ala Tyr Arg Val Val His Gln Asn Leu Pro Lys Tyr Ile Asp Asn Met 
            180                 185                 190         


Arg Ile Phe Ser Met Ile Leu Asn Thr Asp Ile Arg Ser Asp Leu Thr 
        195                 200                 205             


Glu Leu Phe Asn Asn Leu Lys Thr Lys Met Asp Ile Thr Ile Val Glu 
    210                 215                 220                 


Glu Tyr Phe Ala Ile Asp Gly Phe Asn Lys Val Val Asn Gln Lys Gly 
225                 230                 235                 240 


Ile Asp Val Tyr Asn Thr Ile Leu Gly Ala Phe Ser Thr Asp Asp Asn 
                245                 250                 255     


Thr Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys 
            260                 265                 270         


Asn Lys Ala Lys Leu Pro Lys Leu Lys Pro Leu Phe Lys Gln Ile Leu 
        275                 280                 285             


Ser Asp Arg Asp Lys Ile Ser Phe Ile Pro Glu Gln Phe Asp Ser Asp 
    290                 295                 300                 


Thr Glu Val Leu Glu Ala Val Asp Met Phe Tyr Asn Arg Leu Leu Gln 
305                 310                 315                 320 


Phe Val Ile Glu Asn Glu Gly Gln Ile Thr Ile Ser Lys Leu Leu Thr 
                325                 330                 335     


Asn Phe Ser Ala Tyr Asp Leu Asn Lys Ile Tyr Val Lys Asn Asp Thr 
            340                 345                 350         


Thr Ile Ser Ala Ile Ser Asn Asp Leu Phe Asp Asp Trp Ser Tyr Ile 
        355                 360                 365             


Ser Lys Ala Val Arg Glu Asn Tyr Asp Ser Glu Asn Val Asp Lys Asn 
    370                 375                 380                 


Lys Arg Ala Ala Ala Tyr Glu Glu Lys Lys Glu Lys Ala Leu Ser Lys 
385                 390                 395                 400 


Ile Lys Met Tyr Ser Ile Glu Glu Leu Asn Phe Phe Val Lys Lys Tyr 
                405                 410                 415     


Ser Cys Asn Glu Cys His Ile Glu Gly Tyr Phe Glu Arg Arg Ile Leu 
            420                 425                 430         


Glu Ile Leu Asp Lys Met Arg Tyr Ala Tyr Glu Ser Cys Lys Ile Leu 
        435                 440                 445             


His Asp Lys Gly Leu Ile Asn Asn Ile Ser Leu Cys Gln Asp Arg Gln 
    450                 455                 460                 


Ala Ile Ser Glu Leu Lys Asp Phe Leu Asp Ser Ile Lys Glu Val Gln 
465                 470                 475                 480 


Trp Leu Leu Lys Pro Leu Met Ile Gly Gln Glu Gln Ala Asp Lys Glu 
                485                 490                 495     


Glu Ala Phe Tyr Thr Glu Leu Leu Arg Ile Trp Glu Glu Leu Glu Pro 
            500                 505                 510         


Ile Thr Leu Leu Tyr Asn Lys Val Arg Asn Tyr Val Thr Lys Lys Pro 
        515                 520                 525             


Tyr Thr Leu Glu Lys Val Lys Leu Asn Phe Tyr Lys Ser Thr Leu Leu 
    530                 535                 540                 


Asp Gly Trp Asp Lys Asn Lys Glu Lys Asp Asn Leu Gly Ile Ile Leu 
545                 550                 555                 560 


Leu Lys Asp Gly Gln Tyr Tyr Leu Gly Ile Met Asn Arg Arg Asn Asn 
                565                 570                 575     


Lys Ile Ala Asp Asp Ala Pro Leu Ala Lys Thr Asp Asn Val Tyr Arg 
            580                 585                 590         


Lys Met Glu Tyr Lys Leu Leu Thr Lys Val Ser Ala Asn Leu Pro Arg 
        595                 600                 605             


Ile Phe Leu Lys Asp Lys Tyr Asn Pro Ser Glu Glu Met Leu Glu Lys 
    610                 615                 620                 


Tyr Glu Lys Gly Thr His Leu Lys Gly Glu Asn Phe Cys Ile Asp Asp 
625                 630                 635                 640 


Cys Arg Glu Leu Ile Asp Phe Phe Lys Lys Gly Ile Lys Gln Tyr Glu 
                645                 650                 655     


Asp Trp Gly Gln Phe Asp Phe Lys Phe Ser Asp Thr Glu Ser Tyr Asp 
            660                 665                 670         


Asp Ile Ser Ala Phe Tyr Lys Glu Val Glu His Gln Gly Tyr Lys Ile 
        675                 680                 685             


Thr Phe Arg Asp Ile Asp Glu Thr Tyr Ile Asp Ser Leu Val Asn Glu 
    690                 695                 700                 


Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Pro Tyr 
705                 710                 715                 720 


Ser Lys Gly Thr Lys Asn Leu His Thr Leu Tyr Trp Glu Met Leu Phe 
                725                 730                 735     


Ser Gln Gln Asn Leu Gln Asn Ile Val Tyr Lys Leu Asn Gly Asn Ala 
            740                 745                 750         


Glu Ile Phe Tyr Arg Lys Ala Ser Ile Asn Gln Lys Asp Val Val Val 
        755                 760                 765             


His Lys Ala Asp Leu Pro Ile Lys Asn Lys Asp Pro Gln Asn Ser Lys 
    770                 775                 780                 


Lys Glu Ser Met Phe Asp Tyr Asp Ile Ile Lys Asp Lys Arg Phe Thr 
785                 790                 795                 800 


Cys Asp Lys Tyr Gln Phe His Val Pro Ile Thr Met Asn Phe Lys Ala 
                805                 810                 815     


Leu Gly Glu Asn His Phe Asn Arg Lys Val Asn Arg Leu Ile His Asp 
            820                 825                 830         


Ala Glu Asn Met His Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu 
        835                 840                 845             


Ile Tyr Leu Cys Met Ile Asp Met Lys Gly Asn Ile Val Lys Gln Ile 
    850                 855                 860                 


Ser Leu Asn Glu Ile Ile Ser Tyr Asp Lys Asn Lys Leu Glu His Lys 
865                 870                 875                 880 


Arg Asn Tyr His Gln Leu Leu Lys Thr Arg Glu Asp Glu Asn Lys Ser 
                885                 890                 895     


Ala Arg Gln Ser Trp Gln Thr Ile His Thr Ile Lys Glu Leu Lys Glu 
            900                 905                 910         


Gly Tyr Leu Ser Gln Val Ile His Val Ile Thr Asp Leu Met Val Glu 
        915                 920                 925             


Tyr Asn Ala Ile Val Val Leu Glu Asp Leu Asn Phe Gly Phe Lys Gln 
    930                 935                 940                 


Gly Arg Gln Lys Phe Glu Arg Gln Val Tyr Gln Lys Phe Glu Lys Met 
945                 950                 955                 960 


Leu Ile Asp Lys Leu Asn Tyr Leu Val Asp Lys Ser Lys Gly Met Asp 
                965                 970                 975     


Glu Asp Gly Gly Leu Leu His Ala Tyr Gln Leu Thr Asp Glu Phe Lys 
            980                 985                 990         


Ser Phe Lys Gln Leu Gly Lys Gln  Ser Gly Phe Leu Tyr  Tyr Ile Pro 
        995                 1000                 1005             


Ala Trp  Asn Thr Ser Lys Leu  Asp Pro Thr Thr Gly  Phe Val Asn 
    1010                 1015                 1020             


Leu Phe  Tyr Thr Lys Tyr Glu  Ser Val Glu Lys Ser  Lys Glu Phe 
    1025                 1030                 1035             


Ile Asn  Asn Phe Thr Ser Ile  Leu Tyr Asn Gln Glu  Arg Glu Tyr 
    1040                 1045                 1050             


Phe Glu  Phe Leu Phe Asp Tyr  Ser Ala Phe Thr Ser  Lys Ala Glu 
    1055                 1060                 1065             


Gly Ser  Arg Leu Lys Trp Thr  Val Cys Ser Lys Gly  Glu Arg Val 
    1070                 1075                 1080             


Glu Thr  Tyr Arg Asn Pro Lys  Lys Asn Asn Glu Trp  Asp Thr Gln 
    1085                 1090                 1095             


Lys Ile  Asp Leu Thr Phe Glu  Leu Lys Lys Leu Phe  Asn Asp Tyr 
    1100                 1105                 1110             


Ser Ile  Ser Leu Leu Asp Gly  Asp Leu Arg Glu Gln  Met Gly Lys 
    1115                 1120                 1125             


Ile Asp  Lys Ala Asp Phe Tyr  Lys Lys Phe Met Lys  Leu Phe Ala 
    1130                 1135                 1140             


Leu Ile  Val Gln Met Arg Asn  Ser Asp Glu Arg Glu  Asp Lys Leu 
    1145                 1150                 1155             


Ile Ser  Pro Val Leu Asn Lys  Tyr Gly Ala Phe Phe  Glu Thr Gly 
    1160                 1165                 1170             


Lys Asn  Glu Arg Met Pro Leu  Asp Ala Asp Ala Asn  Gly Ala Tyr 
    1175                 1180                 1185             


Asn Ile  Ala Arg Lys Gly Leu  Trp Ile Ile Glu Lys  Ile Lys Asn 
    1190                 1195                 1200             


Thr Asp  Val Glu Gln Leu Asp  Lys Val Lys Leu Thr  Ile Ser Asn 
    1205                 1210                 1215             


Lys Glu  Trp Leu Gln Tyr Ala  Gln Glu His Ile Leu  
    1220                 1225                 1230 


<210>  108
<211>  3903
<212>  DNA
<213>  Francisella novicida

<400>  108
atgtcaattt atcaagaatt tgttaataaa tatagtttaa gtaaaactct aagatttgag       60

ttaatcccac agggtaaaac acttgaaaac ataaaagcaa gaggtttgat tttagatgat      120

gagaaaagag ctaaagacta caaaaaggct aaacaaataa ttgataaata tcatcagttt      180

tttatagagg agatattaag ttcggtttgt attagcgaag atttattaca aaactattct      240

gatgtttatt ttaaacttaa aaagagtgat gatgataatc tacaaaaaga ttttaaaagt      300

gcaaaagata cgataaagaa acaaatatct gaatatataa aggactcaga gaaatttaag      360

aatttgttta atcaaaacct tatcgatgct aaaaaagggc aagagtcaga tttaattcta      420

tggctaaagc aatctaagga taatggtata gaactattta aagccaatag tgatatcaca      480

gatatagatg aggcgttaga aataatcaaa tcttttaaag gttggacaac ttattttaag      540

ggttttcatg aaaatagaaa aaatgtttat agtagcaatg atattcctac atctattatt      600

tataggatag tagatgataa tttgcctaaa tttctagaaa ataaagctaa gtatgagagt      660

ttaaaagaca aagctccaga agctataaac tatgaacaaa ttaaaaaaga tttggcagaa      720

gagctaacct ttgatattga ctacaaaaca tctgaagtta atcaaagagt tttttcactt      780

gatgaagttt ttgagatagc aaactttaat aattatctaa atcaaagtgg tattactaaa      840

tttaatacta ttattggtgg taaatttgta aatggtgaaa atacaaagag aaaaggtata      900

aatgaatata taaatctata ctcacagcaa ataaatgata aaacactcaa aaaatataaa      960

atgagtgttt tatttaagca aattttaagt gatacagaat ctaaatcttt tgtaattgat     1020

aagttagaag atgatagtga tgtagttaca acgatgcaaa gtttttatga gcaaatagca     1080

gcttttaaaa cagtagaaga aaaatctatt aaagaaacac tatctttatt atttgatgat     1140

ttaaaagctc aaaaacttga tttgagtaaa atttatttta aaaatgataa atctcttact     1200

gatctatcac aacaagtttt tgatgattat agtgttattg gtacagcggt actagaatat     1260

ataactcaac aaatagcacc taaaaatctt gataacccta gtaagaaaga gcaagaatta     1320

atagccaaaa aaactgaaaa agcaaaatac ttatctctag aaactataaa gcttgcctta     1380

gaagaattta ataagcatag agatatagat aaacagtgta ggtttgaaga aatacttgca     1440

aactttgcgg ctattccgat gatatttgat gaaatagctc aaaacaaaga caatttggca     1500

cagatatcta tcaaatatca aaatcaaggt aaaaaagacc tacttcaagc tagtgcggaa     1560

gatgatgtta aagctatcaa ggatctttta gatcaaacta ataatctctt acataaacta     1620

aaaatatttc atattagtca gtcagaagat aaggcaaata ttttagacaa ggatgagcat     1680

ttttatctag tatttgagga gtgctacttt gagctagcga atatagtgcc tctttataac     1740

aaaattagaa actatataac tcaaaagcca tatagtgatg agaaatttaa gctcaatttt     1800

gagaactcga ctttggctaa tggttgggat aaaaataaag agcctgacaa tacggcaatt     1860

ttatttatca aagatgataa atattatctg ggtgtgatga ataagaaaaa taacaaaata     1920

tttgatgata aagctatcaa agaaaataaa ggcgagggtt ataaaaaaat tgtttataaa     1980

cttttacctg gcgcaaataa aatgttacct aaggttttct tttctgctaa atctataaaa     2040

ttttataatc ctagtgaaga tatacttaga ataagaaatc attccacaca tacaaaaaat     2100

ggtagtcctc aaaaaggata tgaaaaattt gagtttaata ttgaagattg ccgaaaattt     2160

atagattttt ataaacagtc tataagtaag catccggagt ggaaagattt tggatttaga     2220

ttttctgata ctcaaagata taattctata gatgaatttt atagagaagt tgaaaatcaa     2280

ggctacaaac taacttttga aaatatatca gagagctata ttgatagcgt agttaatcag     2340

ggtaaattgt acctattcca aatctataat aaagattttt cagcttatag caaagggcga     2400

ccaaatctac atactttata ttggaaagcg ctgtttgatg agagaaatct tcaagatgtg     2460

gtttataagc taaatggtga ggcagagctt ttttatcgta aacaatcaat acctaaaaaa     2520

atcactcacc cagctaaaga ggcaatagct aataaaaaca aagataatcc taaaaaagag     2580

agtgtttttg aatatgattt aatcaaagat aaacgcttta ctgaagataa gtttttcttt     2640

cactgtccta ttacaatcaa ttttaaatct agtggagcta ataagtttaa tgatgaaatc     2700

aatttattgc taaaagaaaa agcaaatgat gttcatatat taagtataga tagaggtgaa     2760

agacatttag cttactatac tttggtagat ggtaaaggca atatcatcaa acaagatact     2820

ttcaacatca ttggtaatga tagaatgaaa acaaactacc atgataagct tgctgcaata     2880

gagaaagata gggattcagc taggaaagac tggaaaaaga taaataacat caaagagatg     2940

aaagagggct atctatctca ggtagttcat gaaatagcta agctagttat agagtataat     3000

gctattgtgg tttttgagga tttaaatttt ggatttaaaa gagggcgttt caaggtagag     3060

aagcaggtct atcaaaagtt agaaaaaatg ctaattgaga aactaaacta tctagttttc     3120

aaagataatg agtttgataa aactggggga gtgcttagag cttatcagct aacagcacct     3180

tttgagactt ttaaaaagat gggtaaacaa acaggtatta tctactatgt accagctggt     3240

tttacttcaa aaatttgtcc tgtaactggt tttgtaaatc agttatatcc taagtatgaa     3300

agtgtcagca aatctcaaga gttctttagt aagtttgaca agatttgtta taaccttgat     3360

aagggctatt ttgagtttag ttttgattat aaaaactttg gtgacaaggc tgccaaaggc     3420

aagtggacta tagctagctt tgggagtaga ttgattaact ttagaaattc agataaaaat     3480

cataattggg atactcgaga agtttatcca actaaagagt tggagaaatt gctaaaagat     3540

tattctatcg aatatgggca tggcgaatgt atcaaagcag ctatttgcgg tgagagcgac     3600

aaaaagtttt ttgctaagct aactagtgtc ctaaatacta tcttacaaat gcgtaactca     3660

aaaacaggta ctgagttaga ttatctaatt tcaccagtag cagatgtaaa tggcaatttc     3720

tttgattcgc gacaggcgcc aaaaaatatg cctcaagatg ctgatgccaa tggtgcttat     3780

catattgggc taaaaggtct gatgctacta ggtaggatca aaaataatca agagggcaaa     3840

aaactcaatt tggttatcaa aaatgaagag tattttgagt tcgtgcagaa taggaataac     3900

taa                                                                   3903


<210>  109
<211>  1300
<212>  PRT
<213>  Francisella novicida

<400>  109

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  110
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  110
gtcaaaagac ctttttaatt tctactcttg tagat                                  35


<210>  111
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  111
ggaatttcta ctattgtaga t                                                 21


<210>  112
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  112
ggaatttcta ctgttgtaga t                                                 21


<210>  113
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  113
ggaatttcta cttttgtaga t                                                 21


<210>  114
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  114
ggaatttcta ctagtgtaga t                                                 21


<210>  115
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial DNA Primer

<400>  115
ggaatttcta ctcttgtaga t                                                 21


