                         SEQUENCE LISTING

<110>  BAR-ILAN UNIVERSITY
       OPATOWSKY, Yarden
       BARAK-FUCKS, Reut
       GUEZ-HADDAD, Julia
       YOM-TOV, Galit
 
<120>  ROUNDABOUT (ROBO) RECEPTOR INHIBITORS AND USES THEREOF

<130>  74417

<150>  US 62/549,472
<151>  2017-08-24

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  1394
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Arg Arg His Glu Arg Val Thr Arg Arg Met Trp Thr Trp Ala 
1               5                   10                  15      


Pro Gly Leu Leu Met Met Thr Val Val Phe Trp Gly His Gln Gly Asn 
            20                  25                  30          


Gly Gln Gly Gln Gly Ser Arg Leu Arg Gln Glu Asp Phe Pro Pro Arg 
        35                  40                  45              


Ile Val Glu His Pro Ser Asp Val Ile Val Ser Lys Gly Glu Pro Thr 
    50                  55                  60                  


Thr Leu Asn Cys Lys Ala Glu Gly Arg Pro Thr Pro Thr Ile Glu Trp 
65                  70                  75                  80  


Tyr Lys Asp Gly Glu Arg Val Glu Thr Asp Lys Asp Asp Pro Arg Ser 
                85                  90                  95      


His Arg Met Leu Leu Pro Ser Gly Ser Leu Phe Phe Leu Arg Ile Val 
            100                 105                 110         


His Gly Arg Arg Ser Lys Pro Asp Glu Gly Ser Tyr Val Cys Val Ala 
        115                 120                 125             


Arg Asn Tyr Leu Gly Glu Ala Val Ser Arg Asn Ala Ser Leu Glu Val 
    130                 135                 140                 


Ala Leu Leu Arg Asp Asp Phe Arg Gln Asn Pro Thr Asp Val Val Val 
145                 150                 155                 160 


Ala Ala Gly Glu Pro Ala Ile Leu Glu Cys Gln Pro Pro Arg Gly His 
                165                 170                 175     


Pro Glu Pro Thr Ile Tyr Trp Lys Lys Asp Lys Val Arg Ile Asp Asp 
            180                 185                 190         


Lys Glu Glu Arg Ile Ser Ile Arg Gly Gly Lys Leu Met Ile Ser Asn 
        195                 200                 205             


Thr Arg Lys Ser Asp Ala Gly Met Tyr Thr Cys Val Gly Thr Asn Met 
    210                 215                 220                 


Val Gly Glu Arg Asp Ser Asp Pro Ala Glu Leu Thr Val Phe Glu Arg 
225                 230                 235                 240 


Pro Thr Phe Leu Arg Arg Pro Ile Asn Gln Val Val Leu Glu Glu Glu 
                245                 250                 255     


Ala Val Glu Phe Arg Cys Gln Val Gln Gly Asp Pro Gln Pro Thr Val 
            260                 265                 270         


Arg Trp Lys Lys Asp Asp Ala Asp Leu Pro Arg Gly Arg Tyr Asp Ile 
        275                 280                 285             


Lys Asp Asp Tyr Thr Leu Arg Ile Lys Lys Thr Met Ser Thr Asp Glu 
    290                 295                 300                 


Gly Thr Tyr Met Cys Ile Ala Glu Asn Arg Val Gly Lys Met Glu Ala 
305                 310                 315                 320 


Ser Ala Thr Leu Thr Val Arg Ala Pro Pro Gln Phe Val Val Arg Pro 
                325                 330                 335     


Arg Asp Gln Ile Val Ala Gln Gly Arg Thr Val Thr Phe Pro Cys Glu 
            340                 345                 350         


Thr Lys Gly Asn Pro Gln Pro Ala Val Phe Trp Gln Lys Glu Gly Ser 
        355                 360                 365             


Gln Asn Leu Leu Phe Pro Asn Gln Pro Gln Gln Pro Asn Ser Arg Cys 
    370                 375                 380                 


Ser Val Ser Pro Thr Gly Asp Leu Thr Ile Thr Asn Ile Gln Arg Ser 
385                 390                 395                 400 


Asp Ala Gly Tyr Tyr Ile Cys Gln Ala Leu Thr Val Ala Gly Ser Ile 
                405                 410                 415     


Leu Ala Lys Ala Gln Leu Glu Val Thr Asp Val Leu Thr Asp Arg Pro 
            420                 425                 430         


Pro Pro Ile Ile Leu Gln Gly Pro Ala Asn Gln Thr Leu Ala Val Asp 
        435                 440                 445             


Gly Thr Ala Leu Leu Lys Cys Lys Ala Thr Gly Asp Pro Leu Pro Val 
    450                 455                 460                 


Ile Ser Trp Leu Lys Glu Gly Phe Thr Phe Pro Gly Arg Asp Pro Arg 
465                 470                 475                 480 


Ala Thr Ile Gln Glu Gln Gly Thr Leu Gln Ile Lys Asn Leu Arg Ile 
                485                 490                 495     


Ser Asp Thr Gly Thr Tyr Thr Cys Val Ala Thr Ser Ser Ser Gly Glu 
            500                 505                 510         


Thr Ser Trp Ser Ala Val Leu Asp Val Thr Glu Ser Gly Ala Thr Ile 
        515                 520                 525             


Ser Lys Asn Tyr Asp Leu Ser Asp Leu Pro Gly Pro Pro Ser Lys Pro 
    530                 535                 540                 


Gln Val Thr Asp Val Thr Lys Asn Ser Val Thr Leu Ser Trp Gln Pro 
545                 550                 555                 560 


Gly Thr Pro Gly Thr Leu Pro Ala Ser Ala Tyr Ile Ile Glu Ala Phe 
                565                 570                 575     


Ser Gln Ser Val Ser Asn Ser Trp Gln Thr Val Ala Asn His Val Lys 
            580                 585                 590         


Thr Thr Leu Tyr Thr Val Arg Gly Leu Arg Pro Asn Thr Ile Tyr Leu 
        595                 600                 605             


Phe Met Val Arg Ala Ile Asn Pro Gln Gly Leu Ser Asp Pro Ser Pro 
    610                 615                 620                 


Met Ser Asp Pro Val Arg Thr Gln Asp Ile Ser Pro Pro Ala Gln Gly 
625                 630                 635                 640 


Val Asp His Arg Gln Val Gln Lys Glu Leu Gly Asp Val Leu Val Arg 
                645                 650                 655     


Leu His Asn Pro Val Val Leu Thr Pro Thr Thr Val Gln Val Thr Trp 
            660                 665                 670         


Thr Val Asp Arg Gln Pro Gln Phe Ile Gln Gly Tyr Arg Val Met Tyr 
        675                 680                 685             


Arg Gln Thr Ser Gly Leu Gln Ala Thr Ser Ser Trp Gln Asn Leu Asp 
    690                 695                 700                 


Ala Lys Val Pro Thr Glu Arg Ser Ala Val Leu Val Asn Leu Lys Lys 
705                 710                 715                 720 


Gly Val Thr Tyr Glu Ile Lys Val Arg Pro Tyr Phe Asn Glu Phe Gln 
                725                 730                 735     


Gly Met Asp Ser Glu Ser Lys Thr Val Arg Thr Thr Glu Glu Ala Pro 
            740                 745                 750         


Ser Ala Pro Pro Gln Ser Val Thr Val Leu Thr Val Gly Ser Tyr Asn 
        755                 760                 765             


Ser Thr Ser Ile Ser Val Ser Trp Asp Pro Pro Pro Pro Asp His Gln 
    770                 775                 780                 


Asn Gly Ile Ile Gln Glu Tyr Lys Ile Trp Cys Leu Gly Asn Glu Thr 
785                 790                 795                 800 


Arg Phe His Ile Asn Lys Thr Val Asp Ala Ala Ile Arg Ser Val Ile 
                805                 810                 815     


Ile Gly Gly Leu Phe Pro Gly Ile Gln Tyr Arg Val Glu Val Ala Ala 
            820                 825                 830         


Ser Thr Ser Ala Gly Val Gly Val Lys Ser Glu Pro Gln Pro Ile Ile 
        835                 840                 845             


Ile Gly Arg Arg Asn Glu Val Val Ile Thr Glu Asn Asn Asn Ser Ile 
    850                 855                 860                 


Thr Glu Gln Ile Thr Asp Val Val Lys Gln Pro Ala Phe Ile Ala Gly 
865                 870                 875                 880 


Ile Gly Gly Ala Cys Trp Val Ile Leu Met Gly Phe Ser Ile Trp Leu 
                885                 890                 895     


Tyr Trp Arg Arg Lys Lys Arg Lys Gly Leu Ser Asn Tyr Ala Val Thr 
            900                 905                 910         


Phe Gln Arg Gly Asp Gly Gly Leu Met Ser Asn Gly Ser Arg Pro Gly 
        915                 920                 925             


Leu Leu Asn Ala Gly Asp Pro Ser Tyr Pro Trp Leu Ala Asp Ser Trp 
    930                 935                 940                 


Pro Ala Thr Ser Leu Pro Val Asn Asn Ser Asn Ser Gly Pro Asn Glu 
945                 950                 955                 960 


Ile Gly Asn Phe Gly Arg Gly Asp Val Leu Pro Pro Val Pro Gly Gln 
                965                 970                 975     


Gly Asp Lys Thr Ala Thr Met Leu Ser Asp Gly Ala Ile Tyr Ser Ser 
            980                 985                 990         


Ile Asp Phe Thr Thr Lys Thr Ser  Tyr Asn Ser Ser Ser  Gln Ile Thr 
        995                 1000                 1005             


Gln Ala  Thr Pro Tyr Ala Thr  Thr Gln Ile Leu His  Ser Asn Ser 
    1010                 1015                 1020             


Ile His  Glu Leu Ala Val Asp  Leu Pro Asp Pro Gln  Trp Lys Ser 
    1025                 1030                 1035             


Ser Ile  Gln Gln Lys Thr Asp  Leu Met Gly Phe Gly  Tyr Ser Leu 
    1040                 1045                 1050             


Pro Asp  Gln Asn Lys Gly Asn  Asn Gly Gly Lys Gly  Gly Lys Lys 
    1055                 1060                 1065             


Lys Lys  Asn Lys Asn Ser Ser  Lys Pro Gln Lys Asn  Asn Gly Ser 
    1070                 1075                 1080             


Thr Trp  Ala Asn Val Pro Leu  Pro Pro Pro Pro Val  Gln Pro Leu 
    1085                 1090                 1095             


Pro Gly  Thr Glu Leu Glu His  Tyr Ala Val Glu Gln  Gln Glu Asn 
    1100                 1105                 1110             


Gly Tyr  Asp Ser Asp Ser Trp  Cys Pro Pro Leu Pro  Val Gln Thr 
    1115                 1120                 1125             


Tyr Leu  His Gln Gly Leu Glu  Asp Glu Leu Glu Glu  Asp Asp Asp 
    1130                 1135                 1140             


Arg Val  Pro Thr Pro Pro Val  Arg Gly Val Ala Ser  Ser Pro Ala 
    1145                 1150                 1155             


Ile Ser  Phe Gly Gln Gln Ser  Thr Ala Thr Leu Thr  Pro Ser Pro 
    1160                 1165                 1170             


Arg Glu  Glu Met Gln Pro Met  Leu Gln Ala His Leu  Asp Glu Leu 
    1175                 1180                 1185             


Thr Arg  Ala Tyr Gln Phe Asp  Ile Ala Lys Gln Thr  Trp His Ile 
    1190                 1195                 1200             


Gln Ser  Asn Asn Gln Pro Pro  Gln Pro Pro Val Pro  Pro Leu Gly 
    1205                 1210                 1215             


Tyr Val  Ser Gly Ala Leu Ile  Ser Asp Leu Glu Thr  Asp Val Ala 
    1220                 1225                 1230             


Asp Asp  Asp Ala Asp Asp Glu  Glu Glu Ala Leu Glu  Ile Pro Arg 
    1235                 1240                 1245             


Pro Leu  Arg Ala Leu Asp Gln  Thr Pro Gly Ser Ser  Met Asp Asn 
    1250                 1255                 1260             


Leu Asp  Ser Ser Val Thr Gly  Lys Ala Phe Thr Ser  Ser Gln Arg 
    1265                 1270                 1275             


Pro Arg  Pro Thr Ser Pro Phe  Ser Thr Asp Ser Asn  Thr Ser Ala 
    1280                 1285                 1290             


Ala Leu  Ser Gln Ser Gln Arg  Pro Arg Pro Thr Lys  Lys His Lys 
    1295                 1300                 1305             


Gly Gly  Arg Met Asp Gln Gln  Pro Ala Leu Pro His  Arg Arg Glu 
    1310                 1315                 1320             


Gly Met  Thr Asp Glu Glu Ala  Leu Val Pro Tyr Ser  Lys Pro Ser 
    1325                 1330                 1335             


Phe Pro  Ser Pro Gly Gly His  Ser Ser Ser Gly Thr  Ala Ser Ser 
    1340                 1345                 1350             


Lys Gly  Ser Thr Gly Pro Arg  Lys Thr Glu Val Leu  Arg Ala Gly 
    1355                 1360                 1365             


His Gln  Arg Asn Ala Ser Asp  Leu Leu Asp Ile Gly  Tyr Met Gly 
    1370                 1375                 1380             


Ser Asn  Ser Gln Gly Gln Phe  Thr Gly Glu Leu 
    1385                 1390                 


<210>  2
<211>  1378
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Leu Leu Met Phe Thr Gln Leu Leu Leu Cys Gly Phe Leu Tyr 
1               5                   10                  15      


Val Arg Val Asp Gly Ser Arg Leu Arg Gln Glu Asp Phe Pro Pro Arg 
            20                  25                  30          


Ile Val Glu His Pro Ser Asp Val Ile Val Ser Lys Gly Glu Pro Thr 
        35                  40                  45              


Thr Leu Asn Cys Lys Ala Glu Gly Arg Pro Thr Pro Thr Ile Glu Trp 
    50                  55                  60                  


Tyr Lys Asp Gly Glu Arg Val Glu Thr Asp Lys Asp Asp Pro Arg Ser 
65                  70                  75                  80  


His Arg Met Leu Leu Pro Ser Gly Ser Leu Phe Phe Leu Arg Ile Val 
                85                  90                  95      


His Gly Arg Arg Ser Lys Pro Asp Glu Gly Ser Tyr Val Cys Val Ala 
            100                 105                 110         


Arg Asn Tyr Leu Gly Glu Ala Val Ser Arg Asn Ala Ser Leu Glu Val 
        115                 120                 125             


Ala Leu Leu Arg Asp Asp Phe Arg Gln Asn Pro Thr Asp Val Val Val 
    130                 135                 140                 


Ala Ala Gly Glu Pro Ala Ile Leu Glu Cys Gln Pro Pro Arg Gly His 
145                 150                 155                 160 


Pro Glu Pro Thr Ile Tyr Trp Lys Lys Asp Lys Val Arg Ile Asp Asp 
                165                 170                 175     


Lys Glu Glu Arg Ile Ser Ile Arg Gly Gly Lys Leu Met Ile Ser Asn 
            180                 185                 190         


Thr Arg Lys Ser Asp Ala Gly Met Tyr Thr Cys Val Gly Thr Asn Met 
        195                 200                 205             


Val Gly Glu Arg Asp Ser Asp Pro Ala Glu Leu Thr Val Phe Glu Arg 
    210                 215                 220                 


Pro Thr Phe Leu Arg Arg Pro Ile Asn Gln Val Val Leu Glu Glu Glu 
225                 230                 235                 240 


Ala Val Glu Phe Arg Cys Gln Val Gln Gly Asp Pro Gln Pro Thr Val 
                245                 250                 255     


Arg Trp Lys Lys Asp Asp Ala Asp Leu Pro Arg Gly Arg Tyr Asp Ile 
            260                 265                 270         


Lys Asp Asp Tyr Thr Leu Arg Ile Lys Lys Thr Met Ser Thr Asp Glu 
        275                 280                 285             


Gly Thr Tyr Met Cys Ile Ala Glu Asn Arg Val Gly Lys Met Glu Ala 
    290                 295                 300                 


Ser Ala Thr Leu Thr Val Arg Ala Pro Pro Gln Phe Val Val Arg Pro 
305                 310                 315                 320 


Arg Asp Gln Ile Val Ala Gln Gly Arg Thr Val Thr Phe Pro Cys Glu 
                325                 330                 335     


Thr Lys Gly Asn Pro Gln Pro Ala Val Phe Trp Gln Lys Glu Gly Ser 
            340                 345                 350         


Gln Asn Leu Leu Phe Pro Asn Gln Pro Gln Gln Pro Asn Ser Arg Cys 
        355                 360                 365             


Ser Val Ser Pro Thr Gly Asp Leu Thr Ile Thr Asn Ile Gln Arg Ser 
    370                 375                 380                 


Asp Ala Gly Tyr Tyr Ile Cys Gln Ala Leu Thr Val Ala Gly Ser Ile 
385                 390                 395                 400 


Leu Ala Lys Ala Gln Leu Glu Val Thr Asp Val Leu Thr Asp Arg Pro 
                405                 410                 415     


Pro Pro Ile Ile Leu Gln Gly Pro Ala Asn Gln Thr Leu Ala Val Asp 
            420                 425                 430         


Gly Thr Ala Leu Leu Lys Cys Lys Ala Thr Gly Asp Pro Leu Pro Val 
        435                 440                 445             


Ile Ser Trp Leu Lys Glu Gly Phe Thr Phe Pro Gly Arg Asp Pro Arg 
    450                 455                 460                 


Ala Thr Ile Gln Glu Gln Gly Thr Leu Gln Ile Lys Asn Leu Arg Ile 
465                 470                 475                 480 


Ser Asp Thr Gly Thr Tyr Thr Cys Val Ala Thr Ser Ser Ser Gly Glu 
                485                 490                 495     


Thr Ser Trp Ser Ala Val Leu Asp Val Thr Glu Ser Gly Ala Thr Ile 
            500                 505                 510         


Ser Lys Asn Tyr Asp Leu Ser Asp Leu Pro Gly Pro Pro Ser Lys Pro 
        515                 520                 525             


Gln Val Thr Asp Val Thr Lys Asn Ser Val Thr Leu Ser Trp Gln Pro 
    530                 535                 540                 


Gly Thr Pro Gly Thr Leu Pro Ala Ser Ala Tyr Ile Ile Glu Ala Phe 
545                 550                 555                 560 


Ser Gln Ser Val Ser Asn Ser Trp Gln Thr Val Ala Asn His Val Lys 
                565                 570                 575     


Thr Thr Leu Tyr Thr Val Arg Gly Leu Arg Pro Asn Thr Ile Tyr Leu 
            580                 585                 590         


Phe Met Val Arg Ala Ile Asn Pro Gln Gly Leu Ser Asp Pro Ser Pro 
        595                 600                 605             


Met Ser Asp Pro Val Arg Thr Gln Asp Ile Ser Pro Pro Ala Gln Gly 
    610                 615                 620                 


Val Asp His Arg Gln Val Gln Lys Glu Leu Gly Asp Val Leu Val Arg 
625                 630                 635                 640 


Leu His Asn Pro Val Val Leu Thr Pro Thr Thr Val Gln Val Thr Trp 
                645                 650                 655     


Thr Val Asp Arg Gln Pro Gln Phe Ile Gln Gly Tyr Arg Val Met Tyr 
            660                 665                 670         


Arg Gln Thr Ser Gly Leu Gln Ala Thr Ser Ser Trp Gln Asn Leu Asp 
        675                 680                 685             


Ala Lys Val Pro Thr Glu Arg Ser Ala Val Leu Val Asn Leu Lys Lys 
    690                 695                 700                 


Gly Val Thr Tyr Glu Ile Lys Val Arg Pro Tyr Phe Asn Glu Phe Gln 
705                 710                 715                 720 


Gly Met Asp Ser Glu Ser Lys Thr Val Arg Thr Thr Glu Glu Ala Pro 
                725                 730                 735     


Ser Ala Pro Pro Gln Ser Val Thr Val Leu Thr Val Gly Ser Tyr Asn 
            740                 745                 750         


Ser Thr Ser Ile Ser Val Ser Trp Asp Pro Pro Pro Pro Asp His Gln 
        755                 760                 765             


Asn Gly Ile Ile Gln Glu Tyr Lys Ile Trp Cys Leu Gly Asn Glu Thr 
    770                 775                 780                 


Arg Phe His Ile Asn Lys Thr Val Asp Ala Ala Ile Arg Ser Val Ile 
785                 790                 795                 800 


Ile Gly Gly Leu Phe Pro Gly Ile Gln Tyr Arg Val Glu Val Ala Ala 
                805                 810                 815     


Ser Thr Ser Ala Gly Val Gly Val Lys Ser Glu Pro Gln Pro Ile Ile 
            820                 825                 830         


Ile Gly Arg Arg Asn Glu Val Val Ile Thr Glu Asn Asn Asn Ser Ile 
        835                 840                 845             


Thr Glu Gln Ile Thr Asp Val Val Lys Gln Pro Ala Phe Ile Ala Gly 
    850                 855                 860                 


Ile Gly Gly Ala Cys Trp Val Ile Leu Met Gly Phe Ser Ile Trp Leu 
865                 870                 875                 880 


Tyr Trp Arg Arg Lys Lys Arg Lys Gly Leu Ser Asn Tyr Ala Val Thr 
                885                 890                 895     


Phe Gln Arg Gly Asp Gly Gly Leu Met Ser Asn Gly Ser Arg Pro Gly 
            900                 905                 910         


Leu Leu Asn Ala Gly Asp Pro Ser Tyr Pro Trp Leu Ala Asp Ser Trp 
        915                 920                 925             


Pro Ala Thr Ser Leu Pro Val Asn Asn Ser Asn Ser Gly Pro Asn Glu 
    930                 935                 940                 


Ile Gly Asn Phe Gly Arg Gly Asp Val Leu Pro Pro Val Pro Gly Gln 
945                 950                 955                 960 


Gly Asp Lys Thr Ala Thr Met Leu Ser Asp Gly Ala Ile Tyr Ser Ser 
                965                 970                 975     


Ile Asp Phe Thr Thr Lys Thr Ser Tyr Asn Ser Ser Ser Gln Ile Thr 
            980                 985                 990         


Gln Ala Thr Pro Tyr Ala Thr Thr  Gln Ile Leu His Ser  Asn Ser Ile 
        995                 1000                 1005             


His Glu  Leu Ala Val Asp Leu  Pro Asp Pro Gln Trp  Lys Ser Ser 
    1010                 1015                 1020             


Ile Gln  Gln Lys Thr Asp Leu  Met Gly Phe Gly Tyr  Ser Leu Pro 
    1025                 1030                 1035             


Asp Gln  Asn Lys Gly Asn Asn  Gly Gly Lys Gly Gly  Lys Lys Lys 
    1040                 1045                 1050             


Lys Asn  Lys Asn Ser Ser Lys  Pro Gln Lys Asn Asn  Gly Ser Thr 
    1055                 1060                 1065             


Trp Ala  Asn Val Pro Leu Pro  Pro Pro Pro Val Gln  Pro Leu Pro 
    1070                 1075                 1080             


Gly Thr  Glu Leu Glu His Tyr  Ala Val Glu Gln Gln  Glu Asn Gly 
    1085                 1090                 1095             


Tyr Asp  Ser Asp Ser Trp Cys  Pro Pro Leu Pro Val  Gln Thr Tyr 
    1100                 1105                 1110             


Leu His  Gln Gly Leu Glu Asp  Glu Leu Glu Glu Asp  Asp Asp Arg 
    1115                 1120                 1125             


Val Pro  Thr Pro Pro Val Arg  Gly Val Ala Ser Ser  Pro Ala Ile 
    1130                 1135                 1140             


Ser Phe  Gly Gln Gln Ser Thr  Ala Thr Leu Thr Pro  Ser Pro Arg 
    1145                 1150                 1155             


Glu Glu  Met Gln Pro Met Leu  Gln Ala His Leu Asp  Glu Leu Thr 
    1160                 1165                 1170             


Arg Ala  Tyr Gln Phe Asp Ile  Ala Lys Gln Thr Trp  His Ile Gln 
    1175                 1180                 1185             


Ser Asn  Asn Gln Pro Pro Gln  Pro Pro Val Pro Pro  Leu Gly Tyr 
    1190                 1195                 1200             


Val Ser  Gly Ala Leu Ile Ser  Asp Leu Glu Thr Asp  Val Ala Asp 
    1205                 1210                 1215             


Asp Asp  Ala Asp Asp Glu Glu  Glu Ala Leu Glu Ile  Pro Arg Pro 
    1220                 1225                 1230             


Leu Arg  Ala Leu Asp Gln Thr  Pro Gly Ser Ser Met  Asp Asn Leu 
    1235                 1240                 1245             


Asp Ser  Ser Val Thr Gly Lys  Ala Phe Thr Ser Ser  Gln Arg Pro 
    1250                 1255                 1260             


Arg Pro  Thr Ser Pro Phe Ser  Thr Asp Ser Asn Thr  Ser Ala Ala 
    1265                 1270                 1275             


Leu Ser  Gln Ser Gln Arg Pro  Arg Pro Thr Lys Lys  His Lys Gly 
    1280                 1285                 1290             


Gly Arg  Met Asp Gln Gln Pro  Ala Leu Pro His Arg  Arg Glu Gly 
    1295                 1300                 1305             


Met Thr  Asp Glu Glu Ala Leu  Val Pro Tyr Ser Lys  Pro Ser Phe 
    1310                 1315                 1320             


Pro Ser  Pro Gly Gly His Ser  Ser Ser Gly Thr Ala  Ser Ser Lys 
    1325                 1330                 1335             


Gly Ser  Thr Gly Pro Arg Lys  Thr Glu Val Leu Arg  Ala Gly His 
    1340                 1345                 1350             


Gln Arg  Asn Ala Ser Asp Leu  Leu Asp Ile Gly Tyr  Met Gly Ser 
    1355                 1360                 1365             


Asn Ser  Gln Gly Gln Phe Thr  Gly Glu Leu 
    1370                 1375             


<210>  3
<211>  279
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of Fd chain of AbD32836.1

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly His Ile Lys Ser Lys Thr Asp Gly Gly Ala Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ser Tyr Ser Glu Tyr Ile Pro Leu Tyr Ala Phe Ala 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Glu Phe Gly Gly Ala Pro Gly Lys Pro Ile Pro Asn Pro Leu 
225                 230                 235                 240 


Leu Gly Leu Asp Ser Thr Asp Ala Pro Ser Ala Trp Ser His Pro Gln 
                245                 250                 255     


Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Ala Trp 
            260                 265                 270         


Ser His Pro Gln Phe Glu Lys 
        275                 


<210>  4
<211>  215
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AbD32836.1 Amino acid sequence of light chain

<400>  4

Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Thr Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Tyr Ala Trp Asp Ser Thr Ser 
                85                  90                  95      


Thr Ser Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Ala 
    210                 215 


<210>  5
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy Chain CDRs

<400>  5

Ser Tyr Ala Leu Ser 
1               5   


<210>  6
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy Chain CDRs

<400>  6

His Ile Lys Ser Lys Thr Asp Gly Gly Ala Thr Glu Tyr Ala Ala Pro 
1               5                   10                  15      


Val Lys Gly 
            


<210>  7
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy Chain CDRs

<400>  7

Ser Tyr Ser Glu Tyr Ile Pro Leu Tyr Ala Phe Ala Val 
1               5                   10              


<210>  8
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Light Chain CDR

<400>  8

Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys Tyr Val Ser 
1               5                   10              


<210>  9
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Light Chain CDR

<400>  9

Tyr Thr Ser Gln Arg Pro Ser 
1               5           


<210>  10
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Light Chain CDR

<400>  10

Tyr Ala Trp Asp Ser Thr Ser Thr Ser Thr Val 
1               5                   10      


<210>  11
<211>  103
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CL amino acid sequence

<400>  11

Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
1               5                   10                  15      


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
            20                  25                  30          


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
        35                  40                  45              


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
    50                  55                  60                  


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
65                  70                  75                  80  


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
                85                  90                  95      


Thr Val Ala Pro Thr Glu Ala 
            100             


<210>  12
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CH1 amino acid sequence

<400>  12

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser 
            100         


<210>  13
<211>  2730
<212>  PRT
<213>  Drosophila melanogaster

<400>  13

Met His Pro Met His Pro Glu Asn His Ala Ile Ala Arg Ser Thr Ser 
1               5                   10                  15      


Thr Thr Asn Asn Pro Ser Arg Ser Arg Ser Ser Arg Met Trp Leu Leu 
            20                  25                  30          


Pro Ala Trp Leu Leu Leu Val Leu Val Ala Ser Asn Gly Leu Pro Ala 
        35                  40                  45              


Val Arg Gly Gln Tyr Gln Ser Pro Arg Ile Ile Glu His Pro Thr Asp 
    50                  55                  60                  


Leu Val Val Lys Lys Asn Glu Pro Ala Thr Leu Asn Cys Lys Val Glu 
65                  70                  75                  80  


Gly Lys Pro Glu Pro Thr Ile Glu Trp Phe Lys Asp Gly Glu Pro Val 
                85                  90                  95      


Ser Thr Asn Glu Lys Lys Ser His Arg Val Gln Phe Lys Asp Gly Ala 
            100                 105                 110         


Leu Phe Phe Tyr Arg Thr Met Gln Gly Lys Lys Glu Gln Asp Gly Gly 
        115                 120                 125             


Glu Tyr Trp Cys Val Ala Lys Asn Arg Val Gly Gln Ala Val Ser Arg 
    130                 135                 140                 


His Ala Ser Leu Gln Ile Ala Val Leu Arg Asp Asp Phe Arg Val Glu 
145                 150                 155                 160 


Pro Lys Asp Thr Arg Val Ala Lys Gly Glu Thr Ala Leu Leu Glu Cys 
                165                 170                 175     


Gly Pro Pro Lys Gly Ile Pro Glu Pro Thr Leu Ile Trp Ile Lys Asp 
            180                 185                 190         


Gly Val Pro Leu Asp Asp Leu Lys Ala Met Ser Phe Gly Ala Ser Ser 
        195                 200                 205             


Arg Val Arg Ile Val Asp Gly Gly Asn Leu Leu Ile Ser Asn Val Glu 
    210                 215                 220                 


Pro Ile Asp Glu Gly Asn Tyr Lys Cys Ile Ala Gln Asn Leu Val Gly 
225                 230                 235                 240 


Thr Arg Glu Ser Ser Tyr Ala Lys Leu Ile Val Gln Val Lys Pro Tyr 
                245                 250                 255     


Phe Met Lys Glu Pro Lys Asp Gln Val Met Leu Tyr Gly Gln Thr Ala 
            260                 265                 270         


Thr Phe His Cys Ser Val Gly Gly Asp Pro Pro Pro Lys Val Leu Trp 
        275                 280                 285             


Lys Lys Glu Glu Gly Asn Ile Pro Val Ser Arg Ala Arg Ile Leu His 
    290                 295                 300                 


Asp Glu Lys Ser Leu Glu Ile Ser Asn Ile Thr Pro Thr Asp Glu Gly 
305                 310                 315                 320 


Thr Tyr Val Cys Glu Ala His Asn Asn Val Gly Gln Ile Ser Ala Arg 
                325                 330                 335     


Ala Ser Leu Ile Val His Ala Pro Pro Asn Phe Thr Lys Arg Pro Ser 
            340                 345                 350         


Asn Lys Lys Val Gly Leu Asn Gly Val Val Gln Leu Pro Cys Met Ala 
        355                 360                 365             


Ser Gly Asn Pro Pro Pro Ser Val Phe Trp Thr Lys Glu Gly Val Ser 
    370                 375                 380                 


Thr Leu Met Phe Pro Asn Ser Ser His Gly Arg Gln Tyr Val Ala Ala 
385                 390                 395                 400 


Asp Gly Thr Leu Gln Ile Thr Asp Val Arg Gln Glu Asp Glu Gly Tyr 
                405                 410                 415     


Tyr Val Cys Ser Ala Phe Ser Val Val Asp Ser Ser Thr Val Arg Val 
            420                 425                 430         


Phe Leu Gln Val Ser Ser Val Asp Glu Arg Pro Pro Pro Ile Ile Gln 
        435                 440                 445             


Ile Gly Pro Ala Asn Gln Thr Leu Pro Lys Gly Ser Val Ala Thr Leu 
    450                 455                 460                 


Pro Cys Arg Ala Thr Gly Asn Pro Ser Pro Arg Ile Lys Trp Phe His 
465                 470                 475                 480 


Asp Gly His Ala Val Gln Ala Gly Asn Arg Tyr Ser Ile Ile Gln Gly 
                485                 490                 495     


Ser Ser Leu Arg Val Asp Asp Leu Gln Leu Ser Asp Ser Gly Thr Tyr 
            500                 505                 510         


Thr Cys Thr Ala Ser Gly Glu Arg Gly Glu Thr Ser Trp Ala Ala Thr 
        515                 520                 525             


Leu Thr Val Glu Lys Pro Gly Ser Thr Ser Leu His Arg Ala Ala Asp 
    530                 535                 540                 


Pro Ser Thr Tyr Pro Ala Pro Pro Gly Thr Pro Lys Val Leu Asn Val 
545                 550                 555                 560 


Ser Arg Thr Ser Ile Ser Leu Arg Trp Ala Lys Ser Gln Glu Lys Pro 
                565                 570                 575     


Gly Ala Val Gly Pro Ile Ile Gly Tyr Thr Val Glu Tyr Phe Ser Pro 
            580                 585                 590         


Asp Leu Gln Thr Gly Trp Ile Val Ala Ala His Arg Val Gly Asp Thr 
        595                 600                 605             


Gln Val Thr Ile Ser Gly Leu Thr Pro Gly Thr Ser Tyr Val Phe Leu 
    610                 615                 620                 


Val Arg Ala Glu Asn Thr Gln Gly Ile Ser Val Pro Ser Gly Leu Ser 
625                 630                 635                 640 


Asn Val Ile Lys Thr Ile Glu Ala Asp Phe Asp Ala Ala Ser Ala Asn 
                645                 650                 655     


Asp Leu Ser Ala Ala Arg Thr Leu Leu Thr Gly Lys Ser Val Glu Leu 
            660                 665                 670         


Ile Asp Ala Ser Ala Ile Asn Ala Ser Ala Val Arg Leu Glu Trp Met 
        675                 680                 685             


Leu His Val Ser Ala Asp Glu Lys Tyr Val Glu Gly Leu Arg Ile His 
    690                 695                 700                 


Tyr Lys Asp Ala Ser Val Pro Ser Ala Gln Tyr His Ser Ile Thr Val 
705                 710                 715                 720 


Met Asp Ala Ser Ala Glu Ser Phe Val Val Gly Asn Leu Lys Lys Tyr 
                725                 730                 735     


Thr Lys Tyr Glu Phe Phe Leu Thr Pro Phe Phe Glu Thr Ile Glu Gly 
            740                 745                 750         


Gln Pro Ser Asn Ser Lys Thr Ala Leu Thr Tyr Glu Asp Val Pro Ser 
        755                 760                 765             


Ala Pro Pro Asp Asn Ile Gln Ile Gly Met Tyr Asn Gln Thr Ala Gly 
    770                 775                 780                 


Trp Val Arg Trp Thr Pro Pro Pro Ser Gln His His Asn Gly Asn Leu 
785                 790                 795                 800 


Tyr Gly Tyr Lys Ile Glu Val Ser Ala Gly Asn Thr Met Lys Val Leu 
                805                 810                 815     


Ala Asn Met Thr Leu Asn Ala Thr Thr Thr Ser Val Leu Leu Asn Asn 
            820                 825                 830         


Leu Thr Thr Gly Ala Val Tyr Ser Val Arg Leu Asn Ser Phe Thr Lys 
        835                 840                 845             


Ala Gly Asp Gly Pro Tyr Ser Lys Pro Ile Ser Leu Phe Met Asp Pro 
    850                 855                 860                 


Thr His His Val His Pro Pro Arg Ala His Pro Ser Gly Thr His Asp 
865                 870                 875                 880 


Gly Arg His Glu Gly Gln Asp Leu Thr Tyr His Asn Asn Gly Asn Ile 
                885                 890                 895     


Pro Pro Gly Asp Ile Asn Pro Thr Thr His Lys Lys Thr Thr Asp Tyr 
            900                 905                 910         


Leu Ser Gly Pro Trp Leu Met Val Leu Val Cys Ile Val Leu Leu Val 
        915                 920                 925             


Leu Val Ile Ser Ala Ala Ile Ser Met Val Tyr Phe Lys Arg Lys His 
    930                 935                 940                 


Gln Met Thr Lys Glu Leu Gly His Leu Ser Val Val Ser Asp Asn Glu 
945                 950                 955                 960 


Ile Thr Ala Leu Asn Ile Asn Ser Lys Glu Ser Leu Trp Ile Asp His 
                965                 970                 975     


His Arg Gly Trp Arg Thr Ala Asp Thr Asp Lys Asp Ser Gly Leu Ser 
            980                 985                 990         


Glu Ser Lys Leu Leu Ser His Val  Asn Ser Ser Gln Ser  Asn Tyr Asn 
        995                 1000                 1005             


Asn Ser  Asp Gly Gly Thr Asp  Tyr Ala Glu Val Asp  Thr Arg Asn 
    1010                 1015                 1020             


Leu Thr  Thr Phe Tyr Asn Cys  Arg Lys Ser Pro Asp  Asn Pro Thr 
    1025                 1030                 1035             


Pro Tyr  Ala Thr Thr Met Ile  Ile Gly Thr Ser Ser  Ser Glu Thr 
    1040                 1045                 1050             


Cys Thr  Lys Thr Thr Ser Ile  Ser Ala Asp Lys Asp  Ser Gly Thr 
    1055                 1060                 1065             


His Ser  Pro Tyr Ser Asp Ala  Phe Ala Gly Gln Val  Pro Ala Val 
    1070                 1075                 1080             


Pro Val  Val Lys Ser Asn Tyr  Leu Gln Tyr Pro Val  Glu Pro Ile 
    1085                 1090                 1095             


Asn Trp  Ser Glu Phe Leu Pro  Pro Pro Pro Glu His  Pro Pro Pro 
    1100                 1105                 1110             


Ser Ser  Thr Tyr Gly Tyr Ala  Gln Gly Ser Pro Glu  Ser Ser Arg 
    1115                 1120                 1125             


Lys Ser  Ser Lys Ser Ala Gly  Ser Gly Ile Ser Thr  Asn Gln Ser 
    1130                 1135                 1140             


Ile Leu  Asn Ala Ser Ile His  Ser Ser Ser Ser Gly  Gly Phe Ser 
    1145                 1150                 1155             


Ala Trp  Gly Val Ser Pro Gln  Tyr Ala Val Ala Cys  Pro Pro Glu 
    1160                 1165                 1170             


Asn Val  Tyr Ser Asn Pro Leu  Ser Ala Val Ala Gly  Gly Thr Gln 
    1175                 1180                 1185             


Asn Arg  Tyr Gln Ile Thr Pro  Thr Asn Gln His Pro  Pro Gln Leu 
    1190                 1195                 1200             


Pro Ala  Tyr Phe Ala Thr Thr  Gly Pro Gly Gly Ala  Val Pro Pro 
    1205                 1210                 1215             


Asn His  Leu Pro Phe Ala Thr  Gln Arg His Ala Ala  Ser Glu Tyr 
    1220                 1225                 1230             


Gln Ala  Gly Leu Asn Ala Ala  Arg Cys Ala Gln Ser  Arg Ala Cys 
    1235                 1240                 1245             


Asn Ser  Cys Asp Ala Leu Ala  Thr Pro Ser Pro Met  Gln Pro Pro 
    1250                 1255                 1260             


Pro Pro  Val Pro Val Pro Glu  Gly Trp Tyr Gln Pro  Val His Pro 
    1265                 1270                 1275             


Asn Ser  His Pro Met His Pro  Thr Ser Ser Asn His  Gln Ile Tyr 
    1280                 1285                 1290             


Gln Cys  Ser Ser Glu Cys Ser  Asp His Ser Arg Ser  Ser Gln Ser 
    1295                 1300                 1305             


His Lys  Arg Gln Leu Gln Leu  Glu Glu His Gly Ser  Ser Ala Lys 
    1310                 1315                 1320             


Gln Arg  Gly Gly His His Arg  Arg Arg Ala Pro Val  Val Gln Pro 
    1325                 1330                 1335             


Cys Met  Glu Ser Glu Asn Glu  Asn Met Leu Ala Glu  Tyr Glu Gln 
    1340                 1345                 1350             


Arg Gln  Tyr Thr Ser Asp Cys  Cys Asn Ser Ser Arg  Glu Gly Asp 
    1355                 1360                 1365             


Thr Cys  Ser Cys Ser Glu Gly  Ser Cys Leu Tyr Ala  Glu Ala Gly 
    1370                 1375                 1380             


Glu Pro  Ala Pro Arg Gln Met  Thr Ala Lys Asn Thr  His Pro Thr 
    1385                 1390                 1395             


Asp Leu  Val Val Lys Lys Asn  Glu Pro Ala Thr Leu  Asn Cys Lys 
    1400                 1405                 1410             


Val Glu  Gly Lys Pro Glu Pro  Thr Ile Glu Trp Phe  Lys Asp Gly 
    1415                 1420                 1425             


Glu Pro  Val Ser Thr Asn Glu  Lys Lys Ser His Arg  Val Gln Phe 
    1430                 1435                 1440             


Lys Asp  Gly Ala Leu Phe Phe  Tyr Arg Thr Met Gln  Gly Lys Lys 
    1445                 1450                 1455             


Glu Gln  Asp Gly Gly Glu Tyr  Trp Cys Val Ala Lys  Asn Arg Val 
    1460                 1465                 1470             


Gly Gln  Ala Val Ser Arg His  Ala Ser Leu Gln Ile  Ala Val Leu 
    1475                 1480                 1485             


Arg Asp  Asp Phe Arg Val Glu  Pro Lys Asp Thr Arg  Val Ala Lys 
    1490                 1495                 1500             


Gly Glu  Thr Ala Leu Leu Glu  Cys Gly Pro Pro Lys  Gly Ile Pro 
    1505                 1510                 1515             


Glu Pro  Thr Leu Ile Trp Ile  Lys Asp Gly Val Pro  Leu Asp Asp 
    1520                 1525                 1530             


Leu Lys  Ala Met Ser Phe Gly  Ala Ser Ser Arg Val  Arg Ile Val 
    1535                 1540                 1545             


Asp Gly  Gly Asn Leu Leu Ile  Ser Asn Val Glu Pro  Ile Asp Glu 
    1550                 1555                 1560             


Gly Asn  Tyr Lys Cys Ile Ala  Gln Asn Leu Val Gly  Thr Arg Glu 
    1565                 1570                 1575             


Ser Ser  Tyr Ala Lys Leu Ile  Val Gln Val Lys Pro  Tyr Phe Met 
    1580                 1585                 1590             


Lys Glu  Pro Lys Asp Gln Val  Met Leu Tyr Gly Gln  Thr Ala Thr 
    1595                 1600                 1605             


Phe His  Cys Ser Val Gly Gly  Asp Pro Pro Pro Lys  Val Leu Trp 
    1610                 1615                 1620             


Lys Lys  Glu Glu Gly Asn Ile  Pro Val Ser Arg Ala  Arg Ile Leu 
    1625                 1630                 1635             


His Asp  Glu Lys Ser Leu Glu  Ile Ser Asn Ile Thr  Pro Thr Asp 
    1640                 1645                 1650             


Glu Gly  Thr Tyr Val Cys Glu  Ala His Asn Asn Val  Gly Gln Ile 
    1655                 1660                 1665             


Ser Ala  Arg Ala Ser Leu Ile  Val His Ala Pro Pro  Asn Phe Thr 
    1670                 1675                 1680             


Lys Arg  Pro Ser Asn Lys Lys  Val Gly Leu Asn Gly  Val Val Gln 
    1685                 1690                 1695             


Leu Pro  Cys Met Ala Ser Gly  Asn Pro Pro Pro Ser  Val Phe Trp 
    1700                 1705                 1710             


Thr Lys  Glu Gly Val Ser Thr  Leu Met Phe Pro Asn  Ser Ser His 
    1715                 1720                 1725             


Gly Arg  Gln Tyr Val Ala Ala  Asp Gly Thr Leu Gln  Ile Thr Asp 
    1730                 1735                 1740             


Val Arg  Gln Glu Asp Glu Gly  Tyr Tyr Val Cys Ser  Ala Phe Ser 
    1745                 1750                 1755             


Val Val  Asp Ser Ser Thr Val  Arg Val Phe Leu Gln  Val Ser Ser 
    1760                 1765                 1770             


Val Asp  Glu Arg Pro Pro Pro  Ile Ile Gln Ile Gly  Pro Ala Asn 
    1775                 1780                 1785             


Gln Thr  Leu Pro Lys Gly Ser  Val Ala Thr Leu Pro  Cys Arg Ala 
    1790                 1795                 1800             


Thr Gly  Asn Pro Ser Pro Arg  Ile Lys Trp Phe His  Asp Gly His 
    1805                 1810                 1815             


Ala Val  Gln Ala Gly Asn Arg  Tyr Ser Ile Ile Gln  Gly Ser Ser 
    1820                 1825                 1830             


Leu Arg  Val Asp Asp Leu Gln  Leu Ser Asp Ser Gly  Thr Tyr Thr 
    1835                 1840                 1845             


Cys Thr  Ala Ser Gly Glu Arg  Gly Glu Thr Ser Trp  Ala Ala Thr 
    1850                 1855                 1860             


Leu Thr  Val Glu Lys Pro Gly  Ser Thr Ser Leu His  Arg Ala Ala 
    1865                 1870                 1875             


Asp Pro  Ser Thr Tyr Pro Ala  Pro Pro Gly Thr Pro  Lys Val Leu 
    1880                 1885                 1890             


Asn Val  Ser Arg Thr Ser Ile  Ser Leu Arg Trp Ala  Lys Ser Gln 
    1895                 1900                 1905             


Glu Lys  Pro Gly Ala Val Gly  Pro Ile Ile Gly Tyr  Thr Val Glu 
    1910                 1915                 1920             


Tyr Phe  Ser Pro Asp Leu Gln  Thr Gly Trp Ile Val  Ala Ala His 
    1925                 1930                 1935             


Arg Val  Gly Asp Thr Gln Val  Thr Ile Ser Gly Leu  Thr Pro Gly 
    1940                 1945                 1950             


Thr Ser  Tyr Val Phe Leu Val  Arg Ala Glu Asn Thr  Gln Gly Ile 
    1955                 1960                 1965             


Ser Val  Pro Ser Gly Leu Ser  Asn Val Ile Lys Thr  Ile Glu Ala 
    1970                 1975                 1980             


Asp Phe  Asp Ala Ala Ser Ala  Asn Asp Leu Ser Ala  Ala Arg Thr 
    1985                 1990                 1995             


Leu Leu  Thr Gly Lys Ser Val  Glu Leu Ile Asp Ala  Ser Ala Ile 
    2000                 2005                 2010             


Asn Ala  Ser Ala Val Arg Leu  Glu Trp Met Leu His  Val Ser Ala 
    2015                 2020                 2025             


Asp Glu  Lys Tyr Val Glu Gly  Leu Arg Ile His Tyr  Lys Asp Ala 
    2030                 2035                 2040             


Ser Val  Pro Ser Ala Gln Tyr  His Ser Ile Thr Val  Met Asp Ala 
    2045                 2050                 2055             


Ser Ala  Glu Ser Phe Val Val  Gly Asn Leu Lys Lys  Tyr Thr Lys 
    2060                 2065                 2070             


Tyr Glu  Phe Phe Leu Thr Pro  Phe Phe Glu Thr Ile  Glu Gly Gln 
    2075                 2080                 2085             


Pro Ser  Asn Ser Lys Thr Ala  Leu Thr Tyr Glu Asp  Val Pro Ser 
    2090                 2095                 2100             


Ala Pro  Pro Asp Asn Ile Gln  Ile Gly Met Tyr Asn  Gln Thr Ala 
    2105                 2110                 2115             


Gly Trp  Val Arg Trp Thr Pro  Pro Pro Ser Gln His  His Asn Gly 
    2120                 2125                 2130             


Asn Leu  Tyr Gly Tyr Lys Ile  Glu Val Ser Ala Gly  Asn Thr Met 
    2135                 2140                 2145             


Lys Val  Leu Ala Asn Met Thr  Leu Asn Ala Thr Thr  Thr Ser Val 
    2150                 2155                 2160             


Leu Leu  Asn Asn Leu Thr Thr  Gly Ala Val Tyr Ser  Val Arg Leu 
    2165                 2170                 2175             


Asn Ser  Phe Thr Lys Ala Gly  Asp Gly Pro Tyr Ser  Lys Pro Ile 
    2180                 2185                 2190             


Ser Leu  Phe Met Asp Pro Thr  His His Val His Pro  Pro Arg Ala 
    2195                 2200                 2205             


His Pro  Ser Gly Thr His Asp  Gly Arg His Glu Gly  Gln Asp Leu 
    2210                 2215                 2220             


Thr Tyr  His Asn Asn Gly Asn  Ile Pro Pro Gly Asp  Ile Asn Pro 
    2225                 2230                 2235             


Thr Thr  His Lys Lys Thr Thr  Asp Tyr Leu Ser Gly  Pro Trp Leu 
    2240                 2245                 2250             


Met Val  Leu Val Cys Ile Val  Leu Leu Val Leu Val  Ile Ser Ala 
    2255                 2260                 2265             


Ala Ile  Ser Met Val Tyr Phe  Lys Arg Lys His Gln  Met Thr Lys 
    2270                 2275                 2280             


Glu Leu  Gly His Leu Ser Val  Val Ser Asp Asn Glu  Ile Thr Ala 
    2285                 2290                 2295             


Leu Asn  Ile Asn Ser Lys Glu  Ser Leu Trp Ile Asp  His His Arg 
    2300                 2305                 2310             


Gly Trp  Arg Thr Ala Asp Thr  Asp Lys Asp Ser Gly  Leu Ser Glu 
    2315                 2320                 2325             


Ser Lys  Leu Leu Ser His Val  Asn Ser Ser Gln Ser  Asn Tyr Asn 
    2330                 2335                 2340             


Asn Ser  Asp Gly Gly Thr Asp  Tyr Ala Glu Val Asp  Thr Arg Asn 
    2345                 2350                 2355             


Leu Thr  Thr Phe Tyr Asn Cys  Arg Lys Ser Pro Asp  Asn Pro Thr 
    2360                 2365                 2370             


Pro Tyr  Ala Thr Thr Met Ile  Ile Gly Thr Ser Ser  Ser Glu Thr 
    2375                 2380                 2385             


Cys Thr  Lys Thr Thr Ser Ile  Ser Ala Asp Lys Asp  Ser Gly Thr 
    2390                 2395                 2400             


His Ser  Pro Tyr Ser Asp Ala  Phe Ala Gly Gln Val  Pro Ala Val 
    2405                 2410                 2415             


Pro Val  Val Lys Ser Asn Tyr  Leu Gln Tyr Pro Val  Glu Pro Ile 
    2420                 2425                 2430             


Asn Trp  Ser Glu Phe Leu Pro  Pro Pro Pro Glu His  Pro Pro Pro 
    2435                 2440                 2445             


Ser Ser  Thr Tyr Gly Tyr Ala  Gln Gly Ser Pro Glu  Ser Ser Arg 
    2450                 2455                 2460             


Lys Ser  Ser Lys Ser Ala Gly  Ser Gly Ile Ser Thr  Asn Gln Ser 
    2465                 2470                 2475             


Ile Leu  Asn Ala Ser Ile His  Ser Ser Ser Ser Gly  Gly Phe Ser 
    2480                 2485                 2490             


Ala Trp  Gly Val Ser Pro Gln  Tyr Ala Val Ala Cys  Pro Pro Glu 
    2495                 2500                 2505             


Asn Val  Tyr Ser Asn Pro Leu  Ser Ala Val Ala Gly  Gly Thr Gln 
    2510                 2515                 2520             


Asn Arg  Tyr Gln Ile Thr Pro  Thr Asn Gln His Pro  Pro Gln Leu 
    2525                 2530                 2535             


Pro Ala  Tyr Phe Ala Thr Thr  Gly Pro Gly Gly Ala  Val Pro Pro 
    2540                 2545                 2550             


Asn His  Leu Pro Phe Ala Thr  Gln Arg His Ala Ala  Ser Glu Tyr 
    2555                 2560                 2565             


Gln Ala  Gly Leu Asn Ala Ala  Arg Cys Ala Gln Ser  Arg Ala Cys 
    2570                 2575                 2580             


Asn Ser  Cys Asp Ala Leu Ala  Thr Pro Ser Pro Met  Gln Pro Pro 
    2585                 2590                 2595             


Pro Pro  Val Pro Val Pro Glu  Gly Trp Tyr Gln Pro  Val His Pro 
    2600                 2605                 2610             


Asn Ser  His Pro Met His Pro  Thr Ser Ser Asn His  Gln Ile Tyr 
    2615                 2620                 2625             


Gln Cys  Ser Ser Glu Cys Ser  Asp His Ser Arg Ser  Ser Gln Ser 
    2630                 2635                 2640             


His Lys  Arg Gln Leu Gln Leu  Glu Glu His Gly Ser  Ser Ala Lys 
    2645                 2650                 2655             


Gln Arg  Gly Gly His His Arg  Arg Arg Ala Pro Val  Val Gln Pro 
    2660                 2665                 2670             


Cys Met  Glu Ser Glu Asn Glu  Asn Met Leu Ala Glu  Tyr Glu Gln 
    2675                 2680                 2685             


Arg Gln  Tyr Thr Ser Asp Cys  Cys Asn Ser Ser Arg  Glu Gly Asp 
    2690                 2695                 2700             


Thr Cys  Ser Cys Ser Glu Gly  Ser Cys Leu Tyr Ala  Glu Ala Gly 
    2705                 2710                 2715             


Glu Pro  Ala Pro Arg Gln Met  Thr Ala Lys Asn Thr  
    2720                 2725                 2730 


<210>  14
<211>  1273
<212>  PRT
<213>  Caenorhabditis elegans

<400>  14

Met Phe Asn Arg Lys Thr Leu Leu Cys Thr Ile Leu Leu Val Leu Gln 
1               5                   10                  15      


Ala Val Ile Arg Ser Phe Cys Glu Asp Ala Ser Asn Leu Ala Pro Val 
            20                  25                  30          


Ile Ile Glu His Pro Ile Asp Val Val Val Ser Arg Gly Ser Pro Ala 
        35                  40                  45              


Thr Leu Asn Cys Gly Ala Lys Pro Ser Thr Ala Lys Ile Thr Trp Tyr 
    50                  55                  60                  


Lys Asp Gly Gln Pro Val Ile Thr Asn Lys Glu Gln Val Asn Ser His 
65                  70                  75                  80  


Arg Ile Val Leu Asp Thr Gly Ser Leu Phe Leu Leu Lys Val Asn Ser 
                85                  90                  95      


Gly Lys Asn Gly Lys Asp Ser Asp Ala Gly Ala Tyr Tyr Cys Val Ala 
            100                 105                 110         


Ser Asn Glu His Gly Glu Val Lys Ser Asn Glu Gly Ser Leu Lys Leu 
        115                 120                 125             


Ala Met Leu Arg Glu Asp Phe Arg Val Arg Pro Arg Thr Val Gln Ala 
    130                 135                 140                 


Leu Gly Gly Glu Met Ala Val Leu Glu Cys Ser Pro Pro Arg Gly Phe 
145                 150                 155                 160 


Pro Glu Pro Val Val Ser Trp Arg Lys Asp Asp Lys Glu Leu Arg Ile 
                165                 170                 175     


Gln Asp Met Pro Arg Tyr Thr Leu His Ser Asp Gly Asn Leu Ile Ile 
            180                 185                 190         


Asp Pro Val Asp Arg Ser Asp Ser Gly Thr Tyr Gln Cys Val Ala Asn 
        195                 200                 205             


Asn Met Val Gly Glu Arg Val Ser Asn Pro Ala Arg Leu Ser Val Phe 
    210                 215                 220                 


Glu Lys Pro Lys Phe Glu Gln Glu Pro Lys Asp Met Thr Val Asp Val 
225                 230                 235                 240 


Gly Ala Ala Val Leu Phe Asp Cys Arg Val Thr Gly Asp Pro Gln Pro 
                245                 250                 255     


Gln Ile Thr Trp Lys Arg Lys Asn Glu Pro Met Pro Val Thr Arg Ala 
            260                 265                 270         


Tyr Ile Ala Lys Asp Asn Arg Gly Leu Arg Ile Glu Arg Val Gln Pro 
        275                 280                 285             


Ser Asp Glu Gly Glu Tyr Val Cys Tyr Ala Arg Asn Pro Ala Gly Thr 
    290                 295                 300                 


Leu Glu Ala Ser Ala His Leu Arg Val Gln Ala Pro Pro Ser Phe Gln 
305                 310                 315                 320 


Thr Lys Pro Ala Asp Gln Ser Val Pro Ala Gly Gly Thr Ala Thr Phe 
                325                 330                 335     


Glu Cys Thr Leu Val Gly Gln Pro Ser Pro Ala Tyr Phe Trp Ser Lys 
            340                 345                 350         


Glu Gly Gln Gln Asp Leu Leu Phe Pro Ser Tyr Val Ser Ala Asp Gly 
        355                 360                 365             


Arg Thr Lys Val Ser Pro Thr Gly Thr Leu Thr Ile Glu Glu Val Arg 
    370                 375                 380                 


Gln Val Asp Glu Gly Ala Tyr Val Cys Ala Gly Met Asn Ser Ala Gly 
385                 390                 395                 400 


Ser Ser Leu Ser Lys Ala Ala Leu Lys Val Thr Thr Lys Ala Val Thr 
                405                 410                 415     


Gly Asn Thr Pro Ala Lys Pro Pro Pro Thr Ile Glu His Gly His Gln 
            420                 425                 430         


Asn Gln Thr Leu Met Val Gly Ser Ser Ala Ile Leu Pro Cys Gln Ala 
        435                 440                 445             


Ser Gly Lys Pro Thr Pro Gly Ile Ser Trp Leu Arg Asp Gly Leu Pro 
    450                 455                 460                 


Ile Asp Ile Thr Asp Ser Arg Ile Ser Gln His Ser Thr Gly Ser Leu 
465                 470                 475                 480 


His Ile Ala Asp Leu Lys Lys Pro Asp Thr Gly Val Tyr Thr Cys Ile 
                485                 490                 495     


Ala Lys Asn Glu Asp Gly Glu Ser Thr Trp Ser Ala Ser Leu Thr Val 
            500                 505                 510         


Glu Asp His Thr Ser Asn Ala Gln Phe Val Arg Met Pro Asp Pro Ser 
        515                 520                 525             


Asn Phe Pro Ser Ser Pro Thr Gln Pro Ile Ile Val Asn Val Thr Asp 
    530                 535                 540                 


Thr Glu Val Glu Leu His Trp Asn Ala Pro Ser Thr Ser Gly Ala Gly 
545                 550                 555                 560 


Pro Ile Thr Gly Tyr Ile Ile Gln Tyr Tyr Ser Pro Asp Leu Gly Gln 
                565                 570                 575     


Thr Trp Phe Asn Ile Pro Asp Tyr Val Ala Ser Thr Glu Tyr Arg Ile 
            580                 585                 590         


Lys Gly Leu Lys Pro Ser His Ser Tyr Met Phe Val Ile Arg Ala Glu 
        595                 600                 605             


Asn Glu Lys Gly Ile Gly Thr Pro Ser Val Ser Ser Ala Leu Val Thr 
    610                 615                 620                 


Thr Ser Lys Pro Ala Ala Gln Val Ala Leu Ser Asp Lys Asn Lys Met 
625                 630                 635                 640 


Asp Met Ala Ile Ala Glu Lys Arg Leu Thr Ser Glu Gln Leu Ile Lys 
                645                 650                 655     


Leu Glu Glu Val Lys Thr Ile Asn Ser Thr Ala Val Arg Leu Phe Trp 
            660                 665                 670         


Lys Lys Arg Lys Leu Glu Glu Leu Ile Asp Gly Tyr Tyr Ile Lys Trp 
        675                 680                 685             


Arg Gly Pro Pro Arg Thr Asn Asp Asn Gln Tyr Val Asn Val Thr Ser 
    690                 695                 700                 


Pro Ser Thr Glu Asn Tyr Val Val Ser Asn Leu Met Pro Phe Thr Asn 
705                 710                 715                 720 


Tyr Glu Phe Phe Val Ile Pro Tyr His Ser Gly Val His Ser Ile His 
                725                 730                 735     


Gly Ala Pro Ser Asn Ser Met Asp Val Leu Thr Ala Glu Ala Pro Pro 
            740                 745                 750         


Ser Leu Pro Pro Glu Asp Val Arg Ile Arg Met Leu Asn Leu Thr Thr 
        755                 760                 765             


Leu Arg Ile Ser Trp Lys Ala Pro Lys Ala Asp Gly Ile Asn Gly Ile 
    770                 775                 780                 


Leu Lys Gly Phe Gln Ile Val Ile Val Gly Gln Ala Pro Asn Asn Asn 
785                 790                 795                 800 


Arg Asn Ile Thr Thr Asn Glu Arg Ala Ala Ser Val Thr Leu Phe His 
                805                 810                 815     


Leu Val Thr Gly Met Thr Tyr Lys Ile Arg Val Ala Ala Arg Ser Asn 
            820                 825                 830         


Gly Gly Val Gly Val Ser His Gly Thr Ser Glu Val Ile Met Asn Gln 
        835                 840                 845             


Asp Thr Leu Glu Lys His Leu Ala Ala Gln Gln Glu Asn Glu Ser Phe 
    850                 855                 860                 


Leu Tyr Gly Leu Ile Asn Lys Ser His Val Pro Val Ile Val Ile Val 
865                 870                 875                 880 


Ala Ile Leu Ile Ile Phe Val Val Ile Ile Ile Ala Tyr Cys Tyr Trp 
                885                 890                 895     


Arg Asn Ser Arg Asn Ser Asp Gly Lys Asp Arg Ser Phe Ile Lys Ile 
            900                 905                 910         


Asn Asp Gly Ser Val His Met Ala Ser Asn Asn Leu Trp Asp Val Ala 
        915                 920                 925             


Gln Asn Pro Asn Gln Asn Pro Met Tyr Asn Thr Ala Gly Arg Met Thr 
    930                 935                 940                 


Met Asn Asn Arg Asn Gly Gln Ala Leu Tyr Ser Leu Thr Pro Asn Ala 
945                 950                 955                 960 


Gln Asp Phe Phe Asn Asn Cys Asp Asp Tyr Ser Gly Thr Met His Arg 
                965                 970                 975     


Pro Gly Ser Glu His His Tyr His Tyr Ala Gln Leu Thr Gly Gly Pro 
            980                 985                 990         


Gly Asn Ala Met Ser Thr Phe Tyr  Gly Asn Gln Tyr His  Asp Asp Pro 
        995                 1000                 1005             


Ser Pro  Tyr Ala Thr Thr Thr  Leu Val Leu Ser Asn  Gln Gln Pro 
    1010                 1015                 1020             


Ala Trp  Leu Asn Asp Lys Met  Leu Arg Ala Pro Ala  Met Pro Thr 
    1025                 1030                 1035             


Asn Pro  Val Pro Pro Glu Pro  Pro Ala Arg Tyr Ala  Asp His Thr 
    1040                 1045                 1050             


Ala Gly  Arg Arg Ser Arg Ser  Ser Arg Ala Ser Asp  Gly Arg Gly 
    1055                 1060                 1065             


Thr Leu  Asn Gly Gly Leu His  His Arg Thr Ser Gly  Ser Gln Arg 
    1070                 1075                 1080             


Ser Asp  Ser Pro Pro His Thr  Asp Val Ser Tyr Val  Gln Leu His 
    1085                 1090                 1095             


Ser Ser  Asp Gly Thr Gly Ser  Ser Lys Glu Arg Thr  Gly Glu Arg 
    1100                 1105                 1110             


Arg Thr  Pro Pro Asn Lys Thr  Leu Met Asp Phe Ile  Pro Pro Pro 
    1115                 1120                 1125             


Pro Ser  Asn Pro Pro Pro Pro  Gly Gly His Val Tyr  Asp Asp Ile 
    1130                 1135                 1140             


Phe Gln  Thr Ala Thr Arg Arg  Gln Leu Asn Arg Gly  Ser Thr Pro 
    1145                 1150                 1155             


Arg Glu  Asp Thr Tyr Asp Ser  Val Ser Asp Gly Ala  Phe Ala Arg 
    1160                 1165                 1170             


Val Asp  Val Asn Ala Arg Pro  Thr Ser Arg Asn Arg  Asn Leu Gly 
    1175                 1180                 1185             


Gly Arg  Pro Leu Lys Gly Lys  Arg Asp Asp Asp Ser  Gln Arg Ser 
    1190                 1195                 1200             


Ser Leu  Met Met Asp Asp Asp  Gly Gly Ser Ser Glu  Ala Asp Gly 
    1205                 1210                 1215             


Glu Asn  Ser Glu Gly Asp Val  Pro Arg Gly Gly Val  Arg Lys Ala 
    1220                 1225                 1230             


Val Pro  Arg Met Gly Ile Ser  Ala Ser Thr Leu Ala  His Ser Cys 
    1235                 1240                 1245             


Tyr Gly  Thr Asn Gly Thr Ala  Gln Arg Phe Arg Ser  Ile Pro Arg 
    1250                 1255                 1260             


Asn Asn  Gly Ile Val Thr Gln  Glu Gln Thr 
    1265                 1270             


<210>  15
<211>  1525
<212>  PRT
<213>  Exaiptasia pallida


<220>
<221>  misc_feature
<222>  (387)..(387)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (791)..(791)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Met Val Tyr Trp Glu Lys Leu Val Cys Leu Leu Leu Val Val Ile Val 
1               5                   10                  15      


Asn Tyr Gln His Cys Ser Ala Asp Ser Leu Pro Gln Ile Ile Glu His 
            20                  25                  30          


Pro Glu Asp Val Ile Ala Ala Lys Asn Ser Asn Thr Glu Leu Arg Cys 
        35                  40                  45              


Lys Ala Thr Gly Ser Pro Lys Pro Ile Ile His Trp Leu Arg Asn Gly 
    50                  55                  60                  


Lys Lys Val Pro Thr Asp Glu Asp Asp Pro Glu Lys Arg Arg Tyr Ile 
65                  70                  75                  80  


Leu Pro Ser Gly Asn Leu Thr Phe Ile Arg Val Ile Gln Lys Lys Lys 
                85                  90                  95      


Arg Thr Asp Ser Gly Lys Tyr Gln Cys Val Ala Val Asn Lys Val Gly 
            100                 105                 110         


Lys Thr Thr Ser Lys Ala Ala Thr Leu Leu Val Gly Val Leu Arg Ser 
        115                 120                 125             


Gln Phe Lys Thr Glu Pro Arg Asp Arg Thr Val Thr Ala Gly Asn Pro 
    130                 135                 140                 


Val Thr Leu Lys Cys Asn Pro Pro Arg Gly Lys Pro Ser Pro Lys Val 
145                 150                 155                 160 


Ser Trp Ile Lys Asp Gly Val Met Val Lys Pro Asp Gly Lys Arg Val 
                165                 170                 175     


Leu Ile Lys Glu Pro Gly Ser Leu Tyr Ile Ser Ala Ala Arg Lys Val 
            180                 185                 190         


Asp Gln Gly Lys Tyr Val Cys Leu Ala Thr Asn Pro Leu Gly Gln Lys 
        195                 200                 205             


Lys Ser Asn Thr Ala Arg Leu Thr Val Lys Glu Leu Pro Ala Thr Ala 
    210                 215                 220                 


Leu Arg Ile Arg Pro Ala Gln Lys Thr Val Ser Ala Gly Ser Ser Val 
225                 230                 235                 240 


Thr Phe Gln Cys Asp Tyr Arg Asp Gly Pro Gln Gly Ala Ile Arg Trp 
                245                 250                 255     


Ser Lys Lys Gly Gly Thr Leu Pro Asn Gln Arg Phe Ser Thr Thr Gln 
            260                 265                 270         


His Gly Lys Leu Thr Leu Asn Asn Ile Gln Pro Gly Asp Glu Gly Glu 
        275                 280                 285             


Tyr Val Cys Ser Val Ser Pro Thr Leu Ser Val Ser Ser Met Leu Ile 
    290                 295                 300                 


Val Gln Met Thr Ser Pro Ser Phe Asn Lys Leu Phe Pro Asp Gly Thr 
305                 310                 315                 320 


Ser Thr Ala Ser Pro Leu Pro Gln Ala Lys Pro Ser Ile Thr Met Leu 
                325                 330                 335     


Pro Lys Asp Val Ile Val Arg Glu Gly Ala Thr Ala Lys Phe Ser Cys 
            340                 345                 350         


Lys Ala Thr Gly Asn Pro Leu Pro Thr Val Phe Trp Asp Gln Lys Ser 
        355                 360                 365             


Thr Arg Gln Thr Met Phe Pro His Gln Asn Asn Gly Arg Phe Glu Val 
    370                 375                 380                 


Lys Thr Xaa Gly Asp Leu Ile Ile Lys Asn Val Gln Lys Gln Asp Lys 
385                 390                 395                 400 


Gly Glu Tyr Val Cys Ser Ala Ile Ser Gln Ala Gly Val Glu Thr Ala 
                405                 410                 415     


Ser Ala Met Leu Val Val Val Gly Ile Leu Asp Thr Lys Pro Thr Leu 
            420                 425                 430         


Lys Thr Lys Pro Leu Asn Gln Thr Val Asn Lys Phe Glu Asp Ala Ile 
        435                 440                 445             


Phe Ser Cys Thr Phe Asp Gly Val Pro Val Pro Ser Ile Glu Trp Ser 
    450                 455                 460                 


Lys Gly Leu Val Leu Ser Asn Ser Ala Lys Tyr Ile Ile Lys Thr Val 
465                 470                 475                 480 


Gly Ser Thr Ser Gln Leu Lys Val Ile Ser Ser Thr Gln Asn Asp Ala 
                485                 490                 495     


Gly Gln Tyr Glu Cys Thr Ala Thr Asn Thr Leu Gly Thr Val Lys Gly 
            500                 505                 510         


Val Val Gln Leu Thr Val Val Asp Pro Thr Thr Thr Leu Leu Pro Val 
        515                 520                 525             


Val Leu Thr Thr Lys Pro Ala Val Pro Pro Leu Lys Lys Leu Gln Pro 
    530                 535                 540                 


Pro Ser His Leu Ile Ala Arg Pro Leu Lys Ser His Asp Ser Val Glu 
545                 550                 555                 560 


Leu Val Trp Thr Ser Thr Lys Ala Ser Leu Ser Gln Pro Ile Met Tyr 
                565                 570                 575     


Thr Val Glu Tyr Arg Lys Val Gly His Lys Met Trp Lys Val Ala Met 
            580                 585                 590         


Leu Leu Thr Thr Val Asp Arg Cys Lys Val Thr Asn Leu Gln Pro Leu 
        595                 600                 605             


Thr Met Tyr Glu Phe Ser Val Arg Ala Lys Ala Gly Gln Glu Gln Ser 
    610                 615                 620                 


Lys Arg Thr Thr Thr Arg Phe Lys Thr Arg Arg Lys Thr Ala Thr Ser 
625                 630                 635                 640 


Val Val Pro Val Ile Pro Arg Lys Pro Arg Pro Thr Thr Phe Gly Pro 
                645                 650                 655     


Ala Lys Asn Ala Lys Val Ile Val Lys Ala Lys Pro Val Lys Trp Asp 
            660                 665                 670         


Lys Leu Asn Ile Thr Trp Lys Phe Asp Arg Lys Ile Lys Lys Leu Ser 
        675                 680                 685             


Ala Gly Phe Asn Val Phe Trp Arg Lys Glu Glu Ser Ala Asp Asp Phe 
    690                 695                 700                 


Lys Gln Met Ala Val Ile Gly Asp Gly Val Gln Glu His Met Leu Asn 
705                 710                 715                 720 


Gly Leu Ser Ala Asn Thr Ser Tyr Val Ile Gln Val Glu Val Tyr Phe 
                725                 730                 735     


Ser Lys His Thr Leu Pro Lys Ser Glu Glu Val Val Gly Val Thr Gly 
            740                 745                 750         


Val Arg Asp Lys Gly Leu Ile Val Ile Leu Asp Glu Gly Lys Lys Asp 
        755                 760                 765             


Gly Ser Glu Gly Asp Val Gln Ile Ile Gln Ala Asp Thr Lys Ser Gly 
    770                 775                 780                 


Gly Thr Trp Ser Arg Val Xaa Glu Phe Val Arg Lys Pro Trp Phe Ile 
785                 790                 795                 800 


Ala Ile Met Gly Gly Ile Leu Trp Ile Gly Leu Phe Val Ile Val Leu 
                805                 810                 815     


Phe Leu Tyr Arg Arg Arg Arg Arg Asn Arg Arg Asn Leu Lys Gln Arg 
            820                 825                 830         


Lys Leu Lys Leu Gln Ile Ala Glu Ile Gln Arg Ala Pro Thr Ser Pro 
        835                 840                 845             


Gln Gly His Lys Thr Leu Trp Met Asp Asp Val Asn Thr Thr Asp Thr 
    850                 855                 860                 


Pro Pro Gln Gln Leu Ala Asn Asn Arg Ile Ser Asp Thr Ser Ser Thr 
865                 870                 875                 880 


Glu Cys Leu Asn Arg Ser Val Thr Ser Cys Cys Ala Arg Arg Gly Ile 
                885                 890                 895     


Asn Ser Asn Thr Ala Asp Phe Pro Asn Lys Ile Thr Ile Asn Ser Leu 
            900                 905                 910         


Thr Gly Ser Arg Leu Gly Glu Pro Asn Gln Phe Asp Ala Ser Thr Glu 
        915                 920                 925             


Ser Lys Leu Ser Ser Glu Gly Lys Thr Asn Asn Val His His Ser Ile 
    930                 935                 940                 


Asn Asn Tyr Arg Glu His Leu Asn Lys Ser Thr Lys Phe Asp Glu Val 
945                 950                 955                 960 


Gly Glu Arg Gly Ser Leu Gly Ser Arg Ser Gly Ser Glu Ala Thr Leu 
                965                 970                 975     


Pro Arg Ala Met Pro Gln Gln Thr Ser Phe Leu Thr Pro Thr Gln Gln 
            980                 985                 990         


Phe Ile Asn Arg Lys Lys Ala Asn  Thr Arg Ser Asp Ser  Pro Ala Ser 
        995                 1000                 1005             


Gln His  Lys Asp Pro Asn Lys  Thr Pro Asp Asp Ser  Ser Ile Ser 
    1010                 1015                 1020             


Glu Lys  Ser Lys Pro Lys Leu  Lys Ile Gln Ser Phe  Glu Met Ala 
    1025                 1030                 1035             


Ser Asn  Gly Ser Ile Pro Gly  Thr Thr Thr Phe His  Ala Asp Pro 
    1040                 1045                 1050             


Pro Pro  Thr Tyr Glu Ala Val  Leu Lys Glu Thr Glu  Leu Glu Lys 
    1055                 1060                 1065             


Gln Leu  Glu Asp Gly Glu Glu  Lys Ser Lys Ser Arg  Glu Glu Leu 
    1070                 1075                 1080             


Ala Glu  Lys Leu Lys Gly Thr  Pro Phe Asn Asp Lys  Pro Thr Pro 
    1085                 1090                 1095             


Arg Ala  Pro Ser Pro Pro Leu  Ser Glu Arg Ser Cys  Arg Thr Thr 
    1100                 1105                 1110             


Ser Ser  Cys Gly Ser Arg Lys  Arg Lys Val Leu Lys  Pro Pro Pro 
    1115                 1120                 1125             


Arg Leu  Ala Ile Leu Asn Trp  Ala Asp Leu Leu Pro  Pro Pro Pro 
    1130                 1135                 1140             


Ser His  Pro Pro Pro Ser Ser  Leu Gly Ser Pro Pro  Pro Ser Pro 
    1145                 1150                 1155             


Pro Phe  Ser Leu Arg Ser Gly  Met Thr Gly Met Ser  Gly Met Thr 
    1160                 1165                 1170             


Gly Met  Ser Gly Leu Thr Gly  Met Ser Gly Met Thr  Gly Leu Thr 
    1175                 1180                 1185             


Gly Met  Thr Gly Met Thr Gly  Arg Thr Gly Lys Ser  Ser Gly Asn 
    1190                 1195                 1200             


Gly Leu  Val Asp Asn Glu Ile  Pro Glu Arg Pro Arg  Lys Lys Pro 
    1205                 1210                 1215             


Pro Ser  Ser Ala Val Ser Asp  Ser Ala Val Ser Ala  Ala Glu Pro 
    1220                 1225                 1230             


Lys Val  Pro Gly Ser Thr Lys  Ser Gly Lys Ser Gly  His Lys His 
    1235                 1240                 1245             


Lys Lys  Pro Lys Pro Lys Ala  Leu Pro Ile Asp Leu  Glu Gly Ile 
    1250                 1255                 1260             


Thr Ser  Asp Ile Ile Met Gln  Trp Ala Asp Ser Val  Thr Asn Thr 
    1265                 1270                 1275             


Ser Gly  Ser Asp Asp Asp Ser  Ser Cys Ser Ser Pro  Ser Arg Val 
    1280                 1285                 1290             


Ser Ser  Thr Gly Ser Phe Phe  Thr Asp Ala Asp Phe  Ala Asn Ala 
    1295                 1300                 1305             


Val Arg  Ala Ala Ala Glu Cys  Gly Gly Phe Asn Met  Glu Thr Tyr 
    1310                 1315                 1320             


Gly Leu  Met Asp Ser Leu Gly  Tyr Pro Pro Pro Tyr  Ser Gly Ser 
    1325                 1330                 1335             


Trp Lys  Lys Gly Asn Ser Thr  Pro Ser Gly Ser Asp  Pro Ser Gly 
    1340                 1345                 1350             


Pro Ile  Thr Ser Thr Pro Arg  Asn Pro Gln Asn Lys  Thr Lys Trp 
    1355                 1360                 1365             


Glu Thr  Gly Ser Glu Gly Asp  Leu Asp Phe Thr Pro  Pro Ile Thr 
    1370                 1375                 1380             


Val Arg  Pro Arg Phe Thr Arg  Lys Val Gln Pro Asn  Glu Asn Gly 
    1385                 1390                 1395             


Thr Pro  Pro Pro Val Ala Pro  Ser Lys Met Ala Ala  Asp Met Gly 
    1400                 1405                 1410             


Ile Arg  Lys Val Ala Arg Ser  Pro Val Pro Leu Val  Pro Ser Gln 
    1415                 1420                 1425             


Pro Arg  Arg Pro Ile Pro Arg  Ala Ala Arg Met Asn  Ser Asn Ser 
    1430                 1435                 1440             


Pro Val  Pro Gly Pro Gly Gln  Ile Ile Val Gln Pro  Leu Lys Lys 
    1445                 1450                 1455             


Thr Ser  Ala Leu Asn Ala Pro  Glu Ser Ala Ser Lys  Ile Pro Val 
    1460                 1465                 1470             


Thr Lys  Lys Phe Ala Val Val  Lys Lys Ile Pro Gln  Ser Lys Asp 
    1475                 1480                 1485             


Thr Glu  Pro Tyr Asn Ser Ala  Thr Leu Ser Ser Ser  Gly Lys Ser 
    1490                 1495                 1500             


Ser Thr  Ser Thr Ala Ser Thr  Val Lys Thr Ser Thr  Met Gly Asp 
    1505                 1510                 1515             


Ser Asp  Ala Glu Ser Ala Ala  
    1520                 1525 


<210>  16
<211>  1651
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Lys Trp Lys His Val Pro Phe Leu Val Met Ile Ser Leu Leu Ser 
1               5                   10                  15      


Leu Ser Pro Asn His Leu Phe Leu Ala Gln Leu Ile Pro Asp Pro Glu 
            20                  25                  30          


Asp Val Glu Arg Gly Asn Asp His Gly Thr Pro Ile Pro Thr Ser Asp 
        35                  40                  45              


Asn Asp Asp Asn Ser Leu Gly Tyr Thr Gly Ser Arg Leu Arg Gln Glu 
    50                  55                  60                  


Asp Phe Pro Pro Arg Ile Val Glu His Pro Ser Asp Leu Ile Val Ser 
65                  70                  75                  80  


Lys Gly Glu Pro Ala Thr Leu Asn Cys Lys Ala Glu Gly Arg Pro Thr 
                85                  90                  95      


Pro Thr Ile Glu Trp Tyr Lys Gly Gly Glu Arg Val Glu Thr Asp Lys 
            100                 105                 110         


Asp Asp Pro Arg Ser His Arg Met Leu Leu Pro Ser Gly Ser Leu Phe 
        115                 120                 125             


Phe Leu Arg Ile Val His Gly Arg Lys Ser Arg Pro Asp Glu Gly Val 
    130                 135                 140                 


Tyr Val Cys Val Ala Arg Asn Tyr Leu Gly Glu Ala Val Ser His Asn 
145                 150                 155                 160 


Ala Ser Leu Glu Val Ala Ile Leu Arg Asp Asp Phe Arg Gln Asn Pro 
                165                 170                 175     


Ser Asp Val Met Val Ala Val Gly Glu Pro Ala Val Met Glu Cys Gln 
            180                 185                 190         


Pro Pro Arg Gly His Pro Glu Pro Thr Ile Ser Trp Lys Lys Asp Gly 
        195                 200                 205             


Ser Pro Leu Asp Asp Lys Asp Glu Arg Ile Thr Ile Arg Gly Gly Lys 
    210                 215                 220                 


Leu Met Ile Thr Tyr Thr Arg Lys Ser Asp Ala Gly Lys Tyr Val Cys 
225                 230                 235                 240 


Val Gly Thr Asn Met Val Gly Glu Arg Glu Ser Glu Val Ala Glu Leu 
                245                 250                 255     


Thr Val Leu Glu Arg Pro Ser Phe Val Lys Arg Pro Ser Asn Leu Ala 
            260                 265                 270         


Val Thr Val Asp Asp Ser Ala Glu Phe Lys Cys Glu Ala Arg Gly Asp 
        275                 280                 285             


Pro Val Pro Thr Val Arg Trp Arg Lys Asp Asp Gly Glu Leu Pro Lys 
    290                 295                 300                 


Ser Arg Tyr Glu Ile Arg Asp Asp His Thr Leu Lys Ile Arg Lys Val 
305                 310                 315                 320 


Thr Ala Gly Asp Met Gly Ser Tyr Thr Cys Val Ala Glu Asn Met Val 
                325                 330                 335     


Gly Lys Ala Glu Ala Ser Ala Thr Leu Thr Val Gln Glu Pro Pro His 
            340                 345                 350         


Phe Val Val Lys Pro Arg Asp Gln Val Val Ala Leu Gly Arg Thr Val 
        355                 360                 365             


Thr Phe Gln Cys Glu Ala Thr Gly Asn Pro Gln Pro Ala Ile Phe Trp 
    370                 375                 380                 


Arg Arg Glu Gly Ser Gln Asn Leu Leu Phe Ser Tyr Gln Pro Pro Gln 
385                 390                 395                 400 


Ser Ser Ser Arg Phe Ser Val Ser Gln Thr Gly Asp Leu Thr Ile Thr 
                405                 410                 415     


Asn Val Gln Arg Ser Asp Val Gly Tyr Tyr Ile Cys Gln Thr Leu Asn 
            420                 425                 430         


Val Ala Gly Ser Ile Ile Thr Lys Ala Tyr Leu Glu Val Thr Asp Val 
        435                 440                 445             


Ile Ala Asp Arg Pro Pro Pro Val Ile Arg Gln Gly Pro Val Asn Gln 
    450                 455                 460                 


Thr Val Ala Val Asp Gly Thr Phe Val Leu Ser Cys Val Ala Thr Gly 
465                 470                 475                 480 


Ser Pro Val Pro Thr Ile Leu Trp Arg Lys Asp Gly Val Leu Val Ser 
                485                 490                 495     


Thr Gln Asp Ser Arg Ile Lys Gln Leu Glu Asn Gly Val Leu Gln Ile 
            500                 505                 510         


Arg Tyr Ala Lys Leu Gly Asp Thr Gly Arg Tyr Thr Cys Ile Ala Ser 
        515                 520                 525             


Thr Pro Ser Gly Glu Ala Thr Trp Ser Ala Tyr Ile Glu Val Gln Glu 
    530                 535                 540                 


Phe Gly Val Pro Val Gln Pro Pro Arg Pro Thr Asp Pro Asn Leu Ile 
545                 550                 555                 560 


Pro Ser Ala Pro Ser Lys Pro Glu Val Thr Asp Val Ser Arg Asn Thr 
                565                 570                 575     


Val Thr Leu Ser Trp Gln Pro Asn Leu Asn Ser Gly Ala Thr Pro Thr 
            580                 585                 590         


Ser Tyr Ile Ile Glu Ala Phe Ser His Ala Ser Gly Ser Ser Trp Gln 
        595                 600                 605             


Thr Val Ala Glu Asn Val Lys Thr Glu Thr Ser Ala Ile Lys Gly Leu 
    610                 615                 620                 


Lys Pro Asn Ala Ile Tyr Leu Phe Leu Val Arg Ala Ala Asn Ala Tyr 
625                 630                 635                 640 


Gly Ile Ser Asp Pro Ser Gln Ile Ser Asp Pro Val Lys Thr Gln Asp 
                645                 650                 655     


Val Leu Pro Thr Ser Gln Gly Val Asp His Lys Gln Val Gln Arg Glu 
            660                 665                 670         


Leu Gly Asn Ala Val Leu His Leu His Asn Pro Thr Val Leu Ser Ser 
        675                 680                 685             


Ser Ser Ile Glu Val His Trp Thr Val Asp Gln Gln Ser Gln Tyr Ile 
    690                 695                 700                 


Gln Gly Tyr Lys Ile Leu Tyr Arg Pro Ser Gly Ala Asn His Gly Glu 
705                 710                 715                 720 


Ser Asp Trp Leu Val Phe Glu Val Arg Thr Pro Ala Lys Asn Ser Val 
                725                 730                 735     


Val Ile Pro Asp Leu Arg Lys Gly Val Asn Tyr Glu Ile Lys Ala Arg 
            740                 745                 750         


Pro Phe Phe Asn Glu Phe Gln Gly Ala Asp Ser Glu Ile Lys Phe Ala 
        755                 760                 765             


Lys Thr Leu Glu Glu Ala Pro Ser Ala Pro Pro Gln Gly Val Thr Val 
    770                 775                 780                 


Ser Lys Asn Asp Gly Asn Gly Thr Ala Ile Leu Val Ser Trp Gln Pro 
785                 790                 795                 800 


Pro Pro Glu Asp Thr Gln Asn Gly Met Val Gln Glu Tyr Lys Val Trp 
                805                 810                 815     


Cys Leu Gly Asn Glu Thr Arg Tyr His Ile Asn Lys Thr Val Asp Gly 
            820                 825                 830         


Ser Thr Phe Ser Val Val Ile Pro Phe Leu Val Pro Gly Ile Arg Tyr 
        835                 840                 845             


Ser Val Glu Val Ala Ala Ser Thr Gly Ala Gly Ser Gly Val Lys Ser 
    850                 855                 860                 


Glu Pro Gln Phe Ile Gln Leu Asp Ala His Gly Asn Pro Val Ser Pro 
865                 870                 875                 880 


Glu Asp Gln Val Ser Leu Ala Gln Gln Ile Ser Asp Val Val Lys Gln 
                885                 890                 895     


Pro Ala Phe Ile Ala Gly Ile Gly Ala Ala Cys Trp Ile Ile Leu Met 
            900                 905                 910         


Val Phe Ser Ile Trp Leu Tyr Arg His Arg Lys Lys Arg Asn Gly Leu 
        915                 920                 925             


Thr Ser Thr Tyr Ala Gly Ile Arg Lys Val Pro Ser Phe Thr Phe Thr 
    930                 935                 940                 


Pro Thr Val Thr Tyr Gln Arg Gly Gly Glu Ala Val Ser Ser Gly Gly 
945                 950                 955                 960 


Arg Pro Gly Leu Leu Asn Ile Ser Glu Pro Ala Ala Gln Pro Trp Leu 
                965                 970                 975     


Ala Asp Thr Trp Pro Asn Thr Gly Asn Asn His Asn Asp Cys Ser Ile 
            980                 985                 990         


Ser Cys Cys Thr Ala Gly Asn Gly  Asn Ser Asp Ser Asn  Leu Thr Thr 
        995                 1000                 1005             


Tyr Ser  Arg Pro Ala Asp Cys  Ile Ala Asn Tyr Asn  Asn Gln Leu 
    1010                 1015                 1020             


Asp Asn  Lys Gln Thr Asn Leu  Met Leu Pro Glu Ser  Thr Val Tyr 
    1025                 1030                 1035             


Gly Asp  Val Asp Leu Ser Asn  Lys Ile Asn Glu Met  Lys Thr Phe 
    1040                 1045                 1050             


Asn Ser  Pro Asn Leu Lys Asp  Gly Arg Phe Val Asn  Pro Ser Gly 
    1055                 1060                 1065             


Gln Pro  Thr Pro Tyr Ala Thr  Thr Gln Leu Ile Gln  Ser Asn Leu 
    1070                 1075                 1080             


Ser Asn  Asn Met Asn Asn Gly  Ser Gly Asp Ser Gly  Glu Lys His 
    1085                 1090                 1095             


Trp Lys  Pro Leu Gly Gln Gln  Lys Gln Glu Val Ala  Pro Val Gln 
    1100                 1105                 1110             


Tyr Asn  Ile Val Glu Gln Asn  Lys Leu Asn Lys Asp  Tyr Arg Ala 
    1115                 1120                 1125             


Asn Asp  Thr Val Pro Pro Thr  Ile Pro Tyr Asn Gln  Ser Tyr Asp 
    1130                 1135                 1140             


Gln Asn  Thr Gly Gly Ser Tyr  Asn Ser Ser Asp Arg  Gly Ser Ser 
    1145                 1150                 1155             


Thr Ser  Gly Ser Gln Gly His  Lys Lys Gly Ala Arg  Thr Pro Lys 
    1160                 1165                 1170             


Val Pro  Lys Gln Gly Gly Met  Asn Trp Ala Asp Leu  Leu Pro Pro 
    1175                 1180                 1185             


Pro Pro  Ala His Pro Pro Pro  His Ser Asn Ser Glu  Glu Tyr Asn 
    1190                 1195                 1200             


Ile Ser  Val Asp Glu Ser Tyr  Asp Gln Glu Met Pro  Cys Pro Val 
    1205                 1210                 1215             


Pro Pro  Ala Arg Met Tyr Leu  Gln Gln Asp Glu Leu  Glu Glu Glu 
    1220                 1225                 1230             


Glu Asp  Glu Arg Gly Pro Thr  Pro Pro Val Arg Gly  Ala Ala Ser 
    1235                 1240                 1245             


Ser Pro  Ala Ala Val Ser Tyr  Ser His Gln Ser Thr  Ala Thr Leu 
    1250                 1255                 1260             


Thr Pro  Ser Pro Gln Glu Glu  Leu Gln Pro Met Leu  Gln Asp Cys 
    1265                 1270                 1275             


Pro Glu  Glu Thr Gly His Met  Gln His Gln Pro Asp  Arg Arg Arg 
    1280                 1285                 1290             


Gln Pro  Val Ser Pro Pro Pro  Pro Pro Arg Pro Ile  Ser Pro Pro 
    1295                 1300                 1305             


His Thr  Tyr Gly Tyr Ile Ser  Gly Pro Leu Val Ser  Asp Met Asp 
    1310                 1315                 1320             


Thr Asp  Ala Pro Glu Glu Glu  Glu Asp Glu Ala Asp  Met Glu Val 
    1325                 1330                 1335             


Ala Lys  Met Gln Thr Arg Arg  Leu Leu Leu Arg Gly  Leu Glu Gln 
    1340                 1345                 1350             


Thr Pro  Ala Ser Ser Val Gly  Asp Leu Glu Ser Ser  Val Thr Gly 
    1355                 1360                 1365             


Ser Met  Ile Asn Gly Trp Gly  Ser Ala Ser Glu Glu  Asp Asn Ile 
    1370                 1375                 1380             


Ser Ser  Gly Arg Ser Ser Val  Ser Ser Ser Asp Gly  Ser Phe Phe 
    1385                 1390                 1395             


Thr Asp  Ala Asp Phe Ala Gln  Ala Val Ala Ala Ala  Ala Glu Tyr 
    1400                 1405                 1410             


Ala Gly  Leu Lys Val Ala Arg  Arg Gln Met Gln Asp  Ala Ala Gly 
    1415                 1420                 1425             


Arg Arg  His Phe His Ala Ser  Gln Cys Pro Arg Pro  Thr Ser Pro 
    1430                 1435                 1440             


Val Ser  Thr Asp Ser Asn Met  Ser Ala Ala Val Met  Gln Lys Thr 
    1445                 1450                 1455             


Arg Pro  Ala Lys Lys Leu Lys  His Gln Pro Gly His  Leu Arg Arg 
    1460                 1465                 1470             


Glu Thr  Tyr Thr Asp Asp Leu  Pro Pro Pro Pro Val  Pro Pro Pro 
    1475                 1480                 1485             


Ala Ile  Lys Ser Pro Thr Ala  Gln Ser Lys Thr Gln  Leu Glu Val 
    1490                 1495                 1500             


Arg Pro  Val Val Val Pro Lys  Leu Pro Ser Met Asp  Ala Arg Thr 
    1505                 1510                 1515             


Asp Arg  Ser Ser Asp Arg Lys  Gly Ser Ser Tyr Lys  Gly Arg Glu 
    1520                 1525                 1530             


Val Leu  Asp Gly Arg Gln Val  Val Asp Met Arg Thr  Asn Pro Gly 
    1535                 1540                 1545             


Asp Pro  Arg Glu Ala Gln Glu  Gln Gln Asn Asp Gly  Lys Gly Arg 
    1550                 1555                 1560             


Gly Asn  Lys Ala Ala Lys Arg  Asp Leu Pro Pro Ala  Lys Thr His 
    1565                 1570                 1575             


Leu Ile  Gln Glu Asp Ile Leu  Pro Tyr Cys Arg Pro  Thr Phe Pro 
    1580                 1585                 1590             


Thr Ser  Asn Asn Pro Arg Asp  Pro Ser Ser Ser Ser  Ser Met Ser 
    1595                 1600                 1605             


Ser Arg  Gly Ser Gly Ser Arg  Gln Arg Glu Gln Ala  Asn Val Gly 
    1610                 1615                 1620             


Arg Arg  Asn Ile Ala Glu Met  Gln Val Leu Gly Gly  Tyr Glu Arg 
    1625                 1630                 1635             


Gly Glu  Asp Asn Asn Glu Glu  Leu Glu Glu Thr Glu  Ser 
    1640                 1645                 1650     


<210>  17
<211>  1386
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Leu Arg Tyr Leu Leu Lys Thr Leu Leu Gln Met Asn Leu Phe Ala 
1               5                   10                  15      


Asp Ser Leu Ala Gly Asp Ile Ser Asn Ser Ser Glu Leu Leu Leu Gly 
            20                  25                  30          


Phe Asn Ser Ser Leu Ala Ala Leu Asn His Thr Leu Leu Pro Pro Gly 
        35                  40                  45              


Asp Pro Ser Leu Asn Gly Ser Arg Val Gly Pro Glu Asp Ala Met Pro 
    50                  55                  60                  


Arg Ile Val Glu Gln Pro Pro Asp Leu Leu Val Ser Arg Gly Glu Pro 
65                  70                  75                  80  


Ala Thr Leu Pro Cys Arg Ala Glu Gly Arg Pro Arg Pro Asn Ile Glu 
                85                  90                  95      


Trp Tyr Lys Asn Gly Ala Arg Val Ala Thr Val Arg Glu Asp Pro Arg 
            100                 105                 110         


Ala His Arg Leu Leu Leu Pro Ser Gly Ala Leu Phe Phe Pro Arg Ile 
        115                 120                 125             


Val His Gly Arg Arg Ala Arg Pro Asp Glu Gly Val Tyr Thr Cys Val 
    130                 135                 140                 


Ala Arg Asn Tyr Leu Gly Ala Ala Ala Ser Arg Asn Ala Ser Leu Glu 
145                 150                 155                 160 


Val Ala Val Leu Arg Asp Asp Phe Arg Gln Ser Pro Gly Asn Val Val 
                165                 170                 175     


Val Ala Val Gly Glu Pro Ala Val Leu Glu Cys Val Pro Pro Arg Gly 
            180                 185                 190         


His Pro Glu Pro Ser Val Ser Trp Arg Lys Asp Gly Ala Arg Leu Lys 
        195                 200                 205             


Glu Glu Glu Gly Arg Ile Thr Ile Arg Gly Gly Lys Leu Met Met Ser 
    210                 215                 220                 


His Thr Leu Lys Ser Asp Ala Gly Met Tyr Val Cys Val Ala Ser Asn 
225                 230                 235                 240 


Met Ala Gly Glu Arg Glu Ser Ala Ala Ala Glu Val Met Val Leu Glu 
                245                 250                 255     


Arg Pro Ser Phe Leu Arg Arg Pro Val Asn Gln Val Val Leu Ala Asp 
            260                 265                 270         


Ala Pro Val Thr Phe Leu Cys Glu Val Lys Gly Asp Pro Pro Pro Arg 
        275                 280                 285             


Leu Arg Trp Arg Lys Glu Asp Gly Glu Leu Pro Thr Gly Arg Tyr Glu 
    290                 295                 300                 


Ile Arg Ser Asp His Ser Leu Trp Ile Gly His Val Ser Ala Glu Asp 
305                 310                 315                 320 


Glu Gly Thr Tyr Thr Cys Val Ala Glu Asn Ser Val Gly Arg Ala Glu 
                325                 330                 335     


Ala Ser Gly Ser Leu Ser Val His Val Pro Pro Gln Leu Val Thr Gln 
            340                 345                 350         


Pro Gln Asp Gln Met Ala Ala Pro Gly Glu Ser Val Ala Phe Gln Cys 
        355                 360                 365             


Glu Thr Lys Gly Asn Pro Pro Pro Ala Ile Phe Trp Gln Lys Glu Gly 
    370                 375                 380                 


Ser Gln Val Leu Leu Phe Pro Ser Gln Ser Leu Gln Pro Thr Gly Arg 
385                 390                 395                 400 


Phe Ser Val Ser Pro Arg Gly Gln Leu Asn Ile Thr Ala Val Gln Arg 
                405                 410                 415     


Gly Asp Ala Gly Tyr Tyr Val Cys Gln Ala Val Ser Val Ala Gly Ser 
            420                 425                 430         


Ile Leu Ala Lys Ala Leu Leu Glu Ile Lys Gly Ala Ser Leu Asp Gly 
        435                 440                 445             


Leu Pro Pro Val Ile Leu Gln Gly Pro Ala Asn Gln Thr Leu Val Leu 
    450                 455                 460                 


Gly Ser Ser Val Trp Leu Pro Cys Arg Val Thr Gly Asn Pro Gln Pro 
465                 470                 475                 480 


Ser Val Arg Trp Lys Lys Asp Gly Gln Trp Leu Gln Gly Asp Asp Leu 
                485                 490                 495     


Gln Phe Lys Thr Met Ala Asn Gly Thr Leu Tyr Ile Ala Asn Val Gln 
            500                 505                 510         


Glu Met Asp Met Gly Phe Tyr Ser Cys Val Ala Lys Ser Ser Thr Gly 
        515                 520                 525             


Glu Ala Thr Trp Ser Gly Trp Leu Lys Met Arg Glu Asp Trp Gly Val 
    530                 535                 540                 


Ser Pro Asp Pro Pro Thr Glu Pro Ser Ser Pro Pro Gly Ala Pro Ser 
545                 550                 555                 560 


Gln Pro Val Val Thr Glu Ile Thr Lys Asn Ser Ile Thr Leu Thr Trp 
                565                 570                 575     


Lys Pro Asn Pro Gln Thr Gly Ala Ala Val Thr Ser Tyr Val Ile Glu 
            580                 585                 590         


Ala Phe Ser Pro Ala Ala Gly Asn Thr Trp Arg Thr Val Ala Asp Gly 
        595                 600                 605             


Val Gln Leu Glu Thr His Thr Val Ser Gly Leu Gln Pro Asn Thr Ile 
    610                 615                 620                 


Tyr Leu Phe Leu Val Arg Ala Val Gly Ala Trp Gly Leu Ser Glu Pro 
625                 630                 635                 640 


Ser Pro Val Ser Glu Pro Val Arg Thr Gln Asp Ser Ser Pro Ser Arg 
                645                 650                 655     


Pro Val Glu Asp Pro Trp Arg Gly Gln Gln Gly Leu Ala Glu Val Ala 
            660                 665                 670         


Val Arg Leu Gln Glu Pro Ile Val Leu Gly Pro Arg Thr Leu Gln Val 
        675                 680                 685             


Ser Trp Thr Val Asp Gly Pro Val Gln Leu Val Gln Gly Phe Arg Val 
    690                 695                 700                 


Ser Trp Arg Val Ala Gly Pro Glu Gly Gly Ser Trp Thr Met Leu Asp 
705                 710                 715                 720 


Leu Gln Ser Pro Ser Gln Gln Ser Thr Val Leu Arg Gly Leu Pro Pro 
                725                 730                 735     


Gly Thr Gln Ile Gln Ile Lys Val Gln Ala Gln Gly Gln Glu Gly Leu 
            740                 745                 750         


Gly Ala Glu Ser Leu Ser Val Thr Arg Ser Ile Pro Glu Glu Ala Pro 
        755                 760                 765             


Ser Gly Pro Pro Gln Gly Val Ala Val Ala Leu Gly Gly Asp Gly Asn 
    770                 775                 780                 


Ser Ser Ile Thr Val Ser Trp Glu Pro Pro Leu Pro Ser Gln Gln Asn 
785                 790                 795                 800 


Gly Val Ile Thr Glu Tyr Gln Ile Trp Cys Leu Gly Asn Glu Ser Arg 
                805                 810                 815     


Phe His Leu Asn Arg Ser Ala Ala Gly Trp Ala Arg Ser Ala Met Leu 
            820                 825                 830         


Arg Gly Leu Val Pro Gly Leu Leu Tyr Arg Thr Leu Val Ala Ala Ala 
        835                 840                 845             


Thr Ser Ala Gly Val Gly Val Pro Ser Ala Pro Val Leu Val Gln Leu 
    850                 855                 860                 


Pro Ser Pro Pro Asp Leu Glu Pro Gly Leu Glu Val Gly Ala Gly Leu 
865                 870                 875                 880 


Ala Val Arg Leu Ala Arg Val Leu Arg Glu Pro Ala Phe Leu Ala Gly 
                885                 890                 895     


Ser Gly Ala Ala Cys Gly Ala Leu Leu Leu Gly Leu Cys Ala Ala Leu 
            900                 905                 910         


Tyr Trp Arg Arg Lys Gln Arg Lys Glu Leu Ser His Tyr Thr Ala Ser 
        915                 920                 925             


Phe Ala Tyr Thr Pro Ala Val Ser Phe Pro His Ser Glu Gly Leu Ser 
    930                 935                 940                 


Gly Ala Ser Ser Arg Pro Pro Met Gly Leu Gly Pro Ala Pro Tyr Ser 
945                 950                 955                 960 


Trp Leu Ala Asp Ser Trp Pro His Pro Ser Arg Ser Pro Ser Ala Gln 
                965                 970                 975     


Glu Pro Arg Gly Ser Cys Cys Pro Ser Asn Pro Asp Pro Asp Asp Arg 
            980                 985                 990         


Tyr Tyr Asn Glu Ala Gly Ile Ser  Leu Tyr Leu Ala Gln  Thr Ala Arg 
        995                 1000                 1005             


Gly Thr  Ala Ala Pro Gly Glu  Gly Pro Val Tyr Ser  Thr Ile Asp 
    1010                 1015                 1020             


Pro Ala  Gly Glu Glu Leu Gln  Thr Phe His Gly Gly  Phe Pro Gln 
    1025                 1030                 1035             


His Pro  Ser Gly Asp Leu Gly  Pro Trp Ser Gln Tyr  Ala Pro Pro 
    1040                 1045                 1050             


Glu Trp  Ser Gln Gly Asp Ser  Gly Ala Lys Gly Gly  Lys Val Lys 
    1055                 1060                 1065             


Leu Leu  Gly Lys Pro Val Gln  Met Pro Ser Leu Asn  Trp Pro Glu 
    1070                 1075                 1080             


Ala Leu  Pro Pro Pro Pro Pro  Ser Cys Glu Leu Ser  Cys Leu Glu 
    1085                 1090                 1095             


Gly Pro  Glu Glu Glu Leu Glu  Gly Ser Ser Glu Pro  Glu Glu Trp 
    1100                 1105                 1110             


Cys Pro  Pro Met Pro Glu Arg  Ser His Leu Thr Glu  Pro Ser Ser 
    1115                 1120                 1125             


Ser Gly  Gly Cys Leu Val Thr  Pro Ser Arg Arg Glu  Thr Pro Ser 
    1130                 1135                 1140             


Pro Thr  Pro Ser Tyr Gly Gln  Gln Ser Thr Ala Thr  Leu Thr Pro 
    1145                 1150                 1155             


Ser Pro  Pro Asp Pro Pro Gln  Pro Pro Thr Asp Met  Pro His Leu 
    1160                 1165                 1170             


His Gln  Met Pro Arg Arg Val  Pro Leu Gly Pro Ser  Ser Pro Leu 
    1175                 1180                 1185             


Ser Val  Ser Gln Pro Met Leu  Gly Ile Arg Glu Ala  Arg Pro Ala 
    1190                 1195                 1200             


Gly Leu  Gly Ala Gly Pro Ala  Ala Ser Pro His Leu  Ser Pro Ser 
    1205                 1210                 1215             


Pro Ala  Pro Ser Thr Ala Ser  Ser Ala Pro Gly Arg  Thr Trp Gln 
    1220                 1225                 1230             


Gly Asn  Gly Glu Met Thr Pro  Pro Leu Gln Gly Pro  Arg Ala Arg 
    1235                 1240                 1245             


Phe Arg  Lys Lys Pro Lys Ala  Leu Pro Tyr Arg Arg  Glu Asn Ser 
    1250                 1255                 1260             


Pro Gly  Asp Leu Pro Pro Pro  Pro Leu Pro Pro Pro  Glu Glu Glu 
    1265                 1270                 1275             


Ala Ser  Trp Ala Leu Glu Leu  Arg Ala Ala Gly Ser  Met Ser Ser 
    1280                 1285                 1290             


Leu Glu  Arg Glu Arg Ser Gly  Glu Arg Lys Ala Val  Gln Ala Val 
    1295                 1300                 1305             


Pro Leu  Ala Ala Gln Arg Val  Leu His Pro Asp Glu  Glu Ala Trp 
    1310                 1315                 1320             


Leu Pro  Tyr Ser Arg Pro Ser  Phe Leu Ser Arg Gly  Gln Gly Thr 
    1325                 1330                 1335             


Ser Thr  Cys Ser Thr Ala Gly  Ser Asn Ser Ser Arg  Gly Ser Ser 
    1340                 1345                 1350             


Ser Ser  Arg Gly Ser Arg Gly  Pro Gly Arg Ser Arg  Ser Arg Ser 
    1355                 1360                 1365             


Gln Ser  Arg Ser Gln Ser Gln  Arg Pro Gly Gln Lys  Arg Arg Glu 
    1370                 1375                 1380             


Glu Pro  Arg 
    1385     


<210>  18
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Robo receptor ectodomain D3 dimerization interface  amino acid 
       sequence

<400>  18

Lys Lys Asp Asp Ala Asp Leu Pro Arg Gly Arg Tyr 
1               5                   10          


<210>  19
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Robo receptor ectodomain D3 dimerization interface amino acid 
       sequence

<400>  19

Arg Lys Asp Asp Gly Glu Leu Pro Lys Ser Arg Tyr 
1               5                   10          


<210>  20
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Robo receptor ectodomain D3 dimerization interface amino acid 
       sequence

<400>  20

Arg Lys Glu Asp Gly Glu Leu Pro Thr Gly Arg Tyr 
1               5                   10          


<210>  21
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  21

Pro Arg Asp Gln Ile 
1               5   


<210>  22
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Asn Leu Leu Phe Pro Asn Gln Pro 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  23

Ser Arg Cys Ser Val Ser Pro Thr Gly 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  24

Ala Gly Tyr Tyr Ile Cys Gln Ala Leu 
1               5                   


<210>  25
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  25

Glu Phe Arg Cys Gln Val Gln Gly Asp Pro Gln Pro 
1               5                   10          


<210>  26
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Val Gly Glu Arg Asp Ser Asp Pro Ala Glu Leu Thr Val Phe Glu 
1               5                   10                  15      


Arg Pro Thr Phe Leu Arg Arg Pro Ile Asn Gln Val Val Leu Glu Glu 
            20                  25                  30          


Glu Ala Val Glu Phe Arg Cys Gln Val Gln Gly Asp Pro Gln Pro Thr 
        35                  40                  45              


Val Arg Trp Lys Lys Asp Asp Ala Asp Leu Pro Arg Gly Arg Tyr Asp 
    50                  55                  60                  


Ile Lys Asp Asp Tyr Thr Leu Arg Ile Lys Lys Thr Met Ser Thr Asp 
65                  70                  75                  80  


Glu Gly Thr Tyr Met Cys Ile Ala Glu 
                85                  


<210>  27
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  D4 dimerization interface Amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  selected from the group consisting of Valine and Isoleucine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  selected from the group consisting of Glutamine and Arginine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  selected from the group consisting of Lysine and Arginine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  selected from the group consisting of Asparagine and Valine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  selected from the group consisting of Proline and Serine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  selected from the group consisting of Asparagine, Tyrosine and 
       Serine

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (26)..(28)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  selected from the group consisting of Alanine and Threonine

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  selected from the group consisting of Leucine and Valine

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  selected from the group consisting of Threonine, Asparagine and 
       Serine

<220>
<221>  MISC_FEATURE
<222>  (64)..(64)
<223>  selected from the group consisting of Alanine and Threonine

<400>  27

Gly Asn Pro Gln Pro Ala Xaa Phe Trp Xaa Xaa Glu Gly Ser Gln Xaa 
1               5                   10                  15      


Leu Leu Phe Xaa Xaa Gln Pro Xaa Gln Xaa Xaa Xaa Arg Xaa Ser Val 
            20                  25                  30          


Ser Xaa Xaa Gly Xaa Leu Xaa Ile Thr Xaa Xaa Gln Arg Xaa Asp Xaa 
        35                  40                  45              


Gly Tyr Tyr Xaa Cys Gln Xaa Xaa Xaa Val Ala Gly Ser Ile Leu Xaa 
    50                  55                  60                  


<210>  28
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  hRobo2 receptor ectodomain D4-D5partial sequence - 7-residuelong 
       coil

<400>  28

Asp Val Leu Thr Asp Arg Pro 
1               5           


<210>  29
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  partial amino acid sequence of the hRobo2 D3 CD loop

<400>  29

Asp Asp Ala Asp 
1               


<210>  30
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  partial amino acid sequence of the mutated form of hRobo2 D3 CD 
       loop

<400>  30

Ser Lys Ala Lys 
1               


<210>  31
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  31

Gly Asn Pro Gln Pro Ala Val Phe Trp Gln Lys Glu Gly Ser Gln Asn 
1               5                   10                  15      


Leu Leu Phe Pro Asn Gln Pro Gln Gln Pro Asn Ser Arg Cys Ser Val 
            20                  25                  30          


Ser Pro Thr Gly Asp Leu Thr Ile Thr Asn Ile Gln Arg Ser Asp Ala 
        35                  40                  45              


Gly Tyr Tyr Ile Cys Gln Ala Leu Thr Val Ala Gly Ser Ile Leu Ala 
    50                  55                  60                  


<210>  32
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  32

Gly Asn Pro Gln Pro Ala Ile Phe Trp Arg Arg Glu Gly Ser Gln Asn 
1               5                   10                  15      


Leu Leu Phe Ser Tyr Gln Pro Pro Gln Ser Ser Ser Arg Phe Ser Val 
            20                  25                  30          


Ser Gln Thr Gly Asp Leu Thr Ile Thr Asn Val Gln Arg Ser Asp Val 
        35                  40                  45              


Gly Tyr Tyr Ile Cys Gln Thr Leu Asn Val Ala Gly Ser Ile Ile Thr 
    50                  55                  60                  


<210>  33
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  33

Gly Asn Pro Pro Pro Ala Ile Phe Trp Gln Lys Glu Gly Ser Gln Val 
1               5                   10                  15      


Leu Leu Phe Pro Ser Gln Ser Leu Gln Pro Thr Gly Arg Phe Ser Val 
            20                  25                  30          


Ser Pro Arg Gly Gln Leu Asn Ile Thr Ala Val Gln Arg Gly Asp Ala 
        35                  40                  45              


Gly Tyr Tyr Val Cys Gln Ala Val Ser Val Ala Gly Ser Ile Leu Ala 
    50                  55                  60                  


<210>  34
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Robo receptor ectodomain D4 dimerization interface comprises the 
       amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  selected from the group consisting of Valine and Isoleucine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  selected from the group consisting of Glutamine and Arginine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  selected from the group consisting of Lysine and Arginine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  selected from the group consisting of Asparagine and Valine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  selected from the group consisting of Proline and Serine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  selected from the group consisting of Asparagine, Tyrosine and 
       Serine

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  selected from the group consisting of Glutamine, proline and 
       Leucine

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  selected from the group consisting of Proline and Serine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  selected from the group consisting of Asparagine, Serine and 
       threonine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  selected from the group consisting of Glycine and Serine

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  selected from the group consisting of Cysteine and Phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  selected from the group consisting of Proline and Glutamine

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  selected from the group consisting of Threonine and Arginine

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  selected from the group consisting of Aspartic acid and Glutamine

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  selected from the group consisting of Threonine  and Asparagine

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  selected from the group consisting of Alanine and Asparagine

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  selected from the group consisting of Isoleucine and Valine

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  selected from the group consisting of Serine and Glycine

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  selected from the group consisting of Valine and Alanine

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  selected from the group consisting of Valine and Isoleucine

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  selected from the group consisting of Alanine and Threonine

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  selected from the group consisting of Leucine and Valine

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  selected from the group consisting of Threonine, Asparagine and 
       Serine

<220>
<221>  MISC_FEATURE
<222>  (64)..(64)
<223>  selected from the group consisting of Alanine and Threonine

<400>  34

Gly Asn Pro Gln Pro Ala Xaa Phe Trp Xaa Xaa Glu Gly Ser Gln Xaa 
1               5                   10                  15      


Leu Leu Phe Xaa Xaa Gln Pro Xaa Gln Xaa Xaa Xaa Arg Xaa Ser Val 
            20                  25                  30          


Ser Xaa Xaa Gly Xaa Leu Xaa Ile Thr Xaa Xaa Gln Arg Xaa Asp Xaa 
        35                  40                  45              


Gly Tyr Tyr Xaa Cys Gln Xaa Xaa Xaa Val Ala Gly Ser Ile Leu Xaa 
    50                  55                  60                  


<210>  35
<211>  837
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AbD32836 Fd chain nucleic acid sequence

<400>  35
gaagtgcaat tggtggaaag cggcggtggc ctggtgaaac caggcggcag cctgcgcctg       60

agctgcgccg cctccggatt caccttttct tcttacgctc tgtcttgggt gcgccaggcc      120

ccgggcaaag gtctcgagtg ggtgggccat atcaaatcta aaactgacgg tggtgctact      180

gaatatgccg ccccagtgaa aggccgcttt accattagcc gcgatgattc gaaaaacacc      240

ctgtatctgc aaatgaacag cctgaaaacc gaagatacgg ccgtgtatta ttgcgcgcgt      300

tcttactctg aatacatccc gctgtacgct ttcgctgttt ggggccaagg caccctggtg      360

actgttagct cagcgtcgac caaaggcccg agcgtgtttc cgctggcccc gagcagcaaa      420

agcaccagcg gcggcaccgc cgcactgggc tgcctggtga aagattattt cccggaacca      480

gtgaccgtga gctggaacag cggtgccctg accagcggcg tgcatacctt tccggcggtg      540

ctgcaaagca gcggcctgta tagcctgagc agcgttgtga ccgtgccgag cagcagcctg      600

ggcacccaga cctatatttg caacgtcaac cataaaccga gcaacaccaa agtcgataaa      660

aaagtcgaac cgaaaagcga attcggtggc gcgccgggca aaccgattcc gaatccgctg      720

ctgggcctgg atagcaccga tgcgccgagc gcgtggagcc atccgcagtt tgaaaaaggt      780

ggcggttctg gtggcggttc tggtggctcc gcgtggtcgc atccacaatt cgagaag         837


<210>  36
<211>  645
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AbD32836 Light chain nucleic acid sequence

<400>  36
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgtgaccatt       60

agctgtagcg gcagcagcag caacattggt tctaaatacg tgtcttggta ccagcagctg      120

ccgggcacgg cgccgaaact gctgatctac tacacttctc agcgcccgag cggcgtgccg      180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa      240

gcagaagacg aagcggatta ttactgctac gcttgggact ctacttctac ttctactgtg      300

tttggcggcg gcacgaagtt aaccgttctt ggccagccga aagccgcccc aagcgtgacc      360

ctgtttccgc cgagcagcga agaactgcaa gccaacaaag ccaccctggt ttgcctgatc      420

agcgattttt atccgggtgc cgtgaccgtg gcctggaaag ccgatagcag cccggtgaaa      480

gccggcgtgg aaaccaccac cccgagcaaa cagagcaaca acaaatatgc cgccagcagc      540

tatctgagcc tgaccccgga acagtggaaa agccatcgca gctatagttg tcaagtgacc      600

catgaaggca gcaccgtgga aaaaaccgtg gccccgaccg aggcc                      645


