                         SEQUENCE LISTING

<110>  Synpromics Limited
 
<120>  Expression Control Using Regulatable Intron

<130>  P241689WO

<150>  GB1713545.0
<151>  2017-08-23

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  RNA
<213>  Unknown

<220>
<223>  sequence of mammalian XBP1 intron inside of the IRE 1 cleavage 
       sites

<400>  1
cacucagacu acgugcaccu                                                   20


<210>  2
<211>  20
<212>  RNA
<213>  Unknown

<220>
<223>  variant of mammalian XBP1 intron inside of the IRE 1 cleavage 
       sites

<400>  2
cacucagacu acgugcuccu                                                   20


<210>  3
<211>  20
<212>  RNA
<213>  Unknown

<220>
<223>  variant of mammalian XBP1 intron inside of the IRE 1 cleavage 
       sites

<400>  3
cacucagacu acgugccccu                                                   20


<210>  4
<211>  20
<212>  RNA
<213>  Unknown

<220>
<223>  variant of mammalian XBP1 intron inside of the IRE 1 cleavage 
       sites

<400>  4
cacucagacu acgugcgccu                                                   20


<210>  5
<211>  20
<212>  RNA
<213>  Unknown

<220>
<223>  variant of mammalian XBP1 intron inside of the IRE 1 cleavage 
       sites

<400>  5
cacucagacu augugcaccu                                                   20


<210>  6
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  regulatable intron


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  n is a, c, g, or u

<400>  6
cngcngcacu cagacuacgu gcaccucngc ngc                                    33


<210>  7
<211>  33
<212>  RNA
<213>  Unknown

<220>
<223>  mammalian XBP1 intron sequence

<400>  7
cagcagcacu cagacuacgu gcaccucugc ugc                                    33


<210>  8
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  regulatable intron


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  n is a, c, g, or u

<400>  8
cngcagcacu cagacuacgu gcaccucugc ng                                     32


<210>  9
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  regulatable intron


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  n is a, c, g, or u

<400>  9
cngcagcacu cagacuacgu gcuccucugc ng                                     32


<210>  10
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  regulatable intron


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  n is a, c, g, or u

<400>  10
cngcagcacu cagacuacgu gccccucugc ng                                     32


<210>  11
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  regulatable intron


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  n is a, c, g, or u

<400>  11
cngcagcacu cagacuacgu gcgccucugc ng                                     32


<210>  12
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  regulatable intron


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  n is a, c, g, or u

<400>  12
cngcagcacu cagacuaugu gcaccucugc ng                                     32


<210>  13
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  regulatable intron

<400>  13
cagcagcacu cagacuacgu gcuccucugc ugc                                    33


<210>  14
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  regulatable intron

<400>  14
cagcagcacu cagacuacgu gccccucugc ugc                                    33


<210>  15
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  regulatable intron

<400>  15
cagcagcacu cagacuacgu gcgccucugc ugc                                    33


<210>  16
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  regulatable intron

<400>  16
cagcagcacu cagacuaugu gcaccucugc ugc                                    33


<210>  17
<211>  35
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mammalian XBP1 intron sequence with addition of trinucleotide CUG

<400>  17
cagcugcagc acucagacua cgugcaccuc ugcag                                  35


<210>  18
<211>  19
<212>  DNA
<213>  Unknown

<220>
<223>  ERSE1 site


<220>
<221>  misc_feature
<222>  (6)..(14)
<223>  n is a, c, g, or t

<400>  18
ccaatnnnnn nnnnccacg                                                    19


<210>  19
<211>  11
<212>  DNA
<213>  Unknown

<220>
<223>  ERSE2 site


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, or t

<400>  19
attggnccac g                                                            11


<210>  20
<211>  54
<212>  DNA
<213>  Unknown

<220>
<223>  UPR inducible promoter sequence

<400>  20
tgacgtgctt gacgtgcttg acgtgcttga cgtgcttgac gtgcttgacg tgct             54


<210>  21
<211>  84
<212>  DNA
<213>  Unknown

<220>
<223>  CMV-minimal promoter

<400>  21
aggtctatat aagcagagct cgtttagtga accgtcagat cgcctagata cgccatccac       60

gctgttttga cctccataga agat                                              84


<210>  22
<211>  169
<212>  DNA
<213>  Unknown

<220>
<223>  inducible promoter

<400>  22
tgacgtgctt gacgtgcttg acgtgcttga cgtgcttgac gtgcttgacg tgctggtacc       60

gtcgacgata tcggatccag gtctatataa gcagagctcg tttagtgaac cgtcagatcg      120

cctagatacg ccatccacgc tgttttgacc tccatagaag atcgccacc                  169


<210>  23
<211>  26
<212>  RNA
<213>  Unknown

<220>
<223>  mammalian WT intron sequence

<400>  23
cagcacucag acuacgugca ccucug                                            26


<210>  24
<211>  33
<212>  RNA
<213>  Unknown

<220>
<223>  mammalian WT intron sequence flanked by splice recognition site 
       sequnces

<400>  24
ccgcagcacu cagacuacgu gcaccucugc agc                                    33


<210>  25
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EGFP gene with intron insertion

<400>  25
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaag         717


<210>  26
<211>  239
<212>  PRT
<213>  Unknown

<220>
<223>  EGFP protein sequence

<400>  26

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  27
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mammalian XBP1 intron sequence with addition of trinucleotide CUG

<400>  27
cagcugcagc acucagacua cgugcaccuc ugcugg                                 36


<210>  28
<211>  1150
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EGFP sequence with regulatable XBP1 intron, CMV-MP and SV40 polyA
       tail

<400>  28
ggtaccgtcg acgatatcgg atccaggtct atataagcag agctcgttta gtgaaccgtc       60

agatcgccta gatacgccat ccacgctgtt ttgacctcca tagaagatcg ccaccatggt      120

gagcaagggc gaggagctgt tcaccggggt ggtgcccatc ctggtcgagc tggacggcga      180

cgtaaacggc cacaagttca gcgtgtccgg cgagggcgag ggcgatgcca cctacggcaa      240

gctgaccctg aagttcatct gcaccaccgg caagctgccc gtgccctggc ccaccctcgt      300

gaccaccctg acctacggcg tgcagtgctt cagccgctac cccgaccaca tgaagcagca      360

cgacttcttc aagtccgcca tgcccgaagg ctacgtccag gagcgcacca tcttcttcaa      420

ggacgacggc aactacaaga cccgcgccga ggtgaagttc gagggcgaca ccctggtgaa      480

ccgcatcgag ctgaagggca tcgacttcaa ggaggacggc aacatcctgg ggcacaagct      540

ggagtacaac tacaacagcc acaacgtcta tatcatggcc gacaagcaga agaacggcat      600

caaggtgaac ttcaagatcc gccacaacat cgaggacggc agcgtgcagc tgcagcactc      660

agactacgtg cacctctgct ggccgaccac taccagcaga acacccccat cggcgacggc      720

cccgtgctgc tgcccgacaa ccactacctg agcacccagt ccgccctgag caaagacccc      780

aacgagaagc gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg gatcactctc      840

ggcatggacg agctgtacaa gtgagacgat ccttatcgga ttttaccaca tttgtagagg      900

ttttacttgc tttaaaaaac ctcccacatc tccccctgaa cctgaaacat aaaatgaatg      960

caattgttgt tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca     1020

tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac     1080

tcatcaatgt atcttatcat gtctgctcga aggcgcgccc tgggcctcat gggccttccg     1140

ctcactgccc                                                            1150


<210>  29
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated EGFP protein - start to first stop codon

<400>  29

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Glu His Ser Asp Tyr Val His Leu Cys Trp Pro Thr Thr 
            180                 185                 190         


Thr Ser Arg Thr Pro Pro Ser Ala Thr Ala Pro Cys Cys Cys Pro Thr 
        195                 200                 205             


Thr Thr Thr 
    210     


<210>  30
<211>  889
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNP-ATF6-02 construct

<400>  30
tgacgtgctt gacgtgcttg acgtgcttga cgtgcttgac gtgcttgacg tgctggtacc       60

gtcgacgata tcggatccag gtctatataa gcagagctcg tttagtgaac cgtcagatcg      120

cctagatacg ccatccacgc tgttttgacc tccatagaag atcgccacca tggtgagcaa      180

gggcgaggag ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa      240

cggccacaag ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac      300

cctgaagttc atctgcacca ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac      360

cctgacctac ggcgtgcagt gcttcagccg ctaccccgac cacatgaagc agcacgactt      420

cttcaagtcc gccatgcccg aaggctacgt ccaggagcgc accatcttct tcaaggacga      480

cggcaactac aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat      540

cgagctgaag ggcatcgact tcaaggagga cggcaacatc ctggggcaca agctggagta      600

caactacaac agccacaacg tctatatcat ggccgacaag cagaagaacg gcatcaaggt      660

gaacttcaag atccgccaca acatcgagga cggcagcgtg cagctcgccg accactacca      720

gcagaacacc cccatcggcg acggccccgt gctgctgccc gacaaccact acctgagcac      780

ccagtccgcc ctgagcaaag accccaacga gaagcgcgat cacatggtcc tgctggagtt      840

cgtgaccgcc gccgggatca ctctcggcat ggacgagctg tacaagtga                  889


<210>  31
<211>  845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNP-ATF6-02 with excised intron sequence

<400>  31
tgacgtgctt gacgtgcttg acgtgcttga cgtgcttgac gtgcttgacg tgctggtacc       60

gtcgacgata tcggatccag gtctatataa gcagagctcg tttagtgaac cgtcagatcg      120

cctagatacg ccatccacgc tgttttgacc tccatagaag atcgccacca tggtgagcaa      180

gggcgaggag ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa      240

cggccacaag ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac      300

cctgaagttc atctgcacca ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac      360

cctgacctac ggcgtgcagt gcttcagccg ctaccccgac cacatgaagc agcacgactt      420

cttcaagtcc gccatgcccg aaggctacgt ccaggagcgc accatcttct tcaaggacga      480

cggcaactac aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat      540

cgagctgaag ggcatcgact tcaaggagga cggcaacatc ctggggcaca agctggagta      600

caactacaac agccacaacg tctatatcat ggccgacaag cagaagaacg gcatcaaggt      660

gaacttcaag atccgccaca acatcgagga cggcagcgtg cagctggccg accactacca      720

gcagaacacc cccatcggcg acggccccgt gctgctgccc gacaaccact acctgagcac      780

ccagtccgcc ctgagcaaag accccaacga gaagcgcgat cacatggtcc tgctggagtt      840

cgtga                                                                  845


<210>  32
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA coding for excised region of intron

<400>  32
cagacgggca actttacacg acgctg                                            26


<210>  33

<400>  33
000

<210>  34
<211>  1892
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEAP expression construct

<400>  34
tgacgtgctg atgatgcgta gctagtagtt gacgtgctga tgatgcgtag ctagtagttg       60

acgtgctgat gatgcgtagc tagtagttga cgtgctgatg atgcgtagct agtagttgac      120

gtgctgatga tgcgtagcta gtagttgacg tgctgatgat gcgtagctag tagtgcagtt      180

agcgtagctg aggtaccgtc gacgatatcg gatccaggtc tatataagca gagctcgttt      240

agtgaaccgt cagatcgcct agatacgcca tccacgctgt tttgacctcc atagaagatc      300

gccaccatgc tgctgctgct gctgctgctg ggcctgaggc tacagctctc cctgggcatc      360

atcccagttg aggaggagaa cccggacttc tggaaccgcg aggcagccga ggccctgggt      420

gccgccaaga agctgcagcc tgcacagaca gccgccaaga acctcatcat cttcctgggc      480

gatgggatgg gggtgtctac ggtgacagct gccaggatcc taaaagggca gaagaaggac      540

aaactggggc ctgagatacc cctggctatg gaccgcttcc catatgtggc tctgtccaag      600

acatacaatg tagacaaaca tgtgccagac agtggagcca cagccacggc ctacctgtgc      660

ggggtcaagg gcaacttcca gaccattggc ttgagtgcag ccgcccgctt taaccagtgc      720

aacacgacac gcggcaacga ggtcatctcc gtgatgaatc gggccaagaa agcagggaag      780

tcagtgggag tggtaaccac cacacgagtg cagcacgcct cgccagccgg cacctacgcc      840

cacacggtga accgcaactg gtactcggac gccgacgtgc ctgcctcggc ccgccaggag      900

gggtgccagg acatcgctac gcagctcatc tccaacatgg acattgacgt gatcctaggt      960

ggaggccgaa agtacatgtt tcgcatggga accccagacc ctgagtaccc agatgactac     1020

agccaaggtg ggaccaggct ggacgggaag aatctggtgc aggaatggct ggcgaagcgc     1080

cagggtgccc ggtatgtgtg gaaccgcact gagctcatgc aggcttccct ggacccgtct     1140

gtgacccatc tcatgggcct ctttgagcct ggagacatga aatacgagat ccaccgagac     1200

tccacactgg acccctccct gatggagatg acagaggctg ccctgcgcct gctgagcagg     1260

aacccccgcg gcttcttcct cttcgtggag ggtggtcgca tcgaccacgg tcatcatgaa     1320

agcagggctt accgggcact gactgaaacg atcatgttcg acgacgccat tgagagggcg     1380

ggccagctca ccagcgagga ggacacgctg agcctcgtca ctgccgacca ctcccacgtc     1440

ttctccttcg gaggctaccc cctgcgaggg agctccatct tcgggctggc ccctggcaag     1500

gcccgggaca ggaaggccta cacggtcctc ctatacggaa acggtccagg ctatgtgctc     1560

aaggacggcg cccggccgga tgttaccgag agcgagagcg ggagccccga gtatcggcag     1620

cagacgggca actttacacg acgctgcagt cagcagtgcc cctggacgaa gagacacacg     1680

caggcgagga cgtggcggtg ttcgcgcgcg gcccgcaggc gcacctggtt cacggcgtgc     1740

aggagcagac cttcatagcg cacgtcatgg ccttcgccgc ctgcctggag ccctacaccg     1800

cctgcgacct ggcgcccccc gccggcacca ccgacgccgc gcacccgggt tactctagag     1860

tcggggcggc cggccgcttc gagcagacat ga                                   1892


<210>  35
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated SEAP protein

<400>  35

Met Leu Leu Leu Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu Ser Leu 
1               5                   10                  15      


Gly Ile Ile Pro Val Glu Glu Glu Asn Pro Asp Phe Trp Asn Arg Glu 
            20                  25                  30          


Ala Ala Glu Ala Leu Gly Ala Ala Lys Lys Leu Gln Pro Ala Gln Thr 
        35                  40                  45              


Ala Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp Gly Met Gly Val Ser 
    50                  55                  60                  


Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Lys Lys Asp Lys Leu 
65                  70                  75                  80  


Gly Pro Glu Ile Pro Leu Ala Met Asp Arg Phe Pro Tyr Val Ala Leu 
                85                  90                  95      


Ser Lys Thr Tyr Asn Val Asp Lys His Val Pro Asp Ser Gly Ala Thr 
            100                 105                 110         


Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Phe Gln Thr Ile Gly 
        115                 120                 125             


Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg Gly Asn 
    130                 135                 140                 


Glu Val Ile Ser Val Met Asn Arg Ala Lys Lys Ala Gly Lys Ser Val 
145                 150                 155                 160 


Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala Gly Thr 
                165                 170                 175     


Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp Val Pro 
            180                 185                 190         


Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln Leu Ile 
        195                 200                 205             


Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys Tyr Met 
    210                 215                 220                 


Phe Arg Met Gly Thr Pro Asp Pro Glu Tyr Pro Asp Asp Tyr Ser Gln 
225                 230                 235                 240 


Gly Gly Thr Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp Leu Ala 
                245                 250                 255     


Lys Arg Gln Gly Ala Arg Tyr Val Trp Asn Arg Thr Glu Leu Met Gln 
            260                 265                 270         


Ala Ser Leu Asp Pro Ser Val Thr His Leu Met Gly Leu Phe Glu Pro 
        275                 280                 285             


Gly Asp Met Lys Tyr Glu Ile His Arg Asp Ser Thr Leu Asp Pro Ser 
    290                 295                 300                 


Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg Asn Pro 
305                 310                 315                 320 


Arg Gly Phe Phe Leu Phe Val Glu Gly Gly Arg Ile Asp His Gly His 
                325                 330                 335     


His Glu Ser Arg Ala Tyr Arg Ala Leu Thr Glu Thr Ile Met Phe Asp 
            340                 345                 350         


Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp Thr Leu 
        355                 360                 365             


Ser Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly Gly Tyr 
    370                 375                 380                 


Pro Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Gly Lys Ala Arg 
385                 390                 395                 400 


Asp Arg Lys Ala Tyr Thr Val Leu Leu Tyr Gly Asn Gly Pro Gly Tyr 
                405                 410                 415     


Val Leu Lys Asp Gly Ala Arg Pro Asp Val Thr Glu Ser Glu Ser Gly 
            420                 425                 430         


Ser Pro Glu Tyr Arg Gln Gln Thr Gly Asn Phe Thr Arg Arg Cys Ser 
        435                 440                 445             


Gln Gln Cys Pro Trp Thr Lys Arg His Thr Gln Ala Arg Thr Trp Arg 
    450                 455                 460                 


Cys Ser Arg Ala Ala Arg Arg Arg Thr Trp Phe Thr Ala Cys Arg Ser 
465                 470                 475                 480 


Arg Pro Ser 
            


<210>  36
<211>  519
<212>  PRT
<213>  Unknown

<220>
<223>  full length SEAP protein

<400>  36

Met Leu Leu Leu Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu Ser Leu 
1               5                   10                  15      


Gly Ile Ile Pro Val Glu Glu Glu Asn Pro Asp Phe Trp Asn Arg Glu 
            20                  25                  30          


Ala Ala Glu Ala Leu Gly Ala Ala Lys Lys Leu Gln Pro Ala Gln Thr 
        35                  40                  45              


Ala Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp Gly Met Gly Val Ser 
    50                  55                  60                  


Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Lys Lys Asp Lys Leu 
65                  70                  75                  80  


Gly Pro Glu Ile Pro Leu Ala Met Asp Arg Phe Pro Tyr Val Ala Leu 
                85                  90                  95      


Ser Lys Thr Tyr Asn Val Asp Lys His Val Pro Asp Ser Gly Ala Thr 
            100                 105                 110         


Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Phe Gln Thr Ile Gly 
        115                 120                 125             


Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg Gly Asn 
    130                 135                 140                 


Glu Val Ile Ser Val Met Asn Arg Ala Lys Lys Ala Gly Lys Ser Val 
145                 150                 155                 160 


Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala Gly Thr 
                165                 170                 175     


Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp Val Pro 
            180                 185                 190         


Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln Leu Ile 
        195                 200                 205             


Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys Tyr Met 
    210                 215                 220                 


Phe Arg Met Gly Thr Pro Asp Pro Glu Tyr Pro Asp Asp Tyr Ser Gln 
225                 230                 235                 240 


Gly Gly Thr Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp Leu Ala 
                245                 250                 255     


Lys Arg Gln Gly Ala Arg Tyr Val Trp Asn Arg Thr Glu Leu Met Gln 
            260                 265                 270         


Ala Ser Leu Asp Pro Ser Val Thr His Leu Met Gly Leu Phe Glu Pro 
        275                 280                 285             


Gly Asp Met Lys Tyr Glu Ile His Arg Asp Ser Thr Leu Asp Pro Ser 
    290                 295                 300                 


Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg Asn Pro 
305                 310                 315                 320 


Arg Gly Phe Phe Leu Phe Val Glu Gly Gly Arg Ile Asp His Gly His 
                325                 330                 335     


His Glu Ser Arg Ala Tyr Arg Ala Leu Thr Glu Thr Ile Met Phe Asp 
            340                 345                 350         


Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp Thr Leu 
        355                 360                 365             


Ser Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly Gly Tyr 
    370                 375                 380                 


Pro Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Gly Lys Ala Arg 
385                 390                 395                 400 


Asp Arg Lys Ala Tyr Thr Val Leu Leu Tyr Gly Asn Gly Pro Gly Tyr 
                405                 410                 415     


Val Leu Lys Asp Gly Ala Arg Pro Asp Val Thr Glu Ser Glu Ser Gly 
            420                 425                 430         


Ser Pro Glu Tyr Arg Gln Gln Ser Ala Val Pro Leu Asp Glu Glu Thr 
        435                 440                 445             


His Ala Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln Ala His 
    450                 455                 460                 


Leu Val His Gly Val Gln Glu Gln Thr Phe Ile Ala His Val Met Ala 
465                 470                 475                 480 


Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala Pro Pro 
                485                 490                 495     


Ala Gly Thr Thr Asp Ala Ala His Pro Gly Tyr Ser Arg Val Gly Ala 
            500                 505                 510         


Ala Gly Arg Phe Glu Gln Thr 
        515                 


<210>  37
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  regulatable intron

<400>  37
cagacgggca acuuuacacg acgcug                                            26


<210>  38
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  intron inserted in luciferase coding sequence

<400>  38
ccgcagacgg gcaactttac acgacgctgc ag                                     32


<210>  39
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated luciferase protein

<400>  39

Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Asp Gly Gln Leu Tyr Thr Thr Leu Gln Thr Ser Cys Trp 
                485                 490                 495     


Asn Thr Val Lys Pro 
            500     


<210>  40
<211>  550
<212>  PRT
<213>  Unknown

<220>
<223>  full length luciferase protein

<400>  40

Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Asp Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val 
545                 550 


<210>  41
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  INTC9FP intron

<400>  41
acgtcagacg ggcaacttta cacgacgctg                                        30


<210>  42
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  INTC9RP intron sequence

<400>  42
acgtcagcgt cgtgtaaagt tgcccgtctg                                        30


<210>  43
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Regulatable intron insered in caspase 9 coding sequence

<400>  43
cagcagacgg gcaactttac acgacgctgc tg                                     32


<210>  44
<211>  8008
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNP-CASP9-INT vector with intron construct

<400>  44
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg agtacattta tattggctca tgtccaatat      240

gaccgccatg ttgacattga ttattgacta gttattaata gtaatcaatt acggggtcat      300

tagttcatag cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg      360

gctgaccgcc caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa      420

cgccaatagg gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact      480

tggcagtaca tcaagtgtat catatgccaa gtccgccccc tattgacgtc aatgacggta      540

aatggcccgc ctggcattat gcccagtaca tgaccttacg ggactttcct acttggcagt      600

acatctacgt attagtcatc gctattacca tggtgatgcg gttttggcag tacaccaatg      660

ggcgtggata gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg      720

ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaat aaccccgccc      780

cgttgacgca aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcgtt      840

tagtgaaccg tcagatcctc actctcttcc gcatcgctgt ctgcgagggc cagctgttgg      900

gctcgcggtt gaggacaaac tcttcgcggt ctttccagta ctcttggatc ggaaacccgt      960

cggcctccga acggtactcc gccaccgagg gacctgagcg agtccgcatc gaccggatcg     1020

gaaaacctct cgagaaaggc gtctaaccag tcacagtcgc aaggtaggct gagcaccgtg     1080

gcgggcggca gcgggtggcg gtcggggttg tttctggcgg aggtgctgct gatgatgtaa     1140

ttaaagtagg cggtcttgag acggcggatg gtcgaggtga ggtgtgggtt tagtgaaccg     1200

tcagatcctc actctcttcc gcatcgctgt ctgcgagggc cagctgtcag gcttgagatc     1260

cagctgttgg ggtgagtact ccctctcaaa agcgggcatt acttctgcgc taagattgtc     1320

agtttccaaa aacgaggagg atttgatatt cacctggccc gatctggcca tacacttgag     1380

tgacaatgac atccactttg cctttctctc cacaggtgtc cactcccagg tccaagttta     1440

aactttaata cgactcacta taggggccgc caccaagctt ggtacatgga cgaagcggat     1500

cggcggctcc tgcggcggtg ccggctgcgg ctggtggaag agctgcaggt ggaccagctc     1560

tgggacgccc tgctgagccg cgagctgttc aggccccata tgatcgagga catccagcgg     1620

gcaggctctg gatctcggcg ggatcaggcc aggcagctga tcatagatct ggagactcga     1680

gggagtcagg ctcttccttt gttcatctcc tgcttagagg acacaggcca ggacatgctg     1740

gcttcgtttc tgcgaactaa caggcaagca gcaaagttgt cgaagccaac cctagaaaac     1800

cttaccccag tggtgctcag accagagatt cgcaaaccag aggttctcag accggaaaca     1860

cccagaccag tggacattgg ttctggagga ttcggtgatg tcggtgctct tgagagtttg     1920

aggggaaatg cagatttggc ttacatcctg agcatggagc cctgtggcca ctgcctcatt     1980

atcaacaatg tgaacttctg ccgtgagtcc gggctccgca cccgcactgg ctccaacatc     2040

gactgtgaga agttgcggcg tcgcttctcc tcgctgcatt tcatggtgga ggtgaagggc     2100

gacctgactg ccaagaaaat ggtgctggct ttgctggagc tggcgcagca ggaccacggt     2160

gctctggact gctgcgtggt ggtcattctc tctcacggct gtcaggccag ccacctgcag     2220

ttcccagggg ctgtctacgg cacagatgga tgccctgtgt cggtcgagaa gattgtgaac     2280

atcttcaatg ggaccagctg ccccagcctg ggagggaagc ccaagctctt tttcatccag     2340

gcctgtggtg gggagcagaa agaccatggg tttgaggtgg cctccacttc ccctgaagac     2400

gagtcccctg gcagtaaccc cgagccagat gccaccccgt tccaggaagg tttgaggacc     2460

ttcgaccagc tggacgccat atctagtttg cccacaccca gtgacatctt tgtgtcctac     2520

tctactttcc caggttttgt ttcctggagg gaccccaaga gtggctcctg gtcagacggg     2580

caactttaca cgacgctgga gaccctggac gacatctttg agcagtgggc tcactctgaa     2640

gacctgcagt ccctcctgct tagggtcgct aatgctgttt cggtgaaagg gatttataaa     2700

cagatgcctg gttgctttaa tttcctccga aaaaaacttt tctttaaaac atcagggggt     2760

ggaggctctg tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag     2820

ctggacggcg acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc     2880

acctacggca agctgaccct gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg     2940

cccaccctcg tgaccaccct gacctacggc gtgcagtgct tcagccgcta ccccgaccac     3000

atgaagaagc acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc     3060

atcttcttca aggacgacgg caactacaag acccgcgccg aggtgaagtt cgagggcgac     3120

accctggtga accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg     3180

gggcacaagc tggagtacaa ctacaacagc cacaacgtct atatcatggc cgacaagcag     3240

aagaacggca tcaaggctaa cttcaaggtt cgccacaaca tcgaggacgg cagcgtgcag     3300

ctcgccgacc actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac     3360

aaccactacc tgagcaccca gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac     3420

atggtcctgc tggagttcgt gaccgccgcc gggatcactc tcggcatgga cgagctgtac     3480

aagtaaactc gagtctagag cggccgccga attcgggccc gtttaaaccc gctgatcagc     3540

ctcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt     3600

gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca     3660

ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga     3720

ggattgggaa gacaatagca ggcatgctgg ggatgcggtg ggctctatgg cttctgaggc     3780

ggaaagaacc agctggggct ctagggggta tccccacgcg ccctgtagcg gcgcattaag     3840

cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc     3900

cgctcctttc gctttcttcc cttcctttct cgccacgttc gcaggctttc cccgtcaagc     3960

tctaaatcgg gggctccctt tagggttccg atttagtgct ttacggcacc tcgaccccaa     4020

aaaacttgat tagggtgatg gttcacgtag tgggccatcg ccctgataga cggtttttcg     4080

ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac     4140

actcaaccct atctcggtct attcttttga tttataaggg attttgccga tttcggccta     4200

ttggttaaaa aatgagctga tttaacaaaa atttaacgcg aattaattct gtggaatgtg     4260

tgtcagttag ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg     4320

catctcaatt agtcagcaac caggtgtgga aagtccccag gctccccagc aggcagaagt     4380

atgcaaagca tgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc     4440

ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt     4500

atttatgcag aggccgaggc cgcctctgcc tctgagctat tccagaagta gtgaggaggc     4560

ttttttggag gcctaggctt ttgcaaaaag ctctcgggag cttgtatatc cattttcgga     4620

tctgatcagc acgtgatgaa aaagcctgaa ctcaccgcga cgtctgtcga gaagtttctg     4680

atcgaaaagt tcgacagcgt ctccgacctg atgcagctct cggagggcga agaatctcgt     4740

gctttcagct tcgatgtagg agggcgtgga tatgtcctgc gggtaaatag ctgcgccgat     4800

ggtttctaca aagatcgtta tgtttatcgg cactttgcat cggccgcgct cccgattccg     4860

gaagtgcttg acattgggga attcagcgag agcctgacct attgcatctc ccgccgtgca     4920

cagggtgtca cgttgcaaga cctgcctgaa accgaactgc ccgctgttct gcagccggtc     4980

gcggaggcca tggatgcgat cgctgcggcc gatcttagcc agacgagcgg gttcggccca     5040

ttcggaccgc aaggaatcgg tcaatacact acatggcgtg atttcatatg cgcgattgct     5100

gatccccatg tgtatcactg gcaaactgtg atggacgaca ccgtcagtgc gtccgtcgcg     5160

caggctctcg atgagctgat gctttgggcc gaggactgcc ccgaagtccg gcacctcgtg     5220

cacgcggatt tcggctccaa caatgtcctg acggacaatg gccgcataac agcggtcatt     5280

gactggagcg aggcgatgtt cggggattcc caatacgagg tcgccaacat cttcttctgg     5340

aggccgtggt tggcttgtat ggagcagcag acgcgctact tcgagcggag gcatccggag     5400

cttgcaggat cgccgcggct ccgggcgtat atgctccgca ttggtcttga ccaactctat     5460

cagagcttgg ttgacggcaa tttcgatgat gcagcttggg cgcagggtcg atgcgacgca     5520

atcgtccgat ccggagccgg gactgtcggg cgtacacaaa tcgcccgcag aagcgcggcc     5580

gtctggaccg atggctgtgt agaagtactc gccgatagtg gaaaccgacg ccccagcact     5640

cgtccgaggg caaaggaata gcacgtgcta cgagatttcg attccaccgc cgccttctat     5700

gaaaggttgg gcttcggaat cgttttccgg gacgctggct ggatgatcct ccagcgcggg     5760

gatctcatgc tggagttctt cgcccacccc aacttgttta ttgcagctta taatggttac     5820

aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt     5880

tgtggtttgt ccaaactcat caatgtatct tatcatgtct gtataccgtc gacctctagc     5940

tagagcttgg cgtaatcatg gtcatagctg tttcctgtgt gaaattgtta tccgctcaca     6000

attccacaca acatacgagc cggaagcata aagtgtaaag cctggggtgc ctaatgagtg     6060

agctaactca cattaattgc gttgcgctca ctgcccgctt tccagtcggg aaacctgtcg     6120

tgccagctgc attaatgaat cggccaacgc gcggggagag gcggtttgcg tattgggcgc     6180

tcttccgctt cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta     6240

tcagctcact caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag     6300

aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg     6360

tttttccata ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg     6420

tggcgaaacc cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg     6480

cgctctcctg ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga     6540

agcgtggcgc tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc     6600

tccaagctgg gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt     6660

aactatcgtc ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact     6720

ggtaacagga ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg     6780

cctaactacg gctacactag aagaacagta tttggtatct gcgctctgct gaagccagtt     6840

accttcggaa aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt     6900

ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct     6960

ttgatctttt ctacggggtc tgagcgcgga acccctattt gtttattttt ctaaatacat     7020

tcaaatatgt atccgctcat gaattaattc ttagaaaaac tcatcgagca tcaaatgaaa     7080

ctgcaattta ttcatatcag gattatcaat accatatttt tgaaaaagcc gtttctgtaa     7140

tgaaggagaa aactcaccga ggcagttcca taggatggca agatcctggt atcggtctgc     7200

gattccgact cgtccaacat caatacaacc tattaatttc ccctcgtcaa aaataaggtt     7260

atcaagtgag aaatcaccat gagtgacgac tgaatccggt gagaatggca aaagtttatg     7320

catttctttc cagacttgtt caacaggcca gccattacgc tcgtcatcaa aatcactcgc     7380

atcaaccaaa ccgttattca ttcgtgattg cgcctgagcg agacgaaata cgcgatcgct     7440

gttaaaagga caattacaaa caggaatcga atgcaaccgg cgcaggaaca ctgccagcgc     7500

atcaacaata ttttcacctg aatcaggata ttcttctaat acctggaatg ctgttttccc     7560

agggatcgca gtggtgagta accatgcatc atcaggagta cggataaaat gcttgatggt     7620

cggaagaggc ataaattccg tcagccagtt tagtctgacc atctcatctg taacatcatt     7680

ggcaacgcta cctttgccat gtttcagaaa caactctggc gcatcgggct tcccatacaa     7740

tcgatagatt gtcgcacctg attgcccgac attatcgcga gcccatttat acccatataa     7800

atcagcatcc atgttggaat ttaatcgcgg cctagagcaa gacgtttccc gttgaatatg     7860

gctcataaca ccccttgtat tactgtttat gtaagcagac agttttattg ttcatgacca     7920

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa atccgcgcac     7980

atttccccga aaagtgccac ctgacgtc                                        8008


<210>  45
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated caspase 9

<400>  45

Met Asp Glu Ala Asp Arg Arg Leu Leu Arg Arg Cys Arg Leu Arg Leu 
1               5                   10                  15      


Val Glu Glu Leu Gln Val Asp Gln Leu Trp Asp Ala Leu Leu Ser Arg 
            20                  25                  30          


Glu Leu Phe Arg Pro His Met Ile Glu Asp Ile Gln Arg Ala Gly Ser 
        35                  40                  45              


Gly Ser Arg Arg Asp Gln Ala Arg Gln Leu Ile Ile Asp Leu Glu Thr 
    50                  55                  60                  


Arg Gly Ser Gln Ala Leu Pro Leu Phe Ile Ser Cys Leu Glu Asp Thr 
65                  70                  75                  80  


Gly Gln Asp Met Leu Ala Ser Phe Leu Arg Thr Asn Arg Gln Ala Ala 
                85                  90                  95      


Lys Leu Ser Lys Pro Thr Leu Glu Asn Leu Thr Pro Val Val Leu Arg 
            100                 105                 110         


Pro Glu Ile Arg Lys Pro Glu Val Leu Arg Pro Glu Thr Pro Arg Pro 
        115                 120                 125             


Val Asp Ile Gly Ser Gly Gly Phe Gly Asp Val Gly Ala Leu Glu Ser 
    130                 135                 140                 


Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys 
145                 150                 155                 160 


Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly 
                165                 170                 175     


Leu Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg 
            180                 185                 190         


Arg Phe Ser Ser Leu His Phe Met Val Glu Val Lys Gly Asp Leu Thr 
        195                 200                 205             


Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His 
    210                 215                 220                 


Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu Ser His Gly Cys Gln 
225                 230                 235                 240 


Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys 
                245                 250                 255     


Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys 
            260                 265                 270         


Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly 
        275                 280                 285             


Gly Glu Gln Lys Asp His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu 
    290                 295                 300                 


Asp Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln 
305                 310                 315                 320 


Glu Gly Leu Arg Thr Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro 
                325                 330                 335     


Thr Pro Ser Asp Ile Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val 
            340                 345                 350         


Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp Ser Ala Gly Asp Pro Gly 
        355                 360                 365             


Arg His Leu 
    370     


<210>  46
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full length caspase 9

<400>  46

Met Asp Glu Ala Asp Arg Arg Leu Leu Arg Arg Cys Arg Leu Arg Leu 
1               5                   10                  15      


Val Glu Glu Leu Gln Val Asp Gln Leu Trp Asp Ala Leu Leu Ser Arg 
            20                  25                  30          


Glu Leu Phe Arg Pro His Met Ile Glu Asp Ile Gln Arg Ala Gly Ser 
        35                  40                  45              


Gly Ser Arg Arg Asp Gln Ala Arg Gln Leu Ile Ile Asp Leu Glu Thr 
    50                  55                  60                  


Arg Gly Ser Gln Ala Leu Pro Leu Phe Ile Ser Cys Leu Glu Asp Thr 
65                  70                  75                  80  


Gly Gln Asp Met Leu Ala Ser Phe Leu Arg Thr Asn Arg Gln Ala Ala 
                85                  90                  95      


Lys Leu Ser Lys Pro Thr Leu Glu Asn Leu Thr Pro Val Val Leu Arg 
            100                 105                 110         


Pro Glu Ile Arg Lys Pro Glu Val Leu Arg Pro Glu Thr Pro Arg Pro 
        115                 120                 125             


Val Asp Ile Gly Ser Gly Gly Phe Gly Asp Val Gly Ala Leu Glu Ser 
    130                 135                 140                 


Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys 
145                 150                 155                 160 


Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly 
                165                 170                 175     


Leu Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg 
            180                 185                 190         


Arg Phe Ser Ser Leu His Phe Met Val Glu Val Lys Gly Asp Leu Thr 
        195                 200                 205             


Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His 
    210                 215                 220                 


Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu Ser His Gly Cys Gln 
225                 230                 235                 240 


Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys 
                245                 250                 255     


Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys 
            260                 265                 270         


Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly 
        275                 280                 285             


Gly Glu Gln Lys Asp His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu 
    290                 295                 300                 


Asp Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln 
305                 310                 315                 320 


Glu Gly Leu Arg Thr Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro 
                325                 330                 335     


Thr Pro Ser Asp Ile Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val 
            340                 345                 350         


Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp Ser Ala Asp Gly Gln Leu 
        355                 360                 365             


Tyr Thr Thr Leu Leu Glu Thr Leu Asp Asp Ile Phe Glu Gln Trp Ala 
    370                 375                 380                 


His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala Val 
385                 390                 395                 400 


Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn Phe Leu 
                405                 410                 415     


Arg Lys Lys Leu Phe Phe Lys Thr Ser Gly Gly Gly Gly Ser 
            420                 425                 430 


<210>  47
<211>  154
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UPR inducible promoter

<400>  47
tgacgtgctg atgatgcgta gctagtagtt gacgtgctga tgatgcgtag ctagtagttg       60

acgtgctgat gatgcgtagc tagtagttga cgtgctgatg atgcgtagct agtagttgac      120

gtgctgatga tgcgtagcta gtagttgacg tgct                                  154


<210>  48
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Regulatable intron

<400>  48
cagctgcagc actcagacta cgtgcacctc tgctg                                  35


<210>  49
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  intron sequence inside cleavage sites

<400>  49
acgggcaacu uuacacgacg                                                   20


<210>  50
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  regulatable intron sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  n is a, c, g, or u

<400>  50
cngcagacgg gcaacuuuac acgacgcugc ng                                     32


<210>  51
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated EGFP protein -  first stop codon to second stop codon

<400>  51

Ala Pro Ser Pro Pro 
1               5   


<210>  52
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated EGFP protein - from second stop codon to third stop 
       codon

<400>  52

Ala Lys Thr Pro Thr Arg Ser Ala Ile Thr Trp Ser Cys Trp Ser Ser 
1               5                   10                  15      


<210>  53
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated EGFP protein from third stop codon to end of protein

<400>  53

Pro Pro Pro Gly Ser Leu Ser Ala Trp Thr Ser Cys Thr 
1               5                   10              


<210>  54
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UPR-responsive CRE


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  optional spacer sequence

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  optional spacer sequence

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  optional spacer sequence

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  optional spacer sequence

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  optional spacer sequence

<400>  54
tgacgtgntg acgtgntgac gtgntgacgt gntgacgtgn tgacgtg                     47


<210>  55
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UPR-responsive CRE


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Optional spacer sequence

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Optional spacer sequence

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Optional spacer sequence

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Optional spacer sequence

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  Optional spacer sequence

<400>  55
tgacgtgctn tgacgtgctn tgacgtgctn tgacgtgctn tgacgtgctn tgacgtgct        59


<210>  56
<211>  154
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UPR-responsive CRE

<400>  56
tgacgtgctg atgatgcgta gctagtagtt gacgtgctga tgatgcgtag ctagtagttg       60

acgtgctgat gatgcgtagc tagtagttga cgtgctgatg atgcgtagct agtagttgac      120

gtgctgatga tgcgtagcta gtagttgacg tgct                                  154


<210>  57
<211>  255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UPR-inducible promoter

<400>  57
tgacgtgctg atgatgcgta gctagtagtt gacgtgctga tgatgcgtag ctagtagttg       60

acgtgctgat gatgcgtagc tagtagttga cgtgctgatg atgcgtagct agtagttgac      120

gtgctgatga tgcgtagcta gtagttgacg tgctgatgat gcgtagctag tagtgcagtt      180

agcgtagctg aggtaccgtc gacgatatcg gatccaggtc tatataagca gagctcgttt      240

agtgaaccgt cagat                                                       255


<210>  58
<211>  255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UPR-inducible promoter

<400>  58
tgacgtgctg atgatgcgta gctagtagtt gacgtgctga tgatgcgtag ctagtagttg       60

acgtgctgat gatgcgtagc tagtagttga cgtgctgatg atgcgtagct agtagttgac      120

gtgctgatga tgcgtagcta gtagttgacg tgctgatgat gcgtagctag tagtgcagtt      180

agcgtagctg aggtaccgtc gacgatatcg gatccttcgc atattaaggt gacgcgtgtg      240

gcctcgaaca ccgag                                                       255


<210>  59
<211>  2269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct ATF06-MP-001

<400>  59
gaagttccta ttccgaagtt cctattctct agaaagtata ggaacttctg acgtgctgat       60

gatgcgtagc tagtagttga cgtgctgatg atgcgtagct agtagttgac gtgctgatga      120

tgcgtagcta gtagttgacg tgctgatgat gcgtagctag tagttgacgt gctgatgatg      180

cgtagctagt agttgacgtg ctgatgatgc gtagctagta gtgcagttag cgtagctgag      240

gtaccgtcga cgatatcgga tccttcgcat attaaggtga cgcgtgtggc ctcgaacacc      300

gagcgaccct gcagcgaccc gcttaaatgg aagatgccaa aaacattaag aagggcccag      360

cgccattcta cccactcgaa gacgggaccg ccggcgagca gctgcacaaa gccatgaagc      420

gctacgccct ggtgcccggc accatcgcct ttaccgacgc acatatcgag gtggacatta      480

cctacgccga gtacttcgag atgagcgttc ggctggcaga agctatgaag cgctatgggc      540

tgaatacaaa ccatcggatc gtggtgtgca gcgagaatag cttgcagttc ttcatgcccg      600

tgttgggtgc cctgttcatc ggtgtggctg tggccccagc taacgacatc tacaacgagc      660

gcgagctgct gaacagcatg ggcatcagcc agcccaccgt cgtattcgtg agcaagaaag      720

ggctgcaaaa gatcctcaac gtgcaaaaga agctaccgat catacaaaag atcatcatca      780

tggatagcaa gaccgactac cagggcttcc aaagcatgta caccttcgtg acttcccatt      840

tgccacccgg cttcaacgag tacgacttcg tgcccgagag cttcgaccgg gacaaaacca      900

tcgccctgat catgaacagt agtggcagta ccggattgcc caagggcgta gccctaccgc      960

accgcaccgc ttgtgtccga ttcagtcatg cccgcgaccc catcttcggc aaccagatca     1020

tccccgacac cgctatcctc agcgtggtgc catttcacca cggcttcggc atgttcacca     1080

cgctgggcta cttgatctgc ggctttcggg tcgtgctcat gtaccgcttc gaggaggagc     1140

tattcttgcg cagcttgcaa gactataaga ttcaatctgc cctgctggtg cccacactat     1200

ttagcttctt cgctaagagc actctcatcg acaagtacga cctaagcaac ttgcacgaga     1260

tcgccagcgg cggggcgccg ctcagcaagg aggtaggtga ggccgtggcc aaacgcttcc     1320

acctaccagg catccgccag ggctacggcc tgacagaaac aaccagcgcc attctgatca     1380

cccccgaagg ggacgacaag cctggcgcag taggcaaggt ggtgcccttc ttcgaggcta     1440

aggtggtgga cttggacacc ggtaagacac tgggtgtgaa ccagcgcggc gagctgtgcg     1500

tccgtggccc catgatcatg agcggctacg ttaacaaccc cgaggctaca aacgctctca     1560

tcgacaagga cggctggctg cacagcggcg acatcgccta ctgggacgag gacgagcact     1620

tcttcatcgt ggaccggctg aagagcctga tcaaatacaa gggctaccag gtagccccag     1680

ccgaactgga gagcatcctg ctgcaacacc ccaacatctt cgacgccggg gtcgccggcc     1740

tgcccgacga cgatgccggc gagctgcccg ccgcagtcgt cgtgctggaa cacggtaaaa     1800

ccatgaccga gaaggagatc gtggactatg tggccagcca ggttacaacc gccaagaagc     1860

tgcgcggtgg tgttgtgttc gtggacgagg tgcctaaagg actgaccggc aagttggacg     1920

cccgcaagat ccgcgagatt ctcattaagg ccaagaaggg cggcaagatc gccgtgtaat     1980

gaaagcttgg tctctacgag taatagacgc ccagttgaat tccttcgagc agacatgata     2040

agatacattg atgagtttgg acaaaccaca actagaatgc agtgaaaaaa atgctttatt     2100

tgtgaaattt gtgatgctat tgctttattt gtaaccatta taagctgcaa taaacaagtt     2160

aacaacaaca attgcattca ttttatgttt caggttcagg gggaggtgtg ggaggttttt     2220

taaagcaagt aaaacctcta caaatgtggt aaaatcgata aggatccgt                 2269


<210>  60
<211>  2425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Costruct ATF06-MP-002

<400>  60
gcgacgtaat acgactcact atagggcgaa ttggcggaag gccgtcaagg ccgcatgcat       60

aataaaatat ctttattttc attacatctg tgtgttggtt ttttgtgtgt gacgtgctga      120

tgatgcgtag ctagtagttg acgtgctgat gatgcgtagc tagtagttga cgtgctgatg      180

atgcgtagct agtagttgac gtgctgatga tgcgtagcta gtagttgacg tgctgatgat      240

gcgtagctag tagttgacgt gctgatgatg cgtagctagt agtgcagtta gcgtagctga      300

ggtaccgtcg acgatatcgg atccaggtct atataagcag agctcgttta gtgaaccgtc      360

agatcgccta gatacgccat ccacgctgtt ttgacctcca tagaagatcg ccaccatgga      420

agatgccaaa aacattaaga agggcccagc gccattctac ccactcgaag acgggaccgc      480

cggcgagcag ctgcacaaag ccatgaagcg ctacgccctg gtgcccggca ccatcgcctt      540

taccgacgca catatcgagg tggacattac ctacgccgag tacttcgaga tgagcgttcg      600

gctggcagaa gctatgaagc gctatgggct gaatacaaac catcggatcg tggtgtgcag      660

cgagaatagc ttgcagttct tcatgcccgt gttgggtgcc ctgttcatcg gtgtggctgt      720

ggccccagct aacgacatct acaacgagcg cgagctgctg aacagcatgg gcatcagcca      780

gcccaccgtc gtattcgtga gcaagaaagg gctgcaaaag atcctcaacg tgcaaaagaa      840

gctaccgatc atacaaaaga tcatcatcat ggatagcaag accgactacc agggcttcca      900

aagcatgtac accttcgtga cttcccattt gccacccggc ttcaacgagt acgacttcgt      960

gcccgagagc ttcgaccggg acaaaaccat cgccctgatc atgaacagta gtggcagtac     1020

cggattgccc aagggcgtag ccctaccgca ccgcaccgct tgtgtccgat tcagtcatgc     1080

ccgcgacccc atcttcggca accagatcat ccccgacacc gctatcctca gcgtggtgcc     1140

atttcaccac ggcttcggca tgttcaccac gctgggctac ttgatctgcg gctttcgggt     1200

cgtgctcatg taccgcttcg aggaggagct attcttgcgc agcttgcaag actataagat     1260

tcaatctgcc ctgctggtgc ccacactatt tagcttcttc gctaagagca ctctcatcga     1320

caagtacgac ctaagcaact tgcacgagat cgccagcggc ggggcgccgc tcagcaagga     1380

ggtaggtgag gccgtggcca aacgcttcca cctaccaggc atccgccagg gctacggcct     1440

gacagaaaca accagcgcca ttctgatcac ccccgaaggg gacgacaagc ctggcgcagt     1500

aggcaaggtg gtgcccttct tcgaggctaa ggtggtggac ttggacaccg gtaagacact     1560

gggtgtgaac cagcgcggcg agctgtgcgt ccgtggcccc atgatcatga gcggctacgt     1620

taacaacccc gaggctacaa acgctctcat cgacaaggac ggctggctgc acagcggcga     1680

catcgcctac tgggacgagg acgagcactt cttcatcgtg gaccggctga agagcctgat     1740

caaatacaag ggctaccagg tagccccagc cgaactggag agcatcctgc tgcaacaccc     1800

caacatcttc gacgccgggg tcgccggcct gcccgacgac gatgccggcg agctgcccgc     1860

cgcagtcgtc gtgctggaac acggtaaaac catgaccgag aaggagatcg tggactatgt     1920

ggccagccag gttacaaccg ccaagaagct gcgcggtggt gttgtgttcg tggacgaggt     1980

gcctaaagga ctgaccggca agttggacgc ccgcaagatc cgcgagattc tcattaaggc     2040

caagaagggc ggcaagatcg ccgtgtaatg aaagcttggt ctctacgagt aatagacgcc     2100

cagttgaatt ccttcgagca gacatgataa gatacattga tgagtttgga caaaccacaa     2160

ctagaatgca gtgaaaaaaa tgctttattt gtgaaatttg tgatgctatt gctttatttg     2220

taaccattat aagctgcaat aaacaagtta acaacaacaa ttgcattcat tttatgtttc     2280

aggttcaggg ggaggtgtgg gaggtttttt aaagcaagta aaacctctac aaatgtggta     2340

aaatcgataa ggatccgtct gggcctcatg ggccttccgc tcactgcccg ctttccagtc     2400

gggaaacctg tcgtgccagc tgcat                                           2425


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  61
gatgatgcgt agctagtagt                                                   20


