                         SEQUENCE LISTING

<110>  Inserm
 
<120>  METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF 
       OSTEOCLAST DISEASES

<130>  BIO17223-DAVIGNON

<160>  2     

<170>  PatentIn version 3.3

<210>  1
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Val Gly Glu Met Glu Thr Lys Glu Lys Pro Lys Pro Thr Pro Asp 
1               5                   10                  15      


Tyr Leu Met Gln Leu Met Asn Asp Lys Lys Leu Met Ser Ser Leu Pro 
            20                  25                  30          


Asn Phe Cys Gly Ile Phe Asn His Leu Glu Arg Leu Leu Asp Glu Glu 
        35                  40                  45              


Ile Ser Arg Val Arg Lys Asp Met Tyr Asn Asp Thr Leu Asn Gly Ser 
    50                  55                  60                  


Thr Glu Lys Arg Ser Ala Glu Leu Pro Asp Ala Val Gly Pro Ile Val 
65                  70                  75                  80  


Gln Leu Gln Glu Lys Leu Tyr Val Pro Val Lys Glu Tyr Pro Asp Phe 
                85                  90                  95      


Asn Phe Val Gly Arg Ile Leu Gly Pro Arg Gly Leu Thr Ala Lys Gln 
            100                 105                 110         


Leu Glu Ala Glu Thr Gly Cys Lys Ile Met Val Arg Gly Lys Gly Ser 
        115                 120                 125             


Met Arg Asp Lys Lys Lys Glu Glu Gln Asn Arg Gly Lys Pro Asn Trp 
    130                 135                 140                 


Glu His Leu Asn Glu Asp Leu His Val Leu Ile Thr Val Glu Asp Ala 
145                 150                 155                 160 


Gln Asn Arg Ala Glu Ile Lys Leu Lys Arg Ala Val Glu Glu Val Lys 
                165                 170                 175     


Lys Leu Leu Val Pro Ala Ala Glu Gly Glu Asp Ser Leu Lys Lys Met 
            180                 185                 190         


Gln Leu Met Glu Leu Ala Ile Leu Asn Gly Thr Tyr Arg Asp Ala Asn 
        195                 200                 205             


Ile Lys Ser Pro Thr Ala Gln Ala Ala Pro Arg Ile Ile Thr Gly Pro 
    210                 215                 220                 


Ala Pro Val Leu Pro Pro Ala Ala Leu Arg Thr Pro Thr Pro Ala Gly 
225                 230                 235                 240 


Pro Thr Ile Met Pro Leu Ile Arg Gln Ile Gln Thr Ala Val Met Pro 
                245                 250                 255     


Asn Gly Thr Pro His Pro Thr Ala Ala Ile Val Pro Pro Gly Pro Glu 
            260                 265                 270         


Ala Gly Leu Ile Tyr Thr Pro Tyr Glu Tyr Pro Tyr Thr Leu Ala Pro 
        275                 280                 285             


Ala Thr Ser Ile Leu Glu Tyr Pro Ile Glu Pro Ser Gly Val Leu Gly 
    290                 295                 300                 


Ala Val Ala Thr Lys Val Arg Arg His Asp Met Arg Val His Pro Tyr 
305                 310                 315                 320 


Gln Arg Ile Val Thr Ala Asp Arg Ala Ala Thr Gly Asn 
                325                 330             


<210>  2
<211>  9455
<212>  DNA
<213>  Homo sapiens

<400>  2
tgaactgagg cgaactccgc cgccaagtga gtgaggagga ggaggaggag aaggaggagg     60

aggaagagga ggagcgcagt cggagcgcgg cggcagcggc agaggcgccg cggcggggac    120

cagcccagag agaccccccg agcccgcggc acaggcggcg gcggcgctga gcgggctcga    180

ccagccgagc gagcggcggc cccggctcct cctcgtccgg cgccagcagc ccgcgccccg    240

cgcccgcact cggccagccg agacccgcct cccgcccgcc cgccggcctc gtgagggacg    300

cgccgagccg ggcggccgag agcggcggcg gctgggagcg cgtcgggccc gggcggaaag    360

tgcctgcggg gggcgggcga gcgcgcggtg ccggccgccc cggggctcgg cgcgggagcc    420

agagcgggag ccggcgcgga gcgggacgcc gggtcccgag cggcccgcgg ccggggctcg    480

cccccgcccc tccctcctct ccggcggcgg cggcggcggc ggcgggcgga gtgagctgcg    540

gagcctggaa tatggtcggg gaaatggaaa cgaaggagaa gccgaagccc accccagatt    600

acctgatgca gctgatgaac gacaagaagc tcatgagcag cctgcccaac ttctgcggga    660

tcttcaacca cctcgagcgg ctgctggacg aagaaattag cagagtacgg aaagacatgt    720

acaatgacac attaaatggc agtacagaga aaaggagtgc agaattgcct gatgctgtgg    780

gacctattgt tcagttacaa gagaaacttt atgtgcctgt aaaagaatac ccagatttta    840

attttgttgg gagaatcctt ggacctagag gacttacagc caaacaactt gaagcagaaa    900

ccggatgtaa aatcatggtc cgaggcaaag gctcaatgag ggataaaaaa aaggaggagc    960

aaaatagagg caagcccaat tgggagcatc taaatgaaga tttacatgta ctaatcactg   1020

tggaagatgc tcagaacaga gcagaaatca aattgaagag agcagttgaa gaagtgaaga   1080

aattattggt acctgcagca gaaggagaag acagcctgaa gaagatgcag ctgatggagc   1140

ttgcgattct gaatggcacc tacagagatg ccaacattaa atcaccaaca gcccaggctg   1200

ctccaaggat cattactggg cctgcgccgg ttctcccacc agctgccctg cgtactccta   1260

cgccagctgg ccctaccata atgcctttga tcagacaaat acagaccgct gtcatgccaa   1320

acggaactcc tcacccaact gctgcaatag ttcctccagg gcccgaagct ggtttaatct   1380

atacacccta tgagtacccc tacacattgg caccagctac atcaatcctt gagtatccta   1440

ttgaacctag tggtgtatta ggtgcggtgg ctactaaagt tcgaaggcac gatatgcgtg   1500

tccatcctta ccaaaggatt gtgaccgcag accgagccgc caccggcaac taacctatga   1560

ccttctgacc tctgaactct tcacccaatg atgacctgac catgcctgcc tgctgatcag   1620

ttaactggta atcgcctttg cttgcctgtc gtcagtgcag cgagctgagg cacttgtccg   1680

ttcgtcttac catctaacca aacaaaagac aaagaaattg ttgtcctcca actcagcttt   1740

tttttttttt ttttcctgtt tgggtgaaag tggttctaga aactgcactg aatagtagta   1800

aagcaataag gcccaattca tcccacagca ctgatcatct tttaatatcc caccctaagc   1860

gaacggtaag aaggcctctc ttaagaaggg gagacagatg gtccttaact actcaatgac   1920

agaggcagtt actgtgagag acttctagga atctttttct tctcatagcg aagtcaaagc   1980

tctctctgaa tgtactgtgt gatgatgcat catgcatgaa ccttcggtca gggatatcat   2040

tggtgaagtg atttcaaaaa gtattcaaaa tttgatatgc tgtttagtca ctacagtgcc   2100

ctcaaagggc agaagttgca gcctttttta tattgcctgc caaaatttga agtattagaa   2160

gaaagtgtgc catgagagaa aaacttaagg agttttgaaa agtaatgcaa ataacaaaac   2220

tgcaacacta tttttaaaaa gataaatatc tgagttaaaa ttactgaatc tttattttac   2280

acctaaaaaa atatgagaac aaggtacatg cattatgtgt cacattactg ggcaaactgt   2340

tcaagtattt ttttttaaac ctccctgtat agaaaaaaat cattaaggat gtaaaagcca   2400

tgcttgccta tttgctgtat acatgtaatg aaattgtaga taaagtgtag tgcattgaaa   2460

caaatgaaca aaaagtagat acttttacta tacaagggtg ctggtgcaga aaaaaatata   2520

tatatttttg gaaatgtagc attttatact ttcaagtgtt ataaaaaaaa agaaaaagaa   2580

caaagaaacc ctttatttca ttaaatgatt ttttctggtg gttgtcaaga aacaaaagac   2640

caaaagagcc tttttgtctt tcttttttat tttttaagta ttggaataag tctaaagaaa   2700

agaaagtgcc ttattttcct tcatggtcat tcagtcaagt gtctcataaa gatcagctcc   2760

tccctcagaa tacaagttaa tgcatgttac tcagtcgccc agtatgtgaa agaagatatg   2820

agggagacaa atgagttgat agtttgaatt ataggatttt tgccacgtta ccttgatgca   2880

aatttgccaa atctgatact gtgaaaagat ttgataactt ttctaatgcc tgactagtaa   2940

gttttaaaac atcattcttt aaaagaatag tttaatactt ttggttattc caatcttcaa   3000

tgttaaccca aaggattctg agataaaaat tatgtgtcat ctaaacttca gtttacagac   3060

aaaattagag ctttgtttta tttggagaag ggggatgcat tcatttgatt ttgttttttg   3120

tttttaatta attgaatata ataggatacc tagcaaatgt tttcacaaaa gtgaatcttt   3180

gtgattttca ttctagaaaa caatgtttta aatcacccaa atttaatcac atgtctttat   3240

atcataccag ataactggtg tagtgtatcc ttttactgtt tcaataacct ctgcctcccc   3300

caccccttaa ctttaaaaga atgtgaaaaa ctagcatcat agtgcatata aatactcaac   3360

cacatttcag cttaagcttc taatttctca agaagttgaa acagttagtt atgtagttga   3420

agcaatttgt gtgcaaagcc tacatctaaa cacttgagtg aataatcatt aactgctcag   3480

taccagacgt ggcaaatctc aagtgacagt ggaccccccc ccccgcccag cttatcaact   3540

cgtcccctct tccacacctt cccagcatca cagtcagagg tcagcaggaa gctgagtcat   3600

taccttcttg gtgacctccc ccaccatctt gtctcacttg gaaaccgttg tcagtttatt   3660

tactatgcaa tagacattca ttgttttgta tccagctagc tttggtttaa tatgccactg   3720

ctttgtcttt ctgttacaca tacagttttg atttatttac aatatatgct gtgccatttt   3780

gatttttata ttgtttggtt ggttgaataa atttgcgaca ctcaaacact tgaggtgata   3840

gttgttaaaa acaataccag tatttgatcc agtttcatct caactatgtt atacctggac   3900

attttagatg tttatcaaag gtcttttatg gggaagaaag taaatgtatg aaataataaa   3960

tgtgtgacat ttatagggaa tgttggctct gaacaaactt ttgaaaactt ggttgacaaa   4020

attttggatc aactgaaaaa agcatgactt ttgaaatctc tgaatgcctt ggttctcagt   4080

attatcattc tttattgaat ttatttctta ttaaaatatg tagtttttaa gacttttttt   4140

ctgacagtat tatgtaattt tttagcgtgg gtagatggga gtgtcgcttg tatgttatcg   4200

tacagctgac atgtattttt gtctattctt tattatctta gtttcatgct atgtatgtac   4260

cataaccaac ctattgccta tgagaaacat gtaagataat gtatttacag ccattgttac   4320

aagtttataa tgtatttttc tatcttgttt tatatgtatg ttatataaca ttcaaaaaga   4380

atttttttct tgattgagaa aaggatacaa aatgcaaaat ccacaatttt gataactgaa   4440

aattgccaat tgttttgcag tactttatta tattgggtgt cttgtctttt ttgggctttt   4500

agttagctaa tgaatgaata cattagacac ttttgggttt tagttgggat tttacatagc   4560

ttgcatttta attctttggt tctttgctgt ttctattaac ccacagcatt attttaataa   4620

atgttataat accaacctac taactctgga ctttgtctgt ttattaacct ttatatgttt   4680

aattaaaata aacaaataaa gacaaaagaa tgtaaagtct tgagttactg gactaaccct   4740

gaagaacgtg accacagata acatagtgtg acttgttttt atgttgtttg tcagctgaca   4800

gttttgcaca ctactgttaa aatggctttg gttattctgg tcttttagct tgggggccgg   4860

ggcgggtgtg ggtgtaggtg cagtagagat gggaacaaag tagcctttgt ttgaggcatt   4920

cttctcttgc cacttgcctt tcagcatctg cattactaat tccacacctt atttttcctt   4980

ctccaaaata atcactgtct gctcacagca tcgagtaaaa agatacattg tcatggtata   5040

tacctggaga aaccagtttg attctttgtt gaaccatttc ttttaatttc tgtaaataag   5100

taattttatg gtcacattgt aaagcagaga aactgttgat attttacctt tatttagatt   5160

tttgttttaa cttgaccttt ttcctttgga aagcgttgaa cttgtttagc taactactcc   5220

tattagggga gcttaacttg ggtaaagtca aaggcccact ggctgtttct catggtggcc   5280

tgaagccccg ctgctttcca gtgaggaaaa gaaccctcag cacgttactg agctttcctc   5340

aggtattttt ttctctgtca cctactttac aaatacagtc agactaaaac attaaacaag   5400

aagtttaagg gggaataaca ttgggatttg aaaagttgta tgtgattaat ttcttgcatg   5460

caaatcaatt taagatttct taaatatctt catgcttttc ttggctggaa cttgggtaaa   5520

ttaacctgta attatgaatt atttagttta actcaaggtg catttttatt tcacagattg   5580

atacttgctt ttttctgtga aacagttctc ctagatacca aaatcctcag gatgaatttt   5640

tgcatttgta aataacaatt tatctttgta aattacattt tatttattta gagttctaaa   5700

attgagggct gaaatgaatg acatgtaata gaagacaaaa ctgtaccaat acgctgttaa   5760

ccaatcagac tgtccaggta ttctcatttc ataaatatgt atacacacat ataaatacac   5820

agagtagtgt tagctgatgt gagtgataac agcgaatcac cattgagatg gtcatttgga   5880

tcatgtaaac aaaccgtgtc atgtctctga tgggagcggt gggtagtgta ctgttaggtg   5940

gacaggtctt ttaacatgct actatttgta aaagtttccg ttgccataac agttcatgta   6000

gtagtctgtg aaaattcgaa gctgtctgtc aagctgctaa tatacaagtt gtcatggtac   6060

catgtaactt aaattgatga atttctatgc aatttactat tctctgaagc ctatgaatgc   6120

agcctcatct cattttcagt taagggtact ttatgtataa ttatgtcatt gctgcctttt   6180

atgtaggaaa tgtaaaaaag ttttaaaagg cgaaaataac attacagatt tcatttttat   6240

acaggttaca atattaaaca tgaaactacc aaattccaag aatagtaaaa ttctagagtc   6300

agttgattga ttgaaactat ttgacaaaac agttgaaagc tgagctttca gtcaagaagt   6360

tggtgaaatt aatgtcctta aacttttcct ttaggcaaaa tgtcagggaa aacttaacat   6420

gaaagtagtt actcccatac gcaccagtgc agtagctcca ggtgtaagag gtcacgaagg   6480

caccctgccc ataaaaccag gatgtgcata cgtacacaca atcggtgtct ggttatggtt   6540

ttctaaacac tacataagga tctgaatttt ttagtgtgcc aaaagcaaac gataggttta   6600

aatgaaattg ctcactacca aatcaagact cttcatatat atacgtgtgt gtatatatat   6660

atgtcataac actttcacgt gtgacagcct aaggtttctt tagttttagg atggggtggg   6720

gtgggagtgg ttttgcatgt ttgaccagga tgtgatgcct gtctttattc cttgataaga   6780

agtagctgtt acagcatttc aagcaaatta ttttaggtag aatagaactt actgccaaat   6840

gattatttat ttagcaaaaa ttattctcca acttttcgaa ttcacaattt ttctaagtgc   6900

atagagtagt tttttacatt gtcacgaatt ccttaatacc tttatttaaa atggaaaaaa   6960

tatggacaat attttagaaa tatgtgctac acatctaatt ttatctgtag tttaagtgat   7020

ctaaattgag atgcctttga tatgaagaga tttaccaaca ttatatgcac tcgtgccttc   7080

aatgtggaat caaactggtt aacctcagca cagtcctctc gtttctgtgt ttctgctgca   7140

ctaattgcca gggggtgggg gagaaggcga atgaattaat tcatagtaga aggaggcgat   7200

aggtgcagca aagggcagcc acagtgttga ttccacatta taatgttgtt gcctcttctt   7260

ggcaaaagac accacattgt gggaagatct cagcttccag ggtaaaagtt aatttataac   7320

ttaaaagtgc tattaagttt ttattaccaa atatatcttt tatggtttat attgtagtgg   7380

tatgtatgaa acatttaaaa ttttactgtg gaaattgtgt atatatatat atatagtcga   7440

aataggtgtt cacaggtcac atgtgaacgg agaactgcat gaccgtacat gaaatgcaat   7500

aaaccaactg gaaaaagtgc atgtgcttca tcctctcaag ccaactgcag ctggaaagtg   7560

ctgcttatcc tccaccccca gaaaatgcat gtatcaatat gagaataaag aacgcacact   7620

ttcaatttta ttgaggcttt caacactatt taaaagaaaa tgtaagaatt tgacattctg   7680

gagttattat aacattagaa aatgagcata acattcactc tgattttagc cattaaggga   7740

gattagtaaa cagactgcta cagtgttcca tagttggact gtgcatccaa aacatttttt   7800

tatctttaat aaatggtaca gtttttatgt agttttcgaa tgtaagaaga aaggaatgct   7860

gaccaaaact tgatttcatc agcttcatga aaaggactag tgtcattaac ctgttgaaca   7920

gaattggttt attaaaaaaa tcatttccag tagtgtgaaa cctttacgag tctttaacat   7980

ctaaatgtta tgactccttg taccttaagt tttccagtct ttcttattta tatcatctcc   8040

aagtacctct ggctcctttc ctcttgctca ccggaacctt agttttcctc aacagaatgc   8100

tttgttaaag tagcccacag ttgcaggatc catagcaccg tcgtgcagac tagcagccca   8160

aaggtgtgtt tggtttggct tatacggtgt tttgcttttt aaactacttg ccataattta   8220

aaagtggcaa cactagactt aaaaaaaaaa aagtctgatt gcccatatta gatttttttt   8280

ttaattcttc acaaaatctg ctcttcctga aagatcaaag tgtctagaaa gcccaaacat   8340

gtattcttaa catagtaggc accagctgaa actgagtaat taaacggtcc cctgaagcca   8400

agtattccct ggttagtcgc caccccacca ctccttcctg tctctagtgt cacacttggg   8460

ctgttgattt tcttactctt ctcttgcttt aatccttccc cccggctctc tggctcctgt   8520

ggatatctgt gcttgtttcc tggtccagga tggtgatctg actttcaaac cagcttctca   8580

aaaggggtga cataaaatca gttttgatgt ttttcctcct gaaaaatcag atgaatattt   8640

tagtcactgt tactcatgca cattgtgttc ttatgtttac agaagtgctt aagtgaatgg   8700

aagcactaga catttggatt tccttcctaa cgtaattttt aatgattacc ccttttatac   8760

agtaatttgt ggtctttaga aagcagttaa actaattgac catctaatag ttgtactata   8820

catatgtcta aaataatagt catggtaagt ttggcatcat atcttcccca aaaaatgttt   8880

attaaaatta gattattcca gtttaatgct attttgtgaa ctgtataccc tctgaaagcg   8940

cttattttta catgctacac aacagttcca attttaagga gtgtctccta aaattgggat   9000

gaaaatctac tgtagtctgt tttaaagtat gctatactat gttcattggt tacttaactg   9060

gatattaata taaaggttat tacaagaaaa atgatgaaga gcaaaaggag aagaaaatat   9120

ttgcaagtga atccacaatt cttgcagaac tatttgagtt gatactaaag attttatgtt   9180

cactccttta ccttagaact gtcaagcttg ggaatgagga aagtgccttg gctgtgcttg   9240

aaacctgaat tttagtgctt cccttattac attcattgtt ttcaatgatt gatttataaa   9300

attaagacat actggtagta caagttgaaa gttggtttga atacatttta attaaatgat   9360

aatatgttaa tatgcttttg ttcattgctt tctcactgag gtaaaacagc attaaaaagt   9420

tgtccagaat ttaaactgaa aaaaaaaaaa aaaaa                              9455


