                         SEQUENCE LISTING

<110>  Janssen Biotech, Inc.
       Chiu, Mark
       Whitaker, Brian
       Zhang, Di
 
<120>  Fc gamma receptor II  BINDING FIBRONECTIN TYPE III DOMAINS, THEIR
        CONJUGATES AND MULTISPECIFIC MOLECULES COMPRISING THEM

<130>  JBI5136WOPC1

<140>  To Be Assigned
<141>  2018-08-24

<150>  62/550152
<151>  2017-08-25

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210>  2
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Met Glu Thr Gln Met Ser Gln Asn Val Cys Pro Arg Asn Leu 
1               5                   10                  15      


Trp Leu Leu Gln Pro Leu Thr Val Leu Leu Leu Leu Ala Ser Ala Asp 
            20                  25                  30          


Ser Gln Ala Ala Pro Pro Lys Ala Val Leu Lys Leu Glu Pro Pro Trp 
        35                  40                  45              


Ile Asn Val Leu Gln Glu Asp Ser Val Thr Leu Thr Cys Gln Gly Ala 
    50                  55                  60                  


Arg Ser Pro Glu Ser Asp Ser Ile Gln Trp Phe His Asn Gly Asn Leu 
65                  70                  75                  80  


Ile Pro Thr His Thr Gln Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn 
                85                  90                  95      


Asp Ser Gly Glu Tyr Thr Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp 
            100                 105                 110         


Pro Val His Leu Thr Val Leu Ser Glu Trp Leu Val Leu Gln Thr Pro 
        115                 120                 125             


His Leu Glu Phe Gln Glu Gly Glu Thr Ile Met Leu Arg Cys His Ser 
    130                 135                 140                 


Trp Lys Asp Lys Pro Leu Val Lys Val Thr Phe Phe Gln Asn Gly Lys 
145                 150                 155                 160 


Ser Gln Lys Phe Ser His Leu Asp Pro Thr Phe Ser Ile Pro Gln Ala 
                165                 170                 175     


Asn His Ser His Ser Gly Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr 
            180                 185                 190         


Thr Leu Phe Ser Ser Lys Pro Val Thr Ile Thr Val Gln Val Pro Ser 
        195                 200                 205             


Met Gly Ser Ser Ser Pro Met Gly Ile Ile Val Ala Val Val Ile Ala 
    210                 215                 220                 


Thr Ala Val Ala Ala Ile Val Ala Ala Val Val Ala Leu Ile Tyr Cys 
225                 230                 235                 240 


Arg Lys Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala Ala 
                245                 250                 255     


Gln Phe Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg Gln 
            260                 265                 270         


Leu Glu Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr Met 
        275                 280                 285             


Thr Leu Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr Leu 
    290                 295                 300                 


Thr Leu Pro Pro Asn Asp His Val Asn Ser Asn Asn 
305                 310                 315     


<210>  3
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Ile Leu Ser Phe Leu Pro Val Leu Ala Thr Glu Ser Asp Trp 
1               5                   10                  15      


Ala Asp Cys Lys Ser Pro Gln Pro Trp Gly His Met Leu Leu Trp Thr 
            20                  25                  30          


Ala Val Leu Phe Leu Ala Pro Val Ala Gly Thr Pro Ala Ala Pro Pro 
        35                  40                  45              


Lys Ala Val Leu Lys Leu Glu Pro Gln Trp Ile Asn Val Leu Gln Glu 
    50                  55                  60                  


Asp Ser Val Thr Leu Thr Cys Arg Gly Thr His Ser Pro Glu Ser Asp 
65                  70                  75                  80  


Ser Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro Thr His Thr Gln 
                85                  90                  95      


Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser Gly Glu Tyr Thr 
            100                 105                 110         


Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val His Leu Thr Val 
        115                 120                 125             


Leu Ser Glu Trp Leu Val Leu Gln Thr Pro His Leu Glu Phe Gln Glu 
    130                 135                 140                 


Gly Glu Thr Ile Val Leu Arg Cys His Ser Trp Lys Asp Lys Pro Leu 
145                 150                 155                 160 


Val Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Lys Lys Phe Ser Arg 
                165                 170                 175     


Ser Asp Pro Asn Phe Ser Ile Pro Gln Ala Asn His Ser His Ser Gly 
            180                 185                 190         


Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu Tyr Ser Ser Lys 
        195                 200                 205             


Pro Val Thr Ile Thr Val Gln Ala Pro Ser Ser Ser Pro Met Gly Ile 
    210                 215                 220                 


Ile Val Ala Val Val Thr Gly Ile Ala Val Ala Ala Ile Val Ala Ala 
225                 230                 235                 240 


Val Val Ala Leu Ile Tyr Cys Arg Lys Lys Arg Ile Ser Ala Leu Pro 
                245                 250                 255     


Gly Tyr Pro Glu Cys Arg Glu Met Gly Glu Thr Leu Pro Glu Lys Pro 
            260                 265                 270         


Ala Asn Pro Thr Asn Pro Asp Glu Ala Asp Lys Val Gly Ala Glu Asn 
        275                 280                 285             


Thr Ile Thr Tyr Ser Leu Leu Met His Pro Asp Ala Leu Glu Glu Pro 
    290                 295                 300                 


Asp Asp Gln Asn Arg Ile 
305                 310 


<210>  4
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tencon

<400>  4

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 
1               5                   10                  15      


Leu Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Asn Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Glu Phe Thr Thr 
                85                  


<210>  5
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tencon27

<400>  5

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  6
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  6

Gly Ser Gly Ser 
1               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  7

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  8
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  8

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  9
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  9

Ala Pro Ala Pro 
1               


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  10

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10  


<210>  11
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linkder

<400>  11

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro 
            20  


<210>  12
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  12

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Ala Pro 
        35                  40  


<210>  13
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  13

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala Ala Ala 
            20                  25                  


<210>  14
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linkder

<400>  14

Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser 
            20      


<210>  15
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin variant

<400>  15

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  16
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2BS6 protein

<400>  16

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gln Tyr Ala Ala Trp Tyr 
65                  70                  75                  80  


Leu Pro Arg His His Glu Ala Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  17
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2BS9 protein

<400>  17

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Tyr Tyr Leu Glu Tyr Trp Arg Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gln Ile His Gly Val Lys Gly Gly Gln Tyr Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  18
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2BS12 protein

<400>  18

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Ala Tyr Ala Glu Tyr Trp Glu Gly Gly Glu Ala Val Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gln Ile Asn Gly Val Lys Gly Gly Phe Trp Ser 
65                  70                  75                  80  


Ile Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  19
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2BS26 protein

<400>  19

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Ala Tyr Ile Glu Tyr Trp Thr Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Trp Ile His Gly Val Lys Gly Gly Ala Trp Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  20
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2BS29_protein

<400>  20

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Tyr Tyr Trp Glu Tyr Arg Val Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Tyr Ile Asn Gly Val Lys Gly Gly Glu Glu Ser 
65                  70                  75                  80  


Arg Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  21
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2BS39 protein

<400>  21

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ser His Gly Pro Trp Tyr 
65                  70                  75                  80  


Asn Tyr Gly Glu Trp Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  22
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2BS56 protein

<400>  22

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Ala Tyr Trp Glu Tyr Arg Lys Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Leu Ile Tyr Gly Val Lys Gly Gly Trp Gln Ser 
65                  70                  75                  80  


Lys Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  23
<211>  291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R2BS6 cDNA

<400>  23
ctgccggcgc cgaaaaacct ggttgtttct cgtgttaccg aagactctgc gcgtctgtct       60

tggaccgcgc cggacgcggc gttcgactct ttcctgatcc agtaccagga atctgaaaaa      120

gttggtgaag cgatcgtgct gaccgttccg ggttctgaac gttcttacga cctgaccggt      180

ctgaaaccgg gtaccgaata caccgtttct atctacggtg ttcaatatgc ggcgtggtat      240

ctgccgcgtc accacgaggc gagcaacccg ctgtctgcga tcttcaccac c               291


<210>  24
<211>  267
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R2BS9 cDNA

<400>  24
ctgccggcgc cgaaaaacct ggttgtttct cgtgttaccg aagactctgc gcgtctgtct       60

tggaccgcgc cggacgcggc gttcgactct ttctggattt attacctgga gtattggcgt      120

ggcggtgaag cgatcgttct gaccgttccg ggttctgaac gttcttacga cctgaccggt      180

ctgaaaccgg gtaccgaata tttcgttcaa attcacggcg ttaagggcgg tcaatatagt      240

tatccactgt ctgcgatctt caccacc                                          267


<210>  25
<211>  267
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R2BS12 cDNA

<400>  25
ctgccggcgc cgaaaaacct ggttgtttct cgtgttaccg aagactctgc gcgtctgtct       60

tggaccgcgc cggacgcggc gttcgactct tttctgatcg cgtatgcgga atattgggag      120

ggcggtgaag cggtcgttct gaccgttccg ggttctgaac gttcttacga cctgaccggt      180

ctgaaaccgg gtaccgaata tttcgttcaa atcaatggcg ttaagggtgg tttctggagt      240

atcccactgt ctgcgatctt caccacc                                          267


<210>  26
<211>  267
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R2BS26 cDNA

<400>  26
ctgccggcgc cgaaaaacct ggttgtttct cgtgttaccg aagactctgc gcgtctgtct       60

tggaccgcgc cggacgcggc gttcgactct tttccgatcg cgtatatcga gtattggact      120

ggcggtgaag cgatcgttct gaccgttccg ggttctgaac gttcttacga cctgaccggt      180

ctgaaaccgg gtaccgaata tttcgtttgg attcacggcg ttaagggtgg tgcgtggtcc      240

agcccgctgt ctgcgatctt caccacc                                          267


<210>  27
<211>  267
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R2BS29 cDNA

<400>  27
ctgccggcgc cgaaaaacct ggttgtttct cgtgttaccg aagactctgc gcgtctgtct       60

tggaccgcgc cggacgcggc gttcgactct tttccgatct attattggga atatcgtgtt      120

ggcggtgaag cgatcgttct gaccgttccg ggttctgaac gttcttacga cctgaccggt      180

ctgaaaccgg gtaccgaata cttcgtttat atcaatggtg ttaaaggtgg cgaggagagt      240

cgtccgctgt ctgcgatctt caccacc                                          267


<210>  28
<211>  288
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R2BS39 cDNA

<400>  28
ctgccggcgc cgaaaaacct ggttgtttct cgtgttaccg aagactctgc gcgtctgtct       60

tggaccgcgc cggacgcggc gttcgactct ttcctgatcc agtaccagga atctgaaaaa      120

gttggtgaag cgatcgtgct gaccgttccg ggttctgaac gttcttacga cctgaccggt      180

ctgaaaccgg gtaccgaata caccgtttct atctacggtg tgagccacgg cccgtggtat      240

aattatggcg agtggcgttc taacccgctg tctgcgatct tcaccacc                   288


<210>  29
<211>  267
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R2BS56 cDNA

<400>  29
ctgccggcgc cgaaaaacct ggttgtttct cgtgttaccg aagactctgc gcgtctgtct       60

tggaccgcgc cggacgcggc gttcgactct tttagcattg cgtactggga gtatcgtaaa      120

ggcggtgaag cgatcgttct gaccgttccg ggttctgaac gttcttacga cctgaccggt      180

ctgaaaccgg gtaccgaata tttcgttctg atctatggtg tcaagggcgg ttggcaatcc      240

aaaccactgt ctgcgatctt caccacc                                          267


<210>  30
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hcOX40SF2IgG2sigma_HC

<400>  30

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Lys Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Tyr Pro Asn Asn Gly Gly Ser Thr Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Gly Tyr His Gly Pro His Leu Asp Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Ser Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Ala Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  31
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lcOX40SF2_LC

<400>  31

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Ala Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  32
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hcOX40SF2IgG2sigma _R2BS6_HC-C

<400>  32

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Lys Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Tyr Pro Asn Asn Gly Gly Ser Thr Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Gly Tyr His Gly Pro His Leu Asp Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Ser Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Ala Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
        435                 440                 445             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    450                 455                 460                 


Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
465                 470                 475                 480 


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
                485                 490                 495     


Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala 
            500                 505                 510         


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
        515                 520                 525             


Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gln Tyr 
    530                 535                 540                 


Ala Ala Trp Tyr Leu Pro Arg His His Glu Ala Ser Asn Pro Leu Ser 
545                 550                 555                 560 


Ala Ile Phe Thr Thr 
                565 


<210>  33
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hcOX40SF2IgG2sigma _R2BS9_HC-C

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Lys Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Tyr Pro Asn Asn Gly Gly Ser Thr Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Gly Tyr His Gly Pro His Leu Asp Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Ser Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Ala Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
        435                 440                 445             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    450                 455                 460                 


Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
465                 470                 475                 480 


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
                485                 490                 495     


Asp Ser Phe Trp Ile Tyr Tyr Leu Glu Tyr Trp Arg Gly Gly Glu Ala 
            500                 505                 510         


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
        515                 520                 525             


Leu Lys Pro Gly Thr Glu Tyr Phe Val Gln Ile His Gly Val Lys Gly 
    530                 535                 540                 


Gly Gln Tyr Ser Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555         


<210>  34
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hcOX40SF2IgG2sigma _R2BS12_HC-C

<400>  34

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Lys Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Tyr Pro Asn Asn Gly Gly Ser Thr Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Gly Tyr His Gly Pro His Leu Asp Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Ser Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Ala Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
        435                 440                 445             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    450                 455                 460                 


Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
465                 470                 475                 480 


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
                485                 490                 495     


Asp Ser Phe Leu Ile Ala Tyr Ala Glu Tyr Trp Glu Gly Gly Glu Ala 
            500                 505                 510         


Val Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
        515                 520                 525             


Leu Lys Pro Gly Thr Glu Tyr Phe Val Gln Ile Asn Gly Val Lys Gly 
    530                 535                 540                 


Gly Phe Trp Ser Ile Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555         


<210>  35
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hcOX40SF2IgG2sigma _R2BS26_HC-C

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Lys Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Tyr Pro Asn Asn Gly Gly Ser Thr Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Gly Tyr His Gly Pro His Leu Asp Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Ser Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Ala Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
        435                 440                 445             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    450                 455                 460                 


Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
465                 470                 475                 480 


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
                485                 490                 495     


Asp Ser Phe Pro Ile Ala Tyr Ile Glu Tyr Trp Thr Gly Gly Glu Ala 
            500                 505                 510         


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
        515                 520                 525             


Leu Lys Pro Gly Thr Glu Tyr Phe Val Trp Ile His Gly Val Lys Gly 
    530                 535                 540                 


Gly Ala Trp Ser Ser Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555         


<210>  36
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hcOX40SF2IgG2sigma _R2BS29_HC-C

<400>  36

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Lys Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Tyr Pro Asn Asn Gly Gly Ser Thr Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Gly Tyr His Gly Pro His Leu Asp Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Ser Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Ala Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
        435                 440                 445             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    450                 455                 460                 


Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
465                 470                 475                 480 


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
                485                 490                 495     


Asp Ser Phe Pro Ile Tyr Tyr Trp Glu Tyr Arg Val Gly Gly Glu Ala 
            500                 505                 510         


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
        515                 520                 525             


Leu Lys Pro Gly Thr Glu Tyr Phe Val Tyr Ile Asn Gly Val Lys Gly 
    530                 535                 540                 


Gly Glu Glu Ser Arg Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555         


<210>  37
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hcOX40SF2IgG2sigma _R2BS39_HC-C

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Lys Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Tyr Pro Asn Asn Gly Gly Ser Thr Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Gly Tyr His Gly Pro His Leu Asp Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Ser Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Ala Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
        435                 440                 445             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    450                 455                 460                 


Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
465                 470                 475                 480 


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
                485                 490                 495     


Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala 
            500                 505                 510         


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
        515                 520                 525             


Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ser His 
    530                 535                 540                 


Gly Pro Trp Tyr Asn Tyr Gly Glu Trp Arg Ser Asn Pro Leu Ser Ala 
545                 550                 555                 560 


Ile Phe Thr Thr 
                


<210>  38
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hcOX40SF2IgG2sigma _R2BS56_HC-C

<400>  38

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Lys Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Tyr Pro Asn Asn Gly Gly Ser Thr Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Gly Tyr His Gly Pro His Leu Asp Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Ser Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Ala Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
        435                 440                 445             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    450                 455                 460                 


Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
465                 470                 475                 480 


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
                485                 490                 495     


Asp Ser Phe Ser Ile Ala Tyr Trp Glu Tyr Arg Lys Gly Gly Glu Ala 
            500                 505                 510         


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
        515                 520                 525             


Leu Lys Pro Gly Thr Glu Tyr Phe Val Leu Ile Tyr Gly Val Lys Gly 
    530                 535                 540                 


Gly Trp Gln Ser Lys Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555         


<210>  39
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hcOX40SF2IgG1_HC

<400>  39

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Lys Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Tyr Pro Asn Asn Gly Gly Ser Thr Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Gly Tyr His Gly Pro His Leu Asp Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  40
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hcOX40SF2IgG2sigma_R2BS29_HC-N

<400>  40

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Tyr Tyr Trp Glu Tyr Arg Val Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Tyr Ile Asn Gly Val Lys Gly Gly Glu Glu Ser 
65                  70                  75                  80  


Arg Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly Gly 
                85                  90                  95      


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
            100                 105                 110         


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys 
        115                 120                 125             


Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Lys Asp Tyr Thr Met His 
    130                 135                 140                 


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Gly Ile 
145                 150                 155                 160 


Tyr Pro Asn Asn Gly Gly Ser Thr Tyr Asn Gln Asn Phe Lys Asp Arg 
                165                 170                 175     


Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu 
            180                 185                 190         


Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Met 
        195                 200                 205             


Gly Tyr His Gly Pro His Leu Asp Phe Asp Val Trp Gly Gln Gly Thr 
    210                 215                 220                 


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
225                 230                 235                 240 


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
                245                 250                 255     


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
            260                 265                 270         


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
        275                 280                 285             


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
    290                 295                 300                 


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
305                 310                 315                 320 


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
                325                 330                 335     


Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Ser Ser Val Phe Leu Phe 
            340                 345                 350         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        355                 360                 365             


Thr Cys Val Val Val Asp Val Ser Ala Glu Asp Pro Glu Val Gln Phe 
    370                 375                 380                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
385                 390                 395                 400 


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
                405                 410                 415     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            420                 425                 430         


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr 
        435                 440                 445             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    450                 455                 460                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
465                 470                 475                 480 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                485                 490                 495     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
            500                 505                 510         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        515                 520                 525             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    530                 535                 540                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555     


<210>  41
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lcOX40SF2_R2BS29_LC-N

<400>  41

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Tyr Tyr Trp Glu Tyr Arg Val Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Tyr Ile Asn Gly Val Lys Gly Gly Glu Glu Ser 
65                  70                  75                  80  


Arg Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly Gly 
                85                  90                  95      


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
            100                 105                 110         


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
        115                 120                 125             


Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Ala Ala Val Ala Trp 
    130                 135                 140                 


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Trp Ala 
145                 150                 155                 160 


Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                165                 170                 175     


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
            180                 185                 190         


Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Asn Tyr Pro Leu Thr Phe Gly 
        195                 200                 205             


Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val 
    210                 215                 220                 


Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
225                 230                 235                 240 


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
                245                 250                 255     


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
            260                 265                 270         


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
        275                 280                 285             


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
    290                 295                 300                 


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
305                 310                 315                 320 


Gly Glu Cys 
            


<210>  42
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lcOX40SF2_R2BS29_LC-C

<400>  42

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Ala Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys 
225                 230                 235                 240 


Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp 
                245                 250                 255     


Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro Ile Tyr Tyr Trp Glu 
            260                 265                 270         


Tyr Arg Val Gly Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu 
        275                 280                 285             


Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Phe Val 
    290                 295                 300                 


Tyr Ile Asn Gly Val Lys Gly Gly Glu Glu Ser Arg Pro Leu Ser Ala 
305                 310                 315                 320 


Ile Phe Thr Thr 
                


<210>  43
<211>  561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hcOX40SF2IgG1 _R2BS29_HC-C

<400>  43

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Lys Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Tyr Pro Asn Asn Gly Gly Ser Thr Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Gly Tyr His Gly Pro His Leu Asp Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val 
465                 470                 475                 480 


Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro 
                485                 490                 495     


Asp Ala Ala Phe Asp Ser Phe Pro Ile Tyr Tyr Trp Glu Tyr Arg Val 
            500                 505                 510         


Gly Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr 
        515                 520                 525             


Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Phe Val Tyr Ile Asn 
    530                 535                 540                 


Gly Val Lys Gly Gly Glu Glu Ser Arg Pro Leu Ser Ala Ile Phe Thr 
545                 550                 555                 560 


Thr 
    


<210>  44
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro 
            180                 185                 190         


Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val 
        195                 200                 205             


Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln 
    210                 215                 220                 


Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn 
225                 230                 235                 240 


Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly 
                245                 250                 255     


Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg 
            260                 265                 270         


Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Gln Leu Pro Thr Pro 
        275                 280                 285             


Val Trp Phe His Val Leu Phe Tyr Leu Ala Val Gly Ile Met Phe Leu 
    290                 295                 300                 


Val Asn Thr Val Leu Trp Val Thr Ile Arg Lys Glu Leu Lys Arg Lys 
305                 310                 315                 320 


Lys Lys Trp Asp Leu Glu Ile Ser Leu Asp Ser Gly His Glu Lys Lys 
                325                 330                 335     


Val Ile Ser Ser Leu Gln Glu Asp Arg His Leu Glu Glu Glu Leu Lys 
            340                 345                 350         


Cys Gln Glu Gln Lys Glu Glu Gln Leu Gln Glu Gly Val His Arg Lys 
        355                 360                 365             


Glu Pro Gln Gly Ala Thr 
    370                 


<210>  45
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ala Glu Gly Thr Leu Trp Gln Ile Leu Cys Val Ser Ser Asp Ala 
1               5                   10                  15      


Gln Pro Gln Thr Phe Glu Gly Val Lys Gly Ala Asp Pro Pro Thr Leu 
            20                  25                  30          


Pro Pro Gly Ser Phe Leu Pro Gly Pro Val Leu Trp Trp Gly Ser Leu 
        35                  40                  45              


Ala Arg Leu Gln Thr Glu Lys Ser Asp Glu Val Ser Arg Lys Gly Asn 
    50                  55                  60                  


Trp Trp Val Thr Glu Met Gly Gly Gly Ala Gly Glu Arg Leu Phe Thr 
65                  70                  75                  80  


Ser Ser Cys Leu Val Gly Leu Val Pro Leu Gly Leu Arg Ile Ser Leu 
                85                  90                  95      


Val Thr Cys Pro Leu Gln Cys Gly Ile Met Trp Gln Leu Leu Leu Pro 
            100                 105                 110         


Thr Ala Leu Leu Leu Leu Val Ser Ala Gly Met Arg Thr Glu Asp Leu 
        115                 120                 125             


Pro Lys Ala Val Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu 
    130                 135                 140                 


Lys Asp Ser Val Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp 
145                 150                 155                 160 


Asn Ser Thr Gln Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala 
                165                 170                 175     


Ser Ser Tyr Phe Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr 
            180                 185                 190         


Arg Cys Gln Thr Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu 
        195                 200                 205             


Val His Ile Gly Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys 
    210                 215                 220                 


Glu Glu Asp Pro Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala 
225                 230                 235                 240 


Leu His Lys Val Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe 
                245                 250                 255     


His His Asn Ser Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser 
            260                 265                 270         


Gly Ser Tyr Phe Cys Arg Gly Leu Phe Gly Ser Lys Asn Val Ser Ser 
        275                 280                 285             


Glu Thr Val Asn Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile 
    290                 295                 300                 


Ser Ser Phe Phe Pro Pro Gly Tyr Gln Val Ser Phe Cys Leu Val Met 
305                 310                 315                 320 


Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr 
                325                 330                 335     


Asn Ile Arg Ser Ser Thr Arg Asp Trp Lys Asp His Lys Phe Lys Trp 
            340                 345                 350         


Arg Lys Asp Pro Gln Asp Lys 
        355                 


<210>  46
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hcOX40SF2IgG2sigma _HC cDNA

<400>  46
caggtgcagc tggtccagag cggagccgag gtgaagaagc ccggctccag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcaag gactacacca tgcactgggt gagacaggcc      120

cctggacagg gcctggaatg gatcggcggc atctacccca acaacggcgg ctccacctac      180

aaccagaact tcaaggacag ggtgaccctg accgccgaca agagcaccag caccgcttac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caggatgggc      300

taccacggcc ctcacctgga cttcgacgtg tggggccagg gcaccaccgt gacagtgagc      360

tccgcctcca ccaagggccc atcggtcttc cccctggcgc cctgctccag gagcacctcc      420

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgctct gaccagcggc gtgcacacct tcccagctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcaactt cggcacccag      600

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gacagttgag      660

cgcaaatgtt gtgtcgagtg cccaccgtgc ccagcaccac ctgccgcagc cagctcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcacg      780

tgcgtggtgg tggacgtgag cgccgaagac cccgaggtcc agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccacgggagg agcagttcaa cagcacgttc      900

cgtgtggtca gcgtcctcac cgttctgcac caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtct ccaacaaagg cctcccatcc tccatcgaga aaaccatctc caaaaccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cacctcccat gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210>  47
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OX40SF2_LC cDNA

<400>  47
gacatccaga tgacccagag ccctagcagc ctgagcgcta gcgtgggcga cagagtgacc       60

atcacctgca aggccagcca ggatgtggga gccgccgtgg cctggtatca gcagaagccc      120

ggaaaggccc ccaagctgct gatctactgg gccagcacca gacacaccgg cgtgcctagc      180

aggtttagcg gcagcggcag cggcaccgac tttaccctga ccatcagcag cctgcagccc      240

gaggatttcg ccacctacta ctgccagcag tacatcaact accccctgac cttcggcggc      300

ggcaccaaag tggagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  48
<211>  1692
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hcOX40SF2IgG2sigma _R2BS6_HC-C cDNA

<400>  48
caggtgcagc tggtccagag cggagccgag gtgaagaagc ccggctccag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcaag gactacacca tgcactgggt gagacaggcc      120

cctggacagg gcctggaatg gatcggcggc atctacccca acaacggcgg ctccacctac      180

aaccagaact tcaaggacag ggtgaccctg accgccgaca agagcaccag caccgcttac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caggatgggc      300

taccacggcc ctcacctgga cttcgacgtg tggggccagg gcaccaccgt gacagtgagc      360

tccgcctcca ccaagggccc atcggtcttc cccctggcgc cctgctccag gagcacctcc      420

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgctct gaccagcggc gtgcacacct tcccagctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcaactt cggcacccag      600

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gacagttgag      660

cgcaaatgtt gtgtcgagtg cccaccgtgc ccagcaccac ctgccgcagc cagctcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcacg      780

tgcgtggtgg tggacgtgag cgccgaagac cccgaggtcc agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccacgggagg agcagttcaa cagcacgttc      900

cgtgtggtca gcgtcctcac cgttctgcac caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtct ccaacaaagg cctcccatcc tccatcgaga aaaccatctc caaaaccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cacctcccat gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa aggaggcgga gggagtggcg ggggaggctc tggcggcgga     1380

ggatccggcg gcggaggaag cctgccggcg ccgaaaaacc tggttgtttc tcgtgttacc     1440

gaagactctg cgcgtctgtc ttggaccgcg ccggacgcgg cgttcgactc tttcctgatc     1500

cagtaccagg aatctgaaaa agttggtgaa gcgatcgtgc tgaccgttcc gggttctgaa     1560

cgttcttacg acctgaccgg tctgaaaccg ggtaccgaat acaccgtttc tatctacggt     1620

gttcaatatg cggcgtggta tctgccgcgt caccacgagg cgagcaaccc gctgtctgcg     1680

atcttcacca cc                                                         1692


<210>  49
<211>  1668
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hcOX40SF2IgG2sigma _R2BS9_HC-C cDNA

<400>  49
caggtgcagc tggtccagag cggagccgag gtgaagaagc ccggctccag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcaag gactacacca tgcactgggt gagacaggcc      120

cctggacagg gcctggaatg gatcggcggc atctacccca acaacggcgg ctccacctac      180

aaccagaact tcaaggacag ggtgaccctg accgccgaca agagcaccag caccgcttac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caggatgggc      300

taccacggcc ctcacctgga cttcgacgtg tggggccagg gcaccaccgt gacagtgagc      360

tccgcctcca ccaagggccc atcggtcttc cccctggcgc cctgctccag gagcacctcc      420

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgctct gaccagcggc gtgcacacct tcccagctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcaactt cggcacccag      600

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gacagttgag      660

cgcaaatgtt gtgtcgagtg cccaccgtgc ccagcaccac ctgccgcagc cagctcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcacg      780

tgcgtggtgg tggacgtgag cgccgaagac cccgaggtcc agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccacgggagg agcagttcaa cagcacgttc      900

cgtgtggtca gcgtcctcac cgttctgcac caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtct ccaacaaagg cctcccatcc tccatcgaga aaaccatctc caaaaccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cacctcccat gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa aggaggcgga gggagtggcg ggggaggctc tggcggcgga     1380

ggatccggcg gcggaggaag cctgccggcg ccgaaaaacc tggttgtttc tcgtgttacc     1440

gaagactctg cgcgtctgtc ttggaccgcg ccggacgcgg cgttcgactc tttctggatt     1500

tattacctgg agtattggcg tggcggtgaa gcgatcgttc tgaccgttcc gggttctgaa     1560

cgttcttacg acctgaccgg tctgaaaccg ggtaccgaat atttcgttca aattcacggc     1620

gttaagggcg gtcaatatag ttatccactg tctgcgatct tcaccacc                  1668


<210>  50
<211>  1668
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hcOX40SF2IgG2sigma _R2BS12_HC-C cDNA

<400>  50
caggtgcagc tggtccagag cggagccgag gtgaagaagc ccggctccag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcaag gactacacca tgcactgggt gagacaggcc      120

cctggacagg gcctggaatg gatcggcggc atctacccca acaacggcgg ctccacctac      180

aaccagaact tcaaggacag ggtgaccctg accgccgaca agagcaccag caccgcttac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caggatgggc      300

taccacggcc ctcacctgga cttcgacgtg tggggccagg gcaccaccgt gacagtgagc      360

tccgcctcca ccaagggccc atcggtcttc cccctggcgc cctgctccag gagcacctcc      420

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgctct gaccagcggc gtgcacacct tcccagctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcaactt cggcacccag      600

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gacagttgag      660

cgcaaatgtt gtgtcgagtg cccaccgtgc ccagcaccac ctgccgcagc cagctcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcacg      780

tgcgtggtgg tggacgtgag cgccgaagac cccgaggtcc agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccacgggagg agcagttcaa cagcacgttc      900

cgtgtggtca gcgtcctcac cgttctgcac caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtct ccaacaaagg cctcccatcc tccatcgaga aaaccatctc caaaaccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cacctcccat gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa aggaggcgga gggagtggcg ggggaggctc tggcggcgga     1380

ggatccggcg gcggaggaag cctgccggcg ccgaaaaacc tggttgtttc tcgtgttacc     1440

gaagactctg cgcgtctgtc ttggaccgcg ccggacgcgg cgttcgactc ttttctgatc     1500

gcgtatgcgg aatattggga gggcggtgaa gcggtcgttc tgaccgttcc gggttctgaa     1560

cgttcttacg acctgaccgg tctgaaaccg ggtaccgaat atttcgttca aatcaatggc     1620

gttaagggtg gtttctggag tatcccactg tctgcgatct tcaccacc                  1668


<210>  51
<211>  1668
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hcOX40SF2IgG2sigma _R2BS26_HC-C cDNA

<400>  51
caggtgcagc tggtccagag cggagccgag gtgaagaagc ccggctccag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcaag gactacacca tgcactgggt gagacaggcc      120

cctggacagg gcctggaatg gatcggcggc atctacccca acaacggcgg ctccacctac      180

aaccagaact tcaaggacag ggtgaccctg accgccgaca agagcaccag caccgcttac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caggatgggc      300

taccacggcc ctcacctgga cttcgacgtg tggggccagg gcaccaccgt gacagtgagc      360

tccgcctcca ccaagggccc atcggtcttc cccctggcgc cctgctccag gagcacctcc      420

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgctct gaccagcggc gtgcacacct tcccagctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcaactt cggcacccag      600

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gacagttgag      660

cgcaaatgtt gtgtcgagtg cccaccgtgc ccagcaccac ctgccgcagc cagctcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcacg      780

tgcgtggtgg tggacgtgag cgccgaagac cccgaggtcc agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccacgggagg agcagttcaa cagcacgttc      900

cgtgtggtca gcgtcctcac cgttctgcac caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtct ccaacaaagg cctcccatcc tccatcgaga aaaccatctc caaaaccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cacctcccat gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa aggaggcgga gggagtggcg ggggaggctc tggcggcgga     1380

ggatccggcg gcggaggaag cctgccggcg ccgaaaaacc tggttgtttc tcgtgttacc     1440

gaagactctg cgcgtctgtc ttggaccgcg ccggacgcgg cgttcgactc ttttccgatc     1500

gcgtatatcg agtattggac tggcggtgaa gcgatcgttc tgaccgttcc gggttctgaa     1560

cgttcttacg acctgaccgg tctgaaaccg ggtaccgaat atttcgtttg gattcacggc     1620

gttaagggtg gtgcgtggtc cagcccgctg tctgcgatct tcaccacc                  1668


<210>  52
<211>  1668
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hcOX40SF2IgG2sigma _R2BS29_HC-C cDNA

<400>  52
caggtgcagc tggtccagag cggagccgag gtgaagaagc ccggctccag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcaag gactacacca tgcactgggt gagacaggcc      120

cctggacagg gcctggaatg gatcggcggc atctacccca acaacggcgg ctccacctac      180

aaccagaact tcaaggacag ggtgaccctg accgccgaca agagcaccag caccgcttac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caggatgggc      300

taccacggcc ctcacctgga cttcgacgtg tggggccagg gcaccaccgt gacagtgagc      360

tccgcctcca ccaagggccc atcggtcttc cccctggcgc cctgctccag gagcacctcc      420

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgctct gaccagcggc gtgcacacct tcccagctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcaactt cggcacccag      600

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gacagttgag      660

cgcaaatgtt gtgtcgagtg cccaccgtgc ccagcaccac ctgccgcagc cagctcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcacg      780

tgcgtggtgg tggacgtgag cgccgaagac cccgaggtcc agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccacgggagg agcagttcaa cagcacgttc      900

cgtgtggtca gcgtcctcac cgttctgcac caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtct ccaacaaagg cctcccatcc tccatcgaga aaaccatctc caaaaccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cacctcccat gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa aggaggcgga gggagtggcg ggggaggctc tggcggcgga     1380

ggatccggcg gcggaggaag cctgcccgcc cccaagaacc tggtggtgag cagggtgacc     1440

gaggacagcg ccaggctgag ctggacagct cctgacgccg ccttcgacag cttccccatc     1500

tattactggg agtacagggt gggcggagag gccatcgtgc tgacagtgcc cggcagcgag     1560

aggagctacg acctgaccgg cctgaagcct ggcaccgagt acttcgtgta catcaacggc     1620

gtgaagggcg gcgaggaatc cagacccctg agcgccatct tcaccacc                  1668


<210>  53
<211>  1689
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hcOX40SF2IgG2sigma _R2BS39_HC-C cDNA

<400>  53
caggtgcagc tggtccagag cggagccgag gtgaagaagc ccggctccag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcaag gactacacca tgcactgggt gagacaggcc      120

cctggacagg gcctggaatg gatcggcggc atctacccca acaacggcgg ctccacctac      180

aaccagaact tcaaggacag ggtgaccctg accgccgaca agagcaccag caccgcttac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caggatgggc      300

taccacggcc ctcacctgga cttcgacgtg tggggccagg gcaccaccgt gacagtgagc      360

tccgcctcca ccaagggccc atcggtcttc cccctggcgc cctgctccag gagcacctcc      420

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgctct gaccagcggc gtgcacacct tcccagctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcaactt cggcacccag      600

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gacagttgag      660

cgcaaatgtt gtgtcgagtg cccaccgtgc ccagcaccac ctgccgcagc cagctcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcacg      780

tgcgtggtgg tggacgtgag cgccgaagac cccgaggtcc agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccacgggagg agcagttcaa cagcacgttc      900

cgtgtggtca gcgtcctcac cgttctgcac caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtct ccaacaaagg cctcccatcc tccatcgaga aaaccatctc caaaaccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cacctcccat gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa aggaggcgga gggagtggcg ggggaggctc tggcggcgga     1380

ggatccggcg gcggaggaag cctgccggcg ccgaaaaacc tggttgtttc tcgtgttacc     1440

gaagactctg cgcgtctgtc ttggaccgcg ccggacgcgg cgttcgactc tttcctgatc     1500

cagtaccagg aatctgaaaa agttggtgaa gcgatcgtgc tgaccgttcc gggttctgaa     1560

cgttcttacg acctgaccgg tctgaaaccg ggtaccgaat acaccgtttc tatctacggt     1620

gtgagccacg gcccgtggta taattatggc gagtggcgtt ctaacccgct gtctgcgatc     1680

ttcaccacc                                                             1689


<210>  54
<211>  1668
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hcOX40SF2IgG2sigma _R2BS56_HC-C cDNA

<400>  54
caggtgcagc tggtccagag cggagccgag gtgaagaagc ccggctccag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcaag gactacacca tgcactgggt gagacaggcc      120

cctggacagg gcctggaatg gatcggcggc atctacccca acaacggcgg ctccacctac      180

aaccagaact tcaaggacag ggtgaccctg accgccgaca agagcaccag caccgcttac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caggatgggc      300

taccacggcc ctcacctgga cttcgacgtg tggggccagg gcaccaccgt gacagtgagc      360

tccgcctcca ccaagggccc atcggtcttc cccctggcgc cctgctccag gagcacctcc      420

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgctct gaccagcggc gtgcacacct tcccagctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcaactt cggcacccag      600

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gacagttgag      660

cgcaaatgtt gtgtcgagtg cccaccgtgc ccagcaccac ctgccgcagc cagctcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcacg      780

tgcgtggtgg tggacgtgag cgccgaagac cccgaggtcc agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccacgggagg agcagttcaa cagcacgttc      900

cgtgtggtca gcgtcctcac cgttctgcac caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtct ccaacaaagg cctcccatcc tccatcgaga aaaccatctc caaaaccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cacctcccat gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa aggaggcgga gggagtggcg ggggaggctc tggcggcgga     1380

ggatccggcg gcggaggaag cctgccggcg ccgaaaaacc tggttgtttc tcgtgttacc     1440

gaagactctg cgcgtctgtc ttggaccgcg ccggacgcgg cgttcgactc ttttagcatt     1500

gcgtactggg agtatcgtaa aggcggtgaa gcgatcgttc tgaccgttcc gggttctgaa     1560

cgttcttacg acctgaccgg tctgaaaccg ggtaccgaat atttcgttct gatctatggt     1620

gtcaagggcg gttggcaatc caaaccactg tctgcgatct tcaccacc                  1668


<210>  55
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hcOX40SF2IgG1_HC

<400>  55
caggtgcagc tggtccagag cggagccgag gtgaagaagc ccggctccag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcaag gactacacca tgcactgggt gagacaggcc      120

cctggacagg gcctggaatg gatcggcggc atctacccca acaacggcgg ctccacctac      180

aaccagaact tcaaggacag ggtgaccctg accgccgaca agagcaccag caccgcttac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caggatgggc      300

taccacggcc ctcacctgga cttcgacgtg tggggccagg gcaccaccgt gacagtgagc      360

tccgcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1080

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  56
<211>  1668
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hcOX40SF2IgG2sigma_R2BS29_HC-N cDNA

<400>  56
ctgcccgccc ccaagaacct ggtcgtcagc agagtgaccg aggactccgc cagactgagc       60

tggacagccc ctgacgccgc cttcgattcc ttccccatct actactggga gtacagagtg      120

ggcggagagg ccatcgtgct gaccgtgcct ggctccgaga ggtcctacga cctgaccggc      180

ctgaagcctg gcaccgagta cttcgtgtac atcaacggcg tgaagggcgg agaggagtcc      240

agacccctga gcgccatttt caccacaggc ggcggcggct ccggcggagg cggctccggc      300

ggaggaggaa gcggcggcgg agggagccaa gtgcagctcg tgcagtccgg cgctgaggtg      360

aagaaacctg gctccagcgt caaggtgagc tgcaaggcca gcggctacac cttcaaggac      420

tacaccatgc actgggtgag gcaagcccct ggccaaggcc tggagtggat cggaggcatc      480

taccccaaca acggcggctc cacctataac cagaatttca aggacagggt gaccctgacc      540

gccgacaaga gcaccagcac cgcctacatg gagctgagca gcctgagatc cgaggacacc      600

gccgtgtact actgcgccag gatgggctat cacggccccc acctggactt tgacgtgtgg      660

ggccagggca caaccgtcac cgtgtccagc gcctccacca agggcccatc ggtcttcccc      720

ctggcgccct gctccaggag cacctccgag agcacagccg ccctgggctg cctggtcaag      780

gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgctctgac cagcggcgtg      840

cacaccttcc cagctgtcct acagtcctca ggactctact ccctcagcag cgtggtgacc      900

gtgccctcca gcaacttcgg cacccagacc tacacctgca acgtagatca caagcccagc      960

aacaccaagg tggacaagac agttgagcgc aaatgttgtg tcgagtgccc accgtgccca     1020

gcaccacctg ccgcagccag ctcagtcttc ctcttccccc caaaacccaa ggacaccctc     1080

atgatctccc ggacccctga ggtcacgtgc gtggtggtgg acgtgagcgc cgaagacccc     1140

gaggtccagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagcca     1200

cgggaggagc agttcaacag cacgttccgt gtggtcagcg tcctcaccgt tctgcaccag     1260

gactggctga acggcaagga gtacaagtgc aaggtctcca acaaaggcct cccatcctcc     1320

atcgagaaaa ccatctccaa aaccaaaggg cagccccgag aaccacaggt gtacaccctg     1380

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1440

ttctacccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1500

aagaccacac ctcccatgct ggactccgac ggctccttct tcctctacag caagctcacc     1560

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1620

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaa                  1668


<210>  57
<211>  969
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lcOX40SF2_R2BS29_LC-N cDNA

<400>  57
ctgcctgccc ccaagaacct ggtggtgagc agagtgaccg aggatagcgc cagactgtcc       60

tggacagccc ccgatgccgc cttcgactcc ttccccatct attactggga gtacagggtg      120

ggaggcgagg ccatcgtgct gaccgtgcct ggctccgaga ggagctacga tctgaccggc      180

ctgaagcccg gcaccgagta cttcgtgtac atcaacggcg tcaagggagg cgaggagagc      240

agacccctgt ccgccatctt caccacagga ggcggcggca gcggcggcgg aggcagcggc      300

ggcggaggct ccggcggcgg cggcagcgat atccagatga cccagagccc cagctccctg      360

tccgctagcg tgggcgacag agtgaccatc acctgcaagg ctagccagga cgtgggcgct      420

gctgtggcct ggtatcagca gaagcccggc aaggccccca agctgctgat ctactgggcc      480

tccacaaggc acaccggagt gcccagcaga ttttccggca gcggcagcgg caccgatttc      540

accctgacca tcagctccct gcagcccgag gacttcgcca cctactactg ccagcagtac      600

atcaattacc ccctgacctt cggcggaggc accaaggtgg agatcaaacg tacggtggct      660

gcaccatctg tcttcatctt cccgccatct gatgagcagt tgaaatctgg aactgcctct      720

gttgtgtgcc tgctgaataa cttctatccc agagaggcca aagtacagtg gaaggtggat      780

aacgccctcc aatcgggtaa ctcccaggag agtgtcacag agcaggacag caaggacagc      840

acctacagcc tcagcagcac cctgacgctg agcaaagcag actacgagaa acacaaagtc      900

tacgcctgcg aagtcaccca tcagggcctg agctcgcccg tcacaaagag cttcaacagg      960

ggagagtgt                                                              969


<210>  58
<211>  972
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lcOX40SF2_R2BS29_LC-C  cDNA

<400>  58
gacatccaga tgacccagag ccccagcagc ctgtctgcca gcgtgggcga cagagtgacc       60

atcacatgca aggccagcca ggacgtggga gccgccgtgg cttggtatca gcagaagcct      120

ggcaaggccc ccaagctgct gatctactgg gccagcacca gacacaccgg cgtgcccagc      180

agattttctg gcagcggctc cggcaccgac ttcaccctga caatcagctc cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag tacatcaact accccctgac cttcggcgga      300

ggcaccaagg tggaaatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gtggcggcgg cggcagcggc      660

ggcggcggca gcggcggcgg cggcagcggc ggaggaggat ccatgctgcc tgcccccaag      720

aacctggtgg tgagcagggt gaccgaggac agcgccagac tgagctggac agctcccgac      780

gccgccttcg actccttccc catctactac tgggagtaca gagtgggcgg cgaagccatt      840

gtgctgaccg tgcccggcag cgagaggagc tacgacctga ccggcctgaa gcccggcacc      900

gagtacttcg tgtacatcaa cggcgtgaag ggcggcgaag agagcaggcc tctgagcgcc      960

atcttcacca ca                                                          972


<210>  59
<211>  1680
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hcOX40SF2IgG1 _R2BS29_HC-C  cDNA

<400>  59
caggtgcagc tggtccagag cggagccgag gtgaagaagc ccggctccag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcaag gactacacca tgcactgggt gagacaggcc      120

cctggacagg gcctggaatg gatcggcggc atctacccca acaacggcgg ctccacctac      180

aaccagaact tcaaggacag ggtgaccctg accgccgaca agagcaccag caccgcttac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caggatgggc      300

taccacggcc ctcacctgga cttcgacgtg tggggccagg gcaccaccgt gacagtgagc      360

tccgcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1080

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaaggaggcg gagggagtgg cgggggaggc     1380

tctggcggcg gaggatccgg cggcggagga agcctgcccg cccccaagaa cctggtggtg     1440

agcagggtga ccgaggacag cgccaggctg agctggacag ctcctgacgc cgccttcgac     1500

agcttcccca tctattactg ggagtacagg gtgggcggag aggccatcgt gctgacagtg     1560

cccggcagcg agaggagcta cgacctgacc ggcctgaagc ctggcaccga gtacttcgtg     1620

tacatcaacg gcgtgaaggg cggcgaggaa tccagacccc tgagcgccat cttcaccacc     1680


