                         SEQUENCE LISTING

<110>  CELDARA MEDICAL LLC
 
<120>  CELLULAR BASED THERAPIES TARGETING DISEASE-ASSOCIATED MOLECULAR 
       MEDIATORS OF FIBROTIC, INFLAMMATORY AND AUTOIMMUNE CONDITIONS

<130>  56867.1213

<140>  PCT/US2018/47101
<141>  2018-08-20

<150>  62/547,184
<151>  2017-08-18

<160>  884   

<170>  PatentIn version 3.5


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<210>  101
<211>  1456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CD206

<400>  101

Met Arg Leu Pro Leu Leu Leu Val Phe Ala Ser Val Ile Pro Gly Ala 
1               5                   10                  15      


Val Leu Leu Leu Asp Thr Arg Gln Phe Leu Ile Tyr Asn Glu Asp His 
            20                  25                  30          


Lys Arg Cys Val Asp Ala Val Ser Pro Ser Ala Val Gln Thr Ala Ala 
        35                  40                  45              


Cys Asn Gln Asp Ala Glu Ser Gln Lys Phe Arg Trp Val Ser Glu Ser 
    50                  55                  60                  


Gln Ile Met Ser Val Ala Phe Lys Leu Cys Leu Gly Val Pro Ser Lys 
65                  70                  75                  80  


Thr Asp Trp Val Ala Ile Thr Leu Tyr Ala Cys Asp Ser Lys Ser Glu 
                85                  90                  95      


Phe Gln Lys Trp Glu Cys Lys Asn Asp Thr Leu Leu Gly Ile Lys Gly 
            100                 105                 110         


Glu Asp Leu Phe Phe Asn Tyr Gly Asn Arg Gln Glu Lys Asn Ile Met 
        115                 120                 125             


Leu Tyr Lys Gly Ser Gly Leu Trp Ser Arg Trp Lys Ile Tyr Gly Thr 
    130                 135                 140                 


Thr Asp Asn Leu Cys Ser Arg Gly Tyr Glu Ala Met Tyr Thr Leu Leu 
145                 150                 155                 160 


Gly Asn Ala Asn Gly Ala Thr Cys Ala Phe Pro Phe Lys Phe Glu Asn 
                165                 170                 175     


Lys Trp Tyr Ala Asp Cys Thr Ser Ala Gly Arg Ser Asp Gly Trp Leu 
            180                 185                 190         


Trp Cys Gly Thr Thr Thr Asp Tyr Asp Thr Asp Lys Leu Phe Gly Tyr 
        195                 200                 205             


Cys Pro Leu Lys Phe Glu Gly Ser Glu Ser Leu Trp Asn Lys Asp Pro 
    210                 215                 220                 


Leu Thr Ser Val Ser Tyr Gln Ile Asn Ser Lys Ser Ala Leu Thr Trp 
225                 230                 235                 240 


His Gln Ala Arg Lys Ser Cys Gln Gln Gln Asn Ala Glu Leu Leu Ser 
                245                 250                 255     


Ile Thr Glu Ile His Glu Gln Thr Tyr Leu Thr Gly Leu Thr Ser Ser 
            260                 265                 270         


Leu Thr Ser Gly Leu Trp Ile Gly Leu Asn Ser Leu Ser Phe Asn Ser 
        275                 280                 285             


Gly Trp Gln Trp Ser Asp Arg Ser Pro Phe Arg Tyr Leu Asn Trp Leu 
    290                 295                 300                 


Pro Gly Ser Pro Ser Ala Glu Pro Gly Lys Ser Cys Val Ser Leu Asn 
305                 310                 315                 320 


Pro Gly Lys Asn Ala Lys Trp Glu Asn Leu Glu Cys Val Gln Lys Leu 
                325                 330                 335     


Gly Tyr Ile Cys Lys Lys Gly Asn Thr Thr Leu Asn Ser Phe Val Ile 
            340                 345                 350         


Pro Ser Glu Ser Asp Val Pro Thr His Cys Pro Ser Gln Trp Trp Pro 
        355                 360                 365             


Tyr Ala Gly His Cys Tyr Lys Ile His Arg Asp Glu Lys Lys Ile Gln 
    370                 375                 380                 


Arg Asp Ala Leu Thr Thr Cys Arg Lys Glu Gly Gly Asp Leu Thr Ser 
385                 390                 395                 400 


Ile His Thr Ile Glu Glu Leu Asp Phe Ile Ile Ser Gln Leu Gly Tyr 
                405                 410                 415     


Glu Pro Asn Asp Glu Leu Trp Ile Gly Leu Asn Asp Ile Lys Ile Gln 
            420                 425                 430         


Met Tyr Phe Glu Trp Ser Asp Gly Thr Pro Val Thr Phe Thr Lys Trp 
        435                 440                 445             


Leu Arg Gly Glu Pro Ser His Glu Asn Asn Arg Gln Glu Asp Cys Val 
    450                 455                 460                 


Val Met Lys Gly Lys Asp Gly Tyr Trp Ala Asp Arg Gly Cys Glu Trp 
465                 470                 475                 480 


Pro Leu Gly Tyr Ile Cys Lys Met Lys Ser Arg Ser Gln Gly Pro Glu 
                485                 490                 495     


Ile Val Glu Val Glu Lys Gly Cys Arg Lys Gly Trp Lys Lys His His 
            500                 505                 510         


Phe Tyr Cys Tyr Met Ile Gly His Thr Leu Ser Thr Phe Ala Glu Ala 
        515                 520                 525             


Asn Gln Thr Cys Asn Asn Glu Asn Ala Tyr Leu Thr Thr Ile Glu Asp 
    530                 535                 540                 


Arg Tyr Glu Gln Ala Phe Leu Thr Ser Phe Val Gly Leu Arg Pro Glu 
545                 550                 555                 560 


Lys Tyr Phe Trp Thr Gly Leu Ser Asp Ile Gln Thr Lys Gly Thr Phe 
                565                 570                 575     


Gln Trp Thr Ile Glu Glu Glu Val Arg Phe Thr His Trp Asn Ser Asp 
            580                 585                 590         


Met Pro Gly Arg Lys Pro Gly Cys Val Ala Met Arg Thr Gly Ile Ala 
        595                 600                 605             


Gly Gly Leu Trp Asp Val Leu Lys Cys Asp Glu Lys Ala Lys Phe Val 
    610                 615                 620                 


Cys Lys His Trp Ala Glu Gly Val Thr His Pro Pro Lys Pro Thr Thr 
625                 630                 635                 640 


Thr Pro Glu Pro Lys Cys Pro Glu Asp Trp Gly Ala Ser Ser Arg Thr 
                645                 650                 655     


Ser Leu Cys Phe Lys Leu Tyr Ala Lys Gly Lys His Glu Lys Lys Thr 
            660                 665                 670         


Trp Phe Glu Ser Arg Asp Phe Cys Arg Ala Leu Gly Gly Asp Leu Ala 
        675                 680                 685             


Ser Ile Asn Asn Lys Glu Glu Gln Gln Thr Ile Trp Arg Leu Ile Thr 
    690                 695                 700                 


Ala Ser Gly Ser Tyr His Lys Leu Phe Trp Leu Gly Leu Thr Tyr Gly 
705                 710                 715                 720 


Ser Pro Ser Glu Gly Phe Thr Trp Ser Asp Gly Ser Pro Val Ser Tyr 
                725                 730                 735     


Glu Asn Trp Ala Tyr Gly Glu Pro Asn Asn Tyr Gln Asn Val Glu Tyr 
            740                 745                 750         


Cys Gly Glu Leu Lys Gly Asp Pro Thr Met Ser Trp Asn Asp Ile Asn 
        755                 760                 765             


Cys Glu His Leu Asn Asn Trp Ile Cys Gln Ile Gln Lys Gly Gln Thr 
    770                 775                 780                 


Pro Lys Pro Glu Pro Thr Pro Ala Pro Gln Asp Asn Pro Pro Val Thr 
785                 790                 795                 800 


Glu Asp Gly Trp Val Ile Tyr Lys Asp Tyr Gln Tyr Tyr Phe Ser Lys 
                805                 810                 815     


Glu Lys Glu Thr Met Asp Asn Ala Arg Ala Phe Cys Lys Arg Asn Phe 
            820                 825                 830         


Gly Asp Leu Val Ser Ile Gln Ser Glu Ser Glu Lys Lys Phe Leu Trp 
        835                 840                 845             


Lys Tyr Val Asn Arg Asn Asp Ala Gln Ser Ala Tyr Phe Ile Gly Leu 
    850                 855                 860                 


Leu Ile Ser Leu Asp Lys Lys Phe Ala Trp Met Asp Gly Ser Lys Val 
865                 870                 875                 880 


Asp Tyr Val Ser Trp Ala Thr Gly Glu Pro Asn Phe Ala Asn Glu Asp 
                885                 890                 895     


Glu Asn Cys Val Thr Met Tyr Ser Asn Ser Gly Phe Trp Asn Asp Ile 
            900                 905                 910         


Asn Cys Gly Tyr Pro Asn Ala Phe Ile Cys Gln Arg His Asn Ser Ser 
        915                 920                 925             


Ile Asn Ala Thr Thr Val Met Pro Thr Met Pro Ser Val Pro Ser Gly 
    930                 935                 940                 


Cys Lys Glu Gly Trp Asn Phe Tyr Ser Asn Lys Cys Phe Lys Ile Phe 
945                 950                 955                 960 


Gly Phe Met Glu Glu Glu Arg Lys Asn Trp Gln Glu Ala Arg Lys Ala 
                965                 970                 975     


Cys Ile Gly Phe Gly Gly Asn Leu Val Ser Ile Gln Asn Glu Lys Glu 
            980                 985                 990         


Gln Ala Phe Leu Thr Tyr His Met  Lys Asp Ser Thr Phe  Ser Ala Trp 
        995                 1000                 1005             


Thr Gly  Leu Asn Asp Val Asn  Ser Glu His Thr Phe  Leu Trp Thr 
    1010                 1015                 1020             


Asp Gly  Arg Gly Val His Tyr  Thr Asn Trp Gly Lys  Gly Tyr Pro 
    1025                 1030                 1035             


Gly Gly  Arg Arg Ser Ser Leu  Ser Tyr Glu Asp Ala  Asp Cys Val 
    1040                 1045                 1050             


Val Ile  Ile Gly Gly Ala Ser  Asn Glu Ala Gly Lys  Trp Met Asp 
    1055                 1060                 1065             


Asp Thr  Cys Asp Ser Lys Arg  Gly Tyr Ile Cys Gln  Thr Arg Ser 
    1070                 1075                 1080             


Asp Pro  Ser Leu Thr Asn Pro  Pro Ala Thr Ile Gln  Thr Asp Gly 
    1085                 1090                 1095             


Phe Val  Lys Tyr Gly Lys Ser  Ser Tyr Ser Leu Met  Arg Gln Lys 
    1100                 1105                 1110             


Phe Gln  Trp His Glu Ala Glu  Thr Tyr Cys Lys Leu  His Asn Ser 
    1115                 1120                 1125             


Leu Ile  Ala Ser Ile Leu Asp  Pro Tyr Ser Asn Ala  Phe Ala Trp 
    1130                 1135                 1140             


Leu Gln  Met Glu Thr Ser Asn  Glu Arg Val Trp Ile  Ala Leu Asn 
    1145                 1150                 1155             


Ser Asn  Leu Thr Asp Asn Gln  Tyr Thr Trp Thr Asp  Lys Trp Arg 
    1160                 1165                 1170             


Val Arg  Tyr Thr Asn Trp Ala  Ala Asp Glu Pro Lys  Leu Lys Ser 
    1175                 1180                 1185             


Ala Cys  Val Tyr Leu Asp Leu  Asp Gly Tyr Trp Lys  Thr Ala His 
    1190                 1195                 1200             


Cys Asn  Glu Ser Phe Tyr Phe  Leu Cys Lys Arg Ser  Asp Glu Ile 
    1205                 1210                 1215             


Pro Ala  Thr Glu Pro Pro Gln  Leu Pro Gly Arg Cys  Pro Glu Ser 
    1220                 1225                 1230             


Asp His  Thr Ala Trp Ile Pro  Phe His Gly His Cys  Tyr Tyr Ile 
    1235                 1240                 1245             


Glu Ser  Ser Tyr Thr Arg Asn  Trp Gly Gln Ala Ser  Leu Glu Cys 
    1250                 1255                 1260             


Leu Arg  Met Gly Ser Ser Leu  Val Ser Ile Glu Ser  Ala Ala Glu 
    1265                 1270                 1275             


Ser Ser  Phe Leu Ser Tyr Arg  Val Glu Pro Leu Lys  Ser Lys Thr 
    1280                 1285                 1290             


Asn Phe  Trp Ile Gly Leu Phe  Arg Asn Val Glu Gly  Thr Trp Leu 
    1295                 1300                 1305             


Trp Ile  Asn Asn Ser Pro Val  Ser Phe Val Asn Trp  Asn Thr Gly 
    1310                 1315                 1320             


Asp Pro  Ser Gly Glu Arg Asn  Asp Cys Val Ala Leu  His Ala Ser 
    1325                 1330                 1335             


Ser Gly  Phe Trp Ser Asn Ile  His Cys Ser Ser Tyr  Lys Gly Tyr 
    1340                 1345                 1350             


Ile Cys  Lys Arg Pro Lys Ile  Ile Asp Ala Lys Pro  Thr His Glu 
    1355                 1360                 1365             


Leu Leu  Thr Thr Lys Ala Asp  Thr Arg Lys Met Asp  Pro Ser Lys 
    1370                 1375                 1380             


Pro Ser  Ser Asn Val Ala Gly  Val Val Ile Ile Val  Ile Leu Leu 
    1385                 1390                 1395             


Ile Leu  Thr Gly Ala Gly Leu  Ala Ala Tyr Phe Phe  Tyr Lys Lys 
    1400                 1405                 1410             


Arg Arg  Val His Leu Pro Gln  Glu Gly Ala Phe Glu  Asn Thr Leu 
    1415                 1420                 1425             


Tyr Phe  Asn Ser Gln Ser Ser  Pro Gly Thr Ser Asp  Met Lys Asp 
    1430                 1435                 1440             


Leu Val  Gly Asn Ile Glu Gln  Asn Glu His Ser Val  Ile 
    1445                 1450                 1455     


<210>  102
<211>  1121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CD163

<400>  102

Met Ser Lys Leu Arg Met Val Leu Leu Glu Asp Ser Gly Ser Ala Asp 
1               5                   10                  15      


Phe Arg Arg His Phe Val Asn Leu Ser Pro Phe Thr Ile Thr Val Val 
            20                  25                  30          


Leu Leu Leu Ser Ala Cys Phe Val Thr Ser Ser Leu Gly Gly Thr Asp 
        35                  40                  45              


Lys Glu Leu Arg Leu Val Asp Gly Glu Asn Lys Cys Ser Gly Arg Val 
    50                  55                  60                  


Glu Val Lys Val Gln Glu Glu Trp Gly Thr Val Cys Asn Asn Gly Trp 
65                  70                  75                  80  


Ser Met Glu Ala Val Ser Val Ile Cys Asn Gln Leu Gly Cys Pro Thr 
                85                  90                  95      


Ala Ile Lys Ala Pro Gly Trp Ala Asn Ser Ser Ala Gly Ser Gly Arg 
            100                 105                 110         


Ile Trp Met Asp His Val Ser Cys Arg Gly Asn Glu Ser Ala Leu Trp 
        115                 120                 125             


Asp Cys Lys His Asp Gly Trp Gly Lys His Ser Asn Cys Thr His Gln 
    130                 135                 140                 


Gln Asp Ala Gly Val Thr Cys Ser Asp Gly Ser Asn Leu Glu Met Arg 
145                 150                 155                 160 


Leu Thr Arg Gly Gly Asn Met Cys Ser Gly Arg Ile Glu Ile Lys Phe 
                165                 170                 175     


Gln Gly Arg Trp Gly Thr Val Cys Asp Asp Asn Phe Asn Ile Asp His 
            180                 185                 190         


Ala Ser Val Ile Cys Arg Gln Leu Glu Cys Gly Ser Ala Val Ser Phe 
        195                 200                 205             


Ser Gly Ser Ser Asn Phe Gly Glu Gly Ser Gly Pro Ile Trp Phe Asp 
    210                 215                 220                 


Asp Leu Ile Cys Asn Gly Asn Glu Ser Ala Leu Trp Asn Cys Lys His 
225                 230                 235                 240 


Gln Gly Trp Gly Lys His Asn Cys Asp His Ala Glu Asp Ala Gly Val 
                245                 250                 255     


Ile Cys Ser Lys Gly Ala Asp Leu Ser Leu Arg Leu Val Asp Gly Val 
            260                 265                 270         


Thr Glu Cys Ser Gly Arg Leu Glu Val Arg Phe Gln Gly Glu Trp Gly 
        275                 280                 285             


Thr Ile Cys Asp Asp Gly Trp Asp Ser Tyr Asp Ala Ala Val Ala Cys 
    290                 295                 300                 


Lys Gln Leu Gly Cys Pro Thr Ala Val Thr Ala Ile Gly Arg Val Asn 
305                 310                 315                 320 


Ala Ser Lys Gly Phe Gly His Ile Trp Leu Asp Ser Val Ser Cys Gln 
                325                 330                 335     


Gly His Glu Pro Ala Val Trp Gln Cys Lys His His Glu Trp Gly Lys 
            340                 345                 350         


His Tyr Cys Asn His Asn Glu Asp Ala Gly Val Thr Cys Ser Asp Gly 
        355                 360                 365             


Ser Asp Leu Glu Leu Arg Leu Arg Gly Gly Gly Ser Arg Cys Ala Gly 
    370                 375                 380                 


Thr Val Glu Val Glu Ile Gln Arg Leu Leu Gly Lys Val Cys Asp Arg 
385                 390                 395                 400 


Gly Trp Gly Leu Lys Glu Ala Asp Val Val Cys Arg Gln Leu Gly Cys 
                405                 410                 415     


Gly Ser Ala Leu Lys Thr Ser Tyr Gln Val Tyr Ser Lys Ile Gln Ala 
            420                 425                 430         


Thr Asn Thr Trp Leu Phe Leu Ser Ser Cys Asn Gly Asn Glu Thr Ser 
        435                 440                 445             


Leu Trp Asp Cys Lys Asn Trp Gln Trp Gly Gly Leu Thr Cys Asp His 
    450                 455                 460                 


Tyr Glu Glu Ala Lys Ile Thr Cys Ser Ala His Arg Glu Pro Arg Leu 
465                 470                 475                 480 


Val Gly Gly Asp Ile Pro Cys Ser Gly Arg Val Glu Val Lys His Gly 
                485                 490                 495     


Asp Thr Trp Gly Ser Ile Cys Asp Ser Asp Phe Ser Leu Glu Ala Ala 
            500                 505                 510         


Ser Val Leu Cys Arg Glu Leu Gln Cys Gly Thr Val Val Ser Ile Leu 
        515                 520                 525             


Gly Gly Ala His Phe Gly Glu Gly Asn Gly Gln Ile Trp Ala Glu Glu 
    530                 535                 540                 


Phe Gln Cys Glu Gly His Glu Ser His Leu Ser Leu Cys Pro Val Ala 
545                 550                 555                 560 


Pro Arg Pro Glu Gly Thr Cys Ser His Ser Arg Asp Val Gly Val Val 
                565                 570                 575     


Cys Ser Arg Tyr Thr Glu Ile Arg Leu Val Asn Gly Lys Thr Pro Cys 
            580                 585                 590         


Glu Gly Arg Val Glu Leu Lys Thr Leu Gly Ala Trp Gly Ser Leu Cys 
        595                 600                 605             


Asn Ser His Trp Asp Ile Glu Asp Ala His Val Leu Cys Gln Gln Leu 
    610                 615                 620                 


Lys Cys Gly Val Ala Leu Ser Thr Pro Gly Gly Ala Arg Phe Gly Lys 
625                 630                 635                 640 


Gly Asn Gly Gln Ile Trp Arg His Met Phe His Cys Thr Gly Thr Glu 
                645                 650                 655     


Gln His Met Gly Asp Cys Pro Val Thr Ala Leu Gly Ala Ser Leu Cys 
            660                 665                 670         


Pro Ser Glu Gln Val Ala Ser Val Ile Cys Ser Gly Asn Gln Ser Gln 
        675                 680                 685             


Thr Leu Ser Ser Cys Asn Ser Ser Ser Leu Gly Pro Thr Arg Pro Thr 
    690                 695                 700                 


Ile Pro Glu Glu Ser Ala Val Ala Cys Ile Glu Ser Gly Gln Leu Arg 
705                 710                 715                 720 


Leu Val Asn Gly Gly Gly Arg Cys Ala Gly Arg Val Glu Ile Tyr His 
                725                 730                 735     


Glu Gly Ser Trp Gly Thr Ile Cys Asp Asp Ser Trp Asp Leu Ser Asp 
            740                 745                 750         


Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Glu Ala Ile Asn Ala 
        755                 760                 765             


Thr Gly Ser Ala His Phe Gly Glu Gly Thr Gly Pro Ile Trp Leu Asp 
    770                 775                 780                 


Glu Met Lys Cys Asn Gly Lys Glu Ser Arg Ile Trp Gln Cys His Ser 
785                 790                 795                 800 


His Gly Trp Gly Gln Gln Asn Cys Arg His Lys Glu Asp Ala Gly Val 
                805                 810                 815     


Ile Cys Ser Glu Phe Met Ser Leu Arg Leu Thr Ser Glu Ala Ser Arg 
            820                 825                 830         


Glu Ala Cys Ala Gly Arg Leu Glu Val Phe Tyr Asn Gly Ala Trp Gly 
        835                 840                 845             


Thr Val Gly Lys Ser Ser Met Ser Glu Thr Thr Val Gly Val Val Cys 
    850                 855                 860                 


Arg Gln Leu Gly Cys Ala Asp Lys Gly Lys Ile Asn Pro Ala Ser Leu 
865                 870                 875                 880 


Asp Lys Ala Met Ser Ile Pro Met Trp Val Asp Asn Val Gln Cys Pro 
                885                 890                 895     


Lys Gly Pro Asp Thr Leu Trp Gln Cys Pro Ser Ser Pro Trp Glu Lys 
            900                 905                 910         


Arg Leu Ala Ser Pro Ser Glu Glu Thr Trp Ile Thr Cys Asp Asn Lys 
        915                 920                 925             


Ile Arg Leu Gln Glu Gly Pro Thr Ser Cys Ser Gly Arg Val Glu Ile 
    930                 935                 940                 


Trp His Gly Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Leu 
945                 950                 955                 960 


Asp Asp Ala Gln Val Val Cys Gln Gln Leu Gly Cys Gly Pro Ala Leu 
                965                 970                 975     


Lys Ala Phe Lys Glu Ala Glu Phe Gly Gln Gly Thr Gly Pro Ile Trp 
            980                 985                 990         


Leu Asn Glu Val Lys Cys Lys Gly  Asn Glu Ser Ser Leu  Trp Asp Cys 
        995                 1000                 1005             


Pro Ala  Arg Arg Trp Gly His  Ser Glu Cys Gly His  Lys Glu Asp 
    1010                 1015                 1020             


Ala Ala  Val Asn Cys Thr Asp  Ile Ser Val Gln Lys  Thr Pro Gln 
    1025                 1030                 1035             


Lys Ala  Thr Thr Gly Arg Ser  Ser Arg Gln Ser Ser  Phe Ile Ala 
    1040                 1045                 1050             


Val Gly  Ile Leu Gly Val Val  Leu Leu Ala Ile Phe  Val Ala Leu 
    1055                 1060                 1065             


Phe Phe  Leu Thr Lys Lys Arg  Arg Gln Arg Gln Arg  Leu Ala Val 
    1070                 1075                 1080             


Ser Ser  Arg Gly Glu Asn Leu  Val His Gln Ile Gln  Tyr Arg Glu 
    1085                 1090                 1095             


Met Asn  Ser Cys Leu Asn Ala  Asp Asp Leu Asp Leu  Met Asn Ser 
    1100                 1105                 1110             


Ser Gly  Gly His Ser Glu Pro  His 
    1115                 1120     


<210>  103
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Fn14

<400>  103

Met Ala Arg Gly Ser Leu Arg Arg Leu Leu Arg Leu Leu Val Leu Gly 
1               5                   10                  15      


Leu Trp Leu Ala Leu Leu Arg Ser Val Ala Gly Glu Gln Ala Pro Gly 
            20                  25                  30          


Thr Ala Pro Cys Ser Arg Gly Ser Ser Trp Ser Ala Asp Leu Asp Lys 
        35                  40                  45              


Cys Met Asp Cys Ala Ser Cys Arg Ala Arg Pro His Ser Asp Phe Cys 
    50                  55                  60                  


Leu Gly Cys Ala Ala Ala Pro Pro Ala Pro Phe Arg Leu Leu Trp Pro 
65                  70                  75                  80  


Ile Leu Gly Gly Ala Leu Ser Leu Thr Phe Val Leu Gly Leu Leu Ser 
                85                  90                  95      


Gly Phe Leu Val Trp Arg Arg Cys Arg Arg Arg Glu Lys Phe Thr Thr 
            100                 105                 110         


Pro Ile Glu Glu Thr Gly Gly Glu Gly Cys Pro Ala Val Ala Leu Ile 
        115                 120                 125             


Gln 

    
<210> 104

<400> 104
000


<210>  105
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader sequence

<400>  105

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser 
            

<210> 106

<400> 106
000

<210> 107

<400> 107
000

<210> 108

<400> 108
000

<210> 109

<400> 109
000


<210>  110
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD206 nanobody NbMMRm22.84

<400>  110

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Asn Tyr Ala Met Gly Trp Phe Arg Gln Phe Pro Gly Lys Glu Arg 
        35                  40                  45              


Glu Phe Val Ala Ser Ile Ser Trp Ser Ser Val Thr Thr Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala His Leu Ala Gln Tyr Ser Asp Tyr Ala Tyr Arg 
            100                 105                 110         


Asp Pro His Gln Phe Gly Ala Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  111
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD206 nanobody NbMMRm22.84 CDR1

<400>  111

Gly Arg Thr Phe Ser Asn Tyr Val Asn Tyr Ala Met Gly 
1               5                   10              


<210>  112
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD206 nanobody NbMMRm22.84 CDR2

<400>  112

Ser Ile Ser Trp Ser Ser Val Thr Thr 
1               5                   


<210>  113
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD206 nanobody NbMMRm22.84 CDR3

<400>  113

His Leu Ala Gln Tyr Ser Asp Tyr Ala Tyr Arg Asp Pro His Gln Phe 
1               5                   10                  15      


Gly Ala 
        


<210>  114
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD206 nanobody NbMMRm5.38

<400>  114

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asp Asp Asp Tyr 
            20                  25                  30          


Asp Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Phe Phe Arg Trp Asp Ser Gly Ser Tyr Tyr Val Arg Gly 
            100                 105                 110         


Cys Arg His Ala Thr Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  115
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD206 nanobody NbMMRm5.38 CDR1

<400>  115

Gly Phe Thr Asp Asp Asp Tyr Asp Ile Gly 
1               5                   10  


<210>  116
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD206 nanobody NbMMRm5.38 CDR2

<400>  116

Cys Ile Ser Ser Ser Asp Gly Ser Thr 
1               5                   


<210>  117
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD206 nanobody NbMMRm5.38 CDR3

<400>  117

Asp Phe Phe Arg Trp Asp Ser Gly Ser Tyr Tyr Val Arg Gly Cys Arg 
1               5                   10                  15      


His Ala Thr Tyr Asp Tyr 
            20          


<210>  118
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 antibody AbP4A8 heavy chain variable domain (P4A8VH)

<400>  118

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  119
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 antibody AbP4A8 heavy chain variable domain CDR1

<400>  119

Asp Tyr Gly Met His 
1               5   


<210>  120
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 antibody AbP4A8 heavy chain variable domain CDR2

<400>  120

Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  121
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 antibody AbP4A8 heavy chain variable domain CDR3

<400>  121

Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  122
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 antibody AbP4A8 light chain variable domain (P4A8VL)

<400>  122

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  123
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 antibody AbP4A8 light chain variable domain CDR1

<400>  123

Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  124
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 antibody AbP4A8 light chain variable domain CDR2

<400>  124

Ala Ser Asn Leu Glu Ser 
1               5      


<210>  125
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 antibody AbP4A8 light chain variable domain CDR3

<400>  125

Gln His Ser Arg Glu Leu Pro Phe Thr 
1               5                   


<210>  126
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 antibody AbP3G5 heavy chain variable domain (P3G5VH)

<400>  126

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Ile His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  127
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 antibody AbP3G5 heavy chain variable domain CDR1

<400>  127

Asp Tyr Gly Ile His 
1               5   


<210>  128
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 antibody AbP3G5 heavy chain variable domain CDR2

<400>  128

Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  129
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 antibody AbP3G5 heavy chain variable domain CDR3

<400>  129

Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  130
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 antibody AbP3G5 light chain variable domain (P3G5VL)

<400>  130

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Asn Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  131
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 antibody AbP3G5 light chain variable domain CDR1

<400>  131

Arg Ala Asn Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  132
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 antibody AbP3G5 light chain variable domain CDR2

<400>  132

Ala Ser Asn Leu Glu Ser 
1               5       


<210>  133
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 antibody AbP3G5 light chain variable domain CDR3

<400>  133

Gln His Ser Arg Glu Leu Pro Phe Thr 
1               5                   


<210>  134
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human TWEAK (without Met/ATG)

<400>  134

Ala Ala Arg Arg Ser Gln Arg Arg Arg Gly Arg Arg Gly Glu Pro Gly 
1               5                   10                  15      


Thr Ala Leu Leu Val Pro Leu Ala Leu Gly Leu Gly Leu Ala Leu Ala 
            20                  25                  30          


Cys Leu Gly Leu Leu Leu Ala Val Val Ser Leu Gly Ser Arg Ala Ser 
        35                  40                  45              


Leu Ser Ala Gln Glu Pro Ala Gln Glu Glu Leu Val Ala Glu Glu Asp 
    50                  55                  60                  


Gln Asp Pro Ser Glu Leu Asn Pro Gln Thr Glu Glu Ser Gln Asp Pro 
65                  70                  75                  80  


Ala Pro Phe Leu Asn Arg Leu Val Arg Pro Arg Arg Ser Ala Pro Lys 
                85                  90                  95      


Gly Arg Lys Thr Arg Ala Arg Arg Ala Ile Ala Ala His Tyr Glu Val 
            100                 105                 110         


His Pro Arg Pro Gly Gln Asp Gly Ala Gln Ala Gly Val Asp Gly Thr 
        115                 120                 125             


Val Ser Gly Trp Glu Glu Ala Arg Ile Asn Ser Ser Ser Pro Leu Arg 
    130                 135                 140                 


Tyr Asn Arg Gln Ile Gly Glu Phe Ile Val Thr Arg Ala Gly Leu Tyr 
145                 150                 155                 160 


Tyr Leu Tyr Cys Gln Val His Phe Asp Glu Gly Lys Ala Val Tyr Leu 
                165                 170                 175     


Lys Leu Asp Leu Leu Val Asp Gly Val Leu Ala Leu Arg Cys Leu Glu 
            180                 185                 190         


Glu Phe Ser Ala Thr Ala Ala Ser Ser Leu Gly Pro Gln Leu Arg Leu 
        195                 200                 205             


Cys Gln Val Ser Gly Leu Leu Ala Leu Arg Pro Gly Ser Ser Leu Arg 
    210                 215                 220                 


Ile Arg Thr Leu Pro Trp Ala His Leu Lys Ala Ala Pro Phe Leu Thr 
225                 230                 235                 240 


Tyr Phe Gly Leu Phe Gln Val His 
                245             


<210>  135
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse TWEAK (without Met/ATG)

<400>  135

Ala Ala Arg Arg Ser Gln Arg Arg Arg Gly Arg Arg Gly Glu Pro Gly 
1               5                   10                  15      


Thr Ala Leu Leu Ala Pro Leu Val Leu Ser Leu Gly Leu Ala Leu Ala 
            20                  25                  30          


Cys Leu Gly Leu Leu Leu Val Val Val Ser Leu Gly Ser Trp Ala Thr 
        35                  40                  45              


Leu Ser Ala Gln Glu Pro Ser Gln Glu Glu Leu Thr Ala Glu Asp Arg 
    50                  55                  60                  


Arg Glu Pro Pro Glu Leu Asn Pro Gln Thr Glu Glu Ser Gln Asp Val 
65                  70                  75                  80  


Val Pro Phe Leu Glu Gln Leu Val Arg Pro Arg Arg Ser Ala Pro Lys 
                85                  90                  95      


Gly Arg Lys Ala Arg Pro Arg Arg Ala Ile Ala Ala His Tyr Glu Val 
            100                 105                 110         


His Pro Arg Pro Gly Gln Asp Gly Ala Gln Ala Gly Val Asp Gly Thr 
        115                 120                 125             


Val Ser Gly Trp Glu Glu Thr Lys Ile Asn Ser Ser Ser Pro Leu Arg 
    130                 135                 140                 


Tyr Asp Arg Gln Ile Gly Glu Phe Thr Val Ile Arg Ala Gly Leu Tyr 
145                 150                 155                 160 


Tyr Leu Tyr Cys Gln Val His Phe Asp Glu Gly Lys Ala Val Tyr Leu 
                165                 170                 175     


Lys Leu Asp Leu Leu Val Asn Gly Val Leu Ala Leu Arg Cys Leu Glu 
            180                 185                 190         


Glu Phe Ser Ala Thr Ala Ala Ser Ser Pro Gly Pro Gln Leu Arg Leu 
        195                 200                 205             


Cys Gln Val Ser Gly Leu Leu Pro Leu Arg Pro Gly Ser Ser Leu Arg 
    210                 215                 220                 


Ile Arg Thr Leu Pro Trp Ala His Leu Lys Ala Ala Pro Phe Leu Thr 
225                 230                 235                 240 


Tyr Phe Gly Leu Phe Gln Val His 
                245             


<210>  136
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3zICS-CD28CS-TWEAK

<400>  136

Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    50                  55                  60                  


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
65                  70                  75                  80  


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                85                  90                  95      


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            100                 105                 110         


Pro Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
        115                 120                 125             


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
    130                 135                 140                 


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Ala Ala Arg Arg Ser Gln 
145                 150                 155                 160 


Arg Arg Arg Gly Arg Arg Gly Glu Pro Gly Thr Ala Leu Leu Val Pro 
                165                 170                 175     


Leu Ala Leu Gly Leu Gly Leu Ala Leu Ala Cys Leu Gly Leu Leu Leu 
            180                 185                 190         


Ala Val Val Ser Leu Gly Ser Arg Ala Ser Leu Ser Ala Gln Glu Pro 
        195                 200                 205             


Ala Gln Glu Glu Leu Val Ala Glu Glu Asp Gln Asp Pro Ser Glu Leu 
    210                 215                 220                 


Asn Pro Gln Thr Glu Glu Ser Gln Asp Pro Ala Pro Phe Leu Asn Arg 
225                 230                 235                 240 


Leu Val Arg Pro Arg Arg Ser Ala Pro Lys Gly Arg Lys Thr Arg Ala 
                245                 250                 255     


Arg Arg Ala Ile Ala Ala His Tyr Glu Val His Pro Arg Pro Gly Gln 
            260                 265                 270         


Asp Gly Ala Gln Ala Gly Val Asp Gly Thr Val Ser Gly Trp Glu Glu 
        275                 280                 285             


Ala Arg Ile Asn Ser Ser Ser Pro Leu Arg Tyr Asn Arg Gln Ile Gly 
    290                 295                 300                 


Glu Phe Ile Val Thr Arg Ala Gly Leu Tyr Tyr Leu Tyr Cys Gln Val 
305                 310                 315                 320 


His Phe Asp Glu Gly Lys Ala Val Tyr Leu Lys Leu Asp Leu Leu Val 
                325                 330                 335     


Asp Gly Val Leu Ala Leu Arg Cys Leu Glu Glu Phe Ser Ala Thr Ala 
            340                 345                 350         


Ala Ser Ser Leu Gly Pro Gln Leu Arg Leu Cys Gln Val Ser Gly Leu 
        355                 360                 365             


Leu Ala Leu Arg Pro Gly Ser Ser Leu Arg Ile Arg Thr Leu Pro Trp 
    370                 375                 380                 


Ala His Leu Lys Ala Ala Pro Phe Leu Thr Tyr Phe Gly Leu Phe Gln 
385                 390                 395                 400 


Val His 
        


<210>  137
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3zICS-41BBCS-TWEAK

<400>  137

Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    50                  55                  60                  


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
65                  70                  75                  80  


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                85                  90                  95      


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            100                 105                 110         


Pro Arg Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        115                 120                 125             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    130                 135                 140                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Ala Ala Arg Arg 
145                 150                 155                 160 


Ser Gln Arg Arg Arg Gly Arg Arg Gly Glu Pro Gly Thr Ala Leu Leu 
                165                 170                 175     


Val Pro Leu Ala Leu Gly Leu Gly Leu Ala Leu Ala Cys Leu Gly Leu 
            180                 185                 190         


Leu Leu Ala Val Val Ser Leu Gly Ser Arg Ala Ser Leu Ser Ala Gln 
        195                 200                 205             


Glu Pro Ala Gln Glu Glu Leu Val Ala Glu Glu Asp Gln Asp Pro Ser 
    210                 215                 220                 


Glu Leu Asn Pro Gln Thr Glu Glu Ser Gln Asp Pro Ala Pro Phe Leu 
225                 230                 235                 240 


Asn Arg Leu Val Arg Pro Arg Arg Ser Ala Pro Lys Gly Arg Lys Thr 
                245                 250                 255     


Arg Ala Arg Arg Ala Ile Ala Ala His Tyr Glu Val His Pro Arg Pro 
            260                 265                 270         


Gly Gln Asp Gly Ala Gln Ala Gly Val Asp Gly Thr Val Ser Gly Trp 
        275                 280                 285             


Glu Glu Ala Arg Ile Asn Ser Ser Ser Pro Leu Arg Tyr Asn Arg Gln 
    290                 295                 300                 


Ile Gly Glu Phe Ile Val Thr Arg Ala Gly Leu Tyr Tyr Leu Tyr Cys 
305                 310                 315                 320 


Gln Val His Phe Asp Glu Gly Lys Ala Val Tyr Leu Lys Leu Asp Leu 
                325                 330                 335     


Leu Val Asp Gly Val Leu Ala Leu Arg Cys Leu Glu Glu Phe Ser Ala 
            340                 345                 350         


Thr Ala Ala Ser Ser Leu Gly Pro Gln Leu Arg Leu Cys Gln Val Ser 
        355                 360                 365             


Gly Leu Leu Ala Leu Arg Pro Gly Ser Ser Leu Arg Ile Arg Thr Leu 
    370                 375                 380                 


Pro Trp Ala His Leu Lys Ala Ala Pro Phe Leu Thr Tyr Phe Gly Leu 
385                 390                 395                 400 


Phe Gln Val His 
                


<210>  138
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3zICS-DAP10CS-TWEAK

<400>  138

Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    50                  55                  60                  


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
65                  70                  75                  80  


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                85                  90                  95      


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            100                 105                 110         


Pro Arg Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly 
        115                 120                 125             


Lys Val Tyr Ile Asn Met Pro Gly Arg Gly Ala Ala Arg Arg Ser Gln 
    130                 135                 140                 


Arg Arg Arg Gly Arg Arg Gly Glu Pro Gly Thr Ala Leu Leu Val Pro 
145                 150                 155                 160 


Leu Ala Leu Gly Leu Gly Leu Ala Leu Ala Cys Leu Gly Leu Leu Leu 
                165                 170                 175     


Ala Val Val Ser Leu Gly Ser Arg Ala Ser Leu Ser Ala Gln Glu Pro 
            180                 185                 190         


Ala Gln Glu Glu Leu Val Ala Glu Glu Asp Gln Asp Pro Ser Glu Leu 
        195                 200                 205             


Asn Pro Gln Thr Glu Glu Ser Gln Asp Pro Ala Pro Phe Leu Asn Arg 
    210                 215                 220                 


Leu Val Arg Pro Arg Arg Ser Ala Pro Lys Gly Arg Lys Thr Arg Ala 
225                 230                 235                 240 


Arg Arg Ala Ile Ala Ala His Tyr Glu Val His Pro Arg Pro Gly Gln 
                245                 250                 255     


Asp Gly Ala Gln Ala Gly Val Asp Gly Thr Val Ser Gly Trp Glu Glu 
            260                 265                 270         


Ala Arg Ile Asn Ser Ser Ser Pro Leu Arg Tyr Asn Arg Gln Ile Gly 
        275                 280                 285             


Glu Phe Ile Val Thr Arg Ala Gly Leu Tyr Tyr Leu Tyr Cys Gln Val 
    290                 295                 300                 


His Phe Asp Glu Gly Lys Ala Val Tyr Leu Lys Leu Asp Leu Leu Val 
305                 310                 315                 320 


Asp Gly Val Leu Ala Leu Arg Cys Leu Glu Glu Phe Ser Ala Thr Ala 
                325                 330                 335     


Ala Ser Ser Leu Gly Pro Gln Leu Arg Leu Cys Gln Val Ser Gly Leu 
            340                 345                 350         


Leu Ala Leu Arg Pro Gly Ser Ser Leu Arg Ile Arg Thr Leu Pro Trp 
        355                 360                 365             


Ala His Leu Lys Ala Ala Pro Phe Leu Thr Tyr Phe Gly Leu Phe Gln 
    370                 375                 380                 


Val His 
385     


<210>  139
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker subunit (G4S)

<400>  139

Gly Gly Gly Gly Ser 
1               5   


<210>  140
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker (G4S X3)

<400>  140

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  141
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 scFvP4A8VHVL

<400>  141

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Ile Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  142
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 scFvP4A8VLVH

<400>  142

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        115                 120                 125             


Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val Ser Val 
    130                 135                 140                 


Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr Gly Met 
145                 150                 155                 160 


His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile Gly Val 
                165                 170                 175     


Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Gly 
            180                 185                 190         


Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
        195                 200                 205             


Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser 
                245         


<210>  143
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 scFvP3G5VHVL

<400>  143

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Ile His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg 
145                 150                 155                 160 


Ala Asn Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Ile Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  144
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 scFvP3G5VLVH

<400>  144

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Asn Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        115                 120                 125             


Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val Ser Val 
    130                 135                 140                 


Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr Gly Ile 
145                 150                 155                 160 


His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile Gly Val 
                165                 170                 175     


Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Gly 
            180                 185                 190         


Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
        195                 200                 205             


Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser 
                245         


<210>  145
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CD28 hinge (CD28H)

<400>  145

Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser 
1               5                   10                  15      


Lys Pro 
        


<210>  146
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CD28 transmembrane domain (CD28TM)

<400>  146

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  147
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CD3 zeta intracellular signaling domain (CD3zICS)

<400>  147

Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    50                  55                  60                  


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
65                  70                  75                  80  


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                85                  90                  95      


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            100                 105                 110         


Pro Arg 
        

<210> 148

<400> 148
000

<210> 149

<400> 149
000


<210>  150
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A ribosomal skip sequence (T2A)

<400>  150

Ala Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu 
1               5                   10                  15      


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25          


<210>  151
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human truncated CD19 (trCD19)

<400>  151

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Thr 
                325         


<210> 152

<400> 152
000

<210> 153

<400> 153
000

<210> 154

<400> 154
000


<210>  155
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CD27 costimulatory domain (CD27CS)

<400>  155

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  156
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CD28 costimulatory domain (CD28CS)

<400>  156

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40  


<210>  157
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB costimulatory domain (41BBCS)

<400>  157

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  158
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAP10 costimulatory domain (DAP10CS)

<400>  158

Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val 
1               5                   10                  15      


Tyr Ile Asn Met Pro Gly Arg Gly 
            20                  


<210> 159

<400> 159
000


<210>  160
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NbMMRm22.84-CD28H-CD28TM-CD28CS-CD3zICS

<400>  160

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Asn Tyr Ala Met Gly Trp Phe Arg Gln Phe Pro Gly Lys Glu Arg 
        35                  40                  45              


Glu Phe Val Ala Ser Ile Ser Trp Ser Ser Val Thr Thr Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala His Leu Ala Gln Tyr Ser Asp Tyr Ala Tyr Arg 
            100                 105                 110         


Asp Pro His Gln Phe Gly Ala Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly 
    130                 135                 140                 


Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
145                 150                 155                 160 


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Ser 
                165                 170                 175     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            180                 185                 190         


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        195                 200                 205             


Asp Phe Ala Ala Tyr Arg Ser Leu Arg Val Lys Phe Ser Arg Ser Ala 
    210                 215                 220                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
225                 230                 235                 240 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                245                 250                 255     


Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
            260                 265                 270         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        275                 280                 285             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    290                 295                 300                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
305                 310                 315                 320 


Leu His Met Gln Ala Leu Pro Pro Arg 
                325                 


<210>  161
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NbMMRm5.38-CD28H-CD28TM-CD28CS-CD3zICS

<400>  161

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asp Asp Asp Tyr 
            20                  25                  30          


Asp Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Phe Phe Arg Trp Asp Ser Gly Ser Tyr Tyr Val Arg Gly 
            100                 105                 110         


Cys Arg His Ala Thr Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro 
    130                 135                 140                 


Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
145                 150                 155                 160 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
                165                 170                 175     


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
            180                 185                 190         


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
        195                 200                 205             


Arg Asp Phe Ala Ala Tyr Arg Ser Leu Arg Val Lys Phe Ser Arg Ser 
    210                 215                 220                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
225                 230                 235                 240 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                245                 250                 255     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
            260                 265                 270         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        275                 280                 285             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    290                 295                 300                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
305                 310                 315                 320 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                325                 330 


<210>  162
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFvP4A8VHVL-CD28H-CD28TM-CD28CS-CD3zICS

<400>  162

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Ile Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys Val Lys Gly Lys His Leu Cys Pro Ser 
                245                 250                 255     


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
            260                 265                 270         


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
        275                 280                 285             


Ile Phe Trp Val Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
    290                 295                 300                 


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
305                 310                 315                 320 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Leu Arg Val Lys 
                325                 330                 335     


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
            340                 345                 350         


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
        355                 360                 365             


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
    370                 375                 380                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
385                 390                 395                 400 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                405                 410                 415     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            420                 425                 430         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445     


<210>  163
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFvP4A8VLVH-CD28H-CD28TM-CD28CS-CD3zICS

<400>  163

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        115                 120                 125             


Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val Ser Val 
    130                 135                 140                 


Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr Gly Met 
145                 150                 155                 160 


His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile Gly Val 
                165                 170                 175     


Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Gly 
            180                 185                 190         


Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
        195                 200                 205             


Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser Val Lys Gly Lys His Leu Cys Pro Ser 
                245                 250                 255     


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
            260                 265                 270         


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
        275                 280                 285             


Ile Phe Trp Val Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
    290                 295                 300                 


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
305                 310                 315                 320 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Leu Arg Val Lys 
                325                 330                 335     


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
            340                 345                 350         


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
        355                 360                 365             


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
    370                 375                 380                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
385                 390                 395                 400 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                405                 410                 415     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            420                 425                 430         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445     


<210>  164
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFvP3G5VHVL-CD28H-CD28TM-CD28CS-CD3zICS

<400>  164

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Ile His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg 
145                 150                 155                 160 


Ala Asn Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Ile Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys Val Lys Gly Lys His Leu Cys Pro Ser 
                245                 250                 255     


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
            260                 265                 270         


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
        275                 280                 285             


Ile Phe Trp Val Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
    290                 295                 300                 


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
305                 310                 315                 320 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Leu Arg Val Lys 
                325                 330                 335     


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
            340                 345                 350         


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
        355                 360                 365             


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
    370                 375                 380                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
385                 390                 395                 400 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                405                 410                 415     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            420                 425                 430         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445     


<210>  165
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFvP3G5VLVH-CD28H-CD28TM-CD28CS-CD3zICS

<400>  165

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Asn Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        115                 120                 125             


Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val Ser Val 
    130                 135                 140                 


Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr Gly Ile 
145                 150                 155                 160 


His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile Gly Val 
                165                 170                 175     


Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Gly 
            180                 185                 190         


Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
        195                 200                 205             


Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser Val Lys Gly Lys His Leu Cys Pro Ser 
                245                 250                 255     


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
            260                 265                 270         


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
        275                 280                 285             


Ile Phe Trp Val Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
    290                 295                 300                 


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
305                 310                 315                 320 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Leu Arg Val Lys 
                325                 330                 335     


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
            340                 345                 350         


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
        355                 360                 365             


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
    370                 375                 380                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
385                 390                 395                 400 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                405                 410                 415     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            420                 425                 430         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445     


<210>  166
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NbMMRm22.84-CD28H-CD28TM-41BBCS-CD3zICS

<400>  166

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Asn Tyr Ala Met Gly Trp Phe Arg Gln Phe Pro Gly Lys Glu Arg 
        35                  40                  45              


Glu Phe Val Ala Ser Ile Ser Trp Ser Ser Val Thr Thr Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala His Leu Ala Gln Tyr Ser Asp Tyr Ala Tyr Arg 
            100                 105                 110         


Asp Pro His Gln Phe Gly Ala Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly 
    130                 135                 140                 


Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
145                 150                 155                 160 


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys 
                165                 170                 175     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            180                 185                 190         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        195                 200                 205             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Leu Arg Val Lys Phe Ser Arg 
    210                 215                 220                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
225                 230                 235                 240 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                245                 250                 255     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
            260                 265                 270         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        275                 280                 285             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    290                 295                 300                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
305                 310                 315                 320 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                325                 330     


<210>  167
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NbMMRm5.38-CD28H-CD28TM-41BBCS-CD3zICS

<400>  167

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asp Asp Asp Tyr 
            20                  25                  30          


Asp Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Phe Phe Arg Trp Asp Ser Gly Ser Tyr Tyr Val Arg Gly 
            100                 105                 110         


Cys Arg His Ala Thr Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro 
    130                 135                 140                 


Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
145                 150                 155                 160 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
                165                 170                 175     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            180                 185                 190         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        195                 200                 205             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Leu Arg Val Lys Phe Ser 
    210                 215                 220                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
225                 230                 235                 240 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                245                 250                 255     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
            260                 265                 270         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        275                 280                 285             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    290                 295                 300                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
305                 310                 315                 320 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                325                 330         


<210>  168
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFvP4A8VHVL-CD28H-CD28TM-41BBCS-CD3zICS

<400>  168

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Ile Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys Val Lys Gly Lys His Leu Cys Pro Ser 
                245                 250                 255     


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
            260                 265                 270         


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
        275                 280                 285             


Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    290                 295                 300                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
305                 310                 315                 320 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Leu Arg 
                325                 330                 335     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
            340                 345                 350         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        355                 360                 365             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    370                 375                 380                 


Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
385                 390                 395                 400 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                405                 410                 415     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            420                 425                 430         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445             


<210>  169
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFvP4A8VLVH-CD28H-CD28TM-41BBCS-CD3zICS

<400>  169

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        115                 120                 125             


Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val Ser Val 
    130                 135                 140                 


Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr Gly Met 
145                 150                 155                 160 


His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile Gly Val 
                165                 170                 175     


Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Gly 
            180                 185                 190         


Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
        195                 200                 205             


Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser Val Lys Gly Lys His Leu Cys Pro Ser 
                245                 250                 255     


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
            260                 265                 270         


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
        275                 280                 285             


Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    290                 295                 300                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
305                 310                 315                 320 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Leu Arg 
                325                 330                 335     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
            340                 345                 350         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        355                 360                 365             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    370                 375                 380                 


Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
385                 390                 395                 400 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                405                 410                 415     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            420                 425                 430         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445             


<210>  170
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFvP3G5VHVL-CD28H-CD28TM-41BBCS-CD3zICS

<400>  170

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Ile His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg 
145                 150                 155                 160 


Ala Asn Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Ile Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys Val Lys Gly Lys His Leu Cys Pro Ser 
                245                 250                 255     


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
            260                 265                 270         


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
        275                 280                 285             


Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    290                 295                 300                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
305                 310                 315                 320 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Leu Arg 
                325                 330                 335     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
            340                 345                 350         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        355                 360                 365             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    370                 375                 380                 


Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
385                 390                 395                 400 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                405                 410                 415     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            420                 425                 430         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445             


<210>  171
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFvP3G5VLVH-CD28H-CD28TM-41BBCS-CD3zICS

<400>  171

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Asn Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        115                 120                 125             


Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val Ser Val 
    130                 135                 140                 


Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr Gly Ile 
145                 150                 155                 160 


His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile Gly Val 
                165                 170                 175     


Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Gly 
            180                 185                 190         


Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
        195                 200                 205             


Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser Val Lys Gly Lys His Leu Cys Pro Ser 
                245                 250                 255     


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
            260                 265                 270         


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
        275                 280                 285             


Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    290                 295                 300                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
305                 310                 315                 320 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Leu Arg 
                325                 330                 335     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
            340                 345                 350         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        355                 360                 365             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    370                 375                 380                 


Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
385                 390                 395                 400 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                405                 410                 415     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            420                 425                 430         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445             


<210>  172
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NbMMRm22.84-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  172

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Asn Tyr Ala Met Gly Trp Phe Arg Gln Phe Pro Gly Lys Glu Arg 
        35                  40                  45              


Glu Phe Val Ala Ser Ile Ser Trp Ser Ser Val Thr Thr Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala His Leu Ala Gln Tyr Ser Asp Tyr Ala Tyr Arg 
            100                 105                 110         


Asp Pro His Gln Phe Gly Ala Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly 
    130                 135                 140                 


Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
145                 150                 155                 160 


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Leu 
                165                 170                 175     


Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val Tyr 
            180                 185                 190         


Ile Asn Met Pro Gly Arg Gly Leu Arg Val Lys Phe Ser Arg Ser Ala 
        195                 200                 205             


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    210                 215                 220                 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
225                 230                 235                 240 


Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
                245                 250                 255     


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
            260                 265                 270         


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
        275                 280                 285             


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
    290                 295                 300                 


Leu His Met Gln Ala Leu Pro Pro Arg 
305                 310             


<210>  173
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NbMMRm5.38-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  173

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asp Asp Asp Tyr 
            20                  25                  30          


Asp Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Phe Phe Arg Trp Asp Ser Gly Ser Tyr Tyr Val Arg Gly 
            100                 105                 110         


Cys Arg His Ala Thr Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro 
    130                 135                 140                 


Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
145                 150                 155                 160 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
                165                 170                 175     


Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val 
            180                 185                 190         


Tyr Ile Asn Met Pro Gly Arg Gly Leu Arg Val Lys Phe Ser Arg Ser 
        195                 200                 205             


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    210                 215                 220                 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
225                 230                 235                 240 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
                245                 250                 255     


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            260                 265                 270         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        275                 280                 285             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    290                 295                 300                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
305                 310                 


<210>  174
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFvP4A8VHVL-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  174

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Ile Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys Val Lys Gly Lys His Leu Cys Pro Ser 
                245                 250                 255     


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
            260                 265                 270         


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
        275                 280                 285             


Ile Phe Trp Val Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu 
    290                 295                 300                 


Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly Leu Arg Val Lys 
305                 310                 315                 320 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
                325                 330                 335     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            340                 345                 350         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
        355                 360                 365             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    370                 375                 380                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
385                 390                 395                 400 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                405                 410                 415     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425                 430 


<210>  175
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFvP4A8VLVH-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  175

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        115                 120                 125             


Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val Ser Val 
    130                 135                 140                 


Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr Gly Met 
145                 150                 155                 160 


His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile Gly Val 
                165                 170                 175     


Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Gly 
            180                 185                 190         


Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
        195                 200                 205             


Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser Val Lys Gly Lys His Leu Cys Pro Ser 
                245                 250                 255     


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
            260                 265                 270         


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
        275                 280                 285             


Ile Phe Trp Val Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu 
    290                 295                 300                 


Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly Leu Arg Val Lys 
305                 310                 315                 320 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
                325                 330                 335     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            340                 345                 350         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
        355                 360                 365             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    370                 375                 380                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
385                 390                 395                 400 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                405                 410                 415     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425                 430 


<210>  176
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFvP3G5VHVL-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  176

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Ile His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg 
145                 150                 155                 160 


Ala Asn Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Ile Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys Val Lys Gly Lys His Leu Cys Pro Ser 
                245                 250                 255     


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
            260                 265                 270         


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
        275                 280                 285             


Ile Phe Trp Val Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu 
    290                 295                 300                 


Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly Leu Arg Val Lys 
305                 310                 315                 320 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
                325                 330                 335     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            340                 345                 350         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
        355                 360                 365             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    370                 375                 380                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
385                 390                 395                 400 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                405                 410                 415     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425                 430 


<210>  177
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFvP3G5VLVH-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  177

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Asn Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        115                 120                 125             


Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val Ser Val 
    130                 135                 140                 


Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr Gly Ile 
145                 150                 155                 160 


His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile Gly Val 
                165                 170                 175     


Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Gly 
            180                 185                 190         


Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
        195                 200                 205             


Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser Val Lys Gly Lys His Leu Cys Pro Ser 
                245                 250                 255     


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
            260                 265                 270         


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
        275                 280                 285             


Ile Phe Trp Val Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu 
    290                 295                 300                 


Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly Leu Arg Val Lys 
305                 310                 315                 320 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
                325                 330                 335     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            340                 345                 350         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
        355                 360                 365             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    370                 375                 380                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
385                 390                 395                 400 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                405                 410                 415     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425                 430 


<210>  178
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm22.84-CD28H-CD28TM-CD28CS-CD3zICS-T2A-trCD19

<400>  178

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
        35                  40                  45              


Ser Asn Tyr Val Asn Tyr Ala Met Gly Trp Phe Arg Gln Phe Pro Gly 
    50                  55                  60                  


Lys Glu Arg Glu Phe Val Ala Ser Ile Ser Trp Ser Ser Val Thr Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Ala His Leu Ala Gln Tyr Ser Asp Tyr 
        115                 120                 125             


Ala Tyr Arg Asp Pro His Gln Phe Gly Ala Trp Gly Gln Gly Thr Gln 
    130                 135                 140                 


Val Thr Val Ser Ser Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
145                 150                 155                 160 


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
                165                 170                 175     


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
            180                 185                 190         


Trp Val Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
        195                 200                 205             


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
    210                 215                 220                 


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Leu Arg Val Lys Phe Ser 
225                 230                 235                 240 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
                245                 250                 255     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            260                 265                 270         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
        275                 280                 285             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    290                 295                 300                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
305                 310                 315                 320 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                325                 330                 335     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ala Arg Ala Lys 
            340                 345                 350         


Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
        355                 360                 365             


Val Glu Glu Asn Pro Gly Pro Met Pro Pro Pro Arg Leu Leu Phe Phe 
    370                 375                 380                 


Leu Leu Phe Leu Thr Pro Met Glu Val Arg Pro Glu Glu Pro Leu Val 
385                 390                 395                 400 


Val Lys Val Glu Glu Gly Asp Asn Ala Val Leu Gln Cys Leu Lys Gly 
                405                 410                 415     


Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr Trp Ser Arg Glu Ser Pro 
            420                 425                 430         


Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly Leu Pro Gly Leu Gly Ile 
        435                 440                 445             


His Met Arg Pro Leu Ala Ile Trp Leu Phe Ile Phe Asn Val Ser Gln 
    450                 455                 460                 


Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro Gly Pro Pro Ser Glu Lys 
465                 470                 475                 480 


Ala Trp Gln Pro Gly Trp Thr Val Asn Val Glu Gly Ser Gly Glu Leu 
                485                 490                 495     


Phe Arg Trp Asn Val Ser Asp Leu Gly Gly Leu Gly Cys Gly Leu Lys 
            500                 505                 510         


Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro Ser Gly Lys Leu Met Ser 
        515                 520                 525             


Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg Pro Glu Ile Trp Glu Gly 
    530                 535                 540                 


Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser Leu Asn Gln Ser Leu Ser 
545                 550                 555                 560 


Gln Asp Leu Thr Met Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly 
                565                 570                 575     


Val Pro Pro Asp Ser Val Ser Arg Gly Pro Leu Ser Trp Thr His Val 
            580                 585                 590         


His Pro Lys Gly Pro Lys Ser Leu Leu Ser Leu Glu Leu Lys Asp Asp 
        595                 600                 605             


Arg Pro Ala Arg Asp Met Trp Val Met Glu Thr Gly Leu Leu Leu Pro 
    610                 615                 620                 


Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr Tyr Cys His Arg Gly Asn 
625                 630                 635                 640 


Leu Thr Met Ser Phe His Leu Glu Ile Thr Ala Arg Pro Val Leu Trp 
                645                 650                 655     


His Trp Leu Leu Arg Thr Gly Gly Trp Lys Val Ser Ala Val Thr Leu 
            660                 665                 670         


Ala Tyr Leu Ile Phe Cys Leu Cys Ser Leu Val Gly Ile Leu His Leu 
        675                 680                 685             


Gln Arg Ala Leu Val Leu Arg Arg Lys Arg Lys Arg Met Thr 
    690                 695                 700         


<210>  179
<211>  703
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm5.38-CD28H-CD28TM-CD28CS-CD3zICS-T2A-trCD19

<400>  179

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asp 
        35                  40                  45              


Asp Asp Tyr Asp Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    50                  55                  60                  


Glu Gly Val Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Asp Phe Phe Arg Trp Asp Ser Gly Ser Tyr Tyr 
        115                 120                 125             


Val Arg Gly Cys Arg His Ala Thr Tyr Asp Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Gln Val Thr Val Ser Ser Val Lys Gly Lys His Leu Cys Pro Ser Pro 
145                 150                 155                 160 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
                165                 170                 175     


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
            180                 185                 190         


Phe Trp Val Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
        195                 200                 205             


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
    210                 215                 220                 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Leu Arg Val Lys Phe 
225                 230                 235                 240 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                245                 250                 255     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            260                 265                 270         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
        275                 280                 285             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    290                 295                 300                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
305                 310                 315                 320 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                325                 330                 335     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ala Arg Ala 
            340                 345                 350         


Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly 
        355                 360                 365             


Asp Val Glu Glu Asn Pro Gly Pro Met Pro Pro Pro Arg Leu Leu Phe 
    370                 375                 380                 


Phe Leu Leu Phe Leu Thr Pro Met Glu Val Arg Pro Glu Glu Pro Leu 
385                 390                 395                 400 


Val Val Lys Val Glu Glu Gly Asp Asn Ala Val Leu Gln Cys Leu Lys 
                405                 410                 415     


Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr Trp Ser Arg Glu Ser 
            420                 425                 430         


Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly Leu Pro Gly Leu Gly 
        435                 440                 445             


Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe Ile Phe Asn Val Ser 
    450                 455                 460                 


Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro Gly Pro Pro Ser Glu 
465                 470                 475                 480 


Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val Glu Gly Ser Gly Glu 
                485                 490                 495     


Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly Leu Gly Cys Gly Leu 
            500                 505                 510         


Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro Ser Gly Lys Leu Met 
        515                 520                 525             


Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg Pro Glu Ile Trp Glu 
    530                 535                 540                 


Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser Leu Asn Gln Ser Leu 
545                 550                 555                 560 


Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys 
                565                 570                 575     


Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro Leu Ser Trp Thr His 
            580                 585                 590         


Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser Leu Glu Leu Lys Asp 
        595                 600                 605             


Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu Thr Gly Leu Leu Leu 
    610                 615                 620                 


Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr Tyr Cys His Arg Gly 
625                 630                 635                 640 


Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr Ala Arg Pro Val Leu 
                645                 650                 655     


Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys Val Ser Ala Val Thr 
            660                 665                 670         


Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser Leu Val Gly Ile Leu His 
        675                 680                 685             


Leu Gln Arg Ala Leu Val Leu Arg Arg Lys Arg Lys Arg Met Thr 
    690                 695                 700             


<210>  180
<211>  819
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VHVL-CD28H-CD28TM-CD28CS-CD3zICS-T2A-trCD19

<400>  180

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg 
            20                  25                  30          


Pro Gly Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Gly Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
                165                 170                 175     


Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys 
        195                 200                 205             


Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His Pro Val Glu Glu Glu 
225                 230                 235                 240 


Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr 
                245                 250                 255     


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Ser Lys Arg Ser Arg Leu Leu His Ser 
305                 310                 315                 320 


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
                325                 330                 335     


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Leu 
            340                 345                 350         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        355                 360                 365             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    370                 375                 380                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
385                 390                 395                 400 


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                405                 410                 415     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            420                 425                 430         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        435                 440                 445             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 460                 


Arg Ala Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu 
465                 470                 475                 480 


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Pro Pro Pro 
                485                 490                 495     


Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met Glu Val Arg Pro 
            500                 505                 510         


Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val Leu 
        515                 520                 525             


Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr Trp 
    530                 535                 540                 


Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly Leu 
545                 550                 555                 560 


Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe Ile 
                565                 570                 575     


Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro Gly 
            580                 585                 590         


Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val Glu 
        595                 600                 605             


Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly Leu 
    610                 615                 620                 


Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro Ser 
625                 630                 635                 640 


Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg Pro 
                645                 650                 655     


Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser Leu 
            660                 665                 670         


Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr Leu 
        675                 680                 685             


Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro Leu 
    690                 695                 700                 


Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser Leu 
705                 710                 715                 720 


Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu Thr 
                725                 730                 735     


Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr Tyr 
            740                 745                 750         


Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr Ala 
        755                 760                 765             


Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys Val 
    770                 775                 780                 


Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser Leu Val 
785                 790                 795                 800 


Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg Arg Lys Arg Lys 
                805                 810                 815     


Arg Met Thr 
            


<210>  181
<211>  819
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VLVH-CD28H-CD28TM-CD28CS-CD3zICS-T2A-trCD19

<400>  181

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val 
        35                  40                  45              


Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly 
65                  70                  75                  80  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu 
                85                  90                  95      


Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly 
145                 150                 155                 160 


Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp 
                165                 170                 175     


Tyr Gly Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys 
        195                 200                 205             


Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Ser Lys Arg Ser Arg Leu Leu His Ser 
305                 310                 315                 320 


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
                325                 330                 335     


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Leu 
            340                 345                 350         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        355                 360                 365             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    370                 375                 380                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
385                 390                 395                 400 


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                405                 410                 415     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            420                 425                 430         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        435                 440                 445             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 460                 


Arg Ala Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu 
465                 470                 475                 480 


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Pro Pro Pro 
                485                 490                 495     


Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met Glu Val Arg Pro 
            500                 505                 510         


Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val Leu 
        515                 520                 525             


Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr Trp 
    530                 535                 540                 


Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly Leu 
545                 550                 555                 560 


Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe Ile 
                565                 570                 575     


Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro Gly 
            580                 585                 590         


Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val Glu 
        595                 600                 605             


Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly Leu 
    610                 615                 620                 


Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro Ser 
625                 630                 635                 640 


Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg Pro 
                645                 650                 655     


Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser Leu 
            660                 665                 670         


Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr Leu 
        675                 680                 685             


Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro Leu 
    690                 695                 700                 


Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser Leu 
705                 710                 715                 720 


Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu Thr 
                725                 730                 735     


Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr Tyr 
            740                 745                 750         


Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr Ala 
        755                 760                 765             


Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys Val 
    770                 775                 780                 


Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser Leu Val 
785                 790                 795                 800 


Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg Arg Lys Arg Lys 
                805                 810                 815     


Arg Met Thr 
            


<210>  182
<211>  819
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VHVL-CD28H-CD28TM-CD28CS-CD3zICS-T2A-trCD19

<400>  182

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg 
            20                  25                  30          


Pro Gly Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Gly Ile His Trp Val Lys Gln Ser His Ala Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
                165                 170                 175     


Ser Cys Arg Ala Asn Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys 
        195                 200                 205             


Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His Pro Val Glu Glu Glu 
225                 230                 235                 240 


Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr 
                245                 250                 255     


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Ser Lys Arg Ser Arg Leu Leu His Ser 
305                 310                 315                 320 


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
                325                 330                 335     


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Leu 
            340                 345                 350         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        355                 360                 365             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    370                 375                 380                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
385                 390                 395                 400 


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                405                 410                 415     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            420                 425                 430         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        435                 440                 445             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 460                 


Arg Ala Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu 
465                 470                 475                 480 


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Pro Pro Pro 
                485                 490                 495     


Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met Glu Val Arg Pro 
            500                 505                 510         


Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val Leu 
        515                 520                 525             


Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr Trp 
    530                 535                 540                 


Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly Leu 
545                 550                 555                 560 


Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe Ile 
                565                 570                 575     


Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro Gly 
            580                 585                 590         


Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val Glu 
        595                 600                 605             


Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly Leu 
    610                 615                 620                 


Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro Ser 
625                 630                 635                 640 


Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg Pro 
                645                 650                 655     


Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser Leu 
            660                 665                 670         


Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr Leu 
        675                 680                 685             


Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro Leu 
    690                 695                 700                 


Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser Leu 
705                 710                 715                 720 


Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu Thr 
                725                 730                 735     


Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr Tyr 
            740                 745                 750         


Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr Ala 
        755                 760                 765             


Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys Val 
    770                 775                 780                 


Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser Leu Val 
785                 790                 795                 800 


Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg Arg Lys Arg Lys 
                805                 810                 815     


Arg Met Thr 
            


<210>  183
<211>  819
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VLVH-CD28H-CD28TM-CD28CS-CD3zICS-T2A-trCD19

<400>  183

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Asn Lys Ser Val 
        35                  40                  45              


Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly 
65                  70                  75                  80  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu 
                85                  90                  95      


Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly 
145                 150                 155                 160 


Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp 
                165                 170                 175     


Tyr Gly Ile His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys 
        195                 200                 205             


Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Ser Lys Arg Ser Arg Leu Leu His Ser 
305                 310                 315                 320 


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
                325                 330                 335     


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Leu 
            340                 345                 350         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        355                 360                 365             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    370                 375                 380                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
385                 390                 395                 400 


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                405                 410                 415     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            420                 425                 430         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        435                 440                 445             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 460                 


Arg Ala Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu 
465                 470                 475                 480 


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Pro Pro Pro 
                485                 490                 495     


Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met Glu Val Arg Pro 
            500                 505                 510         


Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val Leu 
        515                 520                 525             


Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr Trp 
    530                 535                 540                 


Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly Leu 
545                 550                 555                 560 


Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe Ile 
                565                 570                 575     


Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro Gly 
            580                 585                 590         


Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val Glu 
        595                 600                 605             


Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly Leu 
    610                 615                 620                 


Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro Ser 
625                 630                 635                 640 


Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg Pro 
                645                 650                 655     


Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser Leu 
            660                 665                 670         


Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr Leu 
        675                 680                 685             


Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro Leu 
    690                 695                 700                 


Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser Leu 
705                 710                 715                 720 


Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu Thr 
                725                 730                 735     


Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr Tyr 
            740                 745                 750         


Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr Ala 
        755                 760                 765             


Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys Val 
    770                 775                 780                 


Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser Leu Val 
785                 790                 795                 800 


Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg Arg Lys Arg Lys 
                805                 810                 815     


Arg Met Thr 
            


<210>  184
<211>  704
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm22.84-CD28H-CD28TM-41BBCS-CD3zICS-T2A-trCD19

<400>  184

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
        35                  40                  45              


Ser Asn Tyr Val Asn Tyr Ala Met Gly Trp Phe Arg Gln Phe Pro Gly 
    50                  55                  60                  


Lys Glu Arg Glu Phe Val Ala Ser Ile Ser Trp Ser Ser Val Thr Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Ala His Leu Ala Gln Tyr Ser Asp Tyr 
        115                 120                 125             


Ala Tyr Arg Asp Pro His Gln Phe Gly Ala Trp Gly Gln Gly Thr Gln 
    130                 135                 140                 


Val Thr Val Ser Ser Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
145                 150                 155                 160 


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
                165                 170                 175     


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
            180                 185                 190         


Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        195                 200                 205             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    210                 215                 220                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Leu Arg Val Lys 
225                 230                 235                 240 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
                245                 250                 255     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            260                 265                 270         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
        275                 280                 285             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    290                 295                 300                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
305                 310                 315                 320 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                325                 330                 335     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ala Arg 
            340                 345                 350         


Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
        355                 360                 365             


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Pro Pro Pro Arg Leu Leu 
    370                 375                 380                 


Phe Phe Leu Leu Phe Leu Thr Pro Met Glu Val Arg Pro Glu Glu Pro 
385                 390                 395                 400 


Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val Leu Gln Cys Leu 
                405                 410                 415     


Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr Trp Ser Arg Glu 
            420                 425                 430         


Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly Leu Pro Gly Leu 
        435                 440                 445             


Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe Ile Phe Asn Val 
    450                 455                 460                 


Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro Gly Pro Pro Ser 
465                 470                 475                 480 


Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val Glu Gly Ser Gly 
                485                 490                 495     


Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly Leu Gly Cys Gly 
            500                 505                 510         


Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro Ser Gly Lys Leu 
        515                 520                 525             


Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg Pro Glu Ile Trp 
    530                 535                 540                 


Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser Leu Asn Gln Ser 
545                 550                 555                 560 


Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr Leu Trp Leu Ser 
                565                 570                 575     


Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro Leu Ser Trp Thr 
            580                 585                 590         


His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser Leu Glu Leu Lys 
        595                 600                 605             


Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu Thr Gly Leu Leu 
    610                 615                 620                 


Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr Tyr Cys His Arg 
625                 630                 635                 640 


Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr Ala Arg Pro Val 
                645                 650                 655     


Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys Val Ser Ala Val 
            660                 665                 670         


Thr Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser Leu Val Gly Ile Leu 
        675                 680                 685             


His Leu Gln Arg Ala Leu Val Leu Arg Arg Lys Arg Lys Arg Met Thr 
    690                 695                 700                 


<210>  185
<211>  705
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm5.38-CD28H-CD28TM-41BBCS-CD3zICS-T2A-trCD19

<400>  185

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asp 
        35                  40                  45              


Asp Asp Tyr Asp Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    50                  55                  60                  


Glu Gly Val Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Asp Phe Phe Arg Trp Asp Ser Gly Ser Tyr Tyr 
        115                 120                 125             


Val Arg Gly Cys Arg His Ala Thr Tyr Asp Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Gln Val Thr Val Ser Ser Val Lys Gly Lys His Leu Cys Pro Ser Pro 
145                 150                 155                 160 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
                165                 170                 175     


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
            180                 185                 190         


Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        195                 200                 205             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    210                 215                 220                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Leu Arg Val 
225                 230                 235                 240 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
                245                 250                 255     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            260                 265                 270         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln 
        275                 280                 285             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    290                 295                 300                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
305                 310                 315                 320 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                325                 330                 335     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ala 
            340                 345                 350         


Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr 
        355                 360                 365             


Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Pro Pro Pro Arg Leu 
    370                 375                 380                 


Leu Phe Phe Leu Leu Phe Leu Thr Pro Met Glu Val Arg Pro Glu Glu 
385                 390                 395                 400 


Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val Leu Gln Cys 
                405                 410                 415     


Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr Trp Ser Arg 
            420                 425                 430         


Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly Leu Pro Gly 
        435                 440                 445             


Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe Ile Phe Asn 
    450                 455                 460                 


Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro Gly Pro Pro 
465                 470                 475                 480 


Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val Glu Gly Ser 
                485                 490                 495     


Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly Leu Gly Cys 
            500                 505                 510         


Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro Ser Gly Lys 
        515                 520                 525             


Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg Pro Glu Ile 
    530                 535                 540                 


Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser Leu Asn Gln 
545                 550                 555                 560 


Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr Leu Trp Leu 
                565                 570                 575     


Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro Leu Ser Trp 
            580                 585                 590         


Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser Leu Glu Leu 
        595                 600                 605             


Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu Thr Gly Leu 
    610                 615                 620                 


Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr Tyr Cys His 
625                 630                 635                 640 


Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr Ala Arg Pro 
                645                 650                 655     


Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys Val Ser Ala 
            660                 665                 670         


Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser Leu Val Gly Ile 
        675                 680                 685             


Leu His Leu Gln Arg Ala Leu Val Leu Arg Arg Lys Arg Lys Arg Met 
    690                 695                 700                 


Thr 
705 


<210>  186
<211>  821
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VHVL-CD28H-CD28TM-41BBCS-CD3zICS-T2A-trCD19

<400>  186

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg 
            20                  25                  30          


Pro Gly Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Gly Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
                165                 170                 175     


Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys 
        195                 200                 205             


Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His Pro Val Glu Glu Glu 
225                 230                 235                 240 


Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr 
                245                 250                 255     


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
305                 310                 315                 320 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                325                 330                 335     


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            340                 345                 350         


Leu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
        355                 360                 365             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    370                 375                 380                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
385                 390                 395                 400 


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                405                 410                 415     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            420                 425                 430         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        435                 440                 445             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    450                 455                 460                 


Pro Pro Arg Ala Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly 
465                 470                 475                 480 


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Pro 
                485                 490                 495     


Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met Glu Val 
            500                 505                 510         


Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala 
        515                 520                 525             


Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu 
    530                 535                 540                 


Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu 
545                 550                 555                 560 


Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu 
                565                 570                 575     


Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln 
            580                 585                 590         


Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn 
        595                 600                 605             


Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly 
    610                 615                 620                 


Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser 
625                 630                 635                 640 


Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp 
                645                 650                 655     


Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp 
            660                 665                 670         


Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser 
        675                 680                 685             


Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly 
    690                 695                 700                 


Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu 
705                 710                 715                 720 


Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met 
                725                 730                 735     


Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys 
            740                 745                 750         


Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile 
        755                 760                 765             


Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp 
    770                 775                 780                 


Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser 
785                 790                 795                 800 


Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg Arg Lys 
                805                 810                 815     


Arg Lys Arg Met Thr 
            820     


<210>  187
<211>  821
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VLVH-CD28H-CD28TM-41BBCS-CD3zICS-T2A-trCD19

<400>  187

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val 
        35                  40                  45              


Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly 
65                  70                  75                  80  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu 
                85                  90                  95      


Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly 
145                 150                 155                 160 


Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp 
                165                 170                 175     


Tyr Gly Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys 
        195                 200                 205             


Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
305                 310                 315                 320 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                325                 330                 335     


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            340                 345                 350         


Leu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
        355                 360                 365             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    370                 375                 380                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
385                 390                 395                 400 


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                405                 410                 415     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            420                 425                 430         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        435                 440                 445             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    450                 455                 460                 


Pro Pro Arg Ala Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly 
465                 470                 475                 480 


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Pro 
                485                 490                 495     


Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met Glu Val 
            500                 505                 510         


Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala 
        515                 520                 525             


Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu 
    530                 535                 540                 


Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu 
545                 550                 555                 560 


Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu 
                565                 570                 575     


Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln 
            580                 585                 590         


Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn 
        595                 600                 605             


Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly 
    610                 615                 620                 


Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser 
625                 630                 635                 640 


Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp 
                645                 650                 655     


Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp 
            660                 665                 670         


Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser 
        675                 680                 685             


Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly 
    690                 695                 700                 


Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu 
705                 710                 715                 720 


Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met 
                725                 730                 735     


Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys 
            740                 745                 750         


Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile 
        755                 760                 765             


Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp 
    770                 775                 780                 


Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser 
785                 790                 795                 800 


Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg Arg Lys 
                805                 810                 815     


Arg Lys Arg Met Thr 
            820     


<210>  188
<211>  821
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VHVL-CD28H-CD28TM-41BBCS-CD3zICS-T2A-trCD19

<400>  188

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg 
            20                  25                  30          


Pro Gly Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Gly Ile His Trp Val Lys Gln Ser His Ala Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
                165                 170                 175     


Ser Cys Arg Ala Asn Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys 
        195                 200                 205             


Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His Pro Val Glu Glu Glu 
225                 230                 235                 240 


Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr 
                245                 250                 255     


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
305                 310                 315                 320 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                325                 330                 335     


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            340                 345                 350         


Leu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
        355                 360                 365             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    370                 375                 380                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
385                 390                 395                 400 


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                405                 410                 415     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            420                 425                 430         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        435                 440                 445             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    450                 455                 460                 


Pro Pro Arg Ala Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly 
465                 470                 475                 480 


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Pro 
                485                 490                 495     


Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met Glu Val 
            500                 505                 510         


Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala 
        515                 520                 525             


Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu 
    530                 535                 540                 


Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu 
545                 550                 555                 560 


Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu 
                565                 570                 575     


Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln 
            580                 585                 590         


Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn 
        595                 600                 605             


Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly 
    610                 615                 620                 


Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser 
625                 630                 635                 640 


Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp 
                645                 650                 655     


Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp 
            660                 665                 670         


Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser 
        675                 680                 685             


Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly 
    690                 695                 700                 


Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu 
705                 710                 715                 720 


Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met 
                725                 730                 735     


Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys 
            740                 745                 750         


Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile 
        755                 760                 765             


Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp 
    770                 775                 780                 


Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser 
785                 790                 795                 800 


Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg Arg Lys 
                805                 810                 815     


Arg Lys Arg Met Thr 
            820     


<210>  189
<211>  821
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VLVH-CD28H-CD28TM-41BBCS-CD3zICS-T2A-trCD19

<400>  189

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Asn Lys Ser Val 
        35                  40                  45              


Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly 
65                  70                  75                  80  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu 
                85                  90                  95      


Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly 
145                 150                 155                 160 


Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp 
                165                 170                 175     


Tyr Gly Ile His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys 
        195                 200                 205             


Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
305                 310                 315                 320 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                325                 330                 335     


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            340                 345                 350         


Leu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
        355                 360                 365             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    370                 375                 380                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
385                 390                 395                 400 


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                405                 410                 415     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            420                 425                 430         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        435                 440                 445             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    450                 455                 460                 


Pro Pro Arg Ala Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly 
465                 470                 475                 480 


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Pro 
                485                 490                 495     


Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met Glu Val 
            500                 505                 510         


Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala 
        515                 520                 525             


Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu 
    530                 535                 540                 


Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu 
545                 550                 555                 560 


Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu 
                565                 570                 575     


Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln 
            580                 585                 590         


Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn 
        595                 600                 605             


Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly 
    610                 615                 620                 


Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser 
625                 630                 635                 640 


Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp 
                645                 650                 655     


Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp 
            660                 665                 670         


Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser 
        675                 680                 685             


Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly 
    690                 695                 700                 


Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu 
705                 710                 715                 720 


Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met 
                725                 730                 735     


Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys 
            740                 745                 750         


Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile 
        755                 760                 765             


Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp 
    770                 775                 780                 


Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser 
785                 790                 795                 800 


Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg Arg Lys 
                805                 810                 815     


Arg Lys Arg Met Thr 
            820     


<210>  190
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm22.84-CD28H-CD28TM-DAP10CS-CD3zICS-T2A-trCD19

<400>  190

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
        35                  40                  45              


Ser Asn Tyr Val Asn Tyr Ala Met Gly Trp Phe Arg Gln Phe Pro Gly 
    50                  55                  60                  


Lys Glu Arg Glu Phe Val Ala Ser Ile Ser Trp Ser Ser Val Thr Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Ala His Leu Ala Gln Tyr Ser Asp Tyr 
        115                 120                 125             


Ala Tyr Arg Asp Pro His Gln Phe Gly Ala Trp Gly Gln Gly Thr Gln 
    130                 135                 140                 


Val Thr Val Ser Ser Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
145                 150                 155                 160 


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
                165                 170                 175     


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
            180                 185                 190         


Trp Val Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly 
        195                 200                 205             


Lys Val Tyr Ile Asn Met Pro Gly Arg Gly Leu Arg Val Lys Phe Ser 
    210                 215                 220                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
225                 230                 235                 240 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                245                 250                 255     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
            260                 265                 270         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        275                 280                 285             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    290                 295                 300                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
305                 310                 315                 320 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ala Arg Ala Lys 
                325                 330                 335     


Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
            340                 345                 350         


Val Glu Glu Asn Pro Gly Pro Met Pro Pro Pro Arg Leu Leu Phe Phe 
        355                 360                 365             


Leu Leu Phe Leu Thr Pro Met Glu Val Arg Pro Glu Glu Pro Leu Val 
    370                 375                 380                 


Val Lys Val Glu Glu Gly Asp Asn Ala Val Leu Gln Cys Leu Lys Gly 
385                 390                 395                 400 


Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr Trp Ser Arg Glu Ser Pro 
                405                 410                 415     


Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly Leu Pro Gly Leu Gly Ile 
            420                 425                 430         


His Met Arg Pro Leu Ala Ile Trp Leu Phe Ile Phe Asn Val Ser Gln 
        435                 440                 445             


Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro Gly Pro Pro Ser Glu Lys 
    450                 455                 460                 


Ala Trp Gln Pro Gly Trp Thr Val Asn Val Glu Gly Ser Gly Glu Leu 
465                 470                 475                 480 


Phe Arg Trp Asn Val Ser Asp Leu Gly Gly Leu Gly Cys Gly Leu Lys 
                485                 490                 495     


Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro Ser Gly Lys Leu Met Ser 
            500                 505                 510         


Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg Pro Glu Ile Trp Glu Gly 
        515                 520                 525             


Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser Leu Asn Gln Ser Leu Ser 
    530                 535                 540                 


Gln Asp Leu Thr Met Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly 
545                 550                 555                 560 


Val Pro Pro Asp Ser Val Ser Arg Gly Pro Leu Ser Trp Thr His Val 
                565                 570                 575     


His Pro Lys Gly Pro Lys Ser Leu Leu Ser Leu Glu Leu Lys Asp Asp 
            580                 585                 590         


Arg Pro Ala Arg Asp Met Trp Val Met Glu Thr Gly Leu Leu Leu Pro 
        595                 600                 605             


Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr Tyr Cys His Arg Gly Asn 
    610                 615                 620                 


Leu Thr Met Ser Phe His Leu Glu Ile Thr Ala Arg Pro Val Leu Trp 
625                 630                 635                 640 


His Trp Leu Leu Arg Thr Gly Gly Trp Lys Val Ser Ala Val Thr Leu 
                645                 650                 655     


Ala Tyr Leu Ile Phe Cys Leu Cys Ser Leu Val Gly Ile Leu His Leu 
            660                 665                 670         


Gln Arg Ala Leu Val Leu Arg Arg Lys Arg Lys Arg Met Thr 
        675                 680                 685     


<210>  191
<211>  687
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm5.38-CD28H-CD28TM-DAP10CS-CD3zICS-T2A-trCD19

<400>  191

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asp 
        35                  40                  45              


Asp Asp Tyr Asp Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    50                  55                  60                  


Glu Gly Val Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Asp Phe Phe Arg Trp Asp Ser Gly Ser Tyr Tyr 
        115                 120                 125             


Val Arg Gly Cys Arg His Ala Thr Tyr Asp Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Gln Val Thr Val Ser Ser Val Lys Gly Lys His Leu Cys Pro Ser Pro 
145                 150                 155                 160 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
                165                 170                 175     


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
            180                 185                 190         


Phe Trp Val Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp 
        195                 200                 205             


Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly Leu Arg Val Lys Phe 
    210                 215                 220                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
225                 230                 235                 240 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                245                 250                 255     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
            260                 265                 270         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        275                 280                 285             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    290                 295                 300                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
305                 310                 315                 320 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ala Arg Ala 
                325                 330                 335     


Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly 
            340                 345                 350         


Asp Val Glu Glu Asn Pro Gly Pro Met Pro Pro Pro Arg Leu Leu Phe 
        355                 360                 365             


Phe Leu Leu Phe Leu Thr Pro Met Glu Val Arg Pro Glu Glu Pro Leu 
    370                 375                 380                 


Val Val Lys Val Glu Glu Gly Asp Asn Ala Val Leu Gln Cys Leu Lys 
385                 390                 395                 400 


Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr Trp Ser Arg Glu Ser 
                405                 410                 415     


Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly Leu Pro Gly Leu Gly 
            420                 425                 430         


Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe Ile Phe Asn Val Ser 
        435                 440                 445             


Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro Gly Pro Pro Ser Glu 
    450                 455                 460                 


Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val Glu Gly Ser Gly Glu 
465                 470                 475                 480 


Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly Leu Gly Cys Gly Leu 
                485                 490                 495     


Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro Ser Gly Lys Leu Met 
            500                 505                 510         


Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg Pro Glu Ile Trp Glu 
        515                 520                 525             


Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser Leu Asn Gln Ser Leu 
    530                 535                 540                 


Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys 
545                 550                 555                 560 


Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro Leu Ser Trp Thr His 
                565                 570                 575     


Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser Leu Glu Leu Lys Asp 
            580                 585                 590         


Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu Thr Gly Leu Leu Leu 
        595                 600                 605             


Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr Tyr Cys His Arg Gly 
    610                 615                 620                 


Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr Ala Arg Pro Val Leu 
625                 630                 635                 640 


Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys Val Ser Ala Val Thr 
                645                 650                 655     


Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser Leu Val Gly Ile Leu His 
            660                 665                 670         


Leu Gln Arg Ala Leu Val Leu Arg Arg Lys Arg Lys Arg Met Thr 
        675                 680                 685         


<210>  192
<211>  803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VHVL-CD28H-CD28TM-DAP10CS-CD3zICS-T2A-trCD19

<400>  192

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg 
            20                  25                  30          


Pro Gly Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Gly Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
                165                 170                 175     


Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys 
        195                 200                 205             


Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His Pro Val Glu Glu Glu 
225                 230                 235                 240 


Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr 
                245                 250                 255     


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Leu Cys Ala Arg Pro Arg Arg Ser Pro 
305                 310                 315                 320 


Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly Leu 
                325                 330                 335     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
            340                 345                 350         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        355                 360                 365             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    370                 375                 380                 


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
385                 390                 395                 400 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                405                 410                 415     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            420                 425                 430         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        435                 440                 445             


Arg Ala Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu 
    450                 455                 460                 


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Pro Pro Pro 
465                 470                 475                 480 


Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met Glu Val Arg Pro 
                485                 490                 495     


Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val Leu 
            500                 505                 510         


Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr Trp 
        515                 520                 525             


Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly Leu 
    530                 535                 540                 


Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe Ile 
545                 550                 555                 560 


Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro Gly 
                565                 570                 575     


Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val Glu 
            580                 585                 590         


Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly Leu 
        595                 600                 605             


Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro Ser 
    610                 615                 620                 


Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg Pro 
625                 630                 635                 640 


Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser Leu 
                645                 650                 655     


Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr Leu 
            660                 665                 670         


Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro Leu 
        675                 680                 685             


Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser Leu 
    690                 695                 700                 


Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu Thr 
705                 710                 715                 720 


Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr Tyr 
                725                 730                 735     


Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr Ala 
            740                 745                 750         


Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys Val 
        755                 760                 765             


Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser Leu Val 
    770                 775                 780                 


Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg Arg Lys Arg Lys 
785                 790                 795                 800 


Arg Met Thr 
            


<210>  193
<211>  803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VLVH-CD28H-CD28TM-DAP10CS-CD3zICS-T2A-trCD19

<400>  193

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val 
        35                  40                  45              


Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly 
65                  70                  75                  80  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu 
                85                  90                  95      


Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly 
145                 150                 155                 160 


Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp 
                165                 170                 175     


Tyr Gly Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys 
        195                 200                 205             


Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Leu Cys Ala Arg Pro Arg Arg Ser Pro 
305                 310                 315                 320 


Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly Leu 
                325                 330                 335     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
            340                 345                 350         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        355                 360                 365             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    370                 375                 380                 


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
385                 390                 395                 400 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                405                 410                 415     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            420                 425                 430         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        435                 440                 445             


Arg Ala Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu 
    450                 455                 460                 


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Pro Pro Pro 
465                 470                 475                 480 


Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met Glu Val Arg Pro 
                485                 490                 495     


Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val Leu 
            500                 505                 510         


Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr Trp 
        515                 520                 525             


Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly Leu 
    530                 535                 540                 


Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe Ile 
545                 550                 555                 560 


Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro Gly 
                565                 570                 575     


Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val Glu 
            580                 585                 590         


Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly Leu 
        595                 600                 605             


Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro Ser 
    610                 615                 620                 


Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg Pro 
625                 630                 635                 640 


Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser Leu 
                645                 650                 655     


Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr Leu 
            660                 665                 670         


Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro Leu 
        675                 680                 685             


Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser Leu 
    690                 695                 700                 


Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu Thr 
705                 710                 715                 720 


Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr Tyr 
                725                 730                 735     


Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr Ala 
            740                 745                 750         


Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys Val 
        755                 760                 765             


Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser Leu Val 
    770                 775                 780                 


Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg Arg Lys Arg Lys 
785                 790                 795                 800 


Arg Met Thr 
            


<210>  194
<211>  803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VHVL-CD28H-CD28TM-DAP10CS-CD3zICS-T2A-trCD19

<400>  194

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg 
            20                  25                  30          


Pro Gly Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Gly Ile His Trp Val Lys Gln Ser His Ala Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
                165                 170                 175     


Ser Cys Arg Ala Asn Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys 
        195                 200                 205             


Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His Pro Val Glu Glu Glu 
225                 230                 235                 240 


Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr 
                245                 250                 255     


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Leu Cys Ala Arg Pro Arg Arg Ser Pro 
305                 310                 315                 320 


Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly Leu 
                325                 330                 335     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
            340                 345                 350         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        355                 360                 365             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    370                 375                 380                 


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
385                 390                 395                 400 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                405                 410                 415     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            420                 425                 430         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        435                 440                 445             


Arg Ala Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu 
    450                 455                 460                 


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Pro Pro Pro 
465                 470                 475                 480 


Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met Glu Val Arg Pro 
                485                 490                 495     


Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val Leu 
            500                 505                 510         


Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr Trp 
        515                 520                 525             


Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly Leu 
    530                 535                 540                 


Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe Ile 
545                 550                 555                 560 


Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro Gly 
                565                 570                 575     


Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val Glu 
            580                 585                 590         


Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly Leu 
        595                 600                 605             


Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro Ser 
    610                 615                 620                 


Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg Pro 
625                 630                 635                 640 


Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser Leu 
                645                 650                 655     


Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr Leu 
            660                 665                 670         


Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro Leu 
        675                 680                 685             


Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser Leu 
    690                 695                 700                 


Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu Thr 
705                 710                 715                 720 


Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr Tyr 
                725                 730                 735     


Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr Ala 
            740                 745                 750         


Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys Val 
        755                 760                 765             


Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser Leu Val 
    770                 775                 780                 


Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg Arg Lys Arg Lys 
785                 790                 795                 800 


Arg Met Thr 
            


<210>  195
<211>  803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VLVH-CD28H-CD28TM-DAP10CS-CD3zICS-T2A-trCD19

<400>  195

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Asn Lys Ser Val 
        35                  40                  45              


Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly 
65                  70                  75                  80  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu 
                85                  90                  95      


Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly 
145                 150                 155                 160 


Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp 
                165                 170                 175     


Tyr Gly Ile His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys 
        195                 200                 205             


Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Leu Cys Ala Arg Pro Arg Arg Ser Pro 
305                 310                 315                 320 


Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly Leu 
                325                 330                 335     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
            340                 345                 350         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        355                 360                 365             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    370                 375                 380                 


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
385                 390                 395                 400 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                405                 410                 415     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            420                 425                 430         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        435                 440                 445             


Arg Ala Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu 
    450                 455                 460                 


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Pro Pro Pro 
465                 470                 475                 480 


Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met Glu Val Arg Pro 
                485                 490                 495     


Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val Leu 
            500                 505                 510         


Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr Trp 
        515                 520                 525             


Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly Leu 
    530                 535                 540                 


Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe Ile 
545                 550                 555                 560 


Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro Gly 
                565                 570                 575     


Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val Glu 
            580                 585                 590         


Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly Leu 
        595                 600                 605             


Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro Ser 
    610                 615                 620                 


Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg Pro 
625                 630                 635                 640 


Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser Leu 
                645                 650                 655     


Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr Leu 
            660                 665                 670         


Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro Leu 
        675                 680                 685             


Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser Leu 
    690                 695                 700                 


Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu Thr 
705                 710                 715                 720 


Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr Tyr 
                725                 730                 735     


Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr Ala 
            740                 745                 750         


Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys Val 
        755                 760                 765             


Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser Leu Val 
    770                 775                 780                 


Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg Arg Lys Arg Lys 
785                 790                 795                 800 


Arg Met Thr 
            


<210>  196
<211>  756
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3zICS-CD28CS-TWEAK-T2A-trCD19

<400>  196

Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    50                  55                  60                  


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
65                  70                  75                  80  


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                85                  90                  95      


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            100                 105                 110         


Pro Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
        115                 120                 125             


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
    130                 135                 140                 


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Ala Ala Arg Arg Ser Gln 
145                 150                 155                 160 


Arg Arg Arg Gly Arg Arg Gly Glu Pro Gly Thr Ala Leu Leu Val Pro 
                165                 170                 175     


Leu Ala Leu Gly Leu Gly Leu Ala Leu Ala Cys Leu Gly Leu Leu Leu 
            180                 185                 190         


Ala Val Val Ser Leu Gly Ser Arg Ala Ser Leu Ser Ala Gln Glu Pro 
        195                 200                 205             


Ala Gln Glu Glu Leu Val Ala Glu Glu Asp Gln Asp Pro Ser Glu Leu 
    210                 215                 220                 


Asn Pro Gln Thr Glu Glu Ser Gln Asp Pro Ala Pro Phe Leu Asn Arg 
225                 230                 235                 240 


Leu Val Arg Pro Arg Arg Ser Ala Pro Lys Gly Arg Lys Thr Arg Ala 
                245                 250                 255     


Arg Arg Ala Ile Ala Ala His Tyr Glu Val His Pro Arg Pro Gly Gln 
            260                 265                 270         


Asp Gly Ala Gln Ala Gly Val Asp Gly Thr Val Ser Gly Trp Glu Glu 
        275                 280                 285             


Ala Arg Ile Asn Ser Ser Ser Pro Leu Arg Tyr Asn Arg Gln Ile Gly 
    290                 295                 300                 


Glu Phe Ile Val Thr Arg Ala Gly Leu Tyr Tyr Leu Tyr Cys Gln Val 
305                 310                 315                 320 


His Phe Asp Glu Gly Lys Ala Val Tyr Leu Lys Leu Asp Leu Leu Val 
                325                 330                 335     


Asp Gly Val Leu Ala Leu Arg Cys Leu Glu Glu Phe Ser Ala Thr Ala 
            340                 345                 350         


Ala Ser Ser Leu Gly Pro Gln Leu Arg Leu Cys Gln Val Ser Gly Leu 
        355                 360                 365             


Leu Ala Leu Arg Pro Gly Ser Ser Leu Arg Ile Arg Thr Leu Pro Trp 
    370                 375                 380                 


Ala His Leu Lys Ala Ala Pro Phe Leu Thr Tyr Phe Gly Leu Phe Gln 
385                 390                 395                 400 


Val His Ala Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser 
                405                 410                 415     


Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Pro Pro 
            420                 425                 430         


Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met Glu Val Arg 
        435                 440                 445             


Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val 
    450                 455                 460                 


Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr 
465                 470                 475                 480 


Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly 
                485                 490                 495     


Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe 
            500                 505                 510         


Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro 
        515                 520                 525             


Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val 
    530                 535                 540                 


Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly 
545                 550                 555                 560 


Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro 
                565                 570                 575     


Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg 
            580                 585                 590         


Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser 
        595                 600                 605             


Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr 
    610                 615                 620                 


Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro 
625                 630                 635                 640 


Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser 
                645                 650                 655     


Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu 
            660                 665                 670         


Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr 
        675                 680                 685             


Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr 
    690                 695                 700                 


Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys 
705                 710                 715                 720 


Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser Leu 
                725                 730                 735     


Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg Arg Lys Arg 
            740                 745                 750         


Lys Arg Met Thr 
        755     


<210>  197
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3zICS-41BBCS -TWEAK-T2A-trCD19

<400>  197

Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    50                  55                  60                  


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
65                  70                  75                  80  


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                85                  90                  95      


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            100                 105                 110         


Pro Arg Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        115                 120                 125             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    130                 135                 140                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Ala Ala Arg Arg 
145                 150                 155                 160 


Ser Gln Arg Arg Arg Gly Arg Arg Gly Glu Pro Gly Thr Ala Leu Leu 
                165                 170                 175     


Val Pro Leu Ala Leu Gly Leu Gly Leu Ala Leu Ala Cys Leu Gly Leu 
            180                 185                 190         


Leu Leu Ala Val Val Ser Leu Gly Ser Arg Ala Ser Leu Ser Ala Gln 
        195                 200                 205             


Glu Pro Ala Gln Glu Glu Leu Val Ala Glu Glu Asp Gln Asp Pro Ser 
    210                 215                 220                 


Glu Leu Asn Pro Gln Thr Glu Glu Ser Gln Asp Pro Ala Pro Phe Leu 
225                 230                 235                 240 


Asn Arg Leu Val Arg Pro Arg Arg Ser Ala Pro Lys Gly Arg Lys Thr 
                245                 250                 255     


Arg Ala Arg Arg Ala Ile Ala Ala His Tyr Glu Val His Pro Arg Pro 
            260                 265                 270         


Gly Gln Asp Gly Ala Gln Ala Gly Val Asp Gly Thr Val Ser Gly Trp 
        275                 280                 285             


Glu Glu Ala Arg Ile Asn Ser Ser Ser Pro Leu Arg Tyr Asn Arg Gln 
    290                 295                 300                 


Ile Gly Glu Phe Ile Val Thr Arg Ala Gly Leu Tyr Tyr Leu Tyr Cys 
305                 310                 315                 320 


Gln Val His Phe Asp Glu Gly Lys Ala Val Tyr Leu Lys Leu Asp Leu 
                325                 330                 335     


Leu Val Asp Gly Val Leu Ala Leu Arg Cys Leu Glu Glu Phe Ser Ala 
            340                 345                 350         


Thr Ala Ala Ser Ser Leu Gly Pro Gln Leu Arg Leu Cys Gln Val Ser 
        355                 360                 365             


Gly Leu Leu Ala Leu Arg Pro Gly Ser Ser Leu Arg Ile Arg Thr Leu 
    370                 375                 380                 


Pro Trp Ala His Leu Lys Ala Ala Pro Phe Leu Thr Tyr Phe Gly Leu 
385                 390                 395                 400 


Phe Gln Val His Ala Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg 
                405                 410                 415     


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
            420                 425                 430         


Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met Glu 
        435                 440                 445             


Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn 
    450                 455                 460                 


Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln 
465                 470                 475                 480 


Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser 
                485                 490                 495     


Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp 
            500                 505                 510         


Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys 
        515                 520                 525             


Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val 
    530                 535                 540                 


Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu 
545                 550                 555                 560 


Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser 
                565                 570                 575     


Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys 
            580                 585                 590         


Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg 
        595                 600                 605             


Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly 
    610                 615                 620                 


Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg 
625                 630                 635                 640 


Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu 
                645                 650                 655     


Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val 
            660                 665                 670         


Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly 
        675                 680                 685             


Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu 
    690                 695                 700                 


Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly 
705                 710                 715                 720 


Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu Cys 
                725                 730                 735     


Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg Arg 
            740                 745                 750         


Lys Arg Lys Arg Met Thr 
        755             


<210>  198
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3zICS-DAP10CS-TWEAK-T2A-trCD19

<400>  198

Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    50                  55                  60                  


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
65                  70                  75                  80  


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                85                  90                  95      


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            100                 105                 110         


Pro Arg Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly 
        115                 120                 125             


Lys Val Tyr Ile Asn Met Pro Gly Arg Gly Ala Ala Arg Arg Ser Gln 
    130                 135                 140                 


Arg Arg Arg Gly Arg Arg Gly Glu Pro Gly Thr Ala Leu Leu Val Pro 
145                 150                 155                 160 


Leu Ala Leu Gly Leu Gly Leu Ala Leu Ala Cys Leu Gly Leu Leu Leu 
                165                 170                 175     


Ala Val Val Ser Leu Gly Ser Arg Ala Ser Leu Ser Ala Gln Glu Pro 
            180                 185                 190         


Ala Gln Glu Glu Leu Val Ala Glu Glu Asp Gln Asp Pro Ser Glu Leu 
        195                 200                 205             


Asn Pro Gln Thr Glu Glu Ser Gln Asp Pro Ala Pro Phe Leu Asn Arg 
    210                 215                 220                 


Leu Val Arg Pro Arg Arg Ser Ala Pro Lys Gly Arg Lys Thr Arg Ala 
225                 230                 235                 240 


Arg Arg Ala Ile Ala Ala His Tyr Glu Val His Pro Arg Pro Gly Gln 
                245                 250                 255     


Asp Gly Ala Gln Ala Gly Val Asp Gly Thr Val Ser Gly Trp Glu Glu 
            260                 265                 270         


Ala Arg Ile Asn Ser Ser Ser Pro Leu Arg Tyr Asn Arg Gln Ile Gly 
        275                 280                 285             


Glu Phe Ile Val Thr Arg Ala Gly Leu Tyr Tyr Leu Tyr Cys Gln Val 
    290                 295                 300                 


His Phe Asp Glu Gly Lys Ala Val Tyr Leu Lys Leu Asp Leu Leu Val 
305                 310                 315                 320 


Asp Gly Val Leu Ala Leu Arg Cys Leu Glu Glu Phe Ser Ala Thr Ala 
                325                 330                 335     


Ala Ser Ser Leu Gly Pro Gln Leu Arg Leu Cys Gln Val Ser Gly Leu 
            340                 345                 350         


Leu Ala Leu Arg Pro Gly Ser Ser Leu Arg Ile Arg Thr Leu Pro Trp 
        355                 360                 365             


Ala His Leu Lys Ala Ala Pro Phe Leu Thr Tyr Phe Gly Leu Phe Gln 
    370                 375                 380                 


Val His Ala Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser 
385                 390                 395                 400 


Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Pro Pro 
                405                 410                 415     


Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met Glu Val Arg 
            420                 425                 430         


Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val 
        435                 440                 445             


Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr 
    450                 455                 460                 


Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly 
465                 470                 475                 480 


Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe 
                485                 490                 495     


Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro 
            500                 505                 510         


Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val 
        515                 520                 525             


Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly 
    530                 535                 540                 


Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro 
545                 550                 555                 560 


Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg 
                565                 570                 575     


Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser 
            580                 585                 590         


Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr 
        595                 600                 605             


Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro 
    610                 615                 620                 


Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser 
625                 630                 635                 640 


Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu 
                645                 650                 655     


Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr 
            660                 665                 670         


Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr 
        675                 680                 685             


Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys 
    690                 695                 700                 


Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser Leu 
705                 710                 715                 720 


Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg Arg Lys Arg 
                725                 730                 735     


Lys Arg Met Thr 
            740 


<210> 199

<400> 199
000

<210> 200

<400> 200
000

<210> 201

<400> 201
000

<210> 202

<400> 202
000

<210> 203

<400> 203
000

<210> 204

<400> 204
000


<210>  205
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader sequence

<400>  205
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagc          57



<210> 206

<400> 206
000

<210> 207

<400> 207
000

<210> 208

<400> 208
000

<210> 209

<400> 209
000


<210>  210
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD206 nanobody NbMMRm22.84

<400>  210
caggttcagc tgcaagagtc tggcggagga ctggttcaac ctggcggaag cctgagactg       60

tcttgtgccg cttctggcag aaccttcagc aactacgtga actacgccat gggctggttc      120

agacagttcc ccggcaaaga gagagagttc gtcgccagca tcagctggtc tagcgtgacc      180

acctactacg ccgacagcgt gaagggcaga ttcaccatca gcagagacaa cgccaagaac      240

accgtgtacc tgcagatgaa cagcctgaag ccagaggaca ccgccgtgta ctactgtgct      300

gctcacctgg ctcagtacag cgactacgcc tacagagatc cccaccagtt tggcgcttgg      360

ggccagggaa cacaagtgac cgttagctct                                       390



<210> 211

<400> 211
000

<210> 212

<400> 212
000

<210> 213

<400> 213
000


<210>  214
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD206 nanobody NbMMRm5.38

<400>  214
caggttcagc tgcaagagtc tggcggagga ctggttcaag ctggcggaag cctgagactg       60

tcttgtgccg cttctggctt caccgacgac gactacgata tcggctggtt cagacaggcc      120

cctggcaaag agagagaggg cgtcagctgt atcagcagct ctgacggctc tacctactac      180

gccgacagcg tgaagggcag attcaccatc agcagcgaca acgccaagaa caccgtgtac      240

ctgcagatga actctctgaa gcccgaggac accgccgtgt actactgtgc cgccgacttc      300

ttcagatggg acagcggcag ctactacgtg cggggatgta gacacgccac ctacgattac      360

tggggccagg gcacacaagt gaccgtgtca tct                                   393


<210> 215

<400> 215
000

<210> 216

<400> 216
000

<210> 217

<400> 217
000


<210>  218
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 antibody AbP4A8 heavy chain variable domain (P4A8VH)

<400>  218
caggtccagc tgcagcagtc tgggcctgag gtggtgaggc ctggggtctc agtgaagatt       60

tcctgcaagg gttccggcta cacattcact gattatggta tgcactgggt gaagcagagt      120

catgcaaaga gtctagagtg gattggagtt attagtactt acaatggtta tacaaactac      180

aaccagaagt ttaagggcaa ggccacaatg actgtagaca aatcctccag cacagcctat      240

atggaacttg ccagattgac atctgaggat tctgccatct attactgtgc aagagcctac      300

tatggtaacc tttactatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210> 219

<400> 219
000

<210> 220

<400> 220
000

<210> 221

<400> 221
000


<210>  222
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 antibody AbP4A8 light chain variable domain (P4A8VL)

<400>  222
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt acatctagct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcatcct caacatccat      240

ccagtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttccattc      300

acgttcggct cggggacaaa gttggaaata aaa                                   333



<210> 223

<400> 223
000

<210> 224

<400> 224
000

<210> 225

<400> 225
000


<210>  226
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 antibody AbP3G5 heavy chain variable domain (P3G5VH)

<400>  226
caggtccagc tgcagcagtc tgggcctgag gtggtgaggc ctggggtctc agtgaagatt       60

tcctgcaagg gttccggcta cacattcact gattatggta tacactgggt gaagcagagt      120

catgcaaaga gtctagagtg gattggagtt attagtactt acaatggtta tacaaactac      180

aaccagaagt ttaagggcaa ggccacaatg actgtagaca aatcctccag cacagcctat      240

atggaacttg ccagattgac atctgaggat tctgccatct attactgtgc aagagcctac      300

tatggtaacc tttactatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210> 227

<400> 227
000

<210> 228

<400> 228
000

<210> 229

<400> 229
000


<210>  230
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 antibody AbP3G5 light chain variable domain (P3G5VL)

<400>  230
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccaacaa aagtgtcagt acatctagct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcatcct caacatccat      240

ccagtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttccattc      300

acgttcggct cggggacaaa gttggaaata aaa                                   333


<210> 231

<400> 231
000

<210> 232

<400> 232
000

<210> 233

<400> 233
000


<210>  234
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human TWEAK (without Met/ATG)

<400>  234
gccgcccgtc ggagccagag gcggaggggg cgccgggggg agccgggcac cgccctgctg       60

gtcccgctcg cgctgggcct gggcctggcg ctggcctgcc tcggcctcct gctggccgtg      120

gtcagtttgg ggagccgggc atcgctgtcc gcccaggagc ctgcccagga ggagctggtg      180

gcagaggagg accaggaccc gtcggaactg aatccccaga cagaagaaag ccaggatcct      240

gcgcctttcc tgaaccgact agttcggcct cgcagaagtg cacctaaagg ccggaaaaca      300

cgggctcgaa gagcgatcgc agcccattat gaagttcatc cacgacctgg acaggacgga      360

gcgcaggcag gtgtggacgg gacagtgagt ggctgggagg aagccagaat caacagctcc      420

agccctctgc gctacaaccg ccagatcggg gagtttatag tcacccgggc tgggctctac      480

tacctgtact gtcaggtgca ctttgatgag gggaaggctg tctacctgaa gctggacttg      540

ctggtggatg gtgtgctggc cctgcgctgc ctggaggaat tctcagccac tgcggccagt      600

tccctcgggc cccagctccg cctctgccag gtgtctgggc tgttggccct gcggccaggg      660

tcctccctgc ggatccgcac cctcccctgg gcccatctca aggctgcccc cttcctcacc      720

tacttcggac tcttccaggt tcactga                                          747


<210>  235
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse TWEAK (without Met/ATG)

<400>  235
gccgcccgtc ggagccagag gcggaggggg cgccgggggg agccgggcac cgccctgctg       60

gccccgctgg tgctgagcct gggcctggcg ctggcctgcc ttggcctcct gctggtcgtg      120

gtcagcctgg ggagctgggc aacgctgtct gcccaggagc cttctcagga ggagctgaca      180

gcagaggacc gccgggagcc ccctgaactg aatccccaga cagaggaaag ccaggatgtg      240

gtacctttct tggaacaact agtccggcct cgaagaagtg ctcctaaagg ccggaaggcg      300

cggcctcgcc gagctattgc agcccattat gaggttcatc ctcggccagg acaggatgga      360

gcacaagcag gtgtggatgg gacagtgagt ggctgggaag agaccaaaat caacagctcc      420

agccctctgc gctacgaccg ccagattggg gaatttacag tcatcagggc tgggctctac      480

tacctgtact gtcaggtgca ctttgatgag ggaaaggctg tctacctgaa gctggacttg      540

ctggtgaacg gtgtgctggc cctgcgctgc ctggaagaat tctcagccac agcagcaagc      600

tctcctgggc cccagctccg tttgtgccag gtgtctgggc tgttgccgct gcggccaggg      660

tcttcccttc ggatccgcac cctcccctgg gctcatctta aggctgcccc cttcctaacc      720

tactttggac tctttcaagt tcactga                                          747


<210>  236
<211>  1212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3zICS-CD28CS-TWEAK

<400>  236
cttagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag       60

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt      120

ggccgggacc ctgagatggg gggaaagccg cagagaagga agaaccctca ggaaggcctg      180

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc      240

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag      300

gacacctacg acgcccttca catgcaggcc ctgccccctc gcaggagtaa gaggagcagg      360

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat      420

taccagccct atgccccacc acgcgacttc gcagcctatc gctccgccgc ccgtcggagc      480

cagaggcgga gggggcgccg gggggagccg ggcaccgccc tgctggtccc gctcgcgctg      540

ggcctgggcc tggcgctggc ctgcctcggc ctcctgctgg ccgtggtcag tttggggagc      600

cgggcatcgc tgtccgccca ggagcctgcc caggaggagc tggtggcaga ggaggaccag      660

gacccgtcgg aactgaatcc ccagacagaa gaaagccagg atcctgcgcc tttcctgaac      720

cgactagttc ggcctcgcag aagtgcacct aaaggccgga aaacacgggc tcgaagagcg      780

atcgcagccc attatgaagt tcatccacga cctggacagg acggagcgca ggcaggtgtg      840

gacgggacag tgagtggctg ggaggaagcc agaatcaaca gctccagccc tctgcgctac      900

aaccgccaga tcggggagtt tatagtcacc cgggctgggc tctactacct gtactgtcag      960

gtgcactttg atgaggggaa ggctgtctac ctgaagctgg acttgctggt ggatggtgtg     1020

ctggccctgc gctgcctgga ggaattctca gccactgcgg ccagttccct cgggccccag     1080

ctccgcctct gccaggtgtc tgggctgttg gccctgcggc cagggtcctc cctgcggatc     1140

cgcaccctcc cctgggccca tctcaaggct gcccccttcc tcacctactt cggactcttc     1200

caggttcact ga                                                         1212


<210>  237
<211>  1215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3zICS-41BBCS-TWEAK

<400>  237
cttagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag       60

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt      120

ggccgggacc ctgagatggg gggaaagccg cagagaagga agaaccctca ggaaggcctg      180

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc      240

gagcaaacgg ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt      300

acaaactact caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg      360

atgtgaactg gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc      420

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcgc cgcccgtcgg      480

agccagaggc ggagggggcg ccggggggag ccgggcaccg ccctgctggt cccgctcgcg      540

ctgggcctgg gcctggcgct ggcctgcctc ggcctcctgc tggccgtggt cagtttgggg      600

agccgggcat cgctgtccgc ccaggagcct gcccaggagg agctggtggc agaggaggac      660

caggacccgt cggaactgaa tccccagaca gaagaaagcc aggatcctgc gcctttcctg      720

aaccgactag ttcggcctcg cagaagtgca cctaaaggcc ggaaaacacg ggctcgaaga      780

gcgatcgcag cccattatga agttcatcca cgacctggac aggacggagc gcaggcaggt      840

gtggacggga cagtgagtgg ctgggaggaa gccagaatca acagctccag ccctctgcgc      900

tacaaccgcc agatcgggga gtttatagtc acccgggctg ggctctacta cctgtactgt      960

caggtgcact ttgatgaggg gaaggctgtc tacctgaagc tggacttgct ggtggatggt     1020

gtgctggccc tgcgctgcct ggaggaattc tcagccactg cggccagttc cctcgggccc     1080

cagctccgcc tctgccaggt gtctgggctg ttggccctgc ggccagggtc ctccctgcgg     1140

atccgcaccc tcccctgggc ccatctcaag gctgccccct tcctcaccta cttcggactc     1200

ttccaggttc actga                                                      1215


<210>  238
<211>  1161
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3zICS-DAP10CS-TWEAK

<400>  238
cttagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag       60

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt      120

ggccgggacc ctgagatggg gggaaagccg cagagaagga agaaccctca ggaaggcctg      180

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc      240

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag      300

gacacctacg acgcccttca catgcaggcc ctgccccctc gcctgtgcgc acgcccacgc      360

cgcagccccg cccaagaaga tggcaaagtc tacatcaaca tgccaggcag gggcgccgcc      420

cgtcggagcc agaggcggag ggggcgccgg ggggagccgg gcaccgccct gctggtcccg      480

ctcgcgctgg gcctgggcct ggcgctggcc tgcctcggcc tcctgctggc cgtggtcagt      540

ttggggagcc gggcatcgct gtccgcccag gagcctgccc aggaggagct ggtggcagag      600

gaggaccagg acccgtcgga actgaatccc cagacagaag aaagccagga tcctgcgcct      660

ttcctgaacc gactagttcg gcctcgcaga agtgcaccta aaggccggaa aacacgggct      720

cgaagagcga tcgcagccca ttatgaagtt catccacgac ctggacagga cggagcgcag      780

gcaggtgtgg acgggacagt gagtggctgg gaggaagcca gaatcaacag ctccagccct      840

ctgcgctaca accgccagat cggggagttt atagtcaccc gggctgggct ctactacctg      900

tactgtcagg tgcactttga tgaggggaag gctgtctacc tgaagctgga cttgctggtg      960

gatggtgtgc tggccctgcg ctgcctggag gaattctcag ccactgcggc cagttccctc     1020

gggccccagc tccgcctctg ccaggtgtct gggctgttgg ccctgcggcc agggtcctcc     1080

ctgcggatcc gcaccctccc ctgggcccat ctcaaggctg cccccttcct cacctacttc     1140

ggactcttcc aggttcactg a                                               1161


<210> 239

<400> 239
000


<210>  240
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker (G4S X3)

<400>  240
ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttcc                       45


<210>  241
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 scFvP4A8VHVL

<400>  241
caggtccagc tgcagcagtc tgggcctgag gtggtgaggc ctggggtctc agtgaagatt       60

tcctgcaagg gttccggcta cacattcact gattatggta tgcactgggt gaagcagagt      120

catgcaaaga gtctagagtg gattggagtt attagtactt acaatggtta tacaaactac      180

aaccagaagt ttaagggcaa ggccacaatg actgtagaca aatcctccag cacagcctat      240

atggaacttg ccagattgac atctgaggat tctgccatct attactgtgc aagagcctac      300

tatggtaacc tttactatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttccga cattgtgctg      420

acacagtctc ctgcttcctt agctgtatct ctggggcaga gggccaccat ctcatgcagg      480

gccagcaaaa gtgtcagtac atctagctat agttatatgc actggtacca acagaaacca      540

ggacagccac ccaaactcct catcaagtat gcatccaacc tagaatctgg ggtccctgcc      600

aggttcagtg gcagtgggtc tgggacagac ttcatcctca acatccatcc agtggaggag      660

gaggatgctg caacctatta ctgtcagcac agtagggagc ttccattcac gttcggctcg      720

gggacaaagt tggaaataaa a                                                741


<210>  242
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 scFvP4A8VLVH

<400>  242
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt acatctagct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcatcct caacatccat      240

ccagtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttccattc      300

acgttcggct cggggacaaa gttggaaata aaaggtggtg gtggttctgg cggcggcggc      360

tccggtggtg gtggttccca ggtccagctg cagcagtctg ggcctgaggt ggtgaggcct      420

ggggtctcag tgaagatttc ctgcaagggt tccggctaca cattcactga ttatggtatg      480

cactgggtga agcagagtca tgcaaagagt ctagagtgga ttggagttat tagtacttac      540

aatggttata caaactacaa ccagaagttt aagggcaagg ccacaatgac tgtagacaaa      600

tcctccagca cagcctatat ggaacttgcc agattgacat ctgaggattc tgccatctat      660

tactgtgcaa gagcctacta tggtaacctt tactatgcta tggactactg gggtcaagga      720

acctcagtca ccgtctcctc a                                                741


<210>  243
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 scFvP3G5VHVL

<400>  243
caggtccagc tgcagcagtc tgggcctgag gtggtgaggc ctggggtctc agtgaagatt       60

tcctgcaagg gttccggcta cacattcact gattatggta tacactgggt gaagcagagt      120

catgcaaaga gtctagagtg gattggagtt attagtactt acaatggtta tacaaactac      180

aaccagaagt ttaagggcaa ggccacaatg actgtagaca aatcctccag cacagcctat      240

atggaacttg ccagattgac atctgaggat tctgccatct attactgtgc aagagcctac      300

tatggtaacc tttactatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttccga cattgtgctg      420

acacagtctc ctgcttcctt agctgtatct ctggggcaga gggccaccat ctcatgcagg      480

gccaacaaaa gtgtcagtac atctagctat agttatatgc actggtacca acagaaacca      540

ggacagccac ccaaactcct catcaagtat gcatccaacc tagaatctgg ggtccctgcc      600

aggttcagtg gcagtgggtc tgggacagac ttcatcctca acatccatcc agtggaggag      660

gaggatgctg caacctatta ctgtcagcac agtagggagc ttccattcac gttcggctcg      720

gggacaaagt tggaaataaa a                                                741


<210>  244
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-Fn14 scFvP3G5VLVH

<400>  244
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccaacaa aagtgtcagt acatctagct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcatcct caacatccat      240

ccagtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttccattc      300

acgttcggct cggggacaaa gttggaaata aaaggtggtg gtggttctgg cggcggcggc      360

tccggtggtg gtggttccca ggtccagctg cagcagtctg ggcctgaggt ggtgaggcct      420

ggggtctcag tgaagatttc ctgcaagggt tccggctaca cattcactga ttatggtata      480

cactgggtga agcagagtca tgcaaagagt ctagagtgga ttggagttat tagtacttac      540

aatggttata caaactacaa ccagaagttt aagggcaagg ccacaatgac tgtagacaaa      600

tcctccagca cagcctatat ggaacttgcc agattgacat ctgaggattc tgccatctat      660

tactgtgcaa gagcctacta tggtaacctt tactatgcta tggactactg gggtcaagga      720

acctcagtca ccgtctcctc a                                                741


<210>  245
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CD28 hinge (CD28H)

<400>  245
gtgaaaggga aacacctttg tccaagtccc ctatttcccg gaccttctaa gccc             54


<210>  246
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CD28 transmembrane domain (CD28TM)

<400>  246
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt g                                                 81


<210>  247
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CD3 zeta intracellular signaling domain (CD3zICS)

<400>  247
cttagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag       60

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt      120

ggccgggacc ctgagatggg gggaaagccg cagagaagga agaaccctca ggaaggcctg      180

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc      240

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag      300

gacacctacg acgcccttca catgcaggcc ctgccccctc gc                         342


<210> 248

<400> 248
000

<210> 249

<400> 249
000


<210>  250
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T2A ribosomal skip sequence (T2A)

<400>  250
gccagggcca aaaggtctgg ctccggtgag ggcagaggaa gtcttctaac atgcggtgac       60

gtggaggaga atcccggccc t                                                 81


<210>  251
<211>  984
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human truncated CD19 (trCD19)

<400>  251
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc       60

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag      120

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc      180

ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggccatc      240

tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg      300

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag      360

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc      420

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc      480

aaagaccgcc ctgagatctg ggagggagag cctccgtgtc tcccaccgag ggacagcctg      540

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt      600

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag      660

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg      720

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat      780

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta      840

tggcactggc tgctgaggac tggtggctgg aaggtctcag ctgtgacttt ggcttatctg      900

atcttctgcc tgtgttccct tgtgggcatt cttcatcttc aaagagccct ggtcctgagg      960

aggaaaagaa agcgaatgac ttaa                                             984


<210> 252

<400> 252
000

<210> 253

<400> 253
000

<210> 254

<400> 254
000


<210>  255
<211>  168
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CD27 costimulatory domain (CD27CS)

<400>  255
aggagtaaga ggagcctcga gcaacgaagg aaatatagat caaacaaagg agaaagtcct       60

gtggagcctg cagagccttg tcgttacagc tgccccaggg aggaggaggg cagcaccatc      120

cccatccagg aggattaccg aaaaccggag cctgcctgct cccccaag                   168


<210>  256
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CD28 costimulatory domain (CD28CS)

<400>  256
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc       60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210>  257
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BB costimulatory domain (41BBCS)

<400>  257
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  258
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DAP10 costimulatory domain (DAP10CS)

<400>  258
ctgtgcgcac gcccacgccg cagccccgcc caagaagatg gcaaagtcta catcaacatg       60

ccaggcaggg gc                                                           72


<210> 259

<400> 259
000


<210>  260
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NbMMRm22.84-CD28H-CD28TM-CD28CS-CD3zICS

<400>  260
caggttcagc tgcaagagtc tggcggagga ctggttcaac ctggcggaag cctgagactg       60

tcttgtgccg cttctggcag aaccttcagc aactacgtga actacgccat gggctggttc      120

agacagttcc ccggcaaaga gagagagttc gtcgccagca tcagctggtc tagcgtgacc      180

acctactacg ccgacagcgt gaagggcaga ttcaccatca gcagagacaa cgccaagaac      240

accgtgtacc tgcagatgaa cagcctgaag ccagaggaca ccgccgtgta ctactgtgct      300

gctcacctgg ctcagtacag cgactacgcc tacagagatc cccaccagtt tggcgcttgg      360

ggccagggaa cacaagtgac cgttagctct gtgaaaggga aacacctttg tccaagtccc      420

ctatttcccg gaccttctaa gcccttttgg gtgctggtgg tggttggtgg agtcctggct      480

tgctatagct tgctagtaac agtggccttt attattttct gggtgaggag taagaggagc      540

aggctcctgc acagtgacta catgaacatg actccccgcc gccccgggcc cacccgcaag      600

cattaccagc cctatgcccc accacgcgac ttcgcagcct atcgctccct tagagtgaag      660

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag      720

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct      780

gagatggggg gaaagccgca gagaaggaag aaccctcagg aaggcctgta caatgaactg      840

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg      900

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac      960

gcccttcaca tgcaggccct gccccctcgc                                       990


<210>  261
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NbMMRm5.38-CD28H-CD28TM-CD28CS-CD3zICS

<400>  261
caggttcagc tgcaagagtc tggcggagga ctggttcaag ctggcggaag cctgagactg       60

tcttgtgccg cttctggctt caccgacgac gactacgata tcggctggtt cagacaggcc      120

cctggcaaag agagagaggg cgtcagctgt atcagcagct ctgacggctc tacctactac      180

gccgacagcg tgaagggcag attcaccatc agcagcgaca acgccaagaa caccgtgtac      240

ctgcagatga actctctgaa gcccgaggac accgccgtgt actactgtgc cgccgacttc      300

ttcagatggg acagcggcag ctactacgtg cggggatgta gacacgccac ctacgattac      360

tggggccagg gcacacaagt gaccgtgtca tctgtgaaag ggaaacacct ttgtccaagt      420

cccctatttc ccggaccttc taagcccttt tgggtgctgg tggtggttgg tggagtcctg      480

gcttgctata gcttgctagt aacagtggcc tttattattt tctgggtgag gagtaagagg      540

agcaggctcc tgcacagtga ctacatgaac atgactcccc gccgccccgg gcccacccgc      600

aagcattacc agccctatgc cccaccacgc gacttcgcag cctatcgctc ccttagagtg      660

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac      720

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac      780

cctgagatgg ggggaaagcc gcagagaagg aagaaccctc aggaaggcct gtacaatgaa      840

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg      900

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac      960

gacgcccttc acatgcaggc cctgccccct cgc                                   993


<210>  262
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFvP4A8VHVL-CD28H-CD28TM-CD28CS-CD3zICS

<400>  262
caggtccagc tgcagcagtc tgggcctgag gtggtgaggc ctggggtctc agtgaagatt       60

tcctgcaagg gttccggcta cacattcact gattatggta tgcactgggt gaagcagagt      120

catgcaaaga gtctagagtg gattggagtt attagtactt acaatggtta tacaaactac      180

aaccagaagt ttaagggcaa ggccacaatg actgtagaca aatcctccag cacagcctat      240

atggaacttg ccagattgac atctgaggat tctgccatct attactgtgc aagagcctac      300

tatggtaacc tttactatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttccga cattgtgctg      420

acacagtctc ctgcttcctt agctgtatct ctggggcaga gggccaccat ctcatgcagg      480

gccagcaaaa gtgtcagtac atctagctat agttatatgc actggtacca acagaaacca      540

ggacagccac ccaaactcct catcaagtat gcatccaacc tagaatctgg ggtccctgcc      600

aggttcagtg gcagtgggtc tgggacagac ttcatcctca acatccatcc agtggaggag      660

gaggatgctg caacctatta ctgtcagcac agtagggagc ttccattcac gttcggctcg      720

gggacaaagt tggaaataaa agtgaaaggg aaacaccttt gtccaagtcc cctatttccc      780

ggaccttcta agcccttttg ggtgctggtg gtggttggtg gagtcctggc ttgctatagc      840

ttgctagtaa cagtggcctt tattattttc tgggtgagga gtaagaggag caggctcctg      900

cacagtgact acatgaacat gactccccgc cgccccgggc ccacccgcaa gcattaccag      960

ccctatgccc caccacgcga cttcgcagcc tatcgctccc ttagagtgaa gttcagcagg     1020

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1080

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1140

ggaaagccgc agagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1200

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1260

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1320

atgcaggccc tgccccctcg c                                               1341


<210>  263
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFvP4A8VLVH-CD28H-CD28TM-CD28CS-CD3zICS

<400>  263
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt acatctagct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcatcct caacatccat      240

ccagtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttccattc      300

acgttcggct cggggacaaa gttggaaata aaaggtggtg gtggttctgg cggcggcggc      360

tccggtggtg gtggttccca ggtccagctg cagcagtctg ggcctgaggt ggtgaggcct      420

ggggtctcag tgaagatttc ctgcaagggt tccggctaca cattcactga ttatggtatg      480

cactgggtga agcagagtca tgcaaagagt ctagagtgga ttggagttat tagtacttac      540

aatggttata caaactacaa ccagaagttt aagggcaagg ccacaatgac tgtagacaaa      600

tcctccagca cagcctatat ggaacttgcc agattgacat ctgaggattc tgccatctat      660

tactgtgcaa gagcctacta tggtaacctt tactatgcta tggactactg gggtcaagga      720

acctcagtca ccgtctcctc agtgaaaggg aaacaccttt gtccaagtcc cctatttccc      780

ggaccttcta agcccttttg ggtgctggtg gtggttggtg gagtcctggc ttgctatagc      840

ttgctagtaa cagtggcctt tattattttc tgggtgagga gtaagaggag caggctcctg      900

cacagtgact acatgaacat gactccccgc cgccccgggc ccacccgcaa gcattaccag      960

ccctatgccc caccacgcga cttcgcagcc tatcgctccc ttagagtgaa gttcagcagg     1020

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1080

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1140

ggaaagccgc agagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1200

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1260

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1320

atgcaggccc tgccccctcg c                                               1341


<210>  264
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFvP3G5VHVL-CD28H-CD28TM-CD28CS-CD3zICS

<400>  264
caggtccagc tgcagcagtc tgggcctgag gtggtgaggc ctggggtctc agtgaagatt       60

tcctgcaagg gttccggcta cacattcact gattatggta tacactgggt gaagcagagt      120

catgcaaaga gtctagagtg gattggagtt attagtactt acaatggtta tacaaactac      180

aaccagaagt ttaagggcaa ggccacaatg actgtagaca aatcctccag cacagcctat      240

atggaacttg ccagattgac atctgaggat tctgccatct attactgtgc aagagcctac      300

tatggtaacc tttactatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttccga cattgtgctg      420

acacagtctc ctgcttcctt agctgtatct ctggggcaga gggccaccat ctcatgcagg      480

gccaacaaaa gtgtcagtac atctagctat agttatatgc actggtacca acagaaacca      540

ggacagccac ccaaactcct catcaagtat gcatccaacc tagaatctgg ggtccctgcc      600

aggttcagtg gcagtgggtc tgggacagac ttcatcctca acatccatcc agtggaggag      660

gaggatgctg caacctatta ctgtcagcac agtagggagc ttccattcac gttcggctcg      720

gggacaaagt tggaaataaa agtgaaaggg aaacaccttt gtccaagtcc cctatttccc      780

ggaccttcta agcccttttg ggtgctggtg gtggttggtg gagtcctggc ttgctatagc      840

ttgctagtaa cagtggcctt tattattttc tgggtgagga gtaagaggag caggctcctg      900

cacagtgact acatgaacat gactccccgc cgccccgggc ccacccgcaa gcattaccag      960

ccctatgccc caccacgcga cttcgcagcc tatcgctccc ttagagtgaa gttcagcagg     1020

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1080

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1140

ggaaagccgc agagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1200

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1260

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1320

atgcaggccc tgccccctcg c                                               1341


<210>  265
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFvP3G5VLVH-CD28H-CD28TM-CD28CS-CD3zICS

<400>  265
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccaacaa aagtgtcagt acatctagct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcatcct caacatccat      240

ccagtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttccattc      300

acgttcggct cggggacaaa gttggaaata aaaggtggtg gtggttctgg cggcggcggc      360

tccggtggtg gtggttccca ggtccagctg cagcagtctg ggcctgaggt ggtgaggcct      420

ggggtctcag tgaagatttc ctgcaagggt tccggctaca cattcactga ttatggtata      480

cactgggtga agcagagtca tgcaaagagt ctagagtgga ttggagttat tagtacttac      540

aatggttata caaactacaa ccagaagttt aagggcaagg ccacaatgac tgtagacaaa      600

tcctccagca cagcctatat ggaacttgcc agattgacat ctgaggattc tgccatctat      660

tactgtgcaa gagcctacta tggtaacctt tactatgcta tggactactg gggtcaagga      720

acctcagtca ccgtctcctc agtgaaaggg aaacaccttt gtccaagtcc cctatttccc      780

ggaccttcta agcccttttg ggtgctggtg gtggttggtg gagtcctggc ttgctatagc      840

ttgctagtaa cagtggcctt tattattttc tgggtgagga gtaagaggag caggctcctg      900

cacagtgact acatgaacat gactccccgc cgccccgggc ccacccgcaa gcattaccag      960

ccctatgccc caccacgcga cttcgcagcc tatcgctccc ttagagtgaa gttcagcagg     1020

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1080

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1140

ggaaagccgc agagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1200

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1260

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1320

atgcaggccc tgccccctcg c                                               1341


<210>  266
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NbMMRm22.84-CD28H-CD28TM-41BBCS-CD3zICS

<400>  266
caggttcagc tgcaagagtc tggcggagga ctggttcaac ctggcggaag cctgagactg       60

tcttgtgccg cttctggcag aaccttcagc aactacgtga actacgccat gggctggttc      120

agacagttcc ccggcaaaga gagagagttc gtcgccagca tcagctggtc tagcgtgacc      180

acctactacg ccgacagcgt gaagggcaga ttcaccatca gcagagacaa cgccaagaac      240

accgtgtacc tgcagatgaa cagcctgaag ccagaggaca ccgccgtgta ctactgtgct      300

gctcacctgg ctcagtacag cgactacgcc tacagagatc cccaccagtt tggcgcttgg      360

ggccagggaa cacaagtgac cgttagctct gtgaaaggga aacacctttg tccaagtccc      420

ctatttcccg gaccttctaa gcccttttgg gtgctggtgg tggttggtgg agtcctggct      480

tgctatagct tgctagtaac agtggccttt attattttct gggtgaaacg gggcagaaag      540

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa      600

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gcttagagtg      660

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac      720

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac      780

cctgagatgg ggggaaagcc gcagagaagg aagaaccctc aggaaggcct gtacaatgaa      840

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg      900

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac      960

gacgcccttc acatgcaggc cctgccccct cgc                                   993


<210>  267
<211>  996
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NbMMRm5.38-CD28H-CD28TM-41BBCS-CD3zICS

<400>  267
caggttcagc tgcaagagtc tggcggagga ctggttcaag ctggcggaag cctgagactg       60

tcttgtgccg cttctggctt caccgacgac gactacgata tcggctggtt cagacaggcc      120

cctggcaaag agagagaggg cgtcagctgt atcagcagct ctgacggctc tacctactac      180

gccgacagcg tgaagggcag attcaccatc agcagcgaca acgccaagaa caccgtgtac      240

ctgcagatga actctctgaa gcccgaggac accgccgtgt actactgtgc cgccgacttc      300

ttcagatggg acagcggcag ctactacgtg cggggatgta gacacgccac ctacgattac      360

tggggccagg gcacacaagt gaccgtgtca tctgtgaaag ggaaacacct ttgtccaagt      420

cccctatttc ccggaccttc taagcccttt tgggtgctgg tggtggttgg tggagtcctg      480

gcttgctata gcttgctagt aacagtggcc tttattattt tctgggtgaa acggggcaga      540

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag      600

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgcttaga      660

gtgaagttca gcaggagcgc agacgccccc gcgtaccagc agggccagaa ccagctctat      720

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg      780

gaccctgaga tggggggaaa gccgcagaga aggaagaacc ctcaggaagg cctgtacaat      840

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      900

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      960

tacgacgccc ttcacatgca ggccctgccc cctcgc                                996


<210>  268
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFvP4A8VHVL-CD28H-CD28TM-41BBCS-CD3zICS

<400>  268
caggtccagc tgcagcagtc tgggcctgag gtggtgaggc ctggggtctc agtgaagatt       60

tcctgcaagg gttccggcta cacattcact gattatggta tgcactgggt gaagcagagt      120

catgcaaaga gtctagagtg gattggagtt attagtactt acaatggtta tacaaactac      180

aaccagaagt ttaagggcaa ggccacaatg actgtagaca aatcctccag cacagcctat      240

atggaacttg ccagattgac atctgaggat tctgccatct attactgtgc aagagcctac      300

tatggtaacc tttactatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttccga cattgtgctg      420

acacagtctc ctgcttcctt agctgtatct ctggggcaga gggccaccat ctcatgcagg      480

gccagcaaaa gtgtcagtac atctagctat agttatatgc actggtacca acagaaacca      540

ggacagccac ccaaactcct catcaagtat gcatccaacc tagaatctgg ggtccctgcc      600

aggttcagtg gcagtgggtc tgggacagac ttcatcctca acatccatcc agtggaggag      660

gaggatgctg caacctatta ctgtcagcac agtagggagc ttccattcac gttcggctcg      720

gggacaaagt tggaaataaa agtgaaaggg aaacaccttt gtccaagtcc cctatttccc      780

ggaccttcta agcccttttg ggtgctggtg gtggttggtg gagtcctggc ttgctatagc      840

ttgctagtaa cagtggcctt tattattttc tgggtgaaac ggggcagaaa gaaactcctg      900

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt      960

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgcttagagt gaagttcagc     1020

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1080

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1140

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1200

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1260

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1320

cacatgcagg ccctgccccc tcgc                                            1344


<210>  269
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFvP4A8VLVH-CD28H-CD28TM-41BBCS-CD3zICS

<400>  269
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt acatctagct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcatcct caacatccat      240

ccagtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttccattc      300

acgttcggct cggggacaaa gttggaaata aaaggtggtg gtggttctgg cggcggcggc      360

tccggtggtg gtggttccca ggtccagctg cagcagtctg ggcctgaggt ggtgaggcct      420

ggggtctcag tgaagatttc ctgcaagggt tccggctaca cattcactga ttatggtatg      480

cactgggtga agcagagtca tgcaaagagt ctagagtgga ttggagttat tagtacttac      540

aatggttata caaactacaa ccagaagttt aagggcaagg ccacaatgac tgtagacaaa      600

tcctccagca cagcctatat ggaacttgcc agattgacat ctgaggattc tgccatctat      660

tactgtgcaa gagcctacta tggtaacctt tactatgcta tggactactg gggtcaagga      720

acctcagtca ccgtctcctc agtgaaaggg aaacaccttt gtccaagtcc cctatttccc      780

ggaccttcta agcccttttg ggtgctggtg gtggttggtg gagtcctggc ttgctatagc      840

ttgctagtaa cagtggcctt tattattttc tgggtgaaac ggggcagaaa gaaactcctg      900

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt      960

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgcttagagt gaagttcagc     1020

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1080

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1140

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1200

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1260

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1320

cacatgcagg ccctgccccc tcgc                                            1344


<210>  270
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFvP3G5VHVL-CD28H-CD28TM-41BBCS-CD3zICS

<400>  270
caggtccagc tgcagcagtc tgggcctgag gtggtgaggc ctggggtctc agtgaagatt       60

tcctgcaagg gttccggcta cacattcact gattatggta tacactgggt gaagcagagt      120

catgcaaaga gtctagagtg gattggagtt attagtactt acaatggtta tacaaactac      180

aaccagaagt ttaagggcaa ggccacaatg actgtagaca aatcctccag cacagcctat      240

atggaacttg ccagattgac atctgaggat tctgccatct attactgtgc aagagcctac      300

tatggtaacc tttactatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttccga cattgtgctg      420

acacagtctc ctgcttcctt agctgtatct ctggggcaga gggccaccat ctcatgcagg      480

gccaacaaaa gtgtcagtac atctagctat agttatatgc actggtacca acagaaacca      540

ggacagccac ccaaactcct catcaagtat gcatccaacc tagaatctgg ggtccctgcc      600

aggttcagtg gcagtgggtc tgggacagac ttcatcctca acatccatcc agtggaggag      660

gaggatgctg caacctatta ctgtcagcac agtagggagc ttccattcac gttcggctcg      720

gggacaaagt tggaaataaa agtgaaaggg aaacaccttt gtccaagtcc cctatttccc      780

ggaccttcta agcccttttg ggtgctggtg gtggttggtg gagtcctggc ttgctatagc      840

ttgctagtaa cagtggcctt tattattttc tgggtgaaac ggggcagaaa gaaactcctg      900

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt      960

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgcttagagt gaagttcagc     1020

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1080

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1140

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1200

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1260

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1320

cacatgcagg ccctgccccc tcgc                                            1344


<210>  271
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFvP3G5VLVH-CD28H-CD28TM-41BBCS-CD3zICS

<400>  271
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccaacaa aagtgtcagt acatctagct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcatcct caacatccat      240

ccagtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttccattc      300

acgttcggct cggggacaaa gttggaaata aaaggtggtg gtggttctgg cggcggcggc      360

tccggtggtg gtggttccca ggtccagctg cagcagtctg ggcctgaggt ggtgaggcct      420

ggggtctcag tgaagatttc ctgcaagggt tccggctaca cattcactga ttatggtata      480

cactgggtga agcagagtca tgcaaagagt ctagagtgga ttggagttat tagtacttac      540

aatggttata caaactacaa ccagaagttt aagggcaagg ccacaatgac tgtagacaaa      600

tcctccagca cagcctatat ggaacttgcc agattgacat ctgaggattc tgccatctat      660

tactgtgcaa gagcctacta tggtaacctt tactatgcta tggactactg gggtcaagga      720

acctcagtca ccgtctcctc agtgaaaggg aaacaccttt gtccaagtcc cctatttccc      780

ggaccttcta agcccttttg ggtgctggtg gtggttggtg gagtcctggc ttgctatagc      840

ttgctagtaa cagtggcctt tattattttc tgggtgaaac ggggcagaaa gaaactcctg      900

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt      960

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgcttagagt gaagttcagc     1020

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1080

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1140

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1200

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1260

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1320

cacatgcagg ccctgccccc tcgc                                            1344


<210>  272
<211>  939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NbMMRm22.84-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  272
caggttcagc tgcaagagtc tggcggagga ctggttcaac ctggcggaag cctgagactg       60

tcttgtgccg cttctggcag aaccttcagc aactacgtga actacgccat gggctggttc      120

agacagttcc ccggcaaaga gagagagttc gtcgccagca tcagctggtc tagcgtgacc      180

acctactacg ccgacagcgt gaagggcaga ttcaccatca gcagagacaa cgccaagaac      240

accgtgtacc tgcagatgaa cagcctgaag ccagaggaca ccgccgtgta ctactgtgct      300

gctcacctgg ctcagtacag cgactacgcc tacagagatc cccaccagtt tggcgcttgg      360

ggccagggaa cacaagtgac cgttagctct gtgaaaggga aacacctttg tccaagtccc      420

ctatttcccg gaccttctaa gcccttttgg gtgctggtgg tggttggtgg agtcctggct      480

tgctatagct tgctagtaac agtggccttt attattttct gggtgctgtg cgcacgccca      540

cgccgcagcc ccgcccaaga agatggcaaa gtctacatca acatgccagg caggggcctt      600

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc      660

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      720

cgggaccctg agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac      780

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag      840

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac      900

acctacgacg cccttcacat gcaggccctg ccccctcgc                             939


<210>  273
<211>  942
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NbMMRm5.38-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  273
caggttcagc tgcaagagtc tggcggagga ctggttcaag ctggcggaag cctgagactg       60

tcttgtgccg cttctggctt caccgacgac gactacgata tcggctggtt cagacaggcc      120

cctggcaaag agagagaggg cgtcagctgt atcagcagct ctgacggctc tacctactac      180

gccgacagcg tgaagggcag attcaccatc agcagcgaca acgccaagaa caccgtgtac      240

ctgcagatga actctctgaa gcccgaggac accgccgtgt actactgtgc cgccgacttc      300

ttcagatggg acagcggcag ctactacgtg cggggatgta gacacgccac ctacgattac      360

tggggccagg gcacacaagt gaccgtgtca tctgtgaaag ggaaacacct ttgtccaagt      420

cccctatttc ccggaccttc taagcccttt tgggtgctgg tggtggttgg tggagtcctg      480

gcttgctata gcttgctagt aacagtggcc tttattattt tctgggtgct gtgcgcacgc      540

ccacgccgca gccccgccca agaagatggc aaagtctaca tcaacatgcc aggcaggggc      600

cttagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag      660

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt      720

ggccgggacc ctgagatggg gggaaagccg cagagaagga agaaccctca ggaaggcctg      780

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc      840

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag      900

gacacctacg acgcccttca catgcaggcc ctgccccctc gc                         942


<210>  274
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFvP4A8VHVL-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  274
caggtccagc tgcagcagtc tgggcctgag gtggtgaggc ctggggtctc agtgaagatt       60

tcctgcaagg gttccggcta cacattcact gattatggta tgcactgggt gaagcagagt      120

catgcaaaga gtctagagtg gattggagtt attagtactt acaatggtta tacaaactac      180

aaccagaagt ttaagggcaa ggccacaatg actgtagaca aatcctccag cacagcctat      240

atggaacttg ccagattgac atctgaggat tctgccatct attactgtgc aagagcctac      300

tatggtaacc tttactatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttccga cattgtgctg      420

acacagtctc ctgcttcctt agctgtatct ctggggcaga gggccaccat ctcatgcagg      480

gccagcaaaa gtgtcagtac atctagctat agttatatgc actggtacca acagaaacca      540

ggacagccac ccaaactcct catcaagtat gcatccaacc tagaatctgg ggtccctgcc      600

aggttcagtg gcagtgggtc tgggacagac ttcatcctca acatccatcc agtggaggag      660

gaggatgctg caacctatta ctgtcagcac agtagggagc ttccattcac gttcggctcg      720

gggacaaagt tggaaataaa agtgaaaggg aaacaccttt gtccaagtcc cctatttccc      780

ggaccttcta agcccttttg ggtgctggtg gtggttggtg gagtcctggc ttgctatagc      840

ttgctagtaa cagtggcctt tattattttc tgggtgctgt gcgcacgccc acgccgcagc      900

cccgcccaag aagatggcaa agtctacatc aacatgccag gcaggggcct tagagtgaag      960

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag     1020

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1080

gagatggggg gaaagccgca gagaaggaag aaccctcagg aaggcctgta caatgaactg     1140

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1200

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1260

gcccttcaca tgcaggccct gccccctcgc                                      1290


<210>  275
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFvP4A8VLVH-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  275
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt acatctagct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcatcct caacatccat      240

ccagtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttccattc      300

acgttcggct cggggacaaa gttggaaata aaaggtggtg gtggttctgg cggcggcggc      360

tccggtggtg gtggttccca ggtccagctg cagcagtctg ggcctgaggt ggtgaggcct      420

ggggtctcag tgaagatttc ctgcaagggt tccggctaca cattcactga ttatggtatg      480

cactgggtga agcagagtca tgcaaagagt ctagagtgga ttggagttat tagtacttac      540

aatggttata caaactacaa ccagaagttt aagggcaagg ccacaatgac tgtagacaaa      600

tcctccagca cagcctatat ggaacttgcc agattgacat ctgaggattc tgccatctat      660

tactgtgcaa gagcctacta tggtaacctt tactatgcta tggactactg gggtcaagga      720

acctcagtca ccgtctcctc agtgaaaggg aaacaccttt gtccaagtcc cctatttccc      780

ggaccttcta agcccttttg ggtgctggtg gtggttggtg gagtcctggc ttgctatagc      840

ttgctagtaa cagtggcctt tattattttc tgggtgctgt gcgcacgccc acgccgcagc      900

cccgcccaag aagatggcaa agtctacatc aacatgccag gcaggggcct tagagtgaag      960

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag     1020

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1080

gagatggggg gaaagccgca gagaaggaag aaccctcagg aaggcctgta caatgaactg     1140

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1200

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1260

gcccttcaca tgcaggccct gccccctcgc                                      1290


<210>  276
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFvP3G5VHVL-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  276
caggtccagc tgcagcagtc tgggcctgag gtggtgaggc ctggggtctc agtgaagatt       60

tcctgcaagg gttccggcta cacattcact gattatggta tacactgggt gaagcagagt      120

catgcaaaga gtctagagtg gattggagtt attagtactt acaatggtta tacaaactac      180

aaccagaagt ttaagggcaa ggccacaatg actgtagaca aatcctccag cacagcctat      240

atggaacttg ccagattgac atctgaggat tctgccatct attactgtgc aagagcctac      300

tatggtaacc tttactatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttccga cattgtgctg      420

acacagtctc ctgcttcctt agctgtatct ctggggcaga gggccaccat ctcatgcagg      480

gccaacaaaa gtgtcagtac atctagctat agttatatgc actggtacca acagaaacca      540

ggacagccac ccaaactcct catcaagtat gcatccaacc tagaatctgg ggtccctgcc      600

aggttcagtg gcagtgggtc tgggacagac ttcatcctca acatccatcc agtggaggag      660

gaggatgctg caacctatta ctgtcagcac agtagggagc ttccattcac gttcggctcg      720

gggacaaagt tggaaataaa agtgaaaggg aaacaccttt gtccaagtcc cctatttccc      780

ggaccttcta agcccttttg ggtgctggtg gtggttggtg gagtcctggc ttgctatagc      840

ttgctagtaa cagtggcctt tattattttc tgggtgctgt gcgcacgccc acgccgcagc      900

cccgcccaag aagatggcaa agtctacatc aacatgccag gcaggggcct tagagtgaag      960

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag     1020

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1080

gagatggggg gaaagccgca gagaaggaag aaccctcagg aaggcctgta caatgaactg     1140

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1200

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1260

gcccttcaca tgcaggccct gccccctcgc                                      1290


<210>  277
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFvP3G5VLVH-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  277
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccaacaa aagtgtcagt acatctagct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcatcct caacatccat      240

ccagtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttccattc      300

acgttcggct cggggacaaa gttggaaata aaaggtggtg gtggttctgg cggcggcggc      360

tccggtggtg gtggttccca ggtccagctg cagcagtctg ggcctgaggt ggtgaggcct      420

ggggtctcag tgaagatttc ctgcaagggt tccggctaca cattcactga ttatggtata      480

cactgggtga agcagagtca tgcaaagagt ctagagtgga ttggagttat tagtacttac      540

aatggttata caaactacaa ccagaagttt aagggcaagg ccacaatgac tgtagacaaa      600

tcctccagca cagcctatat ggaacttgcc agattgacat ctgaggattc tgccatctat      660

tactgtgcaa gagcctacta tggtaacctt tactatgcta tggactactg gggtcaagga      720

acctcagtca ccgtctcctc agtgaaaggg aaacaccttt gtccaagtcc cctatttccc      780

ggaccttcta agcccttttg ggtgctggtg gtggttggtg gagtcctggc ttgctatagc      840

ttgctagtaa cagtggcctt tattattttc tgggtgctgt gcgcacgccc acgccgcagc      900

cccgcccaag aagatggcaa agtctacatc aacatgccag gcaggggcct tagagtgaag      960

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag     1020

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1080

gagatggggg gaaagccgca gagaaggaag aaccctcagg aaggcctgta caatgaactg     1140

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1200

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1260

gcccttcaca tgcaggccct gccccctcgc                                      1290


<210>  278
<211>  2112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm22.84-CD28H-CD28TM-CD28CS-CD3zICS-T2A-trCD19

<400>  278
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gttcagctgc aagagtctgg cggaggactg gttcaacctg gcggaagcct gagactgtct      120

tgtgccgctt ctggcagaac cttcagcaac tacgtgaact acgccatggg ctggttcaga      180

cagttccccg gcaaagagag agagttcgtc gccagcatca gctggtctag cgtgaccacc      240

tactacgccg acagcgtgaa gggcagattc accatcagca gagacaacgc caagaacacc      300

gtgtacctgc agatgaacag cctgaagcca gaggacaccg ccgtgtacta ctgtgctgct      360

cacctggctc agtacagcga ctacgcctac agagatcccc accagtttgg cgcttggggc      420

cagggaacac aagtgaccgt tagctctgtg aaagggaaac acctttgtcc aagtccccta      480

tttcccggac cttctaagcc cttttgggtg ctggtggtgg ttggtggagt cctggcttgc      540

tatagcttgc tagtaacagt ggcctttatt attttctggg tgaggagtaa gaggagcagg      600

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat      660

taccagccct atgccccacc acgcgacttc gcagcctatc gctcccttag agtgaagttc      720

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc      780

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag      840

atggggggaa agccgcagag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag      900

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc      960

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1020

cttcacatgc aggccctgcc ccctcgcgcc agggccaaaa ggtctggctc cggtgagggc     1080

agaggaagtc ttctaacatg cggtgacgtg gaggagaatc ccggccctat gccacctcct     1140

cgcctcctct tcttcctcct cttcctcacc cccatggaag tcaggcccga ggaacctcta     1200

gtggtgaagg tggaagaggg agataacgct gtgctgcagt gcctcaaggg gacctcagat     1260

ggccccactc agcagctgac ctggtctcgg gagtccccgc ttaaaccctt cttaaaactc     1320

agcctggggc tgccaggcct gggaatccac atgaggcccc tggccatctg gcttttcatc     1380

ttcaacgtct ctcaacagat ggggggcttc tacctgtgcc agccggggcc cccctctgag     1440

aaggcctggc agcctggctg gacagtcaat gtggagggca gcggggagct gttccggtgg     1500

aatgtttcgg acctaggtgg cctgggctgt ggcctgaaga acaggtcctc agagggcccc     1560

agctcccctt ccgggaagct catgagcccc aagctgtatg tgtgggccaa agaccgccct     1620

gagatctggg agggagagcc tccgtgtctc ccaccgaggg acagcctgaa ccagagcctc     1680

agccaggacc tcaccatggc ccctggctcc acactctggc tgtcctgtgg ggtaccccct     1740

gactctgtgt ccaggggccc cctctcctgg acccatgtgc accccaaggg gcctaagtca     1800

ttgctgagcc tagagctgaa ggacgatcgc ccggccagag atatgtgggt aatggagacg     1860

ggtctgttgt tgccccgggc cacagctcaa gacgctggaa agtattattg tcaccgtggc     1920

aacctgacca tgtcattcca cctggagatc actgctcggc cagtactatg gcactggctg     1980

ctgaggactg gtggctggaa ggtctcagct gtgactttgg cttatctgat cttctgcctg     2040

tgttcccttg tgggcattct tcatcttcaa agagccctgg tcctgaggag gaaaagaaag     2100

cgaatgactt aa                                                         2112


<210>  279
<211>  2115
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm5.38-CD28H-CD28TM-CD28CS-CD3zICS-T2A-trCD19

<400>  279
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gttcagctgc aagagtctgg cggaggactg gttcaagctg gcggaagcct gagactgtct      120

tgtgccgctt ctggcttcac cgacgacgac tacgatatcg gctggttcag acaggcccct      180

ggcaaagaga gagagggcgt cagctgtatc agcagctctg acggctctac ctactacgcc      240

gacagcgtga agggcagatt caccatcagc agcgacaacg ccaagaacac cgtgtacctg      300

cagatgaact ctctgaagcc cgaggacacc gccgtgtact actgtgccgc cgacttcttc      360

agatgggaca gcggcagcta ctacgtgcgg ggatgtagac acgccaccta cgattactgg      420

ggccagggca cacaagtgac cgtgtcatct gtgaaaggga aacacctttg tccaagtccc      480

ctatttcccg gaccttctaa gcccttttgg gtgctggtgg tggttggtgg agtcctggct      540

tgctatagct tgctagtaac agtggccttt attattttct gggtgaggag taagaggagc      600

aggctcctgc acagtgacta catgaacatg actccccgcc gccccgggcc cacccgcaag      660

cattaccagc cctatgcccc accacgcgac ttcgcagcct atcgctccct tagagtgaag      720

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag      780

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct      840

gagatggggg gaaagccgca gagaaggaag aaccctcagg aaggcctgta caatgaactg      900

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg      960

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1020

gcccttcaca tgcaggccct gccccctcgc gccagggcca aaaggtctgg ctccggtgag     1080

ggcagaggaa gtcttctaac atgcggtgac gtggaggaga atcccggccc tatgccacct     1140

cctcgcctcc tcttcttcct cctcttcctc acccccatgg aagtcaggcc cgaggaacct     1200

ctagtggtga aggtggaaga gggagataac gctgtgctgc agtgcctcaa ggggacctca     1260

gatggcccca ctcagcagct gacctggtct cgggagtccc cgcttaaacc cttcttaaaa     1320

ctcagcctgg ggctgccagg cctgggaatc cacatgaggc ccctggccat ctggcttttc     1380

atcttcaacg tctctcaaca gatggggggc ttctacctgt gccagccggg gcccccctct     1440

gagaaggcct ggcagcctgg ctggacagtc aatgtggagg gcagcgggga gctgttccgg     1500

tggaatgttt cggacctagg tggcctgggc tgtggcctga agaacaggtc ctcagagggc     1560

cccagctccc cttccgggaa gctcatgagc cccaagctgt atgtgtgggc caaagaccgc     1620

cctgagatct gggagggaga gcctccgtgt ctcccaccga gggacagcct gaaccagagc     1680

ctcagccagg acctcaccat ggcccctggc tccacactct ggctgtcctg tggggtaccc     1740

cctgactctg tgtccagggg ccccctctcc tggacccatg tgcaccccaa ggggcctaag     1800

tcattgctga gcctagagct gaaggacgat cgcccggcca gagatatgtg ggtaatggag     1860

acgggtctgt tgttgccccg ggccacagct caagacgctg gaaagtatta ttgtcaccgt     1920

ggcaacctga ccatgtcatt ccacctggag atcactgctc ggccagtact atggcactgg     1980

ctgctgagga ctggtggctg gaaggtctca gctgtgactt tggcttatct gatcttctgc     2040

ctgtgttccc ttgtgggcat tcttcatctt caaagagccc tggtcctgag gaggaaaaga     2100

aagcgaatga cttaa                                                      2115


<210>  280
<211>  2463
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VHVL-CD28H-CD28TM-CD28CS-CD3zICS-T2A-trCD19

<400>  280
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gtccagctgc agcagtctgg gcctgaggtg gtgaggcctg gggtctcagt gaagatttcc      120

tgcaagggtt ccggctacac attcactgat tatggtatgc actgggtgaa gcagagtcat      180

gcaaagagtc tagagtggat tggagttatt agtacttaca atggttatac aaactacaac      240

cagaagttta agggcaaggc cacaatgact gtagacaaat cctccagcac agcctatatg      300

gaacttgcca gattgacatc tgaggattct gccatctatt actgtgcaag agcctactat      360

ggtaaccttt actatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      420

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgacat tgtgctgaca      480

cagtctcctg cttccttagc tgtatctctg gggcagaggg ccaccatctc atgcagggcc      540

agcaaaagtg tcagtacatc tagctatagt tatatgcact ggtaccaaca gaaaccagga      600

cagccaccca aactcctcat caagtatgca tccaacctag aatctggggt ccctgccagg      660

ttcagtggca gtgggtctgg gacagacttc atcctcaaca tccatccagt ggaggaggag      720

gatgctgcaa cctattactg tcagcacagt agggagcttc cattcacgtt cggctcgggg      780

acaaagttgg aaataaaagt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgaggagta agaggagcag gctcctgcac      960

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc     1020

tatgccccac cacgcgactt cgcagcctat cgctccctta gagtgaagtt cagcaggagc     1080

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1140

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     1200

aagccgcaga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1260

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1320

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1380

caggccctgc cccctcgcgc cagggccaaa aggtctggct ccggtgaggg cagaggaagt     1440

cttctaacat gcggtgacgt ggaggagaat cccggcccta tgccacctcc tcgcctcctc     1500

ttcttcctcc tcttcctcac ccccatggaa gtcaggcccg aggaacctct agtggtgaag     1560

gtggaagagg gagataacgc tgtgctgcag tgcctcaagg ggacctcaga tggccccact     1620

cagcagctga cctggtctcg ggagtccccg cttaaaccct tcttaaaact cagcctgggg     1680

ctgccaggcc tgggaatcca catgaggccc ctggccatct ggcttttcat cttcaacgtc     1740

tctcaacaga tggggggctt ctacctgtgc cagccggggc ccccctctga gaaggcctgg     1800

cagcctggct ggacagtcaa tgtggagggc agcggggagc tgttccggtg gaatgtttcg     1860

gacctaggtg gcctgggctg tggcctgaag aacaggtcct cagagggccc cagctcccct     1920

tccgggaagc tcatgagccc caagctgtat gtgtgggcca aagaccgccc tgagatctgg     1980

gagggagagc ctccgtgtct cccaccgagg gacagcctga accagagcct cagccaggac     2040

ctcaccatgg cccctggctc cacactctgg ctgtcctgtg gggtaccccc tgactctgtg     2100

tccaggggcc ccctctcctg gacccatgtg caccccaagg ggcctaagtc attgctgagc     2160

ctagagctga aggacgatcg cccggccaga gatatgtggg taatggagac gggtctgttg     2220

ttgccccggg ccacagctca agacgctgga aagtattatt gtcaccgtgg caacctgacc     2280

atgtcattcc acctggagat cactgctcgg ccagtactat ggcactggct gctgaggact     2340

ggtggctgga aggtctcagc tgtgactttg gcttatctga tcttctgcct gtgttccctt     2400

gtgggcattc ttcatcttca aagagccctg gtcctgagga ggaaaagaaa gcgaatgact     2460

taa                                                                   2463


<210>  281
<211>  2463
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VLVH-CD28H-CD28TM-CD28CS-CD3zICS-T2A-trCD19

<400>  281
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagcgac       60

attgtgctga cacagtctcc tgcttcctta gctgtatctc tggggcagag ggccaccatc      120

tcatgcaggg ccagcaaaag tgtcagtaca tctagctata gttatatgca ctggtaccaa      180

cagaaaccag gacagccacc caaactcctc atcaagtatg catccaacct agaatctggg      240

gtccctgcca ggttcagtgg cagtgggtct gggacagact tcatcctcaa catccatcca      300

gtggaggagg aggatgctgc aacctattac tgtcagcaca gtagggagct tccattcacg      360

ttcggctcgg ggacaaagtt ggaaataaaa ggtggtggtg gttctggcgg cggcggctcc      420

ggtggtggtg gttcccaggt ccagctgcag cagtctgggc ctgaggtggt gaggcctggg      480

gtctcagtga agatttcctg caagggttcc ggctacacat tcactgatta tggtatgcac      540

tgggtgaagc agagtcatgc aaagagtcta gagtggattg gagttattag tacttacaat      600

ggttatacaa actacaacca gaagtttaag ggcaaggcca caatgactgt agacaaatcc      660

tccagcacag cctatatgga acttgccaga ttgacatctg aggattctgc catctattac      720

tgtgcaagag cctactatgg taacctttac tatgctatgg actactgggg tcaaggaacc      780

tcagtcaccg tctcctcagt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgaggagta agaggagcag gctcctgcac      960

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc     1020

tatgccccac cacgcgactt cgcagcctat cgctccctta gagtgaagtt cagcaggagc     1080

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1140

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     1200

aagccgcaga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1260

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1320

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1380

caggccctgc cccctcgcgc cagggccaaa aggtctggct ccggtgaggg cagaggaagt     1440

cttctaacat gcggtgacgt ggaggagaat cccggcccta tgccacctcc tcgcctcctc     1500

ttcttcctcc tcttcctcac ccccatggaa gtcaggcccg aggaacctct agtggtgaag     1560

gtggaagagg gagataacgc tgtgctgcag tgcctcaagg ggacctcaga tggccccact     1620

cagcagctga cctggtctcg ggagtccccg cttaaaccct tcttaaaact cagcctgggg     1680

ctgccaggcc tgggaatcca catgaggccc ctggccatct ggcttttcat cttcaacgtc     1740

tctcaacaga tggggggctt ctacctgtgc cagccggggc ccccctctga gaaggcctgg     1800

cagcctggct ggacagtcaa tgtggagggc agcggggagc tgttccggtg gaatgtttcg     1860

gacctaggtg gcctgggctg tggcctgaag aacaggtcct cagagggccc cagctcccct     1920

tccgggaagc tcatgagccc caagctgtat gtgtgggcca aagaccgccc tgagatctgg     1980

gagggagagc ctccgtgtct cccaccgagg gacagcctga accagagcct cagccaggac     2040

ctcaccatgg cccctggctc cacactctgg ctgtcctgtg gggtaccccc tgactctgtg     2100

tccaggggcc ccctctcctg gacccatgtg caccccaagg ggcctaagtc attgctgagc     2160

ctagagctga aggacgatcg cccggccaga gatatgtggg taatggagac gggtctgttg     2220

ttgccccggg ccacagctca agacgctgga aagtattatt gtcaccgtgg caacctgacc     2280

atgtcattcc acctggagat cactgctcgg ccagtactat ggcactggct gctgaggact     2340

ggtggctgga aggtctcagc tgtgactttg gcttatctga tcttctgcct gtgttccctt     2400

gtgggcattc ttcatcttca aagagccctg gtcctgagga ggaaaagaaa gcgaatgact     2460

taa                                                                   2463


<210>  282
<211>  2463
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VHVL-CD28H-CD28TM-CD28CS-CD3zICS-T2A-trCD19

<400>  282
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gtccagctgc agcagtctgg gcctgaggtg gtgaggcctg gggtctcagt gaagatttcc      120

tgcaagggtt ccggctacac attcactgat tatggtatac actgggtgaa gcagagtcat      180

gcaaagagtc tagagtggat tggagttatt agtacttaca atggttatac aaactacaac      240

cagaagttta agggcaaggc cacaatgact gtagacaaat cctccagcac agcctatatg      300

gaacttgcca gattgacatc tgaggattct gccatctatt actgtgcaag agcctactat      360

ggtaaccttt actatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      420

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgacat tgtgctgaca      480

cagtctcctg cttccttagc tgtatctctg gggcagaggg ccaccatctc atgcagggcc      540

aacaaaagtg tcagtacatc tagctatagt tatatgcact ggtaccaaca gaaaccagga      600

cagccaccca aactcctcat caagtatgca tccaacctag aatctggggt ccctgccagg      660

ttcagtggca gtgggtctgg gacagacttc atcctcaaca tccatccagt ggaggaggag      720

gatgctgcaa cctattactg tcagcacagt agggagcttc cattcacgtt cggctcgggg      780

acaaagttgg aaataaaagt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgaggagta agaggagcag gctcctgcac      960

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc     1020

tatgccccac cacgcgactt cgcagcctat cgctccctta gagtgaagtt cagcaggagc     1080

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1140

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     1200

aagccgcaga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1260

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1320

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1380

caggccctgc cccctcgcgc cagggccaaa aggtctggct ccggtgaggg cagaggaagt     1440

cttctaacat gcggtgacgt ggaggagaat cccggcccta tgccacctcc tcgcctcctc     1500

ttcttcctcc tcttcctcac ccccatggaa gtcaggcccg aggaacctct agtggtgaag     1560

gtggaagagg gagataacgc tgtgctgcag tgcctcaagg ggacctcaga tggccccact     1620

cagcagctga cctggtctcg ggagtccccg cttaaaccct tcttaaaact cagcctgggg     1680

ctgccaggcc tgggaatcca catgaggccc ctggccatct ggcttttcat cttcaacgtc     1740

tctcaacaga tggggggctt ctacctgtgc cagccggggc ccccctctga gaaggcctgg     1800

cagcctggct ggacagtcaa tgtggagggc agcggggagc tgttccggtg gaatgtttcg     1860

gacctaggtg gcctgggctg tggcctgaag aacaggtcct cagagggccc cagctcccct     1920

tccgggaagc tcatgagccc caagctgtat gtgtgggcca aagaccgccc tgagatctgg     1980

gagggagagc ctccgtgtct cccaccgagg gacagcctga accagagcct cagccaggac     2040

ctcaccatgg cccctggctc cacactctgg ctgtcctgtg gggtaccccc tgactctgtg     2100

tccaggggcc ccctctcctg gacccatgtg caccccaagg ggcctaagtc attgctgagc     2160

ctagagctga aggacgatcg cccggccaga gatatgtggg taatggagac gggtctgttg     2220

ttgccccggg ccacagctca agacgctgga aagtattatt gtcaccgtgg caacctgacc     2280

atgtcattcc acctggagat cactgctcgg ccagtactat ggcactggct gctgaggact     2340

ggtggctgga aggtctcagc tgtgactttg gcttatctga tcttctgcct gtgttccctt     2400

gtgggcattc ttcatcttca aagagccctg gtcctgagga ggaaaagaaa gcgaatgact     2460

taa                                                                   2463


<210>  283
<211>  2463
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VLVH-CD28H-CD28TM-CD28CS-CD3zICS-T2A-trCD19

<400>  283
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagcgac       60

attgtgctga cacagtctcc tgcttcctta gctgtatctc tggggcagag ggccaccatc      120

tcatgcaggg ccaacaaaag tgtcagtaca tctagctata gttatatgca ctggtaccaa      180

cagaaaccag gacagccacc caaactcctc atcaagtatg catccaacct agaatctggg      240

gtccctgcca ggttcagtgg cagtgggtct gggacagact tcatcctcaa catccatcca      300

gtggaggagg aggatgctgc aacctattac tgtcagcaca gtagggagct tccattcacg      360

ttcggctcgg ggacaaagtt ggaaataaaa ggtggtggtg gttctggcgg cggcggctcc      420

ggtggtggtg gttcccaggt ccagctgcag cagtctgggc ctgaggtggt gaggcctggg      480

gtctcagtga agatttcctg caagggttcc ggctacacat tcactgatta tggtatacac      540

tgggtgaagc agagtcatgc aaagagtcta gagtggattg gagttattag tacttacaat      600

ggttatacaa actacaacca gaagtttaag ggcaaggcca caatgactgt agacaaatcc      660

tccagcacag cctatatgga acttgccaga ttgacatctg aggattctgc catctattac      720

tgtgcaagag cctactatgg taacctttac tatgctatgg actactgggg tcaaggaacc      780

tcagtcaccg tctcctcagt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgaggagta agaggagcag gctcctgcac      960

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc     1020

tatgccccac cacgcgactt cgcagcctat cgctccctta gagtgaagtt cagcaggagc     1080

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1140

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     1200

aagccgcaga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1260

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1320

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1380

caggccctgc cccctcgcgc cagggccaaa aggtctggct ccggtgaggg cagaggaagt     1440

cttctaacat gcggtgacgt ggaggagaat cccggcccta tgccacctcc tcgcctcctc     1500

ttcttcctcc tcttcctcac ccccatggaa gtcaggcccg aggaacctct agtggtgaag     1560

gtggaagagg gagataacgc tgtgctgcag tgcctcaagg ggacctcaga tggccccact     1620

cagcagctga cctggtctcg ggagtccccg cttaaaccct tcttaaaact cagcctgggg     1680

ctgccaggcc tgggaatcca catgaggccc ctggccatct ggcttttcat cttcaacgtc     1740

tctcaacaga tggggggctt ctacctgtgc cagccggggc ccccctctga gaaggcctgg     1800

cagcctggct ggacagtcaa tgtggagggc agcggggagc tgttccggtg gaatgtttcg     1860

gacctaggtg gcctgggctg tggcctgaag aacaggtcct cagagggccc cagctcccct     1920

tccgggaagc tcatgagccc caagctgtat gtgtgggcca aagaccgccc tgagatctgg     1980

gagggagagc ctccgtgtct cccaccgagg gacagcctga accagagcct cagccaggac     2040

ctcaccatgg cccctggctc cacactctgg ctgtcctgtg gggtaccccc tgactctgtg     2100

tccaggggcc ccctctcctg gacccatgtg caccccaagg ggcctaagtc attgctgagc     2160

ctagagctga aggacgatcg cccggccaga gatatgtggg taatggagac gggtctgttg     2220

ttgccccggg ccacagctca agacgctgga aagtattatt gtcaccgtgg caacctgacc     2280

atgtcattcc acctggagat cactgctcgg ccagtactat ggcactggct gctgaggact     2340

ggtggctgga aggtctcagc tgtgactttg gcttatctga tcttctgcct gtgttccctt     2400

gtgggcattc ttcatcttca aagagccctg gtcctgagga ggaaaagaaa gcgaatgact     2460

taa                                                                   2463


<210>  284
<211>  2115
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm22.84-CD28H-CD28TM-41BBCS-CD3zICS-T2A-trCD19

<400>  284
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gttcagctgc aagagtctgg cggaggactg gttcaacctg gcggaagcct gagactgtct      120

tgtgccgctt ctggcagaac cttcagcaac tacgtgaact acgccatggg ctggttcaga      180

cagttccccg gcaaagagag agagttcgtc gccagcatca gctggtctag cgtgaccacc      240

tactacgccg acagcgtgaa gggcagattc accatcagca gagacaacgc caagaacacc      300

gtgtacctgc agatgaacag cctgaagcca gaggacaccg ccgtgtacta ctgtgctgct      360

cacctggctc agtacagcga ctacgcctac agagatcccc accagtttgg cgcttggggc      420

cagggaacac aagtgaccgt tagctctgtg aaagggaaac acctttgtcc aagtccccta      480

tttcccggac cttctaagcc cttttgggtg ctggtggtgg ttggtggagt cctggcttgc      540

tatagcttgc tagtaacagt ggcctttatt attttctggg tgaaacgggg cagaaagaaa      600

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat      660

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgct tagagtgaag      720

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag      780

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct      840

gagatggggg gaaagccgca gagaaggaag aaccctcagg aaggcctgta caatgaactg      900

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg      960

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1020

gcccttcaca tgcaggccct gccccctcgc gccagggcca aaaggtctgg ctccggtgag     1080

ggcagaggaa gtcttctaac atgcggtgac gtggaggaga atcccggccc tatgccacct     1140

cctcgcctcc tcttcttcct cctcttcctc acccccatgg aagtcaggcc cgaggaacct     1200

ctagtggtga aggtggaaga gggagataac gctgtgctgc agtgcctcaa ggggacctca     1260

gatggcccca ctcagcagct gacctggtct cgggagtccc cgcttaaacc cttcttaaaa     1320

ctcagcctgg ggctgccagg cctgggaatc cacatgaggc ccctggccat ctggcttttc     1380

atcttcaacg tctctcaaca gatggggggc ttctacctgt gccagccggg gcccccctct     1440

gagaaggcct ggcagcctgg ctggacagtc aatgtggagg gcagcgggga gctgttccgg     1500

tggaatgttt cggacctagg tggcctgggc tgtggcctga agaacaggtc ctcagagggc     1560

cccagctccc cttccgggaa gctcatgagc cccaagctgt atgtgtgggc caaagaccgc     1620

cctgagatct gggagggaga gcctccgtgt ctcccaccga gggacagcct gaaccagagc     1680

ctcagccagg acctcaccat ggcccctggc tccacactct ggctgtcctg tggggtaccc     1740

cctgactctg tgtccagggg ccccctctcc tggacccatg tgcaccccaa ggggcctaag     1800

tcattgctga gcctagagct gaaggacgat cgcccggcca gagatatgtg ggtaatggag     1860

acgggtctgt tgttgccccg ggccacagct caagacgctg gaaagtatta ttgtcaccgt     1920

ggcaacctga ccatgtcatt ccacctggag atcactgctc ggccagtact atggcactgg     1980

ctgctgagga ctggtggctg gaaggtctca gctgtgactt tggcttatct gatcttctgc     2040

ctgtgttccc ttgtgggcat tcttcatctt caaagagccc tggtcctgag gaggaaaaga     2100

aagcgaatga cttaa                                                      2115


<210>  285
<211>  2118
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm5.38-CD28H-CD28TM-41BBCS-CD3zICS-T2A-trCD19

<400>  285
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gttcagctgc aagagtctgg cggaggactg gttcaagctg gcggaagcct gagactgtct      120

tgtgccgctt ctggcttcac cgacgacgac tacgatatcg gctggttcag acaggcccct      180

ggcaaagaga gagagggcgt cagctgtatc agcagctctg acggctctac ctactacgcc      240

gacagcgtga agggcagatt caccatcagc agcgacaacg ccaagaacac cgtgtacctg      300

cagatgaact ctctgaagcc cgaggacacc gccgtgtact actgtgccgc cgacttcttc      360

agatgggaca gcggcagcta ctacgtgcgg ggatgtagac acgccaccta cgattactgg      420

ggccagggca cacaagtgac cgtgtcatct gtgaaaggga aacacctttg tccaagtccc      480

ctatttcccg gaccttctaa gcccttttgg gtgctggtgg tggttggtgg agtcctggct      540

tgctatagct tgctagtaac agtggccttt attattttct gggtgaaacg gggcagaaag      600

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa      660

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gcttagagtg      720

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac      780

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac      840

cctgagatgg ggggaaagcc gcagagaagg aagaaccctc aggaaggcct gtacaatgaa      900

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg      960

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     1020

gacgcccttc acatgcaggc cctgccccct cgcgccaggg ccaaaaggtc tggctccggt     1080

gagggcagag gaagtcttct aacatgcggt gacgtggagg agaatcccgg ccctatgcca     1140

cctcctcgcc tcctcttctt cctcctcttc ctcaccccca tggaagtcag gcccgaggaa     1200

cctctagtgg tgaaggtgga agagggagat aacgctgtgc tgcagtgcct caaggggacc     1260

tcagatggcc ccactcagca gctgacctgg tctcgggagt ccccgcttaa acccttctta     1320

aaactcagcc tggggctgcc aggcctggga atccacatga ggcccctggc catctggctt     1380

ttcatcttca acgtctctca acagatgggg ggcttctacc tgtgccagcc ggggcccccc     1440

tctgagaagg cctggcagcc tggctggaca gtcaatgtgg agggcagcgg ggagctgttc     1500

cggtggaatg tttcggacct aggtggcctg ggctgtggcc tgaagaacag gtcctcagag     1560

ggccccagct ccccttccgg gaagctcatg agccccaagc tgtatgtgtg ggccaaagac     1620

cgccctgaga tctgggaggg agagcctccg tgtctcccac cgagggacag cctgaaccag     1680

agcctcagcc aggacctcac catggcccct ggctccacac tctggctgtc ctgtggggta     1740

ccccctgact ctgtgtccag gggccccctc tcctggaccc atgtgcaccc caaggggcct     1800

aagtcattgc tgagcctaga gctgaaggac gatcgcccgg ccagagatat gtgggtaatg     1860

gagacgggtc tgttgttgcc ccgggccaca gctcaagacg ctggaaagta ttattgtcac     1920

cgtggcaacc tgaccatgtc attccacctg gagatcactg ctcggccagt actatggcac     1980

tggctgctga ggactggtgg ctggaaggtc tcagctgtga ctttggctta tctgatcttc     2040

tgcctgtgtt cccttgtggg cattcttcat cttcaaagag ccctggtcct gaggaggaaa     2100

agaaagcgaa tgacttaa                                                   2118


<210>  286
<211>  2466
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VHVL-CD28H-CD28TM-41BBCS-CD3zICS-T2A-trCD19

<400>  286
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gtccagctgc agcagtctgg gcctgaggtg gtgaggcctg gggtctcagt gaagatttcc      120

tgcaagggtt ccggctacac attcactgat tatggtatgc actgggtgaa gcagagtcat      180

gcaaagagtc tagagtggat tggagttatt agtacttaca atggttatac aaactacaac      240

cagaagttta agggcaaggc cacaatgact gtagacaaat cctccagcac agcctatatg      300

gaacttgcca gattgacatc tgaggattct gccatctatt actgtgcaag agcctactat      360

ggtaaccttt actatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      420

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgacat tgtgctgaca      480

cagtctcctg cttccttagc tgtatctctg gggcagaggg ccaccatctc atgcagggcc      540

agcaaaagtg tcagtacatc tagctatagt tatatgcact ggtaccaaca gaaaccagga      600

cagccaccca aactcctcat caagtatgca tccaacctag aatctggggt ccctgccagg      660

ttcagtggca gtgggtctgg gacagacttc atcctcaaca tccatccagt ggaggaggag      720

gatgctgcaa cctattactg tcagcacagt agggagcttc cattcacgtt cggctcgggg      780

acaaagttgg aaataaaagt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgaaacggg gcagaaagaa actcctgtat      960

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     1020

tgccgatttc cagaagaaga agaaggagga tgtgaactgc ttagagtgaa gttcagcagg     1080

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1140

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1200

ggaaagccgc agagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1260

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1320

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1380

atgcaggccc tgccccctcg cgccagggcc aaaaggtctg gctccggtga gggcagagga     1440

agtcttctaa catgcggtga cgtggaggag aatcccggcc ctatgccacc tcctcgcctc     1500

ctcttcttcc tcctcttcct cacccccatg gaagtcaggc ccgaggaacc tctagtggtg     1560

aaggtggaag agggagataa cgctgtgctg cagtgcctca aggggacctc agatggcccc     1620

actcagcagc tgacctggtc tcgggagtcc ccgcttaaac ccttcttaaa actcagcctg     1680

gggctgccag gcctgggaat ccacatgagg cccctggcca tctggctttt catcttcaac     1740

gtctctcaac agatgggggg cttctacctg tgccagccgg ggcccccctc tgagaaggcc     1800

tggcagcctg gctggacagt caatgtggag ggcagcgggg agctgttccg gtggaatgtt     1860

tcggacctag gtggcctggg ctgtggcctg aagaacaggt cctcagaggg ccccagctcc     1920

ccttccggga agctcatgag ccccaagctg tatgtgtggg ccaaagaccg ccctgagatc     1980

tgggagggag agcctccgtg tctcccaccg agggacagcc tgaaccagag cctcagccag     2040

gacctcacca tggcccctgg ctccacactc tggctgtcct gtggggtacc ccctgactct     2100

gtgtccaggg gccccctctc ctggacccat gtgcacccca aggggcctaa gtcattgctg     2160

agcctagagc tgaaggacga tcgcccggcc agagatatgt gggtaatgga gacgggtctg     2220

ttgttgcccc gggccacagc tcaagacgct ggaaagtatt attgtcaccg tggcaacctg     2280

accatgtcat tccacctgga gatcactgct cggccagtac tatggcactg gctgctgagg     2340

actggtggct ggaaggtctc agctgtgact ttggcttatc tgatcttctg cctgtgttcc     2400

cttgtgggca ttcttcatct tcaaagagcc ctggtcctga ggaggaaaag aaagcgaatg     2460

acttaa                                                                2466


<210>  287
<211>  2466
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VLVH-CD28H-CD28TM-41BBCS-CD3zICS-T2A-trCD19

<400>  287
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagcgac       60

attgtgctga cacagtctcc tgcttcctta gctgtatctc tggggcagag ggccaccatc      120

tcatgcaggg ccagcaaaag tgtcagtaca tctagctata gttatatgca ctggtaccaa      180

cagaaaccag gacagccacc caaactcctc atcaagtatg catccaacct agaatctggg      240

gtccctgcca ggttcagtgg cagtgggtct gggacagact tcatcctcaa catccatcca      300

gtggaggagg aggatgctgc aacctattac tgtcagcaca gtagggagct tccattcacg      360

ttcggctcgg ggacaaagtt ggaaataaaa ggtggtggtg gttctggcgg cggcggctcc      420

ggtggtggtg gttcccaggt ccagctgcag cagtctgggc ctgaggtggt gaggcctggg      480

gtctcagtga agatttcctg caagggttcc ggctacacat tcactgatta tggtatgcac      540

tgggtgaagc agagtcatgc aaagagtcta gagtggattg gagttattag tacttacaat      600

ggttatacaa actacaacca gaagtttaag ggcaaggcca caatgactgt agacaaatcc      660

tccagcacag cctatatgga acttgccaga ttgacatctg aggattctgc catctattac      720

tgtgcaagag cctactatgg taacctttac tatgctatgg actactgggg tcaaggaacc      780

tcagtcaccg tctcctcagt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgaaacggg gcagaaagaa actcctgtat      960

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     1020

tgccgatttc cagaagaaga agaaggagga tgtgaactgc ttagagtgaa gttcagcagg     1080

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1140

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1200

ggaaagccgc agagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1260

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1320

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1380

atgcaggccc tgccccctcg cgccagggcc aaaaggtctg gctccggtga gggcagagga     1440

agtcttctaa catgcggtga cgtggaggag aatcccggcc ctatgccacc tcctcgcctc     1500

ctcttcttcc tcctcttcct cacccccatg gaagtcaggc ccgaggaacc tctagtggtg     1560

aaggtggaag agggagataa cgctgtgctg cagtgcctca aggggacctc agatggcccc     1620

actcagcagc tgacctggtc tcgggagtcc ccgcttaaac ccttcttaaa actcagcctg     1680

gggctgccag gcctgggaat ccacatgagg cccctggcca tctggctttt catcttcaac     1740

gtctctcaac agatgggggg cttctacctg tgccagccgg ggcccccctc tgagaaggcc     1800

tggcagcctg gctggacagt caatgtggag ggcagcgggg agctgttccg gtggaatgtt     1860

tcggacctag gtggcctggg ctgtggcctg aagaacaggt cctcagaggg ccccagctcc     1920

ccttccggga agctcatgag ccccaagctg tatgtgtggg ccaaagaccg ccctgagatc     1980

tgggagggag agcctccgtg tctcccaccg agggacagcc tgaaccagag cctcagccag     2040

gacctcacca tggcccctgg ctccacactc tggctgtcct gtggggtacc ccctgactct     2100

gtgtccaggg gccccctctc ctggacccat gtgcacccca aggggcctaa gtcattgctg     2160

agcctagagc tgaaggacga tcgcccggcc agagatatgt gggtaatgga gacgggtctg     2220

ttgttgcccc gggccacagc tcaagacgct ggaaagtatt attgtcaccg tggcaacctg     2280

accatgtcat tccacctgga gatcactgct cggccagtac tatggcactg gctgctgagg     2340

actggtggct ggaaggtctc agctgtgact ttggcttatc tgatcttctg cctgtgttcc     2400

cttgtgggca ttcttcatct tcaaagagcc ctggtcctga ggaggaaaag aaagcgaatg     2460

acttaa                                                                2466


<210>  288
<211>  2466
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VHVL-CD28H-CD28TM-41BBCS-CD3zICS-T2A-trCD19

<400>  288
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gtccagctgc agcagtctgg gcctgaggtg gtgaggcctg gggtctcagt gaagatttcc      120

tgcaagggtt ccggctacac attcactgat tatggtatac actgggtgaa gcagagtcat      180

gcaaagagtc tagagtggat tggagttatt agtacttaca atggttatac aaactacaac      240

cagaagttta agggcaaggc cacaatgact gtagacaaat cctccagcac agcctatatg      300

gaacttgcca gattgacatc tgaggattct gccatctatt actgtgcaag agcctactat      360

ggtaaccttt actatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      420

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgacat tgtgctgaca      480

cagtctcctg cttccttagc tgtatctctg gggcagaggg ccaccatctc atgcagggcc      540

aacaaaagtg tcagtacatc tagctatagt tatatgcact ggtaccaaca gaaaccagga      600

cagccaccca aactcctcat caagtatgca tccaacctag aatctggggt ccctgccagg      660

ttcagtggca gtgggtctgg gacagacttc atcctcaaca tccatccagt ggaggaggag      720

gatgctgcaa cctattactg tcagcacagt agggagcttc cattcacgtt cggctcgggg      780

acaaagttgg aaataaaagt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgaaacggg gcagaaagaa actcctgtat      960

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     1020

tgccgatttc cagaagaaga agaaggagga tgtgaactgc ttagagtgaa gttcagcagg     1080

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1140

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1200

ggaaagccgc agagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1260

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1320

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1380

atgcaggccc tgccccctcg cgccagggcc aaaaggtctg gctccggtga gggcagagga     1440

agtcttctaa catgcggtga cgtggaggag aatcccggcc ctatgccacc tcctcgcctc     1500

ctcttcttcc tcctcttcct cacccccatg gaagtcaggc ccgaggaacc tctagtggtg     1560

aaggtggaag agggagataa cgctgtgctg cagtgcctca aggggacctc agatggcccc     1620

actcagcagc tgacctggtc tcgggagtcc ccgcttaaac ccttcttaaa actcagcctg     1680

gggctgccag gcctgggaat ccacatgagg cccctggcca tctggctttt catcttcaac     1740

gtctctcaac agatgggggg cttctacctg tgccagccgg ggcccccctc tgagaaggcc     1800

tggcagcctg gctggacagt caatgtggag ggcagcgggg agctgttccg gtggaatgtt     1860

tcggacctag gtggcctggg ctgtggcctg aagaacaggt cctcagaggg ccccagctcc     1920

ccttccggga agctcatgag ccccaagctg tatgtgtggg ccaaagaccg ccctgagatc     1980

tgggagggag agcctccgtg tctcccaccg agggacagcc tgaaccagag cctcagccag     2040

gacctcacca tggcccctgg ctccacactc tggctgtcct gtggggtacc ccctgactct     2100

gtgtccaggg gccccctctc ctggacccat gtgcacccca aggggcctaa gtcattgctg     2160

agcctagagc tgaaggacga tcgcccggcc agagatatgt gggtaatgga gacgggtctg     2220

ttgttgcccc gggccacagc tcaagacgct ggaaagtatt attgtcaccg tggcaacctg     2280

accatgtcat tccacctgga gatcactgct cggccagtac tatggcactg gctgctgagg     2340

actggtggct ggaaggtctc agctgtgact ttggcttatc tgatcttctg cctgtgttcc     2400

cttgtgggca ttcttcatct tcaaagagcc ctggtcctga ggaggaaaag aaagcgaatg     2460

acttaa                                                                2466


<210>  289
<211>  2466
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VLVH-CD28H-CD28TM-41BBCS-CD3zICS-T2A-trCD19

<400>  289
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagcgac       60

attgtgctga cacagtctcc tgcttcctta gctgtatctc tggggcagag ggccaccatc      120

tcatgcaggg ccaacaaaag tgtcagtaca tctagctata gttatatgca ctggtaccaa      180

cagaaaccag gacagccacc caaactcctc atcaagtatg catccaacct agaatctggg      240

gtccctgcca ggttcagtgg cagtgggtct gggacagact tcatcctcaa catccatcca      300

gtggaggagg aggatgctgc aacctattac tgtcagcaca gtagggagct tccattcacg      360

ttcggctcgg ggacaaagtt ggaaataaaa ggtggtggtg gttctggcgg cggcggctcc      420

ggtggtggtg gttcccaggt ccagctgcag cagtctgggc ctgaggtggt gaggcctggg      480

gtctcagtga agatttcctg caagggttcc ggctacacat tcactgatta tggtatacac      540

tgggtgaagc agagtcatgc aaagagtcta gagtggattg gagttattag tacttacaat      600

ggttatacaa actacaacca gaagtttaag ggcaaggcca caatgactgt agacaaatcc      660

tccagcacag cctatatgga acttgccaga ttgacatctg aggattctgc catctattac      720

tgtgcaagag cctactatgg taacctttac tatgctatgg actactgggg tcaaggaacc      780

tcagtcaccg tctcctcagt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgaaacggg gcagaaagaa actcctgtat      960

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     1020

tgccgatttc cagaagaaga agaaggagga tgtgaactgc ttagagtgaa gttcagcagg     1080

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1140

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1200

ggaaagccgc agagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1260

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1320

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1380

atgcaggccc tgccccctcg cgccagggcc aaaaggtctg gctccggtga gggcagagga     1440

agtcttctaa catgcggtga cgtggaggag aatcccggcc ctatgccacc tcctcgcctc     1500

ctcttcttcc tcctcttcct cacccccatg gaagtcaggc ccgaggaacc tctagtggtg     1560

aaggtggaag agggagataa cgctgtgctg cagtgcctca aggggacctc agatggcccc     1620

actcagcagc tgacctggtc tcgggagtcc ccgcttaaac ccttcttaaa actcagcctg     1680

gggctgccag gcctgggaat ccacatgagg cccctggcca tctggctttt catcttcaac     1740

gtctctcaac agatgggggg cttctacctg tgccagccgg ggcccccctc tgagaaggcc     1800

tggcagcctg gctggacagt caatgtggag ggcagcgggg agctgttccg gtggaatgtt     1860

tcggacctag gtggcctggg ctgtggcctg aagaacaggt cctcagaggg ccccagctcc     1920

ccttccggga agctcatgag ccccaagctg tatgtgtggg ccaaagaccg ccctgagatc     1980

tgggagggag agcctccgtg tctcccaccg agggacagcc tgaaccagag cctcagccag     2040

gacctcacca tggcccctgg ctccacactc tggctgtcct gtggggtacc ccctgactct     2100

gtgtccaggg gccccctctc ctggacccat gtgcacccca aggggcctaa gtcattgctg     2160

agcctagagc tgaaggacga tcgcccggcc agagatatgt gggtaatgga gacgggtctg     2220

ttgttgcccc gggccacagc tcaagacgct ggaaagtatt attgtcaccg tggcaacctg     2280

accatgtcat tccacctgga gatcactgct cggccagtac tatggcactg gctgctgagg     2340

actggtggct ggaaggtctc agctgtgact ttggcttatc tgatcttctg cctgtgttcc     2400

cttgtgggca ttcttcatct tcaaagagcc ctggtcctga ggaggaaaag aaagcgaatg     2460

acttaa                                                                2466


<210>  290
<211>  2061
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm22.84-CD28H-CD28TM-DAP10CS-CD3zICS-T2A-trCD19

<400>  290
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gttcagctgc aagagtctgg cggaggactg gttcaacctg gcggaagcct gagactgtct      120

tgtgccgctt ctggcagaac cttcagcaac tacgtgaact acgccatggg ctggttcaga      180

cagttccccg gcaaagagag agagttcgtc gccagcatca gctggtctag cgtgaccacc      240

tactacgccg acagcgtgaa gggcagattc accatcagca gagacaacgc caagaacacc      300

gtgtacctgc agatgaacag cctgaagcca gaggacaccg ccgtgtacta ctgtgctgct      360

cacctggctc agtacagcga ctacgcctac agagatcccc accagtttgg cgcttggggc      420

cagggaacac aagtgaccgt tagctctgtg aaagggaaac acctttgtcc aagtccccta      480

tttcccggac cttctaagcc cttttgggtg ctggtggtgg ttggtggagt cctggcttgc      540

tatagcttgc tagtaacagt ggcctttatt attttctggg tgctgtgcgc acgcccacgc      600

cgcagccccg cccaagaaga tggcaaagtc tacatcaaca tgccaggcag gggccttaga      660

gtgaagttca gcaggagcgc agacgccccc gcgtaccagc agggccagaa ccagctctat      720

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg      780

gaccctgaga tggggggaaa gccgcagaga aggaagaacc ctcaggaagg cctgtacaat      840

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      900

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      960

tacgacgccc ttcacatgca ggccctgccc cctcgcgcca gggccaaaag gtctggctcc     1020

ggtgagggca gaggaagtct tctaacatgc ggtgacgtgg aggagaatcc cggccctatg     1080

ccacctcctc gcctcctctt cttcctcctc ttcctcaccc ccatggaagt caggcccgag     1140

gaacctctag tggtgaaggt ggaagaggga gataacgctg tgctgcagtg cctcaagggg     1200

acctcagatg gccccactca gcagctgacc tggtctcggg agtccccgct taaacccttc     1260

ttaaaactca gcctggggct gccaggcctg ggaatccaca tgaggcccct ggccatctgg     1320

cttttcatct tcaacgtctc tcaacagatg gggggcttct acctgtgcca gccggggccc     1380

ccctctgaga aggcctggca gcctggctgg acagtcaatg tggagggcag cggggagctg     1440

ttccggtgga atgtttcgga cctaggtggc ctgggctgtg gcctgaagaa caggtcctca     1500

gagggcccca gctccccttc cgggaagctc atgagcccca agctgtatgt gtgggccaaa     1560

gaccgccctg agatctggga gggagagcct ccgtgtctcc caccgaggga cagcctgaac     1620

cagagcctca gccaggacct caccatggcc cctggctcca cactctggct gtcctgtggg     1680

gtaccccctg actctgtgtc caggggcccc ctctcctgga cccatgtgca ccccaagggg     1740

cctaagtcat tgctgagcct agagctgaag gacgatcgcc cggccagaga tatgtgggta     1800

atggagacgg gtctgttgtt gccccgggcc acagctcaag acgctggaaa gtattattgt     1860

caccgtggca acctgaccat gtcattccac ctggagatca ctgctcggcc agtactatgg     1920

cactggctgc tgaggactgg tggctggaag gtctcagctg tgactttggc ttatctgatc     1980

ttctgcctgt gttcccttgt gggcattctt catcttcaaa gagccctggt cctgaggagg     2040

aaaagaaagc gaatgactta a                                               2061


<210>  291
<211>  2064
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm5.38-CD28H-CD28TM-DAP10CS-CD3zICS-T2A-trCD19

<400>  291
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gttcagctgc aagagtctgg cggaggactg gttcaagctg gcggaagcct gagactgtct      120

tgtgccgctt ctggcttcac cgacgacgac tacgatatcg gctggttcag acaggcccct      180

ggcaaagaga gagagggcgt cagctgtatc agcagctctg acggctctac ctactacgcc      240

gacagcgtga agggcagatt caccatcagc agcgacaacg ccaagaacac cgtgtacctg      300

cagatgaact ctctgaagcc cgaggacacc gccgtgtact actgtgccgc cgacttcttc      360

agatgggaca gcggcagcta ctacgtgcgg ggatgtagac acgccaccta cgattactgg      420

ggccagggca cacaagtgac cgtgtcatct gtgaaaggga aacacctttg tccaagtccc      480

ctatttcccg gaccttctaa gcccttttgg gtgctggtgg tggttggtgg agtcctggct      540

tgctatagct tgctagtaac agtggccttt attattttct gggtgctgtg cgcacgccca      600

cgccgcagcc ccgcccaaga agatggcaaa gtctacatca acatgccagg caggggcctt      660

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc      720

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      780

cgggaccctg agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac      840

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag      900

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac      960

acctacgacg cccttcacat gcaggccctg ccccctcgcg ccagggccaa aaggtctggc     1020

tccggtgagg gcagaggaag tcttctaaca tgcggtgacg tggaggagaa tcccggccct     1080

atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc     1140

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag     1200

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc     1260

ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggccatc     1320

tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg     1380

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag     1440

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc     1500

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc     1560

aaagaccgcc ctgagatctg ggagggagag cctccgtgtc tcccaccgag ggacagcctg     1620

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt     1680

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag     1740

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg     1800

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat     1860

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta     1920

tggcactggc tgctgaggac tggtggctgg aaggtctcag ctgtgacttt ggcttatctg     1980

atcttctgcc tgtgttccct tgtgggcatt cttcatcttc aaagagccct ggtcctgagg     2040

aggaaaagaa agcgaatgac ttaa                                            2064


<210>  292
<211>  2412
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VHVL-CD28H-CD28TM-DAP10CS-CD3zICS-T2A-trCD19

<400>  292
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gtccagctgc agcagtctgg gcctgaggtg gtgaggcctg gggtctcagt gaagatttcc      120

tgcaagggtt ccggctacac attcactgat tatggtatgc actgggtgaa gcagagtcat      180

gcaaagagtc tagagtggat tggagttatt agtacttaca atggttatac aaactacaac      240

cagaagttta agggcaaggc cacaatgact gtagacaaat cctccagcac agcctatatg      300

gaacttgcca gattgacatc tgaggattct gccatctatt actgtgcaag agcctactat      360

ggtaaccttt actatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      420

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgacat tgtgctgaca      480

cagtctcctg cttccttagc tgtatctctg gggcagaggg ccaccatctc atgcagggcc      540

agcaaaagtg tcagtacatc tagctatagt tatatgcact ggtaccaaca gaaaccagga      600

cagccaccca aactcctcat caagtatgca tccaacctag aatctggggt ccctgccagg      660

ttcagtggca gtgggtctgg gacagacttc atcctcaaca tccatccagt ggaggaggag      720

gatgctgcaa cctattactg tcagcacagt agggagcttc cattcacgtt cggctcgggg      780

acaaagttgg aaataaaagt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgctgtgcg cacgcccacg ccgcagcccc      960

gcccaagaag atggcaaagt ctacatcaac atgccaggca ggggccttag agtgaagttc     1020

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc     1080

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1140

atggggggaa agccgcagag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1200

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1260

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1320

cttcacatgc aggccctgcc ccctcgcgcc agggccaaaa ggtctggctc cggtgagggc     1380

agaggaagtc ttctaacatg cggtgacgtg gaggagaatc ccggccctat gccacctcct     1440

cgcctcctct tcttcctcct cttcctcacc cccatggaag tcaggcccga ggaacctcta     1500

gtggtgaagg tggaagaggg agataacgct gtgctgcagt gcctcaaggg gacctcagat     1560

ggccccactc agcagctgac ctggtctcgg gagtccccgc ttaaaccctt cttaaaactc     1620

agcctggggc tgccaggcct gggaatccac atgaggcccc tggccatctg gcttttcatc     1680

ttcaacgtct ctcaacagat ggggggcttc tacctgtgcc agccggggcc cccctctgag     1740

aaggcctggc agcctggctg gacagtcaat gtggagggca gcggggagct gttccggtgg     1800

aatgtttcgg acctaggtgg cctgggctgt ggcctgaaga acaggtcctc agagggcccc     1860

agctcccctt ccgggaagct catgagcccc aagctgtatg tgtgggccaa agaccgccct     1920

gagatctggg agggagagcc tccgtgtctc ccaccgaggg acagcctgaa ccagagcctc     1980

agccaggacc tcaccatggc ccctggctcc acactctggc tgtcctgtgg ggtaccccct     2040

gactctgtgt ccaggggccc cctctcctgg acccatgtgc accccaaggg gcctaagtca     2100

ttgctgagcc tagagctgaa ggacgatcgc ccggccagag atatgtgggt aatggagacg     2160

ggtctgttgt tgccccgggc cacagctcaa gacgctggaa agtattattg tcaccgtggc     2220

aacctgacca tgtcattcca cctggagatc actgctcggc cagtactatg gcactggctg     2280

ctgaggactg gtggctggaa ggtctcagct gtgactttgg cttatctgat cttctgcctg     2340

tgttcccttg tgggcattct tcatcttcaa agagccctgg tcctgaggag gaaaagaaag     2400

cgaatgactt aa                                                         2412


<210>  293
<211>  2412
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VLVH-CD28H-CD28TM-DAP10CS-CD3zICS-T2A-trCD19

<400>  293
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagcgac       60

attgtgctga cacagtctcc tgcttcctta gctgtatctc tggggcagag ggccaccatc      120

tcatgcaggg ccagcaaaag tgtcagtaca tctagctata gttatatgca ctggtaccaa      180

cagaaaccag gacagccacc caaactcctc atcaagtatg catccaacct agaatctggg      240

gtccctgcca ggttcagtgg cagtgggtct gggacagact tcatcctcaa catccatcca      300

gtggaggagg aggatgctgc aacctattac tgtcagcaca gtagggagct tccattcacg      360

ttcggctcgg ggacaaagtt ggaaataaaa ggtggtggtg gttctggcgg cggcggctcc      420

ggtggtggtg gttcccaggt ccagctgcag cagtctgggc ctgaggtggt gaggcctggg      480

gtctcagtga agatttcctg caagggttcc ggctacacat tcactgatta tggtatgcac      540

tgggtgaagc agagtcatgc aaagagtcta gagtggattg gagttattag tacttacaat      600

ggttatacaa actacaacca gaagtttaag ggcaaggcca caatgactgt agacaaatcc      660

tccagcacag cctatatgga acttgccaga ttgacatctg aggattctgc catctattac      720

tgtgcaagag cctactatgg taacctttac tatgctatgg actactgggg tcaaggaacc      780

tcagtcaccg tctcctcagt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgctgtgcg cacgcccacg ccgcagcccc      960

gcccaagaag atggcaaagt ctacatcaac atgccaggca ggggccttag agtgaagttc     1020

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc     1080

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1140

atggggggaa agccgcagag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1200

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1260

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1320

cttcacatgc aggccctgcc ccctcgcgcc agggccaaaa ggtctggctc cggtgagggc     1380

agaggaagtc ttctaacatg cggtgacgtg gaggagaatc ccggccctat gccacctcct     1440

cgcctcctct tcttcctcct cttcctcacc cccatggaag tcaggcccga ggaacctcta     1500

gtggtgaagg tggaagaggg agataacgct gtgctgcagt gcctcaaggg gacctcagat     1560

ggccccactc agcagctgac ctggtctcgg gagtccccgc ttaaaccctt cttaaaactc     1620

agcctggggc tgccaggcct gggaatccac atgaggcccc tggccatctg gcttttcatc     1680

ttcaacgtct ctcaacagat ggggggcttc tacctgtgcc agccggggcc cccctctgag     1740

aaggcctggc agcctggctg gacagtcaat gtggagggca gcggggagct gttccggtgg     1800

aatgtttcgg acctaggtgg cctgggctgt ggcctgaaga acaggtcctc agagggcccc     1860

agctcccctt ccgggaagct catgagcccc aagctgtatg tgtgggccaa agaccgccct     1920

gagatctggg agggagagcc tccgtgtctc ccaccgaggg acagcctgaa ccagagcctc     1980

agccaggacc tcaccatggc ccctggctcc acactctggc tgtcctgtgg ggtaccccct     2040

gactctgtgt ccaggggccc cctctcctgg acccatgtgc accccaaggg gcctaagtca     2100

ttgctgagcc tagagctgaa ggacgatcgc ccggccagag atatgtgggt aatggagacg     2160

ggtctgttgt tgccccgggc cacagctcaa gacgctggaa agtattattg tcaccgtggc     2220

aacctgacca tgtcattcca cctggagatc actgctcggc cagtactatg gcactggctg     2280

ctgaggactg gtggctggaa ggtctcagct gtgactttgg cttatctgat cttctgcctg     2340

tgttcccttg tgggcattct tcatcttcaa agagccctgg tcctgaggag gaaaagaaag     2400

cgaatgactt aa                                                         2412


<210>  294
<211>  2412
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VHVL-CD28H-CD28TM-DAP10CS-CD3zICS-T2A-trCD19

<400>  294
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gtccagctgc agcagtctgg gcctgaggtg gtgaggcctg gggtctcagt gaagatttcc      120

tgcaagggtt ccggctacac attcactgat tatggtatac actgggtgaa gcagagtcat      180

gcaaagagtc tagagtggat tggagttatt agtacttaca atggttatac aaactacaac      240

cagaagttta agggcaaggc cacaatgact gtagacaaat cctccagcac agcctatatg      300

gaacttgcca gattgacatc tgaggattct gccatctatt actgtgcaag agcctactat      360

ggtaaccttt actatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      420

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgacat tgtgctgaca      480

cagtctcctg cttccttagc tgtatctctg gggcagaggg ccaccatctc atgcagggcc      540

aacaaaagtg tcagtacatc tagctatagt tatatgcact ggtaccaaca gaaaccagga      600

cagccaccca aactcctcat caagtatgca tccaacctag aatctggggt ccctgccagg      660

ttcagtggca gtgggtctgg gacagacttc atcctcaaca tccatccagt ggaggaggag      720

gatgctgcaa cctattactg tcagcacagt agggagcttc cattcacgtt cggctcgggg      780

acaaagttgg aaataaaagt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgctgtgcg cacgcccacg ccgcagcccc      960

gcccaagaag atggcaaagt ctacatcaac atgccaggca ggggccttag agtgaagttc     1020

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc     1080

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1140

atggggggaa agccgcagag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1200

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1260

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1320

cttcacatgc aggccctgcc ccctcgcgcc agggccaaaa ggtctggctc cggtgagggc     1380

agaggaagtc ttctaacatg cggtgacgtg gaggagaatc ccggccctat gccacctcct     1440

cgcctcctct tcttcctcct cttcctcacc cccatggaag tcaggcccga ggaacctcta     1500

gtggtgaagg tggaagaggg agataacgct gtgctgcagt gcctcaaggg gacctcagat     1560

ggccccactc agcagctgac ctggtctcgg gagtccccgc ttaaaccctt cttaaaactc     1620

agcctggggc tgccaggcct gggaatccac atgaggcccc tggccatctg gcttttcatc     1680

ttcaacgtct ctcaacagat ggggggcttc tacctgtgcc agccggggcc cccctctgag     1740

aaggcctggc agcctggctg gacagtcaat gtggagggca gcggggagct gttccggtgg     1800

aatgtttcgg acctaggtgg cctgggctgt ggcctgaaga acaggtcctc agagggcccc     1860

agctcccctt ccgggaagct catgagcccc aagctgtatg tgtgggccaa agaccgccct     1920

gagatctggg agggagagcc tccgtgtctc ccaccgaggg acagcctgaa ccagagcctc     1980

agccaggacc tcaccatggc ccctggctcc acactctggc tgtcctgtgg ggtaccccct     2040

gactctgtgt ccaggggccc cctctcctgg acccatgtgc accccaaggg gcctaagtca     2100

ttgctgagcc tagagctgaa ggacgatcgc ccggccagag atatgtgggt aatggagacg     2160

ggtctgttgt tgccccgggc cacagctcaa gacgctggaa agtattattg tcaccgtggc     2220

aacctgacca tgtcattcca cctggagatc actgctcggc cagtactatg gcactggctg     2280

ctgaggactg gtggctggaa ggtctcagct gtgactttgg cttatctgat cttctgcctg     2340

tgttcccttg tgggcattct tcatcttcaa agagccctgg tcctgaggag gaaaagaaag     2400

cgaatgactt aa                                                         2412


<210>  295
<211>  2412
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VLVH-CD28H-CD28TM-DAP10CS-CD3zICS-T2A-trCD19

<400>  295
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagcgac       60

attgtgctga cacagtctcc tgcttcctta gctgtatctc tggggcagag ggccaccatc      120

tcatgcaggg ccaacaaaag tgtcagtaca tctagctata gttatatgca ctggtaccaa      180

cagaaaccag gacagccacc caaactcctc atcaagtatg catccaacct agaatctggg      240

gtccctgcca ggttcagtgg cagtgggtct gggacagact tcatcctcaa catccatcca      300

gtggaggagg aggatgctgc aacctattac tgtcagcaca gtagggagct tccattcacg      360

ttcggctcgg ggacaaagtt ggaaataaaa ggtggtggtg gttctggcgg cggcggctcc      420

ggtggtggtg gttcccaggt ccagctgcag cagtctgggc ctgaggtggt gaggcctggg      480

gtctcagtga agatttcctg caagggttcc ggctacacat tcactgatta tggtatacac      540

tgggtgaagc agagtcatgc aaagagtcta gagtggattg gagttattag tacttacaat      600

ggttatacaa actacaacca gaagtttaag ggcaaggcca caatgactgt agacaaatcc      660

tccagcacag cctatatgga acttgccaga ttgacatctg aggattctgc catctattac      720

tgtgcaagag cctactatgg taacctttac tatgctatgg actactgggg tcaaggaacc      780

tcagtcaccg tctcctcagt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgctgtgcg cacgcccacg ccgcagcccc      960

gcccaagaag atggcaaagt ctacatcaac atgccaggca ggggccttag agtgaagttc     1020

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc     1080

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1140

atggggggaa agccgcagag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1200

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1260

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1320

cttcacatgc aggccctgcc ccctcgcgcc agggccaaaa ggtctggctc cggtgagggc     1380

agaggaagtc ttctaacatg cggtgacgtg gaggagaatc ccggccctat gccacctcct     1440

cgcctcctct tcttcctcct cttcctcacc cccatggaag tcaggcccga ggaacctcta     1500

gtggtgaagg tggaagaggg agataacgct gtgctgcagt gcctcaaggg gacctcagat     1560

ggccccactc agcagctgac ctggtctcgg gagtccccgc ttaaaccctt cttaaaactc     1620

agcctggggc tgccaggcct gggaatccac atgaggcccc tggccatctg gcttttcatc     1680

ttcaacgtct ctcaacagat ggggggcttc tacctgtgcc agccggggcc cccctctgag     1740

aaggcctggc agcctggctg gacagtcaat gtggagggca gcggggagct gttccggtgg     1800

aatgtttcgg acctaggtgg cctgggctgt ggcctgaaga acaggtcctc agagggcccc     1860

agctcccctt ccgggaagct catgagcccc aagctgtatg tgtgggccaa agaccgccct     1920

gagatctggg agggagagcc tccgtgtctc ccaccgaggg acagcctgaa ccagagcctc     1980

agccaggacc tcaccatggc ccctggctcc acactctggc tgtcctgtgg ggtaccccct     2040

gactctgtgt ccaggggccc cctctcctgg acccatgtgc accccaaggg gcctaagtca     2100

ttgctgagcc tagagctgaa ggacgatcgc ccggccagag atatgtgggt aatggagacg     2160

ggtctgttgt tgccccgggc cacagctcaa gacgctggaa agtattattg tcaccgtggc     2220

aacctgacca tgtcattcca cctggagatc actgctcggc cagtactatg gcactggctg     2280

ctgaggactg gtggctggaa ggtctcagct gtgactttgg cttatctgat cttctgcctg     2340

tgttcccttg tgggcattct tcatcttcaa agagccctgg tcctgaggag gaaaagaaag     2400

cgaatgactt aa                                                         2412


<210>  296
<211>  2277
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3zICS-CD28CS-TWEAK-T2A-trCD19

<400>  296
cttagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag       60

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt      120

ggccgggacc ctgagatggg gggaaagccg cagagaagga agaaccctca ggaaggcctg      180

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc      240

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag      300

gacacctacg acgcccttca catgcaggcc ctgccccctc gcaggagtaa gaggagcagg      360

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat      420

taccagccct atgccccacc acgcgacttc gcagcctatc gctccgccgc ccgtcggagc      480

cagaggcgga gggggcgccg gggggagccg ggcaccgccc tgctggtccc gctcgcgctg      540

ggcctgggcc tggcgctggc ctgcctcggc ctcctgctgg ccgtggtcag tttggggagc      600

cgggcatcgc tgtccgccca ggagcctgcc caggaggagc tggtggcaga ggaggaccag      660

gacccgtcgg aactgaatcc ccagacagaa gaaagccagg atcctgcgcc tttcctgaac      720

cgactagttc ggcctcgcag aagtgcacct aaaggccgga aaacacgggc tcgaagagcg      780

atcgcagccc attatgaagt tcatccacga cctggacagg acggagcgca ggcaggtgtg      840

gacgggacag tgagtggctg ggaggaagcc agaatcaaca gctccagccc tctgcgctac      900

aaccgccaga tcggggagtt tatagtcacc cgggctgggc tctactacct gtactgtcag      960

gtgcactttg atgaggggaa ggctgtctac ctgaagctgg acttgctggt ggatggtgtg     1020

ctggccctgc gctgcctgga ggaattctca gccactgcgg ccagttccct cgggccccag     1080

ctccgcctct gccaggtgtc tgggctgttg gccctgcggc cagggtcctc cctgcggatc     1140

cgcaccctcc cctgggccca tctcaaggct gcccccttcc tcacctactt cggactcttc     1200

caggttcact gagccagggc caaaaggtct ggctccggtg agggcagagg aagtcttcta     1260

acatgcggtg acgtggagga gaatcccggc cctatgccac ctcctcgcct cctcttcttc     1320

ctcctcttcc tcacccccat ggaagtcagg cccgaggaac ctctagtggt gaaggtggaa     1380

gagggagata acgctgtgct gcagtgcctc aaggggacct cagatggccc cactcagcag     1440

ctgacctggt ctcgggagtc cccgcttaaa cccttcttaa aactcagcct ggggctgcca     1500

ggcctgggaa tccacatgag gcccctggcc atctggcttt tcatcttcaa cgtctctcaa     1560

cagatggggg gcttctacct gtgccagccg gggcccccct ctgagaaggc ctggcagcct     1620

ggctggacag tcaatgtgga gggcagcggg gagctgttcc ggtggaatgt ttcggaccta     1680

ggtggcctgg gctgtggcct gaagaacagg tcctcagagg gccccagctc cccttccggg     1740

aagctcatga gccccaagct gtatgtgtgg gccaaagacc gccctgagat ctgggaggga     1800

gagcctccgt gtctcccacc gagggacagc ctgaaccaga gcctcagcca ggacctcacc     1860

atggcccctg gctccacact ctggctgtcc tgtggggtac cccctgactc tgtgtccagg     1920

ggccccctct cctggaccca tgtgcacccc aaggggccta agtcattgct gagcctagag     1980

ctgaaggacg atcgcccggc cagagatatg tgggtaatgg agacgggtct gttgttgccc     2040

cgggccacag ctcaagacgc tggaaagtat tattgtcacc gtggcaacct gaccatgtca     2100

ttccacctgg agatcactgc tcggccagta ctatggcact ggctgctgag gactggtggc     2160

tggaaggtct cagctgtgac tttggcttat ctgatcttct gcctgtgttc ccttgtgggc     2220

attcttcatc ttcaaagagc cctggtcctg aggaggaaaa gaaagcgaat gacttaa        2277


<210>  297
<211>  2280
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3zICS-41BBCS -TWEAK-T2A-trCD19

<400>  297
cttagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag       60

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt      120

ggccgggacc ctgagatggg gggaaagccg cagagaagga agaaccctca ggaaggcctg      180

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc      240

gagcaaacgg ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt      300

acaaactact caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg      360

atgtgaactg gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc      420

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcgc cgcccgtcgg      480

agccagaggc ggagggggcg ccggggggag ccgggcaccg ccctgctggt cccgctcgcg      540

ctgggcctgg gcctggcgct ggcctgcctc ggcctcctgc tggccgtggt cagtttgggg      600

agccgggcat cgctgtccgc ccaggagcct gcccaggagg agctggtggc agaggaggac      660

caggacccgt cggaactgaa tccccagaca gaagaaagcc aggatcctgc gcctttcctg      720

aaccgactag ttcggcctcg cagaagtgca cctaaaggcc ggaaaacacg ggctcgaaga      780

gcgatcgcag cccattatga agttcatcca cgacctggac aggacggagc gcaggcaggt      840

gtggacggga cagtgagtgg ctgggaggaa gccagaatca acagctccag ccctctgcgc      900

tacaaccgcc agatcgggga gtttatagtc acccgggctg ggctctacta cctgtactgt      960

caggtgcact ttgatgaggg gaaggctgtc tacctgaagc tggacttgct ggtggatggt     1020

gtgctggccc tgcgctgcct ggaggaattc tcagccactg cggccagttc cctcgggccc     1080

cagctccgcc tctgccaggt gtctgggctg ttggccctgc ggccagggtc ctccctgcgg     1140

atccgcaccc tcccctgggc ccatctcaag gctgccccct tcctcaccta cttcggactc     1200

ttccaggttc actgagccag ggccaaaagg tctggctccg gtgagggcag aggaagtctt     1260

ctaacatgcg gtgacgtgga ggagaatccc ggccctatgc cacctcctcg cctcctcttc     1320

ttcctcctct tcctcacccc catggaagtc aggcccgagg aacctctagt ggtgaaggtg     1380

gaagagggag ataacgctgt gctgcagtgc ctcaagggga cctcagatgg ccccactcag     1440

cagctgacct ggtctcggga gtccccgctt aaacccttct taaaactcag cctggggctg     1500

ccaggcctgg gaatccacat gaggcccctg gccatctggc ttttcatctt caacgtctct     1560

caacagatgg ggggcttcta cctgtgccag ccggggcccc cctctgagaa ggcctggcag     1620

cctggctgga cagtcaatgt ggagggcagc ggggagctgt tccggtggaa tgtttcggac     1680

ctaggtggcc tgggctgtgg cctgaagaac aggtcctcag agggccccag ctccccttcc     1740

gggaagctca tgagccccaa gctgtatgtg tgggccaaag accgccctga gatctgggag     1800

ggagagcctc cgtgtctccc accgagggac agcctgaacc agagcctcag ccaggacctc     1860

accatggccc ctggctccac actctggctg tcctgtgggg taccccctga ctctgtgtcc     1920

aggggccccc tctcctggac ccatgtgcac cccaaggggc ctaagtcatt gctgagccta     1980

gagctgaagg acgatcgccc ggccagagat atgtgggtaa tggagacggg tctgttgttg     2040

ccccgggcca cagctcaaga cgctggaaag tattattgtc accgtggcaa cctgaccatg     2100

tcattccacc tggagatcac tgctcggcca gtactatggc actggctgct gaggactggt     2160

ggctggaagg tctcagctgt gactttggct tatctgatct tctgcctgtg ttcccttgtg     2220

ggcattcttc atcttcaaag agccctggtc ctgaggagga aaagaaagcg aatgacttaa     2280


<210>  298
<211>  2226
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3zICS-DAP10CS-TWEAK-T2A-trCD19

<400>  298
cttagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag       60

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt      120

ggccgggacc ctgagatggg gggaaagccg cagagaagga agaaccctca ggaaggcctg      180

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc      240

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag      300

gacacctacg acgcccttca catgcaggcc ctgccccctc gcctgtgcgc acgcccacgc      360

cgcagccccg cccaagaaga tggcaaagtc tacatcaaca tgccaggcag gggcgccgcc      420

cgtcggagcc agaggcggag ggggcgccgg ggggagccgg gcaccgccct gctggtcccg      480

ctcgcgctgg gcctgggcct ggcgctggcc tgcctcggcc tcctgctggc cgtggtcagt      540

ttggggagcc gggcatcgct gtccgcccag gagcctgccc aggaggagct ggtggcagag      600

gaggaccagg acccgtcgga actgaatccc cagacagaag aaagccagga tcctgcgcct      660

ttcctgaacc gactagttcg gcctcgcaga agtgcaccta aaggccggaa aacacgggct      720

cgaagagcga tcgcagccca ttatgaagtt catccacgac ctggacagga cggagcgcag      780

gcaggtgtgg acgggacagt gagtggctgg gaggaagcca gaatcaacag ctccagccct      840

ctgcgctaca accgccagat cggggagttt atagtcaccc gggctgggct ctactacctg      900

tactgtcagg tgcactttga tgaggggaag gctgtctacc tgaagctgga cttgctggtg      960

gatggtgtgc tggccctgcg ctgcctggag gaattctcag ccactgcggc cagttccctc     1020

gggccccagc tccgcctctg ccaggtgtct gggctgttgg ccctgcggcc agggtcctcc     1080

ctgcggatcc gcaccctccc ctgggcccat ctcaaggctg cccccttcct cacctacttc     1140

ggactcttcc aggttcactg agccagggcc aaaaggtctg gctccggtga gggcagagga     1200

agtcttctaa catgcggtga cgtggaggag aatcccggcc ctatgccacc tcctcgcctc     1260

ctcttcttcc tcctcttcct cacccccatg gaagtcaggc ccgaggaacc tctagtggtg     1320

aaggtggaag agggagataa cgctgtgctg cagtgcctca aggggacctc agatggcccc     1380

actcagcagc tgacctggtc tcgggagtcc ccgcttaaac ccttcttaaa actcagcctg     1440

gggctgccag gcctgggaat ccacatgagg cccctggcca tctggctttt catcttcaac     1500

gtctctcaac agatgggggg cttctacctg tgccagccgg ggcccccctc tgagaaggcc     1560

tggcagcctg gctggacagt caatgtggag ggcagcgggg agctgttccg gtggaatgtt     1620

tcggacctag gtggcctggg ctgtggcctg aagaacaggt cctcagaggg ccccagctcc     1680

ccttccggga agctcatgag ccccaagctg tatgtgtggg ccaaagaccg ccctgagatc     1740

tgggagggag agcctccgtg tctcccaccg agggacagcc tgaaccagag cctcagccag     1800

gacctcacca tggcccctgg ctccacactc tggctgtcct gtggggtacc ccctgactct     1860

gtgtccaggg gccccctctc ctggacccat gtgcacccca aggggcctaa gtcattgctg     1920

agcctagagc tgaaggacga tcgcccggcc agagatatgt gggtaatgga gacgggtctg     1980

ttgttgcccc gggccacagc tcaagacgct ggaaagtatt attgtcaccg tggcaacctg     2040

accatgtcat tccacctgga gatcactgct cggccagtac tatggcactg gctgctgagg     2100

actggtggct ggaaggtctc agctgtgact ttggcttatc tgatcttctg cctgtgttcc     2160

cttgtgggca ttcttcatct tcaaagagcc ctggtcctga ggaggaaaag aaagcgaatg     2220

acttaa                                                                2226


<210> 299

<400> 299
000

<210> 300

<400> 300
000


<210>  301
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human glutaredoxin 1 (hGRX1)

<400>  301

Met Ala Gln Glu Phe Val Asn Cys Lys Ile Gln Pro Gly Lys Val Val 
1               5                   10                  15      


Val Phe Ile Lys Pro Thr Cys Pro Tyr Cys Arg Arg Ala Gln Glu Ile 
            20                  25                  30          


Leu Ser Gln Leu Pro Ile Lys Gln Gly Leu Leu Glu Phe Val Asp Ile 
        35                  40                  45              


Thr Ala Thr Asn His Thr Asn Glu Ile Gln Asp Tyr Leu Gln Gln Leu 
    50                  55                  60                  


Thr Gly Ala Arg Thr Val Pro Arg Val Phe Ile Gly Lys Asp Cys Ile 
65                  70                  75                  80  


Gly Gly Cys Ser Asp Leu Val Ser Leu Gln Gln Ser Gly Glu Leu Leu 
                85                  90                  95      


Thr Arg Leu Lys Gln Ile Gly Ala Leu Gln 
            100                 105     


<210>  302
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human glutaredoxin 2 (hGRX2)

<400>  302

Met Glu Ser Asn Thr Ser Ser Ser Leu Glu Asn Leu Ala Thr Ala Pro 
1               5                   10                  15      


Val Asn Gln Ile Gln Glu Thr Ile Ser Asp Asn Cys Val Val Ile Phe 
            20                  25                  30          


Ser Lys Thr Ser Cys Ser Tyr Cys Thr Met Ala Lys Lys Leu Phe His 
        35                  40                  45              


Asp Met Asn Val Asn Tyr Lys Val Val Glu Leu Asp Leu Leu Glu Tyr 
    50                  55                  60                  


Gly Asn Gln Phe Gln Asp Ala Leu Tyr Lys Met Thr Gly Glu Arg Thr 
65                  70                  75                  80  


Val Pro Arg Ile Phe Val Asn Gly Thr Phe Ile Gly Gly Ala Thr Asp 
                85                  90                  95      


Thr His Arg Leu His Lys Glu Gly Lys Leu Leu Pro Leu Val His Gln 
            100                 105                 110         


Cys Tyr Leu Lys Lys Ser Lys Arg Lys Glu Phe Gln 
        115                 120                 


<210>  303
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human glutaredoxin 3 (hGRX3)

<400>  303

Met Ala Ala Gly Ala Ala Glu Ala Ala Val Ala Ala Val Glu Glu Val 
1               5                   10                  15      


Gly Ser Ala Gly Gln Phe Glu Glu Leu Leu Arg Leu Lys Ala Lys Ser 
            20                  25                  30          


Leu Leu Val Val His Phe Trp Ala Pro Trp Ala Pro Gln Cys Ala Gln 
        35                  40                  45              


Met Asn Glu Val Met Ala Glu Leu Ala Lys Glu Leu Pro Gln Val Ser 
    50                  55                  60                  


Phe Val Lys Leu Glu Ala Glu Gly Val Pro Glu Val Ser Glu Lys Tyr 
65                  70                  75                  80  


Glu Ile Ser Ser Val Pro Thr Phe Leu Phe Phe Lys Asn Ser Gln Lys 
                85                  90                  95      


Ile Asp Arg Leu Asp Gly Ala His Ala Pro Glu Leu Thr Lys Lys Val 
            100                 105                 110         


Gln Arg His Ala Ser Ser Gly Ser Phe Leu Pro Ser Ala Asn Glu His 
        115                 120                 125             


Leu Lys Glu Asp Leu Asn Leu Arg Leu Lys Lys Leu Thr His Ala Ala 
    130                 135                 140                 


Pro Cys Met Leu Phe Met Lys Gly Thr Pro Gln Glu Pro Arg Cys Gly 
145                 150                 155                 160 


Phe Ser Lys Gln Met Val Glu Ile Leu His Lys His Asn Ile Gln Phe 
                165                 170                 175     


Ser Ser Phe Asp Ile Phe Ser Asp Glu Glu Val Arg Gln Gly Leu Lys 
            180                 185                 190         


Ala Tyr Ser Ser Trp Pro Thr Tyr Pro Gln Leu Tyr Val Ser Gly Glu 
        195                 200                 205             


Leu Ile Gly Gly Leu Asp Ile Ile Lys Glu Leu Glu Ala Ser Glu Glu 
    210                 215                 220                 


Leu Asp Thr Ile Cys Pro Lys Ala Pro Lys Leu Glu Glu Arg Leu Lys 
225                 230                 235                 240 


Val Leu Thr Asn Lys Ala Ser Val Met Leu Phe Met Lys Gly Asn Lys 
                245                 250                 255     


Gln Glu Ala Lys Cys Gly Phe Ser Lys Gln Ile Leu Glu Ile Leu Asn 
            260                 265                 270         


Ser Thr Gly Val Glu Tyr Glu Thr Phe Asp Ile Leu Glu Asp Glu Glu 
        275                 280                 285             


Val Arg Gln Gly Leu Lys Ala Tyr Ser Asn Trp Pro Thr Tyr Pro Gln 
    290                 295                 300                 


Leu Tyr Val Lys Gly Glu Leu Val Gly Gly Leu Asp Ile Val Lys Glu 
305                 310                 315                 320 


Leu Lys Glu Asn Gly Glu Leu Leu Pro Ile Leu Arg Gly Glu Asn 
                325                 330                 335 


<210> 304

<400> 304
000


<210>  305
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human glutaredoxin 5 (hGRX5)

<400>  305

Met Ser Gly Ser Leu Gly Arg Ala Ala Ala Ala Leu Leu Arg Trp Gly 
1               5                   10                  15      


Arg Gly Ala Gly Gly Gly Gly Leu Trp Gly Pro Gly Val Arg Ala Ala 
            20                  25                  30          


Gly Ser Gly Ala Gly Gly Gly Gly Ser Ala Glu Gln Leu Asp Ala Leu 
        35                  40                  45              


Val Lys Lys Asp Lys Val Val Val Phe Leu Lys Gly Thr Pro Glu Gln 
    50                  55                  60                  


Pro Gln Cys Gly Phe Ser Asn Ala Val Val Gln Ile Leu Arg Leu His 
65                  70                  75                  80  


Gly Val Arg Asp Tyr Ala Ala Tyr Asn Val Leu Asp Asp Pro Glu Leu 
                85                  90                  95      


Arg Gln Gly Ile Lys Asp Tyr Ser Asn Trp Pro Thr Ile Pro Gln Val 
            100                 105                 110         


Tyr Leu Asn Gly Glu Phe Val Gly Gly Cys Asp Ile Leu Leu Gln Met 
        115                 120                 125             


His Gln Asn Gly Asp Leu Val Glu Glu Leu Lys Lys Leu Gly Ile His 
    130                 135                 140                 


Ser Thr Leu Leu Asp Glu Lys Lys Asp Gln Asp Ser Lys 
145                 150                 155         



<210> 306

<400> 306
000

<210> 307

<400> 307
000

<210> 308

<400> 308
000

<210> 309

<400> 309
000

<210> 310

<400> 310
000


<210>  311
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse glutaredoxin 1 (mGRX1)

<400>  311

Met Ala Gln Glu Phe Val Asn Cys Lys Ile Gln Ser Gly Lys Val Val 
1               5                   10                  15      


Val Phe Ile Lys Pro Thr Cys Pro Tyr Cys Arg Lys Thr Gln Glu Ile 
            20                  25                  30          


Leu Ser Gln Leu Pro Phe Lys Gln Gly Leu Leu Glu Phe Val Asp Ile 
        35                  40                  45              


Thr Ala Thr Asn Asn Thr Ser Ala Ile Gln Asp Tyr Leu Gln Gln Leu 
    50                  55                  60                  


Thr Gly Ala Arg Thr Val Pro Arg Val Phe Ile Gly Lys Asp Cys Ile 
65                  70                  75                  80  


Gly Gly Cys Ser Asp Leu Ile Ser Met Gln Gln Thr Gly Glu Leu Met 
                85                  90                  95      


Thr Arg Leu Lys Gln Ile Gly Ala Leu Gln Leu 
            100                 105         


<210> 312

<400> 312
000

<210> 313

<400> 313
000

<210> 314

<400> 314
000

<210> 315

<400> 315
000

<210> 316

<400> 316
000

<210> 317

<400> 317
000

<210> 318

<400> 318
000

<210> 319

<400> 319
000

<210> 320

<400> 320
000

<210> 321

<400> 321
000


<210>  322
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Functional human GRX1 variant 2 (hGRX1v2) -EFVA- mutant

<400>  322

Met Ala Gln Glu Phe Val Asn Cys Lys Ile Gln Pro Gly Lys Val Val 
1               5                   10                  15      


Val Phe Ile Lys Pro Thr Cys Pro Tyr Cys Arg Arg Ala Gln Glu Ile 
            20                  25                  30          


Leu Ser Gln Leu Pro Ile Lys Gln Gly Leu Leu Glu Phe Val Ala Ile 
        35                  40                  45              


Thr Ala Thr Asn His Thr Asn Glu Ile Gln Asp Tyr Leu Gln Gln Leu 
    50                  55                  60                  


Thr Gly Ala Arg Thr Val Pro Arg Val Phe Ile Gly Lys Asp Cys Ile 
65                  70                  75                  80  


Gly Gly Cys Ser Asp Leu Val Ser Leu Gln Gln Ser Gly Glu Leu Leu 
                85                  90                  95      


Thr Arg Leu Lys Gln Ile Gly Ala Leu Gln 
            100                 105     


<210> 323

<400> 323
000

<210> 324

<400> 324
000

<210> 325

<400> 325
000

<210> 326

<400> 326
000

<210> 327

<400> 327
000

<210> 328

<400> 328
000

<210> 329

<400> 329
000

<210> 330

<400> 330
000

<210> 331

<400> 331
000


<210>  332
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Functional human GRX1 variant 12 (hGRX1v2) -C7S C79S C83S- mutant

<400>  332

Met Ala Gln Glu Phe Val Asn Ser Lys Ile Gln Pro Gly Lys Val Val 
1               5                   10                  15      


Val Phe Ile Lys Pro Thr Cys Pro Tyr Cys Arg Arg Ala Gln Glu Ile 
            20                  25                  30          


Leu Ser Gln Leu Pro Ile Lys Gln Gly Leu Leu Glu Phe Val Asp Ile 
        35                  40                  45              


Thr Ala Thr Asn His Thr Asn Glu Ile Gln Asp Tyr Leu Gln Gln Leu 
    50                  55                  60                  


Thr Gly Ala Arg Thr Val Pro Arg Val Phe Ile Gly Lys Asp Ser Ile 
65                  70                  75                  80  


Gly Gly Ser Ser Asp Leu Val Ser Leu Gln Gln Ser Gly Glu Leu Leu 
                85                  90                  95      


Thr Arg Leu Lys Gln Ile Gly Ala Leu Gln 
            100                 105     


<210> 333

<400> 333
000

<210> 334

<400> 334
000

<210> 335

<400> 335
000

<210> 336

<400> 336
000

<210> 337

<400> 337
000

<210> 338

<400> 338
000

<210> 339

<400> 339
000

<210> 340

<400> 340
000


<210>  341
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human glutathione S-transferase P(hGSTP)

<400>  341

Met Pro Pro Tyr Thr Val Val Tyr Phe Pro Val Arg Gly Arg Cys Ala 
1               5                   10                  15      


Ala Leu Arg Met Leu Leu Ala Asp Gln Gly Gln Ser Trp Lys Glu Glu 
            20                  25                  30          


Val Val Thr Val Glu Thr Trp Gln Glu Gly Ser Leu Lys Ala Ser Cys 
        35                  40                  45              


Leu Tyr Gly Gln Leu Pro Lys Phe Gln Asp Gly Asp Leu Thr Leu Tyr 
    50                  55                  60                  


Gln Ser Asn Thr Ile Leu Arg His Leu Gly Arg Thr Leu Gly Leu Tyr 
65                  70                  75                  80  


Gly Lys Asp Gln Gln Glu Ala Ala Leu Val Asp Met Val Asn Asp Gly 
                85                  90                  95      


Val Glu Asp Leu Arg Cys Lys Tyr Ile Ser Leu Ile Tyr Thr Asn Tyr 
            100                 105                 110         


Glu Ala Gly Lys Asp Asp Tyr Val Lys Ala Leu Pro Gly Gln Leu Lys 
        115                 120                 125             


Pro Phe Glu Thr Leu Leu Ser Gln Asn Gln Gly Gly Lys Thr Phe Ile 
    130                 135                 140                 


Val Gly Asp Gln Ile Ser Phe Ala Asp Tyr Asn Leu Leu Asp Leu Leu 
145                 150                 155                 160 


Leu Ile His Glu Val Leu Ala Pro Gly Cys Leu Asp Ala Phe Pro Leu 
                165                 170                 175     


Leu Ser Ala Tyr Val Gly Arg Leu Ser Ala Arg Pro Lys Leu Lys Ala 
            180                 185                 190         


Phe Leu Ala Ser Pro Glu Tyr Val Asn Leu Pro Ile Asn Gly Asn Gly 
        195                 200                 205             


Lys Gln 
    210 


<210> 342

<400> 342
000

<210> 343

<400> 343
000

<210> 344

<400> 344
000

<210> 345

<400> 345
000

<210> 346

<400> 346
000

<210> 347

<400> 347
000

<210> 348

<400> 348
000

<210> 349

<400> 349
000

<210> 350

<400> 350
000


<210>  351
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse glutathione S-transferase P (mGSTP)

<400>  351

Met Pro Pro Tyr Thr Ile Val Tyr Phe Pro Val Arg Gly Arg Cys Glu 
1               5                   10                  15      


Ala Met Arg Met Leu Leu Ala Asp Gln Gly Gln Ser Trp Lys Glu Glu 
            20                  25                  30          


Val Val Thr Ile Asp Thr Trp Met Gln Gly Leu Leu Lys Pro Thr Cys 
        35                  40                  45              


Leu Tyr Gly Gln Leu Pro Lys Phe Glu Asp Gly Asp Leu Thr Leu Tyr 
    50                  55                  60                  


Gln Ser Asn Ala Ile Leu Arg His Leu Gly Arg Ser Leu Gly Leu Tyr 
65                  70                  75                  80  


Gly Lys Asn Gln Arg Glu Ala Ala Gln Met Asp Met Val Asn Asp Gly 
                85                  90                  95      


Val Glu Asp Leu Arg Gly Lys Tyr Val Thr Leu Ile Tyr Thr Asn Tyr 
            100                 105                 110         


Glu Asn Gly Lys Asn Asp Tyr Val Lys Ala Leu Pro Gly His Leu Lys 
        115                 120                 125             


Pro Phe Glu Thr Leu Leu Ser Gln Asn Gln Gly Gly Lys Ala Phe Ile 
    130                 135                 140                 


Val Gly Asp Gln Ile Ser Phe Ala Asp Tyr Asn Leu Leu Asp Leu Leu 
145                 150                 155                 160 


Leu Ile His Gln Val Leu Ala Pro Gly Cys Leu Asp Asn Phe Pro Leu 
                165                 170                 175     


Leu Ser Ala Tyr Val Ala Arg Leu Ser Ala Arg Pro Lys Ile Lys Ala 
            180                 185                 190         


Phe Leu Ser Ser Pro Glu His Val Asn Arg Pro Ile Asn Gly Asn Gly 
        195                 200                 205             


Lys Gln 
    210 


<210> 352

<400> 352
000

<210> 353

<400> 353
000

<210> 354

<400> 354
000

<210> 355

<400> 355
000

<210> 356

<400> 356
000

<210> 357

<400> 357
000

<210> 358

<400> 358
000

<210> 359

<400> 359
000

<210> 360

<400> 360
000

<210> 361

<400> 361
000

<210> 362

<400> 362
000

<210> 363

<400> 363
000

<210> 364

<400> 364
000

<210> 365

<400> 365
000

<210> 366

<400> 366
000

<210> 367

<400> 367
000

<210> 368

<400> 368
000

<210> 369

<400> 369
000

<210> 370

<400> 370
000

<210> 371

<400> 371
000

<210> 372

<400> 372
000

<210> 373

<400> 373
000

<210> 374

<400> 374
000

<210> 375

<400> 375
000

<210> 376

<400> 376
000

<210> 377

<400> 377
000

<210> 378

<400> 378
000

<210> 379

<400> 379
000

<210> 380

<400> 380
000

<210> 381

<400> 381
000

<210> 382

<400> 382
000

<210> 383

<400> 383
000

<210> 384

<400> 384
000

<210> 385

<400> 385
000

<210> 386

<400> 386
000

<210> 387

<400> 387
000

<210> 388

<400> 388
000

<210> 389

<400> 389
000

<210> 390

<400> 390
000

<210> 391

<400> 391
000

<210> 392

<400> 392
000

<210> 393

<400> 393
000

<210> 394

<400> 394
000

<210> 395

<400> 395
000

<210> 396

<400> 396
000

<210> 397

<400> 397
000

<210> 398

<400> 398
000

<210> 399

<400> 399
000

<210> 400

<400> 400
000


<210>  401
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human glutaredoxin 1 (hGRX1)

<400>  401
atggctcaag agtttgtgaa ctgcaaaatc cagcctggga aggtggttgt gttcatcaag       60

cccacctgcc cgtactgcag gagggcccaa gagatcctca gtcaattgcc catcaaacaa      120

gggcttctgg aatttgtcga tatcacagcc accaaccaca ctaacgagat tcaagattat      180

ttgcaacagc tcacgggagc aagaacggtg cctcgagtct ttattggtaa agattgtata      240

ggcggatgca gtgatctagt ctctttgcaa cagagtgggg aactgctgac gcggctaaag      300

cagattggag ctctgcagta g                                                321


<210>  402
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human glutaredoxin 2 (hGRX2)

<400>  402
atggagagca atacatcatc atctttggag aatttagcga cggcgcctgt gaaccagatc       60

caagaaacaa tttctgataa ttgtgtggtg attttctcaa aaacatcctg ttcttactgt      120

acaatggcaa aaaagctttt ccatgacatg aatgttaact ataaagtggt ggaactggac      180

ctgcttgaat atggaaacca gttccaagat gctctttaca aaatgactgg tgaaagaact      240

gttccaagaa tatttgtcaa tggtactttt attggaggtg caactgacac tcataggctt      300

cacaaagaag gaaaattgct cccactagtt catcagtgtt atttaaaaaa aagtaagagg      360

aaagaatttc agtga                                                       375


<210>  403
<211>  960
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human glutaredoxin 3 (hGRX3)

<400>  403
ggctcagccg ggcagtttga ggagctgctg cgcctcaaag ccaagtccct ccttgtggtc       60

catttctggg caccatgggc tccacagtgt gcacagatga acgaagttat ggcagagtta      120

gctaaagaac tccctcaagt ttcatttgtg aagttggaag ctgaaggtgt tcctgaagta      180

tctgaaaaat atgaaattag ctctgttccc acttttctgt ttttcaagaa ttctcagaaa      240

atcgaccgat tagatggtgc acatgcccca gagttgacca aaaaagttca gcgacatgca      300

tctagtggct ccttcctacc cagcgctaat gaacatctta aagaagatct caaccttcgc      360

ttgaagaaat tgactcatgc tgccccctgc atgctgttta tgaaaggaac tcctcaagaa      420

ccacgctgtg gtttcagcaa gcagatggtg gaaattcttc acaaacataa tattcagttt      480

agcagttttg atatcttctc agatgaagag gttcgacagg gactcaaagc ctattccagt      540

tggcctacct atcctcagct ctatgtttct ggagagctca taggaggact tgatataatt      600

aaggagctag aagcatctga agaactagat acaatttgtc ccaaagctcc caaattagag      660

gaaaggctca aagtgctgac aaataaagct tctgtgatgc tctttatgaa aggaaacaaa      720

caggaagcaa aatgtggatt cagcaaacaa attctggaaa tactaaatag tactggtgtt      780

gaatatgaaa cattcgatat attggaggat gaagaagttc ggcaaggatt aaaagcttac      840

tcaaattggc caacataccc tcagctgtat gtgaaagggg agctggtggg aggattggat      900

attgtgaagg aactgaaaga aaatggtgaa ttgctgccta tactgagagg agaaaattaa      960


<210> 404

<400> 404
000


<210>  405
<211>  474
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human glutaredoxin 5 (hGRX5)

<400>  405
atgagcgggt ccctcggccg agctgcggcg gctctgctcc gctgggggcg cggcgcgggc       60

ggcggtggcc tttggggtcc gggcgtgcgg gcggcgggct cgggcgcggg cggcggcggc      120

tcggcggagc agttggacgc gctggtgaag aaggacaagg tggtggtctt cctcaagggg      180

acgccggagc agccccagtg cggcttcagc aacgccgtgg tgcagatcct gcggctgcac      240

ggcgtccgcg attacgcggc ctacaacgtg ctggacgacc cggagctccg acaaggcatt      300

aaagactatt ccaactggcc caccatcccg caagtgtacc tcaatggcga gtttgtaggg      360

ggctgtgaca ttcttctgca gatgcaccag aatggggact tggtggaaga actgaaaaag      420

ctggggatcc actccaccct tttagatgaa aagaaagacc aagactccaa gtga            474



<210> 406

<400> 406
000

<210> 407

<400> 407
000

<210> 408

<400> 408
000

<210> 409

<400> 409
000

<210> 410

<400> 410
000


<210>  411
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse glutaredoxin 1 (mGRX1)

<400>  411
atggctcagg agtttgtgaa ctgcaagatc cagtctggga aggtggtcgt gttcatcaag       60

cccacctgcc cctactgcag aaagacccaa gaaatcctca gtcaactgcc tttcaaacaa      120

ggtcttctgg agtttgtgga catcacagcc actaacaaca ccagtgcgat tcaagattat      180

ttacaacagc tcaccggagc gagaacagtt cctcgggtct tcataggtaa agactgcata      240

ggcggatgca gtgatctaat ctccatgcaa cagactgggg agctgatgac tcggctgaag      300

cagattggag ctctgcagtt ataa                                             324


<210> 412

<400> 412
000

<210> 413

<400> 413
000

<210> 414

<400> 414
000

<210> 415

<400> 415
000

<210> 416

<400> 416
000

<210> 417

<400> 417
000

<210> 418

<400> 418
000

<210> 419

<400> 419
000

<210> 420

<400> 420
000

<210> 421

<400> 421
000


<210>  422
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Functional human GRX1 variant 2 (hGRX1v2) -EFVA- mutant

<400>  422
atggctcaag agtttgtgaa ctgcaaaatc cagcctggga aggtggttgt gttcatcaag       60

cccacctgcc cgtactgcag gagggcccaa gagatcctca gtcaattgcc catcaaacaa      120

gggcttctgg aatttgtcgc tatcacagcc accaaccaca ctaacgagat tcaagattat      180

ttgcaacagc tcacgggagc aagaacggtg cctcgagtct ttattggtaa agattgtata      240

ggcggatgca gtgatctagt ctctttgcaa cagagtgggg aactgctgac gcggctaaag      300

cagattggag ctctgcagta g                                                321


<210> 423

<400> 423
000

<210> 424

<400> 424
000

<210> 425

<400> 425
000

<210> 426

<400> 426
000

<210> 427

<400> 427
000

<210> 428

<400> 428
000

<210> 429

<400> 429
000

<210> 430

<400> 430
000

<210> 431

<400> 431
000


<210>  432
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Functional human GRX1 variant 12 (hGRX1v2) -C7S C79S C83S- mutant

<400>  432
atggctcaag agtttgtgaa cagcaaaatc cagcctggga aggtggttgt gttcatcaag       60

cccacctgcc cgtactgcag gagggcccaa gagatcctca gtcaattgcc catcaaacaa      120

gggcttctgg aatttgtcga tatcacagcc accaaccaca ctaacgagat tcaagattat      180

ttgcaacagc tcacgggagc aagaacggtg cctcgagtct ttattggtaa agattctata      240

ggcggatcca gtgatctagt ctctttgcaa cagagtgggg aactgctgac gcggctaaag      300

cagattggag ctctgcagta g                                                321



<210> 433

<400> 433
000

<210> 434

<400> 434
000

<210> 435

<400> 435
000

<210> 436

<400> 436
000

<210> 437

<400> 437
000

<210> 438

<400> 438
000

<210> 439

<400> 439
000

<210> 440

<400> 440
000



<210>  441
<211>  633
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human glutathione S-transferase P(hGSTP)

<400>  441
atgccgccct acaccgtggt ctatttccca gttcgaggcc gctgcgcggc cctgcgcatg       60

ctgctggcag atcagggcca gagctggaag gaggaggtgg tgaccgtgga gacgtggcag      120

gagggctcac tcaaagcctc ctgcctatac gggcagctcc ccaagttcca ggacggagac      180

ctcaccctgt accagtccaa taccatcctg cgtcacctgg gccgcaccct tgggctctat      240

gggaaggacc agcaggaggc agccctggtg gacatggtga atgacggcgt ggaggacctc      300

cgctgcaaat acgtctccct catctacacc aactatgagg cgggcaagga tgactatgtg      360

aaggcactgc ccgggcaact gaagcctttt gagaccctgc tgtcccagaa ccagggaggc      420

aagaccttca ttgtgggaga ccagatctcc ttcgctgact acaacctgct ggacttgctg      480

ctgatccatg aggtcctagc ccctggctgc ctggatgcgt tccccctgct ctcagcatat      540

gtggggcgcc tcagcgcccg gcccaagctc aaggccttcc tggcctcccc tgagtacgtg      600

aacctcccca tcaatggcaa cgggaaacag tga                                   633


<210> 442

<400> 442
000

<210> 443

<400> 443
000

<210> 444

<400> 444
000

<210> 445

<400> 445
000

<210> 446

<400> 446
000

<210> 447

<400> 447
000

<210> 448

<400> 448
000

<210> 449

<400> 449
000

<210> 450

<400> 450
000


<210>  451
<211>  633
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse glutathione S-transferase P (mGSTP)

<400>  451
atgccaccat acaccattgt ctacttccca gttcgagggc ggtgtgaggc catgcgaatg       60

ctgctggctg accagggcca gagctggaag gaggaggtgg ttaccataga tacctggatg      120

caaggcttgc tcaagcccac ttgtctgtat gggcagctcc ccaagtttga ggatggagac      180

ctcacccttt accaatctaa tgccatcttg agacaccttg gccgctcttt ggggctttat      240

gggaaaaacc agagggaggc cgcccagatg gatatggtga atgatggggt ggaggacctt      300

cgcggcaaat atgtcaccct catctacacc aactatgaga atggtaagaa tgactacgtg      360

aaggccctgc ctgggcatct gaagcctttt gagaccctgc tgtcccagaa ccagggaggc      420

aaagctttca tcgtgggtga ccagatctcc tttgccgatt acaacttgct ggacctgctg      480

ctgatccacc aagtcctggc ccctggctgc ctggacaact tccccctgct ctctgcctat      540

gtggctcgcc tcagtgcccg gcccaagatc aaggcctttc tgtcctcccc ggaacatgtg      600

aaccgtccca tcaatggcaa tggcaaacag tag                                   633


<210> 452

<400> 452
000

<210> 453

<400> 453
000

<210> 454

<400> 454
000

<210> 455

<400> 455
000

<210> 456

<400> 456
000

<210> 457

<400> 457
000

<210> 458

<400> 458
000

<210> 459

<400> 459
000

<210> 460

<400> 460
000

<210> 461

<400> 461
000

<210> 462

<400> 462
000

<210> 463

<400> 463
000

<210> 464

<400> 464
000

<210> 465

<400> 465
000

<210> 466

<400> 466
000

<210> 467

<400> 467
000

<210> 468

<400> 468
000

<210> 469

<400> 469
000

<210> 470

<400> 470
000

<210> 471

<400> 471
000

<210> 472

<400> 472
000

<210> 473

<400> 473
000

<210> 474

<400> 474
000

<210> 475

<400> 475
000

<210> 476

<400> 476
000

<210> 477

<400> 477
000

<210> 478

<400> 478
000

<210> 479

<400> 479
000

<210> 480

<400> 480
000

<210> 481

<400> 481
000

<210> 482

<400> 482
000

<210> 483

<400> 483
000

<210> 484

<400> 484
000

<210> 485

<400> 485
000

<210> 486

<400> 486
000

<210> 487

<400> 487
000

<210> 488

<400> 488
000

<210> 489

<400> 489
000

<210> 490

<400> 490
000

<210> 491

<400> 491
000

<210> 492

<400> 492
000

<210> 493

<400> 493
000

<210> 494

<400> 494
000

<210> 495

<400> 495
000

<210> 496

<400> 496
000

<210> 497

<400> 497
000

<210> 498

<400> 498
000

<210> 499

<400> 499
000

<210> 500

<400> 500
000

<210> 501

<400> 501
000

<210> 502

<400> 502
000

<210> 503

<400> 503
000

<210> 504

<400> 504
000

<210> 505

<400> 505
000

<210> 506

<400> 506
000

<210> 507

<400> 507
000

<210> 508

<400> 508
000

<210> 509

<400> 509
000

<210> 510

<400> 510
000

<210> 511

<400> 511
000

<210> 512

<400> 512
000

<210> 513

<400> 513
000

<210> 514

<400> 514
000

<210> 515

<400> 515
000

<210> 516

<400> 516
000

<210> 517

<400> 517
000

<210> 518

<400> 518
000

<210> 519

<400> 519
000

<210> 520

<400> 520
000

<210> 521

<400> 521
000

<210> 522

<400> 522
000

<210> 523

<400> 523
000

<210> 524

<400> 524
000

<210> 525

<400> 525
000

<210> 526

<400> 526
000

<210> 527

<400> 527
000

<210> 528

<400> 528
000

<210> 529

<400> 529
000

<210> 530

<400> 530
000

<210> 531

<400> 531
000

<210> 532

<400> 532
000

<210> 533

<400> 533
000

<210> 534

<400> 534
000

<210> 535

<400> 535
000

<210> 536

<400> 536
000

<210> 537

<400> 537
000

<210> 538

<400> 538
000

<210> 539

<400> 539
000

<210> 540

<400> 540
000

<210> 541

<400> 541
000

<210> 542

<400> 542
000

<210> 543

<400> 543
000

<210> 544

<400> 544
000

<210> 545

<400> 545
000

<210> 546

<400> 546
000

<210> 547

<400> 547
000

<210> 548

<400> 548
000

<210> 549

<400> 549
000

<210> 550

<400> 550
000

<210> 551

<400> 551
000

<210> 552

<400> 552
000

<210> 553

<400> 553
000

<210> 554

<400> 554
000

<210> 555

<400> 555
000

<210> 556

<400> 556
000

<210> 557

<400> 557
000

<210> 558

<400> 558
000

<210> 559

<400> 559
000

<210> 560

<400> 560
000

<210> 561

<400> 561
000

<210> 562

<400> 562
000

<210> 563

<400> 563
000

<210> 564

<400> 564
000

<210> 565

<400> 565
000

<210> 566

<400> 566
000

<210> 567

<400> 567
000

<210> 568

<400> 568
000

<210> 569

<400> 569
000

<210> 570

<400> 570
000

<210> 571

<400> 571
000

<210> 572

<400> 572
000

<210> 573

<400> 573
000

<210> 574

<400> 574
000

<210> 575

<400> 575
000

<210> 576

<400> 576
000

<210> 577

<400> 577
000


<210>  578
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm22.84-CD28H-CD28TM-CD28CS-CD3zICS

<400>  578

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
        35                  40                  45              


Ser Asn Tyr Val Asn Tyr Ala Met Gly Trp Phe Arg Gln Phe Pro Gly 
    50                  55                  60                  


Lys Glu Arg Glu Phe Val Ala Ser Ile Ser Trp Ser Ser Val Thr Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Ala His Leu Ala Gln Tyr Ser Asp Tyr 
        115                 120                 125             


Ala Tyr Arg Asp Pro His Gln Phe Gly Ala Trp Gly Gln Gly Thr Gln 
    130                 135                 140                 


Val Thr Val Ser Ser Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
145                 150                 155                 160 


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
                165                 170                 175     


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
            180                 185                 190         


Trp Val Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
        195                 200                 205             


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
    210                 215                 220                 


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Leu Arg Val Lys Phe Ser 
225                 230                 235                 240 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
                245                 250                 255     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            260                 265                 270         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
        275                 280                 285             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    290                 295                 300                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
305                 310                 315                 320 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                325                 330                 335     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345             


<210>  579
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm5.38-CD28H-CD28TM-CD28CS-CD3zICS

<400>  579

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asp 
        35                  40                  45              


Asp Asp Tyr Asp Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    50                  55                  60                  


Glu Gly Val Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Asp Phe Phe Arg Trp Asp Ser Gly Ser Tyr Tyr 
        115                 120                 125             


Val Arg Gly Cys Arg His Ala Thr Tyr Asp Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Gln Val Thr Val Ser Ser Val Lys Gly Lys His Leu Cys Pro Ser Pro 
145                 150                 155                 160 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
                165                 170                 175     


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
            180                 185                 190         


Phe Trp Val Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
        195                 200                 205             


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
    210                 215                 220                 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Leu Arg Val Lys Phe 
225                 230                 235                 240 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                245                 250                 255     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            260                 265                 270         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
        275                 280                 285             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    290                 295                 300                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
305                 310                 315                 320 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                325                 330                 335     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345                 


<210>  580
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VHVL-CD28H-CD28TM-CD28CS-CD3zICS

<400>  580

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg 
            20                  25                  30          


Pro Gly Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Gly Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
                165                 170                 175     


Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys 
        195                 200                 205             


Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His Pro Val Glu Glu Glu 
225                 230                 235                 240 


Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr 
                245                 250                 255     


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Ser Lys Arg Ser Arg Leu Leu His Ser 
305                 310                 315                 320 


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
                325                 330                 335     


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Leu 
            340                 345                 350         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        355                 360                 365             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    370                 375                 380                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
385                 390                 395                 400 


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                405                 410                 415     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            420                 425                 430         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        435                 440                 445             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 460                 


Arg 
465 


<210>  581
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VLVH-CD28H-CD28TM-CD28CS-CD3zICS

<400>  581

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val 
        35                  40                  45              


Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly 
65                  70                  75                  80  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu 
                85                  90                  95      


Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly 
145                 150                 155                 160 


Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp 
                165                 170                 175     


Tyr Gly Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys 
        195                 200                 205             


Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Ser Lys Arg Ser Arg Leu Leu His Ser 
305                 310                 315                 320 


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
                325                 330                 335     


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Leu 
            340                 345                 350         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        355                 360                 365             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    370                 375                 380                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
385                 390                 395                 400 


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                405                 410                 415     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            420                 425                 430         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        435                 440                 445             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 460                 


Arg 
465 


<210>  582
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VHVL-CD28H-CD28TM-CD28CS-CD3zICS

<400>  582

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg 
            20                  25                  30          


Pro Gly Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Gly Ile His Trp Val Lys Gln Ser His Ala Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
                165                 170                 175     


Ser Cys Arg Ala Asn Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys 
        195                 200                 205             


Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His Pro Val Glu Glu Glu 
225                 230                 235                 240 


Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr 
                245                 250                 255     


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Ser Lys Arg Ser Arg Leu Leu His Ser 
305                 310                 315                 320 


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
                325                 330                 335     


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Leu 
            340                 345                 350         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        355                 360                 365             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    370                 375                 380                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
385                 390                 395                 400 


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                405                 410                 415     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            420                 425                 430         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        435                 440                 445             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 460                 


Arg 
465 


<210>  583
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VLVH-CD28H-CD28TM-CD28CS-CD3zICS

<400>  583

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Asn Lys Ser Val 
        35                  40                  45              


Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly 
65                  70                  75                  80  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu 
                85                  90                  95      


Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly 
145                 150                 155                 160 


Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp 
                165                 170                 175     


Tyr Gly Ile His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys 
        195                 200                 205             


Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Ser Lys Arg Ser Arg Leu Leu His Ser 
305                 310                 315                 320 


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
                325                 330                 335     


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Leu 
            340                 345                 350         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        355                 360                 365             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    370                 375                 380                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
385                 390                 395                 400 


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                405                 410                 415     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            420                 425                 430         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        435                 440                 445             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 460                 


Arg 
465 


<210>  584
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm22.84-CD28H-CD28TM-41BBCS-CD3zICS

<400>  584

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
        35                  40                  45              


Ser Asn Tyr Val Asn Tyr Ala Met Gly Trp Phe Arg Gln Phe Pro Gly 
    50                  55                  60                  


Lys Glu Arg Glu Phe Val Ala Ser Ile Ser Trp Ser Ser Val Thr Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Ala His Leu Ala Gln Tyr Ser Asp Tyr 
        115                 120                 125             


Ala Tyr Arg Asp Pro His Gln Phe Gly Ala Trp Gly Gln Gly Thr Gln 
    130                 135                 140                 


Val Thr Val Ser Ser Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
145                 150                 155                 160 


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
                165                 170                 175     


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
            180                 185                 190         


Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        195                 200                 205             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    210                 215                 220                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Leu Arg Val Lys 
225                 230                 235                 240 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
                245                 250                 255     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            260                 265                 270         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
        275                 280                 285             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    290                 295                 300                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
305                 310                 315                 320 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                325                 330                 335     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345                 350 


<210>  585
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm5.38-CD28H-CD28TM-41BBCS-CD3zICS

<400>  585

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asp 
        35                  40                  45              


Asp Asp Tyr Asp Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    50                  55                  60                  


Glu Gly Val Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Asp Phe Phe Arg Trp Asp Ser Gly Ser Tyr Tyr 
        115                 120                 125             


Val Arg Gly Cys Arg His Ala Thr Tyr Asp Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Gln Val Thr Val Ser Ser Val Lys Gly Lys His Leu Cys Pro Ser Pro 
145                 150                 155                 160 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
                165                 170                 175     


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
            180                 185                 190         


Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        195                 200                 205             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    210                 215                 220                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Leu Arg Val 
225                 230                 235                 240 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
                245                 250                 255     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            260                 265                 270         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln 
        275                 280                 285             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    290                 295                 300                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
305                 310                 315                 320 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                325                 330                 335     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345                 350     


<210>  586
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VHVL-CD28H-CD28TM-41BBCS-CD3zICS

<400>  586

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg 
            20                  25                  30          


Pro Gly Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Gly Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
                165                 170                 175     


Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys 
        195                 200                 205             


Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His Pro Val Glu Glu Glu 
225                 230                 235                 240 


Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr 
                245                 250                 255     


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
305                 310                 315                 320 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                325                 330                 335     


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            340                 345                 350         


Leu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
        355                 360                 365             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    370                 375                 380                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
385                 390                 395                 400 


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                405                 410                 415     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            420                 425                 430         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        435                 440                 445             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    450                 455                 460                 


Pro Pro Arg 
465         


<210>  587
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VLVH-CD28H-CD28TM-41BBCS-CD3zICS

<400>  587

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val 
        35                  40                  45              


Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly 
65                  70                  75                  80  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu 
                85                  90                  95      


Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly 
145                 150                 155                 160 


Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp 
                165                 170                 175     


Tyr Gly Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys 
        195                 200                 205             


Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
305                 310                 315                 320 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                325                 330                 335     


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            340                 345                 350         


Leu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
        355                 360                 365             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    370                 375                 380                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
385                 390                 395                 400 


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                405                 410                 415     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            420                 425                 430         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        435                 440                 445             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    450                 455                 460                 


Pro Pro Arg 
465         


<210>  588
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VHVL-CD28H-CD28TM-41BBCS-CD3zICS

<400>  588

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg 
            20                  25                  30          


Pro Gly Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Gly Ile His Trp Val Lys Gln Ser His Ala Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
                165                 170                 175     


Ser Cys Arg Ala Asn Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys 
        195                 200                 205             


Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His Pro Val Glu Glu Glu 
225                 230                 235                 240 


Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr 
                245                 250                 255     


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
305                 310                 315                 320 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                325                 330                 335     


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            340                 345                 350         


Leu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
        355                 360                 365             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    370                 375                 380                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
385                 390                 395                 400 


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                405                 410                 415     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            420                 425                 430         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        435                 440                 445             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    450                 455                 460                 


Pro Pro Arg 
465         


<210>  589
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VLVH-CD28H-CD28TM-41BBCS-CD3zICS

<400>  589

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Asn Lys Ser Val 
        35                  40                  45              


Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly 
65                  70                  75                  80  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu 
                85                  90                  95      


Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly 
145                 150                 155                 160 


Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp 
                165                 170                 175     


Tyr Gly Ile His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys 
        195                 200                 205             


Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
305                 310                 315                 320 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                325                 330                 335     


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            340                 345                 350         


Leu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
        355                 360                 365             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    370                 375                 380                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
385                 390                 395                 400 


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                405                 410                 415     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            420                 425                 430         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        435                 440                 445             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    450                 455                 460                 


Pro Pro Arg 
465         


<210>  590
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm22.84-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  590

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
        35                  40                  45              


Ser Asn Tyr Val Asn Tyr Ala Met Gly Trp Phe Arg Gln Phe Pro Gly 
    50                  55                  60                  


Lys Glu Arg Glu Phe Val Ala Ser Ile Ser Trp Ser Ser Val Thr Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Ala His Leu Ala Gln Tyr Ser Asp Tyr 
        115                 120                 125             


Ala Tyr Arg Asp Pro His Gln Phe Gly Ala Trp Gly Gln Gly Thr Gln 
    130                 135                 140                 


Val Thr Val Ser Ser Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
145                 150                 155                 160 


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
                165                 170                 175     


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
            180                 185                 190         


Trp Val Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly 
        195                 200                 205             


Lys Val Tyr Ile Asn Met Pro Gly Arg Gly Leu Arg Val Lys Phe Ser 
    210                 215                 220                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
225                 230                 235                 240 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                245                 250                 255     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
            260                 265                 270         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        275                 280                 285             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    290                 295                 300                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
305                 310                 315                 320 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                325                 330         


<210>  591
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm5.38-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  591

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asp 
        35                  40                  45              


Asp Asp Tyr Asp Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    50                  55                  60                  


Glu Gly Val Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Asp Phe Phe Arg Trp Asp Ser Gly Ser Tyr Tyr 
        115                 120                 125             


Val Arg Gly Cys Arg His Ala Thr Tyr Asp Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Gln Val Thr Val Ser Ser Val Lys Gly Lys His Leu Cys Pro Ser Pro 
145                 150                 155                 160 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
                165                 170                 175     


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
            180                 185                 190         


Phe Trp Val Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp 
        195                 200                 205             


Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly Leu Arg Val Lys Phe 
    210                 215                 220                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
225                 230                 235                 240 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                245                 250                 255     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
            260                 265                 270         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        275                 280                 285             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    290                 295                 300                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
305                 310                 315                 320 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                325                 330             


<210>  592
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VHVL-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  592

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg 
            20                  25                  30          


Pro Gly Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Gly Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
                165                 170                 175     


Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys 
        195                 200                 205             


Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His Pro Val Glu Glu Glu 
225                 230                 235                 240 


Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr 
                245                 250                 255     


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Leu Cys Ala Arg Pro Arg Arg Ser Pro 
305                 310                 315                 320 


Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly Leu 
                325                 330                 335     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
            340                 345                 350         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        355                 360                 365             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    370                 375                 380                 


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
385                 390                 395                 400 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                405                 410                 415     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            420                 425                 430         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        435                 440                 445             


Arg 
    


<210>  593
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VLVH-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  593

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val 
        35                  40                  45              


Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly 
65                  70                  75                  80  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu 
                85                  90                  95      


Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly 
145                 150                 155                 160 


Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp 
                165                 170                 175     


Tyr Gly Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys 
        195                 200                 205             


Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Leu Cys Ala Arg Pro Arg Arg Ser Pro 
305                 310                 315                 320 


Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly Leu 
                325                 330                 335     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
            340                 345                 350         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        355                 360                 365             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    370                 375                 380                 


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
385                 390                 395                 400 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                405                 410                 415     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            420                 425                 430         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        435                 440                 445             


Arg 
    


<210>  594
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VHVL-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  594

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg 
            20                  25                  30          


Pro Gly Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Gly Ile His Trp Val Lys Gln Ser His Ala Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
                165                 170                 175     


Ser Cys Arg Ala Asn Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys 
        195                 200                 205             


Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His Pro Val Glu Glu Glu 
225                 230                 235                 240 


Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr 
                245                 250                 255     


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Leu Cys Ala Arg Pro Arg Arg Ser Pro 
305                 310                 315                 320 


Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly Leu 
                325                 330                 335     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
            340                 345                 350         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        355                 360                 365             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    370                 375                 380                 


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
385                 390                 395                 400 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                405                 410                 415     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            420                 425                 430         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        435                 440                 445             


Arg 
    


<210>  595
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VLVH-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  595

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Asn Lys Ser Val 
        35                  40                  45              


Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly 
65                  70                  75                  80  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu 
                85                  90                  95      


Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly 
145                 150                 155                 160 


Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp 
                165                 170                 175     


Tyr Gly Ile His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys 
        195                 200                 205             


Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Val Lys Gly Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Leu Cys Ala Arg Pro Arg Arg Ser Pro 
305                 310                 315                 320 


Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly Leu 
                325                 330                 335     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
            340                 345                 350         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        355                 360                 365             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    370                 375                 380                 


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
385                 390                 395                 400 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                405                 410                 415     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            420                 425                 430         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        435                 440                 445             


Arg 
 
   

<210> 596

<400> 596
000

<210> 597

<400> 597
000

<210> 598

<400> 598
000

<210> 599

<400> 599
000

<210> 600

<400> 600
000

<210> 601

<400> 601
000

<210> 602

<400> 602
000

<210> 603

<400> 603
000

<210> 604

<400> 604
000

<210> 605

<400> 605
000

<210> 606

<400> 606
000

<210> 607

<400> 607
000

<210> 608

<400> 608
000

<210> 609

<400> 609
000

<210> 610

<400> 610
000

<210> 611

<400> 611
000

<210> 612

<400> 612
000

<210> 613

<400> 613
000

<210> 614

<400> 614
000

<210> 615

<400> 615
000

<210> 616

<400> 616
000

<210> 617

<400> 617
000

<210> 618

<400> 618
000

<210> 619

<400> 619
000

<210> 620

<400> 620
000

<210> 621

<400> 621
000

<210> 622

<400> 622
000

<210> 623

<400> 623
000

<210> 624

<400> 624
000

<210> 625

<400> 625
000

<210> 626

<400> 626
000

<210> 627

<400> 627
000

<210> 628

<400> 628
000

<210> 629

<400> 629
000

<210> 630

<400> 630
000

<210> 631

<400> 631
000

<210> 632

<400> 632
000

<210> 633

<400> 633
000

<210> 634

<400> 634
000

<210> 635

<400> 635
000

<210> 636

<400> 636
000

<210> 637

<400> 637
000

<210> 638

<400> 638
000

<210> 639

<400> 639
000

<210> 640

<400> 640
000

<210> 641

<400> 641
000

<210> 642

<400> 642
000

<210> 643

<400> 643
000

<210> 644

<400> 644
000

<210> 645

<400> 645
000

<210> 646

<400> 646
000

<210> 647

<400> 647
000

<210> 648

<400> 648
000

<210> 649

<400> 649
000

<210> 650

<400> 650
000

<210> 651

<400> 651
000

<210> 652

<400> 652
000

<210> 653

<400> 653
000

<210> 654

<400> 654
000

<210> 655

<400> 655
000

<210> 656

<400> 656
000

<210> 657

<400> 657
000

<210> 658

<400> 658
000

<210> 659

<400> 659
000

<210> 660

<400> 660
000

<210> 661

<400> 661
000

<210> 662

<400> 662
000

<210> 663

<400> 663
000

<210> 664

<400> 664
000

<210> 665

<400> 665
000

<210> 666

<400> 666
000

<210> 667

<400> 667
000

<210> 668

<400> 668
000

<210> 669

<400> 669
000

<210> 670

<400> 670
000

<210> 671

<400> 671
000

<210> 672

<400> 672
000

<210> 673

<400> 673
000

<210> 674

<400> 674
000

<210> 675

<400> 675
000

<210> 676

<400> 676
000

<210> 677

<400> 677
000


<210>  678
<211>  1047
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm22.84-CD28H-CD28TM-CD28CS-CD3zICS

<400>  678
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gttcagctgc aagagtctgg cggaggactg gttcaacctg gcggaagcct gagactgtct      120

tgtgccgctt ctggcagaac cttcagcaac tacgtgaact acgccatggg ctggttcaga      180

cagttccccg gcaaagagag agagttcgtc gccagcatca gctggtctag cgtgaccacc      240

tactacgccg acagcgtgaa gggcagattc accatcagca gagacaacgc caagaacacc      300

gtgtacctgc agatgaacag cctgaagcca gaggacaccg ccgtgtacta ctgtgctgct      360

cacctggctc agtacagcga ctacgcctac agagatcccc accagtttgg cgcttggggc      420

cagggaacac aagtgaccgt tagctctgtg aaagggaaac acctttgtcc aagtccccta      480

tttcccggac cttctaagcc cttttgggtg ctggtggtgg ttggtggagt cctggcttgc      540

tatagcttgc tagtaacagt ggcctttatt attttctggg tgaggagtaa gaggagcagg      600

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat      660

taccagccct atgccccacc acgcgacttc gcagcctatc gctcccttag agtgaagttc      720

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc      780

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag      840

atggggggaa agccgcagag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag      900

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc      960

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1020

cttcacatgc aggccctgcc ccctcgc                                         1047


<210>  679
<211>  1050
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm5.38-CD28H-CD28TM-CD28CS-CD3zICS

<400>  679
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gttcagctgc aagagtctgg cggaggactg gttcaagctg gcggaagcct gagactgtct      120

tgtgccgctt ctggcttcac cgacgacgac tacgatatcg gctggttcag acaggcccct      180

ggcaaagaga gagagggcgt cagctgtatc agcagctctg acggctctac ctactacgcc      240

gacagcgtga agggcagatt caccatcagc agcgacaacg ccaagaacac cgtgtacctg      300

cagatgaact ctctgaagcc cgaggacacc gccgtgtact actgtgccgc cgacttcttc      360

agatgggaca gcggcagcta ctacgtgcgg ggatgtagac acgccaccta cgattactgg      420

ggccagggca cacaagtgac cgtgtcatct gtgaaaggga aacacctttg tccaagtccc      480

ctatttcccg gaccttctaa gcccttttgg gtgctggtgg tggttggtgg agtcctggct      540

tgctatagct tgctagtaac agtggccttt attattttct gggtgaggag taagaggagc      600

aggctcctgc acagtgacta catgaacatg actccccgcc gccccgggcc cacccgcaag      660

cattaccagc cctatgcccc accacgcgac ttcgcagcct atcgctccct tagagtgaag      720

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag      780

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct      840

gagatggggg gaaagccgca gagaaggaag aaccctcagg aaggcctgta caatgaactg      900

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg      960

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1020

gcccttcaca tgcaggccct gccccctcgc                                      1050


<210>  680
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VHVL-CD28H-CD28TM-CD28CS-CD3zICS

<400>  680
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gtccagctgc agcagtctgg gcctgaggtg gtgaggcctg gggtctcagt gaagatttcc      120

tgcaagggtt ccggctacac attcactgat tatggtatgc actgggtgaa gcagagtcat      180

gcaaagagtc tagagtggat tggagttatt agtacttaca atggttatac aaactacaac      240

cagaagttta agggcaaggc cacaatgact gtagacaaat cctccagcac agcctatatg      300

gaacttgcca gattgacatc tgaggattct gccatctatt actgtgcaag agcctactat      360

ggtaaccttt actatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      420

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgacat tgtgctgaca      480

cagtctcctg cttccttagc tgtatctctg gggcagaggg ccaccatctc atgcagggcc      540

agcaaaagtg tcagtacatc tagctatagt tatatgcact ggtaccaaca gaaaccagga      600

cagccaccca aactcctcat caagtatgca tccaacctag aatctggggt ccctgccagg      660

ttcagtggca gtgggtctgg gacagacttc atcctcaaca tccatccagt ggaggaggag      720

gatgctgcaa cctattactg tcagcacagt agggagcttc cattcacgtt cggctcgggg      780

acaaagttgg aaataaaagt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgaggagta agaggagcag gctcctgcac      960

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc     1020

tatgccccac cacgcgactt cgcagcctat cgctccctta gagtgaagtt cagcaggagc     1080

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1140

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     1200

aagccgcaga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1260

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1320

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1380

caggccctgc cccctcgc                                                   1398


<210>  681
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VLVH-CD28H-CD28TM-CD28CS-CD3zICS

<400>  681
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagcgac       60

attgtgctga cacagtctcc tgcttcctta gctgtatctc tggggcagag ggccaccatc      120

tcatgcaggg ccagcaaaag tgtcagtaca tctagctata gttatatgca ctggtaccaa      180

cagaaaccag gacagccacc caaactcctc atcaagtatg catccaacct agaatctggg      240

gtccctgcca ggttcagtgg cagtgggtct gggacagact tcatcctcaa catccatcca      300

gtggaggagg aggatgctgc aacctattac tgtcagcaca gtagggagct tccattcacg      360

ttcggctcgg ggacaaagtt ggaaataaaa ggtggtggtg gttctggcgg cggcggctcc      420

ggtggtggtg gttcccaggt ccagctgcag cagtctgggc ctgaggtggt gaggcctggg      480

gtctcagtga agatttcctg caagggttcc ggctacacat tcactgatta tggtatgcac      540

tgggtgaagc agagtcatgc aaagagtcta gagtggattg gagttattag tacttacaat      600

ggttatacaa actacaacca gaagtttaag ggcaaggcca caatgactgt agacaaatcc      660

tccagcacag cctatatgga acttgccaga ttgacatctg aggattctgc catctattac      720

tgtgcaagag cctactatgg taacctttac tatgctatgg actactgggg tcaaggaacc      780

tcagtcaccg tctcctcagt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgaggagta agaggagcag gctcctgcac      960

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc     1020

tatgccccac cacgcgactt cgcagcctat cgctccctta gagtgaagtt cagcaggagc     1080

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1140

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     1200

aagccgcaga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1260

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1320

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1380

caggccctgc cccctcgc                                                   1398


<210>  682
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VHVL-CD28H-CD28TM-CD28CS-CD3zICS

<400>  682
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gtccagctgc agcagtctgg gcctgaggtg gtgaggcctg gggtctcagt gaagatttcc      120

tgcaagggtt ccggctacac attcactgat tatggtatac actgggtgaa gcagagtcat      180

gcaaagagtc tagagtggat tggagttatt agtacttaca atggttatac aaactacaac      240

cagaagttta agggcaaggc cacaatgact gtagacaaat cctccagcac agcctatatg      300

gaacttgcca gattgacatc tgaggattct gccatctatt actgtgcaag agcctactat      360

ggtaaccttt actatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      420

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgacat tgtgctgaca      480

cagtctcctg cttccttagc tgtatctctg gggcagaggg ccaccatctc atgcagggcc      540

aacaaaagtg tcagtacatc tagctatagt tatatgcact ggtaccaaca gaaaccagga      600

cagccaccca aactcctcat caagtatgca tccaacctag aatctggggt ccctgccagg      660

ttcagtggca gtgggtctgg gacagacttc atcctcaaca tccatccagt ggaggaggag      720

gatgctgcaa cctattactg tcagcacagt agggagcttc cattcacgtt cggctcgggg      780

acaaagttgg aaataaaagt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgaggagta agaggagcag gctcctgcac      960

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc     1020

tatgccccac cacgcgactt cgcagcctat cgctccctta gagtgaagtt cagcaggagc     1080

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1140

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     1200

aagccgcaga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1260

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1320

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1380

caggccctgc cccctcgc                                                   1398


<210>  683
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VLVH-CD28H-CD28TM-CD28CS-CD3zICS

<400>  683
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagcgac       60

attgtgctga cacagtctcc tgcttcctta gctgtatctc tggggcagag ggccaccatc      120

tcatgcaggg ccaacaaaag tgtcagtaca tctagctata gttatatgca ctggtaccaa      180

cagaaaccag gacagccacc caaactcctc atcaagtatg catccaacct agaatctggg      240

gtccctgcca ggttcagtgg cagtgggtct gggacagact tcatcctcaa catccatcca      300

gtggaggagg aggatgctgc aacctattac tgtcagcaca gtagggagct tccattcacg      360

ttcggctcgg ggacaaagtt ggaaataaaa ggtggtggtg gttctggcgg cggcggctcc      420

ggtggtggtg gttcccaggt ccagctgcag cagtctgggc ctgaggtggt gaggcctggg      480

gtctcagtga agatttcctg caagggttcc ggctacacat tcactgatta tggtatacac      540

tgggtgaagc agagtcatgc aaagagtcta gagtggattg gagttattag tacttacaat      600

ggttatacaa actacaacca gaagtttaag ggcaaggcca caatgactgt agacaaatcc      660

tccagcacag cctatatgga acttgccaga ttgacatctg aggattctgc catctattac      720

tgtgcaagag cctactatgg taacctttac tatgctatgg actactgggg tcaaggaacc      780

tcagtcaccg tctcctcagt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgaggagta agaggagcag gctcctgcac      960

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc     1020

tatgccccac cacgcgactt cgcagcctat cgctccctta gagtgaagtt cagcaggagc     1080

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1140

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     1200

aagccgcaga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1260

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1320

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1380

caggccctgc cccctcgc                                                   1398


<210>  684
<211>  1050
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm22.84-CD28H-CD28TM-41BBCS-CD3zICS

<400>  684
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gttcagctgc aagagtctgg cggaggactg gttcaacctg gcggaagcct gagactgtct      120

tgtgccgctt ctggcagaac cttcagcaac tacgtgaact acgccatggg ctggttcaga      180

cagttccccg gcaaagagag agagttcgtc gccagcatca gctggtctag cgtgaccacc      240

tactacgccg acagcgtgaa gggcagattc accatcagca gagacaacgc caagaacacc      300

gtgtacctgc agatgaacag cctgaagcca gaggacaccg ccgtgtacta ctgtgctgct      360

cacctggctc agtacagcga ctacgcctac agagatcccc accagtttgg cgcttggggc      420

cagggaacac aagtgaccgt tagctctgtg aaagggaaac acctttgtcc aagtccccta      480

tttcccggac cttctaagcc cttttgggtg ctggtggtgg ttggtggagt cctggcttgc      540

tatagcttgc tagtaacagt ggcctttatt attttctggg tgaaacgggg cagaaagaaa      600

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat      660

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgct tagagtgaag      720

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag      780

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct      840

gagatggggg gaaagccgca gagaaggaag aaccctcagg aaggcctgta caatgaactg      900

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg      960

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1020

gcccttcaca tgcaggccct gccccctcgc                                      1050


<210>  685
<211>  1053
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm5.38-CD28H-CD28TM-41BBCS-CD3zICS

<400>  685
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gttcagctgc aagagtctgg cggaggactg gttcaagctg gcggaagcct gagactgtct      120

tgtgccgctt ctggcttcac cgacgacgac tacgatatcg gctggttcag acaggcccct      180

ggcaaagaga gagagggcgt cagctgtatc agcagctctg acggctctac ctactacgcc      240

gacagcgtga agggcagatt caccatcagc agcgacaacg ccaagaacac cgtgtacctg      300

cagatgaact ctctgaagcc cgaggacacc gccgtgtact actgtgccgc cgacttcttc      360

agatgggaca gcggcagcta ctacgtgcgg ggatgtagac acgccaccta cgattactgg      420

ggccagggca cacaagtgac cgtgtcatct gtgaaaggga aacacctttg tccaagtccc      480

ctatttcccg gaccttctaa gcccttttgg gtgctggtgg tggttggtgg agtcctggct      540

tgctatagct tgctagtaac agtggccttt attattttct gggtgaaacg gggcagaaag      600

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa      660

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gcttagagtg      720

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac      780

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac      840

cctgagatgg ggggaaagcc gcagagaagg aagaaccctc aggaaggcct gtacaatgaa      900

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg      960

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     1020

gacgcccttc acatgcaggc cctgccccct cgc                                  1053


<210>  686
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VHVL-CD28H-CD28TM-41BBCS-CD3zICS

<400>  686
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gtccagctgc agcagtctgg gcctgaggtg gtgaggcctg gggtctcagt gaagatttcc      120

tgcaagggtt ccggctacac attcactgat tatggtatgc actgggtgaa gcagagtcat      180

gcaaagagtc tagagtggat tggagttatt agtacttaca atggttatac aaactacaac      240

cagaagttta agggcaaggc cacaatgact gtagacaaat cctccagcac agcctatatg      300

gaacttgcca gattgacatc tgaggattct gccatctatt actgtgcaag agcctactat      360

ggtaaccttt actatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      420

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgacat tgtgctgaca      480

cagtctcctg cttccttagc tgtatctctg gggcagaggg ccaccatctc atgcagggcc      540

agcaaaagtg tcagtacatc tagctatagt tatatgcact ggtaccaaca gaaaccagga      600

cagccaccca aactcctcat caagtatgca tccaacctag aatctggggt ccctgccagg      660

ttcagtggca gtgggtctgg gacagacttc atcctcaaca tccatccagt ggaggaggag      720

gatgctgcaa cctattactg tcagcacagt agggagcttc cattcacgtt cggctcgggg      780

acaaagttgg aaataaaagt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgaaacggg gcagaaagaa actcctgtat      960

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     1020

tgccgatttc cagaagaaga agaaggagga tgtgaactgc ttagagtgaa gttcagcagg     1080

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1140

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1200

ggaaagccgc agagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1260

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1320

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1380

atgcaggccc tgccccctcg c                                               1401


<210>  687
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VLVH-CD28H-CD28TM-41BBCS-CD3zICS

<400>  687
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagcgac       60

attgtgctga cacagtctcc tgcttcctta gctgtatctc tggggcagag ggccaccatc      120

tcatgcaggg ccagcaaaag tgtcagtaca tctagctata gttatatgca ctggtaccaa      180

cagaaaccag gacagccacc caaactcctc atcaagtatg catccaacct agaatctggg      240

gtccctgcca ggttcagtgg cagtgggtct gggacagact tcatcctcaa catccatcca      300

gtggaggagg aggatgctgc aacctattac tgtcagcaca gtagggagct tccattcacg      360

ttcggctcgg ggacaaagtt ggaaataaaa ggtggtggtg gttctggcgg cggcggctcc      420

ggtggtggtg gttcccaggt ccagctgcag cagtctgggc ctgaggtggt gaggcctggg      480

gtctcagtga agatttcctg caagggttcc ggctacacat tcactgatta tggtatgcac      540

tgggtgaagc agagtcatgc aaagagtcta gagtggattg gagttattag tacttacaat      600

ggttatacaa actacaacca gaagtttaag ggcaaggcca caatgactgt agacaaatcc      660

tccagcacag cctatatgga acttgccaga ttgacatctg aggattctgc catctattac      720

tgtgcaagag cctactatgg taacctttac tatgctatgg actactgggg tcaaggaacc      780

tcagtcaccg tctcctcagt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgaaacggg gcagaaagaa actcctgtat      960

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     1020

tgccgatttc cagaagaaga agaaggagga tgtgaactgc ttagagtgaa gttcagcagg     1080

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1140

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1200

ggaaagccgc agagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1260

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1320

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1380

atgcaggccc tgccccctcg c                                               1401


<210>  688
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VHVL-CD28H-CD28TM-41BBCS-CD3zICS

<400>  688
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gtccagctgc agcagtctgg gcctgaggtg gtgaggcctg gggtctcagt gaagatttcc      120

tgcaagggtt ccggctacac attcactgat tatggtatac actgggtgaa gcagagtcat      180

gcaaagagtc tagagtggat tggagttatt agtacttaca atggttatac aaactacaac      240

cagaagttta agggcaaggc cacaatgact gtagacaaat cctccagcac agcctatatg      300

gaacttgcca gattgacatc tgaggattct gccatctatt actgtgcaag agcctactat      360

ggtaaccttt actatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      420

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgacat tgtgctgaca      480

cagtctcctg cttccttagc tgtatctctg gggcagaggg ccaccatctc atgcagggcc      540

aacaaaagtg tcagtacatc tagctatagt tatatgcact ggtaccaaca gaaaccagga      600

cagccaccca aactcctcat caagtatgca tccaacctag aatctggggt ccctgccagg      660

ttcagtggca gtgggtctgg gacagacttc atcctcaaca tccatccagt ggaggaggag      720

gatgctgcaa cctattactg tcagcacagt agggagcttc cattcacgtt cggctcgggg      780

acaaagttgg aaataaaagt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgaaacggg gcagaaagaa actcctgtat      960

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     1020

tgccgatttc cagaagaaga agaaggagga tgtgaactgc ttagagtgaa gttcagcagg     1080

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1140

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1200

ggaaagccgc agagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1260

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1320

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1380

atgcaggccc tgccccctcg c                                               1401


<210>  689
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VLVH-CD28H-CD28TM-41BBCS-CD3zICS

<400>  689
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagcgac       60

attgtgctga cacagtctcc tgcttcctta gctgtatctc tggggcagag ggccaccatc      120

tcatgcaggg ccaacaaaag tgtcagtaca tctagctata gttatatgca ctggtaccaa      180

cagaaaccag gacagccacc caaactcctc atcaagtatg catccaacct agaatctggg      240

gtccctgcca ggttcagtgg cagtgggtct gggacagact tcatcctcaa catccatcca      300

gtggaggagg aggatgctgc aacctattac tgtcagcaca gtagggagct tccattcacg      360

ttcggctcgg ggacaaagtt ggaaataaaa ggtggtggtg gttctggcgg cggcggctcc      420

ggtggtggtg gttcccaggt ccagctgcag cagtctgggc ctgaggtggt gaggcctggg      480

gtctcagtga agatttcctg caagggttcc ggctacacat tcactgatta tggtatacac      540

tgggtgaagc agagtcatgc aaagagtcta gagtggattg gagttattag tacttacaat      600

ggttatacaa actacaacca gaagtttaag ggcaaggcca caatgactgt agacaaatcc      660

tccagcacag cctatatgga acttgccaga ttgacatctg aggattctgc catctattac      720

tgtgcaagag cctactatgg taacctttac tatgctatgg actactgggg tcaaggaacc      780

tcagtcaccg tctcctcagt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgaaacggg gcagaaagaa actcctgtat      960

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     1020

tgccgatttc cagaagaaga agaaggagga tgtgaactgc ttagagtgaa gttcagcagg     1080

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1140

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1200

ggaaagccgc agagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1260

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1320

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1380

atgcaggccc tgccccctcg c                                               1401


<210>  690
<211>  996
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm22.84-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  690
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gttcagctgc aagagtctgg cggaggactg gttcaacctg gcggaagcct gagactgtct      120

tgtgccgctt ctggcagaac cttcagcaac tacgtgaact acgccatggg ctggttcaga      180

cagttccccg gcaaagagag agagttcgtc gccagcatca gctggtctag cgtgaccacc      240

tactacgccg acagcgtgaa gggcagattc accatcagca gagacaacgc caagaacacc      300

gtgtacctgc agatgaacag cctgaagcca gaggacaccg ccgtgtacta ctgtgctgct      360

cacctggctc agtacagcga ctacgcctac agagatcccc accagtttgg cgcttggggc      420

cagggaacac aagtgaccgt tagctctgtg aaagggaaac acctttgtcc aagtccccta      480

tttcccggac cttctaagcc cttttgggtg ctggtggtgg ttggtggagt cctggcttgc      540

tatagcttgc tagtaacagt ggcctttatt attttctggg tgctgtgcgc acgcccacgc      600

cgcagccccg cccaagaaga tggcaaagtc tacatcaaca tgccaggcag gggccttaga      660

gtgaagttca gcaggagcgc agacgccccc gcgtaccagc agggccagaa ccagctctat      720

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg      780

gaccctgaga tggggggaaa gccgcagaga aggaagaacc ctcaggaagg cctgtacaat      840

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      900

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      960

tacgacgccc ttcacatgca ggccctgccc cctcgc                                996


<210>  691
<211>  999
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm5.38-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  691
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gttcagctgc aagagtctgg cggaggactg gttcaagctg gcggaagcct gagactgtct      120

tgtgccgctt ctggcttcac cgacgacgac tacgatatcg gctggttcag acaggcccct      180

ggcaaagaga gagagggcgt cagctgtatc agcagctctg acggctctac ctactacgcc      240

gacagcgtga agggcagatt caccatcagc agcgacaacg ccaagaacac cgtgtacctg      300

cagatgaact ctctgaagcc cgaggacacc gccgtgtact actgtgccgc cgacttcttc      360

agatgggaca gcggcagcta ctacgtgcgg ggatgtagac acgccaccta cgattactgg      420

ggccagggca cacaagtgac cgtgtcatct gtgaaaggga aacacctttg tccaagtccc      480

ctatttcccg gaccttctaa gcccttttgg gtgctggtgg tggttggtgg agtcctggct      540

tgctatagct tgctagtaac agtggccttt attattttct gggtgctgtg cgcacgccca      600

cgccgcagcc ccgcccaaga agatggcaaa gtctacatca acatgccagg caggggcctt      660

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc      720

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      780

cgggaccctg agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac      840

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag      900

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac      960

acctacgacg cccttcacat gcaggccctg ccccctcgc                             999


<210>  692
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VHVL-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  692
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gtccagctgc agcagtctgg gcctgaggtg gtgaggcctg gggtctcagt gaagatttcc      120

tgcaagggtt ccggctacac attcactgat tatggtatgc actgggtgaa gcagagtcat      180

gcaaagagtc tagagtggat tggagttatt agtacttaca atggttatac aaactacaac      240

cagaagttta agggcaaggc cacaatgact gtagacaaat cctccagcac agcctatatg      300

gaacttgcca gattgacatc tgaggattct gccatctatt actgtgcaag agcctactat      360

ggtaaccttt actatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      420

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgacat tgtgctgaca      480

cagtctcctg cttccttagc tgtatctctg gggcagaggg ccaccatctc atgcagggcc      540

agcaaaagtg tcagtacatc tagctatagt tatatgcact ggtaccaaca gaaaccagga      600

cagccaccca aactcctcat caagtatgca tccaacctag aatctggggt ccctgccagg      660

ttcagtggca gtgggtctgg gacagacttc atcctcaaca tccatccagt ggaggaggag      720

gatgctgcaa cctattactg tcagcacagt agggagcttc cattcacgtt cggctcgggg      780

acaaagttgg aaataaaagt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgctgtgcg cacgcccacg ccgcagcccc      960

gcccaagaag atggcaaagt ctacatcaac atgccaggca ggggccttag agtgaagttc     1020

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc     1080

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1140

atggggggaa agccgcagag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1200

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1260

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1320

cttcacatgc aggccctgcc ccctcgc                                         1347


<210>  693
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VLVH-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  693
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagcgac       60

attgtgctga cacagtctcc tgcttcctta gctgtatctc tggggcagag ggccaccatc      120

tcatgcaggg ccagcaaaag tgtcagtaca tctagctata gttatatgca ctggtaccaa      180

cagaaaccag gacagccacc caaactcctc atcaagtatg catccaacct agaatctggg      240

gtccctgcca ggttcagtgg cagtgggtct gggacagact tcatcctcaa catccatcca      300

gtggaggagg aggatgctgc aacctattac tgtcagcaca gtagggagct tccattcacg      360

ttcggctcgg ggacaaagtt ggaaataaaa ggtggtggtg gttctggcgg cggcggctcc      420

ggtggtggtg gttcccaggt ccagctgcag cagtctgggc ctgaggtggt gaggcctggg      480

gtctcagtga agatttcctg caagggttcc ggctacacat tcactgatta tggtatgcac      540

tgggtgaagc agagtcatgc aaagagtcta gagtggattg gagttattag tacttacaat      600

ggttatacaa actacaacca gaagtttaag ggcaaggcca caatgactgt agacaaatcc      660

tccagcacag cctatatgga acttgccaga ttgacatctg aggattctgc catctattac      720

tgtgcaagag cctactatgg taacctttac tatgctatgg actactgggg tcaaggaacc      780

tcagtcaccg tctcctcagt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgctgtgcg cacgcccacg ccgcagcccc      960

gcccaagaag atggcaaagt ctacatcaac atgccaggca ggggccttag agtgaagttc     1020

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc     1080

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1140

atggggggaa agccgcagag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1200

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1260

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1320

cttcacatgc aggccctgcc ccctcgc                                         1347


<210>  694
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VHVL-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  694
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gtccagctgc agcagtctgg gcctgaggtg gtgaggcctg gggtctcagt gaagatttcc      120

tgcaagggtt ccggctacac attcactgat tatggtatac actgggtgaa gcagagtcat      180

gcaaagagtc tagagtggat tggagttatt agtacttaca atggttatac aaactacaac      240

cagaagttta agggcaaggc cacaatgact gtagacaaat cctccagcac agcctatatg      300

gaacttgcca gattgacatc tgaggattct gccatctatt actgtgcaag agcctactat      360

ggtaaccttt actatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      420

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgacat tgtgctgaca      480

cagtctcctg cttccttagc tgtatctctg gggcagaggg ccaccatctc atgcagggcc      540

aacaaaagtg tcagtacatc tagctatagt tatatgcact ggtaccaaca gaaaccagga      600

cagccaccca aactcctcat caagtatgca tccaacctag aatctggggt ccctgccagg      660

ttcagtggca gtgggtctgg gacagacttc atcctcaaca tccatccagt ggaggaggag      720

gatgctgcaa cctattactg tcagcacagt agggagcttc cattcacgtt cggctcgggg      780

acaaagttgg aaataaaagt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgctgtgcg cacgcccacg ccgcagcccc      960

gcccaagaag atggcaaagt ctacatcaac atgccaggca ggggccttag agtgaagttc     1020

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc     1080

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1140

atggggggaa agccgcagag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1200

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1260

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1320

cttcacatgc aggccctgcc ccctcgc                                         1347


<210>  695
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VLVH-CD28H-CD28TM-DAP10CS-CD3zICS

<400>  695
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagcgac       60

attgtgctga cacagtctcc tgcttcctta gctgtatctc tggggcagag ggccaccatc      120

tcatgcaggg ccaacaaaag tgtcagtaca tctagctata gttatatgca ctggtaccaa      180

cagaaaccag gacagccacc caaactcctc atcaagtatg catccaacct agaatctggg      240

gtccctgcca ggttcagtgg cagtgggtct gggacagact tcatcctcaa catccatcca      300

gtggaggagg aggatgctgc aacctattac tgtcagcaca gtagggagct tccattcacg      360

ttcggctcgg ggacaaagtt ggaaataaaa ggtggtggtg gttctggcgg cggcggctcc      420

ggtggtggtg gttcccaggt ccagctgcag cagtctgggc ctgaggtggt gaggcctggg      480

gtctcagtga agatttcctg caagggttcc ggctacacat tcactgatta tggtatacac      540

tgggtgaagc agagtcatgc aaagagtcta gagtggattg gagttattag tacttacaat      600

ggttatacaa actacaacca gaagtttaag ggcaaggcca caatgactgt agacaaatcc      660

tccagcacag cctatatgga acttgccaga ttgacatctg aggattctgc catctattac      720

tgtgcaagag cctactatgg taacctttac tatgctatgg actactgggg tcaaggaacc      780

tcagtcaccg tctcctcagt gaaagggaaa cacctttgtc caagtcccct atttcccgga      840

ccttctaagc ccttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      900

ctagtaacag tggcctttat tattttctgg gtgctgtgcg cacgcccacg ccgcagcccc      960

gcccaagaag atggcaaagt ctacatcaac atgccaggca ggggccttag agtgaagttc     1020

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc     1080

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1140

atggggggaa agccgcagag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1200

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1260

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1320

cttcacatgc aggccctgcc ccctcgc                                         1347



<210> 696

<400> 696
000

<210> 697

<400> 697
000

<210> 698

<400> 698
000

<210> 699

<400> 699
000

<210> 700

<400> 700
000


<210>  701
<211>  1456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CD206

<400>  701

Met Arg Leu Leu Leu Leu Leu Ala Phe Ile Ser Val Ile Pro Val Ser 
1               5                   10                  15      


Val Gln Leu Leu Asp Ala Arg Gln Phe Leu Ile Tyr Asn Glu Asp His 
            20                  25                  30          


Lys Arg Cys Val Asp Ala Leu Ser Ala Ile Ser Val Gln Thr Ala Thr 
        35                  40                  45              


Cys Asn Pro Glu Ala Glu Ser Gln Lys Phe Arg Trp Val Ser Asp Ser 
    50                  55                  60                  


Gln Ile Met Ser Val Ala Phe Lys Leu Cys Leu Gly Val Pro Ser Lys 
65                  70                  75                  80  


Thr Asp Trp Ala Ser Val Thr Leu Tyr Ala Cys Asp Ser Lys Ser Glu 
                85                  90                  95      


Tyr Gln Lys Trp Glu Cys Lys Asn Asp Thr Leu Phe Gly Ile Lys Gly 
            100                 105                 110         


Thr Glu Leu Tyr Phe Asn Tyr Gly Asn Arg Gln Glu Lys Asn Ile Lys 
        115                 120                 125             


Leu Tyr Lys Gly Ser Gly Leu Trp Ser Arg Trp Lys Val Tyr Gly Thr 
    130                 135                 140                 


Thr Asp Asp Leu Cys Ser Arg Gly Tyr Glu Ala Met Tyr Ser Leu Leu 
145                 150                 155                 160 


Gly Asn Ala Asn Gly Ala Val Cys Ala Phe Pro Phe Lys Phe Glu Asn 
                165                 170                 175     


Lys Trp Tyr Ala Asp Cys Thr Ser Ala Gly Arg Ser Asp Gly Trp Leu 
            180                 185                 190         


Trp Cys Gly Thr Thr Thr Asp Tyr Asp Lys Asp Lys Leu Phe Gly Phe 
        195                 200                 205             


Cys Pro Leu His Phe Glu Gly Ser Glu Arg Leu Trp Asn Lys Asp Pro 
    210                 215                 220                 


Leu Thr Gly Ile Leu Tyr Gln Ile Asn Ser Lys Ser Ala Leu Thr Trp 
225                 230                 235                 240 


His Gln Ala Arg Ala Ser Cys Lys Gln Gln Asn Ala Asp Leu Leu Ser 
                245                 250                 255     


Val Thr Glu Ile His Glu Gln Met Tyr Leu Thr Gly Leu Thr Ser Ser 
            260                 265                 270         


Leu Ser Ser Gly Leu Trp Ile Gly Leu Asn Ser Leu Ser Val Arg Ser 
        275                 280                 285             


Gly Trp Gln Trp Ala Gly Gly Ser Pro Phe Arg Tyr Leu Asn Trp Leu 
    290                 295                 300                 


Pro Gly Ser Pro Ser Ser Glu Pro Gly Lys Ser Cys Val Ser Leu Asn 
305                 310                 315                 320 


Pro Gly Lys Asn Ala Lys Trp Glu Asn Leu Glu Cys Val Gln Lys Leu 
                325                 330                 335     


Gly Tyr Ile Cys Lys Lys Gly Asn Asn Thr Leu Asn Pro Phe Ile Ile 
            340                 345                 350         


Pro Ser Ala Ser Asp Val Pro Thr Gly Cys Pro Asn Gln Trp Trp Pro 
        355                 360                 365             


Tyr Ala Gly His Cys Tyr Arg Ile His Arg Glu Glu Lys Lys Ile Gln 
    370                 375                 380                 


Lys Tyr Ala Leu Gln Ala Cys Arg Lys Glu Gly Gly Asp Leu Ala Ser 
385                 390                 395                 400 


Ile His Ser Ile Glu Glu Phe Asp Phe Ile Phe Ser Gln Leu Gly Tyr 
                405                 410                 415     


Glu Pro Asn Asp Glu Leu Trp Ile Gly Leu Asn Asp Ile Lys Ile Gln 
            420                 425                 430         


Met Tyr Phe Glu Trp Ser Asp Gly Thr Pro Val Thr Phe Thr Lys Trp 
        435                 440                 445             


Leu Pro Gly Glu Pro Ser His Glu Asn Asn Arg Gln Glu Asp Cys Val 
    450                 455                 460                 


Val Met Lys Gly Lys Asp Gly Tyr Trp Ala Asp Arg Ala Cys Glu Gln 
465                 470                 475                 480 


Pro Leu Gly Tyr Ile Cys Lys Met Val Ser Gln Ser His Ala Val Val 
                485                 490                 495     


Pro Glu Gly Ala Asp Lys Gly Cys Arg Lys Gly Trp Lys Arg His Gly 
            500                 505                 510         


Phe Tyr Cys Tyr Leu Ile Gly Ser Thr Leu Ser Thr Phe Thr Asp Ala 
        515                 520                 525             


Asn His Thr Cys Thr Asn Glu Lys Ala Tyr Leu Thr Thr Val Glu Asp 
    530                 535                 540                 


Arg Tyr Glu Gln Ala Phe Leu Thr Ser Leu Val Gly Leu Arg Pro Glu 
545                 550                 555                 560 


Lys Tyr Phe Trp Thr Gly Leu Ser Asp Val Gln Asn Lys Gly Thr Phe 
                565                 570                 575     


Arg Trp Thr Val Asp Glu Gln Val Gln Phe Thr His Trp Asn Ala Asp 
            580                 585                 590         


Met Pro Gly Arg Lys Ala Gly Cys Val Ala Met Lys Thr Gly Val Ala 
        595                 600                 605             


Gly Gly Leu Trp Asp Val Leu Ser Cys Glu Glu Lys Ala Lys Phe Val 
    610                 615                 620                 


Cys Lys His Trp Ala Glu Gly Val Thr Arg Pro Pro Glu Pro Thr Thr 
625                 630                 635                 640 


Thr Pro Glu Pro Lys Cys Pro Glu Asn Trp Gly Thr Thr Ser Lys Thr 
                645                 650                 655     


Ser Met Cys Phe Lys Leu Tyr Ala Lys Gly Lys His Glu Lys Lys Thr 
            660                 665                 670         


Trp Phe Glu Ser Arg Asp Phe Cys Lys Ala Ile Gly Gly Glu Leu Ala 
        675                 680                 685             


Ser Ile Lys Ser Lys Asp Glu Gln Gln Val Ile Trp Arg Leu Ile Thr 
    690                 695                 700                 


Ser Ser Gly Ser Tyr His Glu Leu Phe Trp Leu Gly Leu Thr Tyr Gly 
705                 710                 715                 720 


Ser Pro Ser Glu Gly Phe Thr Trp Ser Asp Gly Ser Pro Val Ser Tyr 
                725                 730                 735     


Glu Asn Trp Ala Tyr Gly Glu Pro Asn Asn Tyr Gln Asn Val Glu Tyr 
            740                 745                 750         


Cys Gly Glu Leu Lys Gly Asp Pro Gly Met Ser Trp Asn Asp Ile Asn 
        755                 760                 765             


Cys Glu His Leu Asn Asn Trp Ile Cys Gln Ile Gln Lys Gly Lys Thr 
    770                 775                 780                 


Leu Leu Pro Glu Pro Thr Pro Ala Pro Gln Asp Asn Pro Pro Val Thr 
785                 790                 795                 800 


Ala Asp Gly Trp Val Ile Tyr Lys Asp Tyr Gln Tyr Tyr Phe Ser Lys 
                805                 810                 815     


Glu Lys Glu Thr Met Asp Asn Ala Arg Ala Phe Cys Lys Lys Asn Phe 
            820                 825                 830         


Gly Asp Leu Ala Thr Ile Lys Ser Glu Ser Glu Lys Lys Phe Leu Trp 
        835                 840                 845             


Lys Tyr Ile Asn Lys Asn Gly Gly Gln Ser Pro Tyr Phe Ile Gly Met 
    850                 855                 860                 


Leu Ile Ser Met Asp Lys Lys Phe Ile Trp Met Asp Gly Ser Lys Val 
865                 870                 875                 880 


Asp Phe Val Ala Trp Ala Thr Gly Glu Pro Asn Phe Ala Asn Asp Asp 
                885                 890                 895     


Glu Asn Cys Val Thr Met Tyr Thr Asn Ser Gly Phe Trp Asn Asp Ile 
            900                 905                 910         


Asn Cys Gly Tyr Pro Asn Asn Phe Ile Cys Gln Arg His Asn Ser Ser 
        915                 920                 925             


Ile Asn Ala Thr Ala Met Pro Thr Thr Pro Thr Thr Pro Gly Gly Cys 
    930                 935                 940                 


Lys Glu Gly Trp His Leu Tyr Lys Asn Lys Cys Phe Lys Ile Phe Gly 
945                 950                 955                 960 


Phe Ala Asn Glu Glu Lys Lys Ser Trp Gln Asp Ala Arg Gln Ala Cys 
                965                 970                 975     


Lys Gly Leu Lys Gly Asn Leu Val Ser Ile Glu Asn Ala Gln Glu Gln 
            980                 985                 990         


Ala Phe Val Thr Tyr His Met Arg  Asp Ser Thr Phe Asn  Ala Trp Thr 
        995                 1000                 1005             


Gly Leu  Asn Asp Ile Asn Ala  Glu His Met Phe Leu  Trp Thr Ala 
    1010                 1015                 1020             


Gly Gln  Gly Val His Tyr Thr  Asn Trp Gly Lys Gly  Tyr Pro Gly 
    1025                 1030                 1035             


Gly Arg  Arg Ser Ser Leu Ser  Tyr Glu Asp Ala Asp  Cys Val Val 
    1040                 1045                 1050             


Val Ile  Gly Gly Asn Ser Arg  Glu Ala Gly Thr Trp  Met Asp Asp 
    1055                 1060                 1065             


Thr Cys  Asp Ser Lys Gln Gly  Tyr Ile Cys Gln Thr  Gln Thr Asp 
    1070                 1075                 1080             


Pro Ser  Leu Pro Val Ser Pro  Thr Thr Thr Pro Lys  Asp Gly Phe 
    1085                 1090                 1095             


Val Thr  Tyr Gly Lys Ser Ser  Tyr Ser Leu Met Lys  Leu Lys Leu 
    1100                 1105                 1110             


Pro Trp  His Glu Ala Glu Thr  Tyr Cys Lys Asp His  Thr Ser Leu 
    1115                 1120                 1125             


Leu Ala  Ser Ile Leu Asp Pro  Tyr Ser Asn Ala Phe  Ala Trp Met 
    1130                 1135                 1140             


Lys Met  His Pro Phe Asn Val  Pro Ile Trp Ile Ala  Leu Asn Ser 
    1145                 1150                 1155             


Asn Leu  Thr Asn Asn Glu Tyr  Thr Trp Thr Asp Arg  Trp Arg Val 
    1160                 1165                 1170             


Arg Tyr  Thr Asn Trp Gly Ala  Asp Glu Pro Lys Leu  Lys Ser Ala 
    1175                 1180                 1185             


Cys Val  Tyr Met Asp Val Asp  Gly Tyr Trp Arg Thr  Ser Tyr Cys 
    1190                 1195                 1200             


Asn Glu  Ser Phe Tyr Phe Leu  Cys Lys Lys Ser Asp  Glu Ile Pro 
    1205                 1210                 1215             


Ala Thr  Glu Pro Pro Gln Leu  Pro Gly Lys Cys Pro  Glu Ser Glu 
    1220                 1225                 1230             


Gln Thr  Ala Trp Ile Pro Phe  Tyr Gly His Cys Tyr  Tyr Phe Glu 
    1235                 1240                 1245             


Ser Ser  Phe Thr Arg Ser Trp  Gly Gln Ala Ser Leu  Glu Cys Leu 
    1250                 1255                 1260             


Arg Met  Gly Ala Ser Leu Val  Ser Ile Glu Thr Ala  Ala Glu Ser 
    1265                 1270                 1275             


Ser Phe  Leu Ser Tyr Arg Val  Glu Pro Leu Lys Ser  Lys Thr Asn 
    1280                 1285                 1290             


Phe Trp  Ile Gly Met Phe Arg  Asn Val Glu Gly Lys  Trp Leu Trp 
    1295                 1300                 1305             


Leu Asn  Asp Asn Pro Val Ser  Phe Val Asn Trp Lys  Thr Gly Asp 
    1310                 1315                 1320             


Pro Ser  Gly Glu Arg Asn Asp  Cys Val Val Leu Ala  Ser Ser Ser 
    1325                 1330                 1335             


Gly Leu  Trp Asn Asn Ile His  Cys Ser Ser Tyr Lys  Gly Phe Ile 
    1340                 1345                 1350             


Cys Lys  Met Pro Lys Ile Ile  Asp Pro Val Thr Thr  His Ser Ser 
    1355                 1360                 1365             


Ile Thr  Thr Lys Ala Asp Gln  Arg Lys Met Asp Pro  Gln Pro Lys 
    1370                 1375                 1380             


Gly Ser  Ser Lys Ala Ala Gly  Val Val Thr Val Val  Leu Leu Ile 
    1385                 1390                 1395             


Val Ile  Gly Ala Gly Val Ala  Ala Tyr Phe Phe Tyr  Lys Lys Arg 
    1400                 1405                 1410             


His Ala  Leu His Ile Pro Gln  Glu Ala Thr Phe Glu  Asn Thr Leu 
    1415                 1420                 1425             


Tyr Phe  Asn Ser Asn Leu Ser  Pro Gly Thr Ser Asp  Thr Lys Asp 
    1430                 1435                 1440             


Leu Met  Gly Asn Ile Glu Gln  Asn Glu His Ala Ile  Ile 
    1445                 1450                 1455     


<210>  702
<211>  1159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CD163

<400>  702

Met Gly Gly His Arg Met Val Leu Leu Gly Gly Ala Gly Ser Pro Gly 
1               5                   10                  15      


Cys Lys Arg Phe Val His Leu Gly Phe Phe Val Val Ala Val Ser Ser 
            20                  25                  30          


Leu Leu Ser Ala Ser Ala Val Thr Asn Ala Pro Gly Glu Met Lys Lys 
        35                  40                  45              


Glu Leu Arg Leu Ala Gly Gly Glu Asn Asn Cys Ser Gly Arg Val Glu 
    50                  55                  60                  


Leu Lys Ile His Asp Lys Trp Gly Thr Val Cys Ser Asn Gly Trp Ser 
65                  70                  75                  80  


Met Asn Glu Val Ser Val Val Cys Gln Gln Leu Gly Cys Pro Thr Ser 
                85                  90                  95      


Ile Lys Ala Leu Gly Trp Ala Asn Ser Ser Ala Gly Ser Gly Tyr Ile 
            100                 105                 110         


Trp Met Asp Lys Val Ser Cys Thr Gly Asn Glu Ser Ala Leu Trp Asp 
        115                 120                 125             


Cys Lys His Asp Gly Trp Gly Lys His Asn Cys Thr His Glu Lys Asp 
    130                 135                 140                 


Ala Gly Val Thr Cys Ser Asp Gly Ser Asn Leu Glu Met Arg Leu Val 
145                 150                 155                 160 


Asn Ser Ala Gly His Arg Cys Leu Gly Arg Val Glu Ile Lys Phe Gln 
                165                 170                 175     


Gly Lys Trp Gly Thr Val Cys Asp Asp Asn Phe Ser Lys Asp His Ala 
            180                 185                 190         


Ser Val Ile Cys Lys Gln Leu Gly Cys Gly Ser Ala Ile Ser Phe Ser 
        195                 200                 205             


Gly Ser Ala Lys Leu Gly Ala Gly Ser Gly Pro Ile Trp Leu Asp Asp 
    210                 215                 220                 


Leu Ala Cys Asn Gly Asn Glu Ser Ala Leu Trp Asp Cys Lys His Arg 
225                 230                 235                 240 


Gly Trp Gly Lys His Asn Cys Asp His Ala Glu Asp Val Gly Val Ile 
                245                 250                 255     


Cys Leu Glu Gly Ala Asp Leu Ser Leu Arg Leu Val Asp Gly Val Ser 
            260                 265                 270         


Arg Cys Ser Gly Arg Leu Glu Val Arg Phe Gln Gly Glu Trp Gly Thr 
        275                 280                 285             


Val Cys Asp Asp Asn Trp Asp Leu Arg Asp Ala Ser Val Val Cys Lys 
    290                 295                 300                 


Gln Leu Gly Cys Pro Thr Ala Ile Ser Ala Ile Gly Arg Val Asn Ala 
305                 310                 315                 320 


Ser Glu Gly Ser Gly Gln Ile Trp Leu Asp Asn Ile Ser Cys Glu Gly 
                325                 330                 335     


His Glu Ala Thr Leu Trp Glu Cys Lys His Gln Glu Trp Gly Lys His 
            340                 345                 350         


Tyr Cys His His Arg Glu Asp Ala Gly Val Thr Cys Ser Asp Gly Ala 
        355                 360                 365             


Asp Leu Glu Leu Arg Leu Val Gly Gly Gly Ser Arg Cys Ala Gly Ile 
    370                 375                 380                 


Val Glu Val Glu Ile Gln Lys Leu Thr Gly Lys Met Cys Ser Arg Gly 
385                 390                 395                 400 


Trp Thr Leu Ala Asp Ala Asp Val Val Cys Arg Gln Leu Gly Cys Gly 
                405                 410                 415     


Ser Ala Leu Gln Thr Gln Ala Lys Ile Tyr Ser Lys Thr Gly Ala Thr 
            420                 425                 430         


Asn Thr Trp Leu Phe Pro Gly Ser Cys Asn Gly Asn Glu Thr Thr Phe 
        435                 440                 445             


Trp Gln Cys Lys Asn Trp Gln Trp Gly Gly Leu Ser Cys Asp Asn Phe 
    450                 455                 460                 


Glu Glu Ala Lys Val Thr Cys Ser Gly His Arg Glu Pro Arg Leu Val 
465                 470                 475                 480 


Gly Gly Glu Ile Pro Cys Ser Gly Arg Val Glu Val Lys His Gly Asp 
                485                 490                 495     


Val Trp Gly Ser Val Cys Asp Phe Asp Leu Ser Leu Glu Ala Ala Ser 
            500                 505                 510         


Val Val Cys Arg Glu Leu Gln Cys Gly Thr Val Val Ser Ile Leu Gly 
        515                 520                 525             


Gly Ala His Phe Gly Glu Gly Ser Gly Gln Ile Trp Gly Glu Glu Phe 
    530                 535                 540                 


Gln Cys Ser Gly Asp Glu Ser His Leu Ser Leu Cys Ser Val Ala Pro 
545                 550                 555                 560 


Pro Leu Asp Arg Thr Cys Thr His Ser Arg Asp Val Ser Val Val Cys 
                565                 570                 575     


Ser Arg Tyr Ile Asp Ile Arg Leu Ala Gly Gly Glu Ser Ser Cys Glu 
            580                 585                 590         


Gly Arg Val Glu Leu Lys Thr Leu Gly Ala Trp Gly Pro Leu Cys Ser 
        595                 600                 605             


Ser His Trp Asp Met Glu Asp Ala His Val Leu Cys Gln Gln Leu Lys 
    610                 615                 620                 


Cys Gly Val Ala Gln Ser Ile Pro Glu Gly Ala His Phe Gly Lys Gly 
625                 630                 635                 640 


Ala Gly Gln Val Trp Ser His Met Phe His Cys Thr Gly Thr Glu Glu 
                645                 650                 655     


His Ile Gly Asp Cys Leu Met Thr Ala Leu Gly Ala Pro Thr Cys Ser 
            660                 665                 670         


Glu Gly Gln Val Ala Ser Val Ile Cys Ser Gly Asn Gln Ser Gln Thr 
        675                 680                 685             


Leu Leu Pro Cys Ser Ser Leu Ser Pro Val Gln Thr Thr Ser Ser Thr 
    690                 695                 700                 


Ile Pro Lys Glu Ser Glu Val Pro Cys Ile Ala Ser Gly Gln Leu Arg 
705                 710                 715                 720 


Leu Val Gly Gly Gly Gly Arg Cys Ala Gly Arg Val Glu Val Tyr His 
                725                 730                 735     


Glu Gly Ser Trp Gly Thr Val Cys Asp Asp Asn Trp Asp Met Thr Asp 
            740                 745                 750         


Ala Asn Val Val Cys Lys Gln Leu Asp Cys Gly Val Ala Ile Asn Ala 
        755                 760                 765             


Thr Gly Ser Ala Tyr Phe Gly Glu Gly Ala Gly Ala Ile Trp Leu Asp 
    770                 775                 780                 


Glu Val Ile Cys Thr Gly Lys Glu Ser His Ile Trp Gln Cys His Ser 
785                 790                 795                 800 


His Gly Trp Gly Arg His Asn Cys Arg His Lys Glu Asp Ala Gly Val 
                805                 810                 815     


Ile Cys Ser Glu Phe Met Ser Leu Arg Leu Thr Asn Glu Ala His Lys 
            820                 825                 830         


Glu Asn Cys Thr Gly Arg Leu Glu Val Phe Tyr Asn Gly Thr Trp Gly 
        835                 840                 845             


Ser Ile Gly Ser Ser Asn Met Ser Pro Thr Thr Val Gly Val Val Cys 
    850                 855                 860                 


Arg Gln Leu Gly Cys Ala Asp Asn Gly Thr Val Lys Pro Ile Pro Ser 
865                 870                 875                 880 


Asp Lys Thr Pro Ser Arg Pro Met Trp Val Asp Arg Val Gln Cys Pro 
                885                 890                 895     


Lys Gly Val Asp Thr Leu Trp Gln Cys Pro Ser Ser Pro Trp Lys Gln 
            900                 905                 910         


Arg Gln Ala Ser Pro Ser Ser Gln Glu Ser Trp Ile Ile Cys Asp Asn 
        915                 920                 925             


Lys Ile Arg Leu Gln Glu Gly His Thr Asp Cys Ser Gly Arg Val Glu 
    930                 935                 940                 


Ile Trp His Lys Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp 
945                 950                 955                 960 


Leu Asn Asp Ala Lys Val Val Cys Lys Gln Leu Gly Cys Gly Gln Ala 
                965                 970                 975     


Val Lys Ala Leu Lys Glu Ala Ala Phe Gly Pro Gly Thr Gly Pro Ile 
            980                 985                 990         


Trp Leu Asn Glu Ile Lys Cys Arg  Gly Asn Glu Ser Ser  Leu Trp Asp 
        995                 1000                 1005             


Cys Pro  Ala Lys Pro Trp Ser  His Ser Asp Cys Gly  His Lys Glu 
    1010                 1015                 1020             


Asp Ala  Ser Ile Gln Cys Leu  Pro Lys Met Thr Ser  Glu Ser His 
    1025                 1030                 1035             


His Gly  Thr Gly His Pro Thr  Leu Thr Ala Leu Leu  Val Cys Gly 
    1040                 1045                 1050             


Ala Ile  Leu Leu Val Leu Leu  Ile Val Phe Leu Leu  Trp Thr Leu 
    1055                 1060                 1065             


Lys Arg  Arg Gln Ile Gln Arg  Leu Thr Val Ser Ser  Arg Gly Glu 
    1070                 1075                 1080             


Val Leu  Ile His Gln Val Gln  Tyr Gln Glu Met Asp  Ser Lys Ala 
    1085                 1090                 1095             


Asp Asp  Leu Asp Leu Leu Lys  Ser Ser Glu Asn Ser  Asn Asn Ser 
    1100                 1105                 1110             


Tyr Asp  Phe Asn Asp Asp Gly  Leu Thr Ser Leu Ser  Lys Tyr Leu 
    1115                 1120                 1125             


Pro Ile  Ser Gly Ile Lys Lys  Gly Ser Phe Arg Gly  Thr Leu Arg 
    1130                 1135                 1140             


Arg Lys  Met Ile Ile Tyr Asn  Pro Leu Arg Leu Glu  Phe Lys Lys 
    1145                 1150                 1155             


Pro 
    


<210>  703
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Fn14

<400>  703

Met Ala Ser Ala Trp Pro Arg Ser Leu Pro Gln Ile Leu Val Leu Gly 
1               5                   10                  15      


Phe Gly Leu Val Leu Met Arg Ala Ala Ala Gly Glu Gln Ala Pro Gly 
            20                  25                  30          


Thr Ser Pro Cys Ser Ser Gly Ser Ser Trp Ser Ala Asp Leu Asp Lys 
        35                  40                  45              


Cys Met Asp Cys Ala Ser Cys Pro Ala Arg Pro His Ser Asp Phe Cys 
    50                  55                  60                  


Leu Gly Cys Ala Ala Ala Pro Pro Ala His Phe Arg Leu Leu Trp Pro 
65                  70                  75                  80  


Ile Leu Gly Gly Ala Leu Ser Leu Val Leu Val Leu Ala Leu Val Ser 
                85                  90                  95      


Ser Phe Leu Val Trp Arg Arg Cys Arg Arg Arg Glu Lys Phe Thr Thr 
            100                 105                 110         


Pro Ile Glu Glu Thr Gly Gly Glu Gly Cys Pro Gly Val Ala Leu Ile 
        115                 120                 125             


Gln 
    

<210> 704

<400> 704
000

<210> 705

<400> 705
000

<210> 706

<400> 706
000

<210> 707

<400> 707
000

<210> 708

<400> 708
000

<210> 709

<400> 709
000

<210> 710

<400> 710
000

<210> 711

<400> 711
000

<210> 712

<400> 712
000

<210> 713

<400> 713
000

<210> 714

<400> 714
000

<210> 715

<400> 715
000

<210> 716

<400> 716
000

<210> 717

<400> 717
000

<210> 718

<400> 718
000

<210> 719

<400> 719
000

<210> 720

<400> 720
000

<210> 721

<400> 721
000

<210> 722

<400> 722
000

<210> 723

<400> 723
000

<210> 724

<400> 724
000

<210> 725

<400> 725
000

<210> 726

<400> 726
000

<210> 727

<400> 727
000

<210> 728

<400> 728
000

<210> 729

<400> 729
000

<210> 730

<400> 730
000

<210> 731

<400> 731
000

<210> 732

<400> 732
000

<210> 733

<400> 733
000

<210> 734

<400> 734
000

<210> 735

<400> 735
000

<210> 736

<400> 736
000

<210> 737

<400> 737
000

<210> 738

<400> 738
000

<210> 739

<400> 739
000

<210> 740

<400> 740
000

<210> 741

<400> 741
000

<210> 742

<400> 742
000

<210> 743

<400> 743
000

<210> 744

<400> 744
000


<210>  745
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CD28 hinge (mCD28H)

<400>  745

Ile Lys Glu Lys His Leu Cys His Thr Gln Ser Ser Pro Lys Leu 
1               5                   10                  15  


<210>  746
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CD28 transmembrane domain (mCD28TM)

<400>  746

Phe Trp Ala Leu Val Val Val Ala Gly Val Leu Phe Cys Tyr Gly Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Leu Cys Val Ile Trp Thr 
            20                  25          


<210>  747
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CD3 zeta intracellular signaling domain (mCD3zICS)

<400>  747

Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp 
1               5                   10                  15      


Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro 
            100                 105                 110         


Arg 
    

<210> 748

<400> 748
000

<210> 749

<400> 749
000

<210> 750

<400> 750
000


<210>  751
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse truncated CD19 (mtrCD19)

<400>  751

Met Pro Ser Pro Leu Pro Val Ser Phe Leu Leu Phe Leu Thr Leu Val 
1               5                   10                  15      


Gly Gly Arg Pro Gln Lys Ser Leu Leu Val Glu Val Glu Glu Gly Gly 
            20                  25                  30          


Asn Val Val Leu Pro Cys Leu Pro Asp Ser Ser Pro Val Ser Ser Glu 
        35                  40                  45              


Lys Leu Ala Trp Tyr Arg Gly Asn Gln Ser Thr Pro Phe Leu Glu Leu 
    50                  55                  60                  


Ser Pro Gly Ser Pro Gly Leu Gly Leu His Val Gly Ser Leu Gly Ile 
65                  70                  75                  80  


Leu Leu Val Ile Val Asn Val Ser Asp His Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Lys Arg Pro Pro Phe Lys Asp Ile Trp Gln Pro Ala Trp Thr 
            100                 105                 110         


Val Asn Val Glu Asp Ser Gly Glu Met Phe Arg Trp Asn Ala Ser Asp 
        115                 120                 125             


Val Arg Asp Leu Asp Cys Asp Leu Arg Asn Arg Ser Ser Gly Ser His 
    130                 135                 140                 


Arg Ser Thr Ser Gly Ser Gln Leu Tyr Val Trp Ala Lys Asp His Pro 
145                 150                 155                 160 


Lys Val Trp Gly Thr Lys Pro Val Cys Ala Pro Arg Gly Ser Ser Leu 
                165                 170                 175     


Asn Gln Ser Leu Ile Asn Gln Asp Leu Thr Val Ala Pro Gly Ser Thr 
            180                 185                 190         


Leu Trp Leu Ser Cys Gly Val Pro Pro Val Pro Val Ala Lys Gly Ser 
        195                 200                 205             


Ile Ser Trp Thr His Val His Pro Arg Arg Pro Asn Val Ser Leu Leu 
    210                 215                 220                 


Ser Leu Ser Leu Gly Gly Glu His Pro Val Arg Glu Met Trp Val Trp 
225                 230                 235                 240 


Gly Ser Leu Leu Leu Leu Pro Gln Ala Thr Ala Leu Asp Glu Gly Thr 
                245                 250                 255     


Tyr Tyr Cys Leu Arg Gly Asn Leu Thr Ile Glu Arg His Val Lys Val 
            260                 265                 270         


Ile Ala Arg Ser Ala Val Trp Leu Trp Leu Leu Arg Thr Gly Gly Trp 
        275                 280                 285             


Ile Val Pro Val Val Thr Leu Val Tyr Val Ile Phe Cys Met Val Ser 
    290                 295                 300                 


Leu Val Ala Phe Leu Tyr Cys Gln Arg Ala Phe Ile Leu Arg Arg Lys 
305                 310                 315                 320 


Arg Lys Arg Met Thr 
                325 



<210> 752

<400> 752
000

<210> 753

<400> 753
000

<210> 754

<400> 754
000

<210> 755

<400> 755
000


<210>  756
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CD28 costimulatory domain (mCD28CS)

<400>  756

Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Ala Arg Asp Phe Ala Ala Tyr Arg Pro 
        35                  40      



<210> 757

<400> 757
000

<210> 758

<400> 758
000

<210> 759

<400> 759
000


<210>  760
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NbMMRm22.84-mCD28H-mCD28TM-mCD28CS-mCD3zICS

<400>  760

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Asn Tyr Ala Met Gly Trp Phe Arg Gln Phe Pro Gly Lys Glu Arg 
        35                  40                  45              


Glu Phe Val Ala Ser Ile Ser Trp Ser Ser Val Thr Thr Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala His Leu Ala Gln Tyr Ser Asp Tyr Ala Tyr Arg 
            100                 105                 110         


Asp Pro His Gln Phe Gly Ala Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser Ile Lys Glu Lys His Leu Cys His Thr Gln Ser Ser Pro Lys 
    130                 135                 140                 


Leu Phe Trp Ala Leu Val Val Val Ala Gly Val Leu Phe Cys Tyr Gly 
145                 150                 155                 160 


Leu Leu Val Thr Val Ala Leu Cys Val Ile Trp Thr Asn Ser Arg Arg 
                165                 170                 175     


Asn Arg Leu Leu Gln Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            180                 185                 190         


Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe 
        195                 200                 205             


Ala Ala Tyr Arg Pro Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala 
    210                 215                 220                 


Ala Asn Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
225                 230                 235                 240 


Arg Arg Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro 
                245                 250                 255     


Glu Met Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val 
            260                 265                 270         


Tyr Asn Ala Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        275                 280                 285             


Gly Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    290                 295                 300                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
305                 310                 315                 320 


Gln Thr Leu Ala Pro Arg 
                325     


<210>  761
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NbMMRm5.38-mCD28H-mCD28TM-mCD28CS-mCD3zICS

<400>  761

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asp Asp Asp Tyr 
            20                  25                  30          


Asp Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Phe Phe Arg Trp Asp Ser Gly Ser Tyr Tyr Val Arg Gly 
            100                 105                 110         


Cys Arg His Ala Thr Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser Ile Lys Glu Lys His Leu Cys His Thr Gln Ser Ser Pro 
    130                 135                 140                 


Lys Leu Phe Trp Ala Leu Val Val Val Ala Gly Val Leu Phe Cys Tyr 
145                 150                 155                 160 


Gly Leu Leu Val Thr Val Ala Leu Cys Val Ile Trp Thr Asn Ser Arg 
                165                 170                 175     


Arg Asn Arg Leu Leu Gln Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            180                 185                 190         


Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala Pro Ala Arg Asp 
        195                 200                 205             


Phe Ala Ala Tyr Arg Pro Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr 
    210                 215                 220                 


Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
225                 230                 235                 240 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg Asp 
                245                 250                 255     


Pro Glu Met Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly 
            260                 265                 270         


Val Tyr Asn Ala Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        275                 280                 285             


Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    290                 295                 300                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
305                 310                 315                 320 


Met Gln Thr Leu Ala Pro Arg 
                325         


<210>  762
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFvP4A8VHVL-mCD28H-mCD28TM-mCD28CS-mCD3zICS

<400>  762

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Ile Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys Ile Lys Glu Lys His Leu Cys His Thr 
                245                 250                 255     


Gln Ser Ser Pro Lys Leu Phe Trp Ala Leu Val Val Val Ala Gly Val 
            260                 265                 270         


Leu Phe Cys Tyr Gly Leu Leu Val Thr Val Ala Leu Cys Val Ile Trp 
        275                 280                 285             


Thr Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser Asp Tyr Met Asn Met 
    290                 295                 300                 


Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala 
305                 310                 315                 320 


Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro Arg Ala Lys Phe Ser Arg 
                325                 330                 335     


Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu Tyr Asn 
            340                 345                 350         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Glu Lys Lys 
        355                 360                 365             


Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg Arg Arg Asn 
    370                 375                 380                 


Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys Met Ala Glu 
385                 390                 395                 400 


Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                405                 410                 415     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            420                 425                 430         


Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg 
        435                 440             


<210>  763
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFvP4A8VLVH-mCD28H-mCD28TM-mCD28CS-mCD3zICS

<400>  763

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        115                 120                 125             


Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val Ser Val 
    130                 135                 140                 


Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr Gly Met 
145                 150                 155                 160 


His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile Gly Val 
                165                 170                 175     


Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Gly 
            180                 185                 190         


Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
        195                 200                 205             


Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser Ile Lys Glu Lys His Leu Cys His Thr 
                245                 250                 255     


Gln Ser Ser Pro Lys Leu Phe Trp Ala Leu Val Val Val Ala Gly Val 
            260                 265                 270         


Leu Phe Cys Tyr Gly Leu Leu Val Thr Val Ala Leu Cys Val Ile Trp 
        275                 280                 285             


Thr Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser Asp Tyr Met Asn Met 
    290                 295                 300                 


Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala 
305                 310                 315                 320 


Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro Arg Ala Lys Phe Ser Arg 
                325                 330                 335     


Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu Tyr Asn 
            340                 345                 350         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Glu Lys Lys 
        355                 360                 365             


Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg Arg Arg Asn 
    370                 375                 380                 


Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys Met Ala Glu 
385                 390                 395                 400 


Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                405                 410                 415     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            420                 425                 430         


Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg 
        435                 440             


<210>  764
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFvP3G5VHVL-mCD28H-mCD28TM-mCD28CS-mCD3zICS

<400>  764

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Ile His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg 
145                 150                 155                 160 


Ala Asn Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Ile Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys Ile Lys Glu Lys His Leu Cys His Thr 
                245                 250                 255     


Gln Ser Ser Pro Lys Leu Phe Trp Ala Leu Val Val Val Ala Gly Val 
            260                 265                 270         


Leu Phe Cys Tyr Gly Leu Leu Val Thr Val Ala Leu Cys Val Ile Trp 
        275                 280                 285             


Thr Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser Asp Tyr Met Asn Met 
    290                 295                 300                 


Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala 
305                 310                 315                 320 


Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro Arg Ala Lys Phe Ser Arg 
                325                 330                 335     


Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu Tyr Asn 
            340                 345                 350         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Glu Lys Lys 
        355                 360                 365             


Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg Arg Arg Asn 
    370                 375                 380                 


Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys Met Ala Glu 
385                 390                 395                 400 


Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                405                 410                 415     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            420                 425                 430         


Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg 
        435                 440             


<210>  765
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFvP3G5VLVH-mCD28H-mCD28TM-mCD28CS-mCD3zICS

<400>  765

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Asn Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        115                 120                 125             


Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val Ser Val 
    130                 135                 140                 


Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr Gly Ile 
145                 150                 155                 160 


His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile Gly Val 
                165                 170                 175     


Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Gly 
            180                 185                 190         


Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
        195                 200                 205             


Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser Ile Lys Glu Lys His Leu Cys His Thr 
                245                 250                 255     


Gln Ser Ser Pro Lys Leu Phe Trp Ala Leu Val Val Val Ala Gly Val 
            260                 265                 270         


Leu Phe Cys Tyr Gly Leu Leu Val Thr Val Ala Leu Cys Val Ile Trp 
        275                 280                 285             


Thr Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser Asp Tyr Met Asn Met 
    290                 295                 300                 


Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala 
305                 310                 315                 320 


Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro Arg Ala Lys Phe Ser Arg 
                325                 330                 335     


Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu Tyr Asn 
            340                 345                 350         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Glu Lys Lys 
        355                 360                 365             


Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg Arg Arg Asn 
    370                 375                 380                 


Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys Met Ala Glu 
385                 390                 395                 400 


Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                405                 410                 415     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            420                 425                 430         


Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg 
        435                 440             


<210>  766
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mCD3zICS-mCD28CS-mTWEAK

<400>  766

Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp 
1               5                   10                  15      


Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro 
            100                 105                 110         


Arg Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser Asp Tyr Met Asn Met 
        115                 120                 125             


Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala 
    130                 135                 140                 


Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro Ala Ala Arg Arg Ser Gln 
145                 150                 155                 160 


Arg Arg Arg Gly Arg Arg Gly Glu Pro Gly Thr Ala Leu Leu Ala Pro 
                165                 170                 175     


Leu Val Leu Ser Leu Gly Leu Ala Leu Ala Cys Leu Gly Leu Leu Leu 
            180                 185                 190         


Val Val Val Ser Leu Gly Ser Trp Ala Thr Leu Ser Ala Gln Glu Pro 
        195                 200                 205             


Ser Gln Glu Glu Leu Thr Ala Glu Asp Arg Arg Glu Pro Pro Glu Leu 
    210                 215                 220                 


Asn Pro Gln Thr Glu Glu Ser Gln Asp Val Val Pro Phe Leu Glu Gln 
225                 230                 235                 240 


Leu Val Arg Pro Arg Arg Ser Ala Pro Lys Gly Arg Lys Ala Arg Pro 
                245                 250                 255     


Arg Arg Ala Ile Ala Ala His Tyr Glu Val His Pro Arg Pro Gly Gln 
            260                 265                 270         


Asp Gly Ala Gln Ala Gly Val Asp Gly Thr Val Ser Gly Trp Glu Glu 
        275                 280                 285             


Thr Lys Ile Asn Ser Ser Ser Pro Leu Arg Tyr Asp Arg Gln Ile Gly 
    290                 295                 300                 


Glu Phe Thr Val Ile Arg Ala Gly Leu Tyr Tyr Leu Tyr Cys Gln Val 
305                 310                 315                 320 


His Phe Asp Glu Gly Lys Ala Val Tyr Leu Lys Leu Asp Leu Leu Val 
                325                 330                 335     


Asn Gly Val Leu Ala Leu Arg Cys Leu Glu Glu Phe Ser Ala Thr Ala 
            340                 345                 350         


Ala Ser Ser Pro Gly Pro Gln Leu Arg Leu Cys Gln Val Ser Gly Leu 
        355                 360                 365             


Leu Pro Leu Arg Pro Gly Ser Ser Leu Arg Ile Arg Thr Leu Pro Trp 
    370                 375                 380                 


Ala His Leu Lys Ala Ala Pro Phe Leu Thr Tyr Phe Gly Leu Phe Gln 
385                 390                 395                 400 


Val His 
        


<210> 767

<400> 767
000

<210> 768

<400> 768
000

<210> 769

<400> 769
000

<210> 770

<400> 770
000

<210> 771

<400> 771
000

<210> 772

<400> 772
000

<210> 773

<400> 773
000

<210> 774

<400> 774
000

<210> 775

<400> 775
000

<210> 776

<400> 776
000

<210> 777

<400> 777
000


<210>  778
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm22.84-mCD28H-mCD28TM-mCD28CS-mCD3zICS-T2A-mtrCD19

<400>  778

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
        35                  40                  45              


Ser Asn Tyr Val Asn Tyr Ala Met Gly Trp Phe Arg Gln Phe Pro Gly 
    50                  55                  60                  


Lys Glu Arg Glu Phe Val Ala Ser Ile Ser Trp Ser Ser Val Thr Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Ala His Leu Ala Gln Tyr Ser Asp Tyr 
        115                 120                 125             


Ala Tyr Arg Asp Pro His Gln Phe Gly Ala Trp Gly Gln Gly Thr Gln 
    130                 135                 140                 


Val Thr Val Ser Ser Ile Lys Glu Lys His Leu Cys His Thr Gln Ser 
145                 150                 155                 160 


Ser Pro Lys Leu Phe Trp Ala Leu Val Val Val Ala Gly Val Leu Phe 
                165                 170                 175     


Cys Tyr Gly Leu Leu Val Thr Val Ala Leu Cys Val Ile Trp Thr Asn 
            180                 185                 190         


Ser Arg Arg Asn Arg Leu Leu Gln Ser Asp Tyr Met Asn Met Thr Pro 
        195                 200                 205             


Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala Pro Ala 
    210                 215                 220                 


Arg Asp Phe Ala Ala Tyr Arg Pro Arg Ala Lys Phe Ser Arg Ser Ala 
225                 230                 235                 240 


Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu Leu 
                245                 250                 255     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg Ala 
            260                 265                 270         


Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln 
        275                 280                 285             


Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    290                 295                 300                 


Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
305                 310                 315                 320 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                325                 330                 335     


Leu His Met Gln Thr Leu Ala Pro Arg Ala Arg Ala Lys Arg Ser Gly 
            340                 345                 350         


Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
        355                 360                 365             


Asn Pro Gly Pro Met Pro Ser Pro Leu Pro Val Ser Phe Leu Leu Phe 
    370                 375                 380                 


Leu Thr Leu Val Gly Gly Arg Pro Gln Lys Ser Leu Leu Val Glu Val 
385                 390                 395                 400 


Glu Glu Gly Gly Asn Val Val Leu Pro Cys Leu Pro Asp Ser Ser Pro 
                405                 410                 415     


Val Ser Ser Glu Lys Leu Ala Trp Tyr Arg Gly Asn Gln Ser Thr Pro 
            420                 425                 430         


Phe Leu Glu Leu Ser Pro Gly Ser Pro Gly Leu Gly Leu His Val Gly 
        435                 440                 445             


Ser Leu Gly Ile Leu Leu Val Ile Val Asn Val Ser Asp His Met Gly 
    450                 455                 460                 


Gly Phe Tyr Leu Cys Gln Lys Arg Pro Pro Phe Lys Asp Ile Trp Gln 
465                 470                 475                 480 


Pro Ala Trp Thr Val Asn Val Glu Asp Ser Gly Glu Met Phe Arg Trp 
                485                 490                 495     


Asn Ala Ser Asp Val Arg Asp Leu Asp Cys Asp Leu Arg Asn Arg Ser 
            500                 505                 510         


Ser Gly Ser His Arg Ser Thr Ser Gly Ser Gln Leu Tyr Val Trp Ala 
        515                 520                 525             


Lys Asp His Pro Lys Val Trp Gly Thr Lys Pro Val Cys Ala Pro Arg 
    530                 535                 540                 


Gly Ser Ser Leu Asn Gln Ser Leu Ile Asn Gln Asp Leu Thr Val Ala 
545                 550                 555                 560 


Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Val Pro Val 
                565                 570                 575     


Ala Lys Gly Ser Ile Ser Trp Thr His Val His Pro Arg Arg Pro Asn 
            580                 585                 590         


Val Ser Leu Leu Ser Leu Ser Leu Gly Gly Glu His Pro Val Arg Glu 
        595                 600                 605             


Met Trp Val Trp Gly Ser Leu Leu Leu Leu Pro Gln Ala Thr Ala Leu 
    610                 615                 620                 


Asp Glu Gly Thr Tyr Tyr Cys Leu Arg Gly Asn Leu Thr Ile Glu Arg 
625                 630                 635                 640 


His Val Lys Val Ile Ala Arg Ser Ala Val Trp Leu Trp Leu Leu Arg 
                645                 650                 655     


Thr Gly Gly Trp Ile Val Pro Val Val Thr Leu Val Tyr Val Ile Phe 
            660                 665                 670         


Cys Met Val Ser Leu Val Ala Phe Leu Tyr Cys Gln Arg Ala Phe Ile 
        675                 680                 685             


Leu Arg Arg Lys Arg Lys Arg Met Thr 
    690                 695         


<210>  779
<211>  698
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm5.38-mCD28H-mCD28TM-mCD28CS-mCD3zICS-T2A-mtrCD19

<400>  779

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asp 
        35                  40                  45              


Asp Asp Tyr Asp Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    50                  55                  60                  


Glu Gly Val Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Asp Phe Phe Arg Trp Asp Ser Gly Ser Tyr Tyr 
        115                 120                 125             


Val Arg Gly Cys Arg His Ala Thr Tyr Asp Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Gln Val Thr Val Ser Ser Ile Lys Glu Lys His Leu Cys His Thr Gln 
145                 150                 155                 160 


Ser Ser Pro Lys Leu Phe Trp Ala Leu Val Val Val Ala Gly Val Leu 
                165                 170                 175     


Phe Cys Tyr Gly Leu Leu Val Thr Val Ala Leu Cys Val Ile Trp Thr 
            180                 185                 190         


Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser Asp Tyr Met Asn Met Thr 
        195                 200                 205             


Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala Pro 
    210                 215                 220                 


Ala Arg Asp Phe Ala Ala Tyr Arg Pro Arg Ala Lys Phe Ser Arg Ser 
225                 230                 235                 240 


Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu 
                245                 250                 255     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg 
            260                 265                 270         


Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro 
        275                 280                 285             


Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys Met Ala Glu Ala 
    290                 295                 300                 


Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
305                 310                 315                 320 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                325                 330                 335     


Ala Leu His Met Gln Thr Leu Ala Pro Arg Ala Arg Ala Lys Arg Ser 
            340                 345                 350         


Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
        355                 360                 365             


Glu Asn Pro Gly Pro Met Pro Ser Pro Leu Pro Val Ser Phe Leu Leu 
    370                 375                 380                 


Phe Leu Thr Leu Val Gly Gly Arg Pro Gln Lys Ser Leu Leu Val Glu 
385                 390                 395                 400 


Val Glu Glu Gly Gly Asn Val Val Leu Pro Cys Leu Pro Asp Ser Ser 
                405                 410                 415     


Pro Val Ser Ser Glu Lys Leu Ala Trp Tyr Arg Gly Asn Gln Ser Thr 
            420                 425                 430         


Pro Phe Leu Glu Leu Ser Pro Gly Ser Pro Gly Leu Gly Leu His Val 
        435                 440                 445             


Gly Ser Leu Gly Ile Leu Leu Val Ile Val Asn Val Ser Asp His Met 
    450                 455                 460                 


Gly Gly Phe Tyr Leu Cys Gln Lys Arg Pro Pro Phe Lys Asp Ile Trp 
465                 470                 475                 480 


Gln Pro Ala Trp Thr Val Asn Val Glu Asp Ser Gly Glu Met Phe Arg 
                485                 490                 495     


Trp Asn Ala Ser Asp Val Arg Asp Leu Asp Cys Asp Leu Arg Asn Arg 
            500                 505                 510         


Ser Ser Gly Ser His Arg Ser Thr Ser Gly Ser Gln Leu Tyr Val Trp 
        515                 520                 525             


Ala Lys Asp His Pro Lys Val Trp Gly Thr Lys Pro Val Cys Ala Pro 
    530                 535                 540                 


Arg Gly Ser Ser Leu Asn Gln Ser Leu Ile Asn Gln Asp Leu Thr Val 
545                 550                 555                 560 


Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Val Pro 
                565                 570                 575     


Val Ala Lys Gly Ser Ile Ser Trp Thr His Val His Pro Arg Arg Pro 
            580                 585                 590         


Asn Val Ser Leu Leu Ser Leu Ser Leu Gly Gly Glu His Pro Val Arg 
        595                 600                 605             


Glu Met Trp Val Trp Gly Ser Leu Leu Leu Leu Pro Gln Ala Thr Ala 
    610                 615                 620                 


Leu Asp Glu Gly Thr Tyr Tyr Cys Leu Arg Gly Asn Leu Thr Ile Glu 
625                 630                 635                 640 


Arg His Val Lys Val Ile Ala Arg Ser Ala Val Trp Leu Trp Leu Leu 
                645                 650                 655     


Arg Thr Gly Gly Trp Ile Val Pro Val Val Thr Leu Val Tyr Val Ile 
            660                 665                 670         


Phe Cys Met Val Ser Leu Val Ala Phe Leu Tyr Cys Gln Arg Ala Phe 
        675                 680                 685             


Ile Leu Arg Arg Lys Arg Lys Arg Met Thr 
    690                 695             


<210>  780
<211>  814
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VHVL-mCD28H-mCD28TM-mCD28CS-mCD3zICS-T2A-mtrCD19

<400>  780

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg 
            20                  25                  30          


Pro Gly Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Gly Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
                165                 170                 175     


Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys 
        195                 200                 205             


Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His Pro Val Glu Glu Glu 
225                 230                 235                 240 


Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr 
                245                 250                 255     


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Ile Lys Glu Lys His Leu 
            260                 265                 270         


Cys His Thr Gln Ser Ser Pro Lys Leu Phe Trp Ala Leu Val Val Val 
        275                 280                 285             


Ala Gly Val Leu Phe Cys Tyr Gly Leu Leu Val Thr Val Ala Leu Cys 
    290                 295                 300                 


Val Ile Trp Thr Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser Asp Tyr 
305                 310                 315                 320 


Met Asn Met Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln 
                325                 330                 335     


Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro Arg Ala Lys 
            340                 345                 350         


Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln 
        355                 360                 365             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    370                 375                 380                 


Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg 
385                 390                 395                 400 


Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys 
                405                 410                 415     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg 
            420                 425                 430         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        435                 440                 445             


Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg Ala Arg 
    450                 455                 460                 


Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
465                 470                 475                 480 


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Pro Ser Pro Leu Pro Val 
                485                 490                 495     


Ser Phe Leu Leu Phe Leu Thr Leu Val Gly Gly Arg Pro Gln Lys Ser 
            500                 505                 510         


Leu Leu Val Glu Val Glu Glu Gly Gly Asn Val Val Leu Pro Cys Leu 
        515                 520                 525             


Pro Asp Ser Ser Pro Val Ser Ser Glu Lys Leu Ala Trp Tyr Arg Gly 
    530                 535                 540                 


Asn Gln Ser Thr Pro Phe Leu Glu Leu Ser Pro Gly Ser Pro Gly Leu 
545                 550                 555                 560 


Gly Leu His Val Gly Ser Leu Gly Ile Leu Leu Val Ile Val Asn Val 
                565                 570                 575     


Ser Asp His Met Gly Gly Phe Tyr Leu Cys Gln Lys Arg Pro Pro Phe 
            580                 585                 590         


Lys Asp Ile Trp Gln Pro Ala Trp Thr Val Asn Val Glu Asp Ser Gly 
        595                 600                 605             


Glu Met Phe Arg Trp Asn Ala Ser Asp Val Arg Asp Leu Asp Cys Asp 
    610                 615                 620                 


Leu Arg Asn Arg Ser Ser Gly Ser His Arg Ser Thr Ser Gly Ser Gln 
625                 630                 635                 640 


Leu Tyr Val Trp Ala Lys Asp His Pro Lys Val Trp Gly Thr Lys Pro 
                645                 650                 655     


Val Cys Ala Pro Arg Gly Ser Ser Leu Asn Gln Ser Leu Ile Asn Gln 
            660                 665                 670         


Asp Leu Thr Val Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly Val 
        675                 680                 685             


Pro Pro Val Pro Val Ala Lys Gly Ser Ile Ser Trp Thr His Val His 
    690                 695                 700                 


Pro Arg Arg Pro Asn Val Ser Leu Leu Ser Leu Ser Leu Gly Gly Glu 
705                 710                 715                 720 


His Pro Val Arg Glu Met Trp Val Trp Gly Ser Leu Leu Leu Leu Pro 
                725                 730                 735     


Gln Ala Thr Ala Leu Asp Glu Gly Thr Tyr Tyr Cys Leu Arg Gly Asn 
            740                 745                 750         


Leu Thr Ile Glu Arg His Val Lys Val Ile Ala Arg Ser Ala Val Trp 
        755                 760                 765             


Leu Trp Leu Leu Arg Thr Gly Gly Trp Ile Val Pro Val Val Thr Leu 
    770                 775                 780                 


Val Tyr Val Ile Phe Cys Met Val Ser Leu Val Ala Phe Leu Tyr Cys 
785                 790                 795                 800 


Gln Arg Ala Phe Ile Leu Arg Arg Lys Arg Lys Arg Met Thr 
                805                 810                 


<210>  781
<211>  814
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VLVH-mCD28H-mCD28TM-mCD28CS-mCD3zICS-T2A-mtrCD19

<400>  781

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val 
        35                  40                  45              


Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly 
65                  70                  75                  80  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu 
                85                  90                  95      


Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly 
145                 150                 155                 160 


Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp 
                165                 170                 175     


Tyr Gly Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys 
        195                 200                 205             


Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ile Lys Glu Lys His Leu 
            260                 265                 270         


Cys His Thr Gln Ser Ser Pro Lys Leu Phe Trp Ala Leu Val Val Val 
        275                 280                 285             


Ala Gly Val Leu Phe Cys Tyr Gly Leu Leu Val Thr Val Ala Leu Cys 
    290                 295                 300                 


Val Ile Trp Thr Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser Asp Tyr 
305                 310                 315                 320 


Met Asn Met Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln 
                325                 330                 335     


Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro Arg Ala Lys 
            340                 345                 350         


Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln 
        355                 360                 365             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    370                 375                 380                 


Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg 
385                 390                 395                 400 


Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys 
                405                 410                 415     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg 
            420                 425                 430         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        435                 440                 445             


Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg Ala Arg 
    450                 455                 460                 


Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
465                 470                 475                 480 


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Pro Ser Pro Leu Pro Val 
                485                 490                 495     


Ser Phe Leu Leu Phe Leu Thr Leu Val Gly Gly Arg Pro Gln Lys Ser 
            500                 505                 510         


Leu Leu Val Glu Val Glu Glu Gly Gly Asn Val Val Leu Pro Cys Leu 
        515                 520                 525             


Pro Asp Ser Ser Pro Val Ser Ser Glu Lys Leu Ala Trp Tyr Arg Gly 
    530                 535                 540                 


Asn Gln Ser Thr Pro Phe Leu Glu Leu Ser Pro Gly Ser Pro Gly Leu 
545                 550                 555                 560 


Gly Leu His Val Gly Ser Leu Gly Ile Leu Leu Val Ile Val Asn Val 
                565                 570                 575     


Ser Asp His Met Gly Gly Phe Tyr Leu Cys Gln Lys Arg Pro Pro Phe 
            580                 585                 590         


Lys Asp Ile Trp Gln Pro Ala Trp Thr Val Asn Val Glu Asp Ser Gly 
        595                 600                 605             


Glu Met Phe Arg Trp Asn Ala Ser Asp Val Arg Asp Leu Asp Cys Asp 
    610                 615                 620                 


Leu Arg Asn Arg Ser Ser Gly Ser His Arg Ser Thr Ser Gly Ser Gln 
625                 630                 635                 640 


Leu Tyr Val Trp Ala Lys Asp His Pro Lys Val Trp Gly Thr Lys Pro 
                645                 650                 655     


Val Cys Ala Pro Arg Gly Ser Ser Leu Asn Gln Ser Leu Ile Asn Gln 
            660                 665                 670         


Asp Leu Thr Val Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly Val 
        675                 680                 685             


Pro Pro Val Pro Val Ala Lys Gly Ser Ile Ser Trp Thr His Val His 
    690                 695                 700                 


Pro Arg Arg Pro Asn Val Ser Leu Leu Ser Leu Ser Leu Gly Gly Glu 
705                 710                 715                 720 


His Pro Val Arg Glu Met Trp Val Trp Gly Ser Leu Leu Leu Leu Pro 
                725                 730                 735     


Gln Ala Thr Ala Leu Asp Glu Gly Thr Tyr Tyr Cys Leu Arg Gly Asn 
            740                 745                 750         


Leu Thr Ile Glu Arg His Val Lys Val Ile Ala Arg Ser Ala Val Trp 
        755                 760                 765             


Leu Trp Leu Leu Arg Thr Gly Gly Trp Ile Val Pro Val Val Thr Leu 
    770                 775                 780                 


Val Tyr Val Ile Phe Cys Met Val Ser Leu Val Ala Phe Leu Tyr Cys 
785                 790                 795                 800 


Gln Arg Ala Phe Ile Leu Arg Arg Lys Arg Lys Arg Met Thr 
                805                 810                 


<210>  782
<211>  814
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VHVL-mCD28H-mCD28TM-mCD28CS-mCD3zICS-T2A-mtrCD19

<400>  782

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg 
            20                  25                  30          


Pro Gly Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Gly Ile His Trp Val Lys Gln Ser His Ala Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
                165                 170                 175     


Ser Cys Arg Ala Asn Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys 
        195                 200                 205             


Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Ile Leu Asn Ile His Pro Val Glu Glu Glu 
225                 230                 235                 240 


Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr 
                245                 250                 255     


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Ile Lys Glu Lys His Leu 
            260                 265                 270         


Cys His Thr Gln Ser Ser Pro Lys Leu Phe Trp Ala Leu Val Val Val 
        275                 280                 285             


Ala Gly Val Leu Phe Cys Tyr Gly Leu Leu Val Thr Val Ala Leu Cys 
    290                 295                 300                 


Val Ile Trp Thr Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser Asp Tyr 
305                 310                 315                 320 


Met Asn Met Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln 
                325                 330                 335     


Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro Arg Ala Lys 
            340                 345                 350         


Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln 
        355                 360                 365             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    370                 375                 380                 


Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg 
385                 390                 395                 400 


Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys 
                405                 410                 415     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg 
            420                 425                 430         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        435                 440                 445             


Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg Ala Arg 
    450                 455                 460                 


Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
465                 470                 475                 480 


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Pro Ser Pro Leu Pro Val 
                485                 490                 495     


Ser Phe Leu Leu Phe Leu Thr Leu Val Gly Gly Arg Pro Gln Lys Ser 
            500                 505                 510         


Leu Leu Val Glu Val Glu Glu Gly Gly Asn Val Val Leu Pro Cys Leu 
        515                 520                 525             


Pro Asp Ser Ser Pro Val Ser Ser Glu Lys Leu Ala Trp Tyr Arg Gly 
    530                 535                 540                 


Asn Gln Ser Thr Pro Phe Leu Glu Leu Ser Pro Gly Ser Pro Gly Leu 
545                 550                 555                 560 


Gly Leu His Val Gly Ser Leu Gly Ile Leu Leu Val Ile Val Asn Val 
                565                 570                 575     


Ser Asp His Met Gly Gly Phe Tyr Leu Cys Gln Lys Arg Pro Pro Phe 
            580                 585                 590         


Lys Asp Ile Trp Gln Pro Ala Trp Thr Val Asn Val Glu Asp Ser Gly 
        595                 600                 605             


Glu Met Phe Arg Trp Asn Ala Ser Asp Val Arg Asp Leu Asp Cys Asp 
    610                 615                 620                 


Leu Arg Asn Arg Ser Ser Gly Ser His Arg Ser Thr Ser Gly Ser Gln 
625                 630                 635                 640 


Leu Tyr Val Trp Ala Lys Asp His Pro Lys Val Trp Gly Thr Lys Pro 
                645                 650                 655     


Val Cys Ala Pro Arg Gly Ser Ser Leu Asn Gln Ser Leu Ile Asn Gln 
            660                 665                 670         


Asp Leu Thr Val Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly Val 
        675                 680                 685             


Pro Pro Val Pro Val Ala Lys Gly Ser Ile Ser Trp Thr His Val His 
    690                 695                 700                 


Pro Arg Arg Pro Asn Val Ser Leu Leu Ser Leu Ser Leu Gly Gly Glu 
705                 710                 715                 720 


His Pro Val Arg Glu Met Trp Val Trp Gly Ser Leu Leu Leu Leu Pro 
                725                 730                 735     


Gln Ala Thr Ala Leu Asp Glu Gly Thr Tyr Tyr Cys Leu Arg Gly Asn 
            740                 745                 750         


Leu Thr Ile Glu Arg His Val Lys Val Ile Ala Arg Ser Ala Val Trp 
        755                 760                 765             


Leu Trp Leu Leu Arg Thr Gly Gly Trp Ile Val Pro Val Val Thr Leu 
    770                 775                 780                 


Val Tyr Val Ile Phe Cys Met Val Ser Leu Val Ala Phe Leu Tyr Cys 
785                 790                 795                 800 


Gln Arg Ala Phe Ile Leu Arg Arg Lys Arg Lys Arg Met Thr 
                805                 810                 


<210>  783
<211>  814
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VLVH-mCD28H-mCD28TM-mCD28CS-mCD3zICS-T2A-mtrCD19

<400>  783

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Asn Lys Ser Val 
        35                  40                  45              


Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly 
65                  70                  75                  80  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu 
                85                  90                  95      


Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly 
145                 150                 155                 160 


Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp 
                165                 170                 175     


Tyr Gly Ile His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys 
        195                 200                 205             


Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ile Lys Glu Lys His Leu 
            260                 265                 270         


Cys His Thr Gln Ser Ser Pro Lys Leu Phe Trp Ala Leu Val Val Val 
        275                 280                 285             


Ala Gly Val Leu Phe Cys Tyr Gly Leu Leu Val Thr Val Ala Leu Cys 
    290                 295                 300                 


Val Ile Trp Thr Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser Asp Tyr 
305                 310                 315                 320 


Met Asn Met Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln 
                325                 330                 335     


Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro Arg Ala Lys 
            340                 345                 350         


Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln 
        355                 360                 365             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    370                 375                 380                 


Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg 
385                 390                 395                 400 


Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys 
                405                 410                 415     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg 
            420                 425                 430         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        435                 440                 445             


Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg Ala Arg 
    450                 455                 460                 


Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
465                 470                 475                 480 


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Pro Ser Pro Leu Pro Val 
                485                 490                 495     


Ser Phe Leu Leu Phe Leu Thr Leu Val Gly Gly Arg Pro Gln Lys Ser 
            500                 505                 510         


Leu Leu Val Glu Val Glu Glu Gly Gly Asn Val Val Leu Pro Cys Leu 
        515                 520                 525             


Pro Asp Ser Ser Pro Val Ser Ser Glu Lys Leu Ala Trp Tyr Arg Gly 
    530                 535                 540                 


Asn Gln Ser Thr Pro Phe Leu Glu Leu Ser Pro Gly Ser Pro Gly Leu 
545                 550                 555                 560 


Gly Leu His Val Gly Ser Leu Gly Ile Leu Leu Val Ile Val Asn Val 
                565                 570                 575     


Ser Asp His Met Gly Gly Phe Tyr Leu Cys Gln Lys Arg Pro Pro Phe 
            580                 585                 590         


Lys Asp Ile Trp Gln Pro Ala Trp Thr Val Asn Val Glu Asp Ser Gly 
        595                 600                 605             


Glu Met Phe Arg Trp Asn Ala Ser Asp Val Arg Asp Leu Asp Cys Asp 
    610                 615                 620                 


Leu Arg Asn Arg Ser Ser Gly Ser His Arg Ser Thr Ser Gly Ser Gln 
625                 630                 635                 640 


Leu Tyr Val Trp Ala Lys Asp His Pro Lys Val Trp Gly Thr Lys Pro 
                645                 650                 655     


Val Cys Ala Pro Arg Gly Ser Ser Leu Asn Gln Ser Leu Ile Asn Gln 
            660                 665                 670         


Asp Leu Thr Val Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly Val 
        675                 680                 685             


Pro Pro Val Pro Val Ala Lys Gly Ser Ile Ser Trp Thr His Val His 
    690                 695                 700                 


Pro Arg Arg Pro Asn Val Ser Leu Leu Ser Leu Ser Leu Gly Gly Glu 
705                 710                 715                 720 


His Pro Val Arg Glu Met Trp Val Trp Gly Ser Leu Leu Leu Leu Pro 
                725                 730                 735     


Gln Ala Thr Ala Leu Asp Glu Gly Thr Tyr Tyr Cys Leu Arg Gly Asn 
            740                 745                 750         


Leu Thr Ile Glu Arg His Val Lys Val Ile Ala Arg Ser Ala Val Trp 
        755                 760                 765             


Leu Trp Leu Leu Arg Thr Gly Gly Trp Ile Val Pro Val Val Thr Leu 
    770                 775                 780                 


Val Tyr Val Ile Phe Cys Met Val Ser Leu Val Ala Phe Leu Tyr Cys 
785                 790                 795                 800 


Gln Arg Ala Phe Ile Leu Arg Arg Lys Arg Lys Arg Met Thr 
                805                 810                 


<210>  784
<211>  754
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mCD3zICS-mCD28CS-mTWEAK-T2A-mtrCD19

<400>  784

Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp 
1               5                   10                  15      


Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro 
            100                 105                 110         


Arg Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser Asp Tyr Met Asn Met 
        115                 120                 125             


Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala 
    130                 135                 140                 


Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro Ala Ala Arg Arg Ser Gln 
145                 150                 155                 160 


Arg Arg Arg Gly Arg Arg Gly Glu Pro Gly Thr Ala Leu Leu Ala Pro 
                165                 170                 175     


Leu Val Leu Ser Leu Gly Leu Ala Leu Ala Cys Leu Gly Leu Leu Leu 
            180                 185                 190         


Val Val Val Ser Leu Gly Ser Trp Ala Thr Leu Ser Ala Gln Glu Pro 
        195                 200                 205             


Ser Gln Glu Glu Leu Thr Ala Glu Asp Arg Arg Glu Pro Pro Glu Leu 
    210                 215                 220                 


Asn Pro Gln Thr Glu Glu Ser Gln Asp Val Val Pro Phe Leu Glu Gln 
225                 230                 235                 240 


Leu Val Arg Pro Arg Arg Ser Ala Pro Lys Gly Arg Lys Ala Arg Pro 
                245                 250                 255     


Arg Arg Ala Ile Ala Ala His Tyr Glu Val His Pro Arg Pro Gly Gln 
            260                 265                 270         


Asp Gly Ala Gln Ala Gly Val Asp Gly Thr Val Ser Gly Trp Glu Glu 
        275                 280                 285             


Thr Lys Ile Asn Ser Ser Ser Pro Leu Arg Tyr Asp Arg Gln Ile Gly 
    290                 295                 300                 


Glu Phe Thr Val Ile Arg Ala Gly Leu Tyr Tyr Leu Tyr Cys Gln Val 
305                 310                 315                 320 


His Phe Asp Glu Gly Lys Ala Val Tyr Leu Lys Leu Asp Leu Leu Val 
                325                 330                 335     


Asn Gly Val Leu Ala Leu Arg Cys Leu Glu Glu Phe Ser Ala Thr Ala 
            340                 345                 350         


Ala Ser Ser Pro Gly Pro Gln Leu Arg Leu Cys Gln Val Ser Gly Leu 
        355                 360                 365             


Leu Pro Leu Arg Pro Gly Ser Ser Leu Arg Ile Arg Thr Leu Pro Trp 
    370                 375                 380                 


Ala His Leu Lys Ala Ala Pro Phe Leu Thr Tyr Phe Gly Leu Phe Gln 
385                 390                 395                 400 


Val His Ala Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser 
                405                 410                 415     


Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Pro Ser 
            420                 425                 430         


Pro Leu Pro Val Ser Phe Leu Leu Phe Leu Thr Leu Val Gly Gly Arg 
        435                 440                 445             


Pro Gln Lys Ser Leu Leu Val Glu Val Glu Glu Gly Gly Asn Val Val 
    450                 455                 460                 


Leu Pro Cys Leu Pro Asp Ser Ser Pro Val Ser Ser Glu Lys Leu Ala 
465                 470                 475                 480 


Trp Tyr Arg Gly Asn Gln Ser Thr Pro Phe Leu Glu Leu Ser Pro Gly 
                485                 490                 495     


Ser Pro Gly Leu Gly Leu His Val Gly Ser Leu Gly Ile Leu Leu Val 
            500                 505                 510         


Ile Val Asn Val Ser Asp His Met Gly Gly Phe Tyr Leu Cys Gln Lys 
        515                 520                 525             


Arg Pro Pro Phe Lys Asp Ile Trp Gln Pro Ala Trp Thr Val Asn Val 
    530                 535                 540                 


Glu Asp Ser Gly Glu Met Phe Arg Trp Asn Ala Ser Asp Val Arg Asp 
545                 550                 555                 560 


Leu Asp Cys Asp Leu Arg Asn Arg Ser Ser Gly Ser His Arg Ser Thr 
                565                 570                 575     


Ser Gly Ser Gln Leu Tyr Val Trp Ala Lys Asp His Pro Lys Val Trp 
            580                 585                 590         


Gly Thr Lys Pro Val Cys Ala Pro Arg Gly Ser Ser Leu Asn Gln Ser 
        595                 600                 605             


Leu Ile Asn Gln Asp Leu Thr Val Ala Pro Gly Ser Thr Leu Trp Leu 
    610                 615                 620                 


Ser Cys Gly Val Pro Pro Val Pro Val Ala Lys Gly Ser Ile Ser Trp 
625                 630                 635                 640 


Thr His Val His Pro Arg Arg Pro Asn Val Ser Leu Leu Ser Leu Ser 
                645                 650                 655     


Leu Gly Gly Glu His Pro Val Arg Glu Met Trp Val Trp Gly Ser Leu 
            660                 665                 670         


Leu Leu Leu Pro Gln Ala Thr Ala Leu Asp Glu Gly Thr Tyr Tyr Cys 
        675                 680                 685             


Leu Arg Gly Asn Leu Thr Ile Glu Arg His Val Lys Val Ile Ala Arg 
    690                 695                 700                 


Ser Ala Val Trp Leu Trp Leu Leu Arg Thr Gly Gly Trp Ile Val Pro 
705                 710                 715                 720 


Val Val Thr Leu Val Tyr Val Ile Phe Cys Met Val Ser Leu Val Ala 
                725                 730                 735     


Phe Leu Tyr Cys Gln Arg Ala Phe Ile Leu Arg Arg Lys Arg Lys Arg 
            740                 745                 750         


Met Thr 
        


<210> 785

<400> 785
000

<210> 786

<400> 786
000

<210> 787

<400> 787
000

<210> 788

<400> 788
000

<210> 789

<400> 789
000

<210> 790

<400> 790
000

<210> 791

<400> 791
000

<210> 792

<400> 792
000

<210> 793

<400> 793
000

<210> 794

<400> 794
000

<210> 795

<400> 795
000

<210> 796

<400> 796
000

<210> 797

<400> 797
000

<210> 798

<400> 798
000

<210> 799

<400> 799
000

<210> 800

<400> 800
000

<210> 801

<400> 801
000

<210> 802

<400> 802
000

<210> 803

<400> 803
000

<210> 804

<400> 804
000

<210> 805

<400> 805
000

<210> 806

<400> 806
000

<210> 807

<400> 807
000

<210> 808

<400> 808
000

<210> 809

<400> 809
000

<210> 810

<400> 810
000

<210> 811

<400> 811
000

<210> 812

<400> 812
000

<210> 813

<400> 813
000

<210> 814

<400> 814
000

<210> 815

<400> 815
000

<210> 816

<400> 816
000

<210> 817

<400> 817
000

<210> 818

<400> 818
000

<210> 819

<400> 819
000

<210> 820

<400> 820
000

<210> 821

<400> 821
000

<210> 822

<400> 822
000

<210> 823

<400> 823
000

<210> 824

<400> 824
000

<210> 825

<400> 825
000

<210> 826

<400> 826
000

<210> 827

<400> 827
000

<210> 828

<400> 828
000

<210> 829

<400> 829
000

<210> 830

<400> 830
000

<210> 831

<400> 831
000

<210> 832

<400> 832
000

<210> 833

<400> 833
000

<210> 834

<400> 834
000

<210> 835

<400> 835
000

<210> 836

<400> 836
000

<210> 837

<400> 837
000

<210> 838

<400> 838
000

<210> 839

<400> 839
000

<210> 840

<400> 840
000

<210> 841

<400> 841
000

<210> 842

<400> 842
000

<210> 843

<400> 843
000

<210> 844

<400> 844
000


<210>  845
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse CD28 hinge (mCD28H)

<400>  845
atcaaggaga agcacctgtg ccacacccag agcagcccca agctg                       45


<210>  846
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse CD28 transmembrane domain (mCD28TM)

<400>  846
ttctgggccc tggtggtggt ggccggcgtg ctgttctgct acggcctgct ggtgaccgtg       60

gccctgtgcg tgatctggac c                                                 81


<210>  847
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse CD3 zeta intracellular signaling domain (mCD3zICS)

<400>  847
agggccaagt tcagcaggag cgccgagacc gccgccaacc tgcaggaccc caaccagctg       60

tacaacgagc tgaacctggg caggagggag gagtacgacg tgctggagaa gaagagggcc      120

agggaccccg agatgggcgg caagcagcag aggaggagga acccccagga gggcgtgtac      180

aacgccctgc agaaggacaa gatggccgag gcctacagcg agatcggcac caagggcgag      240

aggaggaggg gcaagggcca cgacggcctg taccagggcc tgagcaccgc caccaaggac      300

acctacgacg ccctgcacat gcagaccctg gcccccagg                             339



<210> 848

<400> 848
000

<210> 849

<400> 849
000

<210> 850

<400> 850
000


<210>  851
<211>  981
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse truncated CD19 (mtrCD19)

<400>  851
atgccatctc ctctgcctgt gtccttcctg ctgttcctga cactcgtcgg cggcagacct       60

cagaagtctc tgctggttga ggtggaagag ggcggcaatg tggtgctgcc ttgtctgcct      120

gatagcagcc ctgtgtccag cgagaagctg gcttggtaca gaggcaacca gagcacccca      180

tttctggaac tgagccctgg ctctcctgga ctgggactgc atgttggatc tctgggcatc      240

ctgctggtca tcgtgaacgt gtccgatcac atgggcggct tctacctgtg ccagaagagg      300

cctccattca aggacatctg gcagcctgcc tggaccgtga acgttgagga tagcggcgag      360

atgttcagat ggaacgccag cgacgtgcgc gacctggact gtgacctgag aaacagaagc      420

agcggcagcc acagaagcac ctctggctct cagctgtacg tgtgggccaa agatcacccc      480

aaagtgtggg gcaccaagcc tgtgtgtgct cctagaggca gcagcctgaa ccagagcctg      540

atcaaccagg acctgacagt ggctcctggc agcacactgt ggctgtcttg cggagttcct      600

ccagtgcctg tggccaaggg cagcatctct tggacacacg tgcaccctag aaggcccaac      660

gtgtccctgc tgtctctgtc tctcggcgga gaacatcccg tgcgcgagat gtgggtttgg      720

ggatctcttc tgctgctgcc acaggccaca gctctggatg agggcaccta ctactgcctg      780

aggggcaacc tgaccatcga gagacacgtg aaagtgatcg ccagatccgc cgtgtggctc      840

tggcttctta gaacaggcgg atggatcgtg cccgtggtca ccctggtgta cgtgatcttc      900

tgcatggtgt ccctggtggc cttcctgtac tgccagagag ccttcatcct gagaagaaag      960

cgcaagcgga tgacctgatg a                                                981



<210> 852

<400> 852
000

<210> 853

<400> 853
000

<210> 854

<400> 854
000

<210> 855

<400> 855
000


<210>  856
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse CD28 costimulatory domain (mCD28CS)

<400>  856
aacagcagga ggaacaggct gctgcagagc gactacatga acatgacccc caggaggccc       60

ggcctgacca ggaagcccta ccagccctac gcccccgcca gggacttcgc cgcctacagg      120

ccc                                                                    123


<210> 857

<400> 857
000

<210> 858

<400> 858
000

<210> 859

<400> 859
000


<210>  860
<211>  978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NbMMRm22.84-mCD28H-mCD28TM-mCD28CS-mCD3zICS

<400>  860
caggttcagc tgcaagagtc tggcggagga ctggttcaac ctggcggaag cctgagactg       60

tcttgtgccg cttctggcag aaccttcagc aactacgtga actacgccat gggctggttc      120

agacagttcc ccggcaaaga gagagagttc gtcgccagca tcagctggtc tagcgtgacc      180

acctactacg ccgacagcgt gaagggcaga ttcaccatca gcagagacaa cgccaagaac      240

accgtgtacc tgcagatgaa cagcctgaag ccagaggaca ccgccgtgta ctactgtgct      300

gctcacctgg ctcagtacag cgactacgcc tacagagatc cccaccagtt tggcgcttgg      360

ggccagggaa cacaagtgac cgttagctct atcaaggaga agcacctgtg ccacacccag      420

agcagcccca agctgttctg ggccctggtg gtggtggccg gcgtgctgtt ctgctacggc      480

ctgctggtga ccgtggccct gtgcgtgatc tggaccaaca gcaggaggaa caggctgctg      540

cagagcgact acatgaacat gacccccagg aggcccggcc tgaccaggaa gccctaccag      600

ccctacgccc ccgccaggga cttcgccgcc tacaggccca gggccaagtt cagcaggagc      660

gccgagaccg ccgccaacct gcaggacccc aaccagctgt acaacgagct gaacctgggc      720

aggagggagg agtacgacgt gctggagaag aagagggcca gggaccccga gatgggcggc      780

aagcagcaga ggaggaggaa cccccaggag ggcgtgtaca acgccctgca gaaggacaag      840

atggccgagg cctacagcga gatcggcacc aagggcgaga ggaggagggg caagggccac      900

gacggcctgt accagggcct gagcaccgcc accaaggaca cctacgacgc cctgcacatg      960

cagaccctgg cccccagg                                                    978


<210>  861
<211>  981
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NbMMRm5.38-mCD28H-mCD28TM-mCD28CS-mCD3zICS

<400>  861
caggttcagc tgcaagagtc tggcggagga ctggttcaag ctggcggaag cctgagactg       60

tcttgtgccg cttctggctt caccgacgac gactacgata tcggctggtt cagacaggcc      120

cctggcaaag agagagaggg cgtcagctgt atcagcagct ctgacggctc tacctactac      180

gccgacagcg tgaagggcag attcaccatc agcagcgaca acgccaagaa caccgtgtac      240

ctgcagatga actctctgaa gcccgaggac accgccgtgt actactgtgc cgccgacttc      300

ttcagatggg acagcggcag ctactacgtg cggggatgta gacacgccac ctacgattac      360

tggggccagg gcacacaagt gaccgtgtca tctatcaagg agaagcacct gtgccacacc      420

cagagcagcc ccaagctgtt ctgggccctg gtggtggtgg ccggcgtgct gttctgctac      480

ggcctgctgg tgaccgtggc cctgtgcgtg atctggacca acagcaggag gaacaggctg      540

ctgcagagcg actacatgaa catgaccccc aggaggcccg gcctgaccag gaagccctac      600

cagccctacg cccccgccag ggacttcgcc gcctacaggc ccagggccaa gttcagcagg      660

agcgccgaga ccgccgccaa cctgcaggac cccaaccagc tgtacaacga gctgaacctg      720

ggcaggaggg aggagtacga cgtgctggag aagaagaggg ccagggaccc cgagatgggc      780

ggcaagcagc agaggaggag gaacccccag gagggcgtgt acaacgccct gcagaaggac      840

aagatggccg aggcctacag cgagatcggc accaagggcg agaggaggag gggcaagggc      900

cacgacggcc tgtaccaggg cctgagcacc gccaccaagg acacctacga cgccctgcac      960

atgcagaccc tggcccccag g                                                981


<210>  862
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFvP4A8VHVL-mCD28H-mCD28TM-mCD28CS-mCD3zICS

<400>  862
caggtccagc tgcagcagtc tgggcctgag gtggtgaggc ctggggtctc agtgaagatt       60

tcctgcaagg gttccggcta cacattcact gattatggta tgcactgggt gaagcagagt      120

catgcaaaga gtctagagtg gattggagtt attagtactt acaatggtta tacaaactac      180

aaccagaagt ttaagggcaa ggccacaatg actgtagaca aatcctccag cacagcctat      240

atggaacttg ccagattgac atctgaggat tctgccatct attactgtgc aagagcctac      300

tatggtaacc tttactatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttccga cattgtgctg      420

acacagtctc ctgcttcctt agctgtatct ctggggcaga gggccaccat ctcatgcagg      480

gccagcaaaa gtgtcagtac atctagctat agttatatgc actggtacca acagaaacca      540

ggacagccac ccaaactcct catcaagtat gcatccaacc tagaatctgg ggtccctgcc      600

aggttcagtg gcagtgggtc tgggacagac ttcatcctca acatccatcc agtggaggag      660

gaggatgctg caacctatta ctgtcagcac agtagggagc ttccattcac gttcggctcg      720

gggacaaagt tggaaataaa aatcaaggag aagcacctgt gccacaccca gagcagcccc      780

aagctgttct gggccctggt ggtggtggcc ggcgtgctgt tctgctacgg cctgctggtg      840

accgtggccc tgtgcgtgat ctggaccaac agcaggagga acaggctgct gcagagcgac      900

tacatgaaca tgacccccag gaggcccggc ctgaccagga agccctacca gccctacgcc      960

cccgccaggg acttcgccgc ctacaggccc agggccaagt tcagcaggag cgccgagacc     1020

gccgccaacc tgcaggaccc caaccagctg tacaacgagc tgaacctggg caggagggag     1080

gagtacgacg tgctggagaa gaagagggcc agggaccccg agatgggcgg caagcagcag     1140

aggaggagga acccccagga gggcgtgtac aacgccctgc agaaggacaa gatggccgag     1200

gcctacagcg agatcggcac caagggcgag aggaggaggg gcaagggcca cgacggcctg     1260

taccagggcc tgagcaccgc caccaaggac acctacgacg ccctgcacat gcagaccctg     1320

gcccccagg                                                             1329


<210>  863
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFvP4A8VLVH-mCD28H-mCD28TM-mCD28CS-mCD3zICS

<400>  863
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt acatctagct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcatcct caacatccat      240

ccagtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttccattc      300

acgttcggct cggggacaaa gttggaaata aaaggtggtg gtggttctgg cggcggcggc      360

tccggtggtg gtggttccca ggtccagctg cagcagtctg ggcctgaggt ggtgaggcct      420

ggggtctcag tgaagatttc ctgcaagggt tccggctaca cattcactga ttatggtatg      480

cactgggtga agcagagtca tgcaaagagt ctagagtgga ttggagttat tagtacttac      540

aatggttata caaactacaa ccagaagttt aagggcaagg ccacaatgac tgtagacaaa      600

tcctccagca cagcctatat ggaacttgcc agattgacat ctgaggattc tgccatctat      660

tactgtgcaa gagcctacta tggtaacctt tactatgcta tggactactg gggtcaagga      720

acctcagtca ccgtctcctc aatcaaggag aagcacctgt gccacaccca gagcagcccc      780

aagctgttct gggccctggt ggtggtggcc ggcgtgctgt tctgctacgg cctgctggtg      840

accgtggccc tgtgcgtgat ctggaccaac agcaggagga acaggctgct gcagagcgac      900

tacatgaaca tgacccccag gaggcccggc ctgaccagga agccctacca gccctacgcc      960

cccgccaggg acttcgccgc ctacaggccc agggccaagt tcagcaggag cgccgagacc     1020

gccgccaacc tgcaggaccc caaccagctg tacaacgagc tgaacctggg caggagggag     1080

gagtacgacg tgctggagaa gaagagggcc agggaccccg agatgggcgg caagcagcag     1140

aggaggagga acccccagga gggcgtgtac aacgccctgc agaaggacaa gatggccgag     1200

gcctacagcg agatcggcac caagggcgag aggaggaggg gcaagggcca cgacggcctg     1260

taccagggcc tgagcaccgc caccaaggac acctacgacg ccctgcacat gcagaccctg     1320

gcccccagg                                                             1329


<210>  864
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFvP3G5VHVL-mCD28H-mCD28TM-mCD28CS-mCD3zICS

<400>  864
caggtccagc tgcagcagtc tgggcctgag gtggtgaggc ctggggtctc agtgaagatt       60

tcctgcaagg gttccggcta cacattcact gattatggta tacactgggt gaagcagagt      120

catgcaaaga gtctagagtg gattggagtt attagtactt acaatggtta tacaaactac      180

aaccagaagt ttaagggcaa ggccacaatg actgtagaca aatcctccag cacagcctat      240

atggaacttg ccagattgac atctgaggat tctgccatct attactgtgc aagagcctac      300

tatggtaacc tttactatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttccga cattgtgctg      420

acacagtctc ctgcttcctt agctgtatct ctggggcaga gggccaccat ctcatgcagg      480

gccaacaaaa gtgtcagtac atctagctat agttatatgc actggtacca acagaaacca      540

ggacagccac ccaaactcct catcaagtat gcatccaacc tagaatctgg ggtccctgcc      600

aggttcagtg gcagtgggtc tgggacagac ttcatcctca acatccatcc agtggaggag      660

gaggatgctg caacctatta ctgtcagcac agtagggagc ttccattcac gttcggctcg      720

gggacaaagt tggaaataaa aatcaaggag aagcacctgt gccacaccca gagcagcccc      780

aagctgttct gggccctggt ggtggtggcc ggcgtgctgt tctgctacgg cctgctggtg      840

accgtggccc tgtgcgtgat ctggaccaac agcaggagga acaggctgct gcagagcgac      900

tacatgaaca tgacccccag gaggcccggc ctgaccagga agccctacca gccctacgcc      960

cccgccaggg acttcgccgc ctacaggccc agggccaagt tcagcaggag cgccgagacc     1020

gccgccaacc tgcaggaccc caaccagctg tacaacgagc tgaacctggg caggagggag     1080

gagtacgacg tgctggagaa gaagagggcc agggaccccg agatgggcgg caagcagcag     1140

aggaggagga acccccagga gggcgtgtac aacgccctgc agaaggacaa gatggccgag     1200

gcctacagcg agatcggcac caagggcgag aggaggaggg gcaagggcca cgacggcctg     1260

taccagggcc tgagcaccgc caccaaggac acctacgacg ccctgcacat gcagaccctg     1320

gcccccagg                                                             1329


<210>  865
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFvP3G5VLVH-mCD28H-mCD28TM-mCD28CS-mCD3zICS

<400>  865
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccaacaa aagtgtcagt acatctagct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcatcct caacatccat      240

ccagtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttccattc      300

acgttcggct cggggacaaa gttggaaata aaaggtggtg gtggttctgg cggcggcggc      360

tccggtggtg gtggttccca ggtccagctg cagcagtctg ggcctgaggt ggtgaggcct      420

ggggtctcag tgaagatttc ctgcaagggt tccggctaca cattcactga ttatggtata      480

cactgggtga agcagagtca tgcaaagagt ctagagtgga ttggagttat tagtacttac      540

aatggttata caaactacaa ccagaagttt aagggcaagg ccacaatgac tgtagacaaa      600

tcctccagca cagcctatat ggaacttgcc agattgacat ctgaggattc tgccatctat      660

tactgtgcaa gagcctacta tggtaacctt tactatgcta tggactactg gggtcaagga      720

acctcagtca ccgtctcctc aatcaaggag aagcacctgt gccacaccca gagcagcccc      780

aagctgttct gggccctggt ggtggtggcc ggcgtgctgt tctgctacgg cctgctggtg      840

accgtggccc tgtgcgtgat ctggaccaac agcaggagga acaggctgct gcagagcgac      900

tacatgaaca tgacccccag gaggcccggc ctgaccagga agccctacca gccctacgcc      960

cccgccaggg acttcgccgc ctacaggccc agggccaagt tcagcaggag cgccgagacc     1020

gccgccaacc tgcaggaccc caaccagctg tacaacgagc tgaacctggg caggagggag     1080

gagtacgacg tgctggagaa gaagagggcc agggaccccg agatgggcgg caagcagcag     1140

aggaggagga acccccagga gggcgtgtac aacgccctgc agaaggacaa gatggccgag     1200

gcctacagcg agatcggcac caagggcgag aggaggaggg gcaagggcca cgacggcctg     1260

taccagggcc tgagcaccgc caccaaggac acctacgacg ccctgcacat gcagaccctg     1320

gcccccagg                                                             1329


<210>  866
<211>  1209
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mCD3zICS-mCD28CS-mTWEAK

<400>  866
agggccaagt tcagcaggag cgccgagacc gccgccaacc tgcaggaccc caaccagctg       60

tacaacgagc tgaacctggg caggagggag gagtacgacg tgctggagaa gaagagggcc      120

agggaccccg agatgggcgg caagcagcag aggaggagga acccccagga gggcgtgtac      180

aacgccctgc agaaggacaa gatggccgag gcctacagcg agatcggcac caagggcgag      240

aggaggaggg gcaagggcca cgacggcctg taccagggcc tgagcaccgc caccaaggac      300

acctacgacg ccctgcacat gcagaccctg gcccccagga acagcaggag gaacaggctg      360

ctgcagagcg actacatgaa catgaccccc aggaggcccg gcctgaccag gaagccctac      420

cagccctacg cccccgccag ggacttcgcc gcctacaggc ccgccgcccg tcggagccag      480

aggcggaggg ggcgccgggg ggagccgggc accgccctgc tggccccgct ggtgctgagc      540

ctgggcctgg cgctggcctg ccttggcctc ctgctggtcg tggtcagcct ggggagctgg      600

gcaacgctgt ctgcccagga gccttctcag gaggagctga cagcagagga ccgccgggag      660

ccccctgaac tgaatcccca gacagaggaa agccaggatg tggtaccttt cttggaacaa      720

ctagtccggc ctcgaagaag tgctcctaaa ggccggaagg cgcggcctcg ccgagctatt      780

gcagcccatt atgaggttca tcctcggcca ggacaggatg gagcacaagc aggtgtggat      840

gggacagtga gtggctggga agagaccaaa atcaacagct ccagccctct gcgctacgac      900

cgccagattg gggaatttac agtcatcagg gctgggctct actacctgta ctgtcaggtg      960

cactttgatg agggaaaggc tgtctacctg aagctggact tgctggtgaa cggtgtgctg     1020

gccctgcgct gcctggaaga attctcagcc acagcagcaa gctctcctgg gccccagctc     1080

cgtttgtgcc aggtgtctgg gctgttgccg ctgcggccag ggtcttccct tcggatccgc     1140

accctcccct gggctcatct taaggctgcc cccttcctaa cctactttgg actctttcaa     1200

gttcactga                                                             1209



<210> 867

<400> 867
000

<210> 868

<400> 868
000

<210> 869

<400> 869
000

<210> 870

<400> 870
000

<210> 871

<400> 871
000

<210> 872

<400> 872
000

<210> 873

<400> 873
000

<210> 874

<400> 874
000

<210> 875

<400> 875
000

<210> 876

<400> 876
000

<210> 877

<400> 877
000


<210>  878
<211>  2097
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm22.84-mCD28H-mCD28TM-mCD28CS-mCD3zICS-T2A-mtrCD19

<400>  878
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gttcagctgc aagagtctgg cggaggactg gttcaacctg gcggaagcct gagactgtct      120

tgtgccgctt ctggcagaac cttcagcaac tacgtgaact acgccatggg ctggttcaga      180

cagttccccg gcaaagagag agagttcgtc gccagcatca gctggtctag cgtgaccacc      240

tactacgccg acagcgtgaa gggcagattc accatcagca gagacaacgc caagaacacc      300

gtgtacctgc agatgaacag cctgaagcca gaggacaccg ccgtgtacta ctgtgctgct      360

cacctggctc agtacagcga ctacgcctac agagatcccc accagtttgg cgcttggggc      420

cagggaacac aagtgaccgt tagctctatc aaggagaagc acctgtgcca cacccagagc      480

agccccaagc tgttctgggc cctggtggtg gtggccggcg tgctgttctg ctacggcctg      540

ctggtgaccg tggccctgtg cgtgatctgg accaacagca ggaggaacag gctgctgcag      600

agcgactaca tgaacatgac ccccaggagg cccggcctga ccaggaagcc ctaccagccc      660

tacgcccccg ccagggactt cgccgcctac aggcccaggg ccaagttcag caggagcgcc      720

gagaccgccg ccaacctgca ggaccccaac cagctgtaca acgagctgaa cctgggcagg      780

agggaggagt acgacgtgct ggagaagaag agggccaggg accccgagat gggcggcaag      840

cagcagagga ggaggaaccc ccaggagggc gtgtacaacg ccctgcagaa ggacaagatg      900

gccgaggcct acagcgagat cggcaccaag ggcgagagga ggaggggcaa gggccacgac      960

ggcctgtacc agggcctgag caccgccacc aaggacacct acgacgccct gcacatgcag     1020

accctggccc ccagggccag ggccaaaagg tctggctccg gtgagggcag aggaagtctt     1080

ctaacatgcg gtgacgtgga ggagaatccc ggccctatgc catctcctct gcctgtgtcc     1140

ttcctgctgt tcctgacact cgtcggcggc agacctcaga agtctctgct ggttgaggtg     1200

gaagagggcg gcaatgtggt gctgccttgt ctgcctgata gcagccctgt gtccagcgag     1260

aagctggctt ggtacagagg caaccagagc accccatttc tggaactgag ccctggctct     1320

cctggactgg gactgcatgt tggatctctg ggcatcctgc tggtcatcgt gaacgtgtcc     1380

gatcacatgg gcggcttcta cctgtgccag aagaggcctc cattcaagga catctggcag     1440

cctgcctgga ccgtgaacgt tgaggatagc ggcgagatgt tcagatggaa cgccagcgac     1500

gtgcgcgacc tggactgtga cctgagaaac agaagcagcg gcagccacag aagcacctct     1560

ggctctcagc tgtacgtgtg ggccaaagat caccccaaag tgtggggcac caagcctgtg     1620

tgtgctccta gaggcagcag cctgaaccag agcctgatca accaggacct gacagtggct     1680

cctggcagca cactgtggct gtcttgcgga gttcctccag tgcctgtggc caagggcagc     1740

atctcttgga cacacgtgca ccctagaagg cccaacgtgt ccctgctgtc tctgtctctc     1800

ggcggagaac atcccgtgcg cgagatgtgg gtttggggat ctcttctgct gctgccacag     1860

gccacagctc tggatgaggg cacctactac tgcctgaggg gcaacctgac catcgagaga     1920

cacgtgaaag tgatcgccag atccgccgtg tggctctggc ttcttagaac aggcggatgg     1980

atcgtgcccg tggtcaccct ggtgtacgtg atcttctgca tggtgtccct ggtggccttc     2040

ctgtactgcc agagagcctt catcctgaga agaaagcgca agcggatgac ctgatga        2097


<210>  879
<211>  2100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-NbMMRm5.38-mCD28H-mCD28TM-mCD28CS-mCD3zICS-T2A-mtrCD19

<400>  879
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gttcagctgc aagagtctgg cggaggactg gttcaagctg gcggaagcct gagactgtct      120

tgtgccgctt ctggcttcac cgacgacgac tacgatatcg gctggttcag acaggcccct      180

ggcaaagaga gagagggcgt cagctgtatc agcagctctg acggctctac ctactacgcc      240

gacagcgtga agggcagatt caccatcagc agcgacaacg ccaagaacac cgtgtacctg      300

cagatgaact ctctgaagcc cgaggacacc gccgtgtact actgtgccgc cgacttcttc      360

agatgggaca gcggcagcta ctacgtgcgg ggatgtagac acgccaccta cgattactgg      420

ggccagggca cacaagtgac cgtgtcatct atcaaggaga agcacctgtg ccacacccag      480

agcagcccca agctgttctg ggccctggtg gtggtggccg gcgtgctgtt ctgctacggc      540

ctgctggtga ccgtggccct gtgcgtgatc tggaccaaca gcaggaggaa caggctgctg      600

cagagcgact acatgaacat gacccccagg aggcccggcc tgaccaggaa gccctaccag      660

ccctacgccc ccgccaggga cttcgccgcc tacaggccca gggccaagtt cagcaggagc      720

gccgagaccg ccgccaacct gcaggacccc aaccagctgt acaacgagct gaacctgggc      780

aggagggagg agtacgacgt gctggagaag aagagggcca gggaccccga gatgggcggc      840

aagcagcaga ggaggaggaa cccccaggag ggcgtgtaca acgccctgca gaaggacaag      900

atggccgagg cctacagcga gatcggcacc aagggcgaga ggaggagggg caagggccac      960

gacggcctgt accagggcct gagcaccgcc accaaggaca cctacgacgc cctgcacatg     1020

cagaccctgg cccccagggc cagggccaaa aggtctggct ccggtgaggg cagaggaagt     1080

cttctaacat gcggtgacgt ggaggagaat cccggcccta tgccatctcc tctgcctgtg     1140

tccttcctgc tgttcctgac actcgtcggc ggcagacctc agaagtctct gctggttgag     1200

gtggaagagg gcggcaatgt ggtgctgcct tgtctgcctg atagcagccc tgtgtccagc     1260

gagaagctgg cttggtacag aggcaaccag agcaccccat ttctggaact gagccctggc     1320

tctcctggac tgggactgca tgttggatct ctgggcatcc tgctggtcat cgtgaacgtg     1380

tccgatcaca tgggcggctt ctacctgtgc cagaagaggc ctccattcaa ggacatctgg     1440

cagcctgcct ggaccgtgaa cgttgaggat agcggcgaga tgttcagatg gaacgccagc     1500

gacgtgcgcg acctggactg tgacctgaga aacagaagca gcggcagcca cagaagcacc     1560

tctggctctc agctgtacgt gtgggccaaa gatcacccca aagtgtgggg caccaagcct     1620

gtgtgtgctc ctagaggcag cagcctgaac cagagcctga tcaaccagga cctgacagtg     1680

gctcctggca gcacactgtg gctgtcttgc ggagttcctc cagtgcctgt ggccaagggc     1740

agcatctctt ggacacacgt gcaccctaga aggcccaacg tgtccctgct gtctctgtct     1800

ctcggcggag aacatcccgt gcgcgagatg tgggtttggg gatctcttct gctgctgcca     1860

caggccacag ctctggatga gggcacctac tactgcctga ggggcaacct gaccatcgag     1920

agacacgtga aagtgatcgc cagatccgcc gtgtggctct ggcttcttag aacaggcgga     1980

tggatcgtgc ccgtggtcac cctggtgtac gtgatcttct gcatggtgtc cctggtggcc     2040

ttcctgtact gccagagagc cttcatcctg agaagaaagc gcaagcggat gacctgatga     2100


<210>  880
<211>  2448
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VHVL-mCD28H-mCD28TM-mCD28CS-mCD3zICS-T2A-mtrCD19

<400>  880
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gtccagctgc agcagtctgg gcctgaggtg gtgaggcctg gggtctcagt gaagatttcc      120

tgcaagggtt ccggctacac attcactgat tatggtatgc actgggtgaa gcagagtcat      180

gcaaagagtc tagagtggat tggagttatt agtacttaca atggttatac aaactacaac      240

cagaagttta agggcaaggc cacaatgact gtagacaaat cctccagcac agcctatatg      300

gaacttgcca gattgacatc tgaggattct gccatctatt actgtgcaag agcctactat      360

ggtaaccttt actatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      420

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgacat tgtgctgaca      480

cagtctcctg cttccttagc tgtatctctg gggcagaggg ccaccatctc atgcagggcc      540

agcaaaagtg tcagtacatc tagctatagt tatatgcact ggtaccaaca gaaaccagga      600

cagccaccca aactcctcat caagtatgca tccaacctag aatctggggt ccctgccagg      660

ttcagtggca gtgggtctgg gacagacttc atcctcaaca tccatccagt ggaggaggag      720

gatgctgcaa cctattactg tcagcacagt agggagcttc cattcacgtt cggctcgggg      780

acaaagttgg aaataaaaat caaggagaag cacctgtgcc acacccagag cagccccaag      840

ctgttctggg ccctggtggt ggtggccggc gtgctgttct gctacggcct gctggtgacc      900

gtggccctgt gcgtgatctg gaccaacagc aggaggaaca ggctgctgca gagcgactac      960

atgaacatga cccccaggag gcccggcctg accaggaagc cctaccagcc ctacgccccc     1020

gccagggact tcgccgccta caggcccagg gccaagttca gcaggagcgc cgagaccgcc     1080

gccaacctgc aggaccccaa ccagctgtac aacgagctga acctgggcag gagggaggag     1140

tacgacgtgc tggagaagaa gagggccagg gaccccgaga tgggcggcaa gcagcagagg     1200

aggaggaacc cccaggaggg cgtgtacaac gccctgcaga aggacaagat ggccgaggcc     1260

tacagcgaga tcggcaccaa gggcgagagg aggaggggca agggccacga cggcctgtac     1320

cagggcctga gcaccgccac caaggacacc tacgacgccc tgcacatgca gaccctggcc     1380

cccagggcca gggccaaaag gtctggctcc ggtgagggca gaggaagtct tctaacatgc     1440

ggtgacgtgg aggagaatcc cggccctatg ccatctcctc tgcctgtgtc cttcctgctg     1500

ttcctgacac tcgtcggcgg cagacctcag aagtctctgc tggttgaggt ggaagagggc     1560

ggcaatgtgg tgctgccttg tctgcctgat agcagccctg tgtccagcga gaagctggct     1620

tggtacagag gcaaccagag caccccattt ctggaactga gccctggctc tcctggactg     1680

ggactgcatg ttggatctct gggcatcctg ctggtcatcg tgaacgtgtc cgatcacatg     1740

ggcggcttct acctgtgcca gaagaggcct ccattcaagg acatctggca gcctgcctgg     1800

accgtgaacg ttgaggatag cggcgagatg ttcagatgga acgccagcga cgtgcgcgac     1860

ctggactgtg acctgagaaa cagaagcagc ggcagccaca gaagcacctc tggctctcag     1920

ctgtacgtgt gggccaaaga tcaccccaaa gtgtggggca ccaagcctgt gtgtgctcct     1980

agaggcagca gcctgaacca gagcctgatc aaccaggacc tgacagtggc tcctggcagc     2040

acactgtggc tgtcttgcgg agttcctcca gtgcctgtgg ccaagggcag catctcttgg     2100

acacacgtgc accctagaag gcccaacgtg tccctgctgt ctctgtctct cggcggagaa     2160

catcccgtgc gcgagatgtg ggtttgggga tctcttctgc tgctgccaca ggccacagct     2220

ctggatgagg gcacctacta ctgcctgagg ggcaacctga ccatcgagag acacgtgaaa     2280

gtgatcgcca gatccgccgt gtggctctgg cttcttagaa caggcggatg gatcgtgccc     2340

gtggtcaccc tggtgtacgt gatcttctgc atggtgtccc tggtggcctt cctgtactgc     2400

cagagagcct tcatcctgag aagaaagcgc aagcggatga cctgatga                  2448


<210>  881
<211>  2448
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP4A8VLVH-mCD28H-mCD28TM-mCD28CS-mCD3zICS-T2A-mtrCD19

<400>  881
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagcgac       60

attgtgctga cacagtctcc tgcttcctta gctgtatctc tggggcagag ggccaccatc      120

tcatgcaggg ccagcaaaag tgtcagtaca tctagctata gttatatgca ctggtaccaa      180

cagaaaccag gacagccacc caaactcctc atcaagtatg catccaacct agaatctggg      240

gtccctgcca ggttcagtgg cagtgggtct gggacagact tcatcctcaa catccatcca      300

gtggaggagg aggatgctgc aacctattac tgtcagcaca gtagggagct tccattcacg      360

ttcggctcgg ggacaaagtt ggaaataaaa ggtggtggtg gttctggcgg cggcggctcc      420

ggtggtggtg gttcccaggt ccagctgcag cagtctgggc ctgaggtggt gaggcctggg      480

gtctcagtga agatttcctg caagggttcc ggctacacat tcactgatta tggtatgcac      540

tgggtgaagc agagtcatgc aaagagtcta gagtggattg gagttattag tacttacaat      600

ggttatacaa actacaacca gaagtttaag ggcaaggcca caatgactgt agacaaatcc      660

tccagcacag cctatatgga acttgccaga ttgacatctg aggattctgc catctattac      720

tgtgcaagag cctactatgg taacctttac tatgctatgg actactgggg tcaaggaacc      780

tcagtcaccg tctcctcaat caaggagaag cacctgtgcc acacccagag cagccccaag      840

ctgttctggg ccctggtggt ggtggccggc gtgctgttct gctacggcct gctggtgacc      900

gtggccctgt gcgtgatctg gaccaacagc aggaggaaca ggctgctgca gagcgactac      960

atgaacatga cccccaggag gcccggcctg accaggaagc cctaccagcc ctacgccccc     1020

gccagggact tcgccgccta caggcccagg gccaagttca gcaggagcgc cgagaccgcc     1080

gccaacctgc aggaccccaa ccagctgtac aacgagctga acctgggcag gagggaggag     1140

tacgacgtgc tggagaagaa gagggccagg gaccccgaga tgggcggcaa gcagcagagg     1200

aggaggaacc cccaggaggg cgtgtacaac gccctgcaga aggacaagat ggccgaggcc     1260

tacagcgaga tcggcaccaa gggcgagagg aggaggggca agggccacga cggcctgtac     1320

cagggcctga gcaccgccac caaggacacc tacgacgccc tgcacatgca gaccctggcc     1380

cccagggcca gggccaaaag gtctggctcc ggtgagggca gaggaagtct tctaacatgc     1440

ggtgacgtgg aggagaatcc cggccctatg ccatctcctc tgcctgtgtc cttcctgctg     1500

ttcctgacac tcgtcggcgg cagacctcag aagtctctgc tggttgaggt ggaagagggc     1560

ggcaatgtgg tgctgccttg tctgcctgat agcagccctg tgtccagcga gaagctggct     1620

tggtacagag gcaaccagag caccccattt ctggaactga gccctggctc tcctggactg     1680

ggactgcatg ttggatctct gggcatcctg ctggtcatcg tgaacgtgtc cgatcacatg     1740

ggcggcttct acctgtgcca gaagaggcct ccattcaagg acatctggca gcctgcctgg     1800

accgtgaacg ttgaggatag cggcgagatg ttcagatgga acgccagcga cgtgcgcgac     1860

ctggactgtg acctgagaaa cagaagcagc ggcagccaca gaagcacctc tggctctcag     1920

ctgtacgtgt gggccaaaga tcaccccaaa gtgtggggca ccaagcctgt gtgtgctcct     1980

agaggcagca gcctgaacca gagcctgatc aaccaggacc tgacagtggc tcctggcagc     2040

acactgtggc tgtcttgcgg agttcctcca gtgcctgtgg ccaagggcag catctcttgg     2100

acacacgtgc accctagaag gcccaacgtg tccctgctgt ctctgtctct cggcggagaa     2160

catcccgtgc gcgagatgtg ggtttgggga tctcttctgc tgctgccaca ggccacagct     2220

ctggatgagg gcacctacta ctgcctgagg ggcaacctga ccatcgagag acacgtgaaa     2280

gtgatcgcca gatccgccgt gtggctctgg cttcttagaa caggcggatg gatcgtgccc     2340

gtggtcaccc tggtgtacgt gatcttctgc atggtgtccc tggtggcctt cctgtactgc     2400

cagagagcct tcatcctgag aagaaagcgc aagcggatga cctgatga                  2448


<210>  882
<211>  2448
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VHVL-mCD28H-mCD28TM-mCD28CS-mCD3zICS-T2A-mtrCD19

<400>  882
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagccag       60

gtccagctgc agcagtctgg gcctgaggtg gtgaggcctg gggtctcagt gaagatttcc      120

tgcaagggtt ccggctacac attcactgat tatggtatac actgggtgaa gcagagtcat      180

gcaaagagtc tagagtggat tggagttatt agtacttaca atggttatac aaactacaac      240

cagaagttta agggcaaggc cacaatgact gtagacaaat cctccagcac agcctatatg      300

gaacttgcca gattgacatc tgaggattct gccatctatt actgtgcaag agcctactat      360

ggtaaccttt actatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      420

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgacat tgtgctgaca      480

cagtctcctg cttccttagc tgtatctctg gggcagaggg ccaccatctc atgcagggcc      540

aacaaaagtg tcagtacatc tagctatagt tatatgcact ggtaccaaca gaaaccagga      600

cagccaccca aactcctcat caagtatgca tccaacctag aatctggggt ccctgccagg      660

ttcagtggca gtgggtctgg gacagacttc atcctcaaca tccatccagt ggaggaggag      720

gatgctgcaa cctattactg tcagcacagt agggagcttc cattcacgtt cggctcgggg      780

acaaagttgg aaataaaaat caaggagaag cacctgtgcc acacccagag cagccccaag      840

ctgttctggg ccctggtggt ggtggccggc gtgctgttct gctacggcct gctggtgacc      900

gtggccctgt gcgtgatctg gaccaacagc aggaggaaca ggctgctgca gagcgactac      960

atgaacatga cccccaggag gcccggcctg accaggaagc cctaccagcc ctacgccccc     1020

gccagggact tcgccgccta caggcccagg gccaagttca gcaggagcgc cgagaccgcc     1080

gccaacctgc aggaccccaa ccagctgtac aacgagctga acctgggcag gagggaggag     1140

tacgacgtgc tggagaagaa gagggccagg gaccccgaga tgggcggcaa gcagcagagg     1200

aggaggaacc cccaggaggg cgtgtacaac gccctgcaga aggacaagat ggccgaggcc     1260

tacagcgaga tcggcaccaa gggcgagagg aggaggggca agggccacga cggcctgtac     1320

cagggcctga gcaccgccac caaggacacc tacgacgccc tgcacatgca gaccctggcc     1380

cccagggcca gggccaaaag gtctggctcc ggtgagggca gaggaagtct tctaacatgc     1440

ggtgacgtgg aggagaatcc cggccctatg ccatctcctc tgcctgtgtc cttcctgctg     1500

ttcctgacac tcgtcggcgg cagacctcag aagtctctgc tggttgaggt ggaagagggc     1560

ggcaatgtgg tgctgccttg tctgcctgat agcagccctg tgtccagcga gaagctggct     1620

tggtacagag gcaaccagag caccccattt ctggaactga gccctggctc tcctggactg     1680

ggactgcatg ttggatctct gggcatcctg ctggtcatcg tgaacgtgtc cgatcacatg     1740

ggcggcttct acctgtgcca gaagaggcct ccattcaagg acatctggca gcctgcctgg     1800

accgtgaacg ttgaggatag cggcgagatg ttcagatgga acgccagcga cgtgcgcgac     1860

ctggactgtg acctgagaaa cagaagcagc ggcagccaca gaagcacctc tggctctcag     1920

ctgtacgtgt gggccaaaga tcaccccaaa gtgtggggca ccaagcctgt gtgtgctcct     1980

agaggcagca gcctgaacca gagcctgatc aaccaggacc tgacagtggc tcctggcagc     2040

acactgtggc tgtcttgcgg agttcctcca gtgcctgtgg ccaagggcag catctcttgg     2100

acacacgtgc accctagaag gcccaacgtg tccctgctgt ctctgtctct cggcggagaa     2160

catcccgtgc gcgagatgtg ggtttgggga tctcttctgc tgctgccaca ggccacagct     2220

ctggatgagg gcacctacta ctgcctgagg ggcaacctga ccatcgagag acacgtgaaa     2280

gtgatcgcca gatccgccgt gtggctctgg cttcttagaa caggcggatg gatcgtgccc     2340

gtggtcaccc tggtgtacgt gatcttctgc atggtgtccc tggtggcctt cctgtactgc     2400

cagagagcct tcatcctgag aagaaagcgc aagcggatga cctgatga                  2448


<210>  883
<211>  2448
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LS-scFvP3G5VLVH-mCD28H-mCD28TM-mCD28CS-mCD3zICS-T2A-mtrCD19

<400>  883
atggagtgga cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcacagcgac       60

attgtgctga cacagtctcc tgcttcctta gctgtatctc tggggcagag ggccaccatc      120

tcatgcaggg ccaacaaaag tgtcagtaca tctagctata gttatatgca ctggtaccaa      180

cagaaaccag gacagccacc caaactcctc atcaagtatg catccaacct agaatctggg      240

gtccctgcca ggttcagtgg cagtgggtct gggacagact tcatcctcaa catccatcca      300

gtggaggagg aggatgctgc aacctattac tgtcagcaca gtagggagct tccattcacg      360

ttcggctcgg ggacaaagtt ggaaataaaa ggtggtggtg gttctggcgg cggcggctcc      420

ggtggtggtg gttcccaggt ccagctgcag cagtctgggc ctgaggtggt gaggcctggg      480

gtctcagtga agatttcctg caagggttcc ggctacacat tcactgatta tggtatacac      540

tgggtgaagc agagtcatgc aaagagtcta gagtggattg gagttattag tacttacaat      600

ggttatacaa actacaacca gaagtttaag ggcaaggcca caatgactgt agacaaatcc      660

tccagcacag cctatatgga acttgccaga ttgacatctg aggattctgc catctattac      720

tgtgcaagag cctactatgg taacctttac tatgctatgg actactgggg tcaaggaacc      780

tcagtcaccg tctcctcaat caaggagaag cacctgtgcc acacccagag cagccccaag      840

ctgttctggg ccctggtggt ggtggccggc gtgctgttct gctacggcct gctggtgacc      900

gtggccctgt gcgtgatctg gaccaacagc aggaggaaca ggctgctgca gagcgactac      960

atgaacatga cccccaggag gcccggcctg accaggaagc cctaccagcc ctacgccccc     1020

gccagggact tcgccgccta caggcccagg gccaagttca gcaggagcgc cgagaccgcc     1080

gccaacctgc aggaccccaa ccagctgtac aacgagctga acctgggcag gagggaggag     1140

tacgacgtgc tggagaagaa gagggccagg gaccccgaga tgggcggcaa gcagcagagg     1200

aggaggaacc cccaggaggg cgtgtacaac gccctgcaga aggacaagat ggccgaggcc     1260

tacagcgaga tcggcaccaa gggcgagagg aggaggggca agggccacga cggcctgtac     1320

cagggcctga gcaccgccac caaggacacc tacgacgccc tgcacatgca gaccctggcc     1380

cccagggcca gggccaaaag gtctggctcc ggtgagggca gaggaagtct tctaacatgc     1440

ggtgacgtgg aggagaatcc cggccctatg ccatctcctc tgcctgtgtc cttcctgctg     1500

ttcctgacac tcgtcggcgg cagacctcag aagtctctgc tggttgaggt ggaagagggc     1560

ggcaatgtgg tgctgccttg tctgcctgat agcagccctg tgtccagcga gaagctggct     1620

tggtacagag gcaaccagag caccccattt ctggaactga gccctggctc tcctggactg     1680

ggactgcatg ttggatctct gggcatcctg ctggtcatcg tgaacgtgtc cgatcacatg     1740

ggcggcttct acctgtgcca gaagaggcct ccattcaagg acatctggca gcctgcctgg     1800

accgtgaacg ttgaggatag cggcgagatg ttcagatgga acgccagcga cgtgcgcgac     1860

ctggactgtg acctgagaaa cagaagcagc ggcagccaca gaagcacctc tggctctcag     1920

ctgtacgtgt gggccaaaga tcaccccaaa gtgtggggca ccaagcctgt gtgtgctcct     1980

agaggcagca gcctgaacca gagcctgatc aaccaggacc tgacagtggc tcctggcagc     2040

acactgtggc tgtcttgcgg agttcctcca gtgcctgtgg ccaagggcag catctcttgg     2100

acacacgtgc accctagaag gcccaacgtg tccctgctgt ctctgtctct cggcggagaa     2160

catcccgtgc gcgagatgtg ggtttgggga tctcttctgc tgctgccaca ggccacagct     2220

ctggatgagg gcacctacta ctgcctgagg ggcaacctga ccatcgagag acacgtgaaa     2280

gtgatcgcca gatccgccgt gtggctctgg cttcttagaa caggcggatg gatcgtgccc     2340

gtggtcaccc tggtgtacgt gatcttctgc atggtgtccc tggtggcctt cctgtactgc     2400

cagagagcct tcatcctgag aagaaagcgc aagcggatga cctgatga                  2448


<210>  884
<211>  2271
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mCD3zICS-mCD28CS-mTWEAK-T2A-mtrCD19

<400>  884
agggccaagt tcagcaggag cgccgagacc gccgccaacc tgcaggaccc caaccagctg       60

tacaacgagc tgaacctggg caggagggag gagtacgacg tgctggagaa gaagagggcc      120

agggaccccg agatgggcgg caagcagcag aggaggagga acccccagga gggcgtgtac      180

aacgccctgc agaaggacaa gatggccgag gcctacagcg agatcggcac caagggcgag      240

aggaggaggg gcaagggcca cgacggcctg taccagggcc tgagcaccgc caccaaggac      300

acctacgacg ccctgcacat gcagaccctg gcccccagga acagcaggag gaacaggctg      360

ctgcagagcg actacatgaa catgaccccc aggaggcccg gcctgaccag gaagccctac      420

cagccctacg cccccgccag ggacttcgcc gcctacaggc ccgccgcccg tcggagccag      480

aggcggaggg ggcgccgggg ggagccgggc accgccctgc tggccccgct ggtgctgagc      540

ctgggcctgg cgctggcctg ccttggcctc ctgctggtcg tggtcagcct ggggagctgg      600

gcaacgctgt ctgcccagga gccttctcag gaggagctga cagcagagga ccgccgggag      660

ccccctgaac tgaatcccca gacagaggaa agccaggatg tggtaccttt cttggaacaa      720

ctagtccggc ctcgaagaag tgctcctaaa ggccggaagg cgcggcctcg ccgagctatt      780

gcagcccatt atgaggttca tcctcggcca ggacaggatg gagcacaagc aggtgtggat      840

gggacagtga gtggctggga agagaccaaa atcaacagct ccagccctct gcgctacgac      900

cgccagattg gggaatttac agtcatcagg gctgggctct actacctgta ctgtcaggtg      960

cactttgatg agggaaaggc tgtctacctg aagctggact tgctggtgaa cggtgtgctg     1020

gccctgcgct gcctggaaga attctcagcc acagcagcaa gctctcctgg gccccagctc     1080

cgtttgtgcc aggtgtctgg gctgttgccg ctgcggccag ggtcttccct tcggatccgc     1140

accctcccct gggctcatct taaggctgcc cccttcctaa cctactttgg actctttcaa     1200

gttcactgag ccagggccaa aaggtctggc tccggtgagg gcagaggaag tcttctaaca     1260

tgcggtgacg tggaggagaa tcccggccct atgccatctc ctctgcctgt gtccttcctg     1320

ctgttcctga cactcgtcgg cggcagacct cagaagtctc tgctggttga ggtggaagag     1380

ggcggcaatg tggtgctgcc ttgtctgcct gatagcagcc ctgtgtccag cgagaagctg     1440

gcttggtaca gaggcaacca gagcacccca tttctggaac tgagccctgg ctctcctgga     1500

ctgggactgc atgttggatc tctgggcatc ctgctggtca tcgtgaacgt gtccgatcac     1560

atgggcggct tctacctgtg ccagaagagg cctccattca aggacatctg gcagcctgcc     1620

tggaccgtga acgttgagga tagcggcgag atgttcagat ggaacgccag cgacgtgcgc     1680

gacctggact gtgacctgag aaacagaagc agcggcagcc acagaagcac ctctggctct     1740

cagctgtacg tgtgggccaa agatcacccc aaagtgtggg gcaccaagcc tgtgtgtgct     1800

cctagaggca gcagcctgaa ccagagcctg atcaaccagg acctgacagt ggctcctggc     1860

agcacactgt ggctgtcttg cggagttcct ccagtgcctg tggccaaggg cagcatctct     1920

tggacacacg tgcaccctag aaggcccaac gtgtccctgc tgtctctgtc tctcggcgga     1980

gaacatcccg tgcgcgagat gtgggtttgg ggatctcttc tgctgctgcc acaggccaca     2040

gctctggatg agggcaccta ctactgcctg aggggcaacc tgaccatcga gagacacgtg     2100

aaagtgatcg ccagatccgc cgtgtggctc tggcttctta gaacaggcgg atggatcgtg     2160

cccgtggtca ccctggtgta cgtgatcttc tgcatggtgt ccctggtggc cttcctgtac     2220

tgccagagag ccttcatcct gagaagaaag cgcaagcgga tgacctgatg a              2271


