                               SEQUENCE LISTING

<110> THE CHILDREN'S MEDICAL CENTER CORPORATION 
 
<120> OSTEOPONTIN AS A TREATMENT FOR NEURONAL LESIONS

<130> 701039-088710WOPT

<140> PCT/US2018/046436
<141> 2018-08-13

<150> 62/545,772
<151> 2017-08-15

<160> 10    

<170> PatentIn version 3.5

<210> 1
<211> 294
<212> PRT
<213> Mus musculus

<400> 1
Met Arg Leu Ala Val Ile Cys Phe Cys Leu Phe Gly Ile Ala Ser Ser 
1               5                   10                  15      


Leu Pro Val Lys Val Thr Asp Ser Gly Ser Ser Glu Glu Lys Leu Tyr 
            20                  25                  30          


Ser Leu His Pro Asp Pro Ile Ala Thr Trp Leu Val Pro Asp Pro Ser 
        35                  40                  45              


Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu Glu 
    50                  55                  60                  


Lys Asp Asp Phe Lys Gln Glu Thr Leu Pro Ser Asn Ser Asn Glu Ser 
65                  70                  75                  80  


His Asp His Met Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Gly Asp 
                85                  90                  95      


His Ala Glu Ser Glu Asp Ser Val Asp Ser Asp Glu Ser Asp Glu Ser 
            100                 105                 110         


His His Ser Asp Glu Ser Asp Glu Thr Val Thr Ala Ser Thr Gln Ala 
        115                 120                 125             


Asp Thr Phe Thr Pro Ile Val Pro Thr Val Asp Val Pro Asn Gly Arg 
    130                 135                 140                 


Gly Asp Ser Leu Ala Tyr Gly Leu Arg Ser Lys Ser Arg Ser Phe Gln 
145                 150                 155                 160 


Val Ser Asp Glu Gln Tyr Pro Asp Ala Thr Asp Glu Asp Leu Thr Ser 
                165                 170                 175     


His Met Lys Ser Gly Glu Ser Lys Glu Ser Leu Asp Val Ile Pro Val 
            180                 185                 190         


Ala Gln Leu Leu Ser Met Pro Ser Asp Gln Asp Asn Asn Gly Lys Gly 
        195                 200                 205             


Ser His Glu Ser Ser Gln Leu Asp Glu Pro Ser Leu Glu Thr His Arg 
    210                 215                 220                 


Leu Glu His Ser Lys Glu Ser Gln Glu Ser Ala Asp Gln Ser Asp Val 
225                 230                 235                 240 


Ile Asp Ser Gln Ala Ser Ser Lys Ala Ser Leu Glu His Gln Ser His 
                245                 250                 255     


Lys Phe His Ser His Lys Asp Lys Leu Val Leu Asp Pro Lys Ser Lys 
            260                 265                 270         


Glu Asp Asp Arg Tyr Leu Lys Phe Arg Ile Ser His Glu Leu Glu Ser 
        275                 280                 285             


Ser Ser Ser Glu Val Asn 
    290                 


<210> 2
<211> 314
<212> PRT
<213> Homo sapiens

<400> 2
Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              


Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 
    50                  55                  60                  


Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 
65                  70                  75                  80  


Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His 
                85                  90                  95      


Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp 
            100                 105                 110         


Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu 
        115                 120                 125             


Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu 
    130                 135                 140                 


Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly 
145                 150                 155                 160 


Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg 
                165                 170                 175     


Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser His 
            180                 185                 190         


Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala 
        195                 200                 205             


Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser 
    210                 215                 220                 


Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His Ser His 
225                 230                 235                 240 


Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu 
                245                 250                 255     


His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser Arg Glu 
            260                 265                 270         


Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val Val Asp 
        275                 280                 285             


Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile Ser His 
    290                 295                 300                 


Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
305                 310                 


<210> 3
<211> 204
<212> PRT
<213> Mus musculus

<400> 3
Met Arg Leu Ala Val Ile Cys Phe Cys Leu Phe Gly Ile Ala Ser Ser 
1               5                   10                  15      


Leu Pro Val Lys Val Thr Asp Ser Gly Ser Ser Glu Glu Lys Leu Tyr 
            20                  25                  30          


Ser Leu His Pro Asp Pro Ile Ala Thr Trp Leu Val Pro Asp Pro Ser 
        35                  40                  45              


Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu Glu 
    50                  55                  60                  


Lys Asp Asp Phe Lys Gln Glu Thr Leu Pro Ser Asn Ser Asn Glu Ser 
65                  70                  75                  80  


His Asp His Met Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Gly Asp 
                85                  90                  95      


His Ala Glu Ser Glu Asp Ser Val Asp Ser Asp Glu Ser Asp Glu Ser 
            100                 105                 110         


His His Ser Asp Glu Ser Asp Glu Thr Val Thr Ala Ser Thr Gln Ala 
        115                 120                 125             


Asp Thr Phe Thr Pro Ile Val Pro Thr Val Asp Val Pro Asn Gly Arg 
    130                 135                 140                 


Gly Asp Ser Leu Ala Tyr Gly Leu Arg Ser Lys Ser Arg Ser Phe Gln 
145                 150                 155                 160 


Val Ser Asp Glu Gln Tyr Pro Asp Ala Thr Asp Glu Asp Leu Thr Ser 
                165                 170                 175     


His Met Lys Ser Gly Glu Ser Lys Glu Ser Leu Asp Val Ile Pro Val 
            180                 185                 190         


Ala Gln Leu Leu Ser Met Pro Ser Asp Gln Asp Asn 
        195                 200                 


<210> 4
<211> 219
<212> PRT
<213> Homo sapiens

<400> 4
Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              


Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 
    50                  55                  60                  


Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 
65                  70                  75                  80  


Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His 
                85                  90                  95      


Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp 
            100                 105                 110         


Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu 
        115                 120                 125             


Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu 
    130                 135                 140                 


Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly 
145                 150                 155                 160 


Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg 
                165                 170                 175     


Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser His 
            180                 185                 190         


Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala 
        195                 200                 205             


Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser 
    210                 215                 


<210> 5
<211> 188
<212> PRT
<213> Mus musculus

<400> 5
Leu Pro Val Lys Val Thr Asp Ser Gly Ser Ser Glu Glu Lys Leu Tyr 
1               5                   10                  15      


Ser Leu His Pro Asp Pro Ile Ala Thr Trp Leu Val Pro Asp Pro Ser 
            20                  25                  30          


Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu Glu 
        35                  40                  45              


Lys Asp Asp Phe Lys Gln Glu Thr Leu Pro Ser Asn Ser Asn Glu Ser 
    50                  55                  60                  


His Asp His Met Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Gly Asp 
65                  70                  75                  80  


His Ala Glu Ser Glu Asp Ser Val Asp Ser Asp Glu Ser Asp Glu Ser 
                85                  90                  95      


His His Ser Asp Glu Ser Asp Glu Thr Val Thr Ala Ser Thr Gln Ala 
            100                 105                 110         


Asp Thr Phe Thr Pro Ile Val Pro Thr Val Asp Val Pro Asn Gly Arg 
        115                 120                 125             


Gly Asp Ser Leu Ala Tyr Gly Leu Arg Ser Lys Ser Arg Ser Phe Gln 
    130                 135                 140                 


Val Ser Asp Glu Gln Tyr Pro Asp Ala Thr Asp Glu Asp Leu Thr Ser 
145                 150                 155                 160 


His Met Lys Ser Gly Glu Ser Lys Glu Ser Leu Asp Val Ile Pro Val 
                165                 170                 175     


Ala Gln Leu Leu Ser Met Pro Ser Asp Gln Asp Asn 
            180                 185             


<210> 6
<211> 203
<212> PRT
<213> Homo sapiens

<400> 6
Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
1               5                   10                  15      


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
            20                  25                  30          


Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 
        35                  40                  45              


Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 
    50                  55                  60                  


Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His 
65                  70                  75                  80  


Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp 
                85                  90                  95      


Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu 
            100                 105                 110         


Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu 
        115                 120                 125             


Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly 
    130                 135                 140                 


Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg 
145                 150                 155                 160 


Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser His 
                165                 170                 175     


Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala 
            180                 185                 190         


Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser 
        195                 200             


<210> 7
<211> 925
<212> DNA
<213> Homo sapiens

<400> 7
atgagaattg cagtgatttg cttttgcctc ctaggcatca cctgtgccat accagttaaa       60

caggctgatt ctggaagttc tgaggaaaag cagctttaca acaaataccc agatgctgtg      120

gccacatggc taaaccctga cccatctcag aagcagaatc tcctagcccc acagaatgct      180

gtgtcctctg aagaaaccaa tgactttaaa caagagaccc ttccaagtaa gtccaacgaa      240

agccatgacc acatggatga tatggatgat gaagatgatg atgaccatgt ggacagccag      300

gactccattg actcgaacga ctctgatgat gtagatgaca ctgatgattc tcaccagtct      360

gatgagtctc accattctga tgaatctgat gaactggtca ctgattttcc cacggacctg      420

ccagcaaccg aagttttgtc cccacagtag acacatatga tggccgaggt gatagtgtgg      480

tttatggact gaggtcaaaa tctaagaagt ttcgcagacc tgacatccag taccctgatg      540

ctacagacga ggacatcacc tcacacatgg aaagcgagga gttgaatggt gcatacaagg      600

ccatccccgt tgcccaggac ctgaacgcgc cttctgattg ggacagccgt gggaaggaca      660

gttatagctg gatgaccaga gtgctgaaac ccacagccac aagcagtcca gattatataa      720

gcggaaagcc aatgatgaga gcaatgagca ttccgatgtg attgatagtc aggaactttc      780

caaagtcagc cgtgaattcc acagccatga atttcacagc catgaagata tgctggttgt      840

agaccccaaa agtaaggaag aagataaaca cctgaaattt cgtatttctc atgaattaga      900

tagtgcatct tctgaggtca attaa                                            925


<210> 8
<211> 885
<212> DNA
<213> Mus musculus

<400> 8
atgagattgg cagtgatttg cttttgcctg tttggcattg cctcctccct cccggtgaaa       60

gtgactgatt ctggcagctc agaggagaag ctttacagcc tgcacccaga tcctatagcc      120

acatggctgg tgcctgaccc atctcagaag cagaatctcc ttgcgccaca gaatgctgtg      180

tcctctgaag aaaaggatga ctttaagcaa gaaactcttc caagcaattc caatgaaagc      240

catgaccaca tggacgacga tgatgacgat gatgatgacg atggagacca tgcagagagc      300

gaggattctg tggactcgga tgaatctgac gaatctcacc attcggatga gtctgatgag      360

accgtcactg ctagtacaca agcagacact ttcactccaa tcgtccctac agtcgatgtc      420

cccaacggcc gaggtgatag cttggcttat ggactgaggt caaagtctag gagtttccag      480

gtttctgatg aacagtatcc tgatgccaca gatgaggacc tcacctctca catgaagagc      540

ggtgagtcta aggagtccct cgatgtcatc cctgttgccc agcttctgag catgccctct      600

gatcaggaca acaacggaaa gggcagccat gagtcaagtc agctggatga accaagtctg      660

gaaacacaca gacttgagca ttccaaagag agccaggaga gtgccgatca gtcggatgtg      720

atcgatagtc aagcaagttc caaagccagc ctggaacatc agagccacaa gtttcacagc      780

cacaaggaca agctagtcct agaccctaag agtaaggaag atgataggta tctgaaattc      840

cgaatttctc atgaattaga gagttcatct tctgaggtca actaa                      885


<210> 9
<211> 294
<212> PRT
<213> Mus musculus

<400> 9
Met Arg Leu Ala Val Ile Cys Phe Cys Leu Phe Gly Ile Ala Ser Ser 
1               5                   10                  15      


Leu Pro Val Lys Val Thr Asp Ser Gly Ser Ser Glu Glu Lys Leu Tyr 
            20                  25                  30          


Ser Leu His Pro Asp Pro Ile Ala Thr Trp Leu Val Pro Asp Pro Ser 
        35                  40                  45              


Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu Glu 
    50                  55                  60                  


Lys Asp Asp Phe Lys Gln Glu Thr Leu Pro Ser Asn Ser Asn Glu Ser 
65                  70                  75                  80  


His Asp His Met Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Gly Asp 
                85                  90                  95      


His Ala Glu Ser Glu Asp Ser Val Asp Ser Asp Glu Ser Asp Glu Ser 
            100                 105                 110         


His His Ser Asp Glu Ser Asp Glu Thr Val Thr Ala Ser Thr Gln Ala 
        115                 120                 125             


Asp Thr Phe Thr Pro Ile Val Pro Thr Val Asp Val Pro Asn Gly Arg 
    130                 135                 140                 


Gly Asp Ser Leu Ala Tyr Gly Leu Arg Ser Lys Ser Arg Ser Phe Gln 
145                 150                 155                 160 


Val Ser Asp Glu Gln Tyr Pro Asp Ala Thr Asp Glu Asp Leu Thr Ser 
                165                 170                 175     


His Met Lys Ser Gly Glu Ser Lys Glu Ser Leu Asp Val Ile Pro Val 
            180                 185                 190         


Ala Gln Leu Leu Ser Met Pro Ser Asp Gln Asp Asn Asn Gly Lys Gly 
        195                 200                 205             


Ser His Glu Ser Ser Gln Leu Asp Glu Pro Ser Leu Glu Thr His Arg 
    210                 215                 220                 


Leu Glu His Ser Lys Glu Ser Gln Glu Ser Ala Asp Gln Ser Asp Val 
225                 230                 235                 240 


Ile Asp Ser Gln Ala Ser Ser Lys Ala Ser Leu Glu His Gln Ser His 
                245                 250                 255     


Lys Phe His Ser His Lys Asp Lys Leu Val Leu Asp Pro Lys Ser Lys 
            260                 265                 270         


Glu Asp Asp Arg Tyr Leu Lys Phe Arg Ile Ser His Glu Leu Glu Ser 
        275                 280                 285             


Ser Ser Ser Glu Val Asn 
    290                 


<210> 10
<211> 314
<212> PRT
<213> Homo sapiens

<400> 10
Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              


Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 
    50                  55                  60                  


Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 
65                  70                  75                  80  


Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His 
                85                  90                  95      


Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp 
            100                 105                 110         


Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu 
        115                 120                 125             


Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu 
    130                 135                 140                 


Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly 
145                 150                 155                 160 


Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg 
                165                 170                 175     


Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser His 
            180                 185                 190         


Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala 
        195                 200                 205             


Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser 
    210                 215                 220                 


Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His Ser His 
225                 230                 235                 240 


Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu 
                245                 250                 255     


His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser Arg Glu 
            260                 265                 270         


Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val Val Asp 
        275                 280                 285             


Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile Ser His 
    290                 295                 300                 


Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
305                 310                 


