                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  Methods For Modulating The Interaction Between EWS-FLI1 And BAF 
       Complexes

<130>  DFS-199.25

<140>  PCT/US2018/000339
<141>  2018-08-20

<150>  US 62/548,334
<151>  2017-08-21

<150>  US 62/550,103
<151>  2017-08-25

<160>  76    

<170>  PatentIn version 3.5

<210>  1
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ser Thr Asp Tyr Ser Thr Tyr Ser Gln Ala Ala Ala Gln Gln 
1               5                   10                  15      


Gly Tyr Ser Ala Tyr Thr Ala Gln Pro Thr Gln Gly Tyr Ala Gln Thr 
            20                  25                  30          


Thr Gln Ala Tyr Gly Gln Gln Ser Tyr Gly Thr Tyr Gly Gln Pro Thr 
        35                  40                  45              


Asp Val Ser Tyr Thr Gln Ala Gln Thr Thr Ala Thr Tyr Gly Gln Thr 
    50                  55                  60                  


Ala Tyr Ala Thr Ser Tyr Gly Gln Pro Pro Thr Gly Tyr Thr Thr Pro 
65                  70                  75                  80  


Thr Ala Pro Gln Ala Tyr Ser Gln Pro Val Gln Gly Tyr Gly Thr Gly 
                85                  90                  95      


Ala Tyr Asp Thr Thr Thr Ala Thr Val Thr Thr Thr Gln Ala Ser Tyr 
            100                 105                 110         


Ala Ala Gln Ser Ala Tyr Gly Thr Gln Pro Ala Tyr Pro Ala Tyr Gly 
        115                 120                 125             


Gln Gln Pro Ala Ala Thr Ala Pro Thr Arg Pro Gln Asp Gly Asn Lys 
    130                 135                 140                 


Pro Thr Glu Thr Ser Gln Pro Gln Ser Ser Thr Gly Gly Tyr Asn Gln 
145                 150                 155                 160 


Pro Ser Leu Gly Tyr Gly Gln Ser Asn Tyr Ser Tyr Pro Gln Val Pro 
                165                 170                 175     


Gly Ser Tyr Pro Met Gln Pro Val Thr Ala Pro Pro Ser Tyr Pro Pro 
            180                 185                 190         


Thr Ser Tyr Ser Ser Thr Gln Pro Thr Ser Tyr Asp Gln Ser Ser Tyr 
        195                 200                 205             


Ser Gln Gln Asn Thr Tyr Gly Gln Pro Ser Ser Tyr Gly Gln Gln Ser 
    210                 215                 220                 


Ser Tyr Gly Gln Gln Ser Ser Tyr Gly Gln Gln Pro Pro Thr Ser Tyr 
225                 230                 235                 240 


Pro Pro Gln Thr Gly Ser Tyr Ser Gln Ala Pro Ser Gln Tyr Ser Gln 
                245                 250                 255     


Gln Ser Ser Ser Tyr Gly Gln Gln Asn Pro Ser Tyr Asp Ser Val Arg 
            260                 265                 270         


Arg Gly Ala Trp Gly Asn Asn Met Asn Ser Gly Leu Asn Lys Ser Pro 
        275                 280                 285             


Pro Leu Gly Gly Ala Gln Thr Ile Ser Lys Asn Thr Glu Gln Arg Pro 
    290                 295                 300                 


Gln Pro Asp Pro Tyr Gln Ile Leu Gly Pro Thr Ser Ser Arg Leu Ala 
305                 310                 315                 320 


Asn Pro Gly Ser Gly Gln Ile Gln Leu Trp Gln Phe Leu Leu Glu Leu 
                325                 330                 335     


Leu Ser Asp Ser Ala Asn Ala Ser Cys Ile Thr Trp Glu Gly Thr Asn 
            340                 345                 350         


Gly Glu Phe Lys Met Thr Asp Pro Asp Glu Val Ala Arg Arg Trp Gly 
        355                 360                 365             


Glu Arg Lys Ser Lys Pro Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala 
    370                 375                 380                 


Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile Met Thr Lys Val His Gly Lys 
385                 390                 395                 400 


Arg Tyr Ala Tyr Lys Phe Asp Phe His Gly Ile Ala Gln Ala Leu Gln 
                405                 410                 415     


Pro His Pro Thr Glu Ser Ser Met Tyr Lys Tyr Pro Ser Asp Ile Ser 
            420                 425                 430         


Tyr Met Pro Ser Tyr His Ala His Gln Gln Lys Val Asn Phe Val Pro 
        435                 440                 445             


Pro His Pro Ser Ser Met Pro Val Thr Ser Ser Ser Phe Phe Gly Ala 
    450                 455                 460                 


Ala Ser Gln Tyr Trp Thr Ser Pro Thr Gly Gly Ile Tyr Pro Asn Pro 
465                 470                 475                 480 


Asn Val Pro Arg His Pro Asn Thr His Val Pro Ser His Leu Gly Ser 
                485                 490                 495     


Tyr Tyr 
        


<210>  2
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ser Thr Asp Tyr Ser Thr Tyr Ser Gln Ala Ala Ala Gln Gln 
1               5                   10                  15      


Gly Tyr Ser Ala Tyr Thr Ala Gln Pro Thr Gln Gly Tyr Ala Gln Thr 
            20                  25                  30          


Thr Gln Ala Tyr Gly Gln Gln Ser Tyr Gly Thr Tyr Gly Gln Pro Thr 
        35                  40                  45              


Asp Val Ser Tyr Thr Gln Ala Gln Thr Thr Ala Thr Tyr Gly Gln Thr 
    50                  55                  60                  


Ala Tyr Ala Thr Ser Tyr Gly Gln Pro Pro Thr Gly Tyr Thr Thr Pro 
65                  70                  75                  80  


Thr Ala Pro Gln Ala Tyr Ser Gln Pro Val Gln Gly Tyr Gly Thr Gly 
                85                  90                  95      


Ala Tyr Asp Thr Thr Thr Ala Thr Val Thr Thr Thr Gln Ala Ser Tyr 
            100                 105                 110         


Ala Ala Gln Ser Ala Tyr Gly Thr Gln Pro Ala Tyr Pro Ala Tyr Gly 
        115                 120                 125             


Gln Gln Pro Ala Ala Thr Ala Pro Thr Arg Pro Gln Asp Gly Asn Lys 
    130                 135                 140                 


Pro Thr Glu Thr Ser Gln Pro Gln Ser Ser Thr Gly Gly Tyr Asn Gln 
145                 150                 155                 160 


Pro Ser Leu Gly Tyr Gly Gln Ser Asn Tyr Ser Tyr Pro Gln Val Pro 
                165                 170                 175     


Gly Ser Tyr Pro Met Gln Pro Val Thr Ala Pro Pro Ser Tyr Pro Pro 
            180                 185                 190         


Thr Ser Tyr Ser Ser Thr Gln Pro Thr Ser Tyr Asp Gln Ser Ser Tyr 
        195                 200                 205             


Ser Gln Gln Asn Thr Tyr Gly Gln Pro Ser Ser Tyr Gly Gln Gln Ser 
    210                 215                 220                 


Ser Tyr Gly Gln Gln Ser Ser Tyr Gly Gln Gln Pro Pro Thr Ser Tyr 
225                 230                 235                 240 


Pro Pro Gln Thr Gly Ser Tyr Ser Gln Ala Pro Ser Gln Tyr Ser Gln 
                245                 250                 255     


Gln Ser Ser Ser Tyr Gly Gln Gln Ser Ser Leu Leu Ala Tyr Asn Thr 
            260                 265                 270         


Thr Ser His Thr Asp Gln Ser Ser Arg Leu Ser Val Lys Glu Asp Pro 
        275                 280                 285             


Ser Tyr Asp Ser Val Arg Arg Gly Ala Trp Gly Asn Asn Met Asn Ser 
    290                 295                 300                 


Gly Leu Asn Lys Ser Pro Pro Leu Gly Gly Ala Gln Thr Ile Ser Lys 
305                 310                 315                 320 


Asn Thr Glu Gln Arg Pro Gln Pro Asp Pro Tyr Gln Ile Leu Gly Pro 
                325                 330                 335     


Thr Ser Ser Arg Leu Ala Asn Pro Gly Ser Gly Gln Ile Gln Leu Trp 
            340                 345                 350         


Gln Phe Leu Leu Glu Leu Leu Ser Asp Ser Ala Asn Ala Ser Cys Ile 
        355                 360                 365             


Thr Trp Glu Gly Thr Asn Gly Glu Phe Lys Met Thr Asp Pro Asp Glu 
    370                 375                 380                 


Val Ala Arg Arg Trp Gly Glu Arg Lys Ser Lys Pro Asn Met Asn Tyr 
385                 390                 395                 400 


Asp Lys Leu Ser Arg Ala Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile Met 
                405                 410                 415     


Thr Lys Val His Gly Lys Arg Tyr Ala Tyr Lys Phe Asp Phe His Gly 
            420                 425                 430         


Ile Ala Gln Ala Leu Gln Pro His Pro Thr Glu Ser Ser Met Tyr Lys 
        435                 440                 445             


Tyr Pro Ser Asp Ile Ser Tyr Met Pro Ser Tyr His Ala His Gln Gln 
    450                 455                 460                 


Lys Val Asn Phe Val Pro Pro His Pro Ser Ser Met Pro Val Thr Ser 
465                 470                 475                 480 


Ser Ser Phe Phe Gly Ala Ala Ser Gln Tyr Trp Thr Ser Pro Thr Gly 
                485                 490                 495     


Gly Ile Tyr Pro Asn Pro Asn Val Pro Arg His Pro Asn Thr His Val 
            500                 505                 510         


Pro Ser His Leu Gly Ser Tyr Tyr 
        515                 520 


<210>  3
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Ser Thr Asp Tyr Ser Thr Tyr Ser Gln Ala Ala Ala Gln Gln 
1               5                   10                  15      


Gly Tyr Ser Ala Tyr Thr Ala Gln Pro Thr Gln Gly Tyr Ala Gln Thr 
            20                  25                  30          


Thr Gln Ala Tyr Gly Gln Gln Ser Tyr Gly Thr Tyr Gly Gln Pro Thr 
        35                  40                  45              


Asp Val Ser Tyr Thr Gln Ala Gln Thr Thr Ala Thr Tyr Gly Gln Thr 
    50                  55                  60                  


Ala Tyr Ala Thr Ser Tyr Gly Gln Pro Pro Thr Gly Tyr Thr Thr Pro 
65                  70                  75                  80  


Thr Ala Pro Gln Ala Tyr Ser Gln Pro Val Gln Gly Tyr Gly Thr Gly 
                85                  90                  95      


Ala Tyr Asp Thr Thr Thr Ala Thr Val Thr Thr Thr Gln Ala Ser Tyr 
            100                 105                 110         


Ala Ala Gln Ser Ala Tyr Gly Thr Gln Pro Ala Tyr Pro Ala Tyr Gly 
        115                 120                 125             


Gln Gln Pro Ala Ala Thr Ala Pro Thr Arg Pro Gln Asp Gly Asn Lys 
    130                 135                 140                 


Pro Thr Glu Thr Ser Gln Pro Gln Ser Ser Thr Gly Gly Tyr Asn Gln 
145                 150                 155                 160 


Pro Ser Leu Gly Tyr Gly Gln Ser Asn Tyr Ser Tyr Pro Gln Val Pro 
                165                 170                 175     


Gly Ser Tyr Pro Met Gln Pro Val Thr Ala Pro Pro Ser Tyr Pro Pro 
            180                 185                 190         


Thr Ser Tyr Ser Ser Thr Gln Pro Thr Ser Tyr Asp Gln Ser Ser Tyr 
        195                 200                 205             


Ser Gln Gln Asn Thr Tyr Gly Gln Pro Ser Ser Tyr Gly Gln Gln Ser 
    210                 215                 220                 


Ser Tyr Gly Gln Gln Ser Ser Tyr Gly Gln Gln Pro Pro Thr Ser Tyr 
225                 230                 235                 240 


Pro Pro Gln Thr Gly Ser Tyr Ser Gln Ala Pro Ser Gln Tyr Ser Gln 
                245                 250                 255     


Gln Ser Ser Ser Tyr Gly Gln Gln 
            260                 


<210>  4
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  4

Pro Ser Tyr Asp Ser Val Arg Arg Gly Ala Trp Gly Asn Asn Met Asn 
1               5                   10                  15      


Ser Gly Leu Asn Lys Ser Pro Pro Leu Gly Gly Ala Gln Thr Ile Ser 
            20                  25                  30          


Lys Asn Thr Glu Gln Arg Pro Gln Pro Asp Pro Tyr Gln Ile Leu Gly 
        35                  40                  45              


Pro Thr Ser Ser Arg Leu Ala Asn Pro Gly Ser Gly Gln Ile Gln Leu 
    50                  55                  60                  


Trp Gln Phe Leu Leu Glu Leu Leu Ser Asp Ser Ala Asn Ala Ser Cys 
65                  70                  75                  80  


Ile Thr Trp Glu Gly Thr Asn Gly Glu Phe Lys Met Thr Asp Pro Asp 
                85                  90                  95      


Glu Val Ala Arg Arg Trp Gly Glu Arg Lys Ser Lys Pro Asn Met Asn 
            100                 105                 110         


Tyr Asp Lys Leu Ser Arg Ala Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile 
        115                 120                 125             


Met Thr Lys Val His Gly Lys Arg Tyr Ala Tyr Lys Phe Asp Phe His 
    130                 135                 140                 


Gly Ile Ala Gln Ala Leu Gln Pro His Pro Thr Glu Ser Ser Met Tyr 
145                 150                 155                 160 


Lys Tyr Pro Ser Asp Ile Ser Tyr Met Pro Ser Tyr His Ala His Gln 
                165                 170                 175     


Gln Lys Val Asn Phe Val Pro Pro His Pro Ser Ser Met Pro Val Thr 
            180                 185                 190         


Ser Ser Ser Phe Phe Gly Ala Ala Ser Gln Tyr Trp Thr Ser Pro Thr 
        195                 200                 205             


Gly Gly Ile Tyr Pro Asn Pro Asn Val Pro Arg His Pro Asn Thr His 
    210                 215                 220                 


Val Pro Ser His Leu Gly Ser Tyr Tyr 
225                 230             


<210>  5
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Ser Thr Asp Tyr Ser Thr Tyr Ser Gln Ala Ala Ala Gln Gln 
1               5                   10                  15      


Gly Ser Ser Ala Tyr Thr Ala Gln Pro Thr Gln Gly Tyr Ala Gln Thr 
            20                  25                  30          


Thr Gln Ala Tyr Gly Gln Gln Ser Ser Gly Thr Tyr Gly Gln Pro Thr 
        35                  40                  45              


Asp Val Ser Tyr Thr Gln Ala Gln Thr Thr Ala Thr Tyr Gly Gln Thr 
    50                  55                  60                  


Ala Tyr Ala Thr Ser Ser Gly Gln Pro Pro Thr Gly Tyr Thr Thr Pro 
65                  70                  75                  80  


Thr Ala Pro Gln Ala Tyr Ser Gln Pro Val Gln Gly Ser Gly Thr Gly 
                85                  90                  95      


Ala Tyr Asp Thr Thr Thr Ala Thr Val Thr Thr Thr Gln Ala Ser Tyr 
            100                 105                 110         


Ala Ala Gln Ser Ala Tyr Gly Thr Gln Pro Ala Tyr Pro Ala Tyr Gly 
        115                 120                 125             


Gln Gln Pro Ala Ala Thr Ala Pro Thr Arg Pro Gln Asp Gly Asn Lys 
    130                 135                 140                 


Pro Thr Glu Thr Ser Gln Pro Gln Ser Ser Thr Gly Gly Tyr Asn Gln 
145                 150                 155                 160 


Pro Ser Leu Gly Ser Gly Gln Ser Asn Tyr Ser Tyr Pro Gln Val Pro 
                165                 170                 175     


Gly Ser Tyr Pro Met Gln Pro Val Thr Ala Pro Pro Ser Tyr Pro Pro 
            180                 185                 190         


Thr Ser Ser Ser Ser Thr Gln Pro Thr Ser Tyr Asp Gln Ser Ser Ser 
        195                 200                 205             


Ser Gln Gln Asn Thr Tyr Gly Gln Pro Ser Ser Ser Gly Gln Gln Ser 
    210                 215                 220                 


Ser Ser Gly Gln Gln Ser Ser Ser Gly Gln Gln Pro Pro Thr Ser Tyr 
225                 230                 235                 240 


Pro Pro Gln Thr Gly Ser Ser Ser Gln Ala Pro Ser Gln Tyr Ser Gln 
                245                 250                 255     


Gln Ser Ser Ser Ser Gly Gln Gln Asn Pro Ser Tyr Asp Ser Val Arg 
            260                 265                 270         


Arg Gly Ala Trp Gly Asn Asn Met Asn Ser Gly Leu Asn Lys Ser Pro 
        275                 280                 285             


Pro Leu Gly Gly Ala Gln Thr Ile Ser Lys Asn Thr Glu Gln Arg Pro 
    290                 295                 300                 


Gln Pro Asp Pro Tyr Gln Ile Leu Gly Pro Thr Ser Ser Arg Leu Ala 
305                 310                 315                 320 


Asn Pro Gly Ser Gly Gln Ile Gln Leu Trp Gln Phe Leu Leu Glu Leu 
                325                 330                 335     


Leu Ser Asp Ser Ala Asn Ala Ser Cys Ile Thr Trp Glu Gly Thr Asn 
            340                 345                 350         


Gly Glu Phe Lys Met Thr Asp Pro Asp Glu Val Ala Arg Arg Trp Gly 
        355                 360                 365             


Glu Arg Lys Ser Lys Pro Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala 
    370                 375                 380                 


Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile Met Thr Lys Val His Gly Lys 
385                 390                 395                 400 


Arg Tyr Ala Tyr Lys Phe Asp Phe His Gly Ile Ala Gln Ala Leu Gln 
                405                 410                 415     


Pro His Pro Thr Glu Ser Ser Met Tyr Lys Tyr Pro Ser Asp Ile Ser 
            420                 425                 430         


Tyr Met Pro Ser Tyr His Ala His Gln Gln Lys Val Asn Phe Val Pro 
        435                 440                 445             


Pro His Pro Ser Ser Met Pro Val Thr Ser Ser Ser Phe Phe Gly Ala 
    450                 455                 460                 


Ala Ser Gln Tyr Trp Thr Ser Pro Thr Gly Gly Ile Tyr Pro Asn Pro 
465                 470                 475                 480 


Asn Val Pro Arg His Pro Asn Thr His Val Pro Ser His Leu Gly Ser 
                485                 490                 495     


Tyr Tyr 
        


<210>  6
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ser Thr Asp Ser Ser Thr Ser Ser Gln Ala Ala Ala Gln Gln 
1               5                   10                  15      


Gly Ser Ser Ala Ser Thr Ala Gln Pro Thr Gln Gly Ser Ala Gln Thr 
            20                  25                  30          


Thr Gln Ala Ser Gly Gln Gln Ser Ser Gly Thr Ser Gly Gln Pro Thr 
        35                  40                  45              


Asp Val Ser Ser Thr Gln Ala Gln Thr Thr Ala Thr Ser Gly Gln Thr 
    50                  55                  60                  


Ala Ser Ala Thr Ser Ser Gly Gln Pro Pro Thr Gly Ser Thr Thr Pro 
65                  70                  75                  80  


Thr Ala Pro Gln Ala Ser Ser Gln Pro Val Gln Gly Ser Gly Thr Gly 
                85                  90                  95      


Ala Ser Asp Thr Thr Thr Ala Thr Val Thr Thr Thr Gln Ala Ser Ser 
            100                 105                 110         


Ala Ala Gln Ser Ala Ser Gly Thr Gln Pro Ala Ser Pro Ala Ser Gly 
        115                 120                 125             


Gln Gln Pro Ala Ala Thr Ala Pro Thr Arg Pro Gln Asp Gly Asn Lys 
    130                 135                 140                 


Pro Thr Glu Thr Ser Gln Pro Gln Ser Ser Thr Gly Gly Ser Asn Gln 
145                 150                 155                 160 


Pro Ser Leu Gly Ser Gly Gln Ser Asn Ser Ser Ser Pro Gln Val Pro 
                165                 170                 175     


Gly Ser Ser Pro Met Gln Pro Val Thr Ala Pro Pro Ser Ser Pro Pro 
            180                 185                 190         


Thr Ser Ser Ser Ser Thr Gln Pro Thr Ser Ser Asp Gln Ser Ser Ser 
        195                 200                 205             


Ser Gln Gln Asn Thr Ser Gly Gln Pro Ser Ser Ser Gly Gln Gln Ser 
    210                 215                 220                 


Ser Ser Gly Gln Gln Ser Ser Ser Gly Gln Gln Pro Pro Thr Ser Ser 
225                 230                 235                 240 


Pro Pro Gln Thr Gly Ser Ser Ser Gln Ala Pro Ser Gln Ser Ser Gln 
                245                 250                 255     


Gln Ser Ser Ser Ser Gly Gln Gln Asn Pro Ser Tyr Asp Ser Val Arg 
            260                 265                 270         


Arg Gly Ala Trp Gly Asn Asn Met Asn Ser Gly Leu Asn Lys Ser Pro 
        275                 280                 285             


Pro Leu Gly Gly Ala Gln Thr Ile Ser Lys Asn Thr Glu Gln Arg Pro 
    290                 295                 300                 


Gln Pro Asp Pro Tyr Gln Ile Leu Gly Pro Thr Ser Ser Arg Leu Ala 
305                 310                 315                 320 


Asn Pro Gly Ser Gly Gln Ile Gln Leu Trp Gln Phe Leu Leu Glu Leu 
                325                 330                 335     


Leu Ser Asp Ser Ala Asn Ala Ser Cys Ile Thr Trp Glu Gly Thr Asn 
            340                 345                 350         


Gly Glu Phe Lys Met Thr Asp Pro Asp Glu Val Ala Arg Arg Trp Gly 
        355                 360                 365             


Glu Arg Lys Ser Lys Pro Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala 
    370                 375                 380                 


Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile Met Thr Lys Val His Gly Lys 
385                 390                 395                 400 


Arg Tyr Ala Tyr Lys Phe Asp Phe His Gly Ile Ala Gln Ala Leu Gln 
                405                 410                 415     


Pro His Pro Thr Glu Ser Ser Met Tyr Lys Tyr Pro Ser Asp Ile Ser 
            420                 425                 430         


Tyr Met Pro Ser Tyr His Ala His Gln Gln Lys Val Asn Phe Val Pro 
        435                 440                 445             


Pro His Pro Ser Ser Met Pro Val Thr Ser Ser Ser Phe Phe Gly Ala 
    450                 455                 460                 


Ala Ser Gln Tyr Trp Thr Ser Pro Thr Gly Gly Ile Tyr Pro Asn Pro 
465                 470                 475                 480 


Asn Val Pro Arg His Pro Asn Thr His Val Pro Ser His Leu Gly Ser 
                485                 490                 495     


Tyr Tyr 
        


<210>  7
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  7

Tyr Gly Gln Gln Ser Tyr Gly Thr Tyr Gly Gln Pro Thr Asp Val Ser 
1               5                   10                  15      


Tyr Thr Gln Ala Gln Thr Thr Ala Thr Tyr Gly Gln Thr Ala Tyr Ala 
            20                  25                  30          


Thr Ser Tyr Gly Gln Asn Pro Ser Tyr Asp Ser Val Arg Arg Gly Ala 
        35                  40                  45              


Trp Gly Asn Asn Met Asn Ser Gly Leu Asn Lys Ser Pro Pro Leu Gly 
    50                  55                  60                  


Gly Ala Gln Thr Ile Ser Lys Asn Thr Glu Gln Arg Pro Gln Pro Asp 
65                  70                  75                  80  


Pro Tyr Gln Ile Leu Gly Pro Thr Ser Ser Arg Leu Ala Asn Pro Gly 
                85                  90                  95      


Ser Gly Gln Ile Gln Leu Trp Gln Phe Leu Leu Glu Leu Leu Ser Asp 
            100                 105                 110         


Ser Ala Asn Ala Ser Cys Ile Thr Trp Glu Gly Thr Asn Gly Glu Phe 
        115                 120                 125             


Lys Met Thr Asp Pro Asp Glu Val Ala Arg Arg Trp Gly Glu Arg Lys 
    130                 135                 140                 


Ser Lys Pro Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu Arg Tyr 
145                 150                 155                 160 


Tyr Tyr Asp Lys Asn Ile Met Thr Lys Val His Gly Lys Arg Tyr Ala 
                165                 170                 175     


Tyr Lys Phe Asp Phe His Gly Ile Ala Gln Ala Leu Gln Pro His Pro 
            180                 185                 190         


Thr Glu Ser Ser Met Tyr Lys Tyr Pro Ser Asp Ile Ser Tyr Met Pro 
        195                 200                 205             


Ser Tyr His Ala His Gln Gln Lys Val Asn Phe Val Pro Pro His Pro 
    210                 215                 220                 


Ser Ser Met Pro Val Thr Ser Ser Ser Phe Phe Gly Ala Ala Ser Gln 
225                 230                 235                 240 


Tyr Trp Thr Ser Pro Thr Gly Gly Ile Tyr Pro Asn Pro Asn Val Pro 
                245                 250                 255     


Arg His Pro Asn Thr His Val Pro Ser His Leu Gly Ser Tyr Tyr 
            260                 265                 270     


<210>  8
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  8

Thr Ser Tyr Asp Gln Ser Ser Tyr Ser Gln Gln Asn Thr Tyr Gly Gln 
1               5                   10                  15      


Pro Ser Ser Tyr Gly Gln Gln Ser Ser Tyr Gly Gln Gln Ser Ser Tyr 
            20                  25                  30          


Gly Gln Gln Pro Pro Thr Ser Tyr Pro Pro Gln Thr Gly Ser Tyr Ser 
        35                  40                  45              


Gln Ala Pro Ser Gln Tyr Ser Gln Gln Ser Ser Ser Tyr Gly Gln Gln 
    50                  55                  60                  


Asn Pro Ser Tyr Asp Ser Val Arg Arg Gly Ala Trp Gly Asn Asn Met 
65                  70                  75                  80  


Asn Ser Gly Leu Asn Lys Ser Pro Pro Leu Gly Gly Ala Gln Thr Ile 
                85                  90                  95      


Ser Lys Asn Thr Glu Gln Arg Pro Gln Pro Asp Pro Tyr Gln Ile Leu 
            100                 105                 110         


Gly Pro Thr Ser Ser Arg Leu Ala Asn Pro Gly Ser Gly Gln Ile Gln 
        115                 120                 125             


Leu Trp Gln Phe Leu Leu Glu Leu Leu Ser Asp Ser Ala Asn Ala Ser 
    130                 135                 140                 


Cys Ile Thr Trp Glu Gly Thr Asn Gly Glu Phe Lys Met Thr Asp Pro 
145                 150                 155                 160 


Asp Glu Val Ala Arg Arg Trp Gly Glu Arg Lys Ser Lys Pro Asn Met 
                165                 170                 175     


Asn Tyr Asp Lys Leu Ser Arg Ala Leu Arg Tyr Tyr Tyr Asp Lys Asn 
            180                 185                 190         


Ile Met Thr Lys Val His Gly Lys Arg Tyr Ala Tyr Lys Phe Asp Phe 
        195                 200                 205             


His Gly Ile Ala Gln Ala Leu Gln Pro His Pro Thr Glu Ser Ser Met 
    210                 215                 220                 


Tyr Lys Tyr Pro Ser Asp Ile Ser Tyr Met Pro Ser Tyr His Ala His 
225                 230                 235                 240 


Gln Gln Lys Val Asn Phe Val Pro Pro His Pro Ser Ser Met Pro Val 
                245                 250                 255     


Thr Ser Ser Ser Phe Phe Gly Ala Ala Ser Gln Tyr Trp Thr Ser Pro 
            260                 265                 270         


Thr Gly Gly Ile Tyr Pro Asn Pro Asn Val Pro Arg His Pro Asn Thr 
        275                 280                 285             


His Val Pro Ser His Leu Gly Ser Tyr Tyr 
    290                 295             


<210>  9
<211>  623
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Met Met Met Ala Leu Ser Lys Thr Phe Gly Gln Lys Pro Val Lys 
1               5                   10                  15      


Phe Gln Leu Glu Asp Asp Gly Glu Phe Tyr Met Ile Gly Ser Glu Val 
            20                  25                  30          


Gly Asn Tyr Leu Arg Met Phe Arg Gly Ser Leu Tyr Lys Arg Tyr Pro 
        35                  40                  45              


Ser Leu Trp Arg Arg Leu Ala Thr Val Glu Glu Arg Lys Lys Ile Val 
    50                  55                  60                  


Ala Ser Ser His Asp His Gly Tyr Thr Thr Leu Ala Thr Ser Val Thr 
65                  70                  75                  80  


Leu Leu Lys Ala Ser Glu Val Glu Glu Ile Leu Asp Gly Asn Asp Glu 
                85                  90                  95      


Lys Tyr Lys Ala Val Ser Ile Ser Thr Glu Pro Pro Thr Tyr Leu Arg 
            100                 105                 110         


Glu Gln Lys Ala Lys Arg Asn Ser Gln Trp Val Pro Thr Leu Pro Asn 
        115                 120                 125             


Ser Ser His His Leu Asp Ala Val Pro Cys Ser Thr Thr Ile Asn Arg 
    130                 135                 140                 


Asn Arg Met Gly Arg Asp Lys Lys Arg Thr Phe Pro Leu Cys Phe Asp 
145                 150                 155                 160 


Asp His Asp Pro Ala Val Ile His Glu Asn Ala Ser Gln Pro Glu Val 
                165                 170                 175     


Leu Val Pro Ile Arg Leu Asp Met Glu Ile Asp Gly Gln Lys Leu Arg 
            180                 185                 190         


Asp Ala Phe Thr Trp Asn Met Asn Glu Lys Leu Met Thr Pro Glu Met 
        195                 200                 205             


Phe Ser Glu Ile Leu Cys Asp Asp Leu Asp Leu Asn Pro Leu Thr Phe 
    210                 215                 220                 


Val Pro Ala Ile Ala Ser Ala Ile Arg Gln Gln Ile Glu Ser Tyr Pro 
225                 230                 235                 240 


Thr Asp Ser Ile Leu Glu Asp Gln Ser Asp Gln Arg Val Ile Ile Lys 
                245                 250                 255     


Leu Asn Ile His Val Gly Asn Ile Ser Leu Val Asp Gln Phe Glu Trp 
            260                 265                 270         


Asp Met Ser Glu Lys Glu Asn Ser Pro Glu Lys Phe Ala Leu Lys Leu 
        275                 280                 285             


Cys Ser Glu Leu Gly Leu Gly Gly Glu Phe Val Thr Thr Ile Ala Tyr 
    290                 295                 300                 


Ser Ile Arg Gly Gln Leu Ser Trp His Gln Lys Thr Tyr Ala Phe Ser 
305                 310                 315                 320 


Glu Asn Pro Leu Pro Thr Val Glu Ile Ala Ile Arg Asn Thr Gly Asp 
                325                 330                 335     


Ala Asp Gln Trp Cys Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met 
            340                 345                 350         


Glu Lys Lys Ile Arg Asp Gln Asp Arg Asn Thr Arg Arg Met Arg Arg 
        355                 360                 365             


Leu Ala Asn Thr Ala Pro Ala Trp Gly Lys Pro Ile Pro Asn Pro Leu 
    370                 375                 380                 


Leu Gly Leu Asp Ser Thr Pro Ser Tyr Asp Ser Val Arg Arg Gly Ala 
385                 390                 395                 400 


Trp Gly Asn Asn Met Asn Ser Gly Leu Asn Lys Ser Pro Pro Leu Gly 
                405                 410                 415     


Gly Ala Gln Thr Ile Ser Lys Asn Thr Glu Gln Arg Pro Gln Pro Asp 
            420                 425                 430         


Pro Tyr Gln Ile Leu Gly Pro Thr Ser Ser Arg Leu Ala Asn Pro Gly 
        435                 440                 445             


Ser Gly Gln Ile Gln Leu Trp Gln Phe Leu Leu Glu Leu Leu Ser Asp 
    450                 455                 460                 


Ser Ala Asn Ala Ser Cys Ile Thr Trp Glu Gly Thr Asn Gly Glu Phe 
465                 470                 475                 480 


Lys Met Thr Asp Pro Asp Glu Val Ala Arg Arg Trp Gly Glu Arg Lys 
                485                 490                 495     


Ser Lys Pro Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu Arg Tyr 
            500                 505                 510         


Tyr Tyr Asp Lys Asn Ile Met Thr Lys Val His Gly Lys Arg Tyr Ala 
        515                 520                 525             


Tyr Lys Phe Asp Phe His Gly Ile Ala Gln Ala Leu Gln Pro His Pro 
    530                 535                 540                 


Thr Glu Ser Ser Met Tyr Lys Tyr Pro Ser Asp Ile Ser Tyr Met Pro 
545                 550                 555                 560 


Ser Tyr His Ala His Gln Gln Lys Val Asn Phe Val Pro Pro His Pro 
                565                 570                 575     


Ser Ser Met Pro Val Thr Ser Ser Ser Phe Phe Gly Ala Ala Ser Gln 
            580                 585                 590         


Tyr Trp Thr Ser Pro Thr Gly Gly Ile Tyr Pro Asn Pro Asn Val Pro 
        595                 600                 605             


Arg His Pro Asn Thr His Val Pro Ser His Leu Gly Ser Tyr Tyr 
    610                 615                 620             


<210>  10
<211>  1497
<212>  DNA
<213>  Homo sapiens

<400>  10
atggcgtcca cggattacag tacctatagc caagctgcag cgcagcaggg ctacagtgct       60

tacaccgccc agcccactca aggatatgca cagaccaccc aggcatatgg gcaacaaagc      120

tatggaacct atggacagcc cactgatgtc agctataccc aggctcagac cactgcaacc      180

tatgggcaga ccgcctatgc aacttcttat ggacagcctc ccactggtta tactactcca      240

actgcccccc aggcatacag ccagcctgtc caggggtatg gcactggtgc ttatgatacc      300

accactgcta cagtcaccac cacccaggcc tcctatgcag ctcagtctgc atatggcact      360

cagcctgctt atccagccta tgggcagcag ccagcagcca ctgcacctac aagaccgcag      420

gatggaaaca agcccactga gactagtcaa cctcaatcta gcacaggggg ttacaaccag      480

cccagcctag gatatggaca gagtaactac agttatcccc aggtacctgg gagctacccc      540

atgcagccag tcactgcacc tccatcctac cctcctacca gctattcctc tacacagccg      600

actagttatg atcagagcag ttactctcag cagaacacct atgggcaacc gagcagctat      660

ggacagcaga gtagctatgg tcaacaaagc agctatgggc agcagcctcc cactagttac      720

ccaccccaaa ctggatccta cagccaagct ccaagtcaat atagccaaca gagcagcagc      780

tacgggcagc agaacccttc ttatgactca gtcagaagag gagcttgggg caataacatg      840

aattctggcc tcaacaaaag tcctcccctt ggaggggcac aaacgatcag taagaataca      900

gagcaacggc cccagccaga tccgtatcag atcctgggcc cgaccagcag tcgcctagcc      960

aaccctggaa gcgggcagat ccagctgtgg caattcctcc tggagctgct ctccgacagc     1020

gccaacgcca gctgtatcac ctgggagggg accaacgggg agttcaaaat gacggacccc     1080

gatgaggtgg ccaggcgctg gggcgagcgg aaaagcaagc ccaacatgaa ttacgacaag     1140

ctgagccggg ccctccgtta ttactatgat aaaaacatta tgaccaaagt gcacggcaaa     1200

agatatgctt acaaatttga cttccacggc attgcccagg ctctgcagcc acatccgacc     1260

gagtcgtcca tgtacaagta cccttctgac atctcctaca tgccttccta ccatgcccac     1320

cagcagaagg tgaactttgt ccctccccat ccatcctcca tgcctgtcac ttcctccagc     1380

ttctttggag ccgcatcaca atactggacc tcccccacgg ggggaatcta ccccaacccc     1440

aacgtccccc gccatcctaa cacccacgtg ccttcacact taggcagcta ctactaa        1497


<210>  11
<211>  1563
<212>  DNA
<213>  Homo sapiens

<400>  11
atggcgtcca cggattacag tacctatagc caagctgcag cgcagcaggg ctacagtgct       60

tacaccgccc agcccactca aggatatgca cagaccaccc aggcatatgg gcaacaaagc      120

tatggaacct atggacagcc cactgatgtc agctataccc aggctcagac cactgcaacc      180

tatgggcaga ccgcctatgc aacttcttat ggacagcctc ccactggtta tactactcca      240

actgcccccc aggcatacag ccagcctgtc caggggtatg gcactggtgc ttatgatacc      300

accactgcta cagtcaccac cacccaggcc tcctatgcag ctcagtctgc atatggcact      360

cagcctgctt atccagccta tgggcagcag ccagcagcca ctgcacctac aagaccgcag      420

gatggaaaca agcccactga gactagtcaa cctcaatcta gcacaggggg ttacaaccag      480

cccagcctag gatatggaca gagtaactac agttatcccc aggtacctgg gagctacccc      540

atgcagccag tcactgcacc tccatcctac cctcctacca gctattcctc tacacagccg      600

actagttatg atcagagcag ttactctcag cagaacacct atgggcaacc gagcagctat      660

ggacagcaga gtagctatgg tcaacaaagc agctatgggc agcagcctcc cactagttac      720

ccaccccaaa ctggatccta cagccaagct ccaagtcaat atagccaaca gagcagcagc      780

tacgggcagc agagttcact gctggcctat aatacaacct cccacaccga ccaatcctca      840

cgattgagtg tcaaagaaga cccttcttat gactcagtca gaagaggagc ttggggcaat      900

aacatgaatt ctggcctcaa caaaagtcct ccccttggag gggcacaaac gatcagtaag      960

aatacagagc aacggcccca gccagatccg tatcagatcc tgggcccgac cagcagtcgc     1020

ctagccaacc ctggaagcgg gcagatccag ctgtggcaat tcctcctgga gctgctctcc     1080

gacagcgcca acgccagctg tatcacctgg gaggggacca acggggagtt caaaatgacg     1140

gaccccgatg aggtggccag gcgctggggc gagcggaaaa gcaagcccaa catgaattac     1200

gacaagctga gccgggccct ccgttattac tatgataaaa acattatgac caaagtgcac     1260

ggcaaaagat atgcttacaa atttgacttc cacggcattg cccaggctct gcagccacat     1320

ccgaccgagt cgtccatgta caagtaccct tctgacatct cctacatgcc ttcctaccat     1380

gcccaccagc agaaggtgaa ctttgtccct ccccatccat cctccatgcc tgtcacttcc     1440

tccagcttct ttggagccgc atcacaatac tggacctccc ccacgggggg aatctacccc     1500

aaccccaacg tcccccgcca tcctaacacc cacgtgcctt cacacttagg cagctactac     1560

tag                                                                   1563


<210>  12
<211>  702
<212>  DNA
<213>  Homo sapiens

<400>  12
ccttcttatg actcagtcag aagaggagct tggggcaata acatgaattc tggcctcaac       60

aaaagtcctc cccttggagg ggcacaaacg atcagtaaga atacagagca acggccccag      120

ccagatccgt atcagatcct gggcccgacc agcagtcgcc tagccaaccc tggaagcggg      180

cagatccagc tgtggcaatt cctcctggag ctgctctccg acagcgccaa cgccagctgt      240

atcacctggg aggggaccaa cggggagttc aaaatgacgg accccgatga ggtggccagg      300

cgctggggcg agcggaaaag caagcccaac atgaattacg acaagctgag ccgggccctc      360

cgttattact atgataaaaa cattatgacc aaagtgcacg gcaaaagata tgcttacaaa      420

tttgacttcc acggcattgc ccaggctctg cagccacatc cgaccgagtc gtccatgtac      480

aagtaccctt ctgacatctc ctacatgcct tcctaccatg cccaccagca gaaggtgaac      540

tttgtccctc cccatccatc ctccatgcct gtcacttcct ccagcttctt tggagccgca      600

tcacaatact ggacctcccc cacgggggga atctacccca accccaacgt cccccgccat      660

cctaacaccc acgtgccttc acacttaggc agctactact ag                         702


<210>  13
<211>  1497
<212>  DNA
<213>  Homo sapiens

<400>  13
atggcgtcca cggattacag tacctatagc caagctgcag cgcagcaggg ctccagtgct       60

tacaccgccc agcccactca aggatatgct caaactactc aagcctatgg tcagcagtct      120

tccggcacct atggccagcc taccgacgtg agctatacac aggctcaaac aacggcgact      180

tatgggcaaa cagcctatgc gacaagttca ggacaaccgc ctaccggata tactacgccg      240

accgccccac aggcctattc ccagcctgtc caaggttctg ggactggcgc ttatgacact      300

actaccgcca cggtaactac cacccaagcg tcctatgccg cccagagcgc gtatggcacc      360

caacctgcgt atccggcata tggacaacaa cccgcagcca ccgcccccac gcgccctcag      420

gatggcaata aacccacgga aacatcccaa ccccaatcat ccacgggcgg atacaaccag      480

ccatcactcg gctcagggca aagtaattac agctatcctc aagtgccggg ttcctacccg      540

atgcaacccg tcactgcacc gccgtcttac ccgcccacta gctcttcctc tacacagccg      600

actagttatg atcagagcag ttcctctcag cagaacacct atgggcaacc gagcagctct      660

ggacagcaga gtagctctgg tcaacaaagc agctctgggc agcagcctcc cactagttac      720

ccaccccaaa ctggatcctc cagccaagct ccaagtcaat atagccaaca gagcagcagc      780

tccgggcagc agaacccttc ttatgactca gtcagaagag gagcttgggg caataacatg      840

aattctggcc tcaacaaaag tcctcccctt ggaggggcac aaacgatcag taagaataca      900

gagcaacggc cccagccaga tccgtatcag atcctgggcc cgaccagcag tcgcctagcc      960

aaccctggaa gcgggcagat ccagctgtgg caattcctcc tggagctgct ctccgacagc     1020

gccaacgcca gctgtatcac ctgggagggg accaacgggg agttcaaaat gacggacccc     1080

gatgaggtgg ccaggcgctg gggcgagcgg aaaagcaagc ccaacatgaa ttacgacaag     1140

ctgagccggg ccctccgtta ttactatgat aaaaacatta tgaccaaagt gcacggcaaa     1200

agatatgctt acaaatttga cttccacggc attgcccagg ctctgcagcc acatccgacc     1260

gagtcgtcca tgtacaagta cccttctgac atctcctaca tgccttccta ccatgcccac     1320

cagcagaagg tgaactttgt ccctccccat ccatcctcca tgcctgtcac ttcctccagc     1380

ttctttggag ccgcatcaca atactggacc tcccccacgg ggggaatcta ccccaacccc     1440

aacgtccccc gccatcctaa cacccacgtg ccttcacact taggcagcta ctactaa        1497


<210>  14
<211>  1497
<212>  DNA
<213>  Homo sapiens

<400>  14
atggcgtcca cggattccag tacctctagc caagctgcag cgcagcaggg ctccagtgct       60

tccaccgccc agcccactca aggatccgct caaactactc aagcctccgg tcagcagtct      120

tcaggcacct ccggccagcc taccgacgtg agcagtacac aggctcaaac aacggcgact      180

agcgggcaaa cagcctccgc gacaagttca ggacaaccgc ctaccggatc tactacgccg      240

accgccccac aggccagttc ccagcctgtc caaggttctg ggactggcgc tagtgacact      300

actaccgcca cggtaactac cacccaagcg tccagtgccg cccagagcgc gtcaggcacc      360

caacctgcgt ctccggcaag tggacaacaa cccgcagcca ccgcccccac gcgccctcag      420

gatggcaata aacccacgga aacatcccaa ccccaatcat ccacgggcgg atcaaaccag      480

ccatcactcg gctcagggca aagtaattcc agctcccctc aagtgccggg ttcctccccg      540

atgcaacccg tcactgcacc gccgtctagc ccgcccacta gctcttcctc tacacagccg      600

actagttctg atcagagcag ttcctctcag cagaacacct ctgggcaacc gagcagctct      660

ggacagcaga gtagctctgg tcaacaaagc agctctgggc agcagcctcc cactagttcc      720

ccaccccaaa ctggatcctc cagccaagct ccaagtcaat ctagccaaca gagcagcagc      780

tccgggcagc agaacccttc ttatgactca gtcagaagag gagcttgggg caataacatg      840

aattctggcc tcaacaaaag tcctcccctt ggaggggcac aaacgatcag taagaataca      900

gagcaacggc cccagccaga tccgtatcag atcctgggcc cgaccagcag tcgcctagcc      960

aaccctggaa gcgggcagat ccagctgtgg caattcctcc tggagctgct ctccgacagc     1020

gccaacgcca gctgtatcac ctgggagggg accaacgggg agttcaaaat gacggacccc     1080

gatgaggtgg ccaggcgctg gggcgagcgg aaaagcaagc ccaacatgaa ttacgacaag     1140

ctgagccggg ccctccgtta ttactatgat aaaaacatta tgaccaaagt gcacggcaaa     1200

agatatgctt acaaatttga cttccacggc attgcccagg ctctgcagcc acatccgacc     1260

gagtcgtcca tgtacaagta cccttctgac atctcctaca tgccttccta ccatgcccac     1320

cagcagaagg tgaactttgt ccctccccat ccatcctcca tgcctgtcac ttcctccagc     1380

ttctttggag ccgcatcaca atactggacc tcccccacgg ggggaatcta ccccaacccc     1440

aacgtccccc gccatcctaa cacccacgtg ccttcacact taggcagcta ctactaa        1497


<210>  15
<211>  816
<212>  DNA
<213>  Homo sapiens

<400>  15
tatgggcaac aaagctatgg aacctatgga cagcccactg atgtcagcta tacccaggct       60

cagaccactg caacctatgg gcagaccgcc tatgcaactt cttatggaca gaacccttct      120

tatgactcag tcagaagagg agcttggggc aataacatga attctggcct caacaaaagt      180

cctccccttg gaggggcaca aacgatcagt aagaatacag agcaacggcc ccagccagat      240

ccgtatcaga tcctgggccc gaccagcagt cgcctagcca accctggaag cgggcagatc      300

cagctgtggc aattcctcct ggagctgctc tccgacagcg ccaacgccag ctgtatcacc      360

tgggagggga ccaacgggga gttcaaaatg acggaccccg atgaggtggc caggcgctgg      420

ggcgagcgga aaagcaagcc caacatgaat tacgacaagc tgagccgggc cctccgttat      480

tactatgata aaaacattat gaccaaagtg cacggcaaaa gatatgctta caaatttgac      540

ttccacggca ttgcccaggc tctgcagcca catccgaccg agtcgtccat gtacaagtac      600

ccttctgaca tctcctacat gccttcctac catgcccacc agcagaaggt gaactttgtc      660

cctccccatc catcctccat gcctgtcact tcctccagct tctttggagc cgcatcacaa      720

tactggacct cccccacggg gggaatctac cccaacccca acgtcccccg ccatcctaac      780

acccacgtgc cttcacactt aggcagctac tactaa                                816


<210>  16
<211>  897
<212>  DNA
<213>  Homo sapiens

<400>  16
actagttatg atcagagcag ttactctcag cagaacacct atgggcaacc gagcagctat       60

ggacagcaga gtagctatgg tcaacaaagc agctatgggc agcagcctcc cactagttac      120

ccaccccaaa ctggatccta cagccaagct ccaagtcaat atagccaaca gagcagcagc      180

tacgggcagc agaacccttc ttatgactca gtcagaagag gagcttgggg caataacatg      240

aattctggcc tcaacaaaag tcctcccctt ggaggggcac aaacgatcag taagaataca      300

gagcaacggc cccagccaga tccgtatcag atcctgggcc cgaccagcag tcgcctagcc      360

aaccctggaa gcgggcagat ccagctgtgg caattcctcc tggagctgct ctccgacagc      420

gccaacgcca gctgtatcac ctgggagggg accaacgggg agttcaaaat gacggacccc      480

gatgaggtgg ccaggcgctg gggcgagcgg aaaagcaagc ccaacatgaa ttacgacaag      540

ctgagccggg ccctccgtta ttactatgat aaaaacatta tgaccaaagt gcacggcaaa      600

agatatgctt acaaatttga cttccacggc attgcccagg ctctgcagcc acatccgacc      660

gagtcgtcca tgtacaagta cccttctgac atctcctaca tgccttccta ccatgcccac      720

cagcagaagg tgaactttgt ccctccccat ccatcctcca tgcctgtcac ttcctccagc      780

ttctttggag ccgcatcaca atactggacc tcccccacgg ggggaatcta ccccaacccc      840

aacgtccccc gccatcctaa cacccacgtg ccttcacact taggcagcta ctactaa         897


<210>  17
<211>  1872
<212>  DNA
<213>  Homo sapiens

<400>  17
atgatgatga tggcgctgag caagaccttc gggcagaagc ccgtgaagtt ccagctggag       60

gacgacggcg agttctacat gatcggctcc gaggtgggaa actacctccg tatgttccga      120

ggttctctgt acaagagata cccctcactc tggaggcgac tagccactgt ggaagagagg      180

aagaaaatag ttgcatcgtc acatgatcac ggatacacga ctctagccac cagtgtgacc      240

ctgttaaaag cctcggaagt ggaagagatt ctggatggca acgatgagaa gtacaaggct      300

gtgtccatca gcacagagcc ccccacctac ctcagggaac agaaggccaa gaggaacagc      360

cagtgggtac ccaccctgcc caacagctcc caccacttag atgccgtgcc atgctccaca      420

accatcaaca ggaaccgcat gggccgagac aagaagagaa ccttccccct ttgctttgat      480

gaccatgacc cagctgtgat ccatgagaac gcatctcagc ccgaggtgct ggtccccatc      540

cggctggaca tggagatcga tgggcagaag ctgcgagacg ccttcacctg gaacatgaat      600

gagaagttga tgacgcctga gatgttttca gaaatcctct gtgacgatct ggatttgaac      660

ccgctgacgt ttgtgccagc catcgcctct gccatcagac agcagatcga gtcctacccc      720

acggacagca tcctggagga ccagtcagac cagcgcgtca tcatcaagct gaacatccat      780

gtgggaaaca tttccctggt ggaccagttt gagtgggaca tgtcagagaa ggagaactca      840

ccagagaagt ttgccctgaa gctgtgctcg gagctggggt tgggcgggga gtttgtcacc      900

accatcgcat acagcatccg gggacagctg agctggcatc agaagaccta cgccttcagc      960

gagaaccctc tgcccacagt ggagattgcc atccggaaca cgggcgatgc ggaccagtgg     1020

tgcccactgc tggagactct gacagacgct gagatggaga agaagatccg cgaccaggac     1080

aggaacacga ggcggatgag gcgtcttgcc aacacggccc cggcctgggg taagcctatc     1140

cctaaccctc tcctcggtct cgattctacg ccttcttatg actcagtcag aagaggagct     1200

tggggcaata acatgaattc tggcctcaac aaaagtcctc cccttggagg ggcacaaacg     1260

atcagtaaga atacagagca acggccccag ccagatccgt atcagatcct gggcccgacc     1320

agcagtcgcc tagccaaccc tggaagcggg cagatccagc tgtggcaatt cctcctggag     1380

ctgctctccg acagcgccaa cgccagctgt atcacctggg aggggaccaa cggggagttc     1440

aaaatgacgg accccgatga ggtggccagg cgctggggcg agcggaaaag caagcccaac     1500

atgaattacg acaagctgag ccgggccctc cgttattact atgataaaaa cattatgacc     1560

aaagtgcacg gcaaaagata tgcttacaaa tttgacttcc acggcattgc ccaggctctg     1620

cagccacatc cgaccgagtc gtccatgtac aagtaccctt ctgacatctc ctacatgcct     1680

tcctaccatg cccaccagca gaaggtgaac tttgtccctc cccatccatc ctccatgcct     1740

gtcacttcct ccagcttctt tggagccgca tcacaatact ggacctcccc cacgggggga     1800

atctacccca accccaacgt cccccgccat cctaacaccc acgtgccttc acacttaggc     1860

agctactact ag                                                         1872


<210>  18
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  18
caccgaagga ggcacttaca ca                                                22


<210>  19
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  19
tgccattcac gagcctgtcg ta                                                22


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  20
tggcgatgag caccactact                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  21
ggaggacttg gctggagatt                                                   20


<210>  22
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  22
atatccgagc cgaagcagac ac                                                22


<210>  23
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  23
cggcatttct cctggtattc cg                                                22


<210>  24
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  24
tgttggaggc ttgatggaaa aacc                                              24


<210>  25
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  25
cggattctga caggtgttca cc                                                22


<210>  26
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  26
tgagggtatc gcagagaacg ga                                                22


<210>  27
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  27
cggtcactta tcctgtggct gg                                                22


<210>  28
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  28
ccatcggact ctcataggtt gtc                                               23


<210>  29
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  29
gacctgtact tattgtctct catc                                              24


<210>  30
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  30
gacgcagctc attcagcag                                                    19


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  31
ctcgcacttg accttgtagg c                                                 21


<210>  32
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  32
cacagaagtg gagtcaaggc tg                                                22


<210>  33
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  33
ttggctccct tggaatccag tg                                                22


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  34
aggggaccgt gctctttaac                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  35
ctgagttccc cactggagtc                                                   20


<210>  36
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  36
cctcatccct gtctattgct cc                                                22


<210>  37
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  37
gttggctcct tgcttgttct gc                                                22


<210>  38
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  38
ttcagccgag gctctcctaa tg                                                22


<210>  39
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  39
gcctgaaacc ttttccgcac ac                                                22


<210>  40
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  40
cagcgacaac ccgtacac                                                     18


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  41
gacttggagc ttgagtcctg a                                                 21


<210>  42
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  42
gagggacaca tcaagattgc cg                                                22


<210>  43
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  43
caccaatcca cggacttccc at                                                22


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  44
tgggaaagta cacggggata                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  45
tattgaccaa gggcattcac                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  46
ggtctcctct gacttcaaca                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  47
gtgagggtct ctctcttcct                                                   20


<210>  48
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  48
cattatgctg aggatttgga aagg                                              24


<210>  49
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  49
cttgagcaca cagagggcta ca                                                22


<210>  50
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  50
accatctacg gcgaggagta tg                                                22


<210>  51
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  51
cccaggtcaa tggcatagat gg                                                22


<210>  52
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  52
gagaatggac tgaacaggag acc                                               23


<210>  53
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  53
gggtcctcaa tgggaagtct ca                                                22


<210>  54
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  54
acacaccatt tagtaaaggc caa                                               23


<210>  55
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  55
aggaatttgg ggatttctca atcaa                                             25


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  56
gaagtgcacc ctatgccagt                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  57
tcctctgtgg gggttatcca                                                   20


<210>  58
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  58
gattctgtat cagctggtat atacc                                             25


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  59
gcatcaggaa gcctggatcc                                                   20


<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  60
ttctttttgg tctgctggaa                                                   20


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  61
cgtgcctgac actcttcaac                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  62
agcccttcca ggaacagaac                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  63
ttcccaaata cccttcagca                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  64
atattggagc cccaagggtt                                                   20


<210>  65
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  65
ctcattagca gcggtggcac                                                   20


<210>  66
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic shRNA 
       sequence"

<400>  66
cgtcatgttc tggtttgaga t                                                 21


<210>  67
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic shRNA 
       sequence"

<400>  67
cccaccacat ttacccatat t                                                 21


<210>  68
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic shRNA 
       sequence"

<400>  68
gcaggatatt agctccttat a                                                 21


<210>  69
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic shRNA 
       sequence"

<400>  69
ggcataggcc ttagcagtaa c                                                 21


<210>  70
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic EWSR1 
       prion-like domain sequence"

<400>  70

Ser Tyr Gly Gln 
1               


<210>  71
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic AP2 motif 
       sequence"


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  s is c or g

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  y is c or t

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  h is a, c, or t

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  d is a, g, or t

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  s is c or g

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  h is a, c, or t

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is a, c, g, or t

<400>  71
nscyhndggs hnnn                                                         14


<210>  72
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic EWS-FLI1 
       motif sequence"

<400>  72
aaggaaggaa ggaagg                                                       16


<210>  73
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic control MSC 
       motif sequence"


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  k is g or t

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is a, c, g, or t

<400>  73
nntkantman n                                                            11


<210>  74
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic EWS-FLI1 MSC
       sequence"

<400>  74
aggaaggaag gaag                                                         14


<210>  75
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Ala Ser Thr Asp Tyr Ser Thr Tyr Ser Gln Ala Ala Ala Gln Gln 
1               5                   10                  15      


Gly Tyr Ser Ala Tyr Thr Ala Gln Pro Thr Gln Gly Tyr Ala Gln Thr 
            20                  25                  30          


Thr Gln Ala Tyr Gly Gln Gln Ser Tyr Gly Thr Tyr Gly Gln Pro Thr 
        35                  40                  45              


Asp Val Ser Tyr Thr Gln Ala Gln Thr Thr Ala Thr Tyr Gly Gln Thr 
    50                  55                  60                  


Ala Tyr Ala Thr Ser Tyr Gly Gln Pro Pro Thr Gly Tyr Thr Thr Pro 
65                  70                  75                  80  


Thr Ala Pro Gln Ala Tyr Ser Gln Pro Val Gln Gly Tyr Gly Thr Gly 
                85                  90                  95      


Ala Tyr Asp Thr Thr Thr Ala Thr Val Thr Thr Thr Gln Ala Ser Tyr 
            100                 105                 110         


Ala Ala Gln Ser Ala Tyr Gly Thr Gln Pro Ala Tyr Pro Ala Tyr Gly 
        115                 120                 125             


Gln Gln Pro Ala Ala Thr Ala Pro Thr Arg Pro Gln Asp Gly Asn Lys 
    130                 135                 140                 


Pro Thr Glu Thr Ser Gln Pro Gln Ser Ser Thr Gly Gly Tyr Asn Gln 
145                 150                 155                 160 


Pro Ser Leu Gly Tyr Gly Gln Ser Asn Tyr Ser Tyr Pro Gln Val Pro 
                165                 170                 175     


Gly Ser Tyr Pro Met Gln Pro Val Thr Ala Pro Pro Ser Tyr Pro Pro 
            180                 185                 190         


Thr Ser Tyr Ser Ser Thr Gln Pro Thr Ser Tyr Asp Gln Ser Ser Tyr 
        195                 200                 205             


Ser Gln Gln Asn Thr Tyr Gly Gln Pro Ser Ser Tyr Gly Gln Gln Ser 
    210                 215                 220                 


Ser Tyr Gly Gln Gln Ser Ser Tyr Gly Gln Gln Pro Pro Thr Ser Tyr 
225                 230                 235                 240 


Pro Pro Gln Thr Gly Ser Tyr Ser Gln Ala Pro Ser Gln Tyr Ser Gln 
                245                 250                 255     


Gln Ser Ser Ser Tyr Gly Gln Gln 
            260                 


<210>  76
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic EWS-FLI1 
       binding sequence sequence"

<400>  76
ggaaggaagg aaggaa                                                       16