               SEQUENCE LISTING

<110> INPROTHER ApS

<120> A vaccine for use in the prophylaxis and/or treatment of a disease

<130> INPAP.0002 WO

<150> DK 2017 70659
<151> 2017-09-01

<160> 55

<170> BiSSAP 1.3.6

<210> 1
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 1
Leu Ala Asn Gln Ile Asn Asp Leu Arg Gln Thr Val Ile Trp 
1               5                   10                  

<210> 2
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 2
Leu Ala Ser Gln Ile Asn Asp Leu Arg Gln Thr Val Ile Trp 
1               5                   10                  

<210> 3
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 3
Leu Gln Asn Arg Arg Gly Leu Asp Leu Leu Thr Ala Glu Lys Gly Gly 
1               5                   10                  15      
Leu 
    

<210> 4
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 4
Leu Gln Asn Arg Arg Ala Leu Asp Leu Leu Thr Ala Glu Arg Gly Gly 
1               5                   10                  15      
Thr 
    

<210> 5
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 5
Leu Gln Asn Arg Arg Gly Leu Asp Met Leu Thr Ala Ala Gln Gly Gly 
1               5                   10                  15      
Ile 
    

<210> 6
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 6
Tyr Gln Asn Arg Leu Ala Leu Asp Tyr Leu Leu Ala Ala Glu Gly Gly 
1               5                   10                  15      
Val 
    

<210> 7
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 7
Leu Gln Asn Arg Arg Gly Leu Asp Leu Leu Phe Leu Lys Glu Gly Gly 
1               5                   10                  15      
Leu 
    

<210> 8
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 8
Leu Gln Asn Arg Arg Gly Leu Asp Leu Leu Phe Leu Lys Arg Gly Gly 
1               5                   10                  15      
Leu 
    

<210> 9
<211> 699
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 9
Met Asn Pro Ser Glu Met Gln Arg Lys Ala Pro Pro Arg Arg Arg Arg 
1               5                   10                  15      
His Arg Asn Arg Ala Pro Leu Thr His Lys Met Asn Lys Met Val Thr 
            20                  25                  30          
Ser Glu Glu Gln Met Lys Leu Pro Ser Thr Lys Lys Ala Glu Pro Pro 
        35                  40                  45              
Thr Trp Ala Gln Leu Lys Lys Leu Thr Gln Leu Ala Thr Lys Tyr Leu 
    50                  55                  60                  
Glu Asn Thr Lys Val Thr Gln Thr Pro Glu Ser Met Leu Leu Ala Ala 
65                  70                  75                  80  
Leu Met Ile Val Ser Met Val Val Ser Leu Pro Met Pro Ala Gly Ala 
                85                  90                  95      
Ala Ala Ala Asn Tyr Thr Tyr Trp Ala Tyr Val Pro Phe Pro Pro Leu 
            100                 105                 110         
Ile Arg Ala Val Thr Trp Met Asp Asn Pro Thr Glu Val Tyr Val Asn 
        115                 120                 125             
Asp Ser Val Trp Val Pro Gly Pro Ile Asp Asp Arg Cys Pro Ala Lys 
    130                 135                 140                 
Pro Glu Glu Glu Gly Met Met Ile Asn Ile Ser Ile Gly Tyr His Tyr 
145                 150                 155                 160 
Pro Pro Ile Cys Leu Gly Arg Ala Pro Gly Cys Leu Met Pro Ala Val 
                165                 170                 175     
Gln Asn Trp Leu Val Glu Val Pro Thr Val Ser Pro Ile Cys Arg Phe 
            180                 185                 190         
Thr Tyr His Met Val Ser Gly Met Ser Leu Arg Pro Arg Val Asn Tyr 
        195                 200                 205             
Leu Gln Asp Phe Ser Tyr Gln Arg Ser Leu Lys Phe Arg Pro Lys Gly 
    210                 215                 220                 
Lys Pro Cys Pro Lys Glu Ile Pro Lys Glu Ser Lys Asn Thr Glu Val 
225                 230                 235                 240 
Leu Val Trp Glu Glu Cys Val Ala Asn Ser Ala Val Ile Leu Gln Asn 
                245                 250                 255     
Asn Glu Phe Gly Thr Ile Ile Asp Trp Ala Pro Arg Gly Gln Phe Tyr 
            260                 265                 270         
His Asn Cys Ser Gly Gln Thr Gln Ser Cys Pro Ser Ala Gln Val Ser 
        275                 280                 285             
Pro Ala Val Asp Ser Asp Leu Thr Glu Ser Leu Asp Lys His Lys His 
    290                 295                 300                 
Lys Lys Leu Gln Ser Phe Tyr Pro Trp Glu Trp Gly Glu Lys Gly Ile 
305                 310                 315                 320 
Ser Thr Pro Arg Pro Lys Ile Val Ser Pro Val Ser Gly Pro Glu His 
                325                 330                 335     
Pro Glu Leu Trp Arg Leu Thr Val Ala Ser His His Ile Arg Ile Trp 
            340                 345                 350         
Ser Gly Asn Gln Thr Leu Glu Thr Arg Asp Arg Lys Pro Phe Tyr Thr 
        355                 360                 365             
Ile Asp Leu Asn Ser Ser Leu Thr Val Pro Leu Gln Ser Cys Val Lys 
    370                 375                 380                 
Pro Pro Tyr Met Leu Val Val Gly Asn Ile Val Ile Lys Pro Asp Ser 
385                 390                 395                 400 
Gln Thr Ile Thr Cys Glu Asn Cys Arg Leu Leu Thr Cys Ile Asp Ser 
                405                 410                 415     
Thr Phe Asn Trp Gln His Arg Ile Leu Leu Val Arg Ala Arg Glu Gly 
            420                 425                 430         
Val Trp Ile Pro Val Ser Met Asp Arg Pro Trp Glu Ala Ser Pro Ser 
        435                 440                 445             
Val His Ile Leu Thr Glu Val Leu Lys Gly Val Leu Asn Arg Ser Lys 
    450                 455                 460                 
Arg Phe Ile Phe Thr Leu Ile Ala Val Ile Met Gly Leu Ile Ala Val 
465                 470                 475                 480 
Thr Ala Thr Ala Ala Val Ala Gly Val Ala Leu His Ser Ser Val Gln 
                485                 490                 495     
Ser Val Asn Phe Val Asn Asp Trp Gln Lys Asn Ser Thr Arg Leu Trp 
            500                 505                 510         
Asn Ser Gln Ser Ser Ile Asp Gln Lys Leu Ala Asn Gln Ile Asn Asp 
        515                 520                 525             
Leu Arg Gln Thr Val Ile Trp Met Gly Asp Arg Leu Met Ser Leu Glu 
    530                 535                 540                 
His Arg Phe Gln Leu Gln Cys Asp Trp Asn Thr Ser Asp Phe Cys Ile 
545                 550                 555                 560 
Thr Pro Gln Ile Tyr Asn Glu Ser Glu His His Trp Asp Met Val Arg 
                565                 570                 575     
Arg His Leu Gln Gly Arg Glu Asp Asn Leu Thr Leu Asp Ile Ser Lys 
            580                 585                 590         
Leu Lys Glu Gln Ile Phe Glu Ala Ser Lys Ala His Leu Asn Leu Val 
        595                 600                 605             
Pro Gly Thr Glu Ala Ile Ala Gly Val Ala Asp Gly Leu Ala Asn Leu 
    610                 615                 620                 
Asn Pro Val Thr Trp Val Lys Thr Ile Gly Ser Thr Thr Ile Ile Asn 
625                 630                 635                 640 
Leu Ile Leu Ile Leu Val Cys Leu Phe Cys Leu Leu Leu Val Cys Arg 
                645                 650                 655     
Cys Thr Gln Gln Leu Arg Arg Asp Ser Asp His Arg Glu Arg Ala Met 
            660                 665                 670         
Met Thr Met Ala Val Leu Ser Lys Arg Lys Gly Gly Asn Val Gly Lys 
        675                 680                 685             
Ser Lys Arg Asp Gln Ile Val Thr Val Ser Val 
    690                 695                 

<210> 10
<211> 666
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 10
Met Gly Gln Thr Lys Ser Lys Ile Lys Ser Lys Tyr Ala Ser Tyr Leu 
1               5                   10                  15      
Ser Phe Ile Lys Ile Leu Leu Lys Arg Gly Gly Val Lys Val Ser Thr 
            20                  25                  30          
Lys Asn Leu Ile Lys Leu Phe Gln Ile Ile Glu Gln Phe Cys Pro Trp 
        35                  40                  45              
Phe Pro Glu Gln Gly Thr Leu Asp Leu Lys Asp Trp Lys Arg Ile Gly 
    50                  55                  60                  
Lys Glu Leu Lys Gln Ala Gly Arg Lys Gly Asn Ile Ile Pro Leu Thr 
65                  70                  75                  80  
Val Trp Asn Asp Trp Ala Ile Ile Lys Ala Ala Leu Glu Pro Phe Gln 
                85                  90                  95      
Thr Glu Glu Asp Ser Val Ser Val Ser Asp Ala Pro Gly Ser Cys Ile 
            100                 105                 110         
Ile Asp Cys Asn Glu Asn Thr Arg Lys Lys Ser Gln Lys Glu Thr Glu 
        115                 120                 125             
Gly Leu His Cys Glu Tyr Val Ala Glu Pro Val Met Ala Gln Ser Thr 
    130                 135                 140                 
Gln Asn Val Asp Tyr Asn Gln Leu Gln Glu Val Ile Tyr Pro Glu Thr 
145                 150                 155                 160 
Leu Lys Leu Glu Gly Lys Gly Pro Glu Leu Val Gly Pro Ser Glu Ser 
                165                 170                 175     
Lys Pro Arg Gly Thr Ser Pro Leu Pro Ala Gly Gln Val Pro Val Thr 
            180                 185                 190         
Leu Gln Pro Gln Lys Gln Val Lys Glu Asn Lys Thr Gln Pro Pro Val 
        195                 200                 205             
Ala Tyr Gln Tyr Trp Pro Pro Ala Glu Leu Gln Tyr Arg Pro Pro Pro 
    210                 215                 220                 
Glu Ser Gln Tyr Gly Tyr Pro Gly Met Pro Pro Ala Pro Gln Gly Arg 
225                 230                 235                 240 
Ala Pro Tyr Pro Gln Pro Pro Thr Arg Arg Leu Asn Pro Thr Ala Pro 
                245                 250                 255     
Pro Ser Arg Gln Gly Ser Lys Leu His Glu Ile Ile Asp Lys Ser Arg 
            260                 265                 270         
Lys Glu Gly Asp Thr Glu Ala Trp Gln Phe Pro Val Thr Leu Glu Pro 
        275                 280                 285             
Met Pro Pro Gly Glu Gly Ala Gln Glu Gly Glu Pro Pro Thr Val Glu 
    290                 295                 300                 
Ala Arg Tyr Lys Ser Phe Ser Ile Lys Lys Leu Lys Asp Met Lys Glu 
305                 310                 315                 320 
Gly Val Lys Gln Tyr Gly Pro Asn Ser Pro Tyr Met Arg Thr Leu Leu 
                325                 330                 335     
Asp Ser Ile Ala His Gly His Arg Leu Ile Pro Tyr Asp Trp Glu Ile 
            340                 345                 350         
Leu Ala Lys Ser Ser Leu Ser Pro Ser Gln Phe Leu Gln Phe Lys Thr 
        355                 360                 365             
Trp Trp Ile Asp Gly Val Gln Glu Gln Val Arg Arg Asn Arg Ala Ala 
    370                 375                 380                 
Asn Pro Pro Val Asn Ile Asp Ala Asp Gln Leu Leu Gly Ile Gly Gln 
385                 390                 395                 400 
Asn Trp Ser Thr Ile Ser Gln Gln Ala Leu Met Gln Asn Glu Ala Ile 
                405                 410                 415     
Glu Gln Val Arg Ala Ile Cys Leu Arg Ala Trp Glu Lys Ile Gln Asp 
            420                 425                 430         
Pro Gly Ser Thr Cys Pro Ser Phe Asn Thr Val Arg Gln Gly Ser Lys 
        435                 440                 445             
Glu Pro Tyr Pro Asp Phe Val Ala Arg Leu Gln Asp Val Ala Gln Lys 
    450                 455                 460                 
Ser Ile Ala Asp Glu Lys Ala Arg Lys Val Ile Val Glu Leu Met Ala 
465                 470                 475                 480 
Tyr Glu Asn Ala Asn Pro Glu Cys Gln Ser Ala Ile Lys Pro Leu Lys 
                485                 490                 495     
Gly Lys Val Pro Ala Gly Ser Asp Val Ile Ser Glu Tyr Val Lys Ala 
            500                 505                 510         
Cys Asp Gly Ile Gly Gly Ala Met His Lys Ala Met Leu Met Ala Gln 
        515                 520                 525             
Ala Ile Thr Gly Val Val Leu Gly Gly Gln Val Arg Thr Phe Gly Arg 
    530                 535                 540                 
Lys Cys Tyr Asn Cys Gly Gln Ile Gly His Leu Lys Lys Asn Cys Pro 
545                 550                 555                 560 
Val Leu Asn Lys Gln Asn Ile Thr Ile Gln Ala Thr Thr Thr Gly Arg 
                565                 570                 575     
Glu Pro Pro Asp Leu Cys Pro Arg Cys Lys Lys Gly Lys His Trp Ala 
            580                 585                 590         
Ser Gln Cys Arg Ser Lys Phe Asp Lys Asn Gly Gln Pro Leu Ser Gly 
        595                 600                 605             
Asn Glu Gln Arg Gly Gln Pro Gln Ala Pro Gln Gln Thr Gly Ala Phe 
    610                 615                 620                 
Pro Ile Gln Pro Phe Val Pro Gln Gly Phe Gln Gly Gln Gln Pro Pro 
625                 630                 635                 640 
Leu Ser Gln Val Phe Gln Gly Ile Ser Gln Leu Pro Gln Tyr Asn Asn 
                645                 650                 655     
Cys Pro Pro Pro Gln Ala Ala Val Gln Gln 
            660                 665     

<210> 11
<211> 699
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 11
Met Asn Pro Ser Glu Met Gln Arg Lys Ala Pro Pro Arg Arg Arg Arg 
1               5                   10                  15      
His Arg Asn Arg Ala Pro Leu Thr His Lys Met Asn Lys Met Val Thr 
            20                  25                  30          
Ser Glu Glu Gln Met Lys Leu Pro Ser Thr Lys Lys Ala Glu Pro Pro 
        35                  40                  45              
Thr Trp Ala Gln Leu Lys Lys Leu Thr Gln Leu Ala Thr Lys Tyr Leu 
    50                  55                  60                  
Glu Asn Thr Lys Val Thr Gln Thr Pro Glu Ser Met Leu Leu Ala Ala 
65                  70                  75                  80  
Leu Met Ile Val Ser Met Val Val Ser Leu Pro Met Pro Ala Gly Ala 
                85                  90                  95      
Ala Ala Ala Asn Tyr Thr Tyr Trp Ala Tyr Val Pro Phe Pro Pro Leu 
            100                 105                 110         
Ile Arg Ala Val Thr Trp Met Asp Asn Pro Ile Glu Val Tyr Val Asn 
        115                 120                 125             
Asp Ser Val Trp Val Pro Gly Pro Thr Asp Asp His Cys Pro Ala Lys 
    130                 135                 140                 
Pro Glu Glu Glu Gly Met Met Ile Asn Ile Ser Ile Gly Tyr Arg Tyr 
145                 150                 155                 160 
Pro Pro Ile Cys Leu Gly Arg Ala Pro Gly Cys Leu Met Pro Ala Val 
                165                 170                 175     
Gln Asn Trp Leu Val Glu Val Pro Thr Val Ser Pro Ile Ser Arg Phe 
            180                 185                 190         
Thr Tyr His Met Val Ser Gly Met Ser Leu Arg Pro Arg Val Asn Tyr 
        195                 200                 205             
Leu Gln Asp Phe Ser Tyr Gln Arg Ser Phe Lys Phe Arg Pro Lys Gly 
    210                 215                 220                 
Lys Pro Cys Pro Lys Glu Ile Pro Lys Glu Ser Lys Asn Thr Glu Val 
225                 230                 235                 240 
Leu Val Trp Glu Glu Cys Val Ala Asn Ser Ala Val Ile Leu Gln Asn 
                245                 250                 255     
Asn Glu Phe Gly Thr Ile Ile Asp Trp Ala Pro Arg Gly Gln Phe Tyr 
            260                 265                 270         
His Asn Cys Ser Gly Gln Thr Gln Ser Cys Pro Ser Ala Gln Val Ser 
        275                 280                 285             
Pro Ala Val Asp Ser Asp Leu Thr Glu Ser Leu Asp Lys His Lys His 
    290                 295                 300                 
Lys Lys Leu Gln Ser Phe Tyr Pro Trp Glu Trp Gly Glu Lys Gly Ile 
305                 310                 315                 320 
Ser Thr Pro Arg Pro Lys Ile Ile Ser Pro Val Ser Gly Pro Glu His 
                325                 330                 335     
Pro Glu Leu Trp Arg Leu Thr Val Ala Ser His His Ile Arg Ile Trp 
            340                 345                 350         
Ser Gly Asn Gln Thr Leu Glu Thr Arg Asp Arg Lys Pro Phe Tyr Thr 
        355                 360                 365             
Val Asp Leu Asn Ser Ser Val Thr Val Pro Leu Gln Ser Cys Ile Lys 
    370                 375                 380                 
Pro Pro Tyr Met Leu Val Val Gly Asn Ile Val Ile Lys Pro Asp Ser 
385                 390                 395                 400 
Gln Thr Ile Thr Cys Glu Asn Cys Arg Leu Leu Thr Cys Ile Asp Ser 
                405                 410                 415     
Thr Phe Asn Trp Gln His Arg Ile Leu Leu Val Arg Ala Arg Glu Gly 
            420                 425                 430         
Val Trp Ile Pro Val Ser Met Asp Arg Pro Trp Glu Thr Ser Pro Ser 
        435                 440                 445             
Ile His Thr Leu Thr Glu Val Leu Lys Gly Val Leu Asn Arg Ser Lys 
    450                 455                 460                 
Arg Phe Ile Phe Thr Leu Ile Ala Val Ile Met Gly Leu Ile Ala Val 
465                 470                 475                 480 
Thr Ala Thr Ala Ala Val Ala Gly Val Ala Leu His Ser Ser Val Gln 
                485                 490                 495     
Ser Val Asn Phe Val Asn Asp Trp Gln Lys Asn Ser Thr Arg Leu Trp 
            500                 505                 510         
Asn Ser Gln Ser Ser Ile Asp Gln Lys Leu Ala Asn Gln Ile Asn Asp 
        515                 520                 525             
Leu Arg Gln Thr Val Ile Trp Met Gly Asp Arg Leu Met Ser Leu Glu 
    530                 535                 540                 
His Arg Phe Gln Leu Gln Cys Asp Trp Asn Thr Ser Asp Phe Ser Ile 
545                 550                 555                 560 
Thr Pro Gln Ile Tyr Asn Glu Ser Glu His His Trp Asp Met Val Arg 
                565                 570                 575     
Arg His Leu Gln Gly Arg Glu Asp Asn Leu Thr Leu Asp Ile Ser Lys 
            580                 585                 590         
Leu Lys Glu Gln Ile Phe Glu Ala Ser Lys Ala His Leu Asn Leu Val 
        595                 600                 605             
Pro Gly Thr Glu Ala Ile Ala Gly Val Ala Asp Gly Leu Ala Asn Leu 
    610                 615                 620                 
Asn Pro Val Thr Trp Val Lys Thr Ile Gly Ser Thr Thr Ile Ile Asn 
625                 630                 635                 640 
Leu Ile Leu Ile Leu Val Cys Leu Phe Cys Leu Leu Leu Val Cys Arg 
                645                 650                 655     
Cys Thr Gln Gln Leu Arg Arg Asp Ser Asp His Arg Glu Arg Ala Met 
            660                 665                 670         
Met Thr Met Ala Val Leu Ser Lys Arg Lys Gly Gly Asn Val Gly Lys 
        675                 680                 685             
Ser Lys Arg Asp Gln Ile Val Thr Val Ser Val 
    690                 695                 

<210> 12
<211> 666
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 12
Met Gly Gln Thr Lys Ser Lys Ile Lys Ser Lys Tyr Ala Ser Tyr Leu 
1               5                   10                  15      
Ser Phe Ile Lys Ile Leu Leu Lys Arg Gly Gly Val Lys Val Ser Thr 
            20                  25                  30          
Lys Asn Leu Ile Lys Leu Phe Gln Ile Ile Glu Gln Phe Cys Pro Trp 
        35                  40                  45              
Phe Pro Glu Gln Gly Thr Leu Asp Leu Lys Asp Trp Lys Arg Ile Gly 
    50                  55                  60                  
Lys Glu Leu Lys Gln Ala Gly Arg Lys Gly Asn Ile Ile Pro Leu Thr 
65                  70                  75                  80  
Val Trp Asn Asp Trp Ala Ile Ile Lys Ala Ala Leu Glu Pro Phe Gln 
                85                  90                  95      
Thr Glu Glu Asp Ser Val Ser Val Ser Asp Ala Pro Gly Ser Cys Ile 
            100                 105                 110         
Ile Asp Cys Asn Glu Asn Thr Arg Lys Lys Ser Gln Lys Glu Thr Glu 
        115                 120                 125             
Ser Leu His Cys Glu Tyr Val Ala Glu Pro Val Met Ala Gln Ser Thr 
    130                 135                 140                 
Gln Asn Val Asp Tyr Asn Gln Leu Gln Glu Val Ile Tyr Pro Glu Thr 
145                 150                 155                 160 
Leu Lys Leu Glu Gly Lys Val Pro Glu Leu Val Gly Pro Ser Glu Ser 
                165                 170                 175     
Lys Pro Arg Gly Thr Ser Arg Leu Pro Ala Gly Gln Val Pro Val Thr 
            180                 185                 190         
Leu Gln Pro Gln Thr Gln Val Lys Glu Asn Lys Thr Gln Pro Pro Val 
        195                 200                 205             
Ala Tyr Gln Tyr Trp Pro Pro Ala Glu Leu Gln Tyr Arg Pro Pro Leu 
    210                 215                 220                 
Glu Ser Gln Tyr Gly Tyr Pro Gly Met Pro Pro Ala Pro Gln Gly Arg 
225                 230                 235                 240 
Ala Pro Tyr Pro Gln Pro Pro Thr Arg Arg Leu Asn Pro Thr Ala Pro 
                245                 250                 255     
Pro Ser Arg Arg Gly Ser Glu Leu His Glu Ile Ile Asp Lys Ser Arg 
            260                 265                 270         
Lys Glu Gly Asp Thr Glu Ala Trp Gln Phe Pro Val Thr Leu Glu Pro 
        275                 280                 285             
Met Pro Pro Gly Glu Gly Ala Gln Glu Gly Glu Pro Pro Thr Val Glu 
    290                 295                 300                 
Ala Arg Tyr Lys Ser Phe Ser Ile Lys Met Leu Lys Asp Met Lys Glu 
305                 310                 315                 320 
Gly Val Lys Gln Tyr Gly Pro Asn Ser Pro Tyr Met Arg Thr Leu Leu 
                325                 330                 335     
Asp Ser Ile Ala His Gly His Arg Leu Ile Pro Tyr Asp Trp Glu Ile 
            340                 345                 350         
Leu Ala Lys Ser Ser Leu Ser Pro Ser Gln Phe Leu Gln Phe Lys Thr 
        355                 360                 365             
Trp Trp Ile Asp Gly Val Gln Glu Gln Val Arg Arg Asn Arg Ala Ala 
    370                 375                 380                 
Asn Pro Pro Val Asn Ile Asp Ala Asp Gln Leu Leu Gly Ile Gly Gln 
385                 390                 395                 400 
Asn Trp Ser Thr Ile Ser Gln Gln Ala Leu Met Gln Asn Glu Ala Ile 
                405                 410                 415     
Glu Gln Val Arg Ala Ile Cys Leu Arg Ala Trp Glu Lys Ile Gln Asp 
            420                 425                 430         
Pro Gly Ser Thr Cys Pro Ser Phe Asn Thr Val Arg Gln Gly Ser Lys 
        435                 440                 445             
Glu Pro Tyr Pro Asp Phe Val Ala Arg Leu Gln Asp Val Ala Gln Lys 
    450                 455                 460                 
Ser Ile Ala Ile Glu Lys Ala Arg Lys Val Ile Val Glu Leu Met Ala 
465                 470                 475                 480 
Tyr Glu Asn Pro Asn Pro Glu Cys Gln Ser Ala Ile Lys Pro Leu Lys 
                485                 490                 495     
Gly Lys Val Pro Ala Gly Ser Asp Val Ile Ser Glu Tyr Val Lys Ala 
            500                 505                 510         
Cys Asp Gly Met Gly Gly Ala Met His Lys Ala Met Leu Met Ala Gln 
        515                 520                 525             
Ala Ile Thr Gly Val Val Leu Gly Gly Gln Val Arg Thr Phe Gly Gly 
    530                 535                 540                 
Lys Cys Tyr Asn Cys Gly Gln Ile Gly His Leu Lys Lys Asn Cys Pro 
545                 550                 555                 560 
Val Leu Asn Lys Gln Asn Ile Thr Ile Gln Ala Thr Thr Thr Gly Arg 
                565                 570                 575     
Glu Pro Pro Asp Leu Cys Pro Arg Cys Lys Lys Gly Lys His Trp Ala 
            580                 585                 590         
Ser Gln Cys Arg Ser Lys Phe Asp Lys Asn Gly Gln Pro Leu Ser Gly 
        595                 600                 605             
Asn Glu Gln Arg Gly Gln Pro Gln Ala Pro Gln Gln Thr Gly Ala Phe 
    610                 615                 620                 
Pro Ile Gln Pro Phe Val Pro His Gly Phe Gln Gly Gln Gln Pro Pro 
625                 630                 635                 640 
Leu Ser Gln Val Phe Gln Gly Ile Ser Gln Leu Pro Gln Tyr Asn Asn 
                645                 650                 655     
Cys Pro Pro Pro Gln Ala Ala Val Gln Gln 
            660                 665     

<210> 13
<211> 699
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 13
Met Asn Pro Ser Glu Met Gln Arg Lys Ala Pro Pro Arg Arg Arg Arg 
1               5                   10                  15      
His Arg Asn Arg Ala Pro Leu Thr His Lys Met Asn Lys Met Val Thr 
            20                  25                  30          
Ser Glu Glu Gln Met Lys Leu Pro Ser Thr Lys Lys Ala Glu Pro Pro 
        35                  40                  45              
Thr Trp Ala Gln Leu Lys Lys Leu Thr Gln Leu Ala Thr Lys Tyr Leu 
    50                  55                  60                  
Glu Asn Thr Lys Val Thr Gln Thr Pro Glu Ser Met Leu Leu Ala Ala 
65                  70                  75                  80  
Leu Met Ile Val Ser Met Val Val Ser Leu Pro Met Pro Ala Gly Ala 
                85                  90                  95      
Ala Val Ala Asn Tyr Thr Asn Trp Ala Tyr Val Pro Phe Pro Pro Leu 
            100                 105                 110         
Ile Arg Ala Val Thr Trp Met Asp Asn Pro Ile Glu Val Tyr Val Asn 
        115                 120                 125             
Asp Ser Val Trp Val Pro Gly Pro Ile Asp Asp Arg Cys Pro Ala Lys 
    130                 135                 140                 
Pro Glu Glu Glu Gly Met Met Ile Asn Ile Ser Ile Gly Tyr Arg Tyr 
145                 150                 155                 160 
Pro Pro Ile Cys Leu Gly Arg Ala Pro Gly Cys Leu Met Pro Ala Val 
                165                 170                 175     
Gln Asn Trp Leu Val Glu Val Pro Thr Val Ser Pro Ile Ser Arg Phe 
            180                 185                 190         
Thr Tyr His Met Val Ser Gly Met Ser Leu Arg Pro Arg Val Asn Tyr 
        195                 200                 205             
Leu Gln Asp Phe Ser Tyr Gln Arg Ser Leu Lys Phe Arg Pro Lys Gly 
    210                 215                 220                 
Lys Pro Cys Pro Lys Glu Ile Pro Lys Glu Ser Lys Asn Thr Glu Val 
225                 230                 235                 240 
Leu Val Trp Glu Glu Cys Val Ala Asn Ser Ala Val Ile Leu Gln Asn 
                245                 250                 255     
Asn Glu Phe Gly Thr Ile Ile Asp Trp Ala Pro Arg Gly Gln Phe Tyr 
            260                 265                 270         
His Asn Cys Ser Gly Gln Thr Gln Ser Cys Pro Ser Ala Gln Val Ser 
        275                 280                 285             
Pro Ala Val Asp Ser Asp Leu Thr Glu Ser Leu Asp Lys His Lys His 
    290                 295                 300                 
Lys Lys Leu Gln Ser Phe Tyr Pro Trp Glu Trp Gly Glu Lys Arg Ile 
305                 310                 315                 320 
Ser Thr Pro Arg Pro Lys Ile Val Ser Pro Val Ser Gly Pro Glu His 
                325                 330                 335     
Pro Glu Leu Trp Arg Leu Thr Val Ala Ser His His Ile Arg Ile Trp 
            340                 345                 350         
Ser Gly Asn Gln Thr Leu Glu Thr Arg Asp Arg Lys Pro Phe Tyr Thr 
        355                 360                 365             
Val Asp Leu Asn Ser Ser Leu Thr Leu Pro Leu Gln Ser Cys Val Lys 
    370                 375                 380                 
Pro Pro Tyr Met Leu Val Val Gly Asn Ile Val Ile Lys Pro Asp Ser 
385                 390                 395                 400 
Gln Thr Ile Thr Cys Glu Asn Cys Arg Leu Leu Thr Cys Ile Asp Ser 
                405                 410                 415     
Thr Phe Asn Trp Gln His Arg Ile Leu Leu Val Arg Ala Arg Glu Gly 
            420                 425                 430         
Val Trp Ile Pro Val Ser Met Asp Arg Pro Trp Glu Ala Ser Pro Ser 
        435                 440                 445             
Val His Ile Leu Thr Glu Val Leu Lys Gly Val Leu Asn Arg Ser Lys 
    450                 455                 460                 
Arg Phe Ile Phe Thr Leu Ile Ala Val Ile Met Gly Leu Ile Ala Val 
465                 470                 475                 480 
Thr Ala Thr Ala Ala Val Ala Gly Val Ala Leu His Ser Ser Val Gln 
                485                 490                 495     
Ser Val Asn Phe Val Asn Asp Gly Gln Lys Asn Ser Thr Arg Leu Trp 
            500                 505                 510         
Asn Ser Gln Ser Ser Ile Asp Gln Lys Leu Ala Asn Gln Ile Asn Asp 
        515                 520                 525             
Leu Arg Gln Thr Val Ile Trp Met Gly Asp Arg Leu Met Ser Leu Glu 
    530                 535                 540                 
His Arg Phe Gln Leu Gln Cys Asp Trp Asn Thr Ser Asp Phe Cys Ile 
545                 550                 555                 560 
Thr Pro Gln Ile Tyr Asn Asp Ser Glu His His Trp Asp Met Val Arg 
                565                 570                 575     
Arg His Leu Gln Gly Arg Glu Asp Asn Leu Thr Leu Asp Ile Ser Lys 
            580                 585                 590         
Leu Lys Glu Gln Ile Phe Glu Ala Ser Lys Ala His Leu Asn Leu Val 
        595                 600                 605             
Pro Gly Thr Glu Ala Ile Ala Gly Val Ala Asp Gly Leu Ala Asn Leu 
    610                 615                 620                 
Asn Pro Val Thr Trp Val Lys Thr Ile Gly Ser Thr Thr Ile Ile Asn 
625                 630                 635                 640 
Leu Ile Leu Ile Leu Val Cys Leu Phe Cys Leu Leu Leu Val Cys Arg 
                645                 650                 655     
Cys Thr Gln Gln Leu Arg Arg Asp Ser Asp His Arg Glu Arg Ala Met 
            660                 665                 670         
Met Thr Met Ala Val Leu Ser Lys Arg Lys Gly Gly Asn Val Gly Lys 
        675                 680                 685             
Ser Lys Arg Asp Gln Ile Val Thr Val Ser Val 
    690                 695                 

<210> 14
<211> 647
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 14
Met Gly Gln Thr Lys Ser Lys Ile Lys Ser Lys Tyr Ala Ser Tyr Leu 
1               5                   10                  15      
Ser Phe Ile Lys Ile Leu Leu Lys Arg Gly Gly Val Lys Val Ser Thr 
            20                  25                  30          
Lys Asn Leu Ile Lys Leu Phe Gln Ile Ile Glu Gln Phe Cys Pro Trp 
        35                  40                  45              
Phe Pro Glu Gln Gly Thr Leu Asp Leu Lys Asp Trp Lys Arg Ile Gly 
    50                  55                  60                  
Lys Glu Leu Lys Gln Ala Gly Arg Lys Gly Asn Ile Ile Pro Leu Thr 
65                  70                  75                  80  
Val Trp Asn Asp Trp Ala Ile Ile Lys Ala Ala Leu Glu Pro Phe Gln 
                85                  90                  95      
Thr Glu Glu Asp Ser Ile Ser Val Ser Asp Ala Pro Gly Ser Cys Leu 
            100                 105                 110         
Ile Asp Cys Asn Glu Asn Thr Arg Lys Lys Ser Gln Lys Glu Thr Glu 
        115                 120                 125             
Ser Leu His Cys Glu Tyr Val Ala Glu Pro Val Met Ala Gln Ser Thr 
    130                 135                 140                 
Gln Asn Val Asp Tyr Asn Gln Leu Gln Glu Val Ile Tyr Pro Glu Thr 
145                 150                 155                 160 
Leu Lys Leu Glu Gly Lys Gly Pro Glu Leu Val Gly Pro Ser Glu Ser 
                165                 170                 175     
Lys Pro Arg Gly Thr Ser Pro Leu Pro Ala Gly Gln Val Pro Val Thr 
            180                 185                 190         
Leu Gln Pro Gln Lys Gln Val Lys Glu Asn Lys Thr Gln Pro Pro Val 
        195                 200                 205             
Ala Tyr Gln Tyr Trp Pro Pro Ala Glu Leu Gln Tyr Arg Pro Pro Pro 
    210                 215                 220                 
Glu Ser Gln Tyr Gly Tyr Pro Gly Met Pro Pro Ala Pro Gln Gly Arg 
225                 230                 235                 240 
Glu Pro Tyr Pro Gln Pro Pro Thr Arg Arg Leu Asn Pro Thr Ala Pro 
                245                 250                 255     
Pro Ser Arg Gln Gly Ser Glu Leu His Glu Ile Ile Asp Lys Ser Arg 
            260                 265                 270         
Lys Glu Gly Asp Thr Glu Ala Trp Gln Phe Pro Val Thr Leu Glu Pro 
        275                 280                 285             
Met Pro Pro Gly Glu Gly Ala Gln Glu Gly Glu Pro Pro Thr Val Glu 
    290                 295                 300                 
Ala Arg Tyr Lys Ser Phe Ser Ile Lys Met Leu Lys Asp Met Lys Glu 
305                 310                 315                 320 
Gly Val Lys Gln Tyr Gly Pro Asn Ser Pro Tyr Met Arg Thr Leu Leu 
                325                 330                 335     
Asp Ser Ile Ala His Gly His Arg Leu Ile Pro Tyr Asp Trp Glu Ile 
            340                 345                 350         
Leu Ala Lys Ser Ser Leu Ser Pro Ser Gln Phe Leu Gln Phe Lys Thr 
        355                 360                 365             
Trp Trp Ile Asp Gly Val Gln Glu Gln Val Arg Arg Asn Arg Ala Ala 
    370                 375                 380                 
Asn Pro Pro Val Asn Ile Asp Ala Asp Gln Leu Leu Gly Ile Gly Gln 
385                 390                 395                 400 
Asn Trp Ser Thr Ile Ser Gln Gln Ala Leu Met Gln Asn Glu Ala Ile 
                405                 410                 415     
Glu Gln Val Arg Ala Ile Cys Leu Arg Ala Trp Glu Lys Ile Gln Asp 
            420                 425                 430         
Pro Gly Ser Thr Cys Pro Ser Phe Asn Thr Val Arg Gln Gly Ser Lys 
        435                 440                 445             
Glu Pro Tyr Pro Asp Phe Val Ala Arg Leu Gln Asp Val Ala Gln Lys 
    450                 455                 460                 
Ser Ile Ala Asp Glu Lys Ala Arg Lys Val Ile Val Glu Leu Met Ala 
465                 470                 475                 480 
Tyr Glu Asn Ala Asn Pro Glu Cys Gln Ser Ala Ile Lys Pro Leu Lys 
                485                 490                 495     
Gly Lys Val Pro Ala Gly Ser Asp Val Ile Ser Glu Tyr Val Lys Ala 
            500                 505                 510         
Cys Asp Gly Ile Gly Gly Ala Met His Lys Ala Met Leu Met Ala Gln 
        515                 520                 525             
Ala Ile Thr Gly Val Val Leu Gly Gly Gln Val Arg Thr Phe Gly Gly 
    530                 535                 540                 
Lys Cys Tyr Asn Cys Gly Gln Ile Gly His Leu Lys Lys Asn Cys Pro 
545                 550                 555                 560 
Val Leu Asn Lys Gln Asn Ile Thr Ile Gln Ala Thr Thr Thr Gly Arg 
                565                 570                 575     
Glu Pro Pro Asp Leu Cys Pro Arg Cys Lys Lys Gly Lys His Trp Ala 
            580                 585                 590         
Ser Gln Cys Arg Ser Lys Phe Asp Lys Asn Gly Gln Pro Leu Ser Gly 
        595                 600                 605             
Asn Glu Gln Arg Gly Gln Pro Gln Ala Pro Gln Gln Thr Gly Ala Phe 
    610                 615                 620                 
Pro Ile Gln Pro Phe Val Pro Gln Gly Phe Gln Asp Asn Asn Pro His 
625                 630                 635                 640 
Cys Pro Lys Cys Phe Arg Glu 
                645         

<210> 15
<211> 698
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 15
Met Asn Pro Ser Glu Met Gln Arg Lys Ala Pro Pro Arg Arg Arg Arg 
1               5                   10                  15      
His Arg Asn Arg Ala Pro Leu Thr His Lys Met Asn Lys Met Val Thr 
            20                  25                  30          
Ser Glu Glu Gln Met Lys Leu Pro Ser Thr Lys Lys Ala Glu Pro Pro 
        35                  40                  45              
Thr Trp Ala Gln Leu Lys Lys Leu Thr Gln Leu Ala Thr Lys Tyr Leu 
    50                  55                  60                  
Glu Asn Thr Lys Val Thr Gln Thr Pro Glu Ser Met Leu Leu Ala Ala 
65                  70                  75                  80  
Leu Met Ile Val Ser Met Val Val Ser Leu Pro Met Pro Ala Gly Ala 
                85                  90                  95      
Ala Ala Ala Asn Tyr Thr Asn Trp Ala Tyr Val Pro Phe Pro Pro Leu 
            100                 105                 110         
Ile Arg Ala Val Thr Trp Met Asp Asn Pro Ile Glu Val Tyr Val Asn 
        115                 120                 125             
Asp Ser Val Trp Val Pro Gly Pro Ile Asp Asp Arg Cys Pro Ala Lys 
    130                 135                 140                 
Pro Glu Glu Glu Gly Met Met Ile Asn Ile Ser Ile Gly Tyr Arg Tyr 
145                 150                 155                 160 
Pro Ile Cys Leu Gly Arg Ala Pro Gly Cys Leu Met Pro Ala Val Gln 
                165                 170                 175     
Asn Trp Leu Val Glu Val Pro Ile Val Ser Pro Ile Cys Arg Phe Thr 
            180                 185                 190         
Tyr His Met Val Ser Gly Met Ser Leu Arg Pro Arg Val Asn Tyr Leu 
        195                 200                 205             
Gln Asp Phe Ser Tyr Gln Arg Ser Leu Lys Phe Arg Pro Lys Gly Lys 
    210                 215                 220                 
Pro Cys Pro Lys Glu Ile Pro Lys Glu Ser Lys Asn Thr Glu Val Leu 
225                 230                 235                 240 
Val Trp Glu Glu Cys Val Ala Asn Ser Ala Val Ile Leu Gln Asn Asn 
                245                 250                 255     
Glu Phe Gly Thr Ile Ile Asp Trp Thr Pro Gln Gly Gln Phe Tyr His 
            260                 265                 270         
Asn Cys Ser Gly Gln Thr Gln Ser Cys Pro Ser Ala Gln Val Ser Pro 
        275                 280                 285             
Ala Val Asp Ser Asp Leu Thr Glu Ser Leu Asp Lys His Lys His Lys 
    290                 295                 300                 
Lys Leu Gln Ser Phe Tyr Pro Trp Glu Trp Gly Glu Lys Gly Ile Ser 
305                 310                 315                 320 
Thr Pro Arg Pro Lys Ile Ile Ser Pro Val Ser Gly Pro Glu His Pro 
                325                 330                 335     
Glu Leu Trp Arg Leu Thr Val Ala Ser His His Ile Arg Ile Trp Ser 
            340                 345                 350         
Gly Asn Gln Thr Leu Glu Thr Arg Asp Arg Lys Pro Phe Tyr Thr Val 
        355                 360                 365             
Asp Leu Asn Ser Ser Leu Thr Leu Pro Leu Gln Ser Cys Val Lys Pro 
    370                 375                 380                 
Pro Tyr Met Leu Val Val Gly Asn Ile Val Ile Lys Pro Asp Ser Gln 
385                 390                 395                 400 
Thr Ile Thr Cys Glu Asn Cys Arg Leu Leu Thr Cys Ile Asp Ser Thr 
                405                 410                 415     
Phe Asn Trp Gln His Arg Ile Leu Leu Val Arg Ala Arg Glu Gly Val 
            420                 425                 430         
Trp Ile Pro Val Ser Met Asp Arg Pro Trp Glu Ala Ser Pro Ser Ile 
        435                 440                 445             
His Ile Leu Thr Glu Val Leu Lys Gly Val Leu Asn Arg Ser Lys Arg 
    450                 455                 460                 
Phe Ile Phe Thr Leu Ile Ala Val Ile Met Gly Leu Ile Ala Val Thr 
465                 470                 475                 480 
Ala Thr Ala Ala Val Ala Gly Val Ala Leu His Ser Ser Val Gln Ser 
                485                 490                 495     
Val Asn Phe Val Asn Asp Gly Gln Lys Asn Ser Thr Arg Leu Trp Asn 
            500                 505                 510         
Ser Gln Ser Ser Ile Asp Gln Lys Leu Ala Asn Gln Ile Asn Asp Leu 
        515                 520                 525             
Arg Gln Thr Val Ile Trp Met Gly Asp Arg Leu Met Ser Leu Glu His 
    530                 535                 540                 
Arg Phe Gln Leu Gln Cys Asp Trp Asn Thr Ser Asp Phe Cys Ile Thr 
545                 550                 555                 560 
Pro Gln Ile Tyr Asn Glu Ser Glu His His Trp Asp Met Val Arg Arg 
                565                 570                 575     
His Leu Gln Gly Arg Glu Asp Asn Leu Thr Leu Asp Ile Ser Lys Leu 
            580                 585                 590         
Lys Glu Gln Ile Phe Glu Ala Ser Lys Ala His Leu Asn Leu Val Pro 
        595                 600                 605             
Gly Thr Glu Ala Ile Ala Gly Val Ala Asp Gly Leu Ala Asn Leu Asn 
    610                 615                 620                 
Pro Val Thr Trp Val Lys Thr Ile Gly Ser Thr Thr Ile Ile Asn Leu 
625                 630                 635                 640 
Ile Leu Ile Leu Val Cys Leu Phe Cys Leu Leu Leu Val Cys Arg Cys 
                645                 650                 655     
Thr Gln Gln Leu Arg Arg Asp Ser Asp His Arg Glu Arg Ala Met Met 
            660                 665                 670         
Thr Met Ala Val Leu Ser Lys Arg Lys Gly Gly Asn Val Gly Lys Ser 
        675                 680                 685             
Lys Arg Asp Gln Ile Val Thr Val Ser Val 
    690                 695             

<210> 16
<211> 666
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 16
Met Gly Gln Thr Lys Ser Lys Ile Lys Ser Lys Tyr Ala Ser Tyr Leu 
1               5                   10                  15      
Ser Phe Ile Lys Ile Leu Leu Lys Arg Gly Gly Val Lys Val Ser Thr 
            20                  25                  30          
Lys Asn Leu Ile Lys Leu Phe Gln Ile Ile Glu Gln Phe Cys Pro Trp 
        35                  40                  45              
Phe Pro Glu Gln Gly Thr Leu Asp Leu Lys Asp Trp Lys Arg Ile Gly 
    50                  55                  60                  
Lys Glu Leu Lys Gln Ala Gly Arg Lys Gly Asn Ile Ile Pro Leu Thr 
65                  70                  75                  80  
Val Trp Asn Asp Trp Ala Ile Ile Lys Ala Ala Leu Glu Pro Phe Gln 
                85                  90                  95      
Thr Glu Glu Asp Ser Ile Ser Val Ser Asp Ala Pro Gly Ser Gly Ile 
            100                 105                 110         
Ile Asp Cys Asn Glu Lys Thr Arg Lys Lys Ser Gln Lys Glu Thr Glu 
        115                 120                 125             
Ser Leu His Cys Glu Tyr Val Ala Glu Pro Val Met Ala Gln Ser Thr 
    130                 135                 140                 
Gln Asn Val Asp Tyr Asn Gln Leu Gln Glu Val Ile Tyr Pro Glu Thr 
145                 150                 155                 160 
Leu Lys Leu Glu Gly Lys Gly Pro Glu Leu Val Gly Pro Ser Glu Ser 
                165                 170                 175     
Lys Pro Arg Gly Thr Ser Pro Leu Pro Ala Gly Gln Val Pro Val Thr 
            180                 185                 190         
Leu Gln Pro Gln Lys Gln Val Lys Glu Asn Lys Thr Gln Pro Pro Val 
        195                 200                 205             
Ala Tyr Gln Tyr Trp Pro Pro Ala Glu Leu Gln Tyr Arg Pro Pro Pro 
    210                 215                 220                 
Glu Ser Gln Tyr Gly Tyr Pro Gly Met Pro Pro Ala Pro Gln Gly Arg 
225                 230                 235                 240 
Ala Pro Tyr Pro Gln Pro Pro Thr Arg Arg Leu Asn Pro Thr Ala Pro 
                245                 250                 255     
Pro Ser Arg Gln Gly Ser Glu Leu His Glu Ile Ile Asp Lys Ser Arg 
            260                 265                 270         
Lys Glu Gly Asp Thr Glu Ala Trp Gln Phe Pro Val Thr Leu Glu Pro 
        275                 280                 285             
Met Pro Pro Gly Glu Gly Ala Gln Glu Gly Glu Pro Pro Thr Val Glu 
    290                 295                 300                 
Ala Arg Tyr Lys Ser Phe Ser Ile Lys Ile Leu Lys Asp Met Lys Glu 
305                 310                 315                 320 
Gly Val Lys Gln Tyr Gly Pro Asn Ser Pro Tyr Met Arg Thr Leu Leu 
                325                 330                 335     
Asp Ser Ile Ala His Gly His Arg Leu Ile Pro Tyr Asp Trp Glu Ile 
            340                 345                 350         
Leu Ala Lys Ser Ser Leu Ser Pro Ser Gln Phe Leu Gln Phe Lys Thr 
        355                 360                 365             
Trp Trp Ile Asp Gly Val Gln Glu Gln Val Arg Arg Asn Arg Ala Ala 
    370                 375                 380                 
Asn Pro Pro Val Asn Ile Asp Ala Asp Gln Leu Leu Gly Ile Gly Gln 
385                 390                 395                 400 
Asn Trp Ser Thr Ile Ser Gln Gln Ala Leu Met Gln Asn Glu Ala Ile 
                405                 410                 415     
Glu Gln Val Arg Ala Ile Cys Leu Arg Ala Trp Glu Lys Ile Gln Asp 
            420                 425                 430         
Pro Gly Ser Thr Cys Pro Ser Phe Asn Thr Val Arg Gln Gly Ser Lys 
        435                 440                 445             
Glu Pro Tyr Pro Asp Phe Val Ala Arg Leu Gln Asp Val Ala Gln Lys 
    450                 455                 460                 
Ser Ile Ala Asp Glu Lys Ala Arg Lys Val Ile Val Glu Leu Met Ala 
465                 470                 475                 480 
Tyr Glu Asn Ala Asn Pro Glu Cys Gln Ser Ala Ile Lys Pro Leu Lys 
                485                 490                 495     
Gly Lys Val Pro Ala Gly Ser Asp Val Ile Ser Glu Tyr Val Lys Ala 
            500                 505                 510         
Cys Asp Gly Ile Gly Gly Ala Met His Lys Ala Met Leu Met Ala Gln 
        515                 520                 525             
Ala Ile Thr Gly Val Val Leu Gly Gly Gln Val Arg Thr Phe Gly Gly 
    530                 535                 540                 
Lys Cys Tyr Asn Cys Gly Gln Ile Gly His Leu Lys Lys Asn Cys Pro 
545                 550                 555                 560 
Val Leu Asn Lys Gln Asn Ile Thr Ile Gln Ala Thr Thr Thr Gly Arg 
                565                 570                 575     
Glu Pro Pro Asp Leu Cys Pro Arg Cys Lys Lys Gly Lys His Trp Ala 
            580                 585                 590         
Ser Gln Cys Arg Ser Lys Phe Asp Lys Asn Gly Gln Pro Leu Ser Gly 
        595                 600                 605             
Asn Glu Gln Arg Gly Gln Pro Gln Ala Pro Gln Gln Thr Gly Ala Phe 
    610                 615                 620                 
Pro Ile Gln Pro Phe Val Pro Gln Gly Phe Gln Gly Gln Gln Pro Pro 
625                 630                 635                 640 
Leu Ser Gln Val Phe Gln Gly Ile Ser Gln Leu Pro Gln Tyr Asn Asn 
                645                 650                 655     
Cys Pro Pro Pro Gln Val Ala Val Gln Gln 
            660                 665     

<210> 17
<211> 699
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 17
Met Asn Pro Ser Glu Met Gln Arg Lys Ala Pro Pro Arg Arg Arg Arg 
1               5                   10                  15      
His Arg Asn Arg Ala Pro Leu Thr His Lys Met Asn Lys Met Val Thr 
            20                  25                  30          
Ser Glu Glu Gln Met Lys Leu Pro Ser Thr Lys Lys Ala Glu Pro Pro 
        35                  40                  45              
Thr Trp Ala Gln Leu Lys Lys Leu Thr Gln Leu Ala Thr Lys Tyr Leu 
    50                  55                  60                  
Glu Asn Thr Lys Val Thr Gln Thr Pro Glu Ser Met Leu Leu Ala Ala 
65                  70                  75                  80  
Leu Met Ile Val Ser Met Val Val Ser Leu Pro Met Pro Ala Gly Ala 
                85                  90                  95      
Ala Ala Ala Asn Tyr Thr Tyr Trp Ala Tyr Val Pro Phe Pro Pro Leu 
            100                 105                 110         
Ile Arg Ala Val Thr Trp Met Asp Asn Pro Ile Glu Ile Tyr Val Asn 
        115                 120                 125             
Asp Ser Val Trp Val Pro Gly Pro Thr Asp Asp Cys Cys Pro Ala Lys 
    130                 135                 140                 
Pro Glu Glu Glu Gly Met Met Ile Asn Ile Ser Ile Gly Tyr Arg Tyr 
145                 150                 155                 160 
Pro Pro Ile Cys Leu Gly Arg Ala Pro Gly Cys Leu Met Pro Ala Val 
                165                 170                 175     
Gln Asn Trp Leu Val Glu Val Pro Thr Val Ser Pro Ile Ser Arg Phe 
            180                 185                 190         
Thr Tyr His Met Val Ser Gly Met Ser Leu Arg Pro Arg Val Asn Tyr 
        195                 200                 205             
Leu Gln Asp Phe Ser Tyr Gln Arg Ser Leu Lys Phe Arg Pro Lys Gly 
    210                 215                 220                 
Lys Pro Cys Pro Lys Glu Ile Pro Lys Glu Ser Lys Asn Thr Glu Val 
225                 230                 235                 240 
Leu Val Trp Glu Glu Cys Val Ala Asn Ser Ala Val Ile Leu Gln Asn 
                245                 250                 255     
Asn Glu Phe Gly Thr Leu Ile Asp Trp Ala Pro Arg Gly Gln Phe Tyr 
            260                 265                 270         
His Asn Cys Ser Gly Gln Thr Gln Ser Cys Pro Ser Ala Gln Val Ser 
        275                 280                 285             
Pro Ala Val Asp Ser Asp Leu Thr Glu Ser Leu Asp Lys His Lys His 
    290                 295                 300                 
Lys Lys Leu Gln Ser Phe Tyr Pro Trp Glu Trp Gly Glu Lys Gly Ile 
305                 310                 315                 320 
Ser Thr Ala Arg Pro Lys Ile Ile Ser Pro Val Ser Gly Pro Glu His 
                325                 330                 335     
Pro Glu Leu Trp Arg Leu Thr Val Ala Ser His His Ile Arg Ile Trp 
            340                 345                 350         
Ser Gly Asn Gln Thr Leu Glu Thr Arg Asp Arg Lys Pro Phe Tyr Thr 
        355                 360                 365             
Ile Asp Leu Asn Ser Ser Leu Thr Val Pro Leu Gln Ser Cys Val Lys 
    370                 375                 380                 
Pro Pro Tyr Met Leu Val Val Gly Asn Ile Val Ile Lys Pro Asp Ser 
385                 390                 395                 400 
Gln Thr Ile Thr Cys Glu Asn Cys Arg Leu Leu Thr Cys Ile Asp Ser 
                405                 410                 415     
Thr Phe Asn Trp Gln His Arg Ile Leu Leu Val Arg Ala Arg Glu Gly 
            420                 425                 430         
Val Trp Ile Pro Val Ser Met Asp Arg Pro Trp Glu Ala Ser Pro Ser 
        435                 440                 445             
Val His Ile Leu Thr Glu Val Leu Lys Gly Val Leu Asn Arg Ser Lys 
    450                 455                 460                 
Arg Phe Ile Phe Thr Leu Ile Ala Val Ile Met Gly Leu Ile Ala Val 
465                 470                 475                 480 
Thr Ala Thr Ala Ala Val Ala Gly Val Ala Leu His Ser Ser Val Gln 
                485                 490                 495     
Ser Val Asn Phe Val Asn Asp Trp Gln Asn Asn Ser Thr Arg Leu Trp 
            500                 505                 510         
Asn Ser Gln Ser Ser Ile Asp Gln Lys Leu Ala Asn Gln Ile Asn Asp 
        515                 520                 525             
Leu Arg Gln Thr Val Ile Trp Met Gly Asp Arg Leu Met Ser Leu Glu 
    530                 535                 540                 
His Arg Phe Gln Leu Gln Cys Asp Trp Asn Thr Ser Asp Phe Cys Ile 
545                 550                 555                 560 
Thr Pro Gln Ile Tyr Asn Glu Ser Glu His His Trp Asp Met Val Arg 
                565                 570                 575     
Cys His Leu Gln Gly Arg Glu Asp Asn Leu Thr Leu Asp Ile Ser Lys 
            580                 585                 590         
Leu Lys Glu Gln Ile Phe Glu Ala Ser Lys Ala His Leu Asn Leu Val 
        595                 600                 605             
Pro Gly Thr Glu Ala Ile Ala Gly Val Ala Asp Gly Leu Ala Asn Leu 
    610                 615                 620                 
Asn Thr Val Thr Trp Val Lys Thr Ile Gly Ser Thr Thr Ile Ile Asn 
625                 630                 635                 640 
Leu Ile Leu Ile Leu Val Cys Leu Phe Cys Leu Leu Leu Val Tyr Arg 
                645                 650                 655     
Cys Thr Gln Gln Leu Arg Arg Asp Ser Asp His Arg Glu Arg Ala Met 
            660                 665                 670         
Met Thr Met Val Val Leu Ser Lys Arg Lys Gly Gly Asn Val Gly Lys 
        675                 680                 685             
Ser Lys Arg Asp Gln Ile Val Thr Val Ser Val 
    690                 695                 

<210> 18
<211> 666
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 18
Met Gly Gln Thr Lys Ser Lys Ile Lys Ser Lys Tyr Ala Ser Tyr Leu 
1               5                   10                  15      
Ser Phe Ile Lys Ile Leu Leu Lys Arg Gly Gly Val Lys Val Ser Thr 
            20                  25                  30          
Lys Asn Leu Ile Lys Leu Phe Gln Ile Ile Glu Gln Phe Cys Pro Trp 
        35                  40                  45              
Phe Pro Glu Gln Gly Thr Leu Asp Leu Lys Asp Trp Lys Arg Ile Gly 
    50                  55                  60                  
Lys Glu Leu Lys Gln Ala Gly Arg Lys Gly Asn Ile Ile Pro Leu Thr 
65                  70                  75                  80  
Val Trp Asn Asp Trp Ala Ile Ile Lys Ala Ala Leu Glu Pro Phe Gln 
                85                  90                  95      
Thr Glu Glu Asp Ser Val Ser Val Ser Asp Ala Pro Gly Ser Cys Ile 
            100                 105                 110         
Ile Asp Cys Asn Glu Lys Thr Arg Lys Lys Ser Gln Lys Glu Thr Glu 
        115                 120                 125             
Ser Leu His Cys Glu Tyr Val Ala Glu Pro Val Met Ala Gln Ser Thr 
    130                 135                 140                 
Gln Asn Ala Asp Tyr Asn Gln Leu Gln Glu Val Ile Tyr Pro Glu Thr 
145                 150                 155                 160 
Leu Lys Leu Glu Gly Lys Gly Pro Glu Leu Met Gly Pro Ser Glu Ser 
                165                 170                 175     
Lys Pro Arg Gly Thr Ser Pro Leu Pro Ala Gly Gln Val Pro Val Thr 
            180                 185                 190         
Leu Gln Pro Gln Lys Gln Val Lys Glu Asn Lys Thr Gln Pro Pro Val 
        195                 200                 205             
Ala Tyr Gln Tyr Trp Pro Pro Ala Glu Leu Gln Tyr Gln Pro Pro Pro 
    210                 215                 220                 
Glu Ser Gln Tyr Gly Tyr Pro Gly Met Pro Pro Ala Pro Gln Gly Arg 
225                 230                 235                 240 
Ala Pro Tyr Pro Gln Pro Pro Thr Arg Arg Leu Asn Pro Thr Ala Pro 
                245                 250                 255     
Pro Ser Arg Gln Gly Ser Glu Leu His Glu Ile Ile Asp Lys Ser Arg 
            260                 265                 270         
Lys Glu Gly Asp Thr Glu Ala Trp Gln Phe Pro Val Thr Leu Glu Leu 
        275                 280                 285             
Met Pro Pro Gly Glu Gly Ala Gln Glu Gly Glu Pro Pro Thr Val Glu 
    290                 295                 300                 
Ala Arg Tyr Lys Ser Phe Ser Ile Lys Met Leu Lys Asp Met Lys Glu 
305                 310                 315                 320 
Gly Val Lys Gln Tyr Gly Pro Asn Ser Pro Tyr Met Arg Thr Leu Leu 
                325                 330                 335     
Asp Ser Ile Ala His Gly His Arg Leu Ile Pro Tyr Asp Trp Glu Ile 
            340                 345                 350         
Leu Ala Lys Ser Ser Leu Ser Pro Ser Gln Phe Leu Gln Phe Lys Thr 
        355                 360                 365             
Trp Trp Ile Asp Gly Val Gln Glu Gln Val Arg Arg Asn Arg Ala Ala 
    370                 375                 380                 
Asn Pro Pro Val Asn Ile Asp Ala Asp Gln Leu Leu Gly Ile Gly Gln 
385                 390                 395                 400 
Asn Trp Ser Thr Ile Ser Gln Gln Ala Leu Met Gln Asn Glu Ala Ile 
                405                 410                 415     
Glu Gln Val Arg Ala Ile Cys Leu Arg Ala Trp Glu Lys Ile Gln Asp 
            420                 425                 430         
Pro Gly Ser Thr Cys Pro Ser Phe Asn Thr Val Arg Gln Gly Ser Lys 
        435                 440                 445             
Glu Pro Tyr Pro Asp Phe Val Ala Arg Leu Gln Asp Val Ala Gln Lys 
    450                 455                 460                 
Ser Ile Ala Asp Glu Lys Ala Arg Lys Val Ile Val Glu Leu Met Ala 
465                 470                 475                 480 
Tyr Glu Asn Ala Asn Pro Glu Cys Gln Ser Ala Ile Lys Pro Leu Lys 
                485                 490                 495     
Gly Lys Val Pro Ala Gly Ser Asp Val Ile Ser Glu Tyr Val Lys Ala 
            500                 505                 510         
Cys Asp Gly Met Gly Gly Ala Met His Lys Ala Met Leu Met Ala Gln 
        515                 520                 525             
Ala Ile Thr Gly Val Val Leu Gly Gly Gln Val Arg Thr Phe Gly Gly 
    530                 535                 540                 
Lys Cys Tyr Asn Cys Gly Gln Ile Gly His Leu Lys Lys Asn Cys Pro 
545                 550                 555                 560 
Val Leu Asn Lys Gln Asn Ile Thr Ile Gln Ala Thr Thr Thr Gly Arg 
                565                 570                 575     
Glu Pro Pro Asp Leu Cys Pro Arg Cys Lys Lys Gly Lys His Trp Ala 
            580                 585                 590         
Ser Gln Cys Arg Ser Lys Phe Asp Lys Asn Gly Gln Pro Leu Ser Gly 
        595                 600                 605             
Asn Glu Gln Arg Gly Gln Pro Gln Ala Pro Gln Gln Thr Gly Ala Phe 
    610                 615                 620                 
Pro Ile Gln Pro Phe Val Pro Gln Gly Phe Gln Gly Gln Gln Pro Pro 
625                 630                 635                 640 
Leu Ser Gln Val Phe Gln Gly Ile Ser Gln Leu Pro Gln Tyr Asn Asn 
                645                 650                 655     
Cys Pro Pro Pro Gln Ala Ala Val Gln Gln 
            660                 665     

<210> 19
<211> 698
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 19
Met His Pro Ser Glu Met Gln Arg Lys Ala Pro Pro Arg Arg Arg Arg 
1               5                   10                  15      
His Arg Asn Arg Ala Pro Leu Thr His Lys Met Asn Lys Met Val Thr 
            20                  25                  30          
Ser Glu Gln Met Lys Leu Pro Ser Thr Lys Lys Ala Glu Pro Pro Thr 
        35                  40                  45              
Trp Ala Gln Leu Lys Lys Leu Thr Gln Leu Ala Thr Lys Tyr Leu Glu 
    50                  55                  60                  
Asn Thr Lys Val Thr Gln Thr Pro Glu Ser Met Leu Leu Ala Ala Leu 
65                  70                  75                  80  
Met Ile Val Ser Met Val Val Ser Leu Pro Met Pro Ala Gly Ala Ala 
                85                  90                  95      
Ala Ala Asn Tyr Thr Asn Trp Ala Tyr Val Pro Phe Pro Pro Leu Ile 
            100                 105                 110         
Arg Ala Val Thr Trp Met Asp Asn Pro Ile Glu Val Tyr Val Asn Asp 
        115                 120                 125             
Ser Val Trp Val His Gly Pro Ile Asp Asp Arg Cys Pro Ala Lys Pro 
    130                 135                 140                 
Glu Glu Glu Gly Met Met Ile Asn Ile Ser Ile Gly Tyr His Tyr Pro 
145                 150                 155                 160 
Pro Ile Cys Leu Gly Arg Ala Pro Gly Cys Leu Met Pro Ala Val Gln 
                165                 170                 175     
Asn Trp Leu Val Glu Val Pro Thr Val Ser Pro Ile Ser Arg Phe Thr 
            180                 185                 190         
Tyr Asn Met Val Ser Gly Met Ser Leu Arg Pro Arg Val Asn Tyr Leu 
        195                 200                 205             
Gln Asp Phe Ser Tyr Gln Arg Ser Leu Lys Phe Arg Pro Lys Gly Lys 
    210                 215                 220                 
Pro Cys Pro Lys Glu Ile Pro Lys Glu Ser Lys Asn Thr Glu Val Leu 
225                 230                 235                 240 
Val Trp Glu Glu Cys Val Ala Asn Ser Val Val Ile Leu Gln Asn Asn 
                245                 250                 255     
Glu Phe Gly Thr Ile Ile Asp Trp Ala Pro Arg Gly Gln Phe Tyr His 
            260                 265                 270         
Asn Cys Ser Gly Gln Thr Gln Ser Cys Pro Ser Ala Gln Val Ser Pro 
        275                 280                 285             
Ala Val Asp Ser Asp Leu Thr Glu Ser Leu Asp Lys His Lys His Lys 
    290                 295                 300                 
Lys Leu Gln Ser Phe Tyr Pro Trp Glu Trp Gly Glu Lys Gly Ile Ser 
305                 310                 315                 320 
Thr Pro Arg Pro Lys Ile Ile Ser Pro Val Ser Gly Pro Glu His Pro 
                325                 330                 335     
Glu Leu Trp Arg Leu Thr Val Ala Ser His His Ile Arg Ile Trp Ser 
            340                 345                 350         
Gly Asn Gln Thr Leu Glu Thr Arg Asp Arg Lys Pro Phe Tyr Thr Val 
        355                 360                 365             
Asp Leu Asn Ser Ser Leu Thr Val Pro Leu Gln Ser Cys Val Lys Pro 
    370                 375                 380                 
Pro Tyr Met Leu Val Val Gly Asn Ile Val Ile Lys Pro Asp Ser Gln 
385                 390                 395                 400 
Thr Ile Thr Cys Glu Asn Cys Arg Leu Leu Thr Cys Ile Asp Ser Thr 
                405                 410                 415     
Phe Asn Trp Gln His Arg Ile Leu Leu Val Arg Ala Arg Glu Gly Val 
            420                 425                 430         
Trp Ile Pro Val Ser Met Asp Arg Pro Trp Glu Ala Ser Pro Ser Ile 
        435                 440                 445             
His Ile Leu Thr Glu Val Leu Lys Gly Val Leu Asn Arg Ser Lys Arg 
    450                 455                 460                 
Phe Ile Phe Thr Leu Ile Ala Val Ile Met Gly Leu Ile Ala Val Thr 
465                 470                 475                 480 
Ala Met Ala Ala Val Ala Gly Val Ala Leu His Ser Phe Val Gln Ser 
                485                 490                 495     
Val Asn Phe Val Asn Asp Trp Gln Lys Asn Ser Thr Arg Leu Trp Asn 
            500                 505                 510         
Ser Gln Ser Ser Ile Asp Gln Lys Leu Ala Asn Gln Ile Asn Asp Leu 
        515                 520                 525             
Arg Gln Thr Val Ile Trp Met Gly Asp Arg Leu Met Ser Leu Glu His 
    530                 535                 540                 
Arg Phe Gln Leu Gln Cys Asp Trp Asn Thr Ser Asp Phe Cys Ile Thr 
545                 550                 555                 560 
Pro Gln Ile Tyr Asn Glu Ser Glu His His Trp Asp Met Val Arg Arg 
                565                 570                 575     
His Leu Gln Gly Arg Glu Asp Asn Leu Thr Leu Asp Ile Ser Lys Leu 
            580                 585                 590         
Lys Glu Gln Ile Phe Glu Ala Ser Lys Ala His Leu Asn Leu Val Pro 
        595                 600                 605             
Gly Thr Glu Ala Ile Ala Gly Val Ala Asp Gly Leu Ala Asn Leu Asn 
    610                 615                 620                 
Pro Val Thr Trp Val Lys Thr Ile Gly Ser Thr Thr Ile Ile Asn Leu 
625                 630                 635                 640 
Ile Leu Ile Leu Val Cys Leu Phe Cys Leu Leu Leu Val Cys Arg Cys 
                645                 650                 655     
Thr Gln Gln Leu Arg Arg Asp Ser Asp His Arg Glu Arg Ala Met Met 
            660                 665                 670         
Thr Met Val Val Leu Ser Lys Arg Lys Gly Gly Asn Val Gly Lys Ser 
        675                 680                 685             
Lys Arg Asp Gln Ile Val Thr Val Ser Val 
    690                 695             

<210> 20
<211> 666
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 20
Met Gly Gln Thr Lys Ser Lys Ile Lys Ser Lys Tyr Ala Ser Tyr Leu 
1               5                   10                  15      
Ser Phe Ile Lys Ile Leu Leu Lys Arg Gly Gly Val Lys Val Ser Thr 
            20                  25                  30          
Lys Asn Leu Ile Lys Leu Phe Gln Ile Ile Glu Gln Phe Cys Pro Trp 
        35                  40                  45              
Phe Pro Glu Gln Gly Thr Leu Asp Leu Lys Asp Trp Lys Arg Ile Gly 
    50                  55                  60                  
Lys Glu Leu Lys Gln Ala Gly Arg Lys Gly Asn Ile Ile Pro Leu Thr 
65                  70                  75                  80  
Val Trp Asn Asp Trp Ala Ile Ile Lys Ala Ala Leu Glu Pro Phe Gln 
                85                  90                  95      
Thr Glu Glu Asp Ser Ile Ser Val Ser Asp Ala Pro Gly Ser Cys Ile 
            100                 105                 110         
Ile Asp Cys Asn Glu Asn Thr Arg Lys Lys Ser Gln Lys Glu Thr Glu 
        115                 120                 125             
Gly Leu His Cys Glu Tyr Ala Ala Glu Pro Val Met Ala Gln Ser Thr 
    130                 135                 140                 
Gln Asn Val Asp Tyr Asn Gln Leu Gln Glu Val Ile Tyr Pro Glu Thr 
145                 150                 155                 160 
Leu Lys Leu Glu Gly Lys Gly Pro Glu Leu Val Gly Pro Ser Glu Ser 
                165                 170                 175     
Lys Pro Arg Gly Thr Ser Pro Leu Pro Ala Gly Gln Val Pro Val Thr 
            180                 185                 190         
Leu Gln Pro Gln Thr Gln Val Lys Glu Asn Lys Thr Gln Pro Pro Val 
        195                 200                 205             
Ala Tyr Gln Tyr Trp Pro Pro Ala Glu Leu Gln Tyr Arg Pro Pro Pro 
    210                 215                 220                 
Glu Ser Gln Tyr Gly Tyr Pro Gly Met Pro Pro Ala Pro Gln Gly Arg 
225                 230                 235                 240 
Ala Pro Tyr Pro Gln Pro Pro Thr Arg Arg Leu Asn Pro Thr Ala Pro 
                245                 250                 255     
Pro Ser Arg Gln Gly Ser Glu Leu His Glu Ile Ile Asp Lys Ser Arg 
            260                 265                 270         
Lys Glu Gly Asp Thr Glu Ala Trp Gln Phe Pro Val Met Leu Glu Pro 
        275                 280                 285             
Met Pro Pro Gly Glu Gly Ala Gln Glu Gly Glu Pro Pro Thr Val Glu 
    290                 295                 300                 
Ala Arg Tyr Lys Ser Phe Ser Ile Lys Met Leu Lys Asp Met Lys Glu 
305                 310                 315                 320 
Gly Val Lys Gln Tyr Gly Pro Asn Ser Pro Tyr Met Arg Thr Leu Leu 
                325                 330                 335     
Asp Ser Ile Ala His Gly His Arg Leu Ile Pro Tyr Asp Trp Glu Ile 
            340                 345                 350         
Leu Ala Lys Ser Ser Leu Leu Pro Ser Gln Phe Leu Gln Phe Lys Thr 
        355                 360                 365             
Trp Trp Ile Asp Gly Val Gln Glu Gln Val Gln Arg Asn Arg Ala Ala 
    370                 375                 380                 
Asn Pro Pro Val Asn Ile Asp Ala Asp Gln Leu Leu Gly Ile Gly Gln 
385                 390                 395                 400 
Asn Trp Ser Thr Ile Ser Gln Gln Ala Leu Met Gln Asn Glu Ala Ile 
                405                 410                 415     
Glu Gln Val Arg Ala Ile Cys Leu Arg Ala Trp Glu Lys Ile Gln Asp 
            420                 425                 430         
Pro Gly Ser Thr Cys Pro Ser Phe Asn Thr Val Arg Gln Ser Ser Lys 
        435                 440                 445             
Glu Pro Tyr Pro Asp Phe Val Ala Arg Leu Gln Asp Val Ala Gln Lys 
    450                 455                 460                 
Ser Ile Ala Asp Glu Lys Ala Arg Lys Val Ile Val Glu Leu Met Ala 
465                 470                 475                 480 
Tyr Glu Asn Ala Asn Pro Glu Cys Gln Ser Ala Ile Lys Pro Leu Lys 
                485                 490                 495     
Gly Lys Val Pro Ala Gly Ser Asp Val Ile Ser Glu Tyr Val Lys Ala 
            500                 505                 510         
Cys Asp Gly Ile Gly Gly Ala Met His Lys Ala Met Leu Met Ala Gln 
        515                 520                 525             
Ala Ile Thr Gly Val Val Leu Gly Gly Gln Val Arg Thr Phe Gly Gly 
    530                 535                 540                 
Lys Cys Tyr Asn Cys Gly Gln Ile Gly His Leu Lys Lys Asn Cys Pro 
545                 550                 555                 560 
Val Leu Asn Lys Gln Asn Ile Thr Ile Gln Ala Thr Thr Thr Gly Arg 
                565                 570                 575     
Glu Pro Pro Asp Leu Cys Pro Arg Cys Lys Lys Gly Lys His Trp Ala 
            580                 585                 590         
Ser Gln Cys Arg Ser Lys Phe Asp Lys Asn Gly Gln Pro Leu Ser Gly 
        595                 600                 605             
Asn Glu Gln Arg Gly Gln Pro Gln Ala Pro Gln Gln Thr Gly Ala Phe 
    610                 615                 620                 
Pro Ile Gln Pro Phe Val Pro Gln Gly Phe Gln Gly Gln Gln Pro Pro 
625                 630                 635                 640 
Leu Ser Gln Val Phe Gln Gly Ile Ser Gln Leu Pro Gln Tyr Asn Asn 
                645                 650                 655     
Cys Pro Pro Pro Gln Ala Ala Val Gln Gln 
            660                 665     

<210> 21
<211> 661
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 21
Met Asn Pro Ser Glu Met Gln Arg Lys Ala Pro Pro Arg Arg Arg Arg 
1               5                   10                  15      
His Arg Asn Arg Ala Pro Leu Thr His Lys Met Asn Lys Met Val Thr 
            20                  25                  30          
Ser Glu Glu Gln Met Lys Leu Pro Ser Thr Lys Lys Ala Glu Pro Pro 
        35                  40                  45              
Thr Trp Ala Gln Leu Lys Lys Leu Thr Gln Leu Ala Thr Lys Tyr Leu 
    50                  55                  60                  
Glu Asn Thr Lys Val Thr Gln Thr Pro Glu Ser Met Leu Leu Ala Ala 
65                  70                  75                  80  
Leu Met Ile Val Ser Met Val Val Ser Leu Pro Met Pro Ala Gly Ala 
                85                  90                  95      
Ala Ala Ala Asn Tyr Thr Tyr Trp Ala Tyr Val Pro Phe Pro Pro Leu 
            100                 105                 110         
Ile Arg Ala Val Thr Trp Met Asp Asn Pro Ile Glu Val Tyr Val Asn 
        115                 120                 125             
Asp Ser Val Trp Val Pro Gly Pro Ile Asp Asp Arg Cys Pro Ala Lys 
    130                 135                 140                 
Pro Glu Glu Glu Gly Met Met Ile Asn Ile Ser Ile Gly Tyr Arg Tyr 
145                 150                 155                 160 
Pro Pro Ile Cys Leu Gly Thr Ala Pro Gly Cys Leu Met Pro Ala Val 
                165                 170                 175     
Gln Asn Trp Leu Val Glu Val Pro Ile Val Ser Pro Ile Ser Arg Phe 
            180                 185                 190         
Thr Tyr His Met Val Ser Gly Met Ser Leu Arg Pro Arg Val Asn Tyr 
        195                 200                 205             
Leu Gln Asp Phe Ser Tyr Gln Arg Ser Leu Lys Phe Arg Pro Lys Gly 
    210                 215                 220                 
Lys Pro Cys Pro Lys Glu Ile Pro Lys Glu Ser Lys Asn Thr Glu Val 
225                 230                 235                 240 
Leu Val Trp Glu Glu Cys Val Ala Asn Ser Ala Val Ile Leu Gln Asn 
                245                 250                 255     
Asn Glu Phe Gly Thr Ile Ile Asp Trp Ala Pro Arg Gly Gln Phe Tyr 
            260                 265                 270         
His Asn Cys Ser Gly Gln Thr Gln Ser Cys Pro Ser Ala Gln Val Ser 
        275                 280                 285             
Pro Ala Val Asp Ser Asp Leu Thr Glu Ser Leu Asp Lys His Lys His 
    290                 295                 300                 
Lys Lys Leu Gln Ser Phe Tyr Pro Trp Glu Trp Gly Glu Lys Gly Ile 
305                 310                 315                 320 
Ser Thr Pro Arg Pro Lys Ile Val Ser Pro Val Ser Gly Pro Glu His 
                325                 330                 335     
Pro Glu Leu Trp Arg Leu Thr Val Ala Ser His His Ile Arg Ile Trp 
            340                 345                 350         
Ser Gly Asn Gln Thr Leu Glu Thr Arg Asp Arg Lys Pro Phe Tyr Thr 
        355                 360                 365             
Val Asp Leu Asn Ser Ser Leu Thr Val Pro Leu Gln Ser Cys Val Lys 
    370                 375                 380                 
Pro Pro Tyr Met Leu Val Val Gly Asn Ile Val Ile Lys Pro Asp Ser 
385                 390                 395                 400 
Gln Thr Ile Thr Cys Glu Asn Cys Arg Leu Leu Thr Cys Ile Asp Ser 
                405                 410                 415     
Thr Phe Asn Trp Gln His Arg Ile Leu Leu Val Arg Ala Arg Glu Gly 
            420                 425                 430         
Val Trp Ile Pro Val Ser Met Asp Arg Pro Trp Glu Ala Ser Pro Ser 
        435                 440                 445             
Ile His Ile Leu Thr Glu Val Leu Lys Gly Val Leu Asn Arg Ser Lys 
    450                 455                 460                 
Arg Phe Ile Phe Thr Leu Ile Ala Val Ile Met Gly Leu Ile Ala Val 
465                 470                 475                 480 
Thr Ala Thr Gly Ala Val Ala Gly Val Ala Leu His Ser Ser Val Gln 
                485                 490                 495     
Ser Val Asn Phe Val Asn Asp Trp Gln Lys Asn Ser Thr Arg Leu Trp 
            500                 505                 510         
Asn Ser Gln Ser Ser Ile Asp Gln Lys Leu Ala Asn Gln Ile Asn Asp 
        515                 520                 525             
Leu Arg Gln Thr Val Ile Trp Met Gly Asp Arg Leu Met Ser Leu Glu 
    530                 535                 540                 
His Arg Phe Gln Leu Gln Cys Asp Trp Asn Thr Ser Asp Phe Cys Ile 
545                 550                 555                 560 
Thr Pro Gln Ile Tyr Asn Glu Ser Glu His His Trp Asp Met Val Arg 
                565                 570                 575     
Arg His Leu Gln Gly Arg Glu Asp Asn Leu Thr Leu Asp Ile Ser Lys 
            580                 585                 590         
Leu Lys Glu Gln Ile Phe Lys Ala Ser Lys Ala His Leu Asn Leu Val 
        595                 600                 605             
Pro Gly Thr Glu Ala Ile Ala Gly Val Ala Asp Gly Leu Ala Asn Leu 
    610                 615                 620                 
Asn Pro Val Thr Trp Val Lys Thr Ile Gly Ser Thr Thr Ile Ile Asn 
625                 630                 635                 640 
Leu Ile Leu Ile Leu Val Cys Leu Phe Cys Leu Leu Leu Val Cys Arg 
                645                 650                 655     
Cys Thr Gln Gln Leu 
            660     

<210> 22
<211> 588
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 22
Met Val Thr Pro Val Thr Trp Met Asp Asn Pro Ile Glu Ile Tyr Val 
1               5                   10                  15      
Asn Asp Ser Val Trp Val Pro Gly Pro Ile Asp Asp Arg Cys Pro Ala 
            20                  25                  30          
Lys Pro Glu Glu Glu Gly Met Met Ile Asn Ile Ser Ile Gly Tyr Arg 
        35                  40                  45              
Tyr Pro Pro Ile Cys Leu Gly Arg Ala Pro Gly Cys Leu Met Pro Ala 
    50                  55                  60                  
Val Gln Asn Trp Leu Val Glu Val Pro Thr Val Ser Pro Ile Ser Arg 
65                  70                  75                  80  
Phe Thr Tyr His Met Val Ser Gly Met Ser Leu Arg Pro Arg Val Asn 
                85                  90                  95      
Tyr Leu Gln Asp Phe Ser Tyr Gln Arg Ser Leu Lys Phe Arg Pro Lys 
            100                 105                 110         
Gly Lys Pro Cys Pro Lys Glu Ile Pro Lys Glu Ser Lys Asn Thr Glu 
        115                 120                 125             
Val Leu Val Trp Glu Glu Cys Val Ala Asn Ser Ala Val Ile Leu Gln 
    130                 135                 140                 
Asn Asn Glu Phe Gly Thr Ile Ile Asp Trp Ala Pro Arg Gly Gln Phe 
145                 150                 155                 160 
Tyr His Asn Cys Ser Gly Gln Thr Gln Ser Cys Pro Ser Ala Gln Val 
                165                 170                 175     
Ser Pro Ala Val Asp Ser Asp Leu Thr Glu Ser Leu Asp Lys His Lys 
            180                 185                 190         
His Lys Lys Leu Gln Ser Phe Tyr Pro Trp Glu Trp Gly Glu Lys Arg 
        195                 200                 205             
Ile Ser Thr Pro Arg Pro Lys Ile Val Ser Pro Val Ser Gly Pro Glu 
    210                 215                 220                 
His Pro Glu Leu Trp Arg Leu Thr Val Ala Ser His His Ile Arg Ile 
225                 230                 235                 240 
Trp Ser Gly Asn Gln Thr Leu Glu Thr Arg Asp Cys Lys Pro Phe Tyr 
                245                 250                 255     
Thr Ile Asp Leu Asn Ser Ser Leu Thr Val Pro Leu Gln Ser Cys Val 
            260                 265                 270         
Lys Pro Pro Tyr Met Leu Val Val Gly Asn Ile Val Ile Lys Pro Asp 
        275                 280                 285             
Ser Gln Thr Ile Thr Cys Glu Asn Cys Arg Leu Leu Ser Cys Ile Asp 
    290                 295                 300                 
Ser Thr Phe Asn Trp Gln His Arg Ile Leu Leu Val Arg Ala Arg Glu 
305                 310                 315                 320 
Gly Val Trp Ile Pro Val Ser Met Asp Arg Pro Trp Glu Ala Ser Pro 
                325                 330                 335     
Ser Val His Ile Leu Thr Glu Val Leu Lys Gly Val Leu Asn Arg Ser 
            340                 345                 350         
Lys Arg Phe Ile Phe Thr Leu Ile Ala Val Ile Met Gly Leu Ile Ala 
        355                 360                 365             
Val Thr Ala Thr Ala Ala Val Ala Gly Val Ala Leu His Ser Ser Val 
    370                 375                 380                 
Gln Ser Val Asn Phe Val Asn Asp Trp Gln Lys Asn Ser Thr Arg Leu 
385                 390                 395                 400 
Trp Asn Ser Gln Ser Ser Ile Asp Gln Lys Leu Ala Asn Gln Ile Asn 
                405                 410                 415     
Asp Leu Arg Gln Thr Val Ile Trp Met Gly Asp Arg Leu Met Ser Leu 
            420                 425                 430         
Glu His Arg Phe Gln Leu Gln Cys Asp Trp Asn Thr Ser Asp Phe Cys 
        435                 440                 445             
Ile Thr Pro Gln Ile Tyr Asn Glu Ser Glu His His Trp Asp Met Val 
    450                 455                 460                 
Arg Arg His Leu Gln Gly Arg Glu Asp Asn Leu Thr Leu Asp Ile Ser 
465                 470                 475                 480 
Lys Leu Lys Glu Gln Ile Phe Glu Ala Ser Lys Ala His Leu Asn Leu 
                485                 490                 495     
Val Pro Gly Thr Glu Ala Ile Ala Gly Val Ala Asp Gly Leu Ala Asn 
            500                 505                 510         
Leu Asn Pro Val Thr Trp Val Lys Thr Ile Gly Ser Thr Thr Ile Ile 
        515                 520                 525             
Asn Leu Ile Leu Ile Leu Val Cys Leu Phe Cys Leu Leu Leu Val Cys 
    530                 535                 540                 
Arg Cys Thr Gln Gln Leu Arg Arg Asp Ser Asp His Arg Glu Arg Ala 
545                 550                 555                 560 
Met Met Thr Met Ala Val Leu Ser Lys Arg Lys Gly Gly Asn Val Gly 
                565                 570                 575     
Lys Ser Lys Arg Asp Gln Ile Val Thr Val Ser Val 
            580                 585             

<210> 23
<211> 666
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 23
Met Gly Gln Thr Lys Ser Lys Ile Lys Ser Lys Tyr Ala Ser Tyr Leu 
1               5                   10                  15      
Ser Phe Ile Lys Ile Leu Leu Lys Arg Gly Gly Val Lys Val Ser Thr 
            20                  25                  30          
Lys Asn Leu Ile Lys Leu Phe Gln Ile Ile Glu Gln Phe Cys Pro Trp 
        35                  40                  45              
Phe Pro Glu Gln Gly Thr Leu Asp Leu Lys Asp Trp Lys Arg Ile Gly 
    50                  55                  60                  
Lys Glu Leu Lys Gln Ala Gly Arg Lys Gly Asn Ile Ile Pro Leu Thr 
65                  70                  75                  80  
Val Trp Asn Asp Trp Ala Ile Ile Lys Ala Ala Leu Glu Pro Phe Gln 
                85                  90                  95      
Thr Glu Lys Asp Ser Val Ser Val Ser Asp Ala Leu Gly Ser Cys Ile 
            100                 105                 110         
Ile Asp Cys Asn Glu Asn Thr Arg Lys Lys Ser Gln Lys Glu Thr Glu 
        115                 120                 125             
Gly Leu His Cys Glu Tyr Val Ala Glu Pro Val Met Ala Gln Ser Thr 
    130                 135                 140                 
Gln Asn Val Asp Tyr Asn Gln Leu Gln Glu Val Ile Tyr Pro Glu Thr 
145                 150                 155                 160 
Leu Lys Leu Glu Gly Lys Gly Pro Glu Leu Val Gly Pro Ser Glu Ser 
                165                 170                 175     
Lys Pro Arg Gly Thr Ser His Leu Pro Ala Gly Gln Val Pro Val Thr 
            180                 185                 190         
Leu Gln Pro Gln Lys Gln Val Lys Glu Asn Lys Thr Gln Pro Pro Val 
        195                 200                 205             
Ala Tyr Gln Tyr Trp Pro Pro Ala Glu Leu Gln Tyr Arg Pro Pro Pro 
    210                 215                 220                 
Glu Ser Gln Tyr Gly Tyr Pro Gly Met Pro Pro Ala Pro Gln Gly Arg 
225                 230                 235                 240 
Ala Pro Tyr Pro Gln Pro Pro Thr Arg Arg Leu Asn Pro Thr Ala Pro 
                245                 250                 255     
Pro Ser Arg Gln Gly Ser Glu Leu His Glu Ile Ile Asp Lys Ser Arg 
            260                 265                 270         
Lys Glu Gly Asp Thr Glu Ala Trp Gln Phe Pro Val Thr Leu Glu Pro 
        275                 280                 285             
Met Pro Pro Gly Glu Gly Ala Gln Glu Gly Glu Pro Pro Thr Val Glu 
    290                 295                 300                 
Ala Arg Tyr Lys Ser Phe Ser Ile Lys Met Leu Lys Asp Met Lys Glu 
305                 310                 315                 320 
Gly Val Lys Gln Tyr Gly Pro Asn Ser Pro Tyr Met Arg Thr Leu Leu 
                325                 330                 335     
Asp Ser Ile Ala His Gly His Arg Leu Ile Pro Tyr Asp Trp Glu Ile 
            340                 345                 350         
Leu Ala Lys Ser Ser Leu Ser Pro Ser Gln Phe Leu Gln Phe Lys Thr 
        355                 360                 365             
Trp Trp Ile Asp Gly Val Gln Glu Gln Val Arg Arg Asn Arg Ala Ala 
    370                 375                 380                 
Asn Pro Pro Val Asn Ile Asp Ala Asp Gln Leu Leu Gly Ile Gly Gln 
385                 390                 395                 400 
Asn Trp Ser Thr Ile Ser Gln Gln Ala Leu Met Gln Asn Glu Ala Ile 
                405                 410                 415     
Glu Gln Val Arg Ala Ile Cys Leu Arg Ala Trp Glu Lys Ile Gln Asp 
            420                 425                 430         
Pro Gly Ser Thr Cys Pro Ser Phe Asn Thr Val Arg Gln Gly Ser Lys 
        435                 440                 445             
Glu Pro Tyr Pro Asp Phe Val Ala Arg Leu Gln Asp Val Ala Gln Lys 
    450                 455                 460                 
Ser Ile Ala Asp Glu Lys Ala Arg Lys Val Ile Val Glu Leu Met Ala 
465                 470                 475                 480 
Tyr Glu Asn Ala Asn Pro Glu Cys Gln Ser Ala Ile Lys Pro Leu Lys 
                485                 490                 495     
Gly Lys Val Pro Ala Gly Ser Asp Val Ile Ser Glu Tyr Val Lys Ala 
            500                 505                 510         
Cys Asp Gly Ile Gly Gly Ala Met His Lys Ala Met Leu Met Ala Gln 
        515                 520                 525             
Ala Ile Thr Gly Val Val Leu Gly Gly Gln Val Arg Thr Phe Gly Gly 
    530                 535                 540                 
Lys Cys Tyr Asn Cys Gly Gln Ile Gly His Leu Lys Lys Asn Cys Pro 
545                 550                 555                 560 
Val Leu Asn Lys Gln Asn Ile Thr Ile Gln Ala Thr Thr Thr Gly Arg 
                565                 570                 575     
Glu Pro Pro Asp Leu Cys Pro Arg Cys Lys Lys Gly Lys His Trp Ala 
            580                 585                 590         
Ser Gln Cys Arg Ser Lys Phe Asp Lys Asn Gly Gln Pro Leu Ser Gly 
        595                 600                 605             
Asn Glu Gln Arg Gly Gln Pro Gln Ala Pro Gln Gln Thr Gly Ala Phe 
    610                 615                 620                 
Pro Ile Gln Pro Phe Val Pro Gln Gly Phe Gln Glu Gln Gln Pro Pro 
625                 630                 635                 640 
Leu Ser Gln Val Phe Gln Gly Ile Ser Gln Leu Pro Gln Tyr Asn Asn 
                645                 650                 655     
Cys Pro Pro Pro Gln Ala Ala Val Gln Gln 
            660                 665     

<210> 24
<211> 588
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 24
Met Val Thr Pro Val Thr Trp Met Asp Asn Pro Ile Glu Val Tyr Val 
1               5                   10                  15      
Asn Asp Ser Glu Trp Val Pro Gly Pro Thr Asp Asp Arg Cys Pro Ala 
            20                  25                  30          
Lys Pro Glu Glu Glu Gly Met Met Ile Asn Ile Ser Ile Gly Tyr Arg 
        35                  40                  45              
Tyr Pro Pro Ile Cys Leu Gly Thr Ala Pro Gly Cys Leu Met Pro Ala 
    50                  55                  60                  
Val Gln Asn Trp Leu Val Glu Val Pro Ile Val Ser Pro Ile Ser Arg 
65                  70                  75                  80  
Phe Thr Tyr His Met Val Ser Gly Met Ser Leu Arg Pro Arg Val Asn 
                85                  90                  95      
Tyr Leu Gln Asp Phe Pro Tyr Gln Arg Ser Leu Lys Phe Arg Pro Lys 
            100                 105                 110         
Gly Lys Pro Cys Pro Lys Glu Ile Pro Lys Glu Ser Lys Asn Thr Glu 
        115                 120                 125             
Val Leu Val Trp Glu Glu Cys Val Ala Asn Ser Ala Val Ile Leu Gln 
    130                 135                 140                 
Asn Asn Glu Phe Gly Thr Ile Ile Asp Trp Ala Pro Arg Gly Gln Phe 
145                 150                 155                 160 
Tyr His Asn Cys Ser Gly Gln Thr Gln Ser Cys Pro Ser Ala Gln Val 
                165                 170                 175     
Ser Pro Ala Val Asp Ser Asp Leu Thr Glu Ser Leu Asp Lys His Lys 
            180                 185                 190         
His Lys Lys Leu Gln Ser Phe Tyr Pro Trp Glu Trp Gly Glu Lys Gly 
        195                 200                 205             
Ile Ser Thr Pro Arg Pro Lys Ile Ile Ser Pro Val Ser Gly Pro Glu 
    210                 215                 220                 
His Pro Glu Leu Trp Arg Leu Thr Val Ala Ser His His Ile Arg Ile 
225                 230                 235                 240 
Trp Ser Gly Asn Gln Thr Leu Glu Thr Arg Asp Arg Lys Pro Phe Tyr 
                245                 250                 255     
Thr Val Asp Leu Asn Ser Ser Leu Thr Leu Pro Leu Gln Ser Cys Val 
            260                 265                 270         
Lys Pro Pro Tyr Met Leu Val Val Gly Asn Ile Val Ile Lys Pro Asp 
        275                 280                 285             
Ser Gln Thr Ile Thr Cys Glu Asn Cys Arg Leu Leu Thr Cys Ile Asp 
    290                 295                 300                 
Ser Thr Phe Asn Trp Gln His Arg Ile Leu Leu Val Arg Ala Arg Glu 
305                 310                 315                 320 
Gly Val Trp Ile Leu Val Ser Met Asp Arg Pro Trp Glu Ala Ser Pro 
                325                 330                 335     
Ser Val His Ile Leu Thr Glu Val Leu Lys Gly Val Leu Asn Arg Ser 
            340                 345                 350         
Lys Arg Phe Ile Phe Thr Leu Ile Ala Val Ile Met Gly Leu Ile Ala 
        355                 360                 365             
Val Thr Ala Thr Gly Ala Val Ala Gly Val Ala Leu His Ser Ser Val 
    370                 375                 380                 
Gln Ser Val Asn Phe Val Asn Asp Trp Gln Lys Asn Ser Thr Arg Leu 
385                 390                 395                 400 
Trp Asn Ser Gln Ser Ser Ile Asp Gln Lys Leu Ala Asn Gln Ile Asn 
                405                 410                 415     
Asp Leu Arg Gln Thr Val Ile Trp Met Gly Asp Arg Leu Met Ser Leu 
            420                 425                 430         
Glu His Arg Phe Gln Leu Gln Cys Asp Trp Asn Thr Ser Asp Phe Cys 
        435                 440                 445             
Ile Thr Pro Gln Ile Tyr Asn Glu Ser Glu His His Trp Asp Met Val 
    450                 455                 460                 
Arg His His Leu Gln Gly Arg Glu Asp Asn Leu Thr Leu Asp Ile Ser 
465                 470                 475                 480 
Lys Leu Lys Glu Gln Ile Phe Glu Ala Ser Lys Ala His Leu Asn Leu 
                485                 490                 495     
Val Pro Gly Thr Glu Ala Ile Ala Gly Val Ala Asp Gly Leu Ala Asn 
            500                 505                 510         
Leu Asn Pro Val Thr Trp Val Lys Thr Ile Gly Ser Thr Thr Ile Ile 
        515                 520                 525             
Asn Leu Ile Leu Ile Leu Val Cys Leu Phe Cys Leu Leu Leu Val Cys 
    530                 535                 540                 
Arg Cys Thr Gln Gln Leu Arg Arg Asp Ser Asp His Arg Glu Arg Ala 
545                 550                 555                 560 
Met Met Thr Met Ala Val Leu Ser Lys Arg Lys Gly Gly Asn Val Gly 
                565                 570                 575     
Lys Ser Lys Arg Asp Gln Ile Val Thr Val Ser Val 
            580                 585             

<210> 25
<211> 666
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 25
Met Gly Gln Thr Lys Ser Lys Ile Lys Ser Lys Tyr Ala Ser Tyr Leu 
1               5                   10                  15      
Ser Phe Ile Lys Ile Leu Leu Lys Arg Gly Gly Val Lys Val Ser Thr 
            20                  25                  30          
Lys Asn Leu Ile Lys Leu Phe Gln Ile Ile Glu Gln Phe Cys Pro Trp 
        35                  40                  45              
Phe Pro Glu Gln Gly Thr Leu Asp Leu Lys Asp Trp Lys Arg Ile Gly 
    50                  55                  60                  
Lys Glu Leu Lys Gln Ala Gly Arg Lys Gly Asn Ile Ile Pro Leu Thr 
65                  70                  75                  80  
Val Trp Asn Asp Trp Ala Ile Ile Lys Ala Ala Leu Glu Pro Phe Gln 
                85                  90                  95      
Thr Glu Glu Asp Ser Val Ser Val Ser Asp Ala Pro Gly Ser Cys Leu 
            100                 105                 110         
Ile Asp Cys Asn Glu Lys Thr Arg Lys Lys Ser Gln Lys Glu Thr Glu 
        115                 120                 125             
Ser Leu His Cys Glu Tyr Val Ala Glu Pro Val Met Ala Gln Ser Thr 
    130                 135                 140                 
Gln Asn Val Asp Tyr Asn Gln Leu Gln Glu Val Ile Tyr Pro Glu Thr 
145                 150                 155                 160 
Leu Lys Leu Glu Gly Lys Gly Pro Glu Leu Val Gly Pro Ser Glu Ser 
                165                 170                 175     
Lys Pro Arg Gly Thr Ser Pro Leu Pro Ala Gly Gln Val Pro Val Thr 
            180                 185                 190         
Leu Gln Pro Gln Lys Gln Val Lys Glu Asn Lys Thr Gln Pro Pro Val 
        195                 200                 205             
Ala Tyr Gln Tyr Trp Pro Pro Ala Glu Leu Gln Tyr Arg Pro Pro Pro 
    210                 215                 220                 
Glu Ser Gln Tyr Gly Tyr Pro Gly Met Pro Pro Ala Pro Gln Gly Arg 
225                 230                 235                 240 
Ala Pro Tyr Pro Gln Pro Pro Thr Arg Arg Leu Asn Pro Thr Ala Pro 
                245                 250                 255     
Pro Ser Arg Gln Gly Ser Glu Leu His Glu Ile Ile Asp Lys Ser Arg 
            260                 265                 270         
Lys Glu Gly Asp Thr Glu Ala Trp Gln Phe Pro Val Thr Leu Glu Pro 
        275                 280                 285             
Met Pro Pro Gly Glu Gly Ala Gln Glu Gly Glu Pro Pro Thr Val Glu 
    290                 295                 300                 
Ala Arg Tyr Lys Ser Phe Ser Ile Lys Met Leu Lys Asp Met Lys Glu 
305                 310                 315                 320 
Gly Val Lys Gln Tyr Gly Pro Asn Ser Pro Tyr Met Arg Thr Leu Leu 
                325                 330                 335     
Asp Ser Ile Ala Tyr Gly His Arg Leu Ile Pro Tyr Asp Trp Glu Ile 
            340                 345                 350         
Leu Ala Lys Ser Ser Leu Ser Pro Ser Gln Phe Leu Gln Phe Lys Thr 
        355                 360                 365             
Trp Trp Ile Asp Gly Val Gln Glu Gln Val Arg Arg Asn Arg Ala Ala 
    370                 375                 380                 
Asn Pro Pro Val Asn Ile Asp Ala Asp Gln Leu Leu Gly Ile Gly Gln 
385                 390                 395                 400 
Asn Trp Ser Thr Ile Ser Gln Gln Ala Leu Met Gln Asn Glu Ala Ile 
                405                 410                 415     
Glu Gln Val Arg Ala Ile Cys Leu Arg Ala Trp Glu Lys Ile Gln Asp 
            420                 425                 430         
Pro Gly Ser Ala Cys Pro Ser Phe Asn Thr Val Arg Gln Gly Ser Lys 
        435                 440                 445             
Glu Pro Tyr Pro Asp Phe Val Ala Arg Leu Gln Asp Val Ala Gln Lys 
    450                 455                 460                 
Ser Ile Ala Asp Glu Lys Ala Arg Lys Val Ile Val Glu Leu Met Ala 
465                 470                 475                 480 
Tyr Glu Asn Ala Asn Pro Glu Cys Gln Ser Ala Ile Lys Pro Leu Lys 
                485                 490                 495     
Gly Lys Val Pro Ala Gly Ser Asp Val Ile Ser Glu Tyr Val Lys Ala 
            500                 505                 510         
Cys Asp Gly Ile Gly Gly Ala Met His Lys Ala Met Leu Met Ala Gln 
        515                 520                 525             
Ala Ile Thr Gly Val Val Leu Gly Gly Gln Val Arg Thr Phe Gly Gly 
    530                 535                 540                 
Lys Cys Tyr Asn Cys Gly Gln Ile Gly His Leu Lys Lys Asn Cys Pro 
545                 550                 555                 560 
Val Leu Asn Lys Gln Asn Ile Thr Ile Gln Ala Thr Thr Thr Gly Arg 
                565                 570                 575     
Glu Pro Pro Asp Leu Cys Pro Arg Cys Lys Lys Gly Lys His Trp Ala 
            580                 585                 590         
Ser Gln Cys Arg Ser Lys Phe Asp Lys Asn Gly Gln Pro Leu Ser Gly 
        595                 600                 605             
Asn Glu Gln Arg Gly Gln Pro Gln Ala Pro Gln Gln Thr Gly Ala Phe 
    610                 615                 620                 
Pro Ile Gln Pro Phe Val Pro Gln Gly Phe Gln Gly Gln Gln Pro Pro 
625                 630                 635                 640 
Leu Ser Gln Val Phe Gln Gly Ile Ser Gln Leu Pro Gln Tyr Asn Asn 
                645                 650                 655     
Cys Pro Leu Pro Gln Ala Ala Val Gln Gln 
            660                 665     

<210> 26
<211> 560
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 26
Met Val Thr Pro Val Thr Trp Met Asp Asn Pro Ile Glu Val Tyr Val 
1               5                   10                  15      
Asn Asp Ser Val Trp Val Pro Gly Pro Thr Asp Asp Arg Cys Pro Ala 
            20                  25                  30          
Lys Pro Glu Glu Glu Gly Met Met Ile Asn Ile Ser Ile Gly Tyr His 
        35                  40                  45              
Tyr Pro Pro Ile Cys Leu Gly Arg Ala Pro Gly Cys Leu Met Pro Ala 
    50                  55                  60                  
Val Gln Asn Trp Leu Val Glu Val Pro Thr Val Ser Pro Asn Ser Arg 
65                  70                  75                  80  
Phe Thr Tyr His Met Val Ser Gly Met Ser Leu Arg Pro Arg Val Asn 
                85                  90                  95      
Cys Leu Gln Asp Phe Ser Tyr Gln Arg Ser Leu Lys Phe Arg Pro Lys 
            100                 105                 110         
Gly Lys Thr Cys Pro Lys Glu Ile Pro Lys Gly Ser Lys Asn Thr Glu 
        115                 120                 125             
Val Leu Val Trp Glu Glu Cys Val Ala Asn Ser Val Val Ile Leu Gln 
    130                 135                 140                 
Asn Asn Glu Phe Gly Thr Ile Ile Asp Trp Ala Pro Arg Gly Gln Phe 
145                 150                 155                 160 
Tyr His Asn Cys Ser Gly Gln Thr Gln Ser Cys Pro Ser Ala Gln Val 
                165                 170                 175     
Ser Pro Ala Val Asp Ser Asp Leu Thr Glu Ser Leu Asp Lys His Lys 
            180                 185                 190         
His Lys Lys Leu Gln Ser Phe Tyr Leu Trp Glu Trp Glu Glu Lys Gly 
        195                 200                 205             
Ile Ser Thr Pro Arg Pro Lys Ile Ile Ser Pro Val Ser Gly Pro Glu 
    210                 215                 220                 
His Pro Glu Leu Trp Arg Leu Thr Val Ala Ser His His Ile Arg Ile 
225                 230                 235                 240 
Trp Ser Gly Asn Gln Thr Leu Glu Thr Arg Tyr Arg Lys Pro Phe Tyr 
                245                 250                 255     
Thr Ile Asp Leu Asn Ser Ile Leu Thr Val Pro Leu Gln Ser Cys Val 
            260                 265                 270         
Lys Pro Pro Tyr Met Leu Val Val Gly Asn Ile Val Ile Lys Pro Ala 
        275                 280                 285             
Ser Gln Thr Ile Thr Cys Glu Asn Cys Arg Leu Phe Thr Cys Ile Asp 
    290                 295                 300                 
Ser Thr Phe Asn Trp Gln His Arg Ile Leu Leu Val Arg Ala Arg Glu 
305                 310                 315                 320 
Gly Met Trp Ile Pro Val Ser Thr Asp Arg Pro Trp Glu Ala Ser Pro 
                325                 330                 335     
Ser Ile His Ile Leu Thr Glu Ile Leu Lys Gly Val Leu Asn Arg Ser 
            340                 345                 350         
Lys Arg Phe Ile Phe Thr Leu Ile Ala Val Ile Met Gly Leu Ile Ala 
        355                 360                 365             
Val Thr Ala Thr Ala Ala Val Ala Gly Val Ala Leu His Ser Ser Val 
    370                 375                 380                 
Gln Ser Val Asn Phe Val Asn Tyr Trp Gln Lys Asn Ser Thr Arg Leu 
385                 390                 395                 400 
Trp Asn Ser Gln Ser Ser Ile Asp Gln Lys Leu Ala Ser Gln Ile Asn 
                405                 410                 415     
Asp Leu Arg Gln Thr Val Ile Trp Met Gly Asp Arg Leu Met Thr Leu 
            420                 425                 430         
Glu His His Phe Gln Leu Gln Cys Asp Trp Asn Thr Ser Asp Phe Cys 
        435                 440                 445             
Ile Thr Pro Gln Ile Tyr Asn Glu Ser Glu His His Trp Asp Met Val 
    450                 455                 460                 
Arg Arg His Leu Gln Gly Arg Glu Asp Asn Leu Thr Leu Asp Ile Ser 
465                 470                 475                 480 
Lys Leu Lys Glu Gln Ile Phe Glu Ala Ser Lys Ala His Leu Asn Leu 
                485                 490                 495     
Val Pro Gly Thr Glu Ala Ile Ala Gly Val Ala Asp Gly Leu Ala Asn 
            500                 505                 510         
Leu Asn Pro Val Thr Trp Ile Lys Thr Ile Arg Ser Thr Met Ile Ile 
        515                 520                 525             
Asn Leu Ile Leu Ile Val Val Cys Leu Phe Cys Leu Leu Leu Val Cys 
    530                 535                 540                 
Arg Cys Thr Gln Gln Leu Arg Arg Asp Ser Asp Ile Glu Asn Gly Pro 
545                 550                 555                 560 



<210> 27
<211> 584
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 27
Met Ile Phe Ala Gly Lys Ala Pro Ser Asn Thr Ser Thr Leu Met Lys 
1               5                   10                  15      
Phe Tyr Ser Leu Leu Leu Tyr Ser Leu Leu Phe Ser Phe Pro Phe Leu 
            20                  25                  30          
Cys His Pro Leu Pro Leu Pro Ser Tyr Leu His His Thr Ile Asn Leu 
        35                  40                  45              
Thr His Ser Leu Leu Ala Ala Ser Asn Pro Ser Leu Val Asn Asn Cys 
    50                  55                  60                  
Trp Leu Cys Ile Ser Leu Ser Ser Ser Ala Tyr Thr Ala Val Pro Ala 
65                  70                  75                  80  
Val Gln Thr Asp Trp Ala Thr Ser Pro Ile Ser Leu His Leu Arg Thr 
                85                  90                  95      
Ser Phe Asn Ser Pro His Leu Tyr Pro Pro Glu Glu Leu Ile Tyr Phe 
            100                 105                 110         
Leu Asp Arg Ser Ser Lys Thr Ser Pro Asp Ile Ser His Gln Gln Ala 
        115                 120                 125             
Ala Ala Leu Leu Arg Thr Tyr Leu Lys Asn Leu Ser Pro Tyr Ile Asn 
    130                 135                 140                 
Ser Thr Pro Pro Ile Phe Gly Pro Leu Thr Thr Gln Thr Thr Ile Pro 
145                 150                 155                 160 
Val Ala Ala Pro Leu Cys Ile Ser Trp Gln Arg Pro Thr Gly Ile Pro 
                165                 170                 175     
Leu Gly Asn Leu Ser Pro Ser Arg Cys Ser Phe Thr Leu His Leu Arg 
            180                 185                 190         
Ser Pro Thr Thr Asn Ile Asn Glu Thr Ile Gly Ala Phe Gln Leu His 
        195                 200                 205             
Ile Thr Asp Lys Pro Ser Ile Asn Thr Asp Lys Leu Lys Asn Ile Ser 
    210                 215                 220                 
Ser Asn Tyr Cys Leu Gly Arg His Leu Pro Cys Ile Ser Leu His Pro 
225                 230                 235                 240 
Trp Leu Ser Ser Pro Cys Ser Ser Asp Ser Pro Pro Arg Pro Ser Ser 
                245                 250                 255     
Cys Leu Leu Ile Pro Ser Pro Glu Asn Asn Ser Glu Arg Leu Leu Val 
            260                 265                 270         
Asp Thr Arg Arg Phe Leu Ile His His Glu Asn Arg Thr Phe Pro Ser 
        275                 280                 285             
Thr Gln Leu Pro His Gln Ser Pro Leu Gln Pro Leu Thr Ala Ala Ala 
    290                 295                 300                 
Leu Ala Gly Ser Leu Gly Val Trp Val Gln Asp Thr Pro Phe Ser Thr 
305                 310                 315                 320 
Pro Ser His Leu Phe Thr Leu His Leu Gln Phe Cys Leu Ala Gln Gly 
                325                 330                 335     
Leu Phe Phe Leu Cys Gly Ser Ser Thr Tyr Met Cys Leu Pro Ala Asn 
            340                 345                 350         
Trp Thr Gly Thr Cys Thr Leu Val Phe Leu Thr Pro Lys Ile Gln Phe 
        355                 360                 365             
Ala Asn Gly Thr Glu Glu Leu Pro Val Pro Leu Met Thr Pro Thr Gln 
    370                 375                 380                 
Gln Lys Arg Val Ile Pro Leu Ile Pro Leu Met Val Gly Leu Gly Leu 
385                 390                 395                 400 
Ser Ala Ser Thr Val Ala Leu Gly Thr Gly Ile Ala Gly Ile Ser Thr 
                405                 410                 415     
Ser Val Met Thr Phe Arg Ser Leu Ser Asn Asp Phe Ser Ala Ser Ile 
            420                 425                 430         
Thr Asp Ile Ser Gln Thr Leu Ser Val Leu Gln Ala Gln Val Asp Ser 
        435                 440                 445             
Leu Ala Ala Val Val Leu Gln Asn Arg Arg Gly Leu Asp Leu Leu Thr 
    450                 455                 460                 
Ala Glu Lys Gly Gly Leu Cys Ile Phe Leu Asn Glu Glu Cys Cys Phe 
465                 470                 475                 480 
Tyr Leu Asn Gln Ser Gly Leu Val Tyr Asp Asn Ile Lys Lys Leu Lys 
                485                 490                 495     
Asp Arg Ala Gln Lys Leu Ala Asn Gln Ala Ser Asn Tyr Ala Glu Pro 
            500                 505                 510         
Pro Trp Ala Leu Ser Asn Trp Met Ser Trp Val Leu Pro Ile Val Ser 
        515                 520                 525             
Pro Leu Ile Pro Ile Phe Leu Leu Leu Leu Phe Gly Pro Cys Ile Phe 
    530                 535                 540                 
Arg Leu Val Ser Gln Phe Ile Gln Asn Arg Ile Gln Ala Ile Thr Asn 
545                 550                 555                 560 
His Ser Ile Arg Gln Met Phe Leu Leu Thr Ser Pro Gln Tyr His Pro 
                565                 570                 575     
Leu Pro Gln Asp Leu Pro Ser Ala 
            580                 

<210> 28
<211> 555
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 28
Met Ile Leu Ala Gly Arg Ala Pro Ser Asn Thr Ser Thr Leu Met Lys 
1               5                   10                  15      
Phe Tyr Ser Leu Leu Leu Tyr Ser Leu Leu Phe Ser Phe Pro Phe Leu 
            20                  25                  30          
Tyr His Pro Leu Pro Leu Pro Ser Tyr Leu His His Thr Ile Asn Leu 
        35                  40                  45              
Thr His Ser Leu Pro Ala Ala Ser Asn Pro Ser Leu Ala Asn Asn Cys 
    50                  55                  60                  
Trp Leu Cys Ile Ser Leu Ser Ser Ser Ala Tyr Ile Ala Val Pro Thr 
65                  70                  75                  80  
Leu Gln Thr Asp Arg Ala Thr Ser Pro Val Ser Leu His Leu Arg Thr 
                85                  90                  95      
Ser Phe Asn Ser Pro His Leu Tyr Pro Pro Glu Glu Leu Ile Tyr Phe 
            100                 105                 110         
Leu Asp Arg Ser Ser Lys Thr Ser Pro Asp Ile Ser His Gln Pro Ala 
        115                 120                 125             
Ala Ala Leu Leu His Ile Tyr Leu Lys Asn Leu Ser Pro Tyr Ile Asn 
    130                 135                 140                 
Ser Thr Pro Pro Ile Phe Gly Pro Leu Thr Thr Gln Thr Thr Ile Pro 
145                 150                 155                 160 
Val Ala Ala Pro Leu Cys Ile Ser Arg Gln Arg Pro Thr Gly Ile Pro 
                165                 170                 175     
Leu Gly Asn Ile Ser Pro Ser Arg Cys Ser Phe Thr Leu His Leu Gln 
            180                 185                 190         
Ser Pro Thr Thr His Val Thr Glu Thr Ile Gly Val Phe Gln Leu His 
        195                 200                 205             
Ile Ile Asp Lys Pro Ser Ile Asn Thr Asp Lys Leu Lys Asn Val Ser 
    210                 215                 220                 
Ser Asn Tyr Cys Leu Gly Arg His Leu Pro Tyr Ile Ser Leu His Pro 
225                 230                 235                 240 
Trp Leu Pro Ser Pro Cys Ser Ser Asp Ser Pro Pro Arg Pro Ser Ser 
                245                 250                 255     
Cys Leu Leu Thr Pro Ser Pro Gln Asn Asn Ser Glu Arg Leu Leu Val 
            260                 265                 270         
Asp Thr Gln Arg Phe Leu Ile His His Glu Asn Arg Thr Ser Ser Ser 
        275                 280                 285             
Met Gln Leu Ala His Gln Ser Pro Leu Gln Pro Leu Thr Ala Ala Ala 
    290                 295                 300                 
Leu Ala Gly Ser Leu Gly Val Trp Val Gln Asp Thr Pro Phe Ser Thr 
305                 310                 315                 320 
Pro Ser His Pro Phe Ser Leu His Leu Gln Phe Cys Leu Thr Gln Gly 
                325                 330                 335     
Leu Phe Phe Leu Cys Gly Ser Ser Thr Tyr Met Cys Leu Pro Ala Asn 
            340                 345                 350         
Trp Thr Gly Thr Cys Thr Leu Val Phe Leu Thr Pro Lys Ile Gln Phe 
        355                 360                 365             
Ala Asn Gly Thr Lys Glu Leu Pro Val Pro Leu Met Thr Leu Thr Pro 
    370                 375                 380                 
Gln Lys Arg Val Ile Pro Leu Ile Pro Leu Met Val Gly Leu Gly Leu 
385                 390                 395                 400 
Ser Ala Ser Thr Ile Ala Leu Ser Thr Gly Ile Ala Gly Ile Ser Thr 
                405                 410                 415     
Ser Val Thr Thr Phe Arg Ser Pro Ser Asn Asp Phe Ser Ala Ser Ile 
            420                 425                 430         
Thr Asp Ile Ser Gln Thr Leu Ser Val Leu Gln Ala Gln Val Asp Ser 
        435                 440                 445             
Leu Ala Ala Val Val Leu Gln Asn Arg Arg Gly Leu Gly Leu Ser Ile 
    450                 455                 460                 
Leu Leu Asn Glu Glu Cys Cys Phe Tyr Leu Asn Gln Ser Gly Leu Val 
465                 470                 475                 480 
Tyr Glu Asn Ile Lys Lys Leu Lys Asp Arg Ala Gln Lys Leu Ala Asn 
                485                 490                 495     
Gln Ala Ser Asn Tyr Ala Glu Ser Pro Trp Ala Leu Ser Asn Trp Met 
            500                 505                 510         
Ser Trp Val Leu Pro Ile Leu Ser Pro Leu Ile Pro Ile Phe Leu Leu 
        515                 520                 525             
Leu Leu Phe Gly Pro Cys Ile Phe His Leu Val Ser Gln Phe Ile Gln 
    530                 535                 540                 
Asn Arg Ile Gln Ala Ile Thr Asn His Ser Ile 
545                 550                 555 

<210> 29
<211> 215
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 29
Met Gly Asn Leu Pro Pro Ser Ile Pro Pro Ser Ser Pro Leu Ala Cys 
1               5                   10                  15      
Val Leu Lys Asn Leu Lys Pro Leu Gln Leu Thr Pro Asp Leu Lys Pro 
            20                  25                  30          
Lys Cys Leu Ile Phe Phe Cys Asn Thr Ala Trp Pro Gln Tyr Lys Leu 
        35                  40                  45              
Asp Asn Gly Ser Lys Trp Pro Glu Asn Gly Thr Phe Asp Phe Ser Ile 
    50                  55                  60                  
Leu Gln Asp Leu Asn Asn Phe Cys Arg Lys Met Gly Lys Trp Ser Glu 
65                  70                  75                  80  
Val Pro Tyr Val Gln Ala Phe Phe Thr Leu Arg Ser Leu Pro Ser Leu 
                85                  90                  95      
Cys Ser Gln Cys Asp Ala Ser Gln Ile Leu Leu Leu Ser Leu Pro Pro 
            100                 105                 110         
Val Pro Ser Val Pro Thr Pro Ser Val Ala Glu Ser Phe Arg Ser Ser 
        115                 120                 125             
Phe Ser Thr Asp Pro Ser Asp Leu Ser Pro Pro Pro Gln Ala Ala Arg 
    130                 135                 140                 
Arg Gln Ala Glu Leu Gly Pro Asn Ser Ser Ser Ala Ser Ala Pro Pro 
145                 150                 155                 160 
Pro Tyr Asn Leu Phe Ile Ala Ser Pro Pro His Thr Trp Ser Gly Leu 
                165                 170                 175     
Gln Phe His Ser Met Thr Ser Leu Pro Pro Pro Ala Gln Gln Phe Thr 
            180                 185                 190         
Leu Lys Lys Val Ala Gly Ala Lys Gly Ile Val Lys Val Asn Ala Pro 
        195                 200                 205             
Phe Ser Leu Ser Gln Ile Arg 
    210                 215 

<210> 30
<211> 538
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 30
Met Ala Leu Pro Tyr His Ile Phe Leu Phe Thr Val Leu Leu Pro Ser 
1               5                   10                  15      
Phe Thr Leu Thr Ala Pro Pro Pro Cys Arg Cys Met Thr Ser Ser Ser 
            20                  25                  30          
Pro Tyr Gln Glu Phe Leu Trp Arg Met Gln Arg Pro Gly Asn Ile Asp 
        35                  40                  45              
Ala Pro Ser Tyr Arg Ser Leu Ser Lys Gly Thr Pro Thr Phe Thr Ala 
    50                  55                  60                  
His Thr His Met Pro Arg Asn Cys Tyr His Ser Ala Thr Leu Cys Met 
65                  70                  75                  80  
His Ala Asn Thr His Tyr Trp Thr Gly Lys Met Ile Asn Pro Ser Cys 
                85                  90                  95      
Pro Gly Gly Leu Gly Val Thr Val Cys Trp Thr Tyr Phe Thr Gln Thr 
            100                 105                 110         
Gly Met Ser Asp Gly Gly Gly Val Gln Asp Gln Ala Arg Glu Lys His 
        115                 120                 125             
Val Lys Glu Val Ile Ser Gln Leu Thr Arg Val His Gly Thr Ser Ser 
    130                 135                 140                 
Pro Tyr Lys Gly Leu Asp Leu Ser Lys Leu His Glu Thr Leu Arg Thr 
145                 150                 155                 160 
His Thr Arg Leu Val Ser Leu Phe Asn Thr Thr Leu Thr Gly Leu His 
                165                 170                 175     
Glu Val Ser Ala Gln Asn Pro Thr Asn Cys Trp Ile Cys Leu Pro Leu 
            180                 185                 190         
Asn Phe Arg Pro Tyr Val Ser Ile Pro Val Pro Glu Gln Trp Asn Asn 
        195                 200                 205             
Phe Ser Thr Glu Ile Asn Thr Thr Ser Val Leu Val Gly Pro Leu Val 
    210                 215                 220                 
Ser Asn Leu Glu Ile Thr His Thr Ser Asn Leu Thr Cys Val Lys Phe 
225                 230                 235                 240 
Ser Asn Thr Thr Tyr Thr Thr Asn Ser Gln Cys Ile Arg Trp Val Thr 
                245                 250                 255     
Pro Pro Thr Gln Ile Val Cys Leu Pro Ser Gly Ile Phe Phe Val Cys 
            260                 265                 270         
Gly Thr Ser Ala Tyr Arg Cys Leu Asn Gly Ser Ser Glu Ser Met Cys 
        275                 280                 285             
Phe Leu Ser Phe Leu Val Pro Pro Met Thr Ile Tyr Thr Glu Gln Asp 
    290                 295                 300                 
Leu Tyr Ser Tyr Val Ile Ser Lys Pro Arg Asn Lys Arg Val Pro Ile 
305                 310                 315                 320 
Leu Pro Phe Val Ile Gly Ala Gly Val Leu Gly Ala Leu Gly Thr Gly 
                325                 330                 335     
Ile Gly Gly Ile Thr Thr Ser Thr Gln Phe Tyr Tyr Lys Leu Ser Gln 
            340                 345                 350         
Glu Leu Asn Gly Asp Met Glu Arg Val Ala Asp Ser Leu Val Thr Leu 
        355                 360                 365             
Gln Asp Gln Leu Asn Ser Leu Ala Ala Val Val Leu Gln Asn Arg Arg 
    370                 375                 380                 
Ala Leu Asp Leu Leu Thr Ala Glu Arg Gly Gly Thr Cys Leu Phe Leu 
385                 390                 395                 400 
Gly Glu Glu Cys Cys Tyr Tyr Val Asn Gln Ser Gly Ile Val Thr Glu 
                405                 410                 415     
Lys Val Lys Glu Ile Arg Asp Arg Ile Gln Arg Arg Ala Glu Glu Leu 
            420                 425                 430         
Arg Asn Thr Gly Pro Trp Gly Leu Leu Ser Gln Trp Met Pro Trp Ile 
        435                 440                 445             
Leu Pro Phe Leu Gly Pro Leu Ala Ala Ile Ile Leu Leu Leu Leu Phe 
    450                 455                 460                 
Gly Pro Cys Ile Phe Asn Leu Leu Val Asn Phe Val Ser Ser Arg Ile 
465                 470                 475                 480 
Glu Ala Val Lys Leu Gln Met Glu Pro Lys Met Gln Ser Lys Thr Lys 
                485                 490                 495     
Ile Tyr Arg Arg Pro Leu Asp Arg Pro Ala Ser Pro Arg Ser Asp Val 
            500                 505                 510         
Asn Asp Ile Lys Gly Thr Pro Pro Glu Glu Ile Ser Ala Ala Gln Pro 
        515                 520                 525             
Leu Leu Arg Pro Asn Ser Ala Gly Ser Ser 
    530                 535             

<210> 31
<211> 538
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 31
Met Gly Leu Leu Leu Leu Val Leu Ile Leu Thr Pro Ser Leu Ala Ala 
1               5                   10                  15      
Tyr Arg His Pro Asp Phe Pro Leu Leu Glu Lys Ala Gln Gln Leu Leu 
            20                  25                  30          
Gln Ser Thr Gly Ser Pro Tyr Ser Thr Asn Cys Trp Leu Cys Thr Ser 
        35                  40                  45              
Ser Ser Thr Glu Thr Pro Gly Thr Ala Tyr Pro Ala Ser Pro Arg Glu 
    50                  55                  60                  
Trp Thr Ser Ile Glu Ala Glu Leu His Ile Ser Tyr Arg Trp Asp Pro 
65                  70                  75                  80  
Asn Leu Lys Gly Leu Met Arg Pro Ala Asn Ser Leu Leu Ser Thr Val 
                85                  90                  95      
Lys Gln Asp Phe Pro Asp Ile Arg Gln Lys Pro Pro Ile Phe Gly Pro 
            100                 105                 110         
Ile Phe Thr Asn Ile Asn Leu Met Gly Ile Ala Pro Ile Cys Val Met 
        115                 120                 125             
Ala Lys Arg Lys Asn Gly Thr Asn Val Gly Thr Leu Pro Ser Thr Val 
    130                 135                 140                 
Cys Asn Val Thr Phe Thr Val Asp Ser Asn Gln Gln Thr Tyr Gln Thr 
145                 150                 155                 160 
Tyr Thr His Asn Gln Phe Arg His Gln Pro Arg Phe Pro Lys Pro Pro 
                165                 170                 175     
Asn Ile Thr Phe Pro Gln Gly Thr Leu Leu Asp Lys Ser Ser Arg Phe 
            180                 185                 190         
Cys Gln Gly Arg Pro Ser Ser Cys Ser Thr Arg Asn Phe Trp Phe Arg 
        195                 200                 205             
Pro Ala Asp Tyr Asn Gln Cys Leu Gln Ile Ser Asn Leu Ser Ser Thr 
    210                 215                 220                 
Ala Glu Trp Val Leu Leu Asp Gln Thr Arg Asn Ser Leu Phe Trp Glu 
225                 230                 235                 240 
Asn Lys Thr Lys Gly Ala Asn Gln Ser Gln Thr Pro Cys Val Gln Val 
                245                 250                 255     
Leu Ala Gly Met Thr Ile Ala Thr Ser Tyr Leu Gly Ile Ser Ala Val 
            260                 265                 270         
Ser Glu Phe Phe Gly Thr Ser Leu Thr Pro Leu Phe His Phe His Ile 
        275                 280                 285             
Ser Thr Cys Leu Lys Thr Gln Gly Ala Phe Tyr Ile Cys Gly Gln Ser 
    290                 295                 300                 
Ile His Gln Cys Leu Pro Ser Asn Trp Thr Gly Thr Cys Thr Ile Gly 
305                 310                 315                 320 
Tyr Val Thr Pro Asp Ile Phe Ile Ala Pro Gly Asn Leu Ser Leu Pro 
                325                 330                 335     
Ile Pro Ile Tyr Gly Asn Ser Pro Leu Pro Arg Val Arg Arg Ala Ile 
            340                 345                 350         
His Phe Ile Pro Leu Leu Ala Gly Leu Gly Ile Leu Ala Gly Thr Gly 
        355                 360                 365             
Thr Gly Ile Ala Gly Ile Thr Lys Ala Ser Leu Thr Tyr Ser Gln Leu 
    370                 375                 380                 
Ser Lys Glu Ile Ala Asn Asn Ile Asp Thr Met Ala Lys Ala Leu Thr 
385                 390                 395                 400 
Thr Met Gln Glu Gln Ile Asp Ser Leu Ala Ala Val Val Leu Gln Asn 
                405                 410                 415     
Arg Arg Gly Leu Asp Met Leu Thr Ala Ala Gln Gly Gly Ile Cys Leu 
            420                 425                 430         
Ala Leu Asp Glu Lys Cys Cys Phe Trp Val Asn Gln Ser Gly Lys Val 
        435                 440                 445             
Gln Asp Asn Ile Arg Gln Leu Leu Asn Gln Ala Ser Ser Leu Arg Glu 
    450                 455                 460                 
Arg Ala Thr Gln Gly Trp Leu Asn Trp Glu Gly Thr Trp Lys Trp Phe 
465                 470                 475                 480 
Ser Trp Val Leu Pro Leu Thr Gly Pro Leu Val Ser Leu Leu Leu Leu 
                485                 490                 495     
Leu Leu Phe Gly Pro Cys Leu Leu Asn Leu Ile Thr Gln Phe Val Ser 
            500                 505                 510         
Ser Arg Leu Gln Ala Ile Lys Leu Gln Thr Asn Leu Ser Ala Gly Arg 
        515                 520                 525             
His Pro Arg Asn Ile Gln Glu Ser Pro Phe 
    530                 535             

<210> 32
<211> 428
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 32
Met Gln Lys Leu Ile Met Gly Phe Ile Phe Leu Lys Phe Trp Thr Tyr 
1               5                   10                  15      
Thr Val Arg Ala Ser Thr Asp Leu Thr Gln Thr Gly Asp Cys Ser Gln 
            20                  25                  30          
Cys Ile His Gln Val Thr Glu Val Gly Gln Gln Ile Lys Thr Met Phe 
        35                  40                  45              
Leu Phe Tyr Ser Tyr Tyr Lys Cys Ile Gly Thr Leu Lys Glu Thr Cys 
    50                  55                  60                  
Leu Tyr Asn Ala Thr Gln Tyr Asn Val Cys Ser Pro Gly Asn Asp Arg 
65                  70                  75                  80  
Pro Asp Val Cys Tyr Asn Pro Ser Glu Pro Pro Ala Thr Thr Ile Phe 
                85                  90                  95      
Glu Ile Arg Ile Arg Thr Gly Leu Phe Leu Gly Asp Thr Ser Lys Ile 
            100                 105                 110         
Ile Thr Arg Thr Glu Glu Lys Glu Ile Pro Lys Gln Ile Thr Leu Arg 
        115                 120                 125             
Phe Asp Ala Cys Ala Ala Ile Asn Ser Lys Lys Leu Gly Ile Gly Cys 
    130                 135                 140                 
Asp Ser Leu Asn Trp Glu Arg Ser Tyr Arg Ile Lys Asn Lys Tyr Val 
145                 150                 155                 160 
Cys His Glu Ser Gly Val Cys Glu Asn Cys Ala Tyr Trp Pro Cys Val 
                165                 170                 175     
Ile Trp Ala Thr Trp Lys Lys Asn Lys Lys Asp Pro Val Tyr Leu Gln 
            180                 185                 190         
Lys Gly Glu Ala Asn Pro Ser Cys Ala Ala Gly His Cys Asn Pro Leu 
        195                 200                 205             
Glu Leu Ile Ile Thr Asn Pro Leu Asp Pro His Trp Lys Lys Gly Glu 
    210                 215                 220                 
Arg Val Thr Leu Gly Ile Asp Gly Thr Gly Leu Asn Pro Gln Val Ala 
225                 230                 235                 240 
Ile Leu Ile Arg Gly Glu Val His Lys Cys Ser Pro Lys Pro Val Phe 
                245                 250                 255     
Gln Thr Phe Tyr Lys Glu Leu Asn Leu Pro Ala Pro Glu Phe Pro Lys 
            260                 265                 270         
Lys Thr Lys Asn Leu Phe Leu Gln Leu Ala Glu Asn Val Ala His Ser 
        275                 280                 285             
Leu Asn Val Thr Ser Cys Tyr Val Cys Gly Gly Thr Thr Ile Gly Asp 
    290                 295                 300                 
Arg Trp Pro Trp Glu Ala Arg Glu Leu Val Pro Thr Asp Pro Ala Pro 
305                 310                 315                 320 
Asp Ile Ile Pro Val Gln Lys Thr Gln Ala Ser Asn Phe Trp Val Leu 
                325                 330                 335     
Lys Thr Ser Ile Ile Gly Gln Tyr Cys Ile Ala Arg Glu Gly Lys Asp 
            340                 345                 350         
Phe Ile Ile Pro Val Gly Lys Leu Asn Cys Ile Gly Gln Lys Leu Tyr 
        355                 360                 365             
Asn Ser Thr Thr Lys Thr Ile Thr Trp Trp Gly Ile Asn His Thr Glu 
    370                 375                 380                 
Lys Asn Pro Phe Ser Lys Phe Ser Lys Leu Lys Thr Ala Trp Ala His 
385                 390                 395                 400 
Pro Glu Ser His Gln Asp Trp Met Ala Pro Ala Gly Leu Tyr Trp Ile 
                405                 410                 415     
Cys Gly His Arg Ala Tyr Ile Arg Leu Pro Asn Lys 
            420                 425             

<210> 33
<211> 168
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 33
Met Leu Asn Arg Ile Ile Arg Leu Gln Ala Ile Leu Glu Ile Ile Thr 
1               5                   10                  15      
Asn Glu Thr Gly Arg Ala Leu Thr Val Leu Ala Arg Gln Glu Thr Gln 
            20                  25                  30          
Thr Arg Asn Ala Ile Tyr Gln Asn Arg Leu Ala Leu Asp Tyr Leu Leu 
        35                  40                  45              
Ala Ala Glu Gly Gly Val Cys Gly Lys Phe Asn Leu Thr Asn Tyr Cys 
    50                  55                  60                  
Leu Gln Ile Asp Asp Gln Gly Gln Val Val Glu Asn Ile Val Arg Asp 
65                  70                  75                  80  
Met Ala Lys Val Ala His Val Pro Val Gln Val Trp His Lys Phe Asn 
                85                  90                  95      
Pro Glu Ser Leu Phe Gly Lys Trp Phe Pro Ala Ile Gly Gly Phe Lys 
            100                 105                 110         
Thr Leu Ile Val Gly Val Leu Leu Val Ile Gly Thr Cys Leu Leu Leu 
        115                 120                 125             
Pro Cys Val Leu Pro Leu Leu Phe Gln Met Ile Lys Tyr Phe Val Val 
    130                 135                 140                 
Thr Leu Val His Gln Lys Thr Ser Ala His Val Tyr Tyr Thr Asn His 
145                 150                 155                 160 
Tyr Arg Ser Ile Ser Gln Arg Asp 
                165             

<210> 34
<211> 109
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 34
Pro Leu Gly Thr Met Leu Lys Asn Phe Lys Lys Gly Phe Asn Gly Asp 
1               5                   10                  15      
Tyr Gly Val Thr Met Thr Pro Gly Lys Leu Arg Thr Leu Cys Glu Ile 
            20                  25                  30          
Asp Trp Pro Thr Leu Glu Val Gly Trp Pro Ser Glu Gly Ser Leu Asp 
        35                  40                  45              
Gly Ser Leu Val Ser Lys Val Trp His Lys Val Thr Ser Lys Ser Gly 
    50                  55                  60                  
His Ser Asp Gln Phe Pro Tyr Ile Asp Thr Trp Leu Gln Leu Val Leu 
65                  70                  75                  80  
Asp Pro Pro Gln Trp Leu Arg Gly Gln Ala Ala Ala Val Leu Val Ala 
                85                  90                  95      
Lys Gly Gln Ile Val Lys Glu Gly Phe Cys Ser Thr Arg 
            100                 105                 

<210> 35
<211> 164
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 35
Gly Lys Ser Thr Pro Glu Val Leu Phe Asp Gln Thr Ser Glu Asp Pro 
1               5                   10                  15      
Leu Gln Glu Met Ala Pro Val Ile Pro Val Leu Pro Ser Pro Tyr Gln 
            20                  25                  30          
Gly Glu Arg Leu Pro Thr Phe Glu Ser Thr Val Leu Ala Pro Leu Pro 
        35                  40                  45              
Asp Lys Cys Ile Pro Arg Pro Leu Arg Val Asp Lys Arg Gly Gly Glu 
    50                  55                  60                  
Ala Ser Gly Glu Thr Pro Pro Leu Ala Ala His Leu Arg Pro Lys Thr 
65                  70                  75                  80  
Gly Ile Gln Met Pro Leu Arg Glu Gln Gln Tyr Thr Gly Ile Asp Glu 
                85                  90                  95      
Asp Gly His Met Val Glu Ser Arg Val Phe Val Tyr Gln Pro Phe Thr 
            100                 105                 110         
Ser Ala Asp Leu Leu Asn Trp Lys Asn Asn Thr Pro Ser Tyr Thr Glu 
        115                 120                 125             
Lys Pro Gln Ala Leu Ile Asp Leu Leu Gln Thr Ile Ile Gln Thr His 
    130                 135                 140                 
Asn Pro Thr Trp Ala Asp Cys His Gln Leu Leu Met Phe Leu Phe Lys 
145                 150                 155                 160 
Thr Asp Glu Arg 
                

<210> 36
<211> 39
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 36
Arg Val Leu Gln Ala Ala Thr Lys Trp Leu Glu Glu His Ala Leu Ala 
1               5                   10                  15      
Asp Tyr Gln Asn Pro Gln Glu Tyr Val Arg Thr Gln Leu Pro Gly Thr 
            20                  25                  30          
Asp Pro Gln Trp Asp Pro Asn 
        35                  

<210> 37
<211> 120
<212> PRT
<213> Homo sapiens


<220> 
<223> HERV-E Gag protein

<400> 37
Arg Glu Asp Met Gln Arg Leu Asn Arg Tyr Arg Lys Ala Leu Leu Glu 
1               5                   10                  15      
Gly Leu Lys Arg Arg Ala Gln Lys Ala Thr Asn Ile Asn Lys Val Ser 
            20                  25                  30          
Glu Val Ile Gln Gly Lys Glu Glu Ser Pro Ala Lys Phe His Glu Arg 
        35                  40                  45              
Leu Cys Glu Ala Tyr Cys Met Tyr Thr Pro Phe Asp Pro Asp Ser Pro 
    50                  55                  60                  
Glu Asn Gln Arg Met Ile Asn Met Ala Leu Val Ser Gln Ser Thr Glu 
65                  70                  75                  80  
Asp Ile Arg Arg Lys Leu Gln Lys Lys Ala Gly Phe Ala Gly Met Asn 
                85                  90                  95      
Thr Ser Gln Leu Leu Glu Ile Ala Asn Gln Val Phe Val Asn Arg Asp 
            100                 105                 110         
Ala Ala Ser Arg Lys Glu Thr Thr 
        115                 120 

<210> 38
<211> 90
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 38
Arg Met Asn Val Arg Pro Gly Glu Thr Arg Leu Leu Ala Ala Ala Ile 
1               5                   10                  15      
Arg Gly Val Pro Pro Lys Glu Ala Arg Gln Lys Gly Gly Pro Gly Lys 
            20                  25                  30          
Glu Thr Gln Pro Gly Cys Gln Ser Leu Gln Cys Asn Gln Cys Ala Tyr 
        35                  40                  45              
Arg Lys Glu Ile Gly Tyr Trp Lys Asn Lys Cys Pro Gln Leu Lys Gly 
    50                  55                  60                  
Lys Gln Gly Asp Ser Glu Gln Glu Ala Pro Asp Lys Glu Glu Gly Ala 
65                  70                  75                  80  
Leu Leu Asn Leu Ala Glu Gly Leu Leu Asp 
                85                  90  

<210> 39
<211> 682
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 39
Met Arg Lys Leu Ile Val Gly Phe Ile Phe Leu Thr Phe Trp Thr Tyr 
1               5                   10                  15      
Thr Val Arg Ala Ser Thr Asp Leu Thr Gln Thr Gly Asp Cys Ser Gln 
            20                  25                  30          
Ser Ile His Gln Val Thr Glu Val Gly Gln Gln Ile Lys Thr Asn Phe 
        35                  40                  45              
Leu Phe Tyr Ser Tyr Tyr Glu Cys Met Gly Thr Leu Lys Glu Thr Cys 
    50                  55                  60                  
Leu Tyr Asn Ala Thr Gln Tyr Lys Val Cys Ser Pro Gly Asn Asp Arg 
65                  70                  75                  80  
Pro Asp Val Cys Tyr Asn Pro Ser Glu Pro Pro Ala Thr Thr Val Phe 
                85                  90                  95      
Glu Ile Arg Leu Arg Thr Gly Leu Phe Leu Gly Asp Thr Ser Lys Ile 
            100                 105                 110         
Ile Thr Arg Thr Val Glu Lys Gly Ile Pro Lys Gln Ile Thr Leu Arg 
        115                 120                 125             
Phe Asp Ala Arg Ala Ala Ile Asn Ser Asn Lys Leu Gly Thr Arg Cys 
    130                 135                 140                 
Gly Ser Leu Asn Trp Glu Arg Ser Tyr Thr Val Gln Asn Lys Tyr Val 
145                 150                 155                 160 
Cys His Glu Ser Gly Val Cys Glu Asn Cys Ala Phe Trp Pro Cys Val 
                165                 170                 175     
Ile Trp Ala Thr Trp Lys Lys Asn Lys Lys Asp Pro Val His Leu Gln 
            180                 185                 190         
Lys Gly Glu Ala Asn Pro Ser Cys Ala Ala Gly His Cys Asn Pro Leu 
        195                 200                 205             
Glu Leu Ile Ile Thr Asn Pro Leu Asp Pro Pro Trp Lys Lys Gly Glu 
    210                 215                 220                 
Arg Val Thr Leu Gly Ile Asp Gly Thr Gly Leu Asn Pro Gln Val Ala 
225                 230                 235                 240 
Ile Leu Val Arg Gly Glu Val His Lys Arg Ser Pro Lys Pro Val Phe 
                245                 250                 255     
Gln Thr Phe Tyr Glu Glu Leu Asn Leu Pro Ala Pro Glu Leu Pro Lys 
            260                 265                 270         
Lys Thr Lys Ser Leu Phe Leu Gln Leu Ala Gly Asn Val Ala His Ser 
        275                 280                 285             
Leu Asn Val Thr Ser Cys Tyr Val Cys Arg Gly Thr Thr Ile Gly Asp 
    290                 295                 300                 
Arg Trp Pro Trp Glu Ala Arg Glu Leu Val Pro Thr Asp Pro Ala Pro 
305                 310                 315                 320 
Asp Ile Ile Pro Val Gln Lys Ala Gln Ala Ser Asn Phe Trp Val Leu 
                325                 330                 335     
Lys Thr Ser Ile Ile Gly Gln Tyr Cys Ile Ala Arg Glu Gly Lys Glu 
            340                 345                 350         
Phe Ile Val Pro Val Gly Lys Leu Asn Cys Ile Gly Gln Lys Leu Tyr 
        355                 360                 365             
Asn Ser Thr Thr Lys Thr Ile Thr Trp Trp Gly Leu Asn His Thr Glu 
    370                 375                 380                 
Lys Asn Pro Phe Ser Lys Phe Ser Lys Leu Lys Thr Ala Trp Ala His 
385                 390                 395                 400 
Pro Glu Ser His Gln Asp Trp Thr Ala Pro Thr Gly Leu Tyr Arg Ile 
                405                 410                 415     
Cys Gly His Thr Ala Tyr Ile Gln Leu Pro Asn Lys Trp Ala Gly Ser 
            420                 425                 430         
Cys Val Ile Gly Thr Ile Lys Leu Ser Phe Phe Leu Leu Pro Ile Lys 
        435                 440                 445             
Thr Gly Glu Leu Leu Gly Phe Arg Val Tyr Thr Ser Arg Glu Lys Arg 
    450                 455                 460                 
Gly Ile Val Ile Gly Asn Trp Lys Asp Asn Glu Trp Pro Pro Glu Arg 
465                 470                 475                 480 
Ile Ile Gln Tyr Tyr Gly Pro Ala Thr Trp Val Gln Asp Gly Ser Trp 
                485                 490                 495     
Gly Tyr Gln Thr Pro Ile Tyr Met Leu Asn Gln Ile Ile Arg Leu Gln 
            500                 505                 510         
Thr Val Leu Glu Ile Ile Thr Asn Glu Thr Gly Arg Ala Leu Thr Val 
        515                 520                 525             
Leu Ala Arg Gln Glu Thr Gln Met Arg Asn Ala Ile Tyr Gln Asn Arg 
    530                 535                 540                 
Leu Ala Leu Asp Tyr Leu Leu Ala Ala Glu Gly Gly Val Cys Gly Lys 
545                 550                 555                 560 
Phe Asn Leu Thr Asn Cys Cys Leu Gln Ile Asp Asp Gln Gly Gln Val 
                565                 570                 575     
Ile Glu Asn Ile Val Arg Asp Met Thr Lys Leu Ala His Thr Pro Ile 
            580                 585                 590         
Gln Val Trp His Lys Phe Asp Pro Glu Ser Leu Phe Gly Lys Trp Phe 
        595                 600                 605             
Pro Ala Ile Gly Gly Phe Lys Thr Leu Ile Val Gly Val Leu Leu Val 
    610                 615                 620                 
Ile Arg Thr Cys Leu Leu Leu Pro Cys Val Leu Pro Leu Leu Phe Gln 
625                 630                 635                 640 
Met Ile Lys Gly Ile Val Ala Thr Leu Val His Gln Lys Thr Ser Ala 
                645                 650                 655     
His Val Asn Tyr Met Asn His Tyr Arg Ser Ile Ser Gln Arg Asp Ser 
            660                 665                 670         
Lys Ser Glu Asp Glu Ser Glu Asn Ser His 
        675                 680         

<210> 40
<211> 523
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino acid sequence

<400> 40
Met Leu Lys Asn Phe Lys Lys Gly Phe Asn Gly Asp Tyr Gly Val Thr 
1               5                   10                  15      
Met Thr Pro Gly Lys Leu Arg Ile Leu Cys Glu Ile Asp Trp Pro Thr 
            20                  25                  30          
Leu Glu Val Gly Trp Pro Ser Glu Gly Ser Leu Asp Arg Ser Leu Val 
        35                  40                  45              
Ser Lys Val Trp His Lys Val Thr Gly Lys Ser Gly His Ser Asp Gln 
    50                  55                  60                  
Phe Pro Tyr Ile Asp Thr Trp Leu Leu Gln Leu Val Gln Asp Pro Pro 
65                  70                  75                  80  
Gln Trp Leu Arg Gly Gln Ala Ala Ala Val Leu Val Ala Lys Gly Gln 
                85                  90                  95      
Ile Ala Lys Glu Gly Ser Arg Ser Thr His Trp Gly Lys Ser Thr Pro 
            100                 105                 110         
Glu Val Leu Phe Asp Pro Thr Ser Glu Asp Pro Leu Gln Glu Met Ala 
        115                 120                 125             
Pro Val Ile Pro Val Leu Pro Ser Pro Tyr Gln Ala Glu Arg Leu Pro 
    130                 135                 140                 
Thr Phe Glu Pro Thr Val Leu Val Pro Pro Gln Asp Lys His Ile Pro 
145                 150                 155                 160 
Arg Pro Pro Arg Val Asp Lys Arg Gly Gly Glu Ala Ser Gly Glu Thr 
                165                 170                 175     
Pro Pro Leu Ala Ala Cys Leu Arg Pro Lys Thr Gly Ile Gln Met Pro 
            180                 185                 190         
Leu Arg Glu Gln Arg Tyr Thr Gly Ile Glu Glu Asp Gly His Met Val 
        195                 200                 205             
Glu Lys Arg Val Phe Val Tyr Gln Pro Phe Thr Ser Ala Asn Leu Leu 
    210                 215                 220                 
Asn Trp Lys Asn Asn Thr Leu Ser Tyr Thr Glu Lys Pro Gln Ala Leu 
225                 230                 235                 240 
Ile Asp Leu Leu Gln Thr Ile Ile Gln Thr His Asn Ser Thr Arg Ala 
                245                 250                 255     
Asp Cys His Gln Leu Leu Met Phe Leu Phe Asn Thr Asp Glu Arg Gln 
            260                 265                 270         
Arg Val Leu Gln Ala Ala Thr Lys Trp Val Gln Glu His Ala Pro Ala 
        275                 280                 285             
Asp Tyr Gln Asn Pro Gln Glu Cys Val Arg Thr Gln Leu Pro Gly Thr 
    290                 295                 300                 
Asp Pro Gln Trp Asp Pro Asn Glu Arg Glu Asp Met Gln Arg Leu Asn 
305                 310                 315                 320 
Arg Asp Arg Glu Ala Val Leu Glu Gly Leu Lys Arg Gly Ala Gln Lys 
                325                 330                 335     
Ala Thr Asn Val Asn Lys Val Ser Glu Val Ile Arg Gly Lys Glu Glu 
            340                 345                 350         
Ser Pro Ala Gln Phe Tyr Gln Arg Leu Cys Glu Gly Tyr Arg Met Tyr 
        355                 360                 365             
Thr Pro Phe Asp Pro Val Ser Pro Glu Asn Gln Arg Met Val Asn Met 
    370                 375                 380                 
Ala Leu Val Ser Gln Ser Ala Glu Asp Ile Arg Arg Lys Leu Gln Lys 
385                 390                 395                 400 
Gln Asp Gly Phe Ala Gly Thr Asn Thr Ser Gln Leu Leu Glu Val Ala 
                405                 410                 415     
Asn Gln Val Phe Val Asn Arg Asp Ala Val Ser Pro Lys Glu Asn Arg 
            420                 425                 430         
Arg Glu Asn Glu Arg Gln Ala Arg Arg Asn Ala Glu Leu Leu Ala Ala 
        435                 440                 445             
Ala Val Gly Gly Val Ser Ser Lys Arg Gln Gly Lys Gly Gly Pro Gly 
    450                 455                 460                 
Lys Glu Thr Gln Pro Gly Cys Gln Ser Leu Gln Cys Asn Gln Cys Ala 
465                 470                 475                 480 
Tyr Cys Lys Glu Ile Gly Tyr Trp Lys Asn Lys Cys Pro Gln Leu Lys 
                485                 490                 495     
Gly Lys Gln Gly Asp Leu Glu Gln Glu Val Pro Asp Lys Glu Glu Gly 
            500                 505                 510         
Ala Leu Leu Asn Leu Ala Glu Glu Leu Leu Asp 
        515                 520             

<210> 41
<211> 669
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 41
Met Glu Ser Thr Thr Leu Ser Lys Pro Phe Lys Asn Gln Val Asn Pro 
1               5                   10                  15      
Trp Gly Pro Leu Ile Val Leu Leu Ile Leu Gly Gly Val Asn Pro Val 
            20                  25                  30          
Ala Leu Gly Asn Ser Pro His Gln Val Phe Asn Leu Ser Trp Glu Val 
        35                  40                  45              
Thr Asn Gly Asp Arg Glu Thr Val Trp Ala Ile Thr Gly Asn His Pro 
    50                  55                  60                  
Leu Trp Thr Trp Trp Pro Asp Leu Thr Pro Asp Leu Cys Met Leu Ala 
65                  70                  75                  80  
Leu His Gly Pro Ser Tyr Trp Gly Leu Glu Tyr Arg Ala Pro Phe Ser 
                85                  90                  95      
Pro Pro Pro Gly Pro Pro Cys Cys Ser Gly Ser Ser Asp Ser Thr Ser 
            100                 105                 110         
Gly Cys Ser Arg Asp Cys Glu Glu Pro Leu Thr Ser Tyr Thr Pro Arg 
        115                 120                 125             
Cys Asn Thr Ala Trp Asn Arg Leu Lys Leu Ser Lys Val Thr His Ala 
    130                 135                 140                 
His Asn Glu Gly Phe Tyr Val Cys Pro Gly Pro His Arg Pro Arg Trp 
145                 150                 155                 160 
Ala Arg Ser Cys Gly Gly Pro Glu Ser Phe Tyr Cys Ala Ser Trp Gly 
                165                 170                 175     
Cys Glu Thr Thr Gly Arg Ala Ser Trp Lys Pro Ser Ser Ser Trp Asp 
            180                 185                 190         
Tyr Ile Thr Val Ser Asn Asn Leu Thr Ser Asp Gln Ala Thr Pro Val 
        195                 200                 205             
Cys Lys Gly Asn Lys Trp Cys Asn Ser Leu Thr Ile Arg Phe Thr Ser 
    210                 215                 220                 
Phe Gly Lys Gln Ala Thr Ser Trp Val Thr Gly His Trp Trp Gly Leu 
225                 230                 235                 240 
Arg Leu Tyr Val Ser Gly His Asp Pro Gly Leu Ile Phe Gly Ile Arg 
                245                 250                 255     
Leu Lys Ile Thr Asp Ser Gly Pro Arg Val Pro Ile Gly Pro Asn Pro 
            260                 265                 270         
Val Leu Ser Asp Arg Arg Pro Pro Ser Arg Pro Arg Pro Thr Arg Ser 
        275                 280                 285             
Pro Pro Pro Ser Asn Ser Thr Pro Thr Glu Thr Pro Leu Thr Leu Pro 
    290                 295                 300                 
Glu Pro Pro Pro Ala Gly Val Glu Asn Arg Leu Leu Asn Leu Val Lys 
305                 310                 315                 320 
Gly Ala Tyr Gln Ala Leu Asn Leu Thr Ser Pro Asp Lys Thr Gln Glu 
                325                 330                 335     
Cys Trp Leu Cys Leu Val Ser Gly Pro Pro Tyr Tyr Glu Gly Val Ala 
            340                 345                 350         
Val Leu Gly Thr Tyr Ser Asn His Thr Ser Ala Pro Ala Asn Cys Ser 
        355                 360                 365             
Val Ala Ser Gln His Lys Leu Thr Leu Ser Glu Val Thr Gly Gln Gly 
    370                 375                 380                 
Leu Cys Ile Gly Ala Val Pro Lys Thr His Gln Val Leu Cys Asn Thr 
385                 390                 395                 400 
Thr Gln Lys Thr Ser Asp Gly Ser Tyr Tyr Leu Val Ala Pro Thr Gly 
                405                 410                 415     
Thr Thr Trp Ala Cys Ser Thr Gly Leu Thr Pro Cys Ile Ser Thr Thr 
            420                 425                 430         
Ile Leu Asn Leu Thr Thr Asp Tyr Cys Val Leu Val Glu Leu Trp Pro 
        435                 440                 445             
Arg Val Thr Tyr His Ser Pro Ser Tyr Val Tyr His Gln Phe Glu Arg 
    450                 455                 460                 
Arg Ala Lys Tyr Lys Arg Glu Pro Val Ser Leu Thr Leu Ala Leu Leu 
465                 470                 475                 480 
Leu Gly Gly Leu Thr Met Gly Gly Ile Ala Ala Gly Val Gly Thr Gly 
                485                 490                 495     
Thr Thr Ala Leu Val Ala Thr Gln Gln Phe Gln Gln Leu Gln Ala Ala 
            500                 505                 510         
Met His Asp Asp Leu Lys Glu Val Glu Lys Ser Ile Thr Asn Leu Glu 
        515                 520                 525             
Lys Ser Leu Thr Ser Leu Ser Glu Val Val Leu Gln Asn Arg Arg Gly 
    530                 535                 540                 
Leu Asp Leu Leu Phe Leu Lys Arg Gly Gly Leu Cys Ala Phe Leu Lys 
545                 550                 555                 560 
Glu Glu Cys Cys Phe Tyr Ala Asp His Thr Gly Leu Val Arg Asp Ser 
                565                 570                 575     
Met Ala Lys Leu Arg Glu Arg Leu Ser Gln Arg Gln Lys Leu Phe Glu 
            580                 585                 590         
Ser Gln Gln Gly Trp Phe Glu Gly Leu Phe Asn Lys Ser Pro Trp Phe 
        595                 600                 605             
Thr Thr Leu Ile Ser Thr Ile Met Gly Pro Leu Ile Ile Leu Leu Leu 
    610                 615                 620                 
Ile Leu Leu Phe Gly Pro Cys Ile Leu Asn Arg Leu Val Gln Phe Ile 
625                 630                 635                 640 
Lys Asp Arg Ile Ser Val Val Gln Ala Leu Val Leu Thr Gln Gln Tyr 
                645                 650                 655     
His Gln Leu Lys Thr Ile Gly Asp Cys Lys Ser Arg Glu 
            660                 665                 

<210> 42
<211> 43
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence

<400> 42
Cys Phe Tyr Ala Asp His Thr Gly Leu Val Arg Asp Ser Met Ala Lys 
1               5                   10                  15      
Leu Arg Glu Arg Leu Ser Gln Arg Gln Lys Leu Phe Glu Ser Gln Gln 
            20                  25                  30          
Gly Trp Phe Glu Gly Leu Phe Asn Lys Ser Pro 
        35                  40              

<210> 43
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> nucleotide sequence

<400> 43
Gly Cys Cys Ala Ala Cys Cys Ala Gly Ala Thr Cys Ala Ala Cys Gly 
1               5                   10                  15      
Ala Cys Cys Thr 
            20  

<210> 44
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> nucleotide sequence

<400> 44
Gly Cys Cys Ala Ala Cys Gly Cys Cys Ala Thr Cys Ala Ala Cys Gly 
1               5                   10                  15      
Ala Cys Cys Thr 
            20  

<210> 45
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> nucleotide sequence

<400> 45
Cys Cys Cys Gly Thr Gly Thr Cys Cys Gly Gly Ala Cys Cys Thr Gly 
1               5                   10                  15      
Ala Gly 
        

<210> 46
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> nucleotide sequence

<400> 46
Gly Thr Thr Cys Thr Ala Gly Ala Cys Thr Thr Gly Thr Cys Cys Thr 
1               5                   10                  15      
Gly Ala Ala Thr Thr Thr Thr Cys Thr Gly Gly Thr Thr Ala 
            20                  25                  30  

<210> 47
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> amino acid sequence

<400> 47
Thr Tyr His Met Val Ser Gly Met Ser Leu 
1               5                   10  

<210> 48
<211> 1387
<212> PRT
<213> Artificial Sequence


<220> 
<223> amino acid sequence

<400> 48
Met Gly Gln Thr Lys Ser Lys Ile Lys Ser Lys Tyr Ala Ser Tyr Leu 
1               5                   10                  15      
Ser Phe Ile Lys Ile Leu Leu Lys Arg Gly Gly Val Lys Val Ser Thr 
            20                  25                  30          
Lys Asn Leu Ile Lys Leu Phe Gln Ile Ile Glu Gln Phe Cys Pro Trp 
        35                  40                  45              
Phe Pro Glu Gln Gly Thr Leu Asp Leu Lys Asp Trp Lys Arg Ile Gly 
    50                  55                  60                  
Lys Glu Leu Lys Gln Ala Gly Arg Lys Gly Asn Ile Ile Pro Leu Thr 
65                  70                  75                  80  
Val Trp Asn Asp Trp Ala Ile Ile Lys Ala Ala Leu Glu Pro Phe Gln 
                85                  90                  95      
Thr Glu Glu Asp Ser Val Ser Val Ser Asp Ala Pro Gly Ser Cys Ile 
            100                 105                 110         
Ile Asp Cys Asn Glu Asn Thr Arg Lys Lys Ser Gln Lys Glu Thr Glu 
        115                 120                 125             
Gly Leu His Cys Glu Tyr Val Ala Glu Pro Val Met Ala Gln Ser Thr 
    130                 135                 140                 
Gln Asn Val Asp Tyr Asn Gln Leu Gln Glu Val Ile Tyr Pro Glu Thr 
145                 150                 155                 160 
Leu Lys Leu Glu Gly Lys Gly Pro Glu Leu Val Gly Pro Ser Glu Ser 
                165                 170                 175     
Lys Pro Arg Gly Thr Ser Pro Leu Pro Ala Gly Gln Val Pro Val Thr 
            180                 185                 190         
Leu Gln Pro Gln Lys Gln Val Lys Glu Asn Lys Thr Gln Pro Pro Val 
        195                 200                 205             
Ala Tyr Gln Tyr Trp Pro Pro Ala Glu Leu Gln Tyr Arg Pro Pro Pro 
    210                 215                 220                 
Glu Ser Gln Tyr Gly Tyr Pro Gly Met Pro Pro Ala Pro Gln Gly Arg 
225                 230                 235                 240 
Ala Pro Tyr Pro Gln Pro Pro Thr Arg Arg Leu Asn Pro Thr Ala Pro 
                245                 250                 255     
Pro Ser Arg Gln Gly Ser Glu Leu His Glu Ile Ile Asp Lys Ser Arg 
            260                 265                 270         
Lys Glu Gly Asp Thr Glu Ala Trp Gln Phe Pro Val Thr Leu Glu Pro 
        275                 280                 285             
Met Pro Pro Gly Glu Gly Ala Gln Glu Gly Glu Pro Pro Thr Val Glu 
    290                 295                 300                 
Ala Arg Tyr Lys Ser Phe Ser Ile Lys Met Leu Lys Asp Met Lys Glu 
305                 310                 315                 320 
Gly Val Lys Gln Tyr Gly Pro Asn Ser Pro Tyr Met Arg Thr Leu Leu 
                325                 330                 335     
Asp Ser Ile Ala His Gly His Arg Leu Ile Pro Tyr Asp Trp Glu Ile 
            340                 345                 350         
Leu Ala Lys Ser Ser Leu Ser Pro Ser Gln Phe Leu Gln Phe Lys Thr 
        355                 360                 365             
Trp Trp Ile Asp Gly Val Gln Glu Gln Val Arg Arg Asn Arg Ala Ala 
    370                 375                 380                 
Asn Pro Pro Val Asn Ile Asp Ala Asp Gln Leu Leu Gly Ile Gly Gln 
385                 390                 395                 400 
Asn Trp Ser Thr Ile Ser Gln Gln Ala Leu Met Gln Asn Glu Ala Ile 
                405                 410                 415     
Glu Gln Val Arg Ala Ile Cys Leu Arg Ala Trp Glu Lys Ile Gln Asp 
            420                 425                 430         
Pro Gly Ser Thr Cys Pro Ser Phe Asn Thr Val Arg Gln Gly Ser Lys 
        435                 440                 445             
Glu Pro Tyr Pro Asp Phe Val Ala Arg Leu Gln Asp Val Ala Gln Lys 
    450                 455                 460                 
Ser Ile Ala Asp Glu Lys Ala Arg Lys Val Ile Val Glu Leu Met Ala 
465                 470                 475                 480 
Tyr Glu Asn Ala Asn Pro Glu Cys Gln Ser Ala Ile Lys Pro Leu Lys 
                485                 490                 495     
Gly Lys Val Pro Ala Gly Ser Asp Val Ile Ser Glu Tyr Val Lys Ala 
            500                 505                 510         
Cys Asp Gly Ile Gly Gly Ala Met His Lys Ala Met Leu Met Ala Gln 
        515                 520                 525             
Ala Ile Thr Gly Val Val Leu Gly Gly Gln Val Arg Thr Phe Gly Gly 
    530                 535                 540                 
Lys Cys Tyr Asn Cys Gly Gln Ile Gly His Leu Lys Lys Asn Cys Pro 
545                 550                 555                 560 
Val Leu Asn Lys Gln Asn Ile Thr Ile Gln Ala Thr Thr Thr Gly Arg 
                565                 570                 575     
Glu Pro Pro Asp Leu Cys Pro Arg Cys Lys Lys Gly Lys His Trp Ala 
            580                 585                 590         
Ser Gln Cys Arg Ser Lys Phe Asp Lys Asn Gly Gln Pro Leu Ser Gly 
        595                 600                 605             
Asn Glu Gln Arg Gly Gln Pro Gln Ala Pro Gln Gln Thr Gly Ala Phe 
    610                 615                 620                 
Pro Ile Gln Pro Phe Val Pro Gln Gly Phe Gln Gly Gln Gln Pro Pro 
625                 630                 635                 640 
Leu Ser Gln Val Phe Gln Gly Ile Ser Gln Leu Pro Gln Tyr Asn Asn 
                645                 650                 655     
Cys Pro Pro Pro Gln Ala Ala Val Gln Gln Gly Ser Gly Ala Thr Asn 
            660                 665                 670         
Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        675                 680                 685             
Met Asn Pro Ser Glu Met Gln Arg Lys Ala Pro Pro Arg Arg Arg Arg 
    690                 695                 700                 
His Arg Asn Arg Ala Pro Leu Thr His Lys Met Asn Lys Met Val Thr 
705                 710                 715                 720 
Ser Glu Glu Gln Met Lys Leu Pro Ser Thr Lys Lys Ala Glu Pro Pro 
                725                 730                 735     
Thr Trp Ala Gln Leu Lys Lys Leu Thr Gln Leu Ala Thr Lys Tyr Leu 
            740                 745                 750         
Glu Asn Thr Lys Val Thr Gln Thr Pro Glu Ser Met Leu Leu Ala Ala 
        755                 760                 765             
Leu Met Ile Val Ser Met Val Val Ser Leu Pro Met Pro Ala Gly Ala 
    770                 775                 780                 
Ala Ala Ala Asn Tyr Thr Tyr Trp Ala Tyr Val Pro Phe Pro Pro Leu 
785                 790                 795                 800 
Ile Arg Ala Val Thr Trp Met Asp Asn Pro Ile Glu Val Tyr Val Asn 
                805                 810                 815     
Asp Ser Val Trp Val Pro Gly Pro Ile Asp Asp Arg Cys Pro Ala Lys 
            820                 825                 830         
Pro Glu Glu Glu Gly Met Met Ile Asn Ile Ser Ile Gly Tyr Arg Tyr 
        835                 840                 845             
Pro Pro Ile Cys Leu Gly Arg Ala Pro Gly Cys Leu Met Pro Ala Val 
    850                 855                 860                 
Gln Asn Trp Leu Val Glu Val Pro Thr Val Ser Pro Ile Ser Arg Phe 
865                 870                 875                 880 
Thr Tyr His Met Val Ser Gly Met Ser Leu Arg Pro Arg Val Asn Tyr 
                885                 890                 895     
Leu Gln Asp Phe Ser Tyr Gln Arg Ser Leu Lys Phe Arg Pro Lys Gly 
            900                 905                 910         
Lys Pro Cys Pro Lys Glu Ile Pro Lys Glu Ser Lys Asn Thr Glu Val 
        915                 920                 925             
Leu Val Trp Glu Glu Cys Val Ala Asn Ser Ala Val Ile Leu Gln Asn 
    930                 935                 940                 
Asn Glu Phe Gly Thr Ile Ile Asp Trp Ala Pro Arg Gly Gln Phe Tyr 
945                 950                 955                 960 
His Asn Cys Ser Gly Gln Thr Gln Ser Cys Pro Ser Ala Gln Val Ser 
                965                 970                 975     
Pro Ala Val Asp Ser Asp Leu Thr Glu Ser Leu Asp Lys His Lys His 
            980                 985                 990         
Lys Lys Leu Gln Ser Phe Tyr Pro Trp Glu Trp Gly Glu Lys Gly Ile 
        995                 1000                1005            
Ser Thr Pro Arg Pro Lys Ile Val Ser Pro Val Ser Gly Pro Glu His 
    1010                1015                1020                
Pro Glu Leu Trp Arg Leu Thr Val Ala Ser His His Ile Arg Ile Trp 
1025                1030                1035                1040
Ser Gly Asn Gln Thr Leu Glu Thr Arg Asp Arg Lys Pro Phe Tyr Thr 
                1045                1050                1055    
Val Asp Leu Asn Ser Ser Leu Thr Val Pro Leu Gln Ser Cys Val Lys 
            1060                1065                1070        
Pro Pro Tyr Met Leu Val Val Gly Asn Ile Val Ile Lys Pro Asp Ser 
        1075                1080                1085            
Gln Thr Ile Thr Cys Glu Asn Cys Arg Leu Leu Thr Cys Ile Asp Ser 
    1090                1095                1100                
Thr Phe Asn Trp Gln His Arg Ile Leu Leu Val Arg Ala Arg Glu Gly 
1105                1110                1115                1120
Val Trp Ile Pro Val Ser Met Asp Arg Pro Trp Glu Ala Ser Pro Ser 
                1125                1130                1135    
Val His Ile Leu Thr Glu Val Leu Lys Gly Val Leu Asn Arg Ser Lys 
            1140                1145                1150        
Arg Phe Ile Phe Thr Leu Ile Ala Val Ile Met Gly Leu Ile Ala Val 
        1155                1160                1165            
Thr Ala Thr Ala Ala Val Ala Gly Val Ala Leu His Ser Ser Val Gln 
    1170                1175                1180                
Ser Val Asn Phe Val Asn Asp Trp Gln Lys Asn Ser Thr Arg Leu Trp 
1185                1190                1195                1200
Asn Ser Gln Ser Ser Ile Asp Gln Lys Leu Ala Asn Ala Ile Asn Asp 
                1205                1210                1215    
Leu Arg Gln Thr Val Ile Trp Met Gly Asp Arg Leu Met Ser Leu Glu 
            1220                1225                1230        
His Arg Phe Gln Leu Gln Cys Asp Trp Asn Thr Ser Asp Phe Cys Ile 
        1235                1240                1245            
Thr Pro Gln Ile Tyr Asn Glu Ser Glu His His Trp Asp Met Val Arg 
    1250                1255                1260                
Arg His Leu Gln Gly Arg Glu Asp Asn Leu Thr Leu Asp Ile Ser Lys 
1265                1270                1275                1280
Leu Lys Glu Gln Ile Phe Glu Ala Ser Lys Ala His Leu Asn Leu Val 
                1285                1290                1295    
Pro Gly Thr Glu Ala Ile Ala Gly Val Ala Asp Gly Leu Ala Asn Leu 
            1300                1305                1310        
Asn Pro Val Thr Trp Val Lys Thr Ile Gly Ser Thr Thr Ile Ile Asn 
        1315                1320                1325            
Leu Ile Leu Ile Leu Val Cys Leu Phe Cys Leu Leu Leu Val Cys Arg 
    1330                1335                1340                
Cys Thr Gln Gln Leu Arg Arg Asp Ser Asp His Arg Glu Arg Ala Met 
1345                1350                1355                1360
Met Thr Met Ala Val Leu Ser Lys Arg Lys Gly Gly Asn Val Gly Lys 
                1365                1370                1375    
Ser Lys Arg Asp Gln Ile Val Thr Val Ser Val 
            1380                1385        

<210> 49
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> amino acid sequence

<400> 49
Asn Ser Gln Ser Ser Ile Asp Gln Lys Leu Ala Asn Gln Ile Asn Asp 
1               5                   10                  15      
Leu Arg Gln Thr 
            20  

<210> 50
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> amino acid sequence

<400> 50
Asn Ser Gln Ser Ser Ile Asp Gln Lys Leu Ala Asn Ala Ile Asn Asp 
1               5                   10                  15      
Leu Arg Gln Thr 
            20  

<210> 51
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> amino acid sequence

<400> 51
Thr Gly Thr Thr Ala Leu Val Ala Thr Gln Gln Phe Gln Gln Leu Gln 
1               5                   10                  15      
Ala Ala Met His Asp Asp Leu Lys Glu Val Glu Lys Ser Ile Thr Asn 
            20                  25                  30          
Leu Glu Lys Ser Leu Thr Ser Leu Ser Glu Val Val Leu Gln Asn Arg 
        35                  40                  45              
Arg Gly Leu Asp Leu Leu Phe Leu Lys Glu Gly Gly Leu Cys Ala Ala 
    50                  55                  60                  
Leu Lys Glu Glu Cys Cys Phe Tyr Ala Asp His Thr Gly Leu Val Arg 
65                  70                  75                  80  
Asp Ser Met Ala Lys Leu Arg Glu Arg Leu Ser Gln Arg Gln Lys Leu 
                85                  90                  95      
Phe Glu Ser Gln Gln Gly Trp Phe Glu Gly Leu Phe Asn 
            100                 105                 

<210> 52
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> amino acid sequence

<400> 52
Thr Gly Thr Thr Ala Leu Val Ala Thr Gln Gln Phe Gln Gln Leu Gln 
1               5                   10                  15      
Ala Ala Met His Asp Asp Leu Lys Glu Val Glu Lys Ser Ile Thr Asn 
            20                  25                  30          
Leu Glu Lys Ser Leu Thr Ser Leu Ser Glu Val Val Leu Gln Asn Arg 
        35                  40                  45              
Arg Gly Leu Asp Leu Leu Phe Leu Lys Arg Gly Gly Leu Cys Ala Phe 
    50                  55                  60                  
Leu Lys Glu Glu Cys Cys Phe Tyr Ala Asp His Thr Gly Leu Val Arg 
65                  70                  75                  80  
Asp Ser Met Ala Lys Leu Arg Glu Arg Leu Ser Gln Arg Gln Lys Leu 
                85                  90                  95      
Phe Glu Ser Gln Gln Gly Trp Phe Glu Gly Leu Phe Asn 
            100                 105                 

<210> 53
<211> 62
<212> PRT
<213> Artificial Sequence


<220> 
<223> amino acid sequence

<400> 53
Thr Gly Thr Thr Ala Leu Val Ala Thr Gln Gln Phe Gln Gln Leu Gln 
1               5                   10                  15      
Ala Ala Met His Asp Asp Leu Lys Glu Val Glu Lys Ser Ile Thr Asn 
            20                  25                  30          
Leu Glu Lys Ser Leu Thr Ser Leu Ser Glu Val Val Leu Gln Asn Arg 
        35                  40                  45              
Arg Gly Leu Asp Leu Leu Phe Leu Lys Glu Gly Gly Leu Cys 
    50                  55                  60          

<210> 54
<211> 61
<212> PRT
<213> Artificial Sequence


<220> 
<223> amino acid sequence

<400> 54
Thr Gly Thr Thr Ala Leu Val Ala Thr Gln Gln Phe Gln Gln Leu Gln 
1               5                   10                  15      
Ala Ala Met His Asp Asp Leu Lys Glu Val Glu Lys Ser Ile Thr Asn 
            20                  25                  30          
Leu Glu Lys Ser Leu Thr Ser Leu Ser Glu Val Val Leu Gln Asn Arg 
        35                  40                  45              
Arg Gly Leu Asp Leu Leu Phe Leu Lys Glu Gly Gly Leu 
    50                  55                  60      

<210> 55
<211> 1387
<212> PRT
<213> Artificial Sequence


<220> 
<223> amino acid sequence

<400> 55
Met Gly Gln Thr Lys Ser Lys Ile Lys Ser Lys Tyr Ala Ser Tyr Leu 
1               5                   10                  15      
Ser Phe Ile Lys Ile Leu Leu Lys Arg Gly Gly Val Lys Val Ser Thr 
            20                  25                  30          
Lys Asn Leu Ile Lys Leu Phe Gln Ile Ile Glu Gln Phe Cys Pro Trp 
        35                  40                  45              
Phe Pro Glu Gln Gly Thr Leu Asp Leu Lys Asp Trp Lys Arg Ile Gly 
    50                  55                  60                  
Lys Glu Leu Lys Gln Ala Gly Arg Lys Gly Asn Ile Ile Pro Leu Thr 
65                  70                  75                  80  
Val Trp Asn Asp Trp Ala Ile Ile Lys Ala Ala Leu Glu Pro Phe Gln 
                85                  90                  95      
Thr Glu Glu Asp Ser Val Ser Val Ser Asp Ala Pro Gly Ser Cys Ile 
            100                 105                 110         
Ile Asp Cys Asn Glu Asn Thr Arg Lys Lys Ser Gln Lys Glu Thr Glu 
        115                 120                 125             
Gly Leu His Cys Glu Tyr Val Ala Glu Pro Val Met Ala Gln Ser Thr 
    130                 135                 140                 
Gln Asn Val Asp Tyr Asn Gln Leu Gln Glu Val Ile Tyr Pro Glu Thr 
145                 150                 155                 160 
Leu Lys Leu Glu Gly Lys Gly Pro Glu Leu Val Gly Pro Ser Glu Ser 
                165                 170                 175     
Lys Pro Arg Gly Thr Ser Pro Leu Pro Ala Gly Gln Val Pro Val Thr 
            180                 185                 190         
Leu Gln Pro Gln Lys Gln Val Lys Glu Asn Lys Thr Gln Pro Pro Val 
        195                 200                 205             
Ala Tyr Gln Tyr Trp Pro Pro Ala Glu Leu Gln Tyr Arg Pro Pro Pro 
    210                 215                 220                 
Glu Ser Gln Tyr Gly Tyr Pro Gly Met Pro Pro Ala Pro Gln Gly Arg 
225                 230                 235                 240 
Ala Pro Tyr Pro Gln Pro Pro Thr Arg Arg Leu Asn Pro Thr Ala Pro 
                245                 250                 255     
Pro Ser Arg Gln Gly Ser Glu Leu His Glu Ile Ile Asp Lys Ser Arg 
            260                 265                 270         
Lys Glu Gly Asp Thr Glu Ala Trp Gln Phe Pro Val Thr Leu Glu Pro 
        275                 280                 285             
Met Pro Pro Gly Glu Gly Ala Gln Glu Gly Glu Pro Pro Thr Val Glu 
    290                 295                 300                 
Ala Arg Tyr Lys Ser Phe Ser Ile Lys Met Leu Lys Asp Met Lys Glu 
305                 310                 315                 320 
Gly Val Lys Gln Tyr Gly Pro Asn Ser Pro Tyr Met Arg Thr Leu Leu 
                325                 330                 335     
Asp Ser Ile Ala His Gly His Arg Leu Ile Pro Tyr Asp Trp Glu Ile 
            340                 345                 350         
Leu Ala Lys Ser Ser Leu Ser Pro Ser Gln Phe Leu Gln Phe Lys Thr 
        355                 360                 365             
Trp Trp Ile Asp Gly Val Gln Glu Gln Val Arg Arg Asn Arg Ala Ala 
    370                 375                 380                 
Asn Pro Pro Val Asn Ile Asp Ala Asp Gln Leu Leu Gly Ile Gly Gln 
385                 390                 395                 400 
Asn Trp Ser Thr Ile Ser Gln Gln Ala Leu Met Gln Asn Glu Ala Ile 
                405                 410                 415     
Glu Gln Val Arg Ala Ile Cys Leu Arg Ala Trp Glu Lys Ile Gln Asp 
            420                 425                 430         
Pro Gly Ser Thr Cys Pro Ser Phe Asn Thr Val Arg Gln Gly Ser Lys 
        435                 440                 445             
Glu Pro Tyr Pro Asp Phe Val Ala Arg Leu Gln Asp Val Ala Gln Lys 
    450                 455                 460                 
Ser Ile Ala Asp Glu Lys Ala Arg Lys Val Ile Val Glu Leu Met Ala 
465                 470                 475                 480 
Tyr Glu Asn Ala Asn Pro Glu Cys Gln Ser Ala Ile Lys Pro Leu Lys 
                485                 490                 495     
Gly Lys Val Pro Ala Gly Ser Asp Val Ile Ser Glu Tyr Val Lys Ala 
            500                 505                 510         
Cys Asp Gly Ile Gly Gly Ala Met His Lys Ala Met Leu Met Ala Gln 
        515                 520                 525             
Ala Ile Thr Gly Val Val Leu Gly Gly Gln Val Arg Thr Phe Gly Gly 
    530                 535                 540                 
Lys Cys Tyr Asn Cys Gly Gln Ile Gly His Leu Lys Lys Asn Cys Pro 
545                 550                 555                 560 
Val Leu Asn Lys Gln Asn Ile Thr Ile Gln Ala Thr Thr Thr Gly Arg 
                565                 570                 575     
Glu Pro Pro Asp Leu Cys Pro Arg Cys Lys Lys Gly Lys His Trp Ala 
            580                 585                 590         
Ser Gln Cys Arg Ser Lys Phe Asp Lys Asn Gly Gln Pro Leu Ser Gly 
        595                 600                 605             
Asn Glu Gln Arg Gly Gln Pro Gln Ala Pro Gln Gln Thr Gly Ala Phe 
    610                 615                 620                 
Pro Ile Gln Pro Phe Val Pro Gln Gly Phe Gln Gly Gln Gln Pro Pro 
625                 630                 635                 640 
Leu Ser Gln Val Phe Gln Gly Ile Ser Gln Leu Pro Gln Tyr Asn Asn 
                645                 650                 655     
Cys Pro Pro Pro Gln Ala Ala Val Gln Gln Gly Ser Gly Ala Thr Asn 
            660                 665                 670         
Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        675                 680                 685             
Met Asn Pro Ser Glu Met Gln Arg Lys Ala Pro Pro Arg Arg Arg Arg 
    690                 695                 700                 
His Arg Asn Arg Ala Pro Leu Thr His Lys Met Asn Lys Met Val Thr 
705                 710                 715                 720 
Ser Glu Glu Gln Met Lys Leu Pro Ser Thr Lys Lys Ala Glu Pro Pro 
                725                 730                 735     
Thr Trp Ala Gln Leu Lys Lys Leu Thr Gln Leu Ala Thr Lys Tyr Leu 
            740                 745                 750         
Glu Asn Thr Lys Val Thr Gln Thr Pro Glu Ser Met Leu Leu Ala Ala 
        755                 760                 765             
Leu Met Ile Val Ser Met Val Val Ser Leu Pro Met Pro Ala Gly Ala 
    770                 775                 780                 
Ala Ala Ala Asn Tyr Thr Tyr Trp Ala Tyr Val Pro Phe Pro Pro Leu 
785                 790                 795                 800 
Ile Arg Ala Val Thr Trp Met Asp Asn Pro Ile Glu Val Tyr Val Asn 
                805                 810                 815     
Asp Ser Val Trp Val Pro Gly Pro Ile Asp Asp Arg Cys Pro Ala Lys 
            820                 825                 830         
Pro Glu Glu Glu Gly Met Met Ile Asn Ile Ser Ile Gly Tyr Arg Tyr 
        835                 840                 845             
Pro Pro Ile Cys Leu Gly Arg Ala Pro Gly Cys Leu Met Pro Ala Val 
    850                 855                 860                 
Gln Asn Trp Leu Val Glu Val Pro Thr Val Ser Pro Ile Ser Arg Phe 
865                 870                 875                 880 
Thr Tyr His Met Val Ser Gly Met Ser Leu Arg Pro Arg Val Asn Tyr 
                885                 890                 895     
Leu Gln Asp Phe Ser Tyr Gln Arg Ser Leu Lys Phe Arg Pro Lys Gly 
            900                 905                 910         
Lys Pro Cys Pro Lys Glu Ile Pro Lys Glu Ser Lys Asn Thr Glu Val 
        915                 920                 925             
Leu Val Trp Glu Glu Cys Val Ala Asn Ser Ala Val Ile Leu Gln Asn 
    930                 935                 940                 
Asn Glu Phe Gly Thr Ile Ile Asp Trp Ala Pro Arg Gly Gln Phe Tyr 
945                 950                 955                 960 
His Asn Cys Ser Gly Gln Thr Gln Ser Cys Pro Ser Ala Gln Val Ser 
                965                 970                 975     
Pro Ala Val Asp Ser Asp Leu Thr Glu Ser Leu Asp Lys His Lys His 
            980                 985                 990         
Lys Lys Leu Gln Ser Phe Tyr Pro Trp Glu Trp Gly Glu Lys Gly Ile 
        995                 1000                1005            
Ser Thr Pro Arg Pro Lys Ile Val Ser Pro Val Ser Gly Pro Glu His 
    1010                1015                1020                
Pro Glu Leu Trp Arg Leu Thr Val Ala Ser His His Ile Arg Ile Trp 
1025                1030                1035                1040
Ser Gly Asn Gln Thr Leu Glu Thr Arg Asp Arg Lys Pro Phe Tyr Thr 
                1045                1050                1055    
Val Asp Leu Asn Ser Ser Leu Thr Val Pro Leu Gln Ser Cys Val Lys 
            1060                1065                1070        
Pro Pro Tyr Met Leu Val Val Gly Asn Ile Val Ile Lys Pro Asp Ser 
        1075                1080                1085            
Gln Thr Ile Thr Cys Glu Asn Cys Arg Leu Leu Thr Cys Ile Asp Ser 
    1090                1095                1100                
Thr Phe Asn Trp Gln His Arg Ile Leu Leu Val Arg Ala Arg Glu Gly 
1105                1110                1115                1120
Val Trp Ile Pro Val Ser Met Asp Arg Pro Trp Glu Ala Ser Pro Ser 
                1125                1130                1135    
Val His Ile Leu Thr Glu Val Leu Lys Gly Val Leu Asn Arg Ser Lys 
            1140                1145                1150        
Arg Phe Ile Phe Thr Leu Ile Ala Val Ile Met Gly Leu Ile Ala Val 
        1155                1160                1165            
Thr Ala Thr Ala Ala Val Ala Gly Val Ala Leu His Ser Ser Val Gln 
    1170                1175                1180                
Ser Val Asn Phe Val Asn Asp Trp Gln Lys Asn Ser Thr Arg Leu Trp 
1185                1190                1195                1200
Asn Ser Gln Ser Ser Ile Asp Gln Lys Leu Ala Asn Gln Ile Asn Asp 
                1205                1210                1215    
Leu Arg Gln Thr Val Ile Trp Met Gly Asp Arg Leu Met Ser Leu Glu 
            1220                1225                1230        
His Arg Phe Gln Leu Gln Cys Asp Trp Asn Thr Ser Asp Phe Cys Ile 
        1235                1240                1245            
Thr Pro Gln Ile Tyr Asn Glu Ser Glu His His Trp Asp Met Val Arg 
    1250                1255                1260                
Arg His Leu Gln Gly Arg Glu Asp Asn Leu Thr Leu Asp Ile Ser Lys 
1265                1270                1275                1280
Leu Lys Glu Gln Ile Phe Glu Ala Ser Lys Ala His Leu Asn Leu Val 
                1285                1290                1295    
Pro Gly Thr Glu Ala Ile Ala Gly Val Ala Asp Gly Leu Ala Asn Leu 
            1300                1305                1310        
Asn Pro Val Thr Trp Val Lys Thr Ile Gly Ser Thr Thr Ile Ile Asn 
        1315                1320                1325            
Leu Ile Leu Ile Leu Val Cys Leu Phe Cys Leu Leu Leu Val Cys Arg 
    1330                1335                1340                
Cys Thr Gln Gln Leu Arg Arg Asp Ser Asp His Arg Glu Arg Ala Met 
1345                1350                1355                1360
Met Thr Met Ala Val Leu Ser Lys Arg Lys Gly Gly Asn Val Gly Lys 
                1365                1370                1375    
Ser Lys Arg Asp Gln Ile Val Thr Val Ser Val 
            1380                1385        

