                         SEQUENCE LISTING

<110>  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
 
<120>  CARDIAC REPAIR BY REPROGRAMMING OF ADULT CARDIAC FIBROBLASTS INTO
        CARDIOMYOCYTES

<130>  UTFD.P3268WO

<140>  Unknown
<141>  2018-06-04

<150>  US 62/545,700
<151>  2017-08-15

<160>  60    

<170>  PatentIn version 3.5

<210>  1
<211>  3921
<212>  DNA
<213>  Homo sapiens

<400>  1
catgccttat gcaagagacc tcagtccccc ggaacaactc gatttccttc caatagaggt       60

ctgaggtgga ctcccacctc ccttcgtgaa gagttccctc ctctccccct tcctaagaaa      120

gtcgatcttg gctctatttg tgtcttatgt tcatcaccct cattcctccg gagaaagccg      180

ggttggttta tgtctttatt tattcccggg gccaagacgt ccggaacctg tggctgcgca      240

gacccggcac tgataggcga agacggagag aaatttacct cccgccgctg ccccccagcc      300

aaacgtgaca gcgcgcgggc cggttgcgtg actcgtgacg tctccaagtc ctataggtgc      360

agcggctggt gagatagtcg ctatcgcctg gttgcctctt tattttactg gggtatgcct      420

ggtaataaac agtaatattt aatttgtcgg agaccacaaa ccaaccttga gctgggaggt      480

acgtgctctt cttgacagac gttggaagaa gacctggcct aaagaggtct cttttggtgg      540

tccttttcaa agtcttcacc tgagccctgc tctccagcga ggcgcactcc tggcttttgc      600

gctccaaaga agaggtggga tagttggaga gcagaacctt gcgcgggcac agggccctgg      660

gcgcaccatg gccgacgcag acgagggctt tggcctggcg cacacgcctc tggagcctga      720

cgcaaaagac ctgccctgcg attcgaaacc cgagagcgcg ctcggggccc ccagcaagtc      780

cccgtcgtcc ccgcaggccg ccttcaccca gcagggcatg gagggaatca aagtgtttct      840

ccatgaaaga gaactgtggc taaaattcca cgaagtgggc acggaaatga tcataaccaa      900

ggctggaagg cggatgtttc ccagttacaa agtgaaggtg acgggcctta atcccaaaac      960

gaagtacatt cttctcatgg acattgtacc tgccgacgat cacagataca aattcgcaga     1020

taataaatgg tctgtgacgg gcaaagctga gcccgccatg cctggccgcc tgtacgtgca     1080

cccagactcc cccgccaccg gggcgcattg gatgaggcag ctcgtctcct tccagaaact     1140

caagctcacc aacaaccacc tggacccatt tgggcatatt attctaaatt ccatgcacaa     1200

ataccagcct agattacaca tcgtgaaagc ggatgaaaat aatggatttg gctcaaaaaa     1260

tacagcgttc tgcactcacg tctttcctga gactgcgttt atagcagtga cttcctacca     1320

gaaccacaag atcacgcaat taaagattga gaataatccc tttgccaaag gatttcgggg     1380

cagtgatgac atggagctgc acagaatgtc aagaatgcaa agtaaagaat atcccgtggt     1440

ccccaggagc accgtgaggc aaaaagtggc ctccaaccac agtcctttca gcagcgagtc     1500

tcgagctctc tccacctcat ccaatttggg gtcccaatac cagtgtgaga atggtgtttc     1560

cggcccctcc caggacctcc tgcctccacc caacccatac ccactgcccc aggagcatag     1620

ccaaatttac cattgtacca agaggaaaga ggaagaatgt tccaccacag accatcccta     1680

taagaagccc tacatggaga catcacccag tgaagaagat tccttctacc gctctagcta     1740

tccacagcag cagggcctgg gtgcctccta caggacagag tcggcacagc ggcaagcttg     1800

catgtatgcc agctctgcgc cccccagcga gcctgtgccc agcctagagg acatcagctg     1860

caacacgtgg ccaagcatgc cttcctacag cagctgcacc gtcaccaccg tgcagcccat     1920

ggacaggcta ccctaccagc acttctccgc tcacttcacc tcggggcccc tggtccctcg     1980

gctggctggc atggccaacc atggctcccc acagctggga gagggaatgt tccagcacca     2040

gacctccgtg gcccaccagc ctgtggtcag gcagtgtggg cctcagactg gcctgcagtc     2100

ccctggcacc cttcagcccc ctgagttcct ctactctcat ggcgtgccaa ggactctatc     2160

ccctcatcag taccactctg tgcacggagt tggcatggtg ccagagtgga gcgacaatag     2220

ctaaagtgag gcctgcttca caacagacat ttcctagaga aagagagaga gagaggagaa     2280

agagagagaa ggagagagac agtagccaag agaaccccac ggacaagatt tttcatttca     2340

cccaatgttc acatctgcac tcaaggtcgc tggatgctga tctaatcagt agcttgaaac     2400

cacaatttta aaaatgtgac tttcttgttt tgtctcaaaa cttaaaaaaa caaacacaaa     2460

aagatgagtc ccacccccca ctaccaccac acccatcaac cagccacatt cacgctactc     2520

cccagatctc ttcccccatt ccttcttttg ggctctagaa agtcttgcct cattgagtgt     2580

ttttccctag tgcgtagttg gagtctgtcc ctgtcttggt gttaatgttg acattgttat     2640

ataataaatg ataatatatt tttttctttc aattttctta atgggaccca gtcccttatt     2700

tggggggagg tctgaggcaa gtatatttca aaatatgtac ttgcgggatt cccttcaagt     2760

aaaccatccc tgaaacctaa attcacgttt ccccttgact aagaaaagca cctacctctg     2820

ccatgtgatg tttctgaaaa gcctctgtat gtccccattt gctttggttt tgtcctgcct     2880

tctccaatat cacgtgctca gttttgcctc tacttaccca tggagtcagg ataacactga     2940

cgctccctgg catcctatct tattcagccc taccatcttg ccagctctgt ctttccagct     3000

gtctgtcgct aaaacgtggc ctatagcttc ccttccggaa agcttgcttt gaaaaactta     3060

aaaagccccc gtttacatgt aggcaggact gtgataacag tgcaagctct gtgttgacaa     3120

gagttgtgga caaaaagcca aaataaatat tcttcctgat taaaaaaatt ttttttgaaa     3180

aaaacaaggc cagccccaac cttccaaacc tccatcacca acaacccaaa ctggatgtca     3240

agcaaaatgc acaattccta cagaagaggc aagacacagt caccaatgat atctcgccaa     3300

agaaaccacg cccacaccaa tgccaacaca aaactgtgtt tactgaaagc cgaaaacagt     3360

attaaaaaaa gtgtgtaagt aaagtgttat ggtagggttc ttcagatgta atattttact     3420

ggtactattt atttataaat aggaattcta attaagtaat aacatgaaat gaaacccagc     3480

ataggagctg gccaagagct tttaatttta ttgatactca aaaccaagtt tgtgtttttt     3540

tgtttttttt tgtttttttc ctctttcgaa tgtgctttgc tttttttgat taaaaagaat     3600

tttttttttc cttttttata aacagaccct aataaagaga acagggtaag atgtgaggct     3660

gagtgtgttt aagtacgtga gagagtgtga gtgtgtttgt aagtgagtgt ccctatgcga     3720

ttatgtctct ttacgttgct aaggggggag ggtgaggatt aagtactcgt gccttatatt     3780

tgtgtgccaa ttaatgccta ataaatacca tgtgcttaaa caagtaaaaa aaaaaaaaaa     3840

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3900

aaaaaaaaaa aaaaaaaaaa a                                               3921


<210>  2
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Asp Ala Asp Glu Gly Phe Gly Leu Ala His Thr Pro Leu Glu 
1               5                   10                  15      


Pro Asp Ala Lys Asp Leu Pro Cys Asp Ser Lys Pro Glu Ser Ala Leu 
            20                  25                  30          


Gly Ala Pro Ser Lys Ser Pro Ser Ser Pro Gln Ala Ala Phe Thr Gln 
        35                  40                  45              


Gln Gly Met Glu Gly Ile Lys Val Phe Leu His Glu Arg Glu Leu Trp 
    50                  55                  60                  


Leu Lys Phe His Glu Val Gly Thr Glu Met Ile Ile Thr Lys Ala Gly 
65                  70                  75                  80  


Arg Arg Met Phe Pro Ser Tyr Lys Val Lys Val Thr Gly Leu Asn Pro 
                85                  90                  95      


Lys Thr Lys Tyr Ile Leu Leu Met Asp Ile Val Pro Ala Asp Asp His 
            100                 105                 110         


Arg Tyr Lys Phe Ala Asp Asn Lys Trp Ser Val Thr Gly Lys Ala Glu 
        115                 120                 125             


Pro Ala Met Pro Gly Arg Leu Tyr Val His Pro Asp Ser Pro Ala Thr 
    130                 135                 140                 


Gly Ala His Trp Met Arg Gln Leu Val Ser Phe Gln Lys Leu Lys Leu 
145                 150                 155                 160 


Thr Asn Asn His Leu Asp Pro Phe Gly His Ile Ile Leu Asn Ser Met 
                165                 170                 175     


His Lys Tyr Gln Pro Arg Leu His Ile Val Lys Ala Asp Glu Asn Asn 
            180                 185                 190         


Gly Phe Gly Ser Lys Asn Thr Ala Phe Cys Thr His Val Phe Pro Glu 
        195                 200                 205             


Thr Ala Phe Ile Ala Val Thr Ser Tyr Gln Asn His Lys Ile Thr Gln 
    210                 215                 220                 


Leu Lys Ile Glu Asn Asn Pro Phe Ala Lys Gly Phe Arg Gly Ser Asp 
225                 230                 235                 240 


Asp Met Glu Leu His Arg Met Ser Arg Met Gln Ser Lys Glu Tyr Pro 
                245                 250                 255     


Val Val Pro Arg Ser Thr Val Arg Gln Lys Val Ala Ser Asn His Ser 
            260                 265                 270         


Pro Phe Ser Ser Glu Ser Arg Ala Leu Ser Thr Ser Ser Asn Leu Gly 
        275                 280                 285             


Ser Gln Tyr Gln Cys Glu Asn Gly Val Ser Gly Pro Ser Gln Asp Leu 
    290                 295                 300                 


Leu Pro Pro Pro Asn Pro Tyr Pro Leu Pro Gln Glu His Ser Gln Ile 
305                 310                 315                 320 


Tyr His Cys Thr Lys Arg Lys Glu Glu Glu Cys Ser Thr Thr Asp His 
                325                 330                 335     


Pro Tyr Lys Lys Pro Tyr Met Glu Thr Ser Pro Ser Glu Glu Asp Ser 
            340                 345                 350         


Phe Tyr Arg Ser Ser Tyr Pro Gln Gln Gln Gly Leu Gly Ala Ser Tyr 
        355                 360                 365             


Arg Thr Glu Ser Ala Gln Arg Gln Ala Cys Met Tyr Ala Ser Ser Ala 
    370                 375                 380                 


Pro Pro Ser Glu Pro Val Pro Ser Leu Glu Asp Ile Ser Cys Asn Thr 
385                 390                 395                 400 


Trp Pro Ser Met Pro Ser Tyr Ser Ser Cys Thr Val Thr Thr Val Gln 
                405                 410                 415     


Pro Met Asp Arg Leu Pro Tyr Gln His Phe Ser Ala His Phe Thr Ser 
            420                 425                 430         


Gly Pro Leu Val Pro Arg Leu Ala Gly Met Ala Asn His Gly Ser Pro 
        435                 440                 445             


Gln Leu Gly Glu Gly Met Phe Gln His Gln Thr Ser Val Ala His Gln 
    450                 455                 460                 


Pro Val Val Arg Gln Cys Gly Pro Gln Thr Gly Leu Gln Ser Pro Gly 
465                 470                 475                 480 


Thr Leu Gln Pro Pro Glu Phe Leu Tyr Ser His Gly Val Pro Arg Thr 
                485                 490                 495     


Leu Ser Pro His Gln Tyr His Ser Val His Gly Val Gly Met Val Pro 
            500                 505                 510         


Glu Trp Ser Asp Asn Ser 
        515             


<210>  3
<211>  6449
<212>  DNA
<213>  Homo sapiens

<400>  3
gagctgttct ccttttccca ttcgtcttct gtcacttcct tcctggacgc agttttctgg       60

acgagtctgg ttacttttaa tccgaccggc cgctgagagc cactttctcc tcctcctcct      120

cctcctcctt ctcttcctcc tccttcttcc tcctcctcct cctcttccga gcggcctcgg      180

cgcgcgcgaa tgcgcggccc cgcgcccccc ccctcgcgcg cgctcccctc gcgcgcgcgc      240

acacacgcac acatcgtctc cagctctctg ctcgctctgc tcgcagtcac agacacttga      300

gcacacgcgt acacccagac atcttcgggc tgctattgga ttgactttga aggttctgtg      360

tgggtcgccg tggctgcatg tttgaatcag gtggagaagc acttcaacgc tggacgaagt      420

aaagattatt gttgttattt tttttttctc tctctctctc tcttaagaaa ggaaaatatc      480

ccaaggacta atctgatcgg gtcttccttc atcaggaacg aatgcaggaa tttgggaact      540

gagctgtgca agtgctgaag aaggagattt gtttggagga aacaggaaag agaaagaaaa      600

ggaaggaaaa aatacataat ttcagggacg agagagagaa gaaaaacggg gactatgggg      660

agaaaaaaga ttcagattac gaggattatg gatgaacgta acagacaggt gacatttaca      720

aagaggaaat ttgggttgat gaagaaggct tatgagctga gcgtgctgtg tgactgtgag      780

attgcgctga tcatcttcaa cagcaccaac aagctgttcc agtatgccag caccgacatg      840

gacaaagtgc ttctcaagta cacggagtac aacgagccgc atgagagccg gacaaactca      900

gacatcgtgg agacgttgag aaagaagggc cttaatggct gtgacagccc agaccccgat      960

gcggacgatt ccgtaggtca cagccctgag tctgaggaca agtacaggaa aattaacgaa     1020

gatattgatc taatgatcag caggcaaaga ttgtgtgctg ttccacctcc caacttcgag     1080

atgccagtct ccatcccagt gtccagccac aacagtttgg tgtacagcaa ccctgtcagc     1140

tcactgggaa accccaacct attgccactg gctcaccctt ctctgcagag gaatagtatg     1200

tctcctggtg taacacatcg acctccaagt gcaggtaaca caggtggtct gatgggtgga     1260

gacctcacgt ctggtgcagg caccagtgca gggaacgggt atggcaatcc ccgaaactca     1320

ccaggtctgc tggtctcacc tggtaacttg aacaagaata tgcaagcaaa atctcctccc     1380

ccaatgaatt taggaatgaa taaccgtaaa ccagatctcc gagttcttat tccaccaggc     1440

agcaagaata cgatgccatc agtgtctgag gatgtcgacc tgcttttgaa tcaaaggata     1500

aataactccc agtcggctca gtcattggct accccagtgg tttccgtagc aactcctact     1560

ttaccaggac aaggaatggg aggatatcca tcagccattt caacaacata tggtaccgag     1620

tactctctga gtagtgcaga cctgtcatct ctgtctgggt ttaacaccgc cagcgctctt     1680

caccttggtt cagtaactgg ctggcaacag caacacctac ataacatgcc accatctgcc     1740

ctcagtcagt tgggagcttg cactagcact catttatctc agagttcaaa tctctccctg     1800

ccttctactc aaagcctcaa catcaagtca gaacctgttt ctcctcctag agaccgtacc     1860

accacccctt cgagataccc acaacacacg cgccacgagg cggggagatc tcctgttgac     1920

agcttgagca gctgtagcag ttcgtacgac gggagcgacc gagaggatca ccggaacgaa     1980

ttccactccc ccattggact caccagacct tcgccggacg aaagggaaag tccctcagtc     2040

aagcgcatgc gactttctga aggatgggca acatgatcag attattactt actagttttt     2100

ttttttttct tgcagtgtgt gtgtgtgcta taccttaatg gggaaggggg gtcgatatgc     2160

attatatgtg ccgtgtgtgg aaaaaaaaaa agtcaggtac tctgttttgt aaaagtactt     2220

ttaaattgcc tcagtgatac agtataaaga taaacagaaa tgctgagata agcttagcac     2280

ttgagttgta caacagaaca cttgtacaaa atagatttta aggctaactt cttttcactg     2340

ttgtgctcct ttgcaaaatg tatgttacaa tagatagtgt catgttgcag gttcaacgtt     2400

atttacatgt aaatagacaa aaggaaacat ttgccaaaag cggcagatct ttactgaaag     2460

agagagcagc tgttatgcaa catatagaaa aatgtataga tgcttggaca gacccggtaa     2520

tgggtggcca ttggtaaatg ttaggaacac accaggtcac ctgacatccc aagaatgctc     2580

acaaacctgc aggcatatca ttggcgtatg gcactcatta aaaaggatca gagaccatta     2640

aaagaggacc atacctatta aaaaaaaatg tggagttgga gggctaacat atttaattaa     2700

ataaataaat aaatctgggt ctgcatctct tattaaataa aaatataaaa atatgtacat     2760

tacattttgc ttattttcat ataaaaggta agacagagtt tgcaaagcat ttgtggcttt     2820

ttgtagttta cttaagccaa aatgtgtttt tttccccttg atagcttcgc taatatttta     2880

aacagtcctg taaaaaacca aaaaggactt tttgtataga aagcactacc ctaagccatg     2940

aagaactcca tgctttgcta accaagataa ctgttttctc tttgtagaag ttttgttttt     3000

gaaatgtgta tttctaatta tataaaatat taagaatctt ttaaaaaaat ctgtgaaatt     3060

aacatgcttg tgtatagctt tctaatatat ataatattat ggtaatagca gaagttttgt     3120

tatcttaata gcgggagggg ggtatatttg tgcagttgca catttgagta actattttct     3180

ttctgttttc ttttactctg cttacatttt ataagtttaa ggtcagctgt caaaaggata     3240

acctgtgggg ttagaacata tcacattgca acaccctaaa ttgtttttaa tacattagca     3300

atctattggg tcaactgaca tccattgtat atactagttt ctttcatgct atttttattt     3360

tgttttttgc atttttatca aatgcagggc ccctttctga tctcaccatt tcaccatgca     3420

tcttggaatt cagtaagtgc atatcctaac ttgcccatat tctaaatcat ctggttggtt     3480

ttcagcctag aatttgatac gctttttaga aatatgccca gaatagaaaa gctatgttgg     3540

ggcacatgtc ctgcaaatat ggccctagaa acaagtgata tggaatttac ttggtgaata     3600

agttataaat tcccacagaa gaaaaatgtg aaagactggg tgctagacaa gaaggaagca     3660

ggtaaaggga tagttgcttt gtcatccgtt tttaattatt ttaactgacc cttgacaatc     3720

ttgtcagcaa tataggactg ttgaacaatc ccggtgtgtc aggaccccca aatgtcactt     3780

ctgcataaag catgtatgtc atctattttt tcttcaataa agagatttaa tagccatttc     3840

aagaaatccc ataaagaacc tctctatgtc ccttttttta atttaaaaaa aatgactctt     3900

gtctaatatt cgtctataag ggattaattt tcagaccctt taataagtga gtgccataag     3960

aaagtcaata tatattgttt aaaagatatt tcagtctagg aaagattttc cttctcttgg     4020

aatgtgaaga tctgtcgatt catctccaat catatgcatt gacatacaca gcaaagaaga     4080

tataggcagt aatatcaaca ctgctatatc atgtgtagga catttcttat ccattttttc     4140

tcttttactt gcatagttgc tatgtgtttc tcattgtaaa aggctgccgc tgggtggcag     4200

aagccaagag accttattaa ctaggctata tttttcttaa cttgatctga aatccacaat     4260

tagaccacaa tgcacctttg gttgtatcca taaaggatgc tagcctgcct tgtactaatg     4320

ttttatatat taaaaaaaaa aaatctatca accatttcat atatatccca ctactcaagg     4380

tatccatgga acatgaaaga ataacattta tgcagaggaa aaacaaaaac atccctgaaa     4440

atatacacac tcatacacac acacgcacag gggaataaaa taagaaaatc attttcctca     4500

ccatagactt gatcccatcc ttacaaccca tccttctaac ttgatgtgta taaaatatgc     4560

aaacatttca caaatgttct ttgtcatttc aaaatacttt agtatatcaa tatcagtaga     4620

taccagtggg tgggaaaggg tcattacatg aaaatatgaa gaaatagcca tattagtttt     4680

ttaacctgca atttgcctca gcaacaaaga aaaagtgaat ttttaatgct gaagataaag     4740

taagctaaag taccagcaga agccttggct atttatagca gttctgacaa tagttttata     4800

agaacatgaa gagaacagaa tcacttgaaa atggatgcca gtcatctctt gttcccacta     4860

ctgaattctt ataaagtggt ggcaagatag ggaagggata atctgagaat ttttaaaaga     4920

tgatttaatg agaagaagca caattttgat tttgatgagt cactttctgt aaacaatctt     4980

ggtctatctt tacccttata ccttatctgt aatttaccat ttattgtatt tgcaaagcta     5040

gtatggtttt taatcacagt aaatcctttg tattccagac tttagggcag agccctgagg     5100

gagtattatt ttacataacc cgtcctagag taacatttta ggcaacattc ttcattgcaa     5160

gtaaaagatc cataagtggc attttacacg gctgcgagta ttgttatatc taatcctatt     5220

ttaaaagatt tttggtaata tgaagcttga atactggtaa cagtgatgca atatacgcaa     5280

gctgcacaac ctgtatattg tatgcattgc tgcgtggagg ctgtttattt caaccttttt     5340

aaaaattgtg ttttttagta aaatggctta ttttttccca aaggtggaat ttagcatttt     5400

gtaatgatga atataaaaat acctgtcatc cccagatcat ttaaaagtta actaaagtga     5460

gaatgaaaaa acaaaattcc aagacacttt ttaaaagaat gtctgccctc acacactttt     5520

atggatttgt ttttcttaca tacccatctt ttaacttaga gatagcattt tttgccctct     5580

ttattttgtt gtttgtttct ccagagagta aacgctttgt agttctttct ttaaaaaaca     5640

ttttttttaa agaagaagaa gccacttgaa ccctcaataa aggctgttgc ctaagcatgg     5700

catacttcat ctgttctcat ttgtgccatc tgccgtgatg tcgtcacttt tatggcgtta     5760

atttcctgcc actacagatc ttttgaagat tgctggaata ctggtgtctg ttagaatgct     5820

tcagactaca gatgtaatta aaggcttttc ttaatatgtt ttaaccaaag atgtggagca     5880

atccaagcca catatcttct acatcaaatt tttccatttt ggttattttc ataatctggt     5940

attgcatttt gccttccctg ttcatacctc aaattgattc atacctcagt ttaattcaga     6000

gaggtcagtt aagtgacgga ttctgttgtg gtttgaatgc agtaccagtg ttctcttcga     6060

gcaaagtaga cctgggtcac tgtaggcata ggacttggat tgcttcagat ggtttgctgt     6120

atcatttttc ttctttttct tttcctgggg acttgtttcc attaaatgag agtaattaaa     6180

atcgcttgta aatgagggca tacaagcatt tgcaacaaat attcaaatag aggctcacag     6240

cggcataagc tggactttgt cgccactaga tgacaagatg ttataactaa gttaaaccac     6300

atctgtgtat ctcaagggac ttaattcagc tgtctgtagt gaataaaagt gggaaatttt     6360

caaaagtttc tcctgctgga aataaggtat aatttgtatt ttgcagacaa ttcagtaaag     6420

ttactggctt tcttagtgaa aaaaaaaaa                                       6449


<210>  4
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Arg Lys Lys Ile Gln Ile Thr Arg Ile Met Asp Glu Arg Asn 
1               5                   10                  15      


Arg Gln Val Thr Phe Thr Lys Arg Lys Phe Gly Leu Met Lys Lys Ala 
            20                  25                  30          


Tyr Glu Leu Ser Val Leu Cys Asp Cys Glu Ile Ala Leu Ile Ile Phe 
        35                  40                  45              


Asn Ser Thr Asn Lys Leu Phe Gln Tyr Ala Ser Thr Asp Met Asp Lys 
    50                  55                  60                  


Val Leu Leu Lys Tyr Thr Glu Tyr Asn Glu Pro His Glu Ser Arg Thr 
65                  70                  75                  80  


Asn Ser Asp Ile Val Glu Thr Leu Arg Lys Lys Gly Leu Asn Gly Cys 
                85                  90                  95      


Asp Ser Pro Asp Pro Asp Ala Asp Asp Ser Val Gly His Ser Pro Glu 
            100                 105                 110         


Ser Glu Asp Lys Tyr Arg Lys Ile Asn Glu Asp Ile Asp Leu Met Ile 
        115                 120                 125             


Ser Arg Gln Arg Leu Cys Ala Val Pro Pro Pro Asn Phe Glu Met Pro 
    130                 135                 140                 


Val Ser Ile Pro Val Ser Ser His Asn Ser Leu Val Tyr Ser Asn Pro 
145                 150                 155                 160 


Val Ser Ser Leu Gly Asn Pro Asn Leu Leu Pro Leu Ala His Pro Ser 
                165                 170                 175     


Leu Gln Arg Asn Ser Met Ser Pro Gly Val Thr His Arg Pro Pro Ser 
            180                 185                 190         


Ala Gly Asn Thr Gly Gly Leu Met Gly Gly Asp Leu Thr Ser Gly Ala 
        195                 200                 205             


Gly Thr Ser Ala Gly Asn Gly Tyr Gly Asn Pro Arg Asn Ser Pro Gly 
    210                 215                 220                 


Leu Leu Val Ser Pro Gly Asn Leu Asn Lys Asn Met Gln Ala Lys Ser 
225                 230                 235                 240 


Pro Pro Pro Met Asn Leu Gly Met Asn Asn Arg Lys Pro Asp Leu Arg 
                245                 250                 255     


Val Leu Ile Pro Pro Gly Ser Lys Asn Thr Met Pro Ser Val Ser Glu 
            260                 265                 270         


Asp Val Asp Leu Leu Leu Asn Gln Arg Ile Asn Asn Ser Gln Ser Ala 
        275                 280                 285             


Gln Ser Leu Ala Thr Pro Val Val Ser Val Ala Thr Pro Thr Leu Pro 
    290                 295                 300                 


Gly Gln Gly Met Gly Gly Tyr Pro Ser Ala Ile Ser Thr Thr Tyr Gly 
305                 310                 315                 320 


Thr Glu Tyr Ser Leu Ser Ser Ala Asp Leu Ser Ser Leu Ser Gly Phe 
                325                 330                 335     


Asn Thr Ala Ser Ala Leu His Leu Gly Ser Val Thr Gly Trp Gln Gln 
            340                 345                 350         


Gln His Leu His Asn Met Pro Pro Ser Ala Leu Ser Gln Leu Gly Ala 
        355                 360                 365             


Cys Thr Ser Thr His Leu Ser Gln Ser Ser Asn Leu Ser Leu Pro Ser 
    370                 375                 380                 


Thr Gln Ser Leu Asn Ile Lys Ser Glu Pro Val Ser Pro Pro Arg Asp 
385                 390                 395                 400 


Arg Thr Thr Thr Pro Ser Arg Tyr Pro Gln His Thr Arg His Glu Ala 
                405                 410                 415     


Gly Arg Ser Pro Val Asp Ser Leu Ser Ser Cys Ser Ser Ser Tyr Asp 
            420                 425                 430         


Gly Ser Asp Arg Glu Asp His Arg Asn Glu Phe His Ser Pro Ile Gly 
        435                 440                 445             


Leu Thr Arg Pro Ser Pro Asp Glu Arg Glu Ser Pro Ser Val Lys Arg 
    450                 455                 460                 


Met Arg Leu Ser Glu Gly Trp Ala Thr 
465                 470             


<210>  5
<211>  3473
<212>  DNA
<213>  Homo sapiens

<400>  5
agtcagcgcc ctagggccga gttgctgggc cggggacccg agccgcgagc tggggacttg       60

gaggcggccg gcgcaggggc cgcgagaggc ttcgtcgccg ctgcagctcc gggggctccc      120

aggggagcgt gcgcggaacc tccaggccca gcaggacccc ggctgcggcg aggaggaagg      180

agccagccta gcagcttctg cgcctgtggc cgcgggtgtc ctggaggcct ctcggtgtga      240

cgagtggggg acccgaaggc tcgtgcgcca cctccaggcc tggacgctgc cctccgtctt      300

ctgcccccaa taggtgcgcc ggaccttcag gccctggggt gaattcagct gctcctacat      360

cagcttccgg aaccaccaaa aattcaaatt gggattttcc ggagtaaaca agagcctaga      420

gccctttgct caatgctgga tttaatacgt atatattttt aagcgagttg gttttttccc      480

ctttgatttt tgatcttcgc gacagttcct cccacgcata ttatcgttgt tgccgtcgtt      540

ttctctcccc gcgtggctcc ttgacctgcg agggagagag aggacaccga agccgggagc      600

tcgcagggac catgtatcag agcttggcca tggccgccaa ccacgggccg ccccccggtg      660

cctacgaggc gggcggcccc ggcgccttca tgcacggcgc gggcgccgcg tcctcgccag      720

tctacgtgcc cacaccgcgg gtgccctcct ccgtgctggg cctgtcctac ctccagggcg      780

gaggcgcggg ctctgcgtcc ggaggcgcct cgggcggcag ctccggtggg gccgcgtctg      840

gtgcggggcc cgggacccag cagggcagcc cgggatggag ccaggcggga gccgacggag      900

ccgcttacac cccgccgccg gtgtcgccgc gcttctcctt cccggggacc accgggtccc      960

tggcggccgc cgccgccgct gccgcggccc gggaagctgc ggcctacagc agtggcggcg     1020

gagcggcggg tgcgggcctg gcgggccgcg agcagtacgg gcgcgccggc ttcgcgggct     1080

cctactccag cccctacccg gcttacatgg ccgacgtggg cgcgtcctgg gccgcagccg     1140

ccgccgcctc cgccggcccc ttcgacagcc cggtcctgca cagcctgccc ggccgggcca     1200

acccggccgc ccgacacccc aatctcgata tgtttgacga cttctcagaa ggcagagagt     1260

gtgtcaactg tggggctatg tccaccccgc tctggaggcg agatgggacg ggtcactatc     1320

tgtgcaacgc ctgcggcctc taccacaaga tgaacggcat caaccggccg ctcatcaagc     1380

ctcagcgccg gctgtccgcc tcccgccgag tgggcctctc ctgtgccaac tgccagacca     1440

ccaccaccac gctgtggcgc cgcaatgcgg agggcgagcc tgtgtgcaat gcctgcggcc     1500

tctacatgaa gctccacggg gtccccaggc ctcttgcaat gcggaaagag gggatccaaa     1560

ccagaaaacg gaagcccaag aacctgaata aatctaagac accagcagct ccttcaggca     1620

gtgagagcct tcctcccgcc agcggtgctt ccagcaactc cagcaacgcc accaccagca     1680

gcagcgagga gatgcgtccc atcaagacgg agcctggcct gtcatctcac tacgggcaca     1740

gcagctccgt gtcccagacg ttctcagtca gtgcgatgtc tggccatggg ccctccatcc     1800

accctgtcct ctcggccctg aagctctccc cacaaggcta tgcgtctccc gtcagccagt     1860

ctccacagac cagctccaag caggactctt ggaacagcct ggtcttggcc gacagtcacg     1920

gggacataat cactgcgtaa tcttccctct tccctcctca aattcctgca cggacctggg     1980

acttggagga tagcaaagaa ggaggccctg ggctcccagg ggccggcctc ctctgcctgg     2040

taatgactcc agaacaacaa ctgggaagaa acttgaagtc gacaatctgg ttaggggaag     2100

cgggtgttgg attttctcag atgcctttac acgctgatgg gactggaggg agcccaccct     2160

tcagcacgag cacactgcat ctctcctgtg agttggagac ttctttccca agatgtcctt     2220

gtcccctgcg ttccccactg tggcctagac cgtgggtttt gcattgtgtt tctagcaccg     2280

aggatctgag aacaagcgga gggccgggcc ctgggacccc tgctccagcc cgaatgacgg     2340

catctgtttg ccatgtacct ggatgcgacg ggcccctggg gacaggccct tgccccatcc     2400

atccgcttga ggcatggcac cgccctgcat ccctaatacc aaatctgact ccaaaattgt     2460

ggggtgtgac atacaagtga ctgaacactt cctggggagc tacaggggca cttaacccac     2520

cacagcacag cctcatcaaa atgcagctgg caacttctcc cccaggtgcc ttccccctgc     2580

tgccggcctt tgctccttca cttccaacat ctctcaaaat aaaaatccct cttcccgctc     2640

tgagcgattc agctctgccc gcagcttgta catgtctctc ccctggcaaa acaagagctg     2700

ggtagtttag ccaaacggca ccccctcgag ttcactgcag acccttcgtt caccgtgtca     2760

cacatagagg ggttctgagt aagaacaaaa cgttctgctg ctcaagccag tctggcaagc     2820

actcagccca gcctcgaggt ccttctgggg agagtgtaag tggacagagt cctggtcagg     2880

gggcaggagt gtcccaaggg ctggcccacc tgctgtctgt ctgctcctcc tagcccttgg     2940

tcagatggca gccagagtcc ctcaggacct gcagcctcgc cccggcagaa gtcttttgtc     3000

caggaggcaa aaagccagag attctgcaac acgaattcga agcaaacaaa cacaacacaa     3060

cagaattcct ggaaagaaga cgactgctaa gacacggcag gggggcctgg agggagcctc     3120

cgactctgag ctgctccggg atctgccgcg ttctcctctg cacattgctg tttctgcccc     3180

tgatgctgga gctcaaggag actccttcct ctttctcagc agagctgtag ctgactgtgg     3240

cattactacg cctccccaca cgcccagacc cctcactcca aaatcctact ggctgtagca     3300

gagaatacct ttgaaccaag attctgtttt aatcatcatt tacattgttt tcttccaaag     3360

gccccctcgt ataccctccc taacccacaa acctgttaac attgtcttaa ggtgaaatgg     3420

ctggaaaatc agtatttaac taataaattt atctgtattc ctctttcaaa aaa            3473


<210>  6
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Tyr Gln Ser Leu Ala Met Ala Ala Asn His Gly Pro Pro Pro Gly 
1               5                   10                  15      


Ala Tyr Glu Ala Gly Gly Pro Gly Ala Phe Met His Gly Ala Gly Ala 
            20                  25                  30          


Ala Ser Ser Pro Val Tyr Val Pro Thr Pro Arg Val Pro Ser Ser Val 
        35                  40                  45              


Leu Gly Leu Ser Tyr Leu Gln Gly Gly Gly Ala Gly Ser Ala Ser Gly 
    50                  55                  60                  


Gly Ala Ser Gly Gly Ser Ser Gly Gly Ala Ala Ser Gly Ala Gly Pro 
65                  70                  75                  80  


Gly Thr Gln Gln Gly Ser Pro Gly Trp Ser Gln Ala Gly Ala Asp Gly 
                85                  90                  95      


Ala Ala Tyr Thr Pro Pro Pro Val Ser Pro Arg Phe Ser Phe Pro Gly 
            100                 105                 110         


Thr Thr Gly Ser Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Arg Glu 
        115                 120                 125             


Ala Ala Ala Tyr Ser Ser Gly Gly Gly Ala Ala Gly Ala Gly Leu Ala 
    130                 135                 140                 


Gly Arg Glu Gln Tyr Gly Arg Ala Gly Phe Ala Gly Ser Tyr Ser Ser 
145                 150                 155                 160 


Pro Tyr Pro Ala Tyr Met Ala Asp Val Gly Ala Ser Trp Ala Ala Ala 
                165                 170                 175     


Ala Ala Ala Ser Ala Gly Pro Phe Asp Ser Pro Val Leu His Ser Leu 
            180                 185                 190         


Pro Gly Arg Ala Asn Pro Ala Ala Arg His Pro Asn Leu Asp Met Phe 
        195                 200                 205             


Asp Asp Phe Ser Glu Gly Arg Glu Cys Val Asn Cys Gly Ala Met Ser 
    210                 215                 220                 


Thr Pro Leu Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala 
225                 230                 235                 240 


Cys Gly Leu Tyr His Lys Met Asn Gly Ile Asn Arg Pro Leu Ile Lys 
                245                 250                 255     


Pro Gln Arg Arg Leu Ser Ala Ser Arg Arg Val Gly Leu Ser Cys Ala 
            260                 265                 270         


Asn Cys Gln Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Glu Gly 
        275                 280                 285             


Glu Pro Val Cys Asn Ala Cys Gly Leu Tyr Met Lys Leu His Gly Val 
    290                 295                 300                 


Pro Arg Pro Leu Ala Met Arg Lys Glu Gly Ile Gln Thr Arg Lys Arg 
305                 310                 315                 320 


Lys Pro Lys Asn Leu Asn Lys Ser Lys Thr Pro Ala Ala Pro Ser Gly 
                325                 330                 335     


Ser Glu Ser Leu Pro Pro Ala Ser Gly Ala Ser Ser Asn Ser Ser Asn 
            340                 345                 350         


Ala Thr Thr Ser Ser Ser Glu Glu Met Arg Pro Ile Lys Thr Glu Pro 
        355                 360                 365             


Gly Leu Ser Ser His Tyr Gly His Ser Ser Ser Val Ser Gln Thr Phe 
    370                 375                 380                 


Ser Val Ser Ala Met Ser Gly His Gly Pro Ser Ile His Pro Val Leu 
385                 390                 395                 400 


Ser Ala Leu Lys Leu Ser Pro Gln Gly Tyr Ala Ser Pro Val Ser Gln 
                405                 410                 415     


Ser Pro Gln Thr Ser Ser Lys Gln Asp Ser Trp Asn Ser Leu Val Leu 
            420                 425                 430         


Ala Asp Ser His Gly Asp Ile Ile Thr Ala 
        435                 440         


<210>  7
<211>  2368
<212>  DNA
<213>  Homo sapiens

<400>  7
ctgtacatgg agatcttgct gggaaaatcc gcttgctccc ctcacgtcgt ccagcccagg       60

agaaccaccg ccgtcacccc ggagcttcct cggccaccgc gcagagccct ccgagagccc      120

gagccgcggt cttcgagctc caaggctcat tcagggcccc agatccttgc cccgaaagga      180

gaggatctga gaaaatggat gcactgagac ctctctgaaa accctccgag agagcgcgag      240

aggagcgagg acacgttact cgcagctaaa atcacattta aggaccaaaa caacaacaac      300

caaaaatttc attaaaacaa taagcgccca agaacccaga tcgggctggt ggggggaggg      360

gaagaggcgg gaaggggagg gtcgcacgga ggtagctttg cagtgagcag tcgaccccgc      420

cgccccccgg cacagctgga ccggctcctc cagccgcggc tcagactcgc ccctggattc      480

cgggttagct tcggtgccag gaccgcggcc cgggcttgga ttcccgagac tccgcgtacc      540

agcctcgcgg gagccccggc acctttgtat gagcacgaga ggattctgcc tccgcgcagc      600

agcccgggaa gcaggagccg aagcgcgggc cgtggagcaa ggcgggaacc ggaggcggcg      660

gcggcggcgg ccaggggcgc acggtgccag gaccagctcg ccgcgcccca tggggagccg      720

gcggccgcag cgctgctgag gcgggcccgg ctggccaggc ggggggacgg ggcccgggct      780

gcagcagccc cctctgcggc tgccgggcgg gcccgggcgc ccgggggctg gggggtgggg      840

ggtgggggag gacgccgagc gctgaggcag gggcccgggc cgagggcgcg gcggggctgc      900

gcgcacgctg gggcgcgtgg aggggcgcgg agggcgaaat gagtctggta ggtggttttc      960

cccaccaccc ggtggtgcac cacgagggct acccgtttgc cgccgccgcc gccgcagctg     1020

ccgccgccgc cgccagccgc tgcagccatg aggagaaccc ctacttccat ggctggctca     1080

tcggccaccc cgagatgtcg ccccccgact acagcatggc cctgtcctac agccccgagt     1140

atgccagcgg cgccgccggc ctggaccact cccattacgg gggggtgccg ccgggcgccg     1200

ggcccccggg cctggggggg ccgcgcccgg tgaagcgccg aggcaccgcc aaccgcaagg     1260

agcggcgcag gactcagagc atcaacagcg ccttcgccga actgcgcgag tgcatcccca     1320

acgtacccgc cgacaccaaa ctctccaaaa tcaagaccct gcgcctggcc accagctaca     1380

tcgcctacct catggacctg ctggccaagg acgaccagaa tggcgaggcg gaggccttca     1440

aggcagagat caagaagacc gacgtgaaag aggagaagag gaagaaggag ctgaacgaaa     1500

tcttgaaaag cacagtgagc agcaacgaca agaaaaccaa aggccggacg ggctggccgc     1560

agcacgtctg ggccctggag ctcaagcagt gaggaggagg agaaggagga ggaggagagc     1620

gcgagtgagc aggggccaag gcgccagatg cagacccagg actccggaaa agccgtccgc     1680

gctccgctct gaggactcct tgcatttgga atcatccggt ttatttatgt gcaatttcct     1740

tcccctctct ttgaccccct ttgaggcatc tgctccccgt ctccccctcc aaaaaaaaag     1800

tggatatttg aagaaaagca ttccatattt taatacgaag aggacactcc cgtgtggtaa     1860

gggatcccgt cgtctcatag attctgtgtg cgtgaatgtt ccctcttggc tgtgtagaca     1920

ccagcgttgc cccccgccaa cctactcaac cccttccaga taaagacagt gggcactagt     1980

gcgtttgtga agtgtatctt taatacttgg cctttggata taaatattcc tgggtattat     2040

aaagttttat ttcaaagcag aaaacagggc cgctaacatt tccgttgggg tcggtatcta     2100

gtgctatcca ttcatctgtg gtcgttccct ctttgaagat gtttccaaca gccacttgtt     2160

ttgtgcactt ccgtcctcta aaactaaatg gaatttaatt aatattgaag gtgtaaacgt     2220

tgtaagtatt caataaacca ctgtgttttt tttttacaaa aaccttaatc ttttaatggc     2280

tgatacctca aaagagtttt gaaaacaaag ctgttatact tgttttcgta atatttaaaa     2340

tattcagaag taaactaaat tatcatga                                        2368


<210>  8
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser Leu Val Gly Gly Phe Pro His His Pro Val Val His His Glu 
1               5                   10                  15      


Gly Tyr Pro Phe Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
            20                  25                  30          


Ser Arg Cys Ser His Glu Glu Asn Pro Tyr Phe His Gly Trp Leu Ile 
        35                  40                  45              


Gly His Pro Glu Met Ser Pro Pro Asp Tyr Ser Met Ala Leu Ser Tyr 
    50                  55                  60                  


Ser Pro Glu Tyr Ala Ser Gly Ala Ala Gly Leu Asp His Ser His Tyr 
65                  70                  75                  80  


Gly Gly Val Pro Pro Gly Ala Gly Pro Pro Gly Leu Gly Gly Pro Arg 
                85                  90                  95      


Pro Val Lys Arg Arg Gly Thr Ala Asn Arg Lys Glu Arg Arg Arg Thr 
            100                 105                 110         


Gln Ser Ile Asn Ser Ala Phe Ala Glu Leu Arg Glu Cys Ile Pro Asn 
        115                 120                 125             


Val Pro Ala Asp Thr Lys Leu Ser Lys Ile Lys Thr Leu Arg Leu Ala 
    130                 135                 140                 


Thr Ser Tyr Ile Ala Tyr Leu Met Asp Leu Leu Ala Lys Asp Asp Gln 
145                 150                 155                 160 


Asn Gly Glu Ala Glu Ala Phe Lys Ala Glu Ile Lys Lys Thr Asp Val 
                165                 170                 175     


Lys Glu Glu Lys Arg Lys Lys Glu Leu Asn Glu Ile Leu Lys Ser Thr 
            180                 185                 190         


Val Ser Ser Asn Asp Lys Lys Thr Lys Gly Arg Thr Gly Trp Pro Gln 
        195                 200                 205             


His Val Trp Ala Leu Glu Leu Lys Gln 
    210                 215         


<210>  9
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Lys Lys Lys Arg Lys Val 
            20              


<210>  10
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  11
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Arg Arg Met Lys Trp Lys Lys 
1               5           


<210>  12
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Arg Arg Trp Arg Arg Trp Trp Arg Arg Trp Trp Arg Arg Trp Arg Arg 
1               5                   10                  15      


<210>  13
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Arg Gly Gly Arg Leu Ser Tyr Ser Arg Arg Arg Phe Ser Thr Ser Thr 
1               5                   10                  15      


Gly Arg 
        


<210>  14
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  15
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  16
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  17
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Arg Arg Arg Arg Arg Arg Arg Arg 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Lys Lys Lys Lys Lys Lys Lys Lys 
1               5               


<210>  19
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Xaa Ile Leu 
            20                  25          


<210>  20
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Leu Leu Ile Leu Leu Arg Arg Arg Ile Arg Lys Gln Ala Asn Ala His 
1               5                   10                  15      


Ser Lys 
        


<210>  21
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Ser Arg Arg His His Cys Arg Ser Lys Ala Lys Arg Ser Arg His His 
1               5                   10                  15      


<210>  22
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  22

Asn Arg Ala Arg Arg Asn Arg Arg Arg Val Arg 
1               5                   10      


<210>  23
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Arg Gln Leu Arg Ile Ala Gly Arg Arg Leu Arg Gly Arg Ser Arg 
1               5                   10                  15  


<210>  24
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Lys Leu Ile Lys Gly Arg Thr Pro Ile Lys Phe Gly Lys 
1               5                   10              


<210>  25
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Arg Arg Ile Pro Asn Arg Arg Pro Arg Arg 
1               5                   10  


<210>  26
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  27
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  27

Lys Leu Ala Lys Leu Ala Lys Lys Leu Ala Lys Leu Ala Lys 
1               5                   10                  


<210>  28
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  28

Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Asn Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  29
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  30
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  30

Leu Lys Lys Leu Leu Lys Lys Leu Leu Lys Lys Leu Leu Lys Lys Leu 
1               5                   10                  15      


Leu Lys Lys Leu 
            20  


<210>  31
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Gln Ala Ala Thr Ala Thr Arg Gly Arg Ser Ala Ala Ser Arg Pro Thr 
1               5                   10                  15      


Glu Arg Pro Arg Ala Pro Ala Arg Ser Ala Ser Arg Pro Arg Arg Pro 
            20                  25                  30          


Val Glu 
        


<210>  32
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  32

Met Gly Leu Gly Leu His Leu Leu Val Leu Ala Ala Ala Leu Gln Gly 
1               5                   10                  15      


Ala Lys Ser Lys Arg Lys Val 
            20              


<210>  33
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


Ala Ala Ala Asn Tyr Lys Lys Pro Lys Leu 
            20                  25      


<210>  34
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  34

Met Ala Asn Leu Gly Tyr Trp Leu Leu Ala Leu Phe Val Thr Met Trp 
1               5                   10                  15      


Thr Asp Val Gly Leu Cys Lys Lys Arg Pro Lys Pro 
            20                  25              


<210>  35
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  35

Leu Gly Thr Tyr Thr Gln Asp Phe Asn Lys Phe His Thr Phe Pro Gln 
1               5                   10                  15      


Thr Ala Ile Gly Val Gly Ala Pro 
            20                  


<210>  36
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<400>  36

Asp Pro Lys Gly Asp Pro Lys Gly Val Thr Val Thr Val Thr Val Thr 
1               5                   10                  15      


Val Thr Gly Lys Gly Asp Pro Xaa Pro Asp 
            20                  25      


<210>  37
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
1               5                   10                  


<210>  38
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  38

Val Arg Leu Pro Pro Pro Val Arg Leu Pro Pro Pro Val Arg Leu Pro 
1               5                   10                  15      


Pro Pro 
        


<210>  39
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  39

Pro Arg Pro Leu Pro Pro Pro Arg Pro Gly 
1               5                   10  


<210>  40
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  40

Ser Val Arg Arg Arg Pro Arg Pro Pro Tyr Leu Pro Arg Pro Arg Pro 
1               5                   10                  15      


Pro Pro Phe Phe Pro Pro Arg Leu Pro Pro Arg Ile Pro Pro 
            20                  25                  30  


<210>  41
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  41

Thr Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val His 
1               5                   10                  15      


Arg Leu Leu Arg Lys 
            20      


<210>  42
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  42

Gly Ile Gly Lys Phe Leu His Ser Ala Lys Lys Phe Gly Lys Ala Phe 
1               5                   10                  15      


Val Gly Glu Ile Met Asn Ser 
            20              


<210>  43
<211>  37
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  43

Lys Trp Lys Leu Phe Lys Lys Ile Glu Lys Val Gly Gln Asn Ile Arg 
1               5                   10                  15      


Asp Gly Ile Ile Lys Ala Gly Pro Ala Val Ala Val Val Gly Gln Ala 
            20                  25                  30          


Thr Gln Ile Ala Lys 
        35          


<210>  44
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  44

Ala Leu Trp Met Thr Leu Leu Lys Lys Val Leu Lys Ala Ala Ala Lys 
1               5                   10                  15      


Ala Ala Leu Asn Ala Val Leu Val Gly Ala Asn Ala 
            20                  25              


<210>  45
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  45

Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      


Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25      


<210>  46
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  46

Ile Asn Leu Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
1               5                   10                  


<210>  47
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  47

Gly Phe Phe Ala Leu Ile Pro Lys Ile Ile Ser Ser Pro Leu Pro Lys 
1               5                   10                  15      


Thr Leu Leu Ser Ala Val Gly Ser Ala Leu Gly Gly Ser Gly Gly Gln 
            20                  25                  30          


Glu 
    


<210>  48
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  48

Leu Ala Lys Trp Ala Leu Lys Gln Gly Phe Ala Lys Leu Lys Ser 
1               5                   10                  15  


<210>  49
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  49

Ser Met Ala Gln Asp Ile Ile Ser Thr Ile Gly Asp Leu Val Lys Trp 
1               5                   10                  15      


Ile Ile Gln Thr Val Asn Xaa Phe Thr Lys Lys 
            20                  25          


<210>  50
<211>  41
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  50

Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu 
1               5                   10                  15      


Phe Lys Arg Ile Val Gln Arg Ile Lys Gln Arg Ile Lys Asp Phe Leu 
            20                  25                  30          


Ala Asn Leu Val Pro Arg Thr Glu Ser 
        35                  40      


<210>  51
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  51

Pro Ala Trp Arg Lys Ala Phe Arg Trp Ala Trp Arg Met Leu Lys Lys 
1               5                   10                  15      


Ala Ala 
        


<210>  52
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  52

Lys Leu Lys Leu Lys Leu Lys Leu Lys Leu Lys Leu Lys Leu Lys Leu 
1               5                   10                  15      


Lys Leu 
        


<210>  53
<211>  2794
<212>  DNA
<213>  Homo sapiens

<400>  53
cggcaggacc gagcgcggca ggcggctggc ccagcgcagc cagcgcggcc cgaaggacgg       60

gagcaggcgg ccgagcaccg agcgctgggc accgggcacc gagcggcggc ggcacgcgag      120

gcccggcccc gagcagcgcc cccgcccgcc gcggcctcca gcccggcccc gcccagcgcc      180

ggcccgcggg gatgcggagc ggcgggcgcc ggaggccgcg gcccggctag gcccgcgctc      240

gcgcccggac gcggcggccc gaggctgtgg ccaggccagc tgggctcggg gagcgccagc      300

ctgagaggag cgcgtgagcg tcgcgggagc ctcgggcacc atgagcgacg tggctattgt      360

gaaggagggt tggctgcaca aacgagggga gtacatcaag acctggcggc cacgctactt      420

cctcctcaag aatgatggca ccttcattgg ctacaaggag cggccgcagg atgtggacca      480

acgtgaggct cccctcaaca acttctctgt ggcgcagtgc cagctgatga agacggagcg      540

gccccggccc aacaccttca tcatccgctg cctgcagtgg accactgtca tcgaacgcac      600

cttccatgtg gagactcctg aggagcggga ggagtggaca accgccatcc agactgtggc      660

tgacggcctc aagaagcagg aggaggagga gatggacttc cggtcgggct cacccagtga      720

caactcaggg gctgaagaga tggaggtgtc cctggccaag cccaagcacc gcgtgaccat      780

gaacgagttt gagtacctga agctgctggg caagggcact ttcggcaagg tgatcctggt      840

gaaggagaag gccacaggcc gctactacgc catgaagatc ctcaagaagg aagtcatcgt      900

ggccaaggac gaggtggccc acacactcac cgagaaccgc gtcctgcaga actccaggca      960

ccccttcctc acagccctga agtactcttt ccagacccac gaccgcctct gctttgtcat     1020

ggagtacgcc aacgggggcg agctgttctt ccacctgtcc cgggagcgtg tgttctccga     1080

ggaccgggcc cgcttctatg gcgctgagat tgtgtcagcc ctggactacc tgcactcgga     1140

gaagaacgtg gtgtaccggg acctcaagct ggagaacctc atgctggaca aggacgggca     1200

cattaagatc acagacttcg ggctgtgcaa ggaggggatc aaggacggtg ccaccatgaa     1260

gaccttttgc ggcacacctg agtacctggc ccccgaggtg ctggaggaca atgactacgg     1320

ccgtgcagtg gactggtggg ggctgggcgt ggtcatgtac gagatgatgt gcggtcgcct     1380

gcccttctac aaccaggacc atgagaagct ttttgagctc atcctcatgg aggagatccg     1440

cttcccgcgc acgcttggtc ccgaggccaa gtccttgctt tcagggctgc tcaagaagga     1500

ccccaagcag aggcttggcg ggggctccga ggacgccaag gagatcatgc agcatcgctt     1560

ctttgccggt atcgtgtggc agcacgtgta cgagaagaag ctcagcccac ccttcaagcc     1620

ccaggtcacg tcggagactg acaccaggta ttttgatgag gagttcacgg cccagatgat     1680

caccatcaca ccacctgacc aagatgacag catggagtgt gtggacagcg agcgcaggcc     1740

ccacttcccc cagttctcct actcggccag cggcacggcc tgaggcggcg gtggactgcg     1800

ctggacgata gcttggaggg atggagaggc ggcctcgtgc catgatctgt atttaatggt     1860

ttttatttct cgggtgcatt tgagagaagc cacgctgtcc tctcgagccc agatggaaag     1920

acgtttttgt gctgtgggca gcaccctccc ccgcagcggg gtagggaaga aaactatcct     1980

gcgggtttta atttatttca tccagtttgt tctccgggtg tggcctcagc cctcagaaca     2040

atccgattca cgtagggaaa tgttaaggac ttctgcagct atgcgcaatg tggcattggg     2100

gggccgggca ggtcctgccc atgtgtcccc tcactctgtc agccagccgc cctgggctgt     2160

ctgtcaccag ctatctgtca tctctctggg gccctgggcc tcagttcaac ctggtggcac     2220

cagatgcaac ctcactatgg tatgctggcc agcaccctct cctgggggtg gcaggcacac     2280

agcagccccc cagcactaag gccgtgtctc tgaggacgtc atcggaggct gggcccctgg     2340

gatgggacca gggatggggg atgggccagg gtttacccag tgggacagag gagcaaggtt     2400

taaatttgtt attgtgtatt atgttgttca aatgcatttt gggggttttt aatctttgtg     2460

acaggaaagc cctccccctt ccccttctgt gtcacagttc ttggtgactg tcccaccggg     2520

agcctccccc tcagatgatc tctccacggt agcacttgac cttttcgacg cttaaccttt     2580

ccgctgtcgc cccaggccct ccctgactcc ctgtgggggt ggccatccct gggcccctcc     2640

acgcctcctg gccagacgct gccgctgccg ctgcaccacg gcgttttttt acaacattca     2700

actttagtat ttttactatt ataatataat atggaacctt ccctccaaat tcttcaataa     2760

aagttgcttt tcaaaaaaaa aaaaaaaaaa aaaa                                 2794


<210>  54
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 
            20                  25                  30          


Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 
        35                  40                  45              


Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 
    50                  55                  60                  


Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg 
                85                  90                  95      


Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys 
            100                 105                 110         


Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn 
        115                 120                 125             


Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg 
    130                 135                 140                 


Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 
145                 150                 155                 160 


Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr 
                165                 170                 175     


Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 
            180                 185                 190         


Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro 
        195                 200                 205             


Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys 
    210                 215                 220                 


Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser 
225                 230                 235                 240 


Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu 
                245                 250                 255     


Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr 
            260                 265                 270         


Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 
        275                 280                 285             


Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 
    290                 295                 300                 


Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 
305                 310                 315                 320 


Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly 
                325                 330                 335     


Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln 
            340                 345                 350         


Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe 
        355                 360                 365             


Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu 
    370                 375                 380                 


Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys 
385                 390                 395                 400 


Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 
                405                 410                 415     


Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu 
            420                 425                 430         


Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr 
        435                 440                 445             


Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu 
    450                 455                 460                 


Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Thr Ala 
465                 470                 475                 480 


<210>  55
<211>  4904
<212>  DNA
<213>  Homo sapiens

<400>  55
agacactgcg ccgcggctgc gcagtacacg ggaggctttt aattccattg tggagaggac       60

ggcgttattt ttattaactg gaggcgacgg cggctgcggc ggcggcggga cccgcctcct      120

ccggggtatg aaaatcggca gtgggttcct gagtggcggc ggaggtaccg gcagtagcgg      180

tggtagcggc tccggcggcg gtggtagtgg cggcggcggc ggcggcggca gcagcggcag      240

gagggcagag atggaaccca cctttcccca gggtatggtt atgttcaacc accgtcttcc      300

cccggtcacc agcttcaccc ggccggcggg gtcggccgcc cctcccccgc aatgcgtgtt      360

atcctcctct acctccgcag ccccggccgc tgagcccccc cctccgccag ccccggacat      420

gactttcaag aaggagccgg cggcgtcagc cgcggccttc ccctcgcaga ggacctcctg      480

ggggttcttg cagtctttgg ttagcatcaa acaggagaaa cccgcggatc ctgaggagca      540

gcagtcccac caccaccatc accaccacca ctatgggggg ctgttcgctg gagctgaaga      600

gaggtctcca ggcctaggag gcggtgaagg ggggagtcac ggcgtcatcc aggacctcag      660

tattctccac cagcatgtcc agcagcaacc agcccagcac caccgtgacg tattactcag      720

cagcagtagc aggactgatg accaccatgg cactgaggag ccaaagcagg acactaatgt      780

caaaaaggca aaaaggccaa agccagaatc tcagggaatc aaagccaaga ggaagccaag      840

tgcatcttcc aaaccttctt tggttggaga tggagaaggt gccatcctct ccccaagtca      900

gaaacctcat atctgtgatc actgtagtgc tgctttccga agctcctatc acctgcggag      960

acatgtcctc attcatacag gagaaagacc tttccagtgc agccagtgta gtatgggttt     1020

cattcagaaa tacctactac agagacatga gaaaattcat agtagagaga agccatttgg     1080

atgtgatcag tgcagcatga agtttattca gaagtaccat atggagagac acaagaggac     1140

acatagtgga gaaaagccat ataagtgtga cacttgccaa cagtattttt caaggactga     1200

tagattgttg aagcacaggc gcacatgtgg tgaagtcata gttaaaggag ccactagtgc     1260

agaacctggg tcatcaaacc ataccaatat gggtaatctg gctgtgttgt ctcagggaaa     1320

tacaagttct tcaaggagaa aaacaaagtc aaaaagcata gctattgaaa ataaggaaca     1380

gaagaccggt aaaacaaatg aatcgcaaat ttcaaataat ataaacatgc agagttactc     1440

agtagaaatg cctaccgtgt cttccagtgg aggcataatt ggcactggaa tagatgaact     1500

gcagaagagg gtgccaaaat tgatctttaa gaaaggaagc agaaagaata cagataaaaa     1560

ctaccttaac tttgtgtcac cattaccaga catagtagga cagaaatcct tgtctggaaa     1620

accaagtggc tcacttggca tagtatcaaa taatagtgtg gagaccattg gtcttctcca     1680

aagtacaagt ggcaaacaag gtcagataag tagtaattat gatgatgcca tgcagttttc     1740

aaagaaaaga agatatttac caactgccag cagcaacagt gccttttcta taaacgtagg     1800

acacatggtc tcccaacagt ctgtcattca gtctgcaggt gtcagtgttt tggacaatga     1860

ggcaccattg tcacttattg actcctcagc tctaaatgct gaaattaaat cttgtcatga     1920

caagtctgga attcctgatg aggttttaca aagtattttg gatcaatact ccaacaaatc     1980

agaaagccag aaagaggatc ctttcaatat tgcagaacca cgagtggatt tacacacctc     2040

aggagaacac tcagaattgg ttcaagaaga aaatttgagc ccaggcaccc aaacaccttc     2100

aaatgataaa gcaagtatgt tgcaagaata ctccaaatac ctccaacagg cttttgaaaa     2160

atccactaat gcaagtttta ctcttggaca cggtttccaa tttgtcagtt tgtcttcacc     2220

tctccacaac cacactttgt ttccagaaaa acaaatatac actacgtctc ctttggagtg     2280

tggtttcggc caatctgtta cctcagtgtt gccatcttca ttgccaaagc ctccttttgg     2340

gatgttgttt ggatctcagc caggtcttta tttgtctgct ttggatgcta cacatcagca     2400

gttgacacct tcccaggagc tggatgatct gatagattct cagaagaact tagagacttc     2460

atcagccttc cagtcctcat ctcagaaatt gactagccag aaggaacaga aaaacttaga     2520

gtcttcaaca ggctttcaga ttccatctca ggagttagct agccagatag atcctcagaa     2580

agacatagag cctagaacaa cgtatcagat tgagaacttt gcacaagcgt ttggttctca     2640

gtttaagtcg ggcagcaggg tgccaatgac ctttatcact aactctaatg gagaagtgga     2700

ccatagagta aggacttcag tgtcagattt ctcagggtat acaaatatga tgtctgatgt     2760

aagtgagcca tgtagtacaa gagtaaagac acccaccagc cagagttaca ggtaaggtcc     2820

caaaagtggc caggctggag gtcttctaat gtaattttgt tttattttga gaacactgcc     2880

attggaatgt ttctacacga tcctattaag aataatgtga tgccctttca atgcaacttt     2940

tcatatttag tttattttgt tagcgtgatt ttagctctgt ttgtattatg atttttaatc     3000

aaaatcaata gattaaaaat agtttgacat tcaaagtgac aatgtttagc aatcaaattt     3060

acatgtatag atcgtcaggg aatagcccaa atgttttaaa cgcaaaaaaa aagacaaaaa     3120

aaaaccaaaa aaaaaaaacc tacaaaaaaa actttgttgc taggattaag gttattctaa     3180

ttgctttact ctcaggaaag tgtaataacg catgggaatt ctgtacgtta tcactgtaat     3240

ggaatatcca atttacagat agtatgatat acatttcatc atttaagtaa gggatcgaaa     3300

acatttcaaa ttgctctatc tgggctgata gacatttcgt catttaagta agggatcgaa     3360

gacatttcaa attgctatct ccatctgggc tgatccaaaa ttctgagatt gttggctacc     3420

tatattttgt tgcagctttt aaatgtactc tgaacttcca aaccacattc attccagcct     3480

ggtagaacaa atattcttgg atctttgatc aaagcctgga atgatagctt taataaaaga     3540

aggaaaaaaa aaaagcaccc tctcttgatc tcaactgtaa caaggctgta attccatcaa     3600

gcgattctac tgacatctag tacagtgttg aagcccaagt ggttggctgg ttccagtatt     3660

agaactcaag ttgaaattat atgattaact gaaatttggg gcatgcatta tttattatac     3720

atggcctaca acggttctgt ctgcgctgtt acgtattacc tacacttctg ggtttttttg     3780

ttcttgttct cagcctctct ttaagagttc ttgggccttc cttttccctc tttctatttt     3840

aacagtttta attttagaac catttacatt ccagtaggta attcactatg cgctttatat     3900

gccttagggc atccaaataa aaaacaatag ggtaaacatc cccaaaaccc acctttaaaa     3960

aaaaaaaaac ccatacagat ttccatatgt aataaaaccc cgtgttcttg gatagatatt     4020

aataaggttg taattccaac tggtgacata actcctgtga gggataagaa tgtgtctgct     4080

tatagtaata acatcagaac ctctttgtga aattgcggcc tttaatgtac attttaatga     4140

aagggtgcat tagtattgta caggggtctt gtaaagtcat caaaacttgc tatgaactct     4200

aattgccatt tgaagctact gattggcagt ggctctactc taaaactgct ttttagcaat     4260

tgtatttttt tcctgattat attttttaat gtactttgat gtttatgctg atgagttttt     4320

tatgtacttt tggtgatgtt tcagtcttat gtactcttct gacgtcagaa aagtaccact     4380

ggttgtttgc agtcttattg tgtaatcagc ctaccgcagg cttccatgta taataaagta     4440

attaatattg tgcaagtgta aaacacttct gttataaaag cagtgtttgg aaaataagaa     4500

atattaaaaa tggttacaaa gtattagtta atttcctttt cccactttcc tccctttagc     4560

tttagcagct aaagggtcac caacttgtca ttgcaagatt cttagaaaat gtacttaatc     4620

ttaaatacgc tgagtactaa aaagtgttta tttcttattt cagtaagtgc ggtaagttct     4680

attgagtaca gagtacaagc tgtaatcaaa ggatggagag gacctttacc actgtatctc     4740

ttaagctgta tgatttttct ccagtttgtt ttatacaggt tttgaatttc tttaactttt     4800

attgtgtgta ctgaatactg catatgtatt attctgattg tttgctctag tttactacca     4860

ataaaagtcc tgttaatcac aagattaaaa aaaaaaaaaa aaaa                      4904


<210>  56
<211>  895
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Lys Ile Gly Ser Gly Phe Leu Ser Gly Gly Gly Gly Thr Gly Ser 
1               5                   10                  15      


Ser Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Ser Ser Gly Arg Arg Ala Glu Met Glu Pro Thr Phe Pro Gln 
        35                  40                  45              


Gly Met Val Met Phe Asn His Arg Leu Pro Pro Val Thr Ser Phe Thr 
    50                  55                  60                  


Arg Pro Ala Gly Ser Ala Ala Pro Pro Pro Gln Cys Val Leu Ser Ser 
65                  70                  75                  80  


Ser Thr Ser Ala Ala Pro Ala Ala Glu Pro Pro Pro Pro Pro Ala Pro 
                85                  90                  95      


Asp Met Thr Phe Lys Lys Glu Pro Ala Ala Ser Ala Ala Ala Phe Pro 
            100                 105                 110         


Ser Gln Arg Thr Ser Trp Gly Phe Leu Gln Ser Leu Val Ser Ile Lys 
        115                 120                 125             


Gln Glu Lys Pro Ala Asp Pro Glu Glu Gln Gln Ser His His His His 
    130                 135                 140                 


His His His His Tyr Gly Gly Leu Phe Ala Gly Ala Glu Glu Arg Ser 
145                 150                 155                 160 


Pro Gly Leu Gly Gly Gly Glu Gly Gly Ser His Gly Val Ile Gln Asp 
                165                 170                 175     


Leu Ser Ile Leu His Gln His Val Gln Gln Gln Pro Ala Gln His His 
            180                 185                 190         


Arg Asp Val Leu Leu Ser Ser Ser Ser Arg Thr Asp Asp His His Gly 
        195                 200                 205             


Thr Glu Glu Pro Lys Gln Asp Thr Asn Val Lys Lys Ala Lys Arg Pro 
    210                 215                 220                 


Lys Pro Glu Ser Gln Gly Ile Lys Ala Lys Arg Lys Pro Ser Ala Ser 
225                 230                 235                 240 


Ser Lys Pro Ser Leu Val Gly Asp Gly Glu Gly Ala Ile Leu Ser Pro 
                245                 250                 255     


Ser Gln Lys Pro His Ile Cys Asp His Cys Ser Ala Ala Phe Arg Ser 
            260                 265                 270         


Ser Tyr His Leu Arg Arg His Val Leu Ile His Thr Gly Glu Arg Pro 
        275                 280                 285             


Phe Gln Cys Ser Gln Cys Ser Met Gly Phe Ile Gln Lys Tyr Leu Leu 
    290                 295                 300                 


Gln Arg His Glu Lys Ile His Ser Arg Glu Lys Pro Phe Gly Cys Asp 
305                 310                 315                 320 


Gln Cys Ser Met Lys Phe Ile Gln Lys Tyr His Met Glu Arg His Lys 
                325                 330                 335     


Arg Thr His Ser Gly Glu Lys Pro Tyr Lys Cys Asp Thr Cys Gln Gln 
            340                 345                 350         


Tyr Phe Ser Arg Thr Asp Arg Leu Leu Lys His Arg Arg Thr Cys Gly 
        355                 360                 365             


Glu Val Ile Val Lys Gly Ala Thr Ser Ala Glu Pro Gly Ser Ser Asn 
    370                 375                 380                 


His Thr Asn Met Gly Asn Leu Ala Val Leu Ser Gln Gly Asn Thr Ser 
385                 390                 395                 400 


Ser Ser Arg Arg Lys Thr Lys Ser Lys Ser Ile Ala Ile Glu Asn Lys 
                405                 410                 415     


Glu Gln Lys Thr Gly Lys Thr Asn Glu Ser Gln Ile Ser Asn Asn Ile 
            420                 425                 430         


Asn Met Gln Ser Tyr Ser Val Glu Met Pro Thr Val Ser Ser Ser Gly 
        435                 440                 445             


Gly Ile Ile Gly Thr Gly Ile Asp Glu Leu Gln Lys Arg Val Pro Lys 
    450                 455                 460                 


Leu Ile Phe Lys Lys Gly Ser Arg Lys Asn Thr Asp Lys Asn Tyr Leu 
465                 470                 475                 480 


Asn Phe Val Ser Pro Leu Pro Asp Ile Val Gly Gln Lys Ser Leu Ser 
                485                 490                 495     


Gly Lys Pro Ser Gly Ser Leu Gly Ile Val Ser Asn Asn Ser Val Glu 
            500                 505                 510         


Thr Ile Gly Leu Leu Gln Ser Thr Ser Gly Lys Gln Gly Gln Ile Ser 
        515                 520                 525             


Ser Asn Tyr Asp Asp Ala Met Gln Phe Ser Lys Lys Arg Arg Tyr Leu 
    530                 535                 540                 


Pro Thr Ala Ser Ser Asn Ser Ala Phe Ser Ile Asn Val Gly His Met 
545                 550                 555                 560 


Val Ser Gln Gln Ser Val Ile Gln Ser Ala Gly Val Ser Val Leu Asp 
                565                 570                 575     


Asn Glu Ala Pro Leu Ser Leu Ile Asp Ser Ser Ala Leu Asn Ala Glu 
            580                 585                 590         


Ile Lys Ser Cys His Asp Lys Ser Gly Ile Pro Asp Glu Val Leu Gln 
        595                 600                 605             


Ser Ile Leu Asp Gln Tyr Ser Asn Lys Ser Glu Ser Gln Lys Glu Asp 
    610                 615                 620                 


Pro Phe Asn Ile Ala Glu Pro Arg Val Asp Leu His Thr Ser Gly Glu 
625                 630                 635                 640 


His Ser Glu Leu Val Gln Glu Glu Asn Leu Ser Pro Gly Thr Gln Thr 
                645                 650                 655     


Pro Ser Asn Asp Lys Ala Ser Met Leu Gln Glu Tyr Ser Lys Tyr Leu 
            660                 665                 670         


Gln Gln Ala Phe Glu Lys Ser Thr Asn Ala Ser Phe Thr Leu Gly His 
        675                 680                 685             


Gly Phe Gln Phe Val Ser Leu Ser Ser Pro Leu His Asn His Thr Leu 
    690                 695                 700                 


Phe Pro Glu Lys Gln Ile Tyr Thr Thr Ser Pro Leu Glu Cys Gly Phe 
705                 710                 715                 720 


Gly Gln Ser Val Thr Ser Val Leu Pro Ser Ser Leu Pro Lys Pro Pro 
                725                 730                 735     


Phe Gly Met Leu Phe Gly Ser Gln Pro Gly Leu Tyr Leu Ser Ala Leu 
            740                 745                 750         


Asp Ala Thr His Gln Gln Leu Thr Pro Ser Gln Glu Leu Asp Asp Leu 
        755                 760                 765             


Ile Asp Ser Gln Lys Asn Leu Glu Thr Ser Ser Ala Phe Gln Ser Ser 
    770                 775                 780                 


Ser Gln Lys Leu Thr Ser Gln Lys Glu Gln Lys Asn Leu Glu Ser Ser 
785                 790                 795                 800 


Thr Gly Phe Gln Ile Pro Ser Gln Glu Leu Ala Ser Gln Ile Asp Pro 
                805                 810                 815     


Gln Lys Asp Ile Glu Pro Arg Thr Thr Tyr Gln Ile Glu Asn Phe Ala 
            820                 825                 830         


Gln Ala Phe Gly Ser Gln Phe Lys Ser Gly Ser Arg Val Pro Met Thr 
        835                 840                 845             


Phe Ile Thr Asn Ser Asn Gly Glu Val Asp His Arg Val Arg Thr Ser 
    850                 855                 860                 


Val Ser Asp Phe Ser Gly Tyr Thr Asn Met Met Ser Asp Val Ser Glu 
865                 870                 875                 880 


Pro Cys Ser Thr Arg Val Lys Thr Pro Thr Ser Gln Ser Tyr Arg 
                885                 890                 895 


<210>  57
<211>  6950
<212>  DNA
<213>  Homo sapiens

<400>  57
aatcgccggc agcctatgac atcagacagg aacgcctggg atgccgcgct gctcctggcc       60

aacctccgag gaggaggagg gtcccgccgg ctaagagtta attagccccg cacggcgagg      120

ggggaggcgc cagttttctg gggacactgg ctgccactgt actcctaccc aggggagctc      180

acggagagtt ggatgaattc tgggttgtta gctgcggtca gctgggctcc cgggagcctg      240

ttgctggtgg agaacagggg gcgcctggcc aagggaccag cggcttgctg agactcaaca      300

tgacactcct ggggtctgag cattccttgc tgattaggag caagttcaga tcagttttac      360

agttaagact tcaacaaaga aggacccagg aacaactggc taaccaaggc ataataccac      420

cactgaaacg tccagctgaa ttccatgagc aaagaaaaca tttggatagt gacaaggcta      480

aaaattccct gaagcgcaaa gccagaaaca ggtgcaacag tgccgacttg gttaatatgc      540

acatactcca agcttccact gcagagaggt ccattccaac tgctcagatg aagctgaaaa      600

gagcccgact cgccgatgat ctcaatgaaa aaattgctct acgaccaggg ccactggagc      660

tggtggaaaa aaacattctt cctgtggatt ctgctgtgaa agaggccata aaaggtaacc      720

aggtgagttt ctccaaatcc acggatgctt ttgcctttga agaggacagc agcagcgatg      780

ggctttctcc ggatcagact cgaagtgaag acccccaaaa ctcagcggga tccccgccag      840

acgctaaagc ctcagatacc ccttcgacag gttctctggg gacaaaccag gatcttgctt      900

ctggctcaga aaatgacaga aatgactcag cctcacagcc cagccaccag tcagatgcgg      960

ggaagcaggg gcttggcccc cccagcaccc ccatagccgt gcatgctgct gtaaagtcca     1020

aatccttggg tgacagtaag aaccgccaca aaaagcccaa ggaccccaag ccaaaggtga     1080

agaagcttaa atatcaccag tacattcccc cagaccagaa ggcagagaag tcccctccac     1140

ctatggactc agcctacgct cggctgctcc agcaacagca gctgttcctg cagctccaaa     1200

tcctcagcca gcagcagcag cagcagcaac accgattcag ctacctaggg atgcaccaag     1260

ctcagcttaa ggaaccaaat gaacagatgg tcagaaatcc aaactcttct tcaacgccac     1320

tgagcaatac ccccttgtct cctgtcaaaa acagtttttc tggacaaact ggtgtctctt     1380

ctttcaaacc aggcccactc ccacctaacc tggatgatct gaaggtctct gaattaagac     1440

aacagcttcg aattcggggc ttgcctgtgt caggcaccaa aacggctctc atggaccggc     1500

ttcgaccctt ccaggactgc tctggcaacc cagtgccgaa ctttggggat ataacgactg     1560

tcacttttcc tgtcacaccc aacacgctgc ccaattacca gtcttcctct tctaccagtg     1620

ccctgtccaa cggcttctac cactttggca gcaccagctc cagccccccg atctccccag     1680

cctcctctga cctgtcagtc gctgggtccc tgccggacac cttcaatgat gcctccccct     1740

ccttcggcct gcacccgtcc ccagtccacg tgtgcacgga ggaaagtctc atgagcagcc     1800

tgaatggggg ctctgttcct tctgagctgg atgggctgga ctccgagaag gacaagatgc     1860

tggtggagaa gcagaaggtg atcaatgaac tcacctggaa actccagcaa gagcagaggc     1920

aggtggagga gctgaggatg cagcttcaga agcagaaaag gaataactgt tcagagaaga     1980

agccgctgcc tttcctggct gcctccatca agcaggaaga ggctgtctcc agctgtcctt     2040

ttgcatccca agtacctgtg aaaagacaaa gcagcagctc agagtgtcac ccaccggctt     2100

gtgaagctgc tcaactccag cctcttggaa atgctcattg tgtggagtcc tcagatcaaa     2160

ccaatgtact ttcttccaca tttctcagcc cccagtgttc ccctcagcat tcaccgctgg     2220

gggctgtgaa aagcccacag cacatcagtt tgcccccatc acccaacaac cctcactttc     2280

tgccctcatc ctccggggcc cagggagaag ggcacagggt ctcctcgccc atcagcagcc     2340

aggtgtgcac tgcacagaac tcaggagcac acgatggcca tcctccaagc ttctctcccc     2400

attcttccag cctccacccg cccttctctg gagcccaagc agacagcagt catggtgccg     2460

ggggaaaccc ttgtcccaaa agcccatgtg tacagcaaaa gatggctggt ttacactctt     2520

ctgataaggt ggggccaaag ttttcaattc catccccaac tttttctaag tcaagttcag     2580

caatttcaga ggtaacacag cctccatcct atgaagatgc cgtaaagcag caaatgaccc     2640

ggagtcagca gatggatgaa ctcctggacg tgcttattga aagcggagaa atgccagcag     2700

acgctagaga ggatcactca tgtcttcaaa aagtcccaaa gatacccaga tcttcccgaa     2760

gtccaactgc tgtcctcacc aagccctcgg cttcctttga acaagcctct tcaggcagcc     2820

agatcccctt tgatccctat gccaccgaca gtgatgagca tcttgaagtc ttattaaatt     2880

cccagagccc cctaggaaag atgagtgatg tcacccttct aaaaattggg agcgaagagc     2940

ctcactttga tgggataatg gatggattct ctgggaaggc tgcagaagac ctcttcaatg     3000

cacatgagat cttgccaggc cccctctctc caatgcagac acagttttca ccctcttctg     3060

tggacagcaa tgggctgcag ttaagcttca ctgaatctcc ctgggaaacc atggagtggc     3120

tggacctcac tccgccaaat tccacaccag gctttagcgc cctcaccacc agcagcccca     3180

gcatcttcaa catcgatttc ctggatgtca ctgatctcaa tttgaattct tccatggacc     3240

ttcacttgca gcagtggtag aatgcccaat gcaccagtgc tatggaagac caatggagtt     3300

ccatggggga aagcacacag ccatacatac tttactgtcc aaaaacagaa gaagaagaag     3360

agaattaaaa agaagcaatg atttctgtgc caatgaacaa gaacaaaagt catttttaga     3420

aatacatata ctgtaatatt taccaacagt cagtaactgt taatgatttc aacaatgcat     3480

taaaagaatg tgctttctca gattaaggat gccaaaaaag atatttcact gccttttcaa     3540

agaccagtat attttctagc ccataatttt tctcaggcat tgttggggca taagctcaca     3600

ctgtaagctt ttctcatgaa ttcactagac ataacgtgga aggaaaacgt agtcttttgg     3660

gagtacaggg aagccagccc ctcaaagctt atggaagaca tacctgcaat ggaagctgtt     3720

gcccaatgtc tccattacta tctttcaaaa gagaagccag acccagcttc agatcaaaag     3780

ttcttgagac agaggaacaa aaccaatcga tttccaggga agctaatcaa ctctcttttc     3840

cctctaccac aaaactgccc tgctggagtg gttctgaacc tgtacccagg actcgatgtg     3900

gtcactaata acaattaacc tgaactgagt ccacagaact ccactcggaa ctttcttctt     3960

ttttaactag tggcccaatc attcccacca tctctgtgct gataagtacg tgtcctagat     4020

gagaaccctg aagaatgcag accttcttcc cccgaaggag atgccacaag ctctccaaca     4080

cagccccctt tagttccaaa gactagagat gaccacattg gtagaagtat atctcgaggc     4140

acaggaaggg agccccacca gggataattc agacaggact agagaataac atcatttcac     4200

ataccctggg ataaacaccc tgggttccta tagaaggact attacttatg ggagtccaac     4260

ttctcctttt gttttgttat tatcagttta tctttctccc actccacttt tccttcaagg     4320

taccaatcct ttcctgttcc tcgtttggcc atctttcttt ttctgcctcc acattgggag     4380

gggaggactt ctcagttcta acaagctgcc atactcctaa gaaagccatt tttgaaaaat     4440

ttaacaatcc aggttcttct ggagaactca ttctccacac gcacagtttg ctgcaaaagg     4500

aagttgcaag aatttcttga ggaagaaact ggtgacttgg tccatcagtc acgaagttct     4560

ttctattctc gtttagtttt caagaaatta ttggtttgtg ttgctctggg gaaattggaa     4620

atcattacat tgtaaagaca aatatggatg atatttacaa gagagaattt cagatctggg     4680

tttttgaaag aaaacagaat tgcgcattga aaacgatgga aggaaaaaga caatggtcta     4740

atgtgcattc ctcattacct ctcgtggctt tggctgggag ttggaaaaag ctaaaatttc     4800

agaacagtct ctgtaaggct ctctgtggct ccagttcacc attttatatt gttgcatgct     4860

gtagaaagga gctattgctg ttgttttgtt tttttattta aatcactaag gcactgtttt     4920

tatcttttgt aaaaaaaaaa aaaaagttgt tcactgtgca cttatagaaa aaataatcaa     4980

aaatgttggg attttagaag ctctcttttt gataaaccaa agatttagaa gtcattccat     5040

tgttaacttg taaaaatgtg tgaacacaga gagtttttgg tgattgctac tctgaaagct     5100

gccagatctt attctggggg tgggatgtgg aggaatacac atacacacac aaacatacat     5160

gtatgtataa tagatatata catatgtgta tattatatct gtgtgtgcat gtatctccaa     5220

aagcggcgtt acagagttct acaccaaaag cctttaaccc ttaatctgct gtgaatgata     5280

cctggccttt ctcactatga atttctgatt aaccaaccag actacacgtt gcctctctgt     5340

gtatgactaa cggctccaac ccgatgactc acagctactt gcttatcgtg aacaagctca     5400

tcttggcaat gaatatggat gtgaaaagac agaacagctt caccattagt agctggaaat     5460

ggtatcacag tctcttatag aggaatatga aaggaacaag aaaatcattt tacattcctt     5520

ttatctgtat tgtgctttaa aagatccaca tggtaaattt tttattttgc ttttatgtca     5580

gtcatcagaa ccaaaaaaat ccagaagaaa aaattgccag tgtttccttt gaagatgaag     5640

ctactgggga agaaaacctt attaatacac tccacacatt tgttcattcc tcagctgttg     5700

gtgttttctt ggggtcttga caaagcttgc tggtcagtgc acttttcagg tgtcacgttt     5760

tgctgtttgt atgttttttc ttccccttac ttcctttgga aaacaaactc acacagtgcc     5820

cctactctga gacctgggac tgagtgttaa ttattttttc cttgggtatt tctatctgag     5880

agactagacc tagttaggag gcctctgtac ttctccagat tgtacctttt tatggggatc     5940

tttgaggcta tgacccagga ctgatagata tgccttacgg aagacaaaag ataaaatggt     6000

tcctatatcc taatgcaaac caacacagtt aaaagagcag atctctggat aactgctctc     6060

aacctgcttc tacagtctcc acaaaccgca ttcaccctct ctcttcatag ctcagacatg     6120

aaatttgagg gagaaaactg gagataattg ggagaaaatt gatgaagttg gctgcttcca     6180

gtagatcaga taatccatga atttgtctcc cattgagaat tttattttaa attcttttaa     6240

actcttcgtt gtgtcttttg tgatgacaaa tcaggcatga ctaaaagatg tacagagact     6300

tacgaagatg gtcacattca agttccctaa tgctcttaga acctgaagat gaccatgtgt     6360

agttttctta agacctctga acccccatgg tgatgaagac ttgaagacat ttgcagctat     6420

ctgctgcagt ctggtagatt catacttatc taaagaagtc aaaaaattta ttcgtgcaag     6480

tgcttgcagg aagccagtgc ttattagtag tgaccctgct tctatcaacg ttattgagac     6540

aacacatatt ctattctaag ggagaaagag ggaggaagag agggagggag ggaggaagaa     6600

gagggaggga gcgaggaagg aagataggag atgggtaggg gggtaaagag aaaaggaggg     6660

agaagggaag gaaggaaaga agagaggaaa gaaaggaggg aaggaaaaaa gggccaaact     6720

ttctgatcta tgaacttctc agttcagctg tcacattatg agaagtaaat cagaattttt     6780

ttaaggagaa gtcattctta gcactacaat aattgtacca gtaattgagg aaaccaagac     6840

aatcttcacc tgaataatag agggtctgag aactgtcagc cttttgccat tcaaaaacat     6900

ttatgtccaa cctgaaaaaa aagcatcaat aaaacctatc ccaagcattc                6950


<210>  58
<211>  986
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Thr Leu Leu Gly Ser Glu His Ser Leu Leu Ile Arg Ser Lys Phe 
1               5                   10                  15      


Arg Ser Val Leu Gln Leu Arg Leu Gln Gln Arg Arg Thr Gln Glu Gln 
            20                  25                  30          


Leu Ala Asn Gln Gly Ile Ile Pro Pro Leu Lys Arg Pro Ala Glu Phe 
        35                  40                  45              


His Glu Gln Arg Lys His Leu Asp Ser Asp Lys Ala Lys Asn Ser Leu 
    50                  55                  60                  


Lys Arg Lys Ala Arg Asn Arg Cys Asn Ser Ala Asp Leu Val Asn Met 
65                  70                  75                  80  


His Ile Leu Gln Ala Ser Thr Ala Glu Arg Ser Ile Pro Thr Ala Gln 
                85                  90                  95      


Met Lys Leu Lys Arg Ala Arg Leu Ala Asp Asp Leu Asn Glu Lys Ile 
            100                 105                 110         


Ala Leu Arg Pro Gly Pro Leu Glu Leu Val Glu Lys Asn Ile Leu Pro 
        115                 120                 125             


Val Asp Ser Ala Val Lys Glu Ala Ile Lys Gly Asn Gln Val Ser Phe 
    130                 135                 140                 


Ser Lys Ser Thr Asp Ala Phe Ala Phe Glu Glu Asp Ser Ser Ser Asp 
145                 150                 155                 160 


Gly Leu Ser Pro Asp Gln Thr Arg Ser Glu Asp Pro Gln Asn Ser Ala 
                165                 170                 175     


Gly Ser Pro Pro Asp Ala Lys Ala Ser Asp Thr Pro Ser Thr Gly Ser 
            180                 185                 190         


Leu Gly Thr Asn Gln Asp Leu Ala Ser Gly Ser Glu Asn Asp Arg Asn 
        195                 200                 205             


Asp Ser Ala Ser Gln Pro Ser His Gln Ser Asp Ala Gly Lys Gln Gly 
    210                 215                 220                 


Leu Gly Pro Pro Ser Thr Pro Ile Ala Val His Ala Ala Val Lys Ser 
225                 230                 235                 240 


Lys Ser Leu Gly Asp Ser Lys Asn Arg His Lys Lys Pro Lys Asp Pro 
                245                 250                 255     


Lys Pro Lys Val Lys Lys Leu Lys Tyr His Gln Tyr Ile Pro Pro Asp 
            260                 265                 270         


Gln Lys Ala Glu Lys Ser Pro Pro Pro Met Asp Ser Ala Tyr Ala Arg 
        275                 280                 285             


Leu Leu Gln Gln Gln Gln Leu Phe Leu Gln Leu Gln Ile Leu Ser Gln 
    290                 295                 300                 


Gln Gln Gln Gln Gln Gln His Arg Phe Ser Tyr Leu Gly Met His Gln 
305                 310                 315                 320 


Ala Gln Leu Lys Glu Pro Asn Glu Gln Met Val Arg Asn Pro Asn Ser 
                325                 330                 335     


Ser Ser Thr Pro Leu Ser Asn Thr Pro Leu Ser Pro Val Lys Asn Ser 
            340                 345                 350         


Phe Ser Gly Gln Thr Gly Val Ser Ser Phe Lys Pro Gly Pro Leu Pro 
        355                 360                 365             


Pro Asn Leu Asp Asp Leu Lys Val Ser Glu Leu Arg Gln Gln Leu Arg 
    370                 375                 380                 


Ile Arg Gly Leu Pro Val Ser Gly Thr Lys Thr Ala Leu Met Asp Arg 
385                 390                 395                 400 


Leu Arg Pro Phe Gln Asp Cys Ser Gly Asn Pro Val Pro Asn Phe Gly 
                405                 410                 415     


Asp Ile Thr Thr Val Thr Phe Pro Val Thr Pro Asn Thr Leu Pro Asn 
            420                 425                 430         


Tyr Gln Ser Ser Ser Ser Thr Ser Ala Leu Ser Asn Gly Phe Tyr His 
        435                 440                 445             


Phe Gly Ser Thr Ser Ser Ser Pro Pro Ile Ser Pro Ala Ser Ser Asp 
    450                 455                 460                 


Leu Ser Val Ala Gly Ser Leu Pro Asp Thr Phe Asn Asp Ala Ser Pro 
465                 470                 475                 480 


Ser Phe Gly Leu His Pro Ser Pro Val His Val Cys Thr Glu Glu Ser 
                485                 490                 495     


Leu Met Ser Ser Leu Asn Gly Gly Ser Val Pro Ser Glu Leu Asp Gly 
            500                 505                 510         


Leu Asp Ser Glu Lys Asp Lys Met Leu Val Glu Lys Gln Lys Val Ile 
        515                 520                 525             


Asn Glu Leu Thr Trp Lys Leu Gln Gln Glu Gln Arg Gln Val Glu Glu 
    530                 535                 540                 


Leu Arg Met Gln Leu Gln Lys Gln Lys Arg Asn Asn Cys Ser Glu Lys 
545                 550                 555                 560 


Lys Pro Leu Pro Phe Leu Ala Ala Ser Ile Lys Gln Glu Glu Ala Val 
                565                 570                 575     


Ser Ser Cys Pro Phe Ala Ser Gln Val Pro Val Lys Arg Gln Ser Ser 
            580                 585                 590         


Ser Ser Glu Cys His Pro Pro Ala Cys Glu Ala Ala Gln Leu Gln Pro 
        595                 600                 605             


Leu Gly Asn Ala His Cys Val Glu Ser Ser Asp Gln Thr Asn Val Leu 
    610                 615                 620                 


Ser Ser Thr Phe Leu Ser Pro Gln Cys Ser Pro Gln His Ser Pro Leu 
625                 630                 635                 640 


Gly Ala Val Lys Ser Pro Gln His Ile Ser Leu Pro Pro Ser Pro Asn 
                645                 650                 655     


Asn Pro His Phe Leu Pro Ser Ser Ser Gly Ala Gln Gly Glu Gly His 
            660                 665                 670         


Arg Val Ser Ser Pro Ile Ser Ser Gln Val Cys Thr Ala Gln Asn Ser 
        675                 680                 685             


Gly Ala His Asp Gly His Pro Pro Ser Phe Ser Pro His Ser Ser Ser 
    690                 695                 700                 


Leu His Pro Pro Phe Ser Gly Ala Gln Ala Asp Ser Ser His Gly Ala 
705                 710                 715                 720 


Gly Gly Asn Pro Cys Pro Lys Ser Pro Cys Val Gln Gln Lys Met Ala 
                725                 730                 735     


Gly Leu His Ser Ser Asp Lys Val Gly Pro Lys Phe Ser Ile Pro Ser 
            740                 745                 750         


Pro Thr Phe Ser Lys Ser Ser Ser Ala Ile Ser Glu Val Thr Gln Pro 
        755                 760                 765             


Pro Ser Tyr Glu Asp Ala Val Lys Gln Gln Met Thr Arg Ser Gln Gln 
    770                 775                 780                 


Met Asp Glu Leu Leu Asp Val Leu Ile Glu Ser Gly Glu Met Pro Ala 
785                 790                 795                 800 


Asp Ala Arg Glu Asp His Ser Cys Leu Gln Lys Val Pro Lys Ile Pro 
                805                 810                 815     


Arg Ser Ser Arg Ser Pro Thr Ala Val Leu Thr Lys Pro Ser Ala Ser 
            820                 825                 830         


Phe Glu Gln Ala Ser Ser Gly Ser Gln Ile Pro Phe Asp Pro Tyr Ala 
        835                 840                 845             


Thr Asp Ser Asp Glu His Leu Glu Val Leu Leu Asn Ser Gln Ser Pro 
    850                 855                 860                 


Leu Gly Lys Met Ser Asp Val Thr Leu Leu Lys Ile Gly Ser Glu Glu 
865                 870                 875                 880 


Pro His Phe Asp Gly Ile Met Asp Gly Phe Ser Gly Lys Ala Ala Glu 
                885                 890                 895     


Asp Leu Phe Asn Ala His Glu Ile Leu Pro Gly Pro Leu Ser Pro Met 
            900                 905                 910         


Gln Thr Gln Phe Ser Pro Ser Ser Val Asp Ser Asn Gly Leu Gln Leu 
        915                 920                 925             


Ser Phe Thr Glu Ser Pro Trp Glu Thr Met Glu Trp Leu Asp Leu Thr 
    930                 935                 940                 


Pro Pro Asn Ser Thr Pro Gly Phe Ser Ala Leu Thr Thr Ser Ser Pro 
945                 950                 955                 960 


Ser Ile Phe Asn Ile Asp Phe Leu Asp Val Thr Asp Leu Asn Leu Asn 
                965                 970                 975     


Ser Ser Met Asp Leu His Leu Gln Gln Trp 
            980                 985     


<210>  59
<211>  2490
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  59
agcactctct cacttctggc cagggaacgt ggaaggcgca ccgacaggga tccggccagg       60

gagggcgagt gaaagaagga aatcagaaag gaagggagtt aacaaaataa taaaaacagc      120

ctgagccacg gctggagaga ccgagacccg gcgcaagaga gcgcagcctt agtaggagag      180

gaacgcgaga cgcggcagag cgcgttcagc actgactttt gctgctgctt ctgctttttt      240

ttttcttaga aacaagaagg cgccagcggc agcctcacac gcgagcgcca cgcgaggctc      300

ccgaagccaa cccgcgaagg gaggagggga gggaggagga ggcggcgtgc agggaggaga      360

aaaagcattt tcactttttt tgctcccact ctaagaagtc tcccggggat tttgtatata      420

ttttttaact tccgtcaggg ctcccgcttc atatttcctt ttctttccct ctctgttcct      480

gcacccaagt tctctctgtg tccccctcgc gggccccgca cctcgcgtcc cggatcgctc      540

tgattccgcg actccttggc cgccgctgcg catggaaagc tctgccaaga tggagagcgg      600

cggcgccggc cagcagcccc agccgcagcc ccagcagccc ttcctgccgc ccgcagcctg      660

tttctttgcc acggccgcag ccgcggcggc cgcagccgcc gcagcggcag cgcagagcgc      720

gcagcagcag cagcagcagc agcagcagca gcagcaggcg ccgcagctga gaccggcggc      780

cgacggccag ccctcagggg gcggtcacaa gtcagcgccc aagcaagtca agcgacagcg      840

ctcgtcttcg cccgaactga tgcgctgcaa acgccggctc aacttcagcg gctttggcta      900

cagcctgccg cagcagcagc cggccgccgt ggcgcgccgc aacgagcgcg agcgcaaccg      960

cgtcaagttg gtcaacctgg gctttgccac ccttcgggag cacgtcccca acggcgcggc     1020

caacaagaag atgagtaagg tggagacact gcgctcggcg gtcgagtaca tccgcgcgct     1080

gcagcagctg ctggacgagc atgacgcggt gagcgccgcc ttccaggcag gcgtcctgtc     1140

gcccaccatc tcccccaact actccaacga cttgaactcc atggccggct cgccggtctc     1200

atcctactcg tcggacgagg gctcttacga cccgctcagc cccgaggagc aggagcttct     1260

cgacttcacc aactggttct gaggggctcg gcctggtcag gccctggtgc gaatggactt     1320

tggaagcagg gtgatcgcac aacctgcatc tttagtgctt tcttgtcagt ggcgttggga     1380

gggggagaaa aggaaaagaa aaaaaaaaga agaagaagaa gaaaagagaa gaagaaaaaa     1440

acgaaaacag tcaaccaacc ccatcgccaa ctaagcgagg catgcctgag agacatggct     1500

ttcagaaaac gggaagcgct cagaacagta tctttgcact ccaatcattc acggagatat     1560

gaagagcaac tgggacctga gtcaatgcgc aaaatgcagc ttgtgtgcaa aagcagtggg     1620

ctcctggcag aagggagcag cacacgcgtt atagtaactc ccatcacctc taacacgcac     1680

agctgaaagt tcttgctcgg gtcccttcac ctcctcgccc tttcttaaag tgcagttctt     1740

agccctctag aaacgagttg gtgtctttcg tctcagtagc ccccacccca ataagctgta     1800

gacattggtt tacagtgaaa ctatgctatt ctcagccctt tgaaactctg cttctcctcc     1860

agggcccgat tcccaaaccc catggcttcc ctcacactgt cttttctacc attttcatta     1920

tagaatgctt ccaatctttt gtgaattttt tattataaaa aatctatttg tatctatcct     1980

aaccagttcg gggatatatt aagatatttt tgtacataag agagaaagag agagaaaaat     2040

ttatagaagt tttgtacaaa tggtttaaaa tgtgtatatc ttgatacttt aacatgtaat     2100

gctattacct ctgcatattt tagatgtgta gttcacctta caactgcaat tttccctatg     2160

tggttttgta aagaactctc ctcataggtg agatcaagag gccaccagtt gtacttcagc     2220

accaatgtgt cttactttat agaaatgttg ttaatgtatt aatgatgtta ttaaatactg     2280

ttcaagaaga acaaagttta tgcagctact gtccaaactc aaagtggcag ccagttggtt     2340

ttgataggtt gccttttgga gatttctatt actgcctttt tttttcttac tgttttatta     2400

caaacttaca aaaatatgta taaccctgtt ttatacaaac tagtttcgta ataaaacttt     2460

ttcctttttt taaaatgaaa ataaaaaaaa                                      2490


<210>  60
<211>  236
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  60

Met Glu Ser Ser Ala Lys Met Glu Ser Gly Gly Ala Gly Gln Gln Pro 
1               5                   10                  15      


Gln Pro Gln Pro Gln Gln Pro Phe Leu Pro Pro Ala Ala Cys Phe Phe 
            20                  25                  30          


Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln 
        35                  40                  45              


Ser Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Pro 
    50                  55                  60                  


Gln Leu Arg Pro Ala Ala Asp Gly Gln Pro Ser Gly Gly Gly His Lys 
65                  70                  75                  80  


Ser Ala Pro Lys Gln Val Lys Arg Gln Arg Ser Ser Ser Pro Glu Leu 
                85                  90                  95      


Met Arg Cys Lys Arg Arg Leu Asn Phe Ser Gly Phe Gly Tyr Ser Leu 
            100                 105                 110         


Pro Gln Gln Gln Pro Ala Ala Val Ala Arg Arg Asn Glu Arg Glu Arg 
        115                 120                 125             


Asn Arg Val Lys Leu Val Asn Leu Gly Phe Ala Thr Leu Arg Glu His 
    130                 135                 140                 


Val Pro Asn Gly Ala Ala Asn Lys Lys Met Ser Lys Val Glu Thr Leu 
145                 150                 155                 160 


Arg Ser Ala Val Glu Tyr Ile Arg Ala Leu Gln Gln Leu Leu Asp Glu 
                165                 170                 175     


His Asp Ala Val Ser Ala Ala Phe Gln Ala Gly Val Leu Ser Pro Thr 
            180                 185                 190         


Ile Ser Pro Asn Tyr Ser Asn Asp Leu Asn Ser Met Ala Gly Ser Pro 
        195                 200                 205             


Val Ser Ser Tyr Ser Ser Asp Glu Gly Ser Tyr Asp Pro Leu Ser Pro 
    210                 215                 220                 


Glu Glu Gln Glu Leu Leu Asp Phe Thr Asn Trp Phe 
225                 230                 235     


