                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
       DISKIN, Ron
       COHEN-DVASHI, Hadas
 
<120>  IMMUNOTHERAPY AGAINST TRANSFERRIN RECEPTOR 1 (TFR1)-TROPIC 
       ARENAVIRUSES

<130>  74272

<150>  IL 253984
<151>  2017-08-14

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  2629
<212>  DNA
<213>  homo sapiens

<400>  1
ctcgggacgg aggacgcgct agtgttcttc tgtgtggcag ttcagaatga tggatcaagc       60

tagatcagca ttctctaact tgtttggtgg agaaccattg tcatataccc ggttcagcct      120

ggctcggcaa gtagatggcg ataacagtca tgtggagatg aaacttgctg tagatgaaga      180

agaaaatgct gacaataaca caaaggccaa tgtcacaaaa ccaaaaaggt gtagtggaag      240

tatctgctat gggactattg ctgtgatcgt ctttttcttg attggattta tgattggcta      300

cttgggctat tgtaaagggg tagaaccaaa aactgagtgt gagagactgg caggaaccga      360

gtctccagtg agggaggagc caggagagga cttccctgca gcacgtcgct tatattggga      420

tgacctgaag agaaagttgt cggagaaact ggacagcaca gacttcaccg gcaccatcaa      480

gctgctgaat gaaaattcat atgtccctcg tgaggctgga tctcaaaaag atgaaaatct      540

tgcgttgtat gttgaaaatc aatttcgtga atttaaactc agcaaagtct ggcgtgatca      600

acattttgtt aagattcagg tcaaagacag cgctcaaaac tcggtgatca tagttgataa      660

gaacggtaga cttgtttacc tggtggagaa tcctgggggt tatgtggcgt atagtaaggc      720

tgcaacagtt actggtaaac tggtccatgc taattttggt actaaaaaag attttgagga      780

tttatacact cctgtgaatg gatctatagt gattgtcaga gcagggaaaa tcacctttgc      840

agaaaaggtt gcaaatgctg aaagcttaaa tgcaattggt gtgttgatat acatggacca      900

gactaaattt cccattgtta acgcagaact ttcattcttt ggacatgctc atctggggac      960

aggtgaccct tacacacctg gattcccttc cttcaatcac actcagtttc caccatctcg     1020

gtcatcagga ttgcctaata tacctgtcca gacaatctcc agagctgctg cagaaaagct     1080

gtttgggaat atggaaggag actgtccctc tgactggaaa acagactcta catgtaggat     1140

ggtaacctca gaaagcaaga atgtgaagct cactgtgagc aatgtgctga aagagataaa     1200

aattcttaac atctttggag ttattaaagg ctttgtagaa ccagatcact atgttgtagt     1260

tggggcccag agagatgcat ggggccctgg agctgcaaaa tccggtgtag gcacagctct     1320

cctattgaaa cttgcccaga tgttctcaga tatggtctta aaagatgggt ttcagcccag     1380

cagaagcatt atctttgcca gttggagtgc tggagacttt ggatcggttg gtgccactga     1440

atggctagag ggataccttt cgtccctgca tttaaaggct ttcacttata ttaatctgga     1500

taaagcggtt cttggtacca gcaacttcaa ggtttctgcc agcccactgt tgtatacgct     1560

tattgagaaa acaatgcaaa atgtgaagca tccggttact gggcaatttc tatatcagga     1620

cagcaactgg gccagcaaag ttgagaaact cactttagac aatgctgctt tccctttcct     1680

tgcatattct ggaatcccag cagtttcttt ctgtttttgc gaggacacag attatcctta     1740

tttgggtacc accatggaca cctataagga actgattgag aggattcctg agttgaacaa     1800

agtggcacga gcagctgcag aggtcgctgg tcagttcgtg attaaactaa cccatgatgt     1860

tgaattgaac ctggactatg agaggtacaa cagccaactg ctttcatttg tgagggatct     1920

gaaccaatac agagcagaca taaaggaaat gggcctgagt ttacagtggc tgtattctgc     1980

tcgtggagac ttcttccgtg ctacttccag actaacaaca gatttcggga atgctgagaa     2040

aacagacaga tttgtcatga agaaactcaa tgatcgtgtc atgagagtgg agtatcactt     2100

cctctctccc tacgtatctc caaaagagtc tcctttccga catgtcttct ggggctccgg     2160

ctctcacacg ctgccagctt tactggagaa cttgaaactg cgtaaacaaa ataacggtgc     2220

ttttaatgaa acgctgttca gaaaccagtt ggctctagct acttggacta ttcagggagc     2280

tgcaaatgcc ctctctggtg acgtttggga cattgacaat gagttttaaa tgtgataccc     2340

atagcttcca tgagaacagc agggtagtct ggtttctaga cttgtgctga tcgtgctaaa     2400

ttttcagtag ggctacaaaa cctgatgtta aaattccatc ccatcatctt ggtactacta     2460

gatgtcttta ggcagcagct tttaatacag ggtagataac ctgtacttca agttaaagtg     2520

aataaccact taaaaaatgt ccatgatgga atattcccct atctctagaa ttttaagtgc     2580

tttgtaatgg gaactgcctc tttcctgttg ttgttaatga aaatgtcag                 2629


<210>  2
<211>  760
<212>  PRT
<213>  homo sapiens

<400>  2

Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala 
        35                  40                  45              


Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly 
    50                  55                  60                  


Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly 
65                  70                  75                  80  


Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr 
                85                  90                  95      


Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro 
            100                 105                 110         


Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys 
        115                 120                 125             


Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Gly Thr Ile 
    130                 135                 140                 


Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln 
145                 150                 155                 160 


Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe 
                165                 170                 175     


Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val 
            180                 185                 190         


Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg 
        195                 200                 205             


Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys 
    210                 215                 220                 


Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys 
225                 230                 235                 240 


Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile 
                245                 250                 255     


Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu 
            260                 265                 270         


Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe 
        275                 280                 285             


Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly 
    290                 295                 300                 


Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln 
305                 310                 315                 320 


Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr 
                325                 330                 335     


Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp 
            340                 345                 350         


Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser 
        355                 360                 365             


Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile 
    370                 375                 380                 


Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp 
385                 390                 395                 400 


His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala 
                405                 410                 415     


Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met 
            420                 425                 430         


Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile 
        435                 440                 445             


Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr 
    450                 455                 460                 


Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr 
465                 470                 475                 480 


Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val 
                485                 490                 495     


Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn 
            500                 505                 510         


Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp 
        515                 520                 525             


Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe 
    530                 535                 540                 


Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp 
545                 550                 555                 560 


Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu 
                565                 570                 575     


Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu 
            580                 585                 590         


Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn 
        595                 600                 605             


Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp 
    610                 615                 620                 


Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln 
625                 630                 635                 640 


Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu 
                645                 650                 655     


Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys 
            660                 665                 670         


Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro 
        675                 680                 685             


Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser 
    690                 695                 700                 


Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys 
705                 710                 715                 720 


Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala 
                725                 730                 735     


Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp 
            740                 745                 750         


Val Trp Asp Ile Asp Asn Glu Phe 
        755                 760 


<210>  3
<211>  2286
<212>  DNA
<213>  neotoma albigula

<400>  3
atgatggatc aagccagatc agcaatctct aacttgtttg gtggagaacc attgtcgtac       60

acccggttta gcctggctcg gcaagtagat ggagataaca gtcatgtgga gatgaaattg      120

gctgtagatg aagaagaaac tactgacaat aacatgaagg ccagtgtcag aaaacccaga      180

agggttaatg ggagactctg ctatgggaca attgcagtag tcatcttttt cttgattgga      240

tttatggtcg gctacctggg ctattgtaaa cgcggagaac agaaagactg cgtgagactg      300

gcagacgcgg agacagacac ctcacaaagc ttccaaatag aagaagacgt tcctaaacct      360

tctcgcttat tttggtcaga cctcaaaaat ctattgtcag agaaactgga tgctatagag      420

ttcactgaca ccatcaagca gctgagccag aatacaaata cccctcggga ggctggatct      480

caaaaagatg aaaatcttgc ctatgatatt gaaaatcagt tccatgactt taaactcagc      540

aaagtctggc gagatgaaca ctatgtgaag atccaggtga aaggcagcgt tgctccaaac      600

tcggtgacca taacaaatgc aagtggtggc ttgtacctag tggagtatcc tgagggttat      660

gtggcgtata gtaaagctac agaagttact ggtaaactgg tccatgctaa ttttggcact      720

aaaaaggact ttgaagattt agattatgct gtgaatggat ctatagtgat tgttagagca      780

gggaaaatca ctattgcaga aaaggttgca aatgcccaaa gctttaatgc aattggtgtc      840

ctgatataca tggacaggac taagttcccc attgttaggg cagacattcc actctttgga      900

catgctcatc taggaaccgg tgacccatac acacctggct ttccatcttt caaccatact      960

cagtttccgc catcccaatc atcaggattg cctagtatac ctgttcaaac aatctcaaga     1020

gaggctgcag aaaagctatt tcagaacatg gaaagagact gtcctcgtag ttggaacaca     1080

gattcttcct gtaagctgga attgttacag aacagaaatg tgaagctcac tgtgaacaat     1140

gcactgaaag aaacgagaat acttaacatc tttggcctta ttaaaggttt tgaggaacca     1200

gaccgttaca ttgtagtagg agcccagaga gatgcctggg gtcctggtgc tgcaaagtcc     1260

agtgtgggaa caggtcttct gttgaaactt gcccaagtat tctcagatat ggtttcaaga     1320

ggtgggttta aacccagcag aagcattatc tttgccagct ggagtgcagg agacttcgga     1380

gctgttggtg ccactgagtg gctagaggga tacctttcat ctctgcattt aaaagctttc     1440

acttatatta atctggataa agttgtcctt ggtactagca acttcaaagt ttctgccagc     1500

cctctattat atacacttat tgggaagaca atgcaagatg taaagcatcc aattgatggg     1560

aaatctctat atcgagacag caattggatt agcaaagctg agaagctttc ccttgacaat     1620

gctgctttcc cttttcttgc atattctgga atcccagcag tttccttctg tttttgtgag     1680

gatgaggact atccttattt gggcactact ttggatacct atgagagact gattgacaaa     1740

gttcctcagc tgaacaaaat ggttcgtgca gcagcagaag tggctggtca gttcattatt     1800

aaacttaccc atgaaattga actgaacctg gactatgata tgtataacag caaaatactg     1860

gcatttgtga gggatctgaa ccagttcaga gcagatttca gggcgatggg tctgagtcta     1920

cagtggctgt attctgctcg tggagacttc ttccgtgcta catctagact aacgaatgat     1980

ttccataatg ctgagaaaac aaacagattt gtcatgagag aaatcaatga tcggattatg     2040

aaagtggaat atcacttcct gtcaccctac gtatctccaa gagagtttcc tttccgacac     2100

atcttctggg gctctggctc tcacactctt ccagctttag tggagaactt gaaccttcgt     2160

cagagaaata ttactgcttt taatgaaaca ctattcagaa accagttggc cctggctact     2220

tggactattc agggagttgc aaatgctctc tctggtgaca tttggaatat tgacaatgag     2280

ttttaa                                                                2286


<210>  4
<211>  761
<212>  PRT
<213>  neotoma albigula

<400>  4

Met Met Asp Gln Ala Arg Ser Ala Ile Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Thr Thr 
        35                  40                  45              


Asp Asn Asn Met Lys Ala Ser Val Arg Lys Pro Arg Arg Val Asn Gly 
    50                  55                  60                  


Arg Leu Cys Tyr Gly Thr Ile Ala Val Val Ile Phe Phe Leu Ile Gly 
65                  70                  75                  80  


Phe Met Val Gly Tyr Leu Gly Tyr Cys Lys Arg Gly Glu Gln Lys Asp 
                85                  90                  95      


Cys Val Arg Leu Ala Asp Ala Glu Thr Asp Thr Ser Gln Ser Phe Gln 
            100                 105                 110         


Ile Glu Glu Asp Val Pro Lys Pro Ser Arg Leu Phe Trp Ser Asp Leu 
        115                 120                 125             


Lys Asn Leu Leu Ser Glu Lys Leu Asp Ala Ile Glu Phe Thr Asp Thr 
    130                 135                 140                 


Ile Lys Gln Leu Ser Gln Asn Thr Asn Thr Pro Arg Glu Ala Gly Ser 
145                 150                 155                 160 


Gln Lys Asp Glu Asn Leu Ala Tyr Asp Ile Glu Asn Gln Phe His Asp 
                165                 170                 175     


Phe Lys Leu Ser Lys Val Trp Arg Asp Glu His Tyr Val Lys Ile Gln 
            180                 185                 190         


Val Lys Gly Ser Val Ala Pro Asn Ser Val Thr Ile Thr Asn Ala Ser 
        195                 200                 205             


Gly Gly Leu Tyr Leu Val Glu Tyr Pro Glu Gly Tyr Val Ala Tyr Ser 
    210                 215                 220                 


Lys Ala Thr Glu Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr 
225                 230                 235                 240 


Lys Lys Asp Phe Glu Asp Leu Asp Tyr Ala Val Asn Gly Ser Ile Val 
                245                 250                 255     


Ile Val Arg Ala Gly Lys Ile Thr Ile Ala Glu Lys Val Ala Asn Ala 
            260                 265                 270         


Gln Ser Phe Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Arg Thr Lys 
        275                 280                 285             


Phe Pro Ile Val Arg Ala Asp Ile Pro Leu Phe Gly His Ala His Leu 
    290                 295                 300                 


Gly Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr 
305                 310                 315                 320 


Gln Phe Pro Pro Ser Gln Ser Ser Gly Leu Pro Ser Ile Pro Val Gln 
                325                 330                 335     


Thr Ile Ser Arg Glu Ala Ala Glu Lys Leu Phe Gln Asn Met Glu Arg 
            340                 345                 350         


Asp Cys Pro Arg Ser Trp Asn Thr Asp Ser Ser Cys Lys Leu Glu Leu 
        355                 360                 365             


Leu Gln Asn Arg Asn Val Lys Leu Thr Val Asn Asn Ala Leu Lys Glu 
    370                 375                 380                 


Thr Arg Ile Leu Asn Ile Phe Gly Leu Ile Lys Gly Phe Glu Glu Pro 
385                 390                 395                 400 


Asp Arg Tyr Ile Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly 
                405                 410                 415     


Ala Ala Lys Ser Ser Val Gly Thr Gly Leu Leu Leu Lys Leu Ala Gln 
            420                 425                 430         


Val Phe Ser Asp Met Val Ser Arg Gly Gly Phe Lys Pro Ser Arg Ser 
        435                 440                 445             


Ile Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ala Val Gly Ala 
    450                 455                 460                 


Thr Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe 
465                 470                 475                 480 


Thr Tyr Ile Asn Leu Asp Lys Val Val Leu Gly Thr Ser Asn Phe Lys 
                485                 490                 495     


Val Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Gly Lys Thr Met Gln 
            500                 505                 510         


Asp Val Lys His Pro Ile Asp Gly Lys Ser Leu Tyr Arg Asp Ser Asn 
        515                 520                 525             


Trp Ile Ser Lys Ala Glu Lys Leu Ser Leu Asp Asn Ala Ala Phe Pro 
    530                 535                 540                 


Phe Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu 
545                 550                 555                 560 


Asp Glu Asp Tyr Pro Tyr Leu Gly Thr Thr Leu Asp Thr Tyr Glu Arg 
                565                 570                 575     


Leu Ile Asp Lys Val Pro Gln Leu Asn Lys Met Val Arg Ala Ala Ala 
            580                 585                 590         


Glu Val Ala Gly Gln Phe Ile Ile Lys Leu Thr His Glu Ile Glu Leu 
        595                 600                 605             


Asn Leu Asp Tyr Asp Met Tyr Asn Ser Lys Ile Leu Ala Phe Val Arg 
    610                 615                 620                 


Asp Leu Asn Gln Phe Arg Ala Asp Phe Arg Ala Met Gly Leu Ser Leu 
625                 630                 635                 640 


Gln Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg 
                645                 650                 655     


Leu Thr Asn Asp Phe His Asn Ala Glu Lys Thr Asn Arg Phe Val Met 
            660                 665                 670         


Arg Glu Ile Asn Asp Arg Ile Met Lys Val Glu Tyr His Phe Leu Ser 
        675                 680                 685             


Pro Tyr Val Ser Pro Arg Glu Phe Pro Phe Arg His Ile Phe Trp Gly 
    690                 695                 700                 


Ser Gly Ser His Thr Leu Pro Ala Leu Val Glu Asn Leu Asn Leu Arg 
705                 710                 715                 720 


Gln Arg Asn Ile Thr Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu 
                725                 730                 735     


Ala Leu Ala Thr Trp Thr Ile Gln Gly Val Ala Asn Ala Leu Ser Gly 
            740                 745                 750         


Asp Ile Trp Asn Ile Asp Asn Glu Phe 
        755                 760     


<210>  5
<211>  516
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic acid sequence of Tfr1 soluble apical domain

<400>  5
ggatccaaga ttcaggtcaa atgttcagct cctaactctg tcacaattac taacgcatca       60

ggcggactgt atctggtgga ataccccgag ggctacgtgg cctattctaa ggccaccgag      120

gtgacaggca agctggtgca cgccaacttc ggcaccaaga aggactttga ggacctggat      180

tacgccgtga atggctccat cgtgatcgtg cgggccggca agatcaccat cgccgagaag      240

gtggccaacg cccagtcctt caatgccatc ggcgtgctga tctacaagga caggacaaag      300

tatccaatct ctagggcaga tgagccactg cagggacact ctggcctgcc aagcatccct      360

gtgcagacca tcagcaggga ggcagcagag aagctgtttc agaacatgga gcgggactgc      420

cccagatcct ggaatacaga tagctcctgt aagctggagc tgctgcagaa caggaatgtg      480

aagctgaccg tgaataactg cctgaaggag ggtacc                                516


<210>  6
<211>  170
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of Tfr1 soluble apical domain

<400>  6

Gly Ser Lys Ile Gln Val Lys Cys Ser Ala Pro Asn Ser Val Thr Ile 
1               5                   10                  15      


Thr Asn Ala Ser Gly Gly Leu Tyr Leu Val Glu Tyr Pro Glu Gly Tyr 
            20                  25                  30          


Val Ala Tyr Ser Lys Ala Thr Glu Val Thr Gly Lys Leu Val His Ala 
        35                  40                  45              


Asn Phe Gly Thr Lys Lys Asp Phe Glu Asp Leu Asp Tyr Ala Val Asn 
    50                  55                  60                  


Gly Ser Ile Val Ile Val Arg Ala Gly Lys Ile Thr Ile Ala Glu Lys 
65                  70                  75                  80  


Val Ala Asn Ala Gln Ser Phe Asn Ala Ile Gly Val Leu Ile Tyr Lys 
                85                  90                  95      


Asp Arg Thr Lys Tyr Pro Ile Ser Arg Ala Asp Glu Pro Leu Gln Gly 
            100                 105                 110         


His Ser Gly Leu Pro Ser Ile Pro Val Gln Thr Ile Ser Arg Glu Ala 
        115                 120                 125             


Ala Glu Lys Leu Phe Gln Asn Met Glu Arg Asp Cys Pro Arg Ser Trp 
    130                 135                 140                 


Asn Thr Asp Ser Ser Cys Lys Leu Glu Leu Leu Gln Asn Arg Asn Val 
145                 150                 155                 160 


Lys Leu Thr Val Asn Asn Cys Leu Lys Glu 
                165                 170 


<210>  7
<211>  1230
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic acid sequence of ARENACEPT

<400>  7
ggatccaaga ttcaggtcaa atgttcagct cctaactctg tcacaattac taacgcatca       60

ggcggactgt atctggtgga ataccccgag ggctacgtgg cctattctaa ggccaccgag      120

gtgacaggca agctggtgca cgccaacttc ggcaccaaga aggactttga ggacctggat      180

tacgccgtga atggctccat cgtgatcgtg cgggccggca agatcaccat cgccgagaag      240

gtggccaacg cccagtcctt caatgccatc ggcgtgctga tctacaagga caggacaaag      300

tatccaatct ctagggcaga tgagccactg cagggacact ctggcctgcc aagcatccct      360

gtgcagacca tcagcaggga ggcagcagag aagctgtttc agaacatgga gcgggactgc      420

cccagatcct ggaatacaga tagctcctgt aagctggagc tgctgcagaa caggaatgtg      480

aagctgaccg tgaataactg cctgaaggag ggtaccgaga acttgtactt ccagggtagt      540

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      600

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      660

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      720

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      780

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      840

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      900

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag      960

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1020

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1080

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     1140

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1200

ctctccctgt ccccgggtaa atagcggccg                                      1230


<210>  8
<211>  407
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of ARENACEPT

<400>  8

Gly Ser Lys Ile Gln Val Lys Cys Ser Ala Pro Asn Ser Val Thr Ile 
1               5                   10                  15      


Thr Asn Ala Ser Gly Gly Leu Tyr Leu Val Glu Tyr Pro Glu Gly Tyr 
            20                  25                  30          


Val Ala Tyr Ser Lys Ala Thr Glu Val Thr Gly Lys Leu Val His Ala 
        35                  40                  45              


Asn Phe Gly Thr Lys Lys Asp Phe Glu Asp Leu Asp Tyr Ala Val Asn 
    50                  55                  60                  


Gly Ser Ile Val Ile Val Arg Ala Gly Lys Ile Thr Ile Ala Glu Lys 
65                  70                  75                  80  


Val Ala Asn Ala Gln Ser Phe Asn Ala Ile Gly Val Leu Ile Tyr Lys 
                85                  90                  95      


Asp Arg Thr Lys Tyr Pro Ile Ser Arg Ala Asp Glu Pro Leu Gln Gly 
            100                 105                 110         


His Ser Gly Leu Pro Ser Ile Pro Val Gln Thr Ile Ser Arg Glu Ala 
        115                 120                 125             


Ala Glu Lys Leu Phe Gln Asn Met Glu Arg Asp Cys Pro Arg Ser Trp 
    130                 135                 140                 


Asn Thr Asp Ser Ser Cys Lys Leu Glu Leu Leu Gln Asn Arg Asn Val 
145                 150                 155                 160 


Lys Leu Thr Val Asn Asn Cys Leu Lys Glu Gly Thr Glu Asn Leu Tyr 
                165                 170                 175     


Phe Gln Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            180                 185                 190         


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        195                 200                 205             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    210                 215                 220                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
225                 230                 235                 240 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                245                 250                 255     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            260                 265                 270         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        275                 280                 285             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    290                 295                 300                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
305                 310                 315                 320 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                325                 330                 335     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            340                 345                 350         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        355                 360                 365             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    370                 375                 380                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
385                 390                 395                 400 


Leu Ser Leu Ser Pro Gly Lys 
                405         


<210>  9
<211>  2237
<212>  DNA
<213>  Neacomys spinosus

<400>  9
aacttgtttg gtggagaacc attatcgtat actcggttta gcctggctca gcaagtagat       60

ggagataaca gccatgtgga gatgaaattg gctgtagatg aagaggagaa tgtggacaac      120

atgaaggcca gcgtcagaaa acccaaaagg tttaatggag gaagactctg ctttgggaca      180

attgcagtag tcatcttttt cttgattgga tttatgattg gctacctggg atattgtaaa      240

cgcatagaac aaaaagaatg tgcgagactg gcagaaacgg agacagtcag ttcacaaaac      300

ctccaaccag aagaagacat tcctaaatct tctcgcttat attgggcaga cctcaaaaaa      360

ctgttgtcag agaaattgga tgccatagac ttcactgacc ctatcaagca gctgagccaa      420

aatacataca cccctcggga ggctggatct caaaaagatg aaaatcttgc ctattatatt      480

gaaaatcaat ttcatgactt taaactcagc aaagtctggc gagatgagca ttatgtgaag      540

cttcaggtga aaggcagcac tgatcaaaac tcagtgacca taataaattc aagtggtggc      600

ttgtaccttc tggagagtcc tgagggttat gtggcatata gcaaagctgc agaagttact      660

ggtaaactgg tccatgctaa ttttggcacc aaaaaagact ttgaaaactt aaattatgct      720

gtgaatggat ccttagtgat tgttagagca ggggaaatca cttttgcaga aaaggttgca      780

aatgcccaaa actttaatgc aattggtgtc ttgatataca tggacaagaa taaattccca      840

gttgttaagg cagaccttcc actctttgga catgctcatc taggaactgg tgacccatac      900

acacctggct ttccatcttt caaccatact caatttccac catctcagtc atcaggattg      960

cctagtatac ctgttcaaac aatctcaaga gagactgcgg acaagctatt tcaaaatatg     1020

gaaggaaact gtcctcctgg ttggaatgta gattcttcgt gtaagctaga attgacttcc     1080

aataaaaatg tgaagctcac tgtgaaaaat gaactgaaag agacaagaat acttaacatc     1140

tttggagtta ttaaaggttt tgaggaacca ggccattaca ttgtagtagg agcccagaga     1200

gattcctggg gtcctggtgc tgcaaagtcc agtgtgggaa cagctcttct gttgaaactt     1260

gcccaaacat tctcagatat ggttttaaga ggtggattta aacccagcag aagcattatc     1320

tttgccagct ggactgcagg agactttgga gctgttggtg ccaccgagtg gctagaggga     1380

tacctttcat ctctgcattt aaaagccttc acttacatta atctggataa agttgtcctt     1440

ggttctagca acttcaaggt ttctgccagc cctctgttat atacacttat tgagaagaca     1500

atgcaggacg taaagcatcc aattgatggg aagtctctat atcgagatag caactggatc     1560

agcaaagtta agaaactttc ccttgacaac gccgctttcc cgtttcttgc atattctgga     1620

atcccagcag tttctttctg tttttgtgag gatgaggact atccttattt ggacactact     1680

ttggatacct atgagttact aattcagaaa gttcctcagt tgggtaaaat ggttcgtgta     1740

gctgcagaag tggctggtca gttcattatt aaacttactc atgaaattga attgaacctg     1800

gactatgaca tgtataacaa caaatactgt aacaacaaaa tactgtcatt tgtgagggat     1860

ctgaaccagt tcagagcgga tatcagggag atgggtctaa gtctacagtg gctgtattct     1920

gctcgcggag actactttcg tgctacatct agactaacat ctgacttcca taatgcagag     1980

aaaacaaaca gatttgtcat gagggaaatc aatgaccgta ttatgaaagt ggaatatcat     2040

ttcctgtcac cctatgtatc tcccagagag tctcctttcc gacacatctt ctggggttat     2100

ggctctcaca ctctcccagc tttaatggag aacttgaagc ttcggcagaa aaatattagt     2160

gcttttaatg aaacactctt cagaaaccag ttggccctag ctacttggac tattcaggga     2220

gttgcaaatg ccctctc                                                    2237


<210>  10
<211>  746
<212>  PRT
<213>  Neacomys spinosus

<400>  10

Asn Leu Phe Gly Gly Glu Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala 
1               5                   10                  15      


Gln Gln Val Asp Gly Asp Asn Ser His Val Glu Met Lys Leu Ala Val 
            20                  25                  30          


Asp Glu Glu Glu Asn Val Asp Asn Met Lys Ala Ser Val Arg Lys Pro 
        35                  40                  45              


Lys Arg Phe Asn Gly Gly Arg Leu Cys Phe Gly Thr Ile Ala Val Val 
    50                  55                  60                  


Ile Phe Phe Leu Ile Gly Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys 
65                  70                  75                  80  


Arg Ile Glu Gln Lys Glu Cys Ala Arg Leu Ala Glu Thr Glu Thr Val 
                85                  90                  95      


Ser Ser Gln Asn Leu Gln Pro Glu Glu Asp Ile Pro Lys Ser Ser Arg 
            100                 105                 110         


Leu Tyr Trp Ala Asp Leu Lys Lys Leu Leu Ser Glu Lys Leu Asp Ala 
        115                 120                 125             


Ile Asp Phe Thr Asp Pro Ile Lys Gln Leu Ser Gln Asn Thr Tyr Thr 
    130                 135                 140                 


Pro Arg Glu Ala Gly Ser Gln Lys Asp Glu Asn Leu Ala Tyr Tyr Ile 
145                 150                 155                 160 


Glu Asn Gln Phe His Asp Phe Lys Leu Ser Lys Val Trp Arg Asp Glu 
                165                 170                 175     


His Tyr Val Lys Leu Gln Val Lys Gly Ser Thr Asp Gln Asn Ser Val 
            180                 185                 190         


Thr Ile Ile Asn Ser Ser Gly Gly Leu Tyr Leu Leu Glu Ser Pro Glu 
        195                 200                 205             


Gly Tyr Val Ala Tyr Ser Lys Ala Ala Glu Val Thr Gly Lys Leu Val 
    210                 215                 220                 


His Ala Asn Phe Gly Thr Lys Lys Asp Phe Glu Asn Leu Asn Tyr Ala 
225                 230                 235                 240 


Val Asn Gly Ser Leu Val Ile Val Arg Ala Gly Glu Ile Thr Phe Ala 
                245                 250                 255     


Glu Lys Val Ala Asn Ala Gln Asn Phe Asn Ala Ile Gly Val Leu Ile 
            260                 265                 270         


Tyr Met Asp Lys Asn Lys Phe Pro Val Val Lys Ala Asp Leu Pro Leu 
        275                 280                 285             


Phe Gly His Ala His Leu Gly Thr Gly Asp Pro Tyr Thr Pro Gly Phe 
    290                 295                 300                 


Pro Ser Phe Asn His Thr Gln Phe Pro Pro Ser Gln Ser Ser Gly Leu 
305                 310                 315                 320 


Pro Ser Ile Pro Val Gln Thr Ile Ser Arg Glu Thr Ala Asp Lys Leu 
                325                 330                 335     


Phe Gln Asn Met Glu Gly Asn Cys Pro Pro Gly Trp Asn Val Asp Ser 
            340                 345                 350         


Ser Cys Lys Leu Glu Leu Thr Ser Asn Lys Asn Val Lys Leu Thr Val 
        355                 360                 365             


Lys Asn Glu Leu Lys Glu Thr Arg Ile Leu Asn Ile Phe Gly Val Ile 
    370                 375                 380                 


Lys Gly Phe Glu Glu Pro Gly His Tyr Ile Val Val Gly Ala Gln Arg 
385                 390                 395                 400 


Asp Ser Trp Gly Pro Gly Ala Ala Lys Ser Ser Val Gly Thr Ala Leu 
                405                 410                 415     


Leu Leu Lys Leu Ala Gln Thr Phe Ser Asp Met Val Leu Arg Gly Gly 
            420                 425                 430         


Phe Lys Pro Ser Arg Ser Ile Ile Phe Ala Ser Trp Thr Ala Gly Asp 
        435                 440                 445             


Phe Gly Ala Val Gly Ala Thr Glu Trp Leu Glu Gly Tyr Leu Ser Ser 
    450                 455                 460                 


Leu His Leu Lys Ala Phe Thr Tyr Ile Asn Leu Asp Lys Val Val Leu 
465                 470                 475                 480 


Gly Ser Ser Asn Phe Lys Val Ser Ala Ser Pro Leu Leu Tyr Thr Leu 
                485                 490                 495     


Ile Glu Lys Thr Met Gln Asp Val Lys His Pro Ile Asp Gly Lys Ser 
            500                 505                 510         


Leu Tyr Arg Asp Ser Asn Trp Ile Ser Lys Val Lys Lys Leu Ser Leu 
        515                 520                 525             


Asp Asn Ala Ala Phe Pro Phe Leu Ala Tyr Ser Gly Ile Pro Ala Val 
    530                 535                 540                 


Ser Phe Cys Phe Cys Glu Asp Glu Asp Tyr Pro Tyr Leu Asp Thr Thr 
545                 550                 555                 560 


Leu Asp Thr Tyr Glu Leu Leu Ile Gln Lys Val Pro Gln Leu Gly Lys 
                565                 570                 575     


Met Val Arg Val Ala Ala Glu Val Ala Gly Gln Phe Ile Ile Lys Leu 
            580                 585                 590         


Thr His Glu Ile Glu Leu Asn Leu Asp Tyr Asp Met Tyr Asn Asn Lys 
        595                 600                 605             


Tyr Cys Asn Asn Lys Ile Leu Ser Phe Val Arg Asp Leu Asn Gln Phe 
    610                 615                 620                 


Arg Ala Asp Ile Arg Glu Met Gly Leu Ser Leu Gln Trp Leu Tyr Ser 
625                 630                 635                 640 


Ala Arg Gly Asp Tyr Phe Arg Ala Thr Ser Arg Leu Thr Ser Asp Phe 
                645                 650                 655     


His Asn Ala Glu Lys Thr Asn Arg Phe Val Met Arg Glu Ile Asn Asp 
            660                 665                 670         


Arg Ile Met Lys Val Glu Tyr His Phe Leu Ser Pro Tyr Val Ser Pro 
        675                 680                 685             


Arg Glu Ser Pro Phe Arg His Ile Phe Trp Gly Tyr Gly Ser His Thr 
    690                 695                 700                 


Leu Pro Ala Leu Met Glu Asn Leu Lys Leu Arg Gln Lys Asn Ile Ser 
705                 710                 715                 720 


Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala Leu Ala Thr Trp 
                725                 730                 735     


Thr Ile Gln Gly Val Ala Asn Ala Leu Ser 
            740                 745     


<210>  11
<211>  2282
<212>  DNA
<213>  Artibeus jamaicensis


<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  n is a, c, g, or t

<400>  11
aacttgttta gtggagaacc attgtcatac acccggttta gtctcgcacg gcnagtggat       60

ggcgataaca gtcgtgtgga gatgaaacta gcagcagacg aggaagaaaa tgatgacaat      120

cacatgagga gcaattatgc ccatgttgca aaatcaaaaa agtttaatgg aagtatctgc      180

tacggaacta ttgctataat catctttttc ttcattggat ttatgattgg ctacttgggc      240

tattgtaaac gtgtggaacc aaaagctgaa tgtgaaagaa cagagtctcc gggtacagag      300

gagtctccag tggagacagt agactacctt tccgaaacac ctccccgttt gttttggtca      360

cacctcaaag cagtgttgtc agagaaactg aataacgttg acttcgccaa cacaatcaag      420

cagctaaatg aaaattccta tgtccctcgt gaggctggat ctcaacaaga tgaaagcctt      480

gctttttatc ttgaaggtca atttcgtaaa tttcaactca gcaaagcctg gcacgatgaa      540

cattttgtca aggttcaggt caaaggcagt gctcaaaatg cagtgaccat agtggctgtg      600

agcagtggtg caggatacct ggtggagaac cctgcaggtt acgtggcgta cagcaagacc      660

ggaacagtta ctggtaaact ggtccatgct aattttggca ctaaacaaga ctttgaaagt      720

tcaagcattc ctgtgaatgg atctttagtg attgttagag cagggaaaat cacttttgct      780

gaaaaggttg caaatgctca aagttttaat gcaattggtg ttttgatcta catggactat      840

actaaatttc ccattgttaa tgcacagctt ccactctttg gacatgctca tctgggaaca      900

ggtgaccctt acacacccgg atttccttct ttcaatcaca ctcagtttcc accatcgcag      960

tcatcaggat tgcctaccat acctgtccaa acaatttcca gagccgctgc agagaaactg     1020

tttgaaaata tggagcaact ctgtccttct gcttggagaa cagactcttc atgtaggctg     1080

gtaacaaaaa aggataggaa tgtgaaactc actgtgagca atgtactgaa agagacaaga     1140

attttaaatg tctttggtgt tattaaaggc tttgaagaac ccgatcgcta tgttgtggtg     1200

ggggcccaga gggatgcctg gggccctgga gctgtgaagt ccagtgtggg aacagctctc     1260

ctattggaac ttgcccggat attttctgat atggtcttaa aaggtgggtt taagcccagc     1320

agaagcattg tcttcgccag ctggagcgca ggagactttg gagccgtggg cgctactgaa     1380

tggctggagg gatacctttc ctccttgcat ttaaaggctt tcacttacat taatctggat     1440

aaagctgtcc ttagtgacgg caacttaaag gtttctgcca gcccactgtt gtattcactt     1500

attgagaaaa cgatgcaaga agtgaaacat ccagttactg ggctttcttt atatcgggat     1560

agcaactgga tcaaaaaagt tgagaaactt tctttggata atgctgcttt ccctttcctt     1620

gcgtattctg gaatcccagc agtttctttc tgtttttgtg aggacttgga ttatccttat     1680

ttaggtacta ccctggatac ctatgaggca ctgtatggga gagtccctga gttgaacaga     1740

atggtacgtg gagcagcaga agtggctggc cagctcatga ttagacttac ccatgatgtt     1800

gaattgaacc tgaactatga catgtataat gaggaaatac ttgaatttgt gagggatatg     1860

aaccagttca gaagagacgt aaaggagatg ggtctgatct acagtgctgt atctgctcgc     1920

ggagacttct tcgtgctact tctaactcac agcagatata gatgcgaaag acaacgattg     1980

tcacgtgcta cttctaaact cacagcagat tataagaatg cggagagaac caacagattt     2040

gtcatgaggg aaatcaatga ccgtatcatg agagtggaat accacttcct ctcaccctat     2100

gtatctccaa gagattctcc tttccgacat atcttctggg gctctggctc tcacactctg     2160

tcagctttac tagagcactt aaagctgcgt cgagaaaata acagtgcttt caatgaaaca     2220

ctgttgagaa accagttggc tttagcaact tggacaattc agggagctgc aaatgctctc     2280

tc                                                                    2282


<210>  12
<211>  761
<212>  PRT
<213>  Artibeus jamaicensis


<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Asn Leu Phe Ser Gly Glu Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala 
1               5                   10                  15      


Arg Xaa Val Asp Gly Asp Asn Ser Arg Val Glu Met Lys Leu Ala Ala 
            20                  25                  30          


Asp Glu Glu Glu Asn Asp Asp Asn His Met Arg Ser Asn Tyr Ala His 
        35                  40                  45              


Val Ala Lys Ser Lys Lys Phe Asn Gly Ser Ile Cys Tyr Gly Thr Ile 
    50                  55                  60                  


Ala Ile Ile Ile Phe Phe Phe Ile Gly Phe Met Ile Gly Tyr Leu Gly 
65                  70                  75                  80  


Tyr Cys Lys Arg Val Glu Pro Lys Ala Glu Cys Glu Arg Thr Glu Ser 
                85                  90                  95      


Pro Gly Thr Glu Glu Ser Pro Val Glu Thr Val Asp Tyr Leu Ser Glu 
            100                 105                 110         


Thr Pro Pro Arg Leu Phe Trp Ser His Leu Lys Ala Val Leu Ser Glu 
        115                 120                 125             


Lys Leu Asn Asn Val Asp Phe Ala Asn Thr Ile Lys Gln Leu Asn Glu 
    130                 135                 140                 


Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln Gln Asp Glu Ser Leu 
145                 150                 155                 160 


Ala Phe Tyr Leu Glu Gly Gln Phe Arg Lys Phe Gln Leu Ser Lys Ala 
                165                 170                 175     


Trp His Asp Glu His Phe Val Lys Val Gln Val Lys Gly Ser Ala Gln 
            180                 185                 190         


Asn Ala Val Thr Ile Val Ala Val Ser Ser Gly Ala Gly Tyr Leu Val 
        195                 200                 205             


Glu Asn Pro Ala Gly Tyr Val Ala Tyr Ser Lys Thr Gly Thr Val Thr 
    210                 215                 220                 


Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys Gln Asp Phe Glu Ser 
225                 230                 235                 240 


Ser Ser Ile Pro Val Asn Gly Ser Leu Val Ile Val Arg Ala Gly Lys 
                245                 250                 255     


Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Gln Ser Phe Asn Ala Ile 
            260                 265                 270         


Gly Val Leu Ile Tyr Met Asp Tyr Thr Lys Phe Pro Ile Val Asn Ala 
        275                 280                 285             


Gln Leu Pro Leu Phe Gly His Ala His Leu Gly Thr Gly Asp Pro Tyr 
    290                 295                 300                 


Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln Phe Pro Pro Ser Gln 
305                 310                 315                 320 


Ser Ser Gly Leu Pro Thr Ile Pro Val Gln Thr Ile Ser Arg Ala Ala 
                325                 330                 335     


Ala Glu Lys Leu Phe Glu Asn Met Glu Gln Leu Cys Pro Ser Ala Trp 
            340                 345                 350         


Arg Thr Asp Ser Ser Cys Arg Leu Val Thr Lys Lys Asp Arg Asn Val 
        355                 360                 365             


Lys Leu Thr Val Ser Asn Val Leu Lys Glu Thr Arg Ile Leu Asn Val 
    370                 375                 380                 


Phe Gly Val Ile Lys Gly Phe Glu Glu Pro Asp Arg Tyr Val Val Val 
385                 390                 395                 400 


Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala Val Lys Ser Ser Val 
                405                 410                 415     


Gly Thr Ala Leu Leu Leu Glu Leu Ala Arg Ile Phe Ser Asp Met Val 
            420                 425                 430         


Leu Lys Gly Gly Phe Lys Pro Ser Arg Ser Ile Val Phe Ala Ser Trp 
        435                 440                 445             


Ser Ala Gly Asp Phe Gly Ala Val Gly Ala Thr Glu Trp Leu Glu Gly 
    450                 455                 460                 


Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr Tyr Ile Asn Leu Asp 
465                 470                 475                 480 


Lys Ala Val Leu Ser Asp Gly Asn Leu Lys Val Ser Ala Ser Pro Leu 
                485                 490                 495     


Leu Tyr Ser Leu Ile Glu Lys Thr Met Gln Glu Val Lys His Pro Val 
            500                 505                 510         


Thr Gly Leu Ser Leu Tyr Arg Asp Ser Asn Trp Ile Lys Lys Val Glu 
        515                 520                 525             


Lys Leu Ser Leu Asp Asn Ala Ala Phe Pro Phe Leu Ala Tyr Ser Gly 
    530                 535                 540                 


Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp Leu Asp Tyr Pro Tyr 
545                 550                 555                 560 


Leu Gly Thr Thr Leu Asp Thr Tyr Glu Ala Leu Tyr Gly Arg Val Pro 
                565                 570                 575     


Glu Leu Asn Arg Met Val Arg Gly Ala Ala Glu Val Ala Gly Gln Leu 
            580                 585                 590         


Met Ile Arg Leu Thr His Asp Val Glu Leu Asn Leu Asn Tyr Asp Met 
        595                 600                 605             


Tyr Asn Glu Glu Ile Leu Glu Phe Val Arg Asp Met Asn Gln Phe Arg 
    610                 615                 620                 


Arg Asp Val Lys Glu Met Gly Leu Ile Tyr Ser Ala Val Ser Ala Arg 
625                 630                 635                 640 


Gly Asp Phe Phe Val Leu Leu Leu Thr His Ser Arg Tyr Arg Cys Glu 
                645                 650                 655     


Arg Gln Arg Leu Ser Arg Ala Thr Ser Lys Leu Thr Ala Asp Tyr Lys 
            660                 665                 670         


Asn Ala Glu Arg Thr Asn Arg Phe Val Met Arg Glu Ile Asn Asp Arg 
        675                 680                 685             


Ile Met Arg Val Glu Tyr His Phe Leu Ser Pro Tyr Val Ser Pro Arg 
    690                 695                 700                 


Asp Ser Pro Phe Arg His Ile Phe Trp Gly Ser Gly Ser His Thr Leu 
705                 710                 715                 720 


Ser Ala Leu Leu Glu His Leu Lys Leu Arg Arg Glu Asn Asn Ser Ala 
                725                 730                 735     


Phe Asn Glu Thr Leu Leu Arg Asn Gln Leu Ala Leu Ala Thr Trp Thr 
            740                 745                 750         


Ile Gln Gly Ala Ala Asn Ala Leu Ser 
        755                 760     


<210>  13
<211>  2283
<212>  DNA
<213>  Calomys callosus

<400>  13
atgatggatc aagccagatc agcaatctct aacttgtttg gtggagaacc attatcatat       60

actcgattta gcctggctcg gcaagtagat ggagataata gccatgtgga gatgaaatta      120

gctgtagatg aagaagaaaa tgtggacaac atgaaggcca gcgtcagaaa acccagaagg      180

tttaatggga gactctgctt tgggacaatt gcagtagtca tctttttctt gattggattt      240

atgataggct atctgggata ttgtaaacgc atagaacaaa aagactgtgc aagaccggca      300

gaaatggaaa caatcaattc acaaaatctc caaccagaag aagacattcc taaatcttct      360

cgcttatatt gggcagacct caaaaagctg ttgtcagaga aactggatgc catagacttc      420

actgacacca tcaagcagct gagccaaaat acgtataccc ctcgggaggc tggatctcaa      480

aaagatgaaa atcttgccta ctatattgaa aatcaatttc atgacttaaa actcagcaaa      540

gtttggcgag atgaacatta tgtgaagctt caggtgaaaa gcagcgttgc tcaaaactca      600

gtgaccataa taaatgcaag taatggcgta tacctattgg agagtcctgc gggttatgtg      660

gcatatagca aagctgcaga agttactggt aaactggtcc atgctaattt tggcaccaaa      720

aaagactttg aaaacttaaa ttatgctgtg aatggatcct tagtgattgt tagagcagga      780

gaaattactt ttgcagaaaa ggttgcaaat gcccaaagcc ttaatgcaat tggtgtcttg      840

atatacatgg acaagaataa attcccagtt gttaaggcag acctttcact ctttggacat      900

gctcatctag gaactggtga cccatacaca cctggctttc catctttcaa ccatactcaa      960

tttccaccat ctcagtcatc aggattgcct agtatacctg ttcaaacaat ctcaagagag     1020

gctgcggaca acctatttca aaacatggag ggaaactgtc ctcctagttg gaacgtagat     1080

tcttcatgta agctagagtt gacttcagat aaaactgtga agctcgttgt gagaaatgaa     1140

ctgaaagaga caagaatact taacatcttt ggagttatta aaggttttga ggaaccagat     1200

cgttacattg tagtaggagc ccagagagat tcctggggtc ctggtgctgc aaagtccagt     1260

gtgggaacag ctcttctgtt gaaacttgcc cagacattct cagatatggt tttaagaggt     1320

ggatttaaac ccagcagaag cattatcttt gccagctgga ctgcaggaga ctttggagct     1380

gttggtgcca cggagtggct agagggatac ctttcatctc tgcatttaaa agccttcact     1440

tacattaatc tggataaagt tgtccttggt accagcaaat tcaaggtttc tgccagtcct     1500

ctgttatata cacttattga gaagacaatg caggacgtaa agcatccaat tgatgggaaa     1560

tctctgtatc gagacagcaa ctggatcagc aatgttaaga aactttcctt tgacaacgcc     1620

gctttccctt ttcttgcata ttctggaatc ccagcagttt ctttcagttt ttgtgaggat     1680

gaagactatc cttatttgga cacgattttg gatacctatg acctattgat tcagaaagtt     1740

cctcagctga acaaaatggt tcgtgtagct gcagaagtgg ctggtcagtt cattattaaa     1800

cttactcatg aaattgaact gaacctggac tacgatatgt ataacaacaa aatactgtca     1860

tttgtgaggg atctgaacca gttcagagcg gatatcaggg agatgggtct aagtctacag     1920

tggctgtatt ctgctcgtgg agactacttt cgtgctacat ctagactaac atctgacttc     1980

cataatgcgg agaaaacaaa cagatttgtc atgagggaaa tcaatgaccg tattatgaaa     2040

gtggaatacc acttcctgtc accttatgta tctcccagag agtctccttt ccgacacatc     2100

ttctggggtt atggttctca cacactctca gctttaatgg agaacttgaa gcttcggcag     2160

acaaatatta gtgcttttaa tgaaacgctc ttcagaaacc agttggccct agcttcttgg     2220

actatacagg gagttgcaaa tgccctctct ggtgacattt ggaatattga caatgagttt     2280

taa                                                                   2283


<210>  14
<211>  760
<212>  PRT
<213>  Calomys callosus

<400>  14

Met Met Asp Gln Ala Arg Ser Ala Ile Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Val 
        35                  40                  45              


Asp Asn Met Lys Ala Ser Val Arg Lys Pro Arg Arg Phe Asn Gly Arg 
    50                  55                  60                  


Leu Cys Phe Gly Thr Ile Ala Val Val Ile Phe Phe Leu Ile Gly Phe 
65                  70                  75                  80  


Met Ile Gly Tyr Leu Gly Tyr Cys Lys Arg Ile Glu Gln Lys Asp Cys 
                85                  90                  95      


Ala Arg Pro Ala Glu Met Glu Thr Ile Asn Ser Gln Asn Leu Gln Pro 
            100                 105                 110         


Glu Glu Asp Ile Pro Lys Ser Ser Arg Leu Tyr Trp Ala Asp Leu Lys 
        115                 120                 125             


Lys Leu Leu Ser Glu Lys Leu Asp Ala Ile Asp Phe Thr Asp Thr Ile 
    130                 135                 140                 


Lys Gln Leu Ser Gln Asn Thr Tyr Thr Pro Arg Glu Ala Gly Ser Gln 
145                 150                 155                 160 


Lys Asp Glu Asn Leu Ala Tyr Tyr Ile Glu Asn Gln Phe His Asp Leu 
                165                 170                 175     


Lys Leu Ser Lys Val Trp Arg Asp Glu His Tyr Val Lys Leu Gln Val 
            180                 185                 190         


Lys Ser Ser Val Ala Gln Asn Ser Val Thr Ile Ile Asn Ala Ser Asn 
        195                 200                 205             


Gly Val Tyr Leu Leu Glu Ser Pro Ala Gly Tyr Val Ala Tyr Ser Lys 
    210                 215                 220                 


Ala Ala Glu Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys 
225                 230                 235                 240 


Lys Asp Phe Glu Asn Leu Asn Tyr Ala Val Asn Gly Ser Leu Val Ile 
                245                 250                 255     


Val Arg Ala Gly Glu Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Gln 
            260                 265                 270         


Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Lys Asn Lys Phe 
        275                 280                 285             


Pro Val Val Lys Ala Asp Leu Ser Leu Phe Gly His Ala His Leu Gly 
    290                 295                 300                 


Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln 
305                 310                 315                 320 


Phe Pro Pro Ser Gln Ser Ser Gly Leu Pro Ser Ile Pro Val Gln Thr 
                325                 330                 335     


Ile Ser Arg Glu Ala Ala Asp Asn Leu Phe Gln Asn Met Glu Gly Asn 
            340                 345                 350         


Cys Pro Pro Ser Trp Asn Val Asp Ser Ser Cys Lys Leu Glu Leu Thr 
        355                 360                 365             


Ser Asp Lys Thr Val Lys Leu Val Val Arg Asn Glu Leu Lys Glu Thr 
    370                 375                 380                 


Arg Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Glu Glu Pro Asp 
385                 390                 395                 400 


Arg Tyr Ile Val Val Gly Ala Gln Arg Asp Ser Trp Gly Pro Gly Ala 
                405                 410                 415     


Ala Lys Ser Ser Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Thr 
            420                 425                 430         


Phe Ser Asp Met Val Leu Arg Gly Gly Phe Lys Pro Ser Arg Ser Ile 
        435                 440                 445             


Ile Phe Ala Ser Trp Thr Ala Gly Asp Phe Gly Ala Val Gly Ala Thr 
    450                 455                 460                 


Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr 
465                 470                 475                 480 


Tyr Ile Asn Leu Asp Lys Val Val Leu Gly Thr Ser Lys Phe Lys Val 
                485                 490                 495     


Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asp 
            500                 505                 510         


Val Lys His Pro Ile Asp Gly Lys Ser Leu Tyr Arg Asp Ser Asn Trp 
        515                 520                 525             


Ile Ser Asn Val Lys Lys Leu Ser Phe Asp Asn Ala Ala Phe Pro Phe 
    530                 535                 540                 


Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Ser Phe Cys Glu Asp 
545                 550                 555                 560 


Glu Asp Tyr Pro Tyr Leu Asp Thr Ile Leu Asp Thr Tyr Asp Leu Leu 
                565                 570                 575     


Ile Gln Lys Val Pro Gln Leu Asn Lys Met Val Arg Val Ala Ala Glu 
            580                 585                 590         


Val Ala Gly Gln Phe Ile Ile Lys Leu Thr His Glu Ile Glu Leu Asn 
        595                 600                 605             


Leu Asp Tyr Asp Met Tyr Asn Asn Lys Ile Leu Ser Phe Val Arg Asp 
    610                 615                 620                 


Leu Asn Gln Phe Arg Ala Asp Ile Arg Glu Met Gly Leu Ser Leu Gln 
625                 630                 635                 640 


Trp Leu Tyr Ser Ala Arg Gly Asp Tyr Phe Arg Ala Thr Ser Arg Leu 
                645                 650                 655     


Thr Ser Asp Phe His Asn Ala Glu Lys Thr Asn Arg Phe Val Met Arg 
            660                 665                 670         


Glu Ile Asn Asp Arg Ile Met Lys Val Glu Tyr His Phe Leu Ser Pro 
        675                 680                 685             


Tyr Val Ser Pro Arg Glu Ser Pro Phe Arg His Ile Phe Trp Gly Tyr 
    690                 695                 700                 


Gly Ser His Thr Leu Ser Ala Leu Met Glu Asn Leu Lys Leu Arg Gln 
705                 710                 715                 720 


Thr Asn Ile Ser Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala 
                725                 730                 735     


Leu Ala Ser Trp Thr Ile Gln Gly Val Ala Asn Ala Leu Ser Gly Asp 
            740                 745                 750         


Ile Trp Asn Ile Asp Asn Glu Phe 
        755                 760 


<210>  15
<211>  760
<212>  PRT
<213>  homo sapiens

<400>  15

Met Met Asp Gln Ala Arg Ser Ala Ile Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Val 
        35                  40                  45              


Asp Asn Met Lys Ala Ser Val Arg Lys Pro Arg Arg Phe Asn Gly Arg 
    50                  55                  60                  


Leu Cys Phe Gly Thr Ile Ala Val Val Ile Phe Phe Leu Ile Gly Phe 
65                  70                  75                  80  


Met Ile Gly Tyr Leu Gly Tyr Cys Lys Arg Ile Glu Gln Lys Asp Cys 
                85                  90                  95      


Ala Arg Pro Ala Glu Met Glu Thr Ile Asn Ser Gln Asn Leu Gln Pro 
            100                 105                 110         


Glu Glu Asp Ile Pro Lys Ser Ser Arg Leu Tyr Trp Ala Asp Leu Lys 
        115                 120                 125             


Lys Leu Leu Ser Glu Lys Leu Asp Ala Ile Asp Phe Thr Asp Thr Ile 
    130                 135                 140                 


Lys Gln Leu Ser Gln Asn Thr Tyr Thr Pro Arg Glu Ala Gly Ser Gln 
145                 150                 155                 160 


Lys Asp Glu Asn Leu Ala Tyr Tyr Ile Glu Asn Gln Phe His Asp Leu 
                165                 170                 175     


Lys Leu Ser Lys Val Trp Arg Asp Glu His Tyr Val Lys Leu Gln Val 
            180                 185                 190         


Lys Ser Ser Val Ala Gln Asn Ser Val Thr Ile Ile Asn Ala Ser Asn 
        195                 200                 205             


Gly Val Tyr Leu Leu Glu Ser Pro Ala Gly Tyr Val Ala Tyr Ser Lys 
    210                 215                 220                 


Ala Ala Glu Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys 
225                 230                 235                 240 


Lys Asp Phe Glu Asn Leu Asn Tyr Ala Val Asn Gly Ser Leu Val Ile 
                245                 250                 255     


Val Arg Ala Gly Glu Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Gln 
            260                 265                 270         


Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Lys Asn Lys Phe 
        275                 280                 285             


Pro Val Val Lys Ala Asp Leu Ser Leu Phe Gly His Ala His Leu Gly 
    290                 295                 300                 


Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln 
305                 310                 315                 320 


Phe Pro Pro Ser Gln Ser Ser Gly Leu Pro Ser Ile Pro Val Gln Thr 
                325                 330                 335     


Ile Ser Arg Glu Ala Ala Asp Asn Leu Phe Gln Asn Met Glu Gly Asn 
            340                 345                 350         


Cys Pro Pro Ser Trp Asn Val Asp Ser Ser Cys Lys Leu Glu Leu Thr 
        355                 360                 365             


Ser Asp Lys Thr Val Lys Leu Val Val Arg Asn Glu Leu Lys Glu Thr 
    370                 375                 380                 


Arg Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Glu Glu Pro Asp 
385                 390                 395                 400 


Arg Tyr Ile Val Val Gly Ala Gln Arg Asp Ser Trp Gly Pro Gly Ala 
                405                 410                 415     


Ala Lys Ser Ser Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Thr 
            420                 425                 430         


Phe Ser Asp Met Val Leu Arg Gly Gly Phe Lys Pro Ser Arg Ser Ile 
        435                 440                 445             


Ile Phe Ala Ser Trp Thr Ala Gly Asp Phe Gly Ala Val Gly Ala Thr 
    450                 455                 460                 


Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr 
465                 470                 475                 480 


Tyr Ile Asn Leu Asp Lys Val Val Leu Gly Thr Ser Lys Phe Lys Val 
                485                 490                 495     


Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asp 
            500                 505                 510         


Val Lys His Pro Ile Asp Gly Lys Ser Leu Tyr Arg Asp Ser Asn Trp 
        515                 520                 525             


Ile Ser Asn Val Lys Lys Leu Ser Phe Asp Asn Ala Ala Phe Pro Phe 
    530                 535                 540                 


Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Ser Phe Cys Glu Asp 
545                 550                 555                 560 


Glu Asp Tyr Pro Tyr Leu Asp Thr Ile Leu Asp Thr Tyr Asp Leu Leu 
                565                 570                 575     


Ile Gln Lys Val Pro Gln Leu Asn Lys Met Val Arg Val Ala Ala Glu 
            580                 585                 590         


Val Ala Gly Gln Phe Ile Ile Lys Leu Thr His Glu Ile Glu Leu Asn 
        595                 600                 605             


Leu Asp Tyr Asp Met Tyr Asn Asn Lys Ile Leu Ser Phe Val Arg Asp 
    610                 615                 620                 


Leu Asn Gln Phe Arg Ala Asp Ile Arg Glu Met Gly Leu Ser Leu Gln 
625                 630                 635                 640 


Trp Leu Tyr Ser Ala Arg Gly Asp Tyr Phe Arg Ala Thr Ser Arg Leu 
                645                 650                 655     


Thr Ser Asp Phe His Asn Ala Glu Lys Thr Asn Arg Phe Val Met Arg 
            660                 665                 670         


Glu Ile Asn Asp Arg Ile Met Lys Val Glu Tyr His Phe Leu Ser Pro 
        675                 680                 685             


Tyr Val Ser Pro Arg Glu Ser Pro Phe Arg His Ile Phe Trp Gly Tyr 
    690                 695                 700                 


Gly Ser His Thr Leu Ser Ala Leu Met Glu Asn Leu Lys Leu Arg Gln 
705                 710                 715                 720 


Thr Asn Ile Ser Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala 
                725                 730                 735     


Leu Ala Ser Trp Thr Ile Gln Gly Val Ala Asn Ala Leu Ser Gly Asp 
            740                 745                 750         


Ile Trp Asn Ile Asp Asn Glu Phe 
        755                 760 


<210>  16
<211>  587
<212>  DNA
<213>  homo sapiens

<400>  16
aagattcagg tcaaagacag cgctcaaaac tcggtgatca tagttgataa gaacggtaga       60

cttgtttacc tggtggagaa tcctgggggt tatgtggcgt atagtaaggc tgcaacagtt      120

actggtaaac tggtccatgc taattttggt actaaaaaag attttgagga tttatacact      180

cctgtgaatg gatctatagt gattgtcaga gcagggaaaa tcacctttgc agaaaaggtt      240

gcaaatgctg aaagcttaaa tgcaattggt gtgttgatat acatggacca gactaaattt      300

cccattgtta acgcagaact ttcattcttt ggacatgctc atctggggac aggtgaccct      360

tacacacctg gattcccttc cttcaatcac actcagtttc caccatctcg gtcatcagga      420

ttgcctaata tacctgtcca gacaatctcc agagctgctg cagaaaagct gtttgggaat      480

atggaaggag actgtccctc tgactggaaa acagactcta catgtaggat ggtaacctca      540

gaaagcaaga atgtgaagct cactgtgagc aatgtgctga aagagat                    587


<210>  17
<211>  195
<212>  PRT
<213>  neotoma albigula

<400>  17

Lys Ile Gln Val Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp 
1               5                   10                  15      


Lys Asn Gly Arg Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val 
            20                  25                  30          


Ala Tyr Ser Lys Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn 
        35                  40                  45              


Phe Gly Thr Lys Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly 
    50                  55                  60                  


Ser Ile Val Ile Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val 
65                  70                  75                  80  


Ala Asn Ala Glu Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp 
                85                  90                  95      


Gln Thr Lys Phe Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His 
            100                 105                 110         


Ala His Leu Gly Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe 
        115                 120                 125             


Asn His Thr Gln Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile 
    130                 135                 140                 


Pro Val Gln Thr Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn 
145                 150                 155                 160 


Met Glu Gly Asp Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg 
                165                 170                 175     


Met Val Thr Ser Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val 
            180                 185                 190         


Leu Lys Glu 
        195 


<210>  18
<211>  587
<212>  DNA
<213>  neotoma albigula

<400>  18
aagatccagg tgaaaggcag cgttgctcca aactcggtga ccataacaaa tgcaagtggt       60

ggcttgtacc tagtggagta tcctgagggt tatgtggcgt atagtaaagc tacagaagtt      120

actggtaaac tggtccatgc taattttggc actaaaaagg actttgaaga tttagattat      180

gctgtgaatg gatctatagt gattgttaga gcagggaaaa tcactattgc agaaaaggtt      240

gcaaatgccc aaagctttaa tgcaattggt gtcctgatat acatggacag gactaagttc      300

cccattgtta gggcagacat tccactcttt ggacatgctc atctaggaac cggtgaccca      360

tacacacctg gctttccatc tttcaaccat actcagtttc cgccatccca atcatcagga      420

ttgcctagta tacctgttca aacaatctca agagaggctg cagaaaagct atttcagaac      480

atggaaagag actgtcctcg tagttggaac acagattctt cctgtaagct ggaattgtta      540

cagaacagaa atgtgaagct cactgtgaac aatgcactga aagaaac                    587


<210>  19
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of signal peptide for expression of sAD and 
       arenacept

<400>  19

Gly Leu Cys Cys Val Leu Leu Leu Cys Gly Ala Val Phe Val Ser Pro 
1               5                   10                  15      


Ala Gly Ala 
            


<210>  20
<211>  2277
<212>  DNA
<213>  Sigmodon hispidus

<400>  20
atgatggatc aagccagatc agcaatctct aacttgtttg gtggagaacc attatcatat       60

acccggttta gcctggctcg gcaagcagat ggagataaca gccatgtgga gatgaaattg      120

gctgtagatg aagaagaaaa tatggacaac atgaaggcta gtgtcagaaa acccagaaaa      180

tttaatggaa gactctgctt tgggacagtt gcagtagtca tctttttctt aattggattt      240

atgactggct acctggggta ctgtaaacgc atagaacaaa aagactgtgt gaaagtggca      300

gaagcggaga cagtcaattc acagaacttc caaacagaag aagacattcc taaatcttct      360

cgcttgtatt gggcagacct caaaaaactg ttgtcagaga aactgaacac catagagttc      420

acagacacca tcaagcagct gagccagaat acccctcggg aggctggatc tcaaaaagat      480

gaaaatcttg cctattatat tgaaaatcag tttcaagact ttaaactcag caaagtctgg      540

cgagatgaac attatgtgaa gatccaggtg aaaggcagca atgctcaaaa ctcggtgacc      600

ataataaatg ataatggtgg cttgtacctg ttgaagaatc ttacaggtta tgtggcatat      660

agcaaagctg cagaagttac tggtaaactg gtccatgcta attttggcac taaaaaagac      720

tttgaaaact taaattatgc tgtgaatgga tccttagtga ttgttagagc aggggaaatc      780

acttttgcag aaaaggttgc aaatgcacaa agctttaatg caattggtgt cttgatatac      840

atggacaaga ataaattccc agttgttaag gcagaccttg cacgttttgg acatgctcat      900

ctaggaactg gtgacccata cacacctggc tttccatctt tcaatcatac tcagtttccg      960

ccatctcagt catcgggatt gcctaggata cctgttcaaa caatttcaag agaggctgct     1020

gacaagctat ttcaaaacat ggaaggaaag tgcccttcta gttggaacgt agattcttca     1080

tgtaaactgg aattgacatc agataaaaat gtgaagctca gtgtgaacaa cgagttgaaa     1140

gagacaagaa tacttaatat ctttggcgtt attaaaggtt ttgaggaacc agaccgttac     1200

gttgtagtag gagcccagag agattcctgg ggtcctggtg ctgcaaagtc cagtgtggga     1260

acagctcttc tgttgaaact tgcccaaaca ttttcagata tggttttaag aggtggattt     1320

aaacccatta ggagcattat ctttgccagc tggactgcag gagacttcgg agctgttggt     1380

gccaccgagt ggctagaggg atacctttca tctctgcaca taaaagcctt cacttacatt     1440

aatctggata aagttgtcct tggtactaac aacttcaaag tttctgctag ccctctattg     1500

tatacactta ttgagaagac aatgcaggat gtaaagcatc caattgatgg gagatctcta     1560

tatcgagaca gcaactggat caacaaagtt gagaaacttt cccttgacaa tgccgccttc     1620

ccttttctgg catattctgg aatcccagca gtttctttct gtttttgtga ggatgaggat     1680

tatccttatt tggatactat gctggatacg tatgagttac taattcagaa agttcctcag     1740

ctggacaaaa tggttcgtgt agctgcagaa gtggctggtc agttcattat taaacttact     1800

catgaaattg aactgaacct ggactatgat atgtataaca acaaaatact gtcatttgtg     1860

agggatctga accagttccg agcagatatc agggacatgg gtctaagtct acagtggctg     1920

tattctgctc gcggagacta ctttcgtgct acatctagac taacatctga cttccataat     1980

gcggagaaaa caaacagatt tgtcatgagg caaatcaatg accgtattat gaaagtagaa     2040

tatcacttcc tgtcacccta tgtatctccc agagagtctc cttttcgaca catcttctgg     2100

ggttatggct ctcacactct ttcagcttta atggagagtt tgaagcttcg acagaaaaat     2160

attagcgctt ttaatgaaac actcttcaga aaccagttgg ccttagcttc gtggactatt     2220

caaggagttg caaatgccct ctctggtgac atttggaata ttgacaatga gttttaa        2277


<210>  21
<211>  758
<212>  PRT
<213>  Sigmodon hispidus

<400>  21

Met Met Asp Gln Ala Arg Ser Ala Ile Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Ala Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Met 
        35                  40                  45              


Asp Asn Met Lys Ala Ser Val Arg Lys Pro Arg Lys Phe Asn Gly Arg 
    50                  55                  60                  


Leu Cys Phe Gly Thr Val Ala Val Val Ile Phe Phe Leu Ile Gly Phe 
65                  70                  75                  80  


Met Thr Gly Tyr Leu Gly Tyr Cys Lys Arg Ile Glu Gln Lys Asp Cys 
                85                  90                  95      


Val Lys Val Ala Glu Ala Glu Thr Val Asn Ser Gln Asn Phe Gln Thr 
            100                 105                 110         


Glu Glu Asp Ile Pro Lys Ser Ser Arg Leu Tyr Trp Ala Asp Leu Lys 
        115                 120                 125             


Lys Leu Leu Ser Glu Lys Leu Asn Thr Ile Glu Phe Thr Asp Thr Ile 
    130                 135                 140                 


Lys Gln Leu Ser Gln Asn Thr Pro Arg Glu Ala Gly Ser Gln Lys Asp 
145                 150                 155                 160 


Glu Asn Leu Ala Tyr Tyr Ile Glu Asn Gln Phe Gln Asp Phe Lys Leu 
                165                 170                 175     


Ser Lys Val Trp Arg Asp Glu His Tyr Val Lys Ile Gln Val Lys Gly 
            180                 185                 190         


Ser Asn Ala Gln Asn Ser Val Thr Ile Ile Asn Asp Asn Gly Gly Leu 
        195                 200                 205             


Tyr Leu Leu Lys Asn Leu Thr Gly Tyr Val Ala Tyr Ser Lys Ala Ala 
    210                 215                 220                 


Glu Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys Lys Asp 
225                 230                 235                 240 


Phe Glu Asn Leu Asn Tyr Ala Val Asn Gly Ser Leu Val Ile Val Arg 
                245                 250                 255     


Ala Gly Glu Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Gln Ser Phe 
            260                 265                 270         


Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Lys Asn Lys Phe Pro Val 
        275                 280                 285             


Val Lys Ala Asp Leu Ala Arg Phe Gly His Ala His Leu Gly Thr Gly 
    290                 295                 300                 


Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln Phe Pro 
305                 310                 315                 320 


Pro Ser Gln Ser Ser Gly Leu Pro Arg Ile Pro Val Gln Thr Ile Ser 
                325                 330                 335     


Arg Glu Ala Ala Asp Lys Leu Phe Gln Asn Met Glu Gly Lys Cys Pro 
            340                 345                 350         


Ser Ser Trp Asn Val Asp Ser Ser Cys Lys Leu Glu Leu Thr Ser Asp 
        355                 360                 365             


Lys Asn Val Lys Leu Ser Val Asn Asn Glu Leu Lys Glu Thr Arg Ile 
    370                 375                 380                 


Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Glu Glu Pro Asp Arg Tyr 
385                 390                 395                 400 


Val Val Val Gly Ala Gln Arg Asp Ser Trp Gly Pro Gly Ala Ala Lys 
                405                 410                 415     


Ser Ser Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Thr Phe Ser 
            420                 425                 430         


Asp Met Val Leu Arg Gly Gly Phe Lys Pro Ile Arg Ser Ile Ile Phe 
        435                 440                 445             


Ala Ser Trp Thr Ala Gly Asp Phe Gly Ala Val Gly Ala Thr Glu Trp 
    450                 455                 460                 


Leu Glu Gly Tyr Leu Ser Ser Leu His Ile Lys Ala Phe Thr Tyr Ile 
465                 470                 475                 480 


Asn Leu Asp Lys Val Val Leu Gly Thr Asn Asn Phe Lys Val Ser Ala 
                485                 490                 495     


Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asp Val Lys 
            500                 505                 510         


His Pro Ile Asp Gly Arg Ser Leu Tyr Arg Asp Ser Asn Trp Ile Asn 
        515                 520                 525             


Lys Val Glu Lys Leu Ser Leu Asp Asn Ala Ala Phe Pro Phe Leu Ala 
    530                 535                 540                 


Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp Glu Asp 
545                 550                 555                 560 


Tyr Pro Tyr Leu Asp Thr Met Leu Asp Thr Tyr Glu Leu Leu Ile Gln 
                565                 570                 575     


Lys Val Pro Gln Leu Asp Lys Met Val Arg Val Ala Ala Glu Val Ala 
            580                 585                 590         


Gly Gln Phe Ile Ile Lys Leu Thr His Glu Ile Glu Leu Asn Leu Asp 
        595                 600                 605             


Tyr Asp Met Tyr Asn Asn Lys Ile Leu Ser Phe Val Arg Asp Leu Asn 
    610                 615                 620                 


Gln Phe Arg Ala Asp Ile Arg Asp Met Gly Leu Ser Leu Gln Trp Leu 
625                 630                 635                 640 


Tyr Ser Ala Arg Gly Asp Tyr Phe Arg Ala Thr Ser Arg Leu Thr Ser 
                645                 650                 655     


Asp Phe His Asn Ala Glu Lys Thr Asn Arg Phe Val Met Arg Gln Ile 
            660                 665                 670         


Asn Asp Arg Ile Met Lys Val Glu Tyr His Phe Leu Ser Pro Tyr Val 
        675                 680                 685             


Ser Pro Arg Glu Ser Pro Phe Arg His Ile Phe Trp Gly Tyr Gly Ser 
    690                 695                 700                 


His Thr Leu Ser Ala Leu Met Glu Ser Leu Lys Leu Arg Gln Lys Asn 
705                 710                 715                 720 


Ile Ser Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala Leu Ala 
                725                 730                 735     


Ser Trp Thr Ile Gln Gly Val Ala Asn Ala Leu Ser Gly Asp Ile Trp 
            740                 745                 750         


Asn Ile Asp Asn Glu Phe 
        755             


<210>  22
<211>  1053
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of  S206A ARENACEPT

<400>  22
ggatccaaga ttcaggtcaa atgttcagct cctaactctg tcacaattac taacgcagca       60

ggcggactgt atctggtgga ataccccgag ggctacgtgg cctattctaa ggccaccgag      120

gtgacaggca agctggtgca cgccaacttc ggcaccaaga aggactttga ggacctggat      180

tacgccgtga atggctccat cgtgatcgtg cgggccggca agatcaccat cgccgagaag      240

gtggccaacg cccagtcctt caatgccatc ggcgtgctga tctacaagga caggacaaag      300

tatccaatct ctagggcaga tgagccactg cagggacact ctggcctgcc aagcatccct      360

gtgcagacca tcagcaggga ggcagcagag aagctgtttc agaacatgga gcgggactgc      420

cccagatcct ggaatacaga tagctcctgt aagctggagc tgctgcagaa caggaatgtg      480

aagctgaccg tgaataactg cctgaaggag ggtaccgaga acttgtactt ccagggtagt      540

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      600

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      660

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      720

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      780

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      840

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      900

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag      960

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1020

tgggagagca atgggcagcc ggagaacaac tac                                  1053


<210>  23
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of  S206A ARENACEPT

<400>  23

Gly Ser Lys Ile Gln Val Lys Cys Ser Ala Pro Asn Ser Val Thr Ile 
1               5                   10                  15      


Thr Asn Ala Ala Gly Gly Leu Tyr Leu Val Glu Tyr Pro Glu Gly Tyr 
            20                  25                  30          


Val Ala Tyr Ser Lys Ala Thr Glu Val Thr Gly Lys Leu Val His Ala 
        35                  40                  45              


Asn Phe Gly Thr Lys Lys Asp Phe Glu Asp Leu Asp Tyr Ala Val Asn 
    50                  55                  60                  


Gly Ser Ile Val Ile Val Arg Ala Gly Lys Ile Thr Ile Ala Glu Lys 
65                  70                  75                  80  


Val Ala Asn Ala Gln Ser Phe Asn Ala Ile Gly Val Leu Ile Tyr Lys 
                85                  90                  95      


Asp Arg Thr Lys Tyr Pro Ile Ser Arg Ala Asp Glu Pro Leu Gln Gly 
            100                 105                 110         


His Ser Gly Leu Pro Ser Ile Pro Val Gln Thr Ile Ser Arg Glu Ala 
        115                 120                 125             


Ala Glu Lys Leu Phe Gln Asn Met Glu Arg Asp Cys Pro Arg Ser Trp 
    130                 135                 140                 


Asn Thr Asp Ser Ser Cys Lys Leu Glu Leu Leu Gln Asn Arg Asn Val 
145                 150                 155                 160 


Lys Leu Thr Val Asn Asn Cys Leu Lys Glu Gly Thr Glu Asn Leu Tyr 
                165                 170                 175     


Phe Gln Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            180                 185                 190         


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        195                 200                 205             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    210                 215                 220                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
225                 230                 235                 240 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                245                 250                 255     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            260                 265                 270         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        275                 280                 285             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    290                 295                 300                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
305                 310                 315                 320 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                325                 330                 335     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            340                 345                 350         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        355                 360                 365             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    370                 375                 380                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
385                 390                 395                 400 


Leu Ser Leu Ser Pro Gly Lys 
                405         


