                         SEQUENCE LISTING

<110>  ADAGENE INC.
 
<120>  DYNAMIC HUMAN HEAVY CHAIN ANTIBODY LIBRARIES

<130>  IP170327

<160>  274   

<170>  PatentIn version 3.3

<210>  1
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 1

<400>  1

Phe Thr Phe Thr Asp Tyr Gly Ile His Trp Val 
1               5                   10      


<210>  2
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 2

<400>  2

Phe Thr Phe Thr Gly Tyr Ala Ile His Trp Val 
1               5                   10      


<210>  3
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 3

<400>  3

Phe Thr Phe Thr Asn Tyr Gly Ile His Trp Val 
1               5                   10      


<210>  4
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 4

<400>  4

Tyr Thr Phe Ser Asp Tyr Ala Ile His Trp Val 
1               5                   10      


<210>  5
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 5

<400>  5

Tyr Thr Phe Ser Asp Tyr Gly Ile His Trp Val 
1               5                   10      


<210>  6
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 6

<400>  6

Tyr Thr Phe Ser Gly Tyr Ala Ile His Trp Val 
1               5                   10      


<210>  7
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 7

<400>  7

Tyr Thr Phe Ser Gly Tyr Gly Ile His Trp Val 
1               5                   10      


<210>  8
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 8

<400>  8

Tyr Thr Phe Ser Asn Tyr Gly Ile His Trp Val 
1               5                   10      


<210>  9
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 9

<400>  9

Tyr Thr Phe Ser Ser Tyr Gly Ile His Trp Val 
1               5                   10      


<210>  10
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 10

<400>  10

Tyr Thr Phe Ser Gly Tyr Trp Ile His Trp Val 
1               5                   10      


<210>  11
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 11

<400>  11

Tyr Thr Phe Ser Asn Tyr Trp Ile His Trp Val 
1               5                   10      


<210>  12
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 12

<400>  12

Phe Thr Phe Ser Gly Tyr Trp Ile His Trp Val 
1               5                   10      


<210>  13
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 13

<400>  13

Phe Thr Phe Ser Asn Tyr Trp Ile His Trp Val 
1               5                   10      


<210>  14
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 14

<400>  14

Tyr Thr Phe Ser Asp Tyr Trp Ile His Trp Val 
1               5                   10      


<210>  15
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 15

<400>  15

Tyr Ser Ile Ser Ser Gly His His Trp Ala Trp Ile 
1               5                   10          


<210>  16
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 16

<400>  16

Tyr Ser Ile Ser Ser Gly His Tyr Trp Asn Trp Ile 
1               5                   10          


<210>  17
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 17

<400>  17

Tyr Ser Ile Ser Ser Gly His Tyr Trp Ser Trp Ile 
1               5                   10          


<210>  18
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 18

<400>  18

Tyr Ser Ile Ser Ser Gly His Tyr Trp Thr Trp Ile 
1               5                   10          


<210>  19
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 19

<400>  19

Tyr Ser Ile Ser Ser Gly Tyr His Trp Ala Trp Ile 
1               5                   10          


<210>  20
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 20

<400>  20

Tyr Ser Ile Ser Ser Gly Tyr His Trp Asp Trp Ile 
1               5                   10          


<210>  21
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 21

<400>  21

Tyr Ser Ile Ser Ser Gly Tyr His Trp Gly Trp Ile 
1               5                   10          


<210>  22
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 22

<400>  22

Tyr Ser Ile Ser Ser Gly Tyr His Trp Asn Trp Ile 
1               5                   10          


<210>  23
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 23

<400>  23

Tyr Ser Ile Ser Ser Gly Tyr His Trp Ser Trp Ile 
1               5                   10          


<210>  24
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 24

<400>  24

Tyr Ser Ile Ser Ser Gly His His Trp Asp Trp Ile 
1               5                   10          


<210>  25
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence

<400>  25

Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp Asp Trp Ile 
1               5                   10          


<210>  26
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 26

<400>  26

Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp Asn Trp Ile 
1               5                   10          


<210>  27
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 27

<400>  27

Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp Thr Trp Ile 
1               5                   10          


<210>  28
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 28

<400>  28

Tyr Ser Ile Thr Ser Gly His His Trp Ala Trp Ile 
1               5                   10          


<210>  29
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 29

<400>  29

Tyr Ser Ile Thr Ser Gly His His Trp Asp Trp Ile 
1               5                   10          


<210>  30
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 30

<400>  30

Tyr Ser Ile Thr Ser Gly His His Trp Gly Trp Ile 
1               5                   10          


<210>  31
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 31

<400>  31

Tyr Ser Ile Thr Ser Gly His His Trp Asn Trp Ile 
1               5                   10          


<210>  32
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 32

<400>  32

Tyr Ser Ile Thr Ser Gly His His Trp Ser Trp Ile 
1               5                   10          


<210>  33
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 33

<400>  33

Tyr Ser Ile Ser Ser Gly His His Trp Gly Trp Ile 
1               5                   10          


<210>  34
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 34

<400>  34

Tyr Ser Ile Thr Ser Gly His Tyr Trp Ala Trp Ile 
1               5                   10          


<210>  35
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 35

<400>  35

Tyr Ser Ile Thr Ser Gly His Tyr Trp Asp Trp Ile 
1               5                   10          


<210>  36
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 36

<400>  36

Tyr Ser Ile Thr Ser Gly His Tyr Trp Gly Trp Ile 
1               5                   10          


<210>  37
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 37

<400>  37

Tyr Ser Ile Thr Ser Gly His Tyr Trp Asn Trp Ile 
1               5                   10          


<210>  38
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 38

<400>  38

Tyr Ser Ile Thr Ser Gly His Tyr Trp Ser Trp Ile 
1               5                   10          


<210>  39
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 39

<400>  39

Tyr Ser Ile Thr Ser Gly Tyr His Trp Ala Trp Ile 
1               5                   10          


<210>  40
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 40

<400>  40

Tyr Ser Ile Thr Ser Gly Tyr His Trp Gly Trp Ile 
1               5                   10          


<210>  41
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 41

<400>  41

Tyr Ser Ile Ser Ser Gly His His Trp Asn Trp Ile 
1               5                   10          


<210>  42
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 42

<400>  42

Tyr Ser Ile Thr Ser Gly Tyr His Trp Asn Trp Ile 
1               5                   10          


<210>  43
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 43

<400>  43

Tyr Ser Ile Thr Ser Gly Tyr His Trp Ser Trp Ile 
1               5                   10          


<210>  44
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 44

<400>  44

Tyr Ser Ile Thr Ser Gly Tyr Tyr Trp Asp Trp Ile 
1               5                   10          


<210>  45
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 45

<400>  45

Tyr Ser Ile Ser Ser Gly His His Trp Thr Trp Ile 
1               5                   10          


<210>  46
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 46

<400>  46

Tyr Ser Ile Ser Ser Gly His Tyr Trp Asp Trp Ile 
1               5                   10          


<210>  47
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 47

<400>  47

Phe Ser Leu Ser Thr Ser Gly Val Ala Val Ser Trp Ile 
1               5                   10              


<210>  48
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 48

<400>  48

Phe Ser Leu Ser Thr Gly Gly Val Ala Val Gly Trp Ile 
1               5                   10              


<210>  49
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 49

<400>  49

Phe Ser Leu Ser Thr Gly Gly Val Ala Val Ser Trp Ile 
1               5                   10              


<210>  50
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 50

<400>  50

Phe Ser Leu Ser Thr Gly Gly Val Gly Val Ala Trp Ile 
1               5                   10              


<210>  51
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 51

<400>  51

Phe Ser Leu Ser Thr Gly Gly Val Gly Val Ser Trp Ile 
1               5                   10              


<210>  52
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 52

<400>  52

Phe Ser Leu Ser Thr Ser Gly Val Ala Val Ala Trp Ile 
1               5                   10              


<210>  53
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 1

<400>  53

Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser Leu 
1               5                   10                  15      


Lys Ser Arg Leu 
            20  


<210>  54
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 2

<400>  54

Leu Ala Leu Ile Asp Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser Leu 
1               5                   10                  15      


Lys Ser Arg Leu 
            20  


<210>  55
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 3

<400>  55

Leu Ala Leu Ile Asp Trp Asp Asp Asp Lys Arg Tyr Ser Thr Ser Leu 
1               5                   10                  15      


Lys Ser Arg Leu 
            20  


<210>  56
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 4

<400>  56

Leu Ala Leu Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Pro Ser Leu 
1               5                   10                  15      


Lys Ser Arg Leu 
            20  


<210>  57
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 5

<400>  57

Leu Ala Leu Ile Asp Trp Ala Asp Asp Lys Tyr Tyr Ser Pro Ser Leu 
1               5                   10                  15      


Lys Ser Arg Leu 
            20  


<210>  58
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 6

<400>  58

Leu Ala Leu Ile Asp Trp Ala Gly Asp Lys Ser Tyr Ser Thr Ser Leu 
1               5                   10                  15      


Lys Ser Arg Leu 
            20  


<210>  59
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 7

<400>  59

Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Pro Ser Leu 
1               5                   10                  15      


Lys Ser Arg Leu 
            20  


<210>  60
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 8

<400>  60

Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Thr Ser Leu 
1               5                   10                  15      


Lys Ser Arg Leu 
            20  


<210>  61
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 9

<400>  61

Leu Ala Arg Ile Asp Trp Asp Gly Asp Lys Tyr Tyr Ser Thr Ser Leu 
1               5                   10                  15      


Lys Ser Arg Leu 
            20  


<210>  62
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 10

<400>  62

Ile Gly Asp Ile Tyr His Ser Gly Ser Thr Tyr Tyr Ser Pro Ser Leu 
1               5                   10                  15      


Lys Ser Arg Val 
            20  


<210>  63
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 11

<400>  63

Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Tyr Tyr Ser Pro Ser Leu 
1               5                   10                  15      


Lys Ser Arg Val 
            20  


<210>  64
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 12

<400>  64

Ile Gly Glu Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Ser Pro Ser Leu 
1               5                   10                  15      


Lys Ser Arg Val 
            20  


<210>  65
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 13

<400>  65

Ile Gly Ser Ile Tyr His Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu 
1               5                   10                  15      


Lys Ser Arg Val 
            20  


<210>  66
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 14

<400>  66

Ile Gly Glu Ile Tyr His Ser Gly Asn Thr Tyr Tyr Asn Pro Ser Leu 
1               5                   10                  15      


Lys Ser Arg Val 
            20  


<210>  67
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 15

<400>  67

Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
1               5                   10                  15      


Lys Ser Arg Val 
            20  


<210>  68
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 16

<400>  68

Ile Gly Glu Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
1               5                   10                  15      


Lys Ser Arg Val 
            20  


<210>  69
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 17

<400>  69

Ile Gly Asp Ile Tyr His Ser Gly Asn Thr Tyr Tyr Asn Pro Ser Leu 
1               5                   10                  15      


Lys Ser Arg Val 
            20  


<210>  70
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 18

<400>  70

Ile Gly Asp Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
1               5                   10                  15      


Lys Ser Arg Val 
            20  


<210>  71
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 19

<400>  71

Val Ser Ala Ile Ser Gly Tyr Gly Asp Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  72
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 20

<400>  72

Val Ser Ala Ile Ser Gly Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  73
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 21

<400>  73

Val Ser Ala Ile Ser Gly Tyr Gly Gly Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  74
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 22

<400>  74

Val Ser Gly Ile Ser Gly Ala Gly Asp Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  75
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 23

<400>  75

Val Ser Gly Ile Ser Gly Asp Gly Asp Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  76
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 24

<400>  76

Val Ser Gly Ile Ser Gly Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  77
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 25

<400>  77

Val Ser Gly Ile Ser Gly Tyr Gly Asp Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  78
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 26

<400>  78

Val Ser Gly Ile Ser Gly Tyr Gly Gly Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  79
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 27

<400>  79

Val Ser Val Ile Ser Gly Asp Gly Asp Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  80
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 28

<400>  80

Val Ser Val Ile Ser Gly Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  81
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 29

<400>  81

Val Ser Gly Ile Ser Gly Asp Gly Ser Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  82
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 30

<400>  82

Val Ser Gly Ile Ser Gly Tyr Gly Ser Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  83
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 31

<400>  83

Val Ser Val Ile Ser Gly Ser Gly Ser Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  84
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 32

<400>  84

Val Ser Val Ile Ser Gly Tyr Gly Ser Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  85
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 33

<400>  85

Val Ser Val Ile Ser Gly Tyr Gly Ser Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  86
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 34

<400>  86

Val Ser Ala Ile Ser Gly Tyr Gly Ser Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  87
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 35

<400>  87

Val Ser Ser Ile Ser Gly Tyr Gly Asp Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  88
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 36

<400>  88

Val Ser Ser Ile Ser Gly Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  89
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 37

<400>  89

Val Ser Ser Ile Ser Gly Tyr Gly Gly Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  90
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 38

<400>  90

Val Ser Tyr Ile Ser Gly Ala Gly Asp Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  91
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 39

<400>  91

Val Ser Ser Ile Ser Gly Ala Gly Asp Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  92
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 40

<400>  92

Val Ser Tyr Ile Ser Gly Ala Gly Gly Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  93
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 41

<400>  93

Val Ser Tyr Ile Ser Gly Asp Gly Asp Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  94
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 42

<400>  94

Val Ser Tyr Ile Ser Gly Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  95
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 43

<400>  95

Val Ser Tyr Ile Ser Gly Asp Gly Gly Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  96
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 44

<400>  96

Val Ser Tyr Ile Ser Gly Ser Gly Asp Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  97
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 45

<400>  97

Val Ser Ser Ile Ser Gly Ala Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  98
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 46

<400>  98

Val Ser Tyr Ile Ser Gly Tyr Gly Asp Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  99
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 47

<400>  99

Val Ser Tyr Ile Ser Gly Tyr Gly Gly Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  100
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 48

<400>  100

Val Ser Ser Ile Ser Gly Ala Gly Gly Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  101
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 49

<400>  101

Val Ser Ser Ile Ser Gly Asp Gly Asp Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  102
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 50

<400>  102

Val Ser Ser Ile Ser Gly Asp Gly Gly Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  103
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 51

<400>  103

Val Ser Ser Ile Ser Gly Ala Gly Ser Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  104
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 52

<400>  104

Val Ser Ser Ile Ser Gly Ala Gly Ser Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  105
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 53

<400>  105

Val Ser Ser Ile Ser Gly Asp Gly Ser Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  106
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 54

<400>  106

Val Ser Ser Ile Ser Gly Asp Gly Ser Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  107
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 55

<400>  107

Val Ser Ser Ile Ser Gly Tyr Gly Ser Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  108
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 56

<400>  108

Val Ser Ser Ile Ser Gly Tyr Gly Ser Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  109
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 57

<400>  109

Ile Gly Trp Ile Asn Pro Asn Arg Gly Asp Thr Lys Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  110
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 58

<400>  110

Ile Gly Trp Ile Asn Pro Asn Arg Gly Asp Thr Asn Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  111
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 59

<400>  111

Ile Gly Trp Ile Asn Pro Asn Arg Gly Gly Thr Lys Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  112
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 60

<400>  112

Ile Gly Trp Ile Asn Pro Asn Arg Gly Gly Thr Asn Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  113
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 61

<400>  113

Ile Gly Trp Ile Asn Pro Asn Arg Gly Ser Thr Lys Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  114
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 62

<400>  114

Ile Gly Trp Ile Asn Pro Asn Arg Gly Ser Thr Asn Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  115
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 63

<400>  115

Ile Gly Arg Ile Asn Pro Asn Phe Gly Asp Thr Asn Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  116
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 64

<400>  116

Ile Gly Trp Ile Asn Pro Asn Phe Gly Asp Thr Asn Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  117
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 65

<400>  117

Ile Gly Trp Ile Asn Pro Asn Phe Gly Ser Thr Lys Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  118
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 66

<400>  118

Ile Gly Trp Ile Asn Pro Asn Phe Gly Ser Thr Asn Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  119
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 67

<400>  119

Ile Gly Ile Ile Asn Pro Asn Arg Gly Asp Thr Lys Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  120
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 68

<400>  120

Ile Gly Ile Ile Asn Pro Asn Arg Gly Asp Thr Asn Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  121
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 69

<400>  121

Ile Gly Ile Ile Asn Pro Asn Phe Gly Asp Thr Asn Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  122
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 70

<400>  122

Ile Gly Trp Ile Ser Pro Ser Gly Gly Gly Thr Lys Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  123
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 71

<400>  123

Ile Gly Trp Ile Ser Pro Ser Gly Gly Gly Thr Asn Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  124
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 72

<400>  124

Ile Gly Trp Ile Ser Pro Ser Ser Gly Gly Thr Lys Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  125
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 73

<400>  125

Ile Gly Trp Ile Ser Pro Ser Ser Gly Gly Thr Asn Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  126
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 74

<400>  126

Ile Gly Trp Ile Tyr Pro Ser Gly Gly Gly Thr Lys Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  127
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 75

<400>  127

Ile Gly Trp Ile Tyr Pro Ser Gly Gly Gly Thr Asn Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  128
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 76

<400>  128

Ile Gly Trp Ile Ser Pro Ser Gly Gly Ser Thr Asn Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  129
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 77

<400>  129

Ile Gly Trp Ile Ser Pro Ser Ser Gly Ser Thr Lys Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  130
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 78

<400>  130

Ile Gly Trp Ile Ser Pro Ser Ser Gly Ser Thr Asn Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  131
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 79

<400>  131

Ile Gly Trp Ile Ser Pro Ser Gly Gly Ser Thr Lys Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  132
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 80

<400>  132

Ile Gly Ile Ile Tyr Pro Ser Gly Gly Gly Thr Asn Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  133
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 81

<400>  133

Ile Gly Ile Ile Ser Pro Ser Gly Gly Gly Thr Lys Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  134
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 82

<400>  134

Ile Gly Ile Ile Ser Pro Ser Gly Gly Gly Thr Asn Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  135
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 83

<400>  135

Ile Gly Ile Ile Tyr Pro Ser Gly Gly Ser Thr Asn Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  136
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 84

<400>  136

Val Gly Arg Ile Lys Ser Lys Thr Asp Gly Tyr Thr Thr Glu Tyr Ala 
1               5                   10                  15      


Ala Pro Val Lys Gly Arg Phe 
            20              


<210>  137
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 53

<400>  137

Phe Thr Phe Ser Asp Tyr Ala Ile His Trp Val 
1               5                   10      


<210>  138
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 54

<400>  138

Phe Thr Phe Ser Asp Tyr Gly Ile His Trp Val 
1               5                   10      


<210>  139
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 55

<400>  139

Tyr Thr Phe Ser Asn Tyr Ala Ile His Trp Val 
1               5                   10      


<210>  140
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 56

<400>  140

Tyr Thr Phe Ser Ser Tyr Ala Ile His Trp Val 
1               5                   10      


<210>  141
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 57

<400>  141

Tyr Thr Phe Thr Asp Tyr Ala Ile His Trp Val 
1               5                   10      


<210>  142
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 58

<400>  142

Tyr Thr Phe Thr Asp Tyr Gly Ile His Trp Val 
1               5                   10      


<210>  143
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 60

<400>  143

Tyr Thr Phe Thr Asn Tyr Gly Ile His Trp Val 
1               5                   10      


<210>  144
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 61

<400>  144

Phe Thr Phe Ser Gly Tyr Gly Ile His Trp Val 
1               5                   10      


<210>  145
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 62

<400>  145

Phe Thr Phe Ser Asn Tyr Ala Ile His Trp Val 
1               5                   10      


<210>  146
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 63

<400>  146

Phe Thr Phe Ser Ser Tyr Gly Ile His Trp Val 
1               5                   10      


<210>  147
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 64

<400>  147

Phe Thr Phe Ser Asp Tyr Trp Ile His Trp Val 
1               5                   10      


<210>  148
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 65

<400>  148

Phe Thr Phe Thr Ser Tyr Trp Ile His Trp Val 
1               5                   10      


<210>  149
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 66

<400>  149

Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp Gly Trp Ile 
1               5                   10          


<210>  150
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 67

<400>  150

Tyr Ser Ile Thr Ser Gly Tyr Tyr Trp Asn Trp Ile 
1               5                   10          


<210>  151
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 68

<400>  151

Tyr Ser Ile Thr Ser Gly Tyr Tyr Trp Ser Trp Ile 
1               5                   10          


<210>  152
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 69

<400>  152

Tyr Ser Ile Ser Ser Gly His Tyr Trp Ala Trp Ile 
1               5                   10          


<210>  153
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 70

<400>  153

Tyr Ser Ile Ser Ser Gly His Tyr Trp Gly Trp Ile 
1               5                   10          


<210>  154
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 71

<400>  154

Phe Ser Leu Ser Thr Ser Gly Val Ala Val Gly Trp Ile 
1               5                   10              


<210>  155
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 72

<400>  155

Phe Ser Leu Ser Thr Ser Gly Val Gly Val Ala Trp Ile 
1               5                   10              


<210>  156
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 73

<400>  156

Phe Ser Leu Ser Thr Ser Gly Val Gly Val Gly Trp Ile 
1               5                   10              


<210>  157
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 74

<400>  157

Phe Ser Leu Ser Thr Gly Gly Val Gly Val Gly Trp Ile 
1               5                   10              


<210>  158
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 85

<400>  158

Val Ser Ala Ile Ser Gly Ser Gly Ser Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  159
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 86

<400>  159

Val Ser Ser Ile Ser Gly Ser Gly Asp Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  160
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 87

<400>  160

Val Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  161
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 88

<400>  161

Val Ser Ser Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  162
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 89

<400>  162

Val Ser Ser Ile Ser Gly Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  163
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H2 sequence 90

<400>  163

Val Ser Ser Ile Ser Gly Ser Gly Ser Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  164
<211>  26
<212>  PRT
<213>  artificial sequence

<220>
<223>  Framework FW-H1 sequence

<400>  164

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            20                  25      


<210>  165
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Framework FW-H2 sequence

<400>  165

Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
1               5                   10  


<210>  166
<211>  29
<212>  PRT
<213>  artificial sequence

<220>
<223>  Framework FW-H3 sequence

<400>  166

Thr Ile Ser Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Leu 
1               5                   10                  15      


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
            20                  25                  


<210>  167
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Framework FW-H4 sequence

<400>  167

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  168
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hit ID 4029 - VH

<400>  168

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr His Trp Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Tyr Ile Ser Gly Ala Gly Asp Thr Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Tyr Gly Asp Tyr Tyr Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  169
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  HIT ID 4029 - VL

<400>  169

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Asp Phe Tyr 
            20                  25                  30          


Gly Ile Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
                85                  90                  95      


Arg Thr Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  170
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Designed HVR-H1 sequence 59

<400>  170

Tyr Thr Phe Thr Asn Tyr Ala Ile His Trp Val 
1               5                   10      


<210>  171
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hit ID 7097 - VH

<400>  171

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


His His Trp Asp Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Tyr Ile Ser Gly Ala Gly Asp Thr Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Gly Ser Asp Ala Val Leu Gly Asp Trp Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  172
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  HIT ID 7097 - VL

<400>  172

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  173
<211>  124
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hit ID 5906 - VH

<400>  173

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr His Trp Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Tyr Ile Ser Gly Asp Gly Asp Thr Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Leu Gly Gly Tyr Tyr Gly Trp Gly Arg Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  174
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  HIT ID 5906 - VL

<400>  174

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  175
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hit ID 7040 - VH

<400>  175

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Trp Ile Ser Pro Ser Gly Gly Ser Thr Asn Tyr Ala Gln Lys 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Leu Thr Ala Gly Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  176
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  HIT ID 7040 - VL

<400>  176

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  177
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hit ID 5924 - VH

<400>  177

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr His Trp Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ile Ile Ser Pro Ser Ser Gly Ser Thr Lys Tyr Ala Gln Lys 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Ala Gly Val His Tyr Ala Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  178
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  HIT ID 5924 - VL

<400>  178

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  179
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hit ID 4034 - VH

<400>  179

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


His Tyr Trp Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Ser Ile Ser Gly Tyr Gly Ser Thr Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Arg Tyr Tyr Gly Ser Thr Asp Tyr Ala Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  180
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  HIT ID 4034 - VL

<400>  180

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Arg Val Ser His Val 
            20                  25                  30          


Phe Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Phe Cys Leu Gln Gly Thr His Phe Pro Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105         


<210>  181
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hit ID 6010 - VH

<400>  181

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


His Tyr Trp Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Trp Ile Asn Pro Asn Arg Gly Asp Thr Asn Tyr Ala Gln Lys 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Tyr Tyr Gly Asp Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  182
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  HIT ID 6010 - VL

<400>  182

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  183
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hit ID 7183 - VH

<400>  183

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


His Tyr Trp Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Ser Ile Ser Gly Tyr Gly Asp Thr Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Gly Ser Asp Thr Val Leu Gly Asp Trp Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  184
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  HIT ID 7183 - VL

<400>  184

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  185
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hit ID 4036 - VH

<400>  185

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Tyr Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Arg Tyr Gly Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  186
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  HIT ID 4036 - VL

<400>  186

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Asp Phe Tyr 
            20                  25                  30          


Gly Lys Ser Phe Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr 
                85                  90                  95      


Arg Ile Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  187
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hit ID 5115 - VH

<400>  187

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


His Tyr Trp Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Tyr Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Tyr Tyr Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  188
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  HIT ID 5115 - VL

<400>  188

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Thr Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  189
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hit ID 5404 - VH

<400>  189

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr His Trp Ala Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Tyr Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Pro Tyr Tyr Tyr Gly Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  190
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  HIT ID 5404 - VL

<400>  190

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Arg Val Gly Ser Val 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Thr His Asp Pro Val Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105         


<210>  191
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hit ID 3757 - VH

<400>  191

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Ser Pro Ser Gly Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Ser Tyr Tyr Gly Val Gly Asp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  192
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  HIT ID 3757 - VL

<400>  192

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  193
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hit ID 5103 - VH

<400>  193

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Ser Pro Ser Gly Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Ser Tyr Tyr Gly Val Gly Asp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  194
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  HIT ID 5103 - VL

<400>  194

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  195
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hit ID 4027 - VH

<400>  195

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


His His Trp Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Trp Ile Ser Pro Ser Ser Gly Gly Thr Lys Tyr Ala Gln Lys 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Phe Asp Gly Phe His Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  196
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  HIT ID 4027 - VL

<400>  196

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Phe Tyr 
            20                  25                  30          


Gly Ile Ser Phe Leu Pro Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
                85                  90                  95      


Ser Trp Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  197
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH in FIG. 1B

<400>  197

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ala Gly Asp Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Asp Tyr Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  198
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Formula (I)


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  198

Xaa Thr Phe Xaa Xaa Tyr Xaa Ile His Trp Val 
1               5                   10      


<210>  199
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Formula (II)


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<400>  199

Tyr Ser Ile Xaa Ser Gly Xaa Xaa Trp Xaa Trp Ile 
1               5                   10          


<210>  200
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  Formula (III)


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<400>  200

Phe Ser Leu Ser Thr Xaa Gly Val Xaa Val Xaa Trp Ile 
1               5                   10              


<210>  201
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Formula (IV)


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<400>  201

Leu Ala Xaa Ile Xaa Trp Xaa Xaa Asp Lys Xaa Tyr Ser Xaa Ser Leu 
1               5                   10                  15      


Lys Ser Arg Leu 
            20  


<210>  202
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Formula (V)


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  202

Ile Gly Xaa Ile Xaa Xaa Ser Gly Ser Thr Tyr Tyr Ser Pro Ser Leu 
1               5                   10                  15      


Lys Ser Arg Val 
            20  


<210>  203
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Formula (VI)


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<400>  203

Ile Gly Xaa Ile Tyr Xaa Ser Gly Xaa Thr Xaa Tyr Asn Pro Ser Leu 
1               5                   10                  15      


Lys Ser Arg Val 
            20  


<210>  204
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Formula (VII)


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  Xaa can be any naturally occurring amino acid

<400>  204

Val Ser Xaa Ile Ser Gly Xaa Gly Xaa Xaa Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  205
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Formula (VIII)


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  205

Ile Gly Xaa Ile Asn Pro Asn Xaa Gly Xaa Thr Xaa Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  206
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Formula (IX)


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  206

Ile Gly Xaa Ile Xaa Pro Ser Xaa Gly Xaa Thr Xaa Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Val 
            20      


<210>  207
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  Formula (X)


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  207

Val Gly Arg Ile Xaa Ser Lys Xaa Xaa Gly Xaa Thr Thr Xaa Tyr Ala 
1               5                   10                  15      


Ala Xaa Val Lys Gly Arg Phe 
            20              


<210>  208
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Formula (XI)


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  208

Ile Gly Xaa Ile Xaa Xaa Ser Gly Ser Thr Tyr Tyr Ser Pro Ser Leu 
1               5                   10                  15      


Lys Ser Arg Val 
            20  


<210>  209
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Formula (XII)


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<400>  209

Ile Gly Xaa Ile Tyr Xaa Ser Gly Xaa Thr Xaa Tyr Asn Pro Ser Leu 
1               5                   10                  15      


Lys Ser Arg Val 
            20  


<210>  210
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  Formula (XIII)


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  210

Val Gly Arg Ile Xaa Ser Lys Xaa Xaa Gly Xaa Thr Thr Glu Tyr Ala 
1               5                   10                  15      


Ala Xaa Val Lys Gly Arg Phe 
            20              


<210>  211
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer F_1999

<400>  211
cgtttgtcct gtgcagcttc cgg                                             23


<210>  212
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer R_1999

<400>  212
cgaggccctt acccggggcc tgacg                                           25


<210>  213
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer F_2003

<400>  213
ccgggtaagg gcctcgagtg g                                               21


<210>  214
<211>  33
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer R_2003

<400>  214
gagcacgtcc gttcgaattg tcgcgactta tag                                  33


<210>  215
<211>  45
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer S1089

<400>  215
acaactgaac agcttaagag ctgaggacac tgccgtctat tattg                     45


<210>  216
<211>  32
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer S1090

<400>  216
gaggagacgg tgactagtgt tccttgaccc ca                                   32


<210>  217
<211>  34
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer F_2898

<400>  217
tacttatgta ggcgatcggg tcaccatcac ctgc                                 34


<210>  218
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer R_2898

<400>  218
cggagctttt cctggtttct gttgatac                                        28


<210>  219
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer F_2013

<400>  219
gaaaccagga aaagctccga ag                                              22


<210>  220
<211>  29
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer R_2013

<400>  220
cgtcccggaa ccggatccag agaagcgag                                       29


<210>  221
<211>  35
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer F2929

<400>  221
accatcagca gtctgcagcc ggaagacttc gcaac                                35


<210>  222
<211>  27
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer R2929

<400>  222
gatctccacc ttggtaccct gtccgaa                                         27


<210>  223
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 1

<400>  223

Ala Arg Asp Leu Gly Gly Tyr Tyr Gly Trp Gly Arg Tyr Phe Asp Tyr 
1               5                   10                  15      


<210>  224
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 2

<400>  224

Ala Arg Asp Leu Thr Ala Gly Gly Phe Asp Tyr 
1               5                   10      


<210>  225
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 3

<400>  225

Ala Arg Asp Pro Gly Val Gly Gly Phe Asp Val 
1               5                   10      


<210>  226
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 4

<400>  226

Ala Arg Asp Pro Gly Tyr Thr Trp Tyr Phe Asp Val 
1               5                   10          


<210>  227
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 5

<400>  227

Ala Arg Asp Tyr Gly Asp Tyr Tyr Gly Phe Asp Tyr 
1               5                   10          


<210>  228
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 6

<400>  228

Ala Arg Asp Tyr Gly Tyr Thr Trp Tyr Phe Asp Val 
1               5                   10          


<210>  229
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 7

<400>  229

Ala Arg Asp Tyr Tyr Gly Asp Phe Asp Tyr 
1               5                   10  


<210>  230
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 8

<400>  230

Ala Arg Glu Gly Ser Asp Ala Val Leu Gly Asp Trp Phe Ala Tyr 
1               5                   10                  15  


<210>  231
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 9

<400>  231

Ala Arg Glu Gly Ser Asp Thr Val Leu Gly Asp Trp Phe Ala Tyr 
1               5                   10                  15  


<210>  232
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 10

<400>  232

Ala Arg Glu Arg Tyr Gly Ser Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210>  233
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 11

<400>  233

Ala Arg Glu Arg Tyr Tyr Gly Ser Thr Asp Tyr Ala Phe Asp Tyr 
1               5                   10                  15  


<210>  234
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 12

<400>  234

Ala Arg Glu Ser Tyr Tyr Ala Phe Asp Tyr 
1               5                   10  


<210>  235
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 13

<400>  235

Ala Arg Gly Ala Gly Val His Tyr Ala Leu Asp Tyr 
1               5                   10          


<210>  236
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 14

<400>  236

Ala Arg Gly Phe Asp Gly Phe His Tyr 
1               5                   


<210>  237
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 15

<400>  237

Ala Arg Gly Phe Tyr Gly Gly Ala Leu Asp Val 
1               5                   10      


<210>  238
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 16

<400>  238

Ala Arg Gly Gly Gly Gly Tyr Tyr Phe Asp Val 
1               5                   10      


<210>  239
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 17

<400>  239

Ala Arg Gly Gly Gly Leu Gly Phe Asp Tyr 
1               5                   10  


<210>  240
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 18

<400>  240

Ala Arg Gly Gly Leu Gly Pro Phe Asp Ile 
1               5                   10  


<210>  241
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 19

<400>  241

Ala Arg Gly Gly Ser Asp Thr Val Ile Gly Asp Trp Phe Ala Tyr 
1               5                   10                  15  


<210>  242
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 20

<400>  242

Ala Arg Gly Gly Val Gly Pro Phe Asp Ile 
1               5                   10  


<210>  243
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 21

<400>  243

Ala Arg Gly Gly Tyr Gly Gly Tyr Leu Asp Val 
1               5                   10      


<210>  244
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 22

<400>  244

Ala Arg Gly Leu Ser Ser Gly Tyr Phe Asp Tyr 
1               5                   10      


<210>  245
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 23

<400>  245

Ala Arg Gly Ser Trp Tyr Phe Asp Val 
1               5                   


<210>  246
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 24

<400>  246

Ala Arg Gly Thr Arg Gly Leu Asp Tyr 
1               5                   


<210>  247
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 25

<400>  247

Ala Arg Gly Tyr Ser Asp Tyr Phe Asp Tyr 
1               5                   10  


<210>  248
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 26

<400>  248

Ala Arg Gly Tyr Tyr Tyr Gly Arg Ala Phe Asp Tyr 
1               5                   10          


<210>  249
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 27

<400>  249

Ala Arg His Ser Tyr Tyr Gly Val Gly Asp Phe Asp Tyr 
1               5                   10              


<210>  250
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 28

<400>  250

Ala Arg Leu Phe Glu Gly Phe Pro Tyr 
1               5                   


<210>  251
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 29

<400>  251

Ala Arg Leu Tyr Asp Tyr Phe Ala Tyr 
1               5                   


<210>  252
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 30

<400>  252

Ala Arg Ser Gly Tyr Tyr Ala Leu Asp Tyr 
1               5                   10  


<210>  253
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 31

<400>  253

Ala Arg Ser Pro Tyr Tyr Tyr Gly Val Phe Asp Tyr 
1               5                   10          


<210>  254
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 32

<400>  254

Ala Arg Ser Tyr Val Tyr Phe Asp Tyr 
1               5                   


<210>  255
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 33

<400>  255

Ala Arg Asp Gly Leu Gly Leu Arg Gly Val Tyr Tyr Tyr Tyr Tyr Gly 
1               5                   10                  15      


Leu Asp Val 
            


<210>  256
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-H3 sequence 34

<400>  256

Ala Arg Val Gly Glu Ser Gly Gly Ile Glu Ser Pro Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Gly Leu Asp Val 
            20  


<210>  257
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-L1 sequence 1

<400>  257

Arg Ala Ser Glu Ser Val Asp Phe Tyr Gly Ile Ser Phe Leu Pro 
1               5                   10                  15  


<210>  258
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-L1 sequence 2

<400>  258

Arg Ala Ser Gln Ser Val Asp Phe Tyr Gly Ile Ser Phe Leu Ala 
1               5                   10                  15  


<210>  259
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-L1 sequence 3

<400>  259

Arg Ala Ser Gln Ser Val Asp Phe Tyr Gly Lys Ser Phe Leu Asp 
1               5                   10                  15  


<210>  260
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-L1 sequence 4

<400>  260

Ser Ala Ser Ser Arg Val Gly Ser Val Tyr 
1               5                   10  


<210>  261
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-L1 sequence 5

<400>  261

Ser Ala Ser Ser Arg Val Ser His Val Phe 
1               5                   10  


<210>  262
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-L1 sequence 6

<400>  262

Arg Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  263
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-L1 sequence 7

<400>  263

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  264
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-L1 sequence 8

<400>  264

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  265
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-L3 sequence 1

<400>  265

Phe Cys Leu Gln Gly Thr His Phe Pro Trp Thr 
1               5                   10      


<210>  266
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-L3 sequence 2

<400>  266

Tyr Cys Gln Gln Ser Tyr Arg Thr Pro Phe Thr 
1               5                   10      


<210>  267
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-L3 sequence 3

<400>  267

Tyr Cys Gln Gln Ser Tyr Ser Trp Pro Trp Thr 
1               5                   10      


<210>  268
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-L3 sequence 4

<400>  268

Tyr Cys Gln Gln Tyr Thr His Asp Pro Val Thr 
1               5                   10      


<210>  269
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-L3 sequence 5

<400>  269

Tyr Cys Gln Gln Tyr Tyr Arg Ile Pro Pro Thr 
1               5                   10      


<210>  270
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-L3 sequence 6

<400>  270

Tyr Cys Gln His His Tyr Gly Thr Pro Leu Thr 
1               5                   10      


<210>  271
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-L3 sequence 7

<400>  271

Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   10      


<210>  272
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-L3 sequence 8

<400>  272

Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr 
1               5                   10      


<210>  273
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-L3 sequence 9

<400>  273

Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Leu Thr 
1               5                   10      


<210>  274
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HVR-L3 sequence 10

<400>  274

Tyr Cys Gln Gln Tyr Tyr Thr Thr Pro Leu Thr 
1               5                   10      


