                         SEQUENCE LISTING

<110>  UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF
       HIGHER EDUCATION
 
<120>  OPTOGENETIC INDUCTION OF MEMBRANELESS ORGANELLES

<130>  10504-020WO1

<160>  110   

<170>  PatentIn version 3.5

<210>  1
<211>  498
<212>  PRT
<213>  Arabidopsis

<400>  1

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Glu Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala 
        


<210>  2
<211>  498
<212>  PRT
<213>  Arabidopsis

<400>  2

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala 
        


<210>  3
<211>  119
<212>  PRT
<213>  Neurospora crassa

<400>  3

Met Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr 
1               5                   10                  15      


Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
            20                  25                  30          


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
        35                  40                  45              


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
    50                  55                  60                  


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
65                  70                  75                  80  


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
                85                  90                  95      


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
            100                 105                 110         


Gly Phe Gln Cys Glu Thr Glu 
        115                 


<210>  4
<211>  151
<212>  PRT
<213>  Neurospora crassa

<400>  4

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Tyr Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu 
145                 150     


<210>  5
<211>  151
<212>  PRT
<213>  Neurospora crassa

<400>  5

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu 
145                 150     


<210>  6
<211>  348
<212>  PRT
<213>  Vaucheria frigida

<400>  6

Met Asn Gly Leu Thr Pro Pro Leu Met Phe Cys Ser Arg Ser Asp Asp 
1               5                   10                  15      


Pro Ser Ser Thr Ser Asn Ile Asn Leu Asp Asp Val Phe Ala Asp Val 
            20                  25                  30          


Phe Phe Asn Ser Asn Gly Glu Leu Leu Asp Ile Asp Glu Ile Asp Asp 
        35                  40                  45              


Phe Gly Asp Asn Thr Cys Pro Lys Ser Ser Met Ser Val Asp Asp Asp 
    50                  55                  60                  


Ala Ser Ser Gln Val Phe Gln Gly His Leu Phe Gly Asn Ala Leu Ser 
65                  70                  75                  80  


Ser Ile Ala Leu Ser Asp Ser Gly Asp Leu Ser Thr Gly Ile Tyr Glu 
                85                  90                  95      


Ser Gln Gly Asn Ala Ser Arg Gly Lys Ser Leu Arg Thr Lys Ser Ser 
            100                 105                 110         


Gly Ser Ile Ser Ser Glu Leu Thr Glu Ala Gln Lys Val Glu Arg Arg 
        115                 120                 125             


Glu Arg Asn Arg Glu His Ala Lys Arg Ser Arg Val Arg Lys Lys Phe 
    130                 135                 140                 


Leu Leu Glu Ser Leu Gln Gln Ser Val Asn Glu Leu Asn His Glu Asn 
145                 150                 155                 160 


Asn Cys Leu Lys Glu Ser Ile Arg Glu His Leu Gly Pro Arg Gly Asp 
                165                 170                 175     


Ser Leu Ile Ala Gln Cys Ser Pro Glu Ala Asp Thr Leu Leu Thr Asp 
            180                 185                 190         


Asn Pro Ser Lys Ala Asn Arg Ile Leu Glu Asp Pro Asp Tyr Ser Leu 
        195                 200                 205             


Val Lys Ala Leu Gln Met Ala Gln Gln Asn Phe Val Ile Thr Asp Ala 
    210                 215                 220                 


Ser Leu Pro Asp Asn Pro Ile Val Tyr Ala Ser Arg Gly Phe Leu Thr 
225                 230                 235                 240 


Leu Thr Gly Tyr Ser Leu Asp Gln Ile Leu Gly Arg Asn Cys Arg Phe 
                245                 250                 255     


Leu Gln Gly Pro Glu Thr Asp Pro Arg Ala Val Asp Lys Ile Arg Asn 
            260                 265                 270         


Ala Ile Thr Lys Gly Val Asp Thr Ser Val Cys Leu Leu Asn Tyr Arg 
        275                 280                 285             


Gln Asp Gly Thr Thr Phe Trp Asn Leu Phe Phe Val Ala Gly Leu Arg 
    290                 295                 300                 


Asp Ser Lys Gly Asn Ile Val Asn Tyr Val Gly Val Gln Ser Lys Val 
305                 310                 315                 320 


Ser Glu Asp Tyr Ala Lys Leu Leu Val Asn Glu Gln Asn Ile Glu Tyr 
                325                 330                 335     


Lys Gly Val Arg Thr Ser Asn Met Leu Arg Arg Lys 
            340                 345             


<210>  7
<211>  145
<212>  PRT
<213>  Vaucheria frigida

<400>  7

Pro Asp Tyr Ser Leu Val Lys Ala Leu Gln Met Ala Gln Gln Asn Phe 
1               5                   10                  15      


Val Ile Thr Asp Ala Ser Leu Pro Asp Asn Pro Ile Val Tyr Ala Ser 
            20                  25                  30          


Arg Gly Phe Leu Thr Leu Thr Gly Tyr Ser Leu Asp Gln Ile Leu Gly 
        35                  40                  45              


Arg Asn Cys Arg Phe Leu Gln Gly Pro Glu Thr Asp Pro Arg Ala Val 
    50                  55                  60                  


Asp Lys Ile Arg Asn Ala Ile Thr Lys Gly Val Asp Thr Ser Val Cys 
65                  70                  75                  80  


Leu Leu Asn Tyr Arg Gln Asp Gly Thr Thr Phe Trp Asn Leu Phe Phe 
                85                  90                  95      


Val Ala Gly Leu Arg Asp Ser Lys Gly Asn Ile Val Asn Tyr Val Gly 
            100                 105                 110         


Val Gln Ser Lys Val Ser Glu Asp Tyr Ala Lys Leu Leu Val Asn Glu 
        115                 120                 125             


Gln Asn Ile Glu Tyr Lys Gly Val Arg Thr Ser Asn Met Leu Arg Arg 
    130                 135                 140                 


Lys 
145 


<210>  8
<211>  435
<212>  DNA
<213>  Vaucheria frigida

<400>  8
cctgactaca gtctcgtgaa ggctctgcaa atggcacaac agaattttgt cattacagac       60

gcctccctcc cagacaaccc tatcgtctac gccagtagag ggtttctgac actgacaggc      120

tattctctcg accagatcct gggcaggaac tgcaggtttc tgcaagggcc agaaacagac      180

ccaagagctg tggataagat caggaatgcc atcaccaaag gcgttgatac cagtgtctgt      240

ctgctgaatt atagacagga tggcacaacc ttctggaatc tcttcttcgt ggctggactc      300

agagattcta agggcaatat tgtcaactac gtcggagtgc agtcaaaggt gagcgaagat      360

tatgccaagc tgctggtcaa cgagcagaac attgagtaca aaggtgtgcg caccagtaac      420

atgctgcgca gaaag                                                       435


<210>  9
<211>  653
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Met Val Met Glu Lys Pro Ser Pro Leu 
145                 150                 155                 160 


Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln 
                165                 170                 175     


Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val 
            180                 185                 190         


His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly 
        195                 200                 205             


Gln Lys Glu Ile His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys 
    210                 215                 220                 


His Thr Lys Ile Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly 
225                 230                 235                 240 


Val Val Val Gln Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu 
                245                 250                 255     


Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala 
            260                 265                 270         


Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val 
        275                 280                 285             


Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val 
    290                 295                 300                 


Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp 
305                 310                 315                 320 


Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu 
                325                 330                 335     


His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu 
            340                 345                 350         


Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro 
        355                 360                 365             


Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro 
    370                 375                 380                 


Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe 
385                 390                 395                 400 


Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val 
                405                 410                 415     


Pro Val Thr Gly Ile Pro Pro His Val Val Lys Val Pro Ala Ser Gln 
            420                 425                 430         


Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro 
        435                 440                 445             


Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln 
    450                 455                 460                 


Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu 
465                 470                 475                 480 


Pro Arg Arg Met Val Arg His Pro Asp Ser His Gln Leu Phe Ile Gly 
                485                 490                 495     


Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln 
            500                 505                 510         


Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu 
        515                 520                 525             


Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys 
    530                 535                 540                 


Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn 
545                 550                 555                 560 


Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp 
                565                 570                 575     


Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly 
            580                 585                 590         


Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly Phe Gly 
        595                 600                 605             


Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met Ala Arg 
    610                 615                 620                 


Arg Ala Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu Ile Val 
625                 630                 635                 640 


Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala 
                645                 650             


<210>  10
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Met Gly Phe Val Thr Glu Pro Gln Glu 
145                 150                 155                 160 


Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro 
                165                 170                 175     


Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val 
            180                 185                 190         


Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu 
        195                 200                 205             


Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln 
    210                 215                 220                 


Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro Glu Asp Ala 
225                 230                 235                 240 


Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln 
                245                 250                 255     


Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu 
            260                 265                 270         


Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val 
        275                 280                 285             


Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln 
    290                 295                 300                 


Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg 
305                 310                 315                 320 


Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly 
                325                 330                 335     


Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser 
            340                 345                 350         


His Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu 
        355                 360                 365             


Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile 
    370                 375                 380                 


Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp 
385                 390                 395                 400 


Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg 
                405                 410                 415     


Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg 
            420                 425                 430         


Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg 
        435                 440                 445             


Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val 
    450                 455                 460                 


Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys 
465                 470                 475                 480 


Leu Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys 
                485                 490                 495     


Phe Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu 
            500                 505                 510         


Pro Glu Ala 
        515 


<210>  11
<211>  571
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Met Val Met Glu Lys Pro Ser Pro Leu 
145                 150                 155                 160 


Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln 
                165                 170                 175     


Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val 
            180                 185                 190         


His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly 
        195                 200                 205             


Gln Lys Glu Ile His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys 
    210                 215                 220                 


His Thr Lys Ile Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly 
225                 230                 235                 240 


Val Val Val Gln Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu 
                245                 250                 255     


Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala 
            260                 265                 270         


Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val 
        275                 280                 285             


Phe Gly Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro 
    290                 295                 300                 


Ala Asp Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp 
305                 310                 315                 320 


Ala Ser Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val 
                325                 330                 335     


Thr Gly Ile Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg 
            340                 345                 350         


Pro Glu Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg 
        355                 360                 365             


Asp Gln Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly 
    370                 375                 380                 


Pro Arg Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg 
385                 390                 395                 400 


Arg Met Val Arg His Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu 
                405                 410                 415     


Pro His Glu Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr 
            420                 425                 430         


Gly Asn Val Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn 
        435                 440                 445             


Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu 
    450                 455                 460                 


Ser Asn Arg Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu 
465                 470                 475                 480 


Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg 
                485                 490                 495     


Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg 
            500                 505                 510         


Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly 
        515                 520                 525             


Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala 
    530                 535                 540                 


Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg 
545                 550                 555                 560 


Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala 
                565                 570     


<210>  12
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Met Val Met Glu Lys Pro Ser Pro Leu 
145                 150                 155                 160 


Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln 
                165                 170                 175     


Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val 
            180                 185                 190         


His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly 
        195                 200                 205             


Gln Lys Glu Ile His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys 
    210                 215                 220                 


His Thr Lys Ile Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly 
225                 230                 235                 240 


Val Val Val Gln Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu 
                245                 250                 255     


Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala 
            260                 265                 270         


Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val 
        275                 280                 285             


Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val 
    290                 295                 300                 


Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp 
305                 310                 315                 320 


Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu 
                325                 330                 335     


His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu 
            340                 345                 350         


Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro 
        355                 360                 365             


Val Leu Glu Glu Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp 
    370                 375                 380                 


Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu 
385                 390                 395                 400 


Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val 
                405                 410                 415     


Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile 
            420                 425                 430         


Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg 
        435                 440                 445             


Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly 
    450                 455                 460                 


Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly 
465                 470                 475                 480 


Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro 
                485                 490                 495     


Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly 
            500                 505                 510         


His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr 
        515                 520                 525             


Thr Tyr Glu Pro Glu Ala 
    530                 


<210>  13
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  13

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Met Val Met Glu Lys Pro Ser Pro Leu 
145                 150                 155                 160 


Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln 
                165                 170                 175     


Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val 
            180                 185                 190         


His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly 
        195                 200                 205             


Gln Lys Glu Ile His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys 
    210                 215                 220                 


His Thr Lys Ile Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly 
225                 230                 235                 240 


Val Val Val Gln Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu 
                245                 250                 255     


Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala 
            260                 265                 270         


Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val 
        275                 280                 285             


Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val 
    290                 295                 300                 


Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp 
305                 310                 315                 320 


Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu 
                325                 330                 335     


His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu 
            340                 345                 350         


Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro 
        355                 360                 365             


Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro 
    370                 375                 380                 


Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe 
385                 390                 395                 400 


Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val 
                405                 410                 415     


Pro Val Thr Gly Ile Pro Pro His Val Val Lys Val Pro Ala Ser Gln 
            420                 425                 430         


Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro 
        435                 440                 445             


Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln 
    450                 455                 460                 


Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu 
465                 470                 475                 480 


Pro Arg Arg Met Val Arg His Pro Asp Ser His Glu Lys Lys Thr Arg 
                485                 490                 495     


Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly 
            500                 505                 510         


Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly 
        515                 520                 525             


Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro 
    530                 535                 540                 


Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly 
545                 550                 555                 560 


His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr 
                565                 570                 575     


Thr Tyr Glu Pro Glu Ala 
            580         


<210>  14
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  14

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Met Val Met Glu Lys Pro Ser Pro Leu 
145                 150                 155                 160 


Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln 
                165                 170                 175     


Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val 
            180                 185                 190         


His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly 
        195                 200                 205             


Gln Lys Glu Ile His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys 
    210                 215                 220                 


His Thr Lys Ile Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly 
225                 230                 235                 240 


Val Val Val Gln Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu 
                245                 250                 255     


Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala 
            260                 265                 270         


Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val 
        275                 280                 285             


Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val 
    290                 295                 300                 


Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp 
305                 310                 315                 320 


Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu 
                325                 330                 335     


His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu 
            340                 345                 350         


Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro 
        355                 360                 365             


Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro 
    370                 375                 380                 


Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe 
385                 390                 395                 400 


Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val 
                405                 410                 415     


Pro Val Thr Gly Ile Pro Pro His Val Val Lys Val Pro Ala Ser Gln 
            420                 425                 430         


Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro 
        435                 440                 445             


Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln 
    450                 455                 460                 


Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu 
465                 470                 475                 480 


Pro Arg Arg Met Val Arg His Pro Asp Ser His Gln Leu Phe Ile Gly 
                485                 490                 495     


Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln 
            500                 505                 510         


Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu 
        515                 520                 525             


Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys 
    530                 535                 540                 


Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn 
545                 550                 555                 560 


Val Glu 
        


<210>  15
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  15

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Met Val Met Glu Lys Pro Ser Pro Leu 
145                 150                 155                 160 


Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln 
                165                 170                 175     


Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val 
            180                 185                 190         


His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly 
        195                 200                 205             


Gln Lys Glu Ile His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys 
    210                 215                 220                 


His Thr Lys Ile Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly 
225                 230                 235                 240 


Val Val Val Gln Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu 
                245                 250                 255     


Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala 
            260                 265                 270         


Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val 
        275                 280                 285             


Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val 
    290                 295                 300                 


Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp 
305                 310                 315                 320 


Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu 
                325                 330                 335     


His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu 
            340                 345                 350         


Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro 
        355                 360                 365             


Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro 
    370                 375                 380                 


Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe 
385                 390                 395                 400 


Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val 
                405                 410                 415     


Pro Val Thr Gly Ile Pro Pro His Val Val Lys Val Pro Ala Ser Gln 
            420                 425                 430         


Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro 
        435                 440                 445             


Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln 
    450                 455                 460                 


Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu 
465                 470                 475                 480 


Pro Arg Arg Met Val Arg His Pro Asp Ser His 
                485                 490     


<210>  16
<211>  653
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  16

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn 
        35                  40                  45              


Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys 
    50                  55                  60                  


Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu 
    130                 135                 140                 


Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln 
145                 150                 155                 160 


Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln 
                165                 170                 175     


Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala 
            180                 185                 190         


Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser 
        195                 200                 205             


Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro 
    210                 215                 220                 


Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln 
225                 230                 235                 240 


Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser 
                245                 250                 255     


Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro 
            260                 265                 270         


His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro 
        275                 280                 285             


Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg 
    290                 295                 300                 


Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg 
305                 310                 315                 320 


Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His 
                325                 330                 335     


Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp 
            340                 345                 350         


Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu 
        355                 360                 365             


Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val 
    370                 375                 380                 


Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile 
385                 390                 395                 400 


Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg 
                405                 410                 415     


Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly 
            420                 425                 430         


Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly 
        435                 440                 445             


Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro 
    450                 455                 460                 


Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly 
465                 470                 475                 480 


His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr 
                485                 490                 495     


Thr Tyr Glu Pro Glu Ala Met His Thr Leu Tyr Ala Pro Gly Gly Tyr 
            500                 505                 510         


Asp Ile Met Gly Trp Leu Ile Gln Ile Met Asn Arg Pro Asn Pro Gln 
        515                 520                 525             


Val Glu Leu Gly Pro Val Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp 
    530                 535                 540                 


Leu Lys Gln Lys Asp Thr Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu 
545                 550                 555                 560 


Tyr Met Thr Gly Tyr Ser Asn Ala Glu Val Leu Gly Arg Asn Cys Arg 
                565                 570                 575     


Phe Leu Gln Ser Pro Asp Gly Met Val Lys Pro Lys Ser Thr Arg Lys 
            580                 585                 590         


Tyr Val Asp Ser Asn Thr Ile Asn Thr Met Arg Lys Ala Ile Asp Arg 
        595                 600                 605             


Asn Ala Glu Val Gln Val Glu Val Val Asn Phe Lys Lys Asn Gly Gln 
    610                 615                 620                 


Arg Phe Val Asn Phe Leu Thr Met Ile Pro Val Arg Asp Glu Thr Gly 
625                 630                 635                 640 


Glu Tyr Arg Tyr Ser Met Gly Phe Gln Cys Glu Thr Glu 
                645                 650             


<210>  17
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17

Met Gly Phe Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu 
1               5                   10                  15      


Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser 
            20                  25                  30          


Gly Thr Phe Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His 
        35                  40                  45              


Leu Glu Glu Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro 
    50                  55                  60                  


Glu Gln Glu Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val 
65                  70                  75                  80  


Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala 
                85                  90                  95      


Pro Ala Asp Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser 
            100                 105                 110         


Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro 
        115                 120                 125             


Val Thr Gly Ile Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro 
    130                 135                 140                 


Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln 
145                 150                 155                 160 


Arg Asp Gln Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg 
                165                 170                 175     


Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro 
            180                 185                 190         


Arg Arg Met Val Arg His Pro Asp Ser His Gln Leu Phe Ile Gly Asn 
        195                 200                 205             


Leu Pro His Glu Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser 
    210                 215                 220                 


Tyr Gly Asn Val Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro 
225                 230                 235                 240 


Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val 
                245                 250                 255     


Leu Ser Asn Arg Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val 
            260                 265                 270         


Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn 
        275                 280                 285             


Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met 
    290                 295                 300                 


Arg Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val 
305                 310                 315                 320 


Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg 
                325                 330                 335     


Ala Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile 
            340                 345                 350         


Arg Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala Met His Thr Leu 
        355                 360                 365             


Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu Ile Gln Ile Met 
    370                 375                 380                 


Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val Asp Thr Ser Cys 
385                 390                 395                 400 


Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr Pro Ile Val Tyr 
                405                 410                 415     


Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser Asn Ala Glu Val 
            420                 425                 430         


Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp Gly Met Val Lys 
        435                 440                 445             


Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr Ile Asn Thr Met 
    450                 455                 460                 


Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val Glu Val Val Asn 
465                 470                 475                 480 


Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu Thr Met Ile Pro 
                485                 490                 495     


Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met Gly Phe Gln Cys 
            500                 505                 510         


Glu Thr Glu 
        515 


<210>  18
<211>  571
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  18

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn 
        35                  40                  45              


Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys 
    50                  55                  60                  


Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Thr Ala Pro Glu Asp 
    130                 135                 140                 


Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val 
145                 150                 155                 160 


Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn 
                165                 170                 175     


Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro His Val 
            180                 185                 190         


Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser 
        195                 200                 205             


Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln 
    210                 215                 220                 


Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala 
225                 230                 235                 240 


Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His Pro Asp 
                245                 250                 255     


Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser 
            260                 265                 270         


Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg 
        275                 280                 285             


Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp 
    290                 295                 300                 


Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe 
305                 310                 315                 320 


Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala 
                325                 330                 335     


Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro 
            340                 345                 350         


Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met 
        355                 360                 365             


Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln 
    370                 375                 380                 


Lys Leu Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly His Ser 
385                 390                 395                 400 


Cys Phe Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr 
                405                 410                 415     


Glu Pro Glu Ala Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile 
            420                 425                 430         


Met Gly Trp Leu Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu 
        435                 440                 445             


Leu Gly Pro Val Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys 
    450                 455                 460                 


Gln Lys Asp Thr Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met 
465                 470                 475                 480 


Thr Gly Tyr Ser Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu 
                485                 490                 495     


Gln Ser Pro Asp Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val 
            500                 505                 510         


Asp Ser Asn Thr Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala 
        515                 520                 525             


Glu Val Gln Val Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe 
    530                 535                 540                 


Val Asn Phe Leu Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr 
545                 550                 555                 560 


Arg Tyr Ser Met Gly Phe Gln Cys Glu Thr Glu 
                565                 570     


<210>  19
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  19

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn 
        35                  40                  45              


Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys 
    50                  55                  60                  


Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu 
    130                 135                 140                 


Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln 
145                 150                 155                 160 


Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln 
                165                 170                 175     


Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala 
            180                 185                 190         


Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser 
        195                 200                 205             


Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Gln Leu Phe 
    210                 215                 220                 


Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu Lys Asp Phe 
225                 230                 235                 240 


Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn Ser Gly Gly 
                245                 250                 255     


Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro Val 
            260                 265                 270         


Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly Glu Val Arg 
        275                 280                 285             


Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg 
    290                 295                 300                 


Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly 
305                 310                 315                 320 


Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly 
                325                 330                 335     


Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met 
            340                 345                 350         


Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu 
        355                 360                 365             


Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala Met 
    370                 375                 380                 


His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu Ile 
385                 390                 395                 400 


Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val Asp 
                405                 410                 415     


Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr Pro 
            420                 425                 430         


Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser Asn 
        435                 440                 445             


Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp Gly 
    450                 455                 460                 


Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr Ile 
465                 470                 475                 480 


Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val Glu 
                485                 490                 495     


Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu Thr 
            500                 505                 510         


Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met Gly 
        515                 520                 525             


Phe Gln Cys Glu Thr Glu 
    530                 


<210>  20
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  20

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn 
        35                  40                  45              


Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys 
    50                  55                  60                  


Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu 
    130                 135                 140                 


Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln 
145                 150                 155                 160 


Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln 
                165                 170                 175     


Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala 
            180                 185                 190         


Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser 
        195                 200                 205             


Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro 
    210                 215                 220                 


Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln 
225                 230                 235                 240 


Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser 
                245                 250                 255     


Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro 
            260                 265                 270         


His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro 
        275                 280                 285             


Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg 
    290                 295                 300                 


Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg 
305                 310                 315                 320 


Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His 
                325                 330                 335     


Pro Asp Ser His Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg 
            340                 345                 350         


Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly 
        355                 360                 365             


Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly 
    370                 375                 380                 


Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met 
385                 390                 395                 400 


Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu 
                405                 410                 415     


Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala Met 
            420                 425                 430         


His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu Ile 
        435                 440                 445             


Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val Asp 
    450                 455                 460                 


Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr Pro 
465                 470                 475                 480 


Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser Asn 
                485                 490                 495     


Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp Gly 
            500                 505                 510         


Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr Ile 
        515                 520                 525             


Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val Glu 
    530                 535                 540                 


Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu Thr 
545                 550                 555                 560 


Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met Gly 
                565                 570                 575     


Phe Gln Cys Glu Thr Glu 
            580         


<210>  21
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  21

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn 
        35                  40                  45              


Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys 
    50                  55                  60                  


Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu 
    130                 135                 140                 


Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln 
145                 150                 155                 160 


Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln 
                165                 170                 175     


Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala 
            180                 185                 190         


Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser 
        195                 200                 205             


Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro 
    210                 215                 220                 


Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln 
225                 230                 235                 240 


Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser 
                245                 250                 255     


Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro 
            260                 265                 270         


His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro 
        275                 280                 285             


Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg 
    290                 295                 300                 


Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg 
305                 310                 315                 320 


Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His 
                325                 330                 335     


Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp 
            340                 345                 350         


Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu 
        355                 360                 365             


Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val 
    370                 375                 380                 


Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile 
385                 390                 395                 400 


Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Met His Thr Leu Tyr 
                405                 410                 415     


Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu Ile Gln Ile Met Asn 
            420                 425                 430         


Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val Asp Thr Ser Cys Ala 
        435                 440                 445             


Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr Pro Ile Val Tyr Ala 
    450                 455                 460                 


Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser Asn Ala Glu Val Leu 
465                 470                 475                 480 


Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp Gly Met Val Lys Pro 
                485                 490                 495     


Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr Ile Asn Thr Met Arg 
            500                 505                 510         


Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val Glu Val Val Asn Phe 
        515                 520                 525             


Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu Thr Met Ile Pro Val 
    530                 535                 540                 


Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met Gly Phe Gln Cys Glu 
545                 550                 555                 560 


Thr Glu 
        


<210>  22
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  22

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn 
        35                  40                  45              


Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys 
    50                  55                  60                  


Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu 
    130                 135                 140                 


Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln 
145                 150                 155                 160 


Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln 
                165                 170                 175     


Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala 
            180                 185                 190         


Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser 
        195                 200                 205             


Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro 
    210                 215                 220                 


Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln 
225                 230                 235                 240 


Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser 
                245                 250                 255     


Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro 
            260                 265                 270         


His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro 
        275                 280                 285             


Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg 
    290                 295                 300                 


Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg 
305                 310                 315                 320 


Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His 
                325                 330                 335     


Pro Asp Ser His Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile 
            340                 345                 350         


Met Gly Trp Leu Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu 
        355                 360                 365             


Leu Gly Pro Val Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys 
    370                 375                 380                 


Gln Lys Asp Thr Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met 
385                 390                 395                 400 


Thr Gly Tyr Ser Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu 
                405                 410                 415     


Gln Ser Pro Asp Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val 
            420                 425                 430         


Asp Ser Asn Thr Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala 
        435                 440                 445             


Glu Val Gln Val Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe 
    450                 455                 460                 


Val Asn Phe Leu Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr 
465                 470                 475                 480 


Arg Tyr Ser Met Gly Phe Gln Cys Glu Thr Glu 
                485                 490     


<210>  23
<211>  665
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  23

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg 
                165                 170                 175     


Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met 
            180                 185                 190         


Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu 
        195                 200                 205             


Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile 
    210                 215                 220                 


His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile 
225                 230                 235                 240 


Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln 
                245                 250                 255     


Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met 
            260                 265                 270         


Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr 
        275                 280                 285             


Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe 
    290                 295                 300                 


Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu 
305                 310                 315                 320 


Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe 
                325                 330                 335     


Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu 
            340                 345                 350         


Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu 
        355                 360                 365             


Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu 
    370                 375                 380                 


Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp 
385                 390                 395                 400 


Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser 
                405                 410                 415     


Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly 
            420                 425                 430         


Ile Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu 
        435                 440                 445             


Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln 
    450                 455                 460                 


Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg 
465                 470                 475                 480 


Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met 
                485                 490                 495     


Val Arg His Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His 
            500                 505                 510         


Glu Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn 
        515                 520                 525             


Val Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly 
    530                 535                 540                 


Phe Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn 
545                 550                 555                 560 


Arg Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys 
                565                 570                 575     


Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg 
            580                 585                 590         


Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro 
        595                 600                 605             


Pro Arg Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly 
    610                 615                 620                 


Leu Ala Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala Trp Leu 
625                 630                 635                 640 


Glu His Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg Ser Gln 
                645                 650                 655     


Phe His Thr Thr Tyr Glu Pro Glu Ala 
            660                 665 


<210>  24
<211>  527
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  24

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Gly Phe Val Thr Glu Pro Gln Glu Glu Ser Glu Glu 
                165                 170                 175     


Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu Val Val Pro 
            180                 185                 190         


Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser Asn Asp Met 
        195                 200                 205             


Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro Asp Pro Glu 
    210                 215                 220                 


Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu Glu Lys Pro 
225                 230                 235                 240 


Glu Pro Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser 
                245                 250                 255     


Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu Asp Leu Arg 
            260                 265                 270         


Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro Ser Gly 
        275                 280                 285             


Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys Val Pro Ala 
    290                 295                 300                 


Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln 
305                 310                 315                 320 


Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile Asn Ile Pro 
                325                 330                 335     


Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp 
            340                 345                 350         


Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His Gln Leu Phe 
        355                 360                 365             


Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu Lys Asp Phe 
    370                 375                 380                 


Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn Ser Gly Gly 
385                 390                 395                 400 


Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro Val 
                405                 410                 415     


Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly Glu Val Arg 
            420                 425                 430         


Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg 
        435                 440                 445             


Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly 
    450                 455                 460                 


Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly 
465                 470                 475                 480 


Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met 
                485                 490                 495     


Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu 
            500                 505                 510         


Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala 
        515                 520                 525         


<210>  25
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  25

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg 
                165                 170                 175     


Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met 
            180                 185                 190         


Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu 
        195                 200                 205             


Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile 
    210                 215                 220                 


His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile 
225                 230                 235                 240 


Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln 
                245                 250                 255     


Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met 
            260                 265                 270         


Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr 
        275                 280                 285             


Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Thr Ala 
    290                 295                 300                 


Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala 
305                 310                 315                 320 


Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr 
                325                 330                 335     


Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro 
            340                 345                 350         


Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys 
        355                 360                 365             


Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val 
    370                 375                 380                 


Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile 
385                 390                 395                 400 


Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg 
                405                 410                 415     


His Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val 
            420                 425                 430         


Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val 
        435                 440                 445             


Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val 
    450                 455                 460                 


Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro 
465                 470                 475                 480 


Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr 
                485                 490                 495     


Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro 
            500                 505                 510         


Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg 
        515                 520                 525             


Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala 
    530                 535                 540                 


Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His 
545                 550                 555                 560 


Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His 
                565                 570                 575     


Thr Thr Tyr Glu Pro Glu Ala 
            580             


<210>  26
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  26

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg 
                165                 170                 175     


Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met 
            180                 185                 190         


Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu 
        195                 200                 205             


Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile 
    210                 215                 220                 


His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile 
225                 230                 235                 240 


Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln 
                245                 250                 255     


Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met 
            260                 265                 270         


Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr 
        275                 280                 285             


Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe 
    290                 295                 300                 


Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu 
305                 310                 315                 320 


Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe 
                325                 330                 335     


Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu 
            340                 345                 350         


Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu 
        355                 360                 365             


Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu 
    370                 375                 380                 


Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu 
385                 390                 395                 400 


Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn 
                405                 410                 415     


Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser 
            420                 425                 430         


Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly 
        435                 440                 445             


Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu 
    450                 455                 460                 


Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly 
465                 470                 475                 480 


Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln 
                485                 490                 495     


Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu 
            500                 505                 510         


Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe 
        515                 520                 525             


Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro 
    530                 535                 540                 


Glu Ala 
545     


<210>  27
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  27

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg 
                165                 170                 175     


Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met 
            180                 185                 190         


Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu 
        195                 200                 205             


Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile 
    210                 215                 220                 


His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile 
225                 230                 235                 240 


Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln 
                245                 250                 255     


Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met 
            260                 265                 270         


Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr 
        275                 280                 285             


Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe 
    290                 295                 300                 


Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu 
305                 310                 315                 320 


Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe 
                325                 330                 335     


Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu 
            340                 345                 350         


Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu 
        355                 360                 365             


Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu 
    370                 375                 380                 


Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp 
385                 390                 395                 400 


Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser 
                405                 410                 415     


Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly 
            420                 425                 430         


Ile Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu 
        435                 440                 445             


Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln 
    450                 455                 460                 


Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg 
465                 470                 475                 480 


Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met 
                485                 490                 495     


Val Arg His Pro Asp Ser His Glu Lys Lys Thr Arg Ala Ala Arg Glu 
            500                 505                 510         


Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly 
        515                 520                 525             


Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln 
    530                 535                 540                 


Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu 
545                 550                 555                 560 


Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe 
                565                 570                 575     


Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro 
            580                 585                 590         


Glu Ala 
        


<210>  28
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  28

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg 
                165                 170                 175     


Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met 
            180                 185                 190         


Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu 
        195                 200                 205             


Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile 
    210                 215                 220                 


His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile 
225                 230                 235                 240 


Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln 
                245                 250                 255     


Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met 
            260                 265                 270         


Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr 
        275                 280                 285             


Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe 
    290                 295                 300                 


Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu 
305                 310                 315                 320 


Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe 
                325                 330                 335     


Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu 
            340                 345                 350         


Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu 
        355                 360                 365             


Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu 
    370                 375                 380                 


Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp 
385                 390                 395                 400 


Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser 
                405                 410                 415     


Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly 
            420                 425                 430         


Ile Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu 
        435                 440                 445             


Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln 
    450                 455                 460                 


Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg 
465                 470                 475                 480 


Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met 
                485                 490                 495     


Val Arg His Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His 
            500                 505                 510         


Glu Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn 
        515                 520                 525             


Val Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly 
    530                 535                 540                 


Phe Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn 
545                 550                 555                 560 


Arg Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu 
                565                 570                 


<210>  29
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  29

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg 
                165                 170                 175     


Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met 
            180                 185                 190         


Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu 
        195                 200                 205             


Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile 
    210                 215                 220                 


His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile 
225                 230                 235                 240 


Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln 
                245                 250                 255     


Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met 
            260                 265                 270         


Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr 
        275                 280                 285             


Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe 
    290                 295                 300                 


Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu 
305                 310                 315                 320 


Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe 
                325                 330                 335     


Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu 
            340                 345                 350         


Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu 
        355                 360                 365             


Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu 
    370                 375                 380                 


Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp 
385                 390                 395                 400 


Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser 
                405                 410                 415     


Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly 
            420                 425                 430         


Ile Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu 
        435                 440                 445             


Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln 
    450                 455                 460                 


Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg 
465                 470                 475                 480 


Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met 
                485                 490                 495     


Val Arg His Pro Asp Ser His 
            500             


<210>  30
<211>  665
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  30

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg 
                165                 170                 175     


Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met 
            180                 185                 190         


Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu 
        195                 200                 205             


Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile 
    210                 215                 220                 


His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile 
225                 230                 235                 240 


Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln 
                245                 250                 255     


Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met 
            260                 265                 270         


Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr 
        275                 280                 285             


Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe 
    290                 295                 300                 


Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu 
305                 310                 315                 320 


Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe 
                325                 330                 335     


Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu 
            340                 345                 350         


Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu 
        355                 360                 365             


Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu 
    370                 375                 380                 


Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp 
385                 390                 395                 400 


Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser 
                405                 410                 415     


Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly 
            420                 425                 430         


Ile Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu 
        435                 440                 445             


Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln 
    450                 455                 460                 


Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg 
465                 470                 475                 480 


Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met 
                485                 490                 495     


Val Arg His Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His 
            500                 505                 510         


Glu Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn 
        515                 520                 525             


Val Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly 
    530                 535                 540                 


Phe Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn 
545                 550                 555                 560 


Arg Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys 
                565                 570                 575     


Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg 
            580                 585                 590         


Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro 
        595                 600                 605             


Pro Arg Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly 
    610                 615                 620                 


Leu Ala Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala Trp Leu 
625                 630                 635                 640 


Glu His Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg Ser Gln 
                645                 650                 655     


Phe His Thr Thr Tyr Glu Pro Glu Ala 
            660                 665 


<210>  31
<211>  527
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  31

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Gly Phe Val Thr Glu Pro Gln Glu Glu Ser Glu Glu 
                165                 170                 175     


Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu Val Val Pro 
            180                 185                 190         


Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser Asn Asp Met 
        195                 200                 205             


Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro Asp Pro Glu 
    210                 215                 220                 


Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu Glu Lys Pro 
225                 230                 235                 240 


Glu Pro Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser 
                245                 250                 255     


Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu Asp Leu Arg 
            260                 265                 270         


Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro Ser Gly 
        275                 280                 285             


Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys Val Pro Ala 
    290                 295                 300                 


Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln 
305                 310                 315                 320 


Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile Asn Ile Pro 
                325                 330                 335     


Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp 
            340                 345                 350         


Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His Gln Leu Phe 
        355                 360                 365             


Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu Lys Asp Phe 
    370                 375                 380                 


Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn Ser Gly Gly 
385                 390                 395                 400 


Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro Val 
                405                 410                 415     


Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly Glu Val Arg 
            420                 425                 430         


Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg 
        435                 440                 445             


Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly 
    450                 455                 460                 


Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly 
465                 470                 475                 480 


Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met 
                485                 490                 495     


Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu 
            500                 505                 510         


Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala 
        515                 520                 525         


<210>  32
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  32

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg 
                165                 170                 175     


Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met 
            180                 185                 190         


Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu 
        195                 200                 205             


Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile 
    210                 215                 220                 


His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile 
225                 230                 235                 240 


Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln 
                245                 250                 255     


Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met 
            260                 265                 270         


Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr 
        275                 280                 285             


Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Thr Ala 
    290                 295                 300                 


Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala 
305                 310                 315                 320 


Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr 
                325                 330                 335     


Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro 
            340                 345                 350         


Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys 
        355                 360                 365             


Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val 
    370                 375                 380                 


Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile 
385                 390                 395                 400 


Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg 
                405                 410                 415     


His Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val 
            420                 425                 430         


Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val 
        435                 440                 445             


Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val 
    450                 455                 460                 


Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro 
465                 470                 475                 480 


Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr 
                485                 490                 495     


Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro 
            500                 505                 510         


Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg 
        515                 520                 525             


Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala 
    530                 535                 540                 


Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His 
545                 550                 555                 560 


Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His 
                565                 570                 575     


Thr Thr Tyr Glu Pro Glu Ala 
            580             


<210>  33
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  33

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg 
                165                 170                 175     


Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met 
            180                 185                 190         


Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu 
        195                 200                 205             


Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile 
    210                 215                 220                 


His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile 
225                 230                 235                 240 


Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln 
                245                 250                 255     


Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met 
            260                 265                 270         


Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr 
        275                 280                 285             


Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe 
    290                 295                 300                 


Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu 
305                 310                 315                 320 


Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe 
                325                 330                 335     


Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu 
            340                 345                 350         


Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu 
        355                 360                 365             


Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu 
    370                 375                 380                 


Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu 
385                 390                 395                 400 


Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn 
                405                 410                 415     


Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser 
            420                 425                 430         


Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly 
        435                 440                 445             


Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu 
    450                 455                 460                 


Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly 
465                 470                 475                 480 


Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln 
                485                 490                 495     


Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu 
            500                 505                 510         


Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe 
        515                 520                 525             


Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro 
    530                 535                 540                 


Glu Ala 
545     


<210>  34
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  34

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg 
                165                 170                 175     


Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met 
            180                 185                 190         


Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu 
        195                 200                 205             


Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile 
    210                 215                 220                 


His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile 
225                 230                 235                 240 


Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln 
                245                 250                 255     


Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met 
            260                 265                 270         


Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr 
        275                 280                 285             


Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe 
    290                 295                 300                 


Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu 
305                 310                 315                 320 


Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe 
                325                 330                 335     


Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu 
            340                 345                 350         


Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu 
        355                 360                 365             


Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu 
    370                 375                 380                 


Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp 
385                 390                 395                 400 


Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser 
                405                 410                 415     


Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly 
            420                 425                 430         


Ile Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu 
        435                 440                 445             


Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln 
    450                 455                 460                 


Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg 
465                 470                 475                 480 


Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met 
                485                 490                 495     


Val Arg His Pro Asp Ser His Glu Lys Lys Thr Arg Ala Ala Arg Glu 
            500                 505                 510         


Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly 
        515                 520                 525             


Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln 
    530                 535                 540                 


Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu 
545                 550                 555                 560 


Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe 
                565                 570                 575     


Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro 
            580                 585                 590         


Glu Ala 
        


<210>  35
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  35

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg 
                165                 170                 175     


Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met 
            180                 185                 190         


Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu 
        195                 200                 205             


Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile 
    210                 215                 220                 


His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile 
225                 230                 235                 240 


Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln 
                245                 250                 255     


Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met 
            260                 265                 270         


Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr 
        275                 280                 285             


Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe 
    290                 295                 300                 


Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu 
305                 310                 315                 320 


Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe 
                325                 330                 335     


Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu 
            340                 345                 350         


Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu 
        355                 360                 365             


Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu 
    370                 375                 380                 


Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp 
385                 390                 395                 400 


Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser 
                405                 410                 415     


Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly 
            420                 425                 430         


Ile Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu 
        435                 440                 445             


Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln 
    450                 455                 460                 


Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg 
465                 470                 475                 480 


Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met 
                485                 490                 495     


Val Arg His Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His 
            500                 505                 510         


Glu Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn 
        515                 520                 525             


Val Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly 
    530                 535                 540                 


Phe Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn 
545                 550                 555                 560 


Arg Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu 
                565                 570                 


<210>  36
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  36

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg 
                165                 170                 175     


Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met 
            180                 185                 190         


Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu 
        195                 200                 205             


Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile 
    210                 215                 220                 


His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile 
225                 230                 235                 240 


Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln 
                245                 250                 255     


Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met 
            260                 265                 270         


Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr 
        275                 280                 285             


Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe 
    290                 295                 300                 


Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu 
305                 310                 315                 320 


Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe 
                325                 330                 335     


Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu 
            340                 345                 350         


Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu 
        355                 360                 365             


Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu 
    370                 375                 380                 


Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp 
385                 390                 395                 400 


Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser 
                405                 410                 415     


Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly 
            420                 425                 430         


Ile Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu 
        435                 440                 445             


Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln 
    450                 455                 460                 


Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg 
465                 470                 475                 480 


Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met 
                485                 490                 495     


Val Arg His Pro Asp Ser His 
            500             


<210>  37
<211>  665
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  37

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg 
                165                 170                 175     


Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met 
            180                 185                 190         


Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu 
        195                 200                 205             


Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile 
    210                 215                 220                 


His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile 
225                 230                 235                 240 


Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln 
                245                 250                 255     


Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met 
            260                 265                 270         


Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr 
        275                 280                 285             


Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe 
    290                 295                 300                 


Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu 
305                 310                 315                 320 


Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe 
                325                 330                 335     


Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu 
            340                 345                 350         


Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu 
        355                 360                 365             


Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu 
    370                 375                 380                 


Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp 
385                 390                 395                 400 


Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser 
                405                 410                 415     


Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly 
            420                 425                 430         


Ile Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu 
        435                 440                 445             


Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln 
    450                 455                 460                 


Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg 
465                 470                 475                 480 


Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met 
                485                 490                 495     


Val Arg His Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His 
            500                 505                 510         


Glu Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn 
        515                 520                 525             


Val Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly 
    530                 535                 540                 


Phe Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn 
545                 550                 555                 560 


Arg Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys 
                565                 570                 575     


Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg 
            580                 585                 590         


Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro 
        595                 600                 605             


Pro Arg Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly 
    610                 615                 620                 


Leu Ala Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala Trp Leu 
625                 630                 635                 640 


Glu His Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg Ser Gln 
                645                 650                 655     


Phe His Thr Thr Tyr Glu Pro Glu Ala 
            660                 665 


<210>  38
<211>  527
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  38

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Gly Phe Val Thr Glu Pro Gln Glu Glu Ser Glu Glu 
                165                 170                 175     


Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu Val Val Pro 
            180                 185                 190         


Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser Asn Asp Met 
        195                 200                 205             


Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro Asp Pro Glu 
    210                 215                 220                 


Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu Glu Lys Pro 
225                 230                 235                 240 


Glu Pro Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser 
                245                 250                 255     


Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu Asp Leu Arg 
            260                 265                 270         


Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro Ser Gly 
        275                 280                 285             


Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys Val Pro Ala 
    290                 295                 300                 


Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln 
305                 310                 315                 320 


Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile Asn Ile Pro 
                325                 330                 335     


Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp 
            340                 345                 350         


Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His Gln Leu Phe 
        355                 360                 365             


Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu Lys Asp Phe 
    370                 375                 380                 


Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn Ser Gly Gly 
385                 390                 395                 400 


Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro Val 
                405                 410                 415     


Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly Glu Val Arg 
            420                 425                 430         


Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg 
        435                 440                 445             


Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly 
    450                 455                 460                 


Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly 
465                 470                 475                 480 


Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met 
                485                 490                 495     


Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu 
            500                 505                 510         


Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala 
        515                 520                 525         


<210>  39
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  39

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg 
                165                 170                 175     


Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met 
            180                 185                 190         


Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu 
        195                 200                 205             


Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile 
    210                 215                 220                 


His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile 
225                 230                 235                 240 


Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln 
                245                 250                 255     


Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met 
            260                 265                 270         


Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr 
        275                 280                 285             


Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Thr Ala 
    290                 295                 300                 


Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala 
305                 310                 315                 320 


Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr 
                325                 330                 335     


Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro 
            340                 345                 350         


Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys 
        355                 360                 365             


Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val 
    370                 375                 380                 


Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile 
385                 390                 395                 400 


Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg 
                405                 410                 415     


His Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val 
            420                 425                 430         


Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val 
        435                 440                 445             


Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val 
    450                 455                 460                 


Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro 
465                 470                 475                 480 


Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr 
                485                 490                 495     


Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro 
            500                 505                 510         


Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg 
        515                 520                 525             


Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala 
    530                 535                 540                 


Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His 
545                 550                 555                 560 


Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His 
                565                 570                 575     


Thr Thr Tyr Glu Pro Glu Ala 
            580             


<210>  40
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  40

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg 
                165                 170                 175     


Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met 
            180                 185                 190         


Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu 
        195                 200                 205             


Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile 
    210                 215                 220                 


His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile 
225                 230                 235                 240 


Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln 
                245                 250                 255     


Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met 
            260                 265                 270         


Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr 
        275                 280                 285             


Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe 
    290                 295                 300                 


Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu 
305                 310                 315                 320 


Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe 
                325                 330                 335     


Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu 
            340                 345                 350         


Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu 
        355                 360                 365             


Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu 
    370                 375                 380                 


Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu 
385                 390                 395                 400 


Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn 
                405                 410                 415     


Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser 
            420                 425                 430         


Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly 
        435                 440                 445             


Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu 
    450                 455                 460                 


Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly 
465                 470                 475                 480 


Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln 
                485                 490                 495     


Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu 
            500                 505                 510         


Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe 
        515                 520                 525             


Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro 
    530                 535                 540                 


Glu Ala 
545     


<210>  41
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  41

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg 
                165                 170                 175     


Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met 
            180                 185                 190         


Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu 
        195                 200                 205             


Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile 
    210                 215                 220                 


His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile 
225                 230                 235                 240 


Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln 
                245                 250                 255     


Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met 
            260                 265                 270         


Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr 
        275                 280                 285             


Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe 
    290                 295                 300                 


Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu 
305                 310                 315                 320 


Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe 
                325                 330                 335     


Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu 
            340                 345                 350         


Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu 
        355                 360                 365             


Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu 
    370                 375                 380                 


Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp 
385                 390                 395                 400 


Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser 
                405                 410                 415     


Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly 
            420                 425                 430         


Ile Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu 
        435                 440                 445             


Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln 
    450                 455                 460                 


Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg 
465                 470                 475                 480 


Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met 
                485                 490                 495     


Val Arg His Pro Asp Ser His Glu Lys Lys Thr Arg Ala Ala Arg Glu 
            500                 505                 510         


Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly 
        515                 520                 525             


Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln 
    530                 535                 540                 


Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu 
545                 550                 555                 560 


Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe 
                565                 570                 575     


Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro 
            580                 585                 590         


Glu Ala 
        


<210>  42
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  42

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg 
                165                 170                 175     


Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met 
            180                 185                 190         


Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu 
        195                 200                 205             


Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile 
    210                 215                 220                 


His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile 
225                 230                 235                 240 


Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln 
                245                 250                 255     


Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met 
            260                 265                 270         


Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr 
        275                 280                 285             


Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe 
    290                 295                 300                 


Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu 
305                 310                 315                 320 


Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe 
                325                 330                 335     


Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu 
            340                 345                 350         


Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu 
        355                 360                 365             


Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu 
    370                 375                 380                 


Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp 
385                 390                 395                 400 


Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser 
                405                 410                 415     


Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly 
            420                 425                 430         


Ile Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu 
        435                 440                 445             


Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln 
    450                 455                 460                 


Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg 
465                 470                 475                 480 


Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met 
                485                 490                 495     


Val Arg His Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His 
            500                 505                 510         


Glu Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn 
        515                 520                 525             


Val Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly 
    530                 535                 540                 


Phe Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn 
545                 550                 555                 560 


Arg Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu 
                565                 570                 


<210>  43
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  43

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg 
                165                 170                 175     


Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met 
            180                 185                 190         


Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu 
        195                 200                 205             


Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile 
    210                 215                 220                 


His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile 
225                 230                 235                 240 


Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln 
                245                 250                 255     


Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met 
            260                 265                 270         


Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr 
        275                 280                 285             


Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe 
    290                 295                 300                 


Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu 
305                 310                 315                 320 


Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe 
                325                 330                 335     


Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu 
            340                 345                 350         


Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu 
        355                 360                 365             


Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu 
    370                 375                 380                 


Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp 
385                 390                 395                 400 


Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser 
                405                 410                 415     


Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly 
            420                 425                 430         


Ile Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu 
        435                 440                 445             


Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln 
    450                 455                 460                 


Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg 
465                 470                 475                 480 


Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met 
                485                 490                 495     


Val Arg His Pro Asp Ser His 
            500             


<210>  44
<211>  665
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  44

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg 
                165                 170                 175     


Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met 
            180                 185                 190         


Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu 
        195                 200                 205             


Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile 
    210                 215                 220                 


His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile 
225                 230                 235                 240 


Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln 
                245                 250                 255     


Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met 
            260                 265                 270         


Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr 
        275                 280                 285             


Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe 
    290                 295                 300                 


Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu 
305                 310                 315                 320 


Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe 
                325                 330                 335     


Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu 
            340                 345                 350         


Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu 
        355                 360                 365             


Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu 
    370                 375                 380                 


Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp 
385                 390                 395                 400 


Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser 
                405                 410                 415     


Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly 
            420                 425                 430         


Ile Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu 
        435                 440                 445             


Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln 
    450                 455                 460                 


Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg 
465                 470                 475                 480 


Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met 
                485                 490                 495     


Val Arg His Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His 
            500                 505                 510         


Glu Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn 
        515                 520                 525             


Val Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly 
    530                 535                 540                 


Phe Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn 
545                 550                 555                 560 


Arg Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys 
                565                 570                 575     


Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg 
            580                 585                 590         


Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro 
        595                 600                 605             


Pro Arg Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly 
    610                 615                 620                 


Leu Ala Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala Trp Leu 
625                 630                 635                 640 


Glu His Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg Ser Gln 
                645                 650                 655     


Phe His Thr Thr Tyr Glu Pro Glu Ala 
            660                 665 


<210>  45
<211>  527
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  45

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Gly Phe Val Thr Glu Pro Gln Glu Glu Ser Glu Glu 
                165                 170                 175     


Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu Val Val Pro 
            180                 185                 190         


Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser Asn Asp Met 
        195                 200                 205             


Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro Asp Pro Glu 
    210                 215                 220                 


Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu Glu Lys Pro 
225                 230                 235                 240 


Glu Pro Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser 
                245                 250                 255     


Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu Asp Leu Arg 
            260                 265                 270         


Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro Ser Gly 
        275                 280                 285             


Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys Val Pro Ala 
    290                 295                 300                 


Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln 
305                 310                 315                 320 


Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile Asn Ile Pro 
                325                 330                 335     


Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp 
            340                 345                 350         


Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His Gln Leu Phe 
        355                 360                 365             


Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu Lys Asp Phe 
    370                 375                 380                 


Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn Ser Gly Gly 
385                 390                 395                 400 


Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro Val 
                405                 410                 415     


Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly Glu Val Arg 
            420                 425                 430         


Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg 
        435                 440                 445             


Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly 
    450                 455                 460                 


Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly 
465                 470                 475                 480 


Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met 
                485                 490                 495     


Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu 
            500                 505                 510         


Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala 
        515                 520                 525         


<210>  46
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  46

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg 
                165                 170                 175     


Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met 
            180                 185                 190         


Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu 
        195                 200                 205             


Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile 
    210                 215                 220                 


His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile 
225                 230                 235                 240 


Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln 
                245                 250                 255     


Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met 
            260                 265                 270         


Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr 
        275                 280                 285             


Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Thr Ala 
    290                 295                 300                 


Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala 
305                 310                 315                 320 


Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr 
                325                 330                 335     


Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro 
            340                 345                 350         


Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys 
        355                 360                 365             


Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val 
    370                 375                 380                 


Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile 
385                 390                 395                 400 


Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg 
                405                 410                 415     


His Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val 
            420                 425                 430         


Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val 
        435                 440                 445             


Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val 
    450                 455                 460                 


Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro 
465                 470                 475                 480 


Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr 
                485                 490                 495     


Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro 
            500                 505                 510         


Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg 
        515                 520                 525             


Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala 
    530                 535                 540                 


Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His 
545                 550                 555                 560 


Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His 
                565                 570                 575     


Thr Thr Tyr Glu Pro Glu Ala 
            580             


<210>  47
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  47

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg 
                165                 170                 175     


Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met 
            180                 185                 190         


Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu 
        195                 200                 205             


Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile 
    210                 215                 220                 


His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile 
225                 230                 235                 240 


Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln 
                245                 250                 255     


Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met 
            260                 265                 270         


Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr 
        275                 280                 285             


Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe 
    290                 295                 300                 


Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu 
305                 310                 315                 320 


Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe 
                325                 330                 335     


Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu 
            340                 345                 350         


Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu 
        355                 360                 365             


Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu 
    370                 375                 380                 


Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu 
385                 390                 395                 400 


Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn 
                405                 410                 415     


Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser 
            420                 425                 430         


Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly 
        435                 440                 445             


Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu 
    450                 455                 460                 


Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly 
465                 470                 475                 480 


Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln 
                485                 490                 495     


Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu 
            500                 505                 510         


Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe 
        515                 520                 525             


Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro 
    530                 535                 540                 


Glu Ala 
545     


<210>  48
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  48

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg 
                165                 170                 175     


Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met 
            180                 185                 190         


Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu 
        195                 200                 205             


Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile 
    210                 215                 220                 


His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile 
225                 230                 235                 240 


Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln 
                245                 250                 255     


Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met 
            260                 265                 270         


Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr 
        275                 280                 285             


Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe 
    290                 295                 300                 


Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu 
305                 310                 315                 320 


Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe 
                325                 330                 335     


Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu 
            340                 345                 350         


Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu 
        355                 360                 365             


Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu 
    370                 375                 380                 


Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp 
385                 390                 395                 400 


Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser 
                405                 410                 415     


Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly 
            420                 425                 430         


Ile Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu 
        435                 440                 445             


Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln 
    450                 455                 460                 


Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg 
465                 470                 475                 480 


Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met 
                485                 490                 495     


Val Arg His Pro Asp Ser His Glu Lys Lys Thr Arg Ala Ala Arg Glu 
            500                 505                 510         


Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly 
        515                 520                 525             


Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln 
    530                 535                 540                 


Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu 
545                 550                 555                 560 


Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe 
                565                 570                 575     


Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro 
            580                 585                 590         


Glu Ala 
        


<210>  49
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  49

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg 
                165                 170                 175     


Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met 
            180                 185                 190         


Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu 
        195                 200                 205             


Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile 
    210                 215                 220                 


His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile 
225                 230                 235                 240 


Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln 
                245                 250                 255     


Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met 
            260                 265                 270         


Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr 
        275                 280                 285             


Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe 
    290                 295                 300                 


Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu 
305                 310                 315                 320 


Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe 
                325                 330                 335     


Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu 
            340                 345                 350         


Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu 
        355                 360                 365             


Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu 
    370                 375                 380                 


Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp 
385                 390                 395                 400 


Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser 
                405                 410                 415     


Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly 
            420                 425                 430         


Ile Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu 
        435                 440                 445             


Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln 
    450                 455                 460                 


Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg 
465                 470                 475                 480 


Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met 
                485                 490                 495     


Val Arg His Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His 
            500                 505                 510         


Glu Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn 
        515                 520                 525             


Val Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly 
    530                 535                 540                 


Phe Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn 
545                 550                 555                 560 


Arg Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu 
                565                 570                 


<210>  50
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  50

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg 
                165                 170                 175     


Glu Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met 
            180                 185                 190         


Leu His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu 
        195                 200                 205             


Asp Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile 
    210                 215                 220                 


His Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile 
225                 230                 235                 240 


Arg His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln 
                245                 250                 255     


Val Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met 
            260                 265                 270         


Gln Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr 
        275                 280                 285             


Val His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe 
    290                 295                 300                 


Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu 
305                 310                 315                 320 


Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe 
                325                 330                 335     


Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu 
            340                 345                 350         


Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu 
        355                 360                 365             


Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu 
    370                 375                 380                 


Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp 
385                 390                 395                 400 


Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser 
                405                 410                 415     


Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly 
            420                 425                 430         


Ile Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu 
        435                 440                 445             


Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln 
    450                 455                 460                 


Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg 
465                 470                 475                 480 


Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met 
                485                 490                 495     


Val Arg His Pro Asp Ser His 
            500             


<210>  51
<211>  674
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  51

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Val Met Glu 
                165                 170                 175     


Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr 
            180                 185                 190         


Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys 
        195                 200                 205             


Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala 
    210                 215                 220                 


Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys Val Met Ser Gln 
225                 230                 235                 240 


Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val Asp Ala His Ala 
                245                 250                 255     


Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly Leu Leu Ser Asn 
            260                 265                 270         


Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro 
        275                 280                 285             


Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg 
    290                 295                 300                 


Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu 
305                 310                 315                 320 


Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu 
                325                 330                 335     


Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser 
            340                 345                 350         


Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro 
        355                 360                 365             


Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu 
    370                 375                 380                 


Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln 
385                 390                 395                 400 


Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu 
                405                 410                 415     


Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro 
            420                 425                 430         


Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys 
        435                 440                 445             


Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile 
    450                 455                 460                 


Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile 
465                 470                 475                 480 


Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu 
                485                 490                 495     


Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His 
            500                 505                 510         


Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu 
        515                 520                 525             


Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn 
    530                 535                 540                 


Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser 
545                 550                 555                 560 


Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly 
                565                 570                 575     


Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu 
            580                 585                 590         


Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly 
        595                 600                 605             


Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln 
    610                 615                 620                 


Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu 
625                 630                 635                 640 


Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe 
                645                 650                 655     


Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro 
            660                 665                 670         


Glu Ala 
        


<210>  52
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  52

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Gly Phe Val 
                165                 170                 175     


Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu 
            180                 185                 190         


Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr 
        195                 200                 205             


Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro 
    210                 215                 220                 


Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro 
225                 230                 235                 240 


Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr 
                245                 250                 255     


Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile 
            260                 265                 270         


Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val 
        275                 280                 285             


Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile 
    290                 295                 300                 


Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser 
305                 310                 315                 320 


Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg 
                325                 330                 335     


Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro 
            340                 345                 350         


Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val 
        355                 360                 365             


Arg His Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu 
    370                 375                 380                 


Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val 
385                 390                 395                 400 


Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe 
                405                 410                 415     


Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg 
            420                 425                 430         


Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys 
        435                 440                 445             


Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly 
    450                 455                 460                 


Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro 
465                 470                 475                 480 


Arg Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu 
                485                 490                 495     


Ala Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala Trp Leu Glu 
            500                 505                 510         


His Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg Ser Gln Phe 
        515                 520                 525             


His Thr Thr Tyr Glu Pro Glu Ala 
    530                 535     


<210>  53
<211>  592
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  53

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Val Met Glu 
                165                 170                 175     


Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr 
            180                 185                 190         


Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys 
        195                 200                 205             


Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala 
    210                 215                 220                 


Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys Val Met Ser Gln 
225                 230                 235                 240 


Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val Asp Ala His Ala 
                245                 250                 255     


Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly Leu Leu Ser Asn 
            260                 265                 270         


Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro 
        275                 280                 285             


Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg 
    290                 295                 300                 


Tyr Gln Asp Glu Val Phe Gly Thr Ala Pro Glu Asp Ala Gln Lys Ser 
305                 310                 315                 320 


Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu Asp Leu 
                325                 330                 335     


Arg Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro Ser 
            340                 345                 350         


Gly Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys Val Pro 
        355                 360                 365             


Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile Pro Pro 
    370                 375                 380                 


Gln Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile Asn Ile 
385                 390                 395                 400 


Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu Gln Gly 
                405                 410                 415     


Asp Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His Gln Leu 
            420                 425                 430         


Phe Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu Lys Asp 
        435                 440                 445             


Phe Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn Ser Gly 
    450                 455                 460                 


Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro 
465                 470                 475                 480 


Val Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly Glu Val 
                485                 490                 495     


Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp 
            500                 505                 510         


Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu 
        515                 520                 525             


Gly Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro 
    530                 535                 540                 


Gly Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro 
545                 550                 555                 560 


Met Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe Leu Cys 
                565                 570                 575     


Glu Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala 
            580                 585                 590         


<210>  54
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  54

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Val Met Glu 
                165                 170                 175     


Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr 
            180                 185                 190         


Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys 
        195                 200                 205             


Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala 
    210                 215                 220                 


Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys Val Met Ser Gln 
225                 230                 235                 240 


Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val Asp Ala His Ala 
                245                 250                 255     


Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly Leu Leu Ser Asn 
            260                 265                 270         


Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro 
        275                 280                 285             


Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg 
    290                 295                 300                 


Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu 
305                 310                 315                 320 


Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu 
                325                 330                 335     


Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser 
            340                 345                 350         


Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro 
        355                 360                 365             


Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu 
    370                 375                 380                 


Glu Lys Pro Glu Pro Val Leu Glu Glu Gln Leu Phe Ile Gly Asn Leu 
385                 390                 395                 400 


Pro His Glu Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr 
                405                 410                 415     


Gly Asn Val Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn 
            420                 425                 430         


Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu 
        435                 440                 445             


Ser Asn Arg Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu 
    450                 455                 460                 


Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg 
465                 470                 475                 480 


Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg 
                485                 490                 495     


Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly 
            500                 505                 510         


Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala 
        515                 520                 525             


Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg 
    530                 535                 540                 


Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala 
545                 550                 555 


<210>  55
<211>  603
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  55

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Val Met Glu 
                165                 170                 175     


Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr 
            180                 185                 190         


Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys 
        195                 200                 205             


Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala 
    210                 215                 220                 


Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys Val Met Ser Gln 
225                 230                 235                 240 


Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val Asp Ala His Ala 
                245                 250                 255     


Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly Leu Leu Ser Asn 
            260                 265                 270         


Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro 
        275                 280                 285             


Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg 
    290                 295                 300                 


Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu 
305                 310                 315                 320 


Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu 
                325                 330                 335     


Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser 
            340                 345                 350         


Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro 
        355                 360                 365             


Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu 
    370                 375                 380                 


Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln 
385                 390                 395                 400 


Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu 
                405                 410                 415     


Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro 
            420                 425                 430         


Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys 
        435                 440                 445             


Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile 
    450                 455                 460                 


Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile 
465                 470                 475                 480 


Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu 
                485                 490                 495     


Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His 
            500                 505                 510         


Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg 
        515                 520                 525             


Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg 
    530                 535                 540                 


Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly 
545                 550                 555                 560 


Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala 
                565                 570                 575     


Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg 
            580                 585                 590         


Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala 
        595                 600             


<210>  56
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  56

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Val Met Glu 
                165                 170                 175     


Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr 
            180                 185                 190         


Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys 
        195                 200                 205             


Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala 
    210                 215                 220                 


Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys Val Met Ser Gln 
225                 230                 235                 240 


Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val Asp Ala His Ala 
                245                 250                 255     


Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly Leu Leu Ser Asn 
            260                 265                 270         


Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro 
        275                 280                 285             


Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg 
    290                 295                 300                 


Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu 
305                 310                 315                 320 


Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu 
                325                 330                 335     


Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser 
            340                 345                 350         


Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro 
        355                 360                 365             


Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu 
    370                 375                 380                 


Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln 
385                 390                 395                 400 


Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu 
                405                 410                 415     


Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro 
            420                 425                 430         


Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys 
        435                 440                 445             


Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile 
    450                 455                 460                 


Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile 
465                 470                 475                 480 


Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu 
                485                 490                 495     


Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His 
            500                 505                 510         


Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu 
        515                 520                 525             


Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn 
    530                 535                 540                 


Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser 
545                 550                 555                 560 


Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly 
                565                 570                 575     


Glu Val Arg Leu Asn Val Glu 
            580             


<210>  57
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  57

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Val Met Glu 
                165                 170                 175     


Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr 
            180                 185                 190         


Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys 
        195                 200                 205             


Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala 
    210                 215                 220                 


Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys Val Met Ser Gln 
225                 230                 235                 240 


Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val Asp Ala His Ala 
                245                 250                 255     


Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly Leu Leu Ser Asn 
            260                 265                 270         


Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro 
        275                 280                 285             


Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg 
    290                 295                 300                 


Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu 
305                 310                 315                 320 


Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu 
                325                 330                 335     


Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser 
            340                 345                 350         


Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro 
        355                 360                 365             


Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu 
    370                 375                 380                 


Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln 
385                 390                 395                 400 


Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu 
                405                 410                 415     


Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro 
            420                 425                 430         


Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys 
        435                 440                 445             


Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile 
    450                 455                 460                 


Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile 
465                 470                 475                 480 


Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu 
                485                 490                 495     


Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His 
            500                 505                 510         


<210>  58
<211>  674
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  58

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Val Met Glu 
                165                 170                 175     


Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr 
            180                 185                 190         


Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys 
        195                 200                 205             


Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala 
    210                 215                 220                 


Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys Val Met Ser Gln 
225                 230                 235                 240 


Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val Asp Ala His Ala 
                245                 250                 255     


Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly Leu Leu Ser Asn 
            260                 265                 270         


Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro 
        275                 280                 285             


Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg 
    290                 295                 300                 


Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu 
305                 310                 315                 320 


Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu 
                325                 330                 335     


Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser 
            340                 345                 350         


Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro 
        355                 360                 365             


Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu 
    370                 375                 380                 


Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln 
385                 390                 395                 400 


Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu 
                405                 410                 415     


Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro 
            420                 425                 430         


Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys 
        435                 440                 445             


Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile 
    450                 455                 460                 


Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile 
465                 470                 475                 480 


Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu 
                485                 490                 495     


Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His 
            500                 505                 510         


Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu 
        515                 520                 525             


Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn 
    530                 535                 540                 


Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser 
545                 550                 555                 560 


Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly 
                565                 570                 575     


Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu 
            580                 585                 590         


Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly 
        595                 600                 605             


Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln 
    610                 615                 620                 


Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu 
625                 630                 635                 640 


Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe 
                645                 650                 655     


Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro 
            660                 665                 670         


Glu Ala 
        


<210>  59
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  59

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Gly Phe Val 
                165                 170                 175     


Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu 
            180                 185                 190         


Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr 
        195                 200                 205             


Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro 
    210                 215                 220                 


Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro 
225                 230                 235                 240 


Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr 
                245                 250                 255     


Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile 
            260                 265                 270         


Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val 
        275                 280                 285             


Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile 
    290                 295                 300                 


Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser 
305                 310                 315                 320 


Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg 
                325                 330                 335     


Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro 
            340                 345                 350         


Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val 
        355                 360                 365             


Arg His Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu 
    370                 375                 380                 


Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val 
385                 390                 395                 400 


Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe 
                405                 410                 415     


Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg 
            420                 425                 430         


Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys 
        435                 440                 445             


Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly 
    450                 455                 460                 


Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro 
465                 470                 475                 480 


Arg Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu 
                485                 490                 495     


Ala Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala Trp Leu Glu 
            500                 505                 510         


His Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg Ser Gln Phe 
        515                 520                 525             


His Thr Thr Tyr Glu Pro Glu Ala 
    530                 535     


<210>  60
<211>  592
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  60

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Val Met Glu 
                165                 170                 175     


Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr 
            180                 185                 190         


Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys 
        195                 200                 205             


Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala 
    210                 215                 220                 


Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys Val Met Ser Gln 
225                 230                 235                 240 


Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val Asp Ala His Ala 
                245                 250                 255     


Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly Leu Leu Ser Asn 
            260                 265                 270         


Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro 
        275                 280                 285             


Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg 
    290                 295                 300                 


Tyr Gln Asp Glu Val Phe Gly Thr Ala Pro Glu Asp Ala Gln Lys Ser 
305                 310                 315                 320 


Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu Asp Leu 
                325                 330                 335     


Arg Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro Ser 
            340                 345                 350         


Gly Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys Val Pro 
        355                 360                 365             


Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile Pro Pro 
    370                 375                 380                 


Gln Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile Asn Ile 
385                 390                 395                 400 


Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu Gln Gly 
                405                 410                 415     


Asp Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His Gln Leu 
            420                 425                 430         


Phe Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu Lys Asp 
        435                 440                 445             


Phe Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn Ser Gly 
    450                 455                 460                 


Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro 
465                 470                 475                 480 


Val Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly Glu Val 
                485                 490                 495     


Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp 
            500                 505                 510         


Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu 
        515                 520                 525             


Gly Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro 
    530                 535                 540                 


Gly Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro 
545                 550                 555                 560 


Met Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe Leu Cys 
                565                 570                 575     


Glu Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala 
            580                 585                 590         


<210>  61
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  61

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Val Met Glu 
                165                 170                 175     


Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr 
            180                 185                 190         


Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys 
        195                 200                 205             


Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala 
    210                 215                 220                 


Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys Val Met Ser Gln 
225                 230                 235                 240 


Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val Asp Ala His Ala 
                245                 250                 255     


Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly Leu Leu Ser Asn 
            260                 265                 270         


Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro 
        275                 280                 285             


Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg 
    290                 295                 300                 


Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu 
305                 310                 315                 320 


Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu 
                325                 330                 335     


Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser 
            340                 345                 350         


Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro 
        355                 360                 365             


Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu 
    370                 375                 380                 


Glu Lys Pro Glu Pro Val Leu Glu Glu Gln Leu Phe Ile Gly Asn Leu 
385                 390                 395                 400 


Pro His Glu Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr 
                405                 410                 415     


Gly Asn Val Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn 
            420                 425                 430         


Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu 
        435                 440                 445             


Ser Asn Arg Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu 
    450                 455                 460                 


Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg 
465                 470                 475                 480 


Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg 
                485                 490                 495     


Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly 
            500                 505                 510         


Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala 
        515                 520                 525             


Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg 
    530                 535                 540                 


Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala 
545                 550                 555 


<210>  62
<211>  603
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  62

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Val Met Glu 
                165                 170                 175     


Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr 
            180                 185                 190         


Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys 
        195                 200                 205             


Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala 
    210                 215                 220                 


Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys Val Met Ser Gln 
225                 230                 235                 240 


Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val Asp Ala His Ala 
                245                 250                 255     


Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly Leu Leu Ser Asn 
            260                 265                 270         


Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro 
        275                 280                 285             


Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg 
    290                 295                 300                 


Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu 
305                 310                 315                 320 


Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu 
                325                 330                 335     


Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser 
            340                 345                 350         


Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro 
        355                 360                 365             


Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu 
    370                 375                 380                 


Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln 
385                 390                 395                 400 


Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu 
                405                 410                 415     


Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro 
            420                 425                 430         


Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys 
        435                 440                 445             


Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile 
    450                 455                 460                 


Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile 
465                 470                 475                 480 


Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu 
                485                 490                 495     


Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His 
            500                 505                 510         


Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg 
        515                 520                 525             


Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg 
    530                 535                 540                 


Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly 
545                 550                 555                 560 


Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala 
                565                 570                 575     


Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg 
            580                 585                 590         


Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala 
        595                 600             


<210>  63
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  63

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Val Met Glu 
                165                 170                 175     


Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr 
            180                 185                 190         


Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys 
        195                 200                 205             


Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala 
    210                 215                 220                 


Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys Val Met Ser Gln 
225                 230                 235                 240 


Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val Asp Ala His Ala 
                245                 250                 255     


Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly Leu Leu Ser Asn 
            260                 265                 270         


Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro 
        275                 280                 285             


Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg 
    290                 295                 300                 


Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu 
305                 310                 315                 320 


Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu 
                325                 330                 335     


Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser 
            340                 345                 350         


Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro 
        355                 360                 365             


Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu 
    370                 375                 380                 


Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln 
385                 390                 395                 400 


Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu 
                405                 410                 415     


Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro 
            420                 425                 430         


Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys 
        435                 440                 445             


Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile 
    450                 455                 460                 


Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile 
465                 470                 475                 480 


Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu 
                485                 490                 495     


Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His 
            500                 505                 510         


Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu 
        515                 520                 525             


Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn 
    530                 535                 540                 


Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser 
545                 550                 555                 560 


Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly 
                565                 570                 575     


Glu Val Arg Leu Asn Val Glu 
            580             


<210>  64
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  64

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Val Met Glu 
                165                 170                 175     


Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr 
            180                 185                 190         


Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys 
        195                 200                 205             


Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala 
    210                 215                 220                 


Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys Val Met Ser Gln 
225                 230                 235                 240 


Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val Asp Ala His Ala 
                245                 250                 255     


Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly Leu Leu Ser Asn 
            260                 265                 270         


Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro 
        275                 280                 285             


Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg 
    290                 295                 300                 


Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu 
305                 310                 315                 320 


Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu 
                325                 330                 335     


Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser 
            340                 345                 350         


Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro 
        355                 360                 365             


Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu 
    370                 375                 380                 


Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln 
385                 390                 395                 400 


Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu 
                405                 410                 415     


Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro 
            420                 425                 430         


Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys 
        435                 440                 445             


Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile 
    450                 455                 460                 


Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile 
465                 470                 475                 480 


Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu 
                485                 490                 495     


Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His 
            500                 505                 510         


<210>  65
<211>  674
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  65

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Val Met Glu 
                165                 170                 175     


Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr 
            180                 185                 190         


Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys 
        195                 200                 205             


Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala 
    210                 215                 220                 


Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys Val Met Ser Gln 
225                 230                 235                 240 


Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val Asp Ala His Ala 
                245                 250                 255     


Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly Leu Leu Ser Asn 
            260                 265                 270         


Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro 
        275                 280                 285             


Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg 
    290                 295                 300                 


Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu 
305                 310                 315                 320 


Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu 
                325                 330                 335     


Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser 
            340                 345                 350         


Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro 
        355                 360                 365             


Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu 
    370                 375                 380                 


Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln 
385                 390                 395                 400 


Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu 
                405                 410                 415     


Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro 
            420                 425                 430         


Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys 
        435                 440                 445             


Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile 
    450                 455                 460                 


Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile 
465                 470                 475                 480 


Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu 
                485                 490                 495     


Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His 
            500                 505                 510         


Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu 
        515                 520                 525             


Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn 
    530                 535                 540                 


Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser 
545                 550                 555                 560 


Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly 
                565                 570                 575     


Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu 
            580                 585                 590         


Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly 
        595                 600                 605             


Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln 
    610                 615                 620                 


Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu 
625                 630                 635                 640 


Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe 
                645                 650                 655     


Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro 
            660                 665                 670         


Glu Ala 
        


<210>  66
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  66

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Gly Phe Val 
                165                 170                 175     


Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu 
            180                 185                 190         


Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr 
        195                 200                 205             


Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro 
    210                 215                 220                 


Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro 
225                 230                 235                 240 


Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr 
                245                 250                 255     


Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile 
            260                 265                 270         


Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val 
        275                 280                 285             


Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile 
    290                 295                 300                 


Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser 
305                 310                 315                 320 


Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg 
                325                 330                 335     


Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro 
            340                 345                 350         


Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val 
        355                 360                 365             


Arg His Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu 
    370                 375                 380                 


Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val 
385                 390                 395                 400 


Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe 
                405                 410                 415     


Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg 
            420                 425                 430         


Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys 
        435                 440                 445             


Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly 
    450                 455                 460                 


Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro 
465                 470                 475                 480 


Arg Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu 
                485                 490                 495     


Ala Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala Trp Leu Glu 
            500                 505                 510         


His Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg Ser Gln Phe 
        515                 520                 525             


His Thr Thr Tyr Glu Pro Glu Ala 
    530                 535     


<210>  67
<211>  592
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  67

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Val Met Glu 
                165                 170                 175     


Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr 
            180                 185                 190         


Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys 
        195                 200                 205             


Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala 
    210                 215                 220                 


Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys Val Met Ser Gln 
225                 230                 235                 240 


Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val Asp Ala His Ala 
                245                 250                 255     


Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly Leu Leu Ser Asn 
            260                 265                 270         


Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro 
        275                 280                 285             


Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg 
    290                 295                 300                 


Tyr Gln Asp Glu Val Phe Gly Thr Ala Pro Glu Asp Ala Gln Lys Ser 
305                 310                 315                 320 


Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu Asp Leu 
                325                 330                 335     


Arg Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro Ser 
            340                 345                 350         


Gly Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys Val Pro 
        355                 360                 365             


Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile Pro Pro 
    370                 375                 380                 


Gln Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile Asn Ile 
385                 390                 395                 400 


Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu Gln Gly 
                405                 410                 415     


Asp Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His Gln Leu 
            420                 425                 430         


Phe Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu Lys Asp 
        435                 440                 445             


Phe Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn Ser Gly 
    450                 455                 460                 


Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro 
465                 470                 475                 480 


Val Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly Glu Val 
                485                 490                 495     


Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp 
            500                 505                 510         


Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu 
        515                 520                 525             


Gly Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro 
    530                 535                 540                 


Gly Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro 
545                 550                 555                 560 


Met Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe Leu Cys 
                565                 570                 575     


Glu Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala 
            580                 585                 590         


<210>  68
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  68

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Val Met Glu 
                165                 170                 175     


Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr 
            180                 185                 190         


Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys 
        195                 200                 205             


Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala 
    210                 215                 220                 


Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys Val Met Ser Gln 
225                 230                 235                 240 


Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val Asp Ala His Ala 
                245                 250                 255     


Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly Leu Leu Ser Asn 
            260                 265                 270         


Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro 
        275                 280                 285             


Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg 
    290                 295                 300                 


Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu 
305                 310                 315                 320 


Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu 
                325                 330                 335     


Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser 
            340                 345                 350         


Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro 
        355                 360                 365             


Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu 
    370                 375                 380                 


Glu Lys Pro Glu Pro Val Leu Glu Glu Gln Leu Phe Ile Gly Asn Leu 
385                 390                 395                 400 


Pro His Glu Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr 
                405                 410                 415     


Gly Asn Val Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn 
            420                 425                 430         


Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu 
        435                 440                 445             


Ser Asn Arg Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu 
    450                 455                 460                 


Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg 
465                 470                 475                 480 


Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg 
                485                 490                 495     


Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly 
            500                 505                 510         


Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala 
        515                 520                 525             


Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg 
    530                 535                 540                 


Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala 
545                 550                 555 


<210>  69
<211>  603
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  69

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Val Met Glu 
                165                 170                 175     


Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr 
            180                 185                 190         


Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys 
        195                 200                 205             


Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala 
    210                 215                 220                 


Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys Val Met Ser Gln 
225                 230                 235                 240 


Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val Asp Ala His Ala 
                245                 250                 255     


Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly Leu Leu Ser Asn 
            260                 265                 270         


Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro 
        275                 280                 285             


Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg 
    290                 295                 300                 


Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu 
305                 310                 315                 320 


Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu 
                325                 330                 335     


Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser 
            340                 345                 350         


Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro 
        355                 360                 365             


Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu 
    370                 375                 380                 


Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln 
385                 390                 395                 400 


Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu 
                405                 410                 415     


Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro 
            420                 425                 430         


Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys 
        435                 440                 445             


Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile 
    450                 455                 460                 


Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile 
465                 470                 475                 480 


Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu 
                485                 490                 495     


Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His 
            500                 505                 510         


Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg 
        515                 520                 525             


Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg 
    530                 535                 540                 


Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly 
545                 550                 555                 560 


Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala 
                565                 570                 575     


Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg 
            580                 585                 590         


Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala 
        595                 600             


<210>  70
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  70

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Val Met Glu 
                165                 170                 175     


Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr 
            180                 185                 190         


Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys 
        195                 200                 205             


Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala 
    210                 215                 220                 


Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys Val Met Ser Gln 
225                 230                 235                 240 


Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val Asp Ala His Ala 
                245                 250                 255     


Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly Leu Leu Ser Asn 
            260                 265                 270         


Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro 
        275                 280                 285             


Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg 
    290                 295                 300                 


Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu 
305                 310                 315                 320 


Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu 
                325                 330                 335     


Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser 
            340                 345                 350         


Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro 
        355                 360                 365             


Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu 
    370                 375                 380                 


Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln 
385                 390                 395                 400 


Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu 
                405                 410                 415     


Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro 
            420                 425                 430         


Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys 
        435                 440                 445             


Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile 
    450                 455                 460                 


Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile 
465                 470                 475                 480 


Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu 
                485                 490                 495     


Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His 
            500                 505                 510         


Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu 
        515                 520                 525             


Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn 
    530                 535                 540                 


Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser 
545                 550                 555                 560 


Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly 
                565                 570                 575     


Glu Val Arg Leu Asn Val Glu 
            580             


<210>  71
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  71

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Val Met Glu 
                165                 170                 175     


Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr 
            180                 185                 190         


Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys 
        195                 200                 205             


Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala 
    210                 215                 220                 


Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys Val Met Ser Gln 
225                 230                 235                 240 


Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val Asp Ala His Ala 
                245                 250                 255     


Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly Leu Leu Ser Asn 
            260                 265                 270         


Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro 
        275                 280                 285             


Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg 
    290                 295                 300                 


Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu 
305                 310                 315                 320 


Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu 
                325                 330                 335     


Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser 
            340                 345                 350         


Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro 
        355                 360                 365             


Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu 
    370                 375                 380                 


Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln 
385                 390                 395                 400 


Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu 
                405                 410                 415     


Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro 
            420                 425                 430         


Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys 
        435                 440                 445             


Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile 
    450                 455                 460                 


Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile 
465                 470                 475                 480 


Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu 
                485                 490                 495     


Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His 
            500                 505                 510         


<210>  72
<211>  674
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  72

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Val Met Glu 
                165                 170                 175     


Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr 
            180                 185                 190         


Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys 
        195                 200                 205             


Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala 
    210                 215                 220                 


Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys Val Met Ser Gln 
225                 230                 235                 240 


Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val Asp Ala His Ala 
                245                 250                 255     


Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly Leu Leu Ser Asn 
            260                 265                 270         


Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro 
        275                 280                 285             


Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg 
    290                 295                 300                 


Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu 
305                 310                 315                 320 


Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu 
                325                 330                 335     


Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser 
            340                 345                 350         


Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro 
        355                 360                 365             


Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu 
    370                 375                 380                 


Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln 
385                 390                 395                 400 


Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu 
                405                 410                 415     


Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro 
            420                 425                 430         


Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys 
        435                 440                 445             


Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile 
    450                 455                 460                 


Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile 
465                 470                 475                 480 


Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu 
                485                 490                 495     


Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His 
            500                 505                 510         


Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu 
        515                 520                 525             


Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn 
    530                 535                 540                 


Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser 
545                 550                 555                 560 


Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly 
                565                 570                 575     


Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu 
            580                 585                 590         


Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly 
        595                 600                 605             


Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln 
    610                 615                 620                 


Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu 
625                 630                 635                 640 


Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe 
                645                 650                 655     


Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro 
            660                 665                 670         


Glu Ala 
        


<210>  73
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  73

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Gly Phe Val 
                165                 170                 175     


Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu 
            180                 185                 190         


Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr 
        195                 200                 205             


Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro 
    210                 215                 220                 


Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro 
225                 230                 235                 240 


Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr 
                245                 250                 255     


Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile 
            260                 265                 270         


Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val 
        275                 280                 285             


Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile 
    290                 295                 300                 


Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser 
305                 310                 315                 320 


Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg 
                325                 330                 335     


Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro 
            340                 345                 350         


Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val 
        355                 360                 365             


Arg His Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu 
    370                 375                 380                 


Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val 
385                 390                 395                 400 


Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe 
                405                 410                 415     


Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg 
            420                 425                 430         


Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys 
        435                 440                 445             


Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly 
    450                 455                 460                 


Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro 
465                 470                 475                 480 


Arg Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu 
                485                 490                 495     


Ala Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala Trp Leu Glu 
            500                 505                 510         


His Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg Ser Gln Phe 
        515                 520                 525             


His Thr Thr Tyr Glu Pro Glu Ala 
    530                 535     


<210>  74
<211>  592
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  74

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Val Met Glu 
                165                 170                 175     


Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr 
            180                 185                 190         


Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys 
        195                 200                 205             


Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala 
    210                 215                 220                 


Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys Val Met Ser Gln 
225                 230                 235                 240 


Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val Asp Ala His Ala 
                245                 250                 255     


Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly Leu Leu Ser Asn 
            260                 265                 270         


Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro 
        275                 280                 285             


Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg 
    290                 295                 300                 


Tyr Gln Asp Glu Val Phe Gly Thr Ala Pro Glu Asp Ala Gln Lys Ser 
305                 310                 315                 320 


Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu Asp Leu 
                325                 330                 335     


Arg Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro Ser 
            340                 345                 350         


Gly Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys Val Pro 
        355                 360                 365             


Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile Pro Pro 
    370                 375                 380                 


Gln Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile Asn Ile 
385                 390                 395                 400 


Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu Gln Gly 
                405                 410                 415     


Asp Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His Gln Leu 
            420                 425                 430         


Phe Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu Lys Asp 
        435                 440                 445             


Phe Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn Ser Gly 
    450                 455                 460                 


Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro 
465                 470                 475                 480 


Val Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly Glu Val 
                485                 490                 495     


Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp 
            500                 505                 510         


Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu 
        515                 520                 525             


Gly Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro 
    530                 535                 540                 


Gly Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro 
545                 550                 555                 560 


Met Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe Leu Cys 
                565                 570                 575     


Glu Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala 
            580                 585                 590         


<210>  75
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  75

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Val Met Glu 
                165                 170                 175     


Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr 
            180                 185                 190         


Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys 
        195                 200                 205             


Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala 
    210                 215                 220                 


Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys Val Met Ser Gln 
225                 230                 235                 240 


Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val Asp Ala His Ala 
                245                 250                 255     


Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly Leu Leu Ser Asn 
            260                 265                 270         


Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro 
        275                 280                 285             


Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg 
    290                 295                 300                 


Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu 
305                 310                 315                 320 


Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu 
                325                 330                 335     


Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser 
            340                 345                 350         


Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro 
        355                 360                 365             


Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu 
    370                 375                 380                 


Glu Lys Pro Glu Pro Val Leu Glu Glu Gln Leu Phe Ile Gly Asn Leu 
385                 390                 395                 400 


Pro His Glu Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr 
                405                 410                 415     


Gly Asn Val Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn 
            420                 425                 430         


Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu 
        435                 440                 445             


Ser Asn Arg Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu 
    450                 455                 460                 


Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg 
465                 470                 475                 480 


Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg 
                485                 490                 495     


Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly 
            500                 505                 510         


Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala 
        515                 520                 525             


Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg 
    530                 535                 540                 


Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala 
545                 550                 555 


<210>  76
<211>  603
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  76

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Val Met Glu 
                165                 170                 175     


Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr 
            180                 185                 190         


Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys 
        195                 200                 205             


Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala 
    210                 215                 220                 


Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys Val Met Ser Gln 
225                 230                 235                 240 


Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val Asp Ala His Ala 
                245                 250                 255     


Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly Leu Leu Ser Asn 
            260                 265                 270         


Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro 
        275                 280                 285             


Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg 
    290                 295                 300                 


Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu 
305                 310                 315                 320 


Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu 
                325                 330                 335     


Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser 
            340                 345                 350         


Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro 
        355                 360                 365             


Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu 
    370                 375                 380                 


Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln 
385                 390                 395                 400 


Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu 
                405                 410                 415     


Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro 
            420                 425                 430         


Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys 
        435                 440                 445             


Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile 
    450                 455                 460                 


Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile 
465                 470                 475                 480 


Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu 
                485                 490                 495     


Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His 
            500                 505                 510         


Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg 
        515                 520                 525             


Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg 
    530                 535                 540                 


Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly 
545                 550                 555                 560 


Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala 
                565                 570                 575     


Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg 
            580                 585                 590         


Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala 
        595                 600             


<210>  77
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  77

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Val Met Glu 
                165                 170                 175     


Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr 
            180                 185                 190         


Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys 
        195                 200                 205             


Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala 
    210                 215                 220                 


Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys Val Met Ser Gln 
225                 230                 235                 240 


Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val Asp Ala His Ala 
                245                 250                 255     


Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly Leu Leu Ser Asn 
            260                 265                 270         


Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro 
        275                 280                 285             


Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg 
    290                 295                 300                 


Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu 
305                 310                 315                 320 


Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu 
                325                 330                 335     


Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser 
            340                 345                 350         


Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro 
        355                 360                 365             


Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu 
    370                 375                 380                 


Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln 
385                 390                 395                 400 


Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu 
                405                 410                 415     


Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro 
            420                 425                 430         


Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys 
        435                 440                 445             


Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile 
    450                 455                 460                 


Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile 
465                 470                 475                 480 


Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu 
                485                 490                 495     


Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His 
            500                 505                 510         


Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu 
        515                 520                 525             


Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn 
    530                 535                 540                 


Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser 
545                 550                 555                 560 


Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly 
                565                 570                 575     


Glu Val Arg Leu Asn Val Glu 
            580             


<210>  78
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  78

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Cys Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Val Ala Leu Val Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Val Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Ser Gly Met Val Met Glu 
                165                 170                 175     


Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val Arg Gln Tyr Tyr 
            180                 185                 190         


Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg Phe Tyr Gly Lys 
        195                 200                 205             


Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn Gly Lys Pro Ala 
    210                 215                 220                 


Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys Val Met Ser Gln 
225                 230                 235                 240 


Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val Asp Ala His Ala 
                245                 250                 255     


Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly Leu Leu Ser Asn 
            260                 265                 270         


Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe Val Leu Ala Pro 
        275                 280                 285             


Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn Asp Ile Phe Arg 
    290                 295                 300                 


Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu Pro Gln Glu Glu 
305                 310                 315                 320 


Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu 
                325                 330                 335     


Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser 
            340                 345                 350         


Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro 
        355                 360                 365             


Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu 
    370                 375                 380                 


Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln 
385                 390                 395                 400 


Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu 
                405                 410                 415     


Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro 
            420                 425                 430         


Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys 
        435                 440                 445             


Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile 
    450                 455                 460                 


Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile 
465                 470                 475                 480 


Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu 
                485                 490                 495     


Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His 
            500                 505                 510         


<210>  79
<211>  1000
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  79

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu 
            500                 505                 510         


Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu 
        515                 520                 525             


His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp 
    530                 535                 540                 


Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His 
545                 550                 555                 560 


Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg 
                565                 570                 575     


His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val 
            580                 585                 590         


Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln 
        595                 600                 605             


Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val 
    610                 615                 620                 


His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val 
625                 630                 635                 640 


Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu 
                645                 650                 655     


Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr 
            660                 665                 670         


Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro 
        675                 680                 685             


Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro 
    690                 695                 700                 


Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr 
705                 710                 715                 720 


Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile 
                725                 730                 735     


Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val 
            740                 745                 750         


Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile 
        755                 760                 765             


Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser 
    770                 775                 780                 


Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg 
785                 790                 795                 800 


Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro 
                805                 810                 815     


Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val 
            820                 825                 830         


Arg His Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu 
        835                 840                 845             


Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val 
    850                 855                 860                 


Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe 
865                 870                 875                 880 


Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg 
                885                 890                 895     


Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys 
            900                 905                 910         


Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly 
        915                 920                 925             


Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro 
    930                 935                 940                 


Arg Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu 
945                 950                 955                 960 


Ala Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala Trp Leu Glu 
                965                 970                 975     


His Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg Ser Gln Phe 
            980                 985                 990         


His Thr Thr Tyr Glu Pro Glu Ala  
        995                 1000 


<210>  80
<211>  862
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  80

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Met Gly Phe Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu 
            500                 505                 510         


Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp 
        515                 520                 525             


Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu 
    530                 535                 540                 


Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro 
545                 550                 555                 560 


Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu 
                565                 570                 575     


Pro Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser 
            580                 585                 590         


Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr 
        595                 600                 605             


Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala 
    610                 615                 620                 


Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys Val Pro Ala Ser 
625                 630                 635                 640 


Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg 
                645                 650                 655     


Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro 
            660                 665                 670         


Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile 
        675                 680                 685             


Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His Gln Leu Phe Ile 
    690                 695                 700                 


Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu Lys Asp Phe Phe 
705                 710                 715                 720 


Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn Ser Gly Gly Lys 
                725                 730                 735     


Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro Val Gln 
            740                 745                 750         


Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly Glu Val Arg Leu 
        755                 760                 765             


Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg 
    770                 775                 780                 


Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly 
785                 790                 795                 800 


Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly Phe 
                805                 810                 815     


Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met Ala 
            820                 825                 830         


Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu Ile 
        835                 840                 845             


Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala 
    850                 855                 860         


<210>  81
<211>  918
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  81

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu 
            500                 505                 510         


Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu 
        515                 520                 525             


His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp 
    530                 535                 540                 


Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His 
545                 550                 555                 560 


Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg 
                565                 570                 575     


His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val 
            580                 585                 590         


Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln 
        595                 600                 605             


Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val 
    610                 615                 620                 


His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Thr Ala Pro 
625                 630                 635                 640 


Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln 
                645                 650                 655     


Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser 
            660                 665                 670         


Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro 
        675                 680                 685             


His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro 
    690                 695                 700                 


Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg 
705                 710                 715                 720 


Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg 
                725                 730                 735     


Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His 
            740                 745                 750         


Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp 
        755                 760                 765             


Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu 
    770                 775                 780                 


Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val 
785                 790                 795                 800 


Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile 
                805                 810                 815     


Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg 
            820                 825                 830         


Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly 
        835                 840                 845             


Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly 
    850                 855                 860                 


Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro 
865                 870                 875                 880 


Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly 
                885                 890                 895     


His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr 
            900                 905                 910         


Thr Tyr Glu Pro Glu Ala 
        915             


<210>  82
<211>  881
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  82

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu 
            500                 505                 510         


Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu 
        515                 520                 525             


His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp 
    530                 535                 540                 


Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His 
545                 550                 555                 560 


Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg 
                565                 570                 575     


His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val 
            580                 585                 590         


Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln 
        595                 600                 605             


Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val 
    610                 615                 620                 


His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val 
625                 630                 635                 640 


Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu 
                645                 650                 655     


Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr 
            660                 665                 670         


Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro 
        675                 680                 685             


Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro 
    690                 695                 700                 


Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Gln 
705                 710                 715                 720 


Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu Lys 
                725                 730                 735     


Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn Ser 
            740                 745                 750         


Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu 
        755                 760                 765             


Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly Glu 
    770                 775                 780                 


Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly 
785                 790                 795                 800 


Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly 
                805                 810                 815     


Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln Lys 
            820                 825                 830         


Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile 
        835                 840                 845             


Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe Leu 
    850                 855                 860                 


Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro Glu 
865                 870                 875                 880 


Ala 
    


<210>  83
<211>  929
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  83

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu 
            500                 505                 510         


Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu 
        515                 520                 525             


His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp 
    530                 535                 540                 


Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His 
545                 550                 555                 560 


Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg 
                565                 570                 575     


His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val 
            580                 585                 590         


Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln 
        595                 600                 605             


Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val 
    610                 615                 620                 


His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val 
625                 630                 635                 640 


Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu 
                645                 650                 655     


Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr 
            660                 665                 670         


Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro 
        675                 680                 685             


Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro 
    690                 695                 700                 


Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr 
705                 710                 715                 720 


Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile 
                725                 730                 735     


Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val 
            740                 745                 750         


Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile 
        755                 760                 765             


Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser 
    770                 775                 780                 


Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg 
785                 790                 795                 800 


Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro 
                805                 810                 815     


Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val 
            820                 825                 830         


Arg His Pro Asp Ser His Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly 
        835                 840                 845             


Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly 
    850                 855                 860                 


Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln Lys 
865                 870                 875                 880 


Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile 
                885                 890                 895     


Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe Leu 
            900                 905                 910         


Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro Glu 
        915                 920                 925             


Ala 
    


<210>  84
<211>  909
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  84

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu 
            500                 505                 510         


Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu 
        515                 520                 525             


His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp 
    530                 535                 540                 


Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His 
545                 550                 555                 560 


Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg 
                565                 570                 575     


His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val 
            580                 585                 590         


Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln 
        595                 600                 605             


Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val 
    610                 615                 620                 


His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val 
625                 630                 635                 640 


Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu 
                645                 650                 655     


Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr 
            660                 665                 670         


Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro 
        675                 680                 685             


Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro 
    690                 695                 700                 


Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr 
705                 710                 715                 720 


Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile 
                725                 730                 735     


Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val 
            740                 745                 750         


Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile 
        755                 760                 765             


Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser 
    770                 775                 780                 


Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg 
785                 790                 795                 800 


Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro 
                805                 810                 815     


Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val 
            820                 825                 830         


Arg His Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu 
        835                 840                 845             


Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val 
    850                 855                 860                 


Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe 
865                 870                 875                 880 


Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg 
                885                 890                 895     


Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu 
            900                 905                 


<210>  85
<211>  838
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  85

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu 
            500                 505                 510         


Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu 
        515                 520                 525             


His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp 
    530                 535                 540                 


Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His 
545                 550                 555                 560 


Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg 
                565                 570                 575     


His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val 
            580                 585                 590         


Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln 
        595                 600                 605             


Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val 
    610                 615                 620                 


His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val 
625                 630                 635                 640 


Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu 
                645                 650                 655     


Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr 
            660                 665                 670         


Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro 
        675                 680                 685             


Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro 
    690                 695                 700                 


Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr 
705                 710                 715                 720 


Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile 
                725                 730                 735     


Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val 
            740                 745                 750         


Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile 
        755                 760                 765             


Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser 
    770                 775                 780                 


Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg 
785                 790                 795                 800 


Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro 
                805                 810                 815     


Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val 
            820                 825                 830         


Arg His Pro Asp Ser His 
        835             


<210>  86
<211>  1000
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  86

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn 
        35                  40                  45              


Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys 
    50                  55                  60                  


Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu 
    130                 135                 140                 


Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln 
145                 150                 155                 160 


Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln 
                165                 170                 175     


Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala 
            180                 185                 190         


Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser 
        195                 200                 205             


Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro 
    210                 215                 220                 


Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln 
225                 230                 235                 240 


Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser 
                245                 250                 255     


Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro 
            260                 265                 270         


His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro 
        275                 280                 285             


Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg 
    290                 295                 300                 


Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg 
305                 310                 315                 320 


Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His 
                325                 330                 335     


Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp 
            340                 345                 350         


Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu 
        355                 360                 365             


Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val 
    370                 375                 380                 


Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile 
385                 390                 395                 400 


Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg 
                405                 410                 415     


Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly 
            420                 425                 430         


Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly 
        435                 440                 445             


Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro 
    450                 455                 460                 


Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly 
465                 470                 475                 480 


His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr 
                485                 490                 495     


Thr Tyr Glu Pro Glu Ala Met Lys Met Asp Lys Lys Thr Ile Val Trp 
            500                 505                 510         


Phe Arg Arg Asp Leu Arg Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala 
        515                 520                 525             


Ala His Glu Gly Ser Val Phe Pro Val Phe Ile Trp Cys Pro Glu Glu 
    530                 535                 540                 


Glu Gly Gln Phe Tyr Pro Gly Arg Ala Ser Arg Trp Trp Met Lys Gln 
545                 550                 555                 560 


Ser Leu Ala His Leu Ser Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu 
                565                 570                 575     


Thr Leu Ile Lys Thr His Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile 
            580                 585                 590         


Arg Val Thr Gly Ala Thr Lys Val Val Phe Asn His Leu Tyr Asp Pro 
        595                 600                 605             


Val Ser Leu Val Arg Asp His Thr Val Lys Glu Lys Leu Val Glu Arg 
    610                 615                 620                 


Gly Ile Ser Val Gln Ser Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp 
625                 630                 635                 640 


Glu Ile Tyr Cys Glu Lys Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr 
                645                 650                 655     


Trp Lys Lys Cys Leu Asp Met Ser Ile Glu Ser Val Met Leu Pro Pro 
            660                 665                 670         


Pro Trp Arg Leu Met Pro Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala 
        675                 680                 685             


Cys Ser Ile Glu Glu Leu Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser 
    690                 695                 700                 


Asn Ala Leu Leu Thr Arg Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp 
705                 710                 715                 720 


Lys Leu Leu Asn Glu Phe Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys 
                725                 730                 735     


Asn Ser Lys Lys Val Val Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr 
            740                 745                 750         


Leu His Phe Gly Glu Ile Ser Val Arg His Val Phe Gln Cys Ala Arg 
        755                 760                 765             


Met Lys Gln Ile Ile Trp Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu 
    770                 775                 780                 


Ser Ala Asp Leu Phe Leu Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg 
785                 790                 795                 800 


Tyr Ile Cys Phe Asn Phe Pro Phe Thr His Glu Gln Ser Leu Leu Ser 
                805                 810                 815     


His Leu Arg Phe Phe Pro Trp Asp Ala Asp Val Asp Lys Phe Lys Ala 
            820                 825                 830         


Trp Arg Gln Gly Arg Thr Gly Tyr Pro Leu Val Asp Ala Gly Met Arg 
        835                 840                 845             


Glu Leu Trp Ala Thr Gly Trp Met His Asn Arg Ile Arg Val Ile Val 
    850                 855                 860                 


Ser Ser Phe Ala Val Lys Phe Leu Leu Leu Pro Trp Lys Trp Gly Met 
865                 870                 875                 880 


Lys Tyr Phe Trp Asp Thr Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile 
                885                 890                 895     


Leu Gly Trp Gln Tyr Ile Ser Gly Ser Ile Pro Asp Gly His Glu Leu 
            900                 905                 910         


Asp Arg Leu Asp Asn Pro Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu 
        915                 920                 925             


Gly Glu Tyr Ile Arg Gln Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr 
    930                 935                 940                 


Glu Trp Ile His His Pro Trp Asp Ala Pro Leu Thr Val Leu Lys Ala 
945                 950                 955                 960 


Ser Gly Val Glu Leu Gly Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile 
                965                 970                 975     


Asp Thr Ala Arg Glu Leu Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly 
            980                 985                 990         


Ala Gln Ile Met Ile Gly Ala Ala  
        995                 1000 


<210>  87
<211>  862
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  87

Met Gly Phe Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu 
1               5                   10                  15      


Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser 
            20                  25                  30          


Gly Thr Phe Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His 
        35                  40                  45              


Leu Glu Glu Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro 
    50                  55                  60                  


Glu Gln Glu Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val 
65                  70                  75                  80  


Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala 
                85                  90                  95      


Pro Ala Asp Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser 
            100                 105                 110         


Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro 
        115                 120                 125             


Val Thr Gly Ile Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro 
    130                 135                 140                 


Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln 
145                 150                 155                 160 


Arg Asp Gln Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg 
                165                 170                 175     


Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro 
            180                 185                 190         


Arg Arg Met Val Arg His Pro Asp Ser His Gln Leu Phe Ile Gly Asn 
        195                 200                 205             


Leu Pro His Glu Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser 
    210                 215                 220                 


Tyr Gly Asn Val Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro 
225                 230                 235                 240 


Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val 
                245                 250                 255     


Leu Ser Asn Arg Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val 
            260                 265                 270         


Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn 
        275                 280                 285             


Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met 
    290                 295                 300                 


Arg Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val 
305                 310                 315                 320 


Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg 
                325                 330                 335     


Ala Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile 
            340                 345                 350         


Arg Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala Met Lys Met Asp 
        355                 360                 365             


Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg Ile Glu Asp Asn 
    370                 375                 380                 


Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val Phe Pro Val Phe 
385                 390                 395                 400 


Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro Gly Arg Ala Ser 
                405                 410                 415     


Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser Gln Ser Leu Lys 
            420                 425                 430         


Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His Asn Thr Ile Ser 
        435                 440                 445             


Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr Lys Val Val Phe 
    450                 455                 460                 


Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp His Thr Val Lys 
465                 470                 475                 480 


Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser Tyr Asn Gly Asp 
                485                 490                 495     


Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys Gly Lys Pro Phe 
            500                 505                 510         


Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp Met Ser Ile Glu 
        515                 520                 525             


Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro Ile Thr Ala Ala 
    530                 535                 540                 


Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu Gly Leu Glu Asn 
545                 550                 555                 560 


Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg Ala Trp Ser Pro 
                565                 570                 575     


Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe Ile Glu Lys Gln 
            580                 585                 590         


Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val Gly Asn Ser Thr 
        595                 600                 605             


Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile Ser Val Arg His 
    610                 615                 620                 


Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp Ala Arg Asp Lys 
625                 630                 635                 640 


Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu Arg Gly Ile Gly 
                645                 650                 655     


Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe Pro Phe Thr His 
            660                 665                 670         


Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro Trp Asp Ala Asp 
        675                 680                 685             


Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr Gly Tyr Pro Leu 
    690                 695                 700                 


Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly Trp Met His Asn 
705                 710                 715                 720 


Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys Phe Leu Leu Leu 
                725                 730                 735     


Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr Leu Leu Asp Ala 
            740                 745                 750         


Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile Ser Gly Ser Ile 
        755                 760                 765             


Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro Ala Leu Gln Gly 
    770                 775                 780                 


Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln Trp Leu Pro Glu 
785                 790                 795                 800 


Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro Trp Asp Ala Pro 
                805                 810                 815     


Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly Thr Asn Tyr Ala 
            820                 825                 830         


Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu Leu Ala Lys Ala 
        835                 840                 845             


Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly Ala Ala 
    850                 855                 860         


<210>  88
<211>  918
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  88

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn 
        35                  40                  45              


Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys 
    50                  55                  60                  


Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Thr Ala Pro Glu Asp 
    130                 135                 140                 


Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val 
145                 150                 155                 160 


Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn 
                165                 170                 175     


Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro His Val 
            180                 185                 190         


Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser 
        195                 200                 205             


Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln 
    210                 215                 220                 


Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala 
225                 230                 235                 240 


Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His Pro Asp 
                245                 250                 255     


Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser 
            260                 265                 270         


Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg 
        275                 280                 285             


Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp 
    290                 295                 300                 


Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe 
305                 310                 315                 320 


Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala 
                325                 330                 335     


Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro 
            340                 345                 350         


Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met 
        355                 360                 365             


Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln 
    370                 375                 380                 


Lys Leu Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly His Ser 
385                 390                 395                 400 


Cys Phe Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr 
                405                 410                 415     


Glu Pro Glu Ala Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg 
            420                 425                 430         


Arg Asp Leu Arg Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His 
        435                 440                 445             


Glu Gly Ser Val Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly 
    450                 455                 460                 


Gln Phe Tyr Pro Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu 
465                 470                 475                 480 


Ala His Leu Ser Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu 
                485                 490                 495     


Ile Lys Thr His Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val 
            500                 505                 510         


Thr Gly Ala Thr Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser 
        515                 520                 525             


Leu Val Arg Asp His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile 
    530                 535                 540                 


Ser Val Gln Ser Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile 
545                 550                 555                 560 


Tyr Cys Glu Lys Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys 
                565                 570                 575     


Lys Cys Leu Asp Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp 
            580                 585                 590         


Arg Leu Met Pro Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser 
        595                 600                 605             


Ile Glu Glu Leu Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala 
    610                 615                 620                 


Leu Leu Thr Arg Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu 
625                 630                 635                 640 


Leu Asn Glu Phe Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser 
                645                 650                 655     


Lys Lys Val Val Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His 
            660                 665                 670         


Phe Gly Glu Ile Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys 
        675                 680                 685             


Gln Ile Ile Trp Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala 
    690                 695                 700                 


Asp Leu Phe Leu Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile 
705                 710                 715                 720 


Cys Phe Asn Phe Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu 
                725                 730                 735     


Arg Phe Phe Pro Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg 
            740                 745                 750         


Gln Gly Arg Thr Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu 
        755                 760                 765             


Trp Ala Thr Gly Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser 
    770                 775                 780                 


Phe Ala Val Lys Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr 
785                 790                 795                 800 


Phe Trp Asp Thr Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly 
                805                 810                 815     


Trp Gln Tyr Ile Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg 
            820                 825                 830         


Leu Asp Asn Pro Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu 
        835                 840                 845             


Tyr Ile Arg Gln Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp 
    850                 855                 860                 


Ile His His Pro Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly 
865                 870                 875                 880 


Val Glu Leu Gly Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr 
                885                 890                 895     


Ala Arg Glu Leu Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln 
            900                 905                 910         


Ile Met Ile Gly Ala Ala 
        915             


<210>  89
<211>  881
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  89

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn 
        35                  40                  45              


Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys 
    50                  55                  60                  


Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu 
    130                 135                 140                 


Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln 
145                 150                 155                 160 


Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln 
                165                 170                 175     


Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala 
            180                 185                 190         


Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser 
        195                 200                 205             


Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Gln Leu Phe 
    210                 215                 220                 


Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu Lys Asp Phe 
225                 230                 235                 240 


Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn Ser Gly Gly 
                245                 250                 255     


Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro Val 
            260                 265                 270         


Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly Glu Val Arg 
        275                 280                 285             


Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg 
    290                 295                 300                 


Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly 
305                 310                 315                 320 


Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly 
                325                 330                 335     


Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met 
            340                 345                 350         


Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu 
        355                 360                 365             


Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala Met 
    370                 375                 380                 


Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg Ile 
385                 390                 395                 400 


Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val Phe 
                405                 410                 415     


Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro Gly 
            420                 425                 430         


Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser Gln 
        435                 440                 445             


Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His Asn 
    450                 455                 460                 


Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr Lys 
465                 470                 475                 480 


Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp His 
                485                 490                 495     


Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser Tyr 
            500                 505                 510         


Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys Gly 
        515                 520                 525             


Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp Met 
    530                 535                 540                 


Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro Ile 
545                 550                 555                 560 


Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu Gly 
                565                 570                 575     


Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg Ala 
            580                 585                 590         


Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe Ile 
        595                 600                 605             


Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val Gly 
    610                 615                 620                 


Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile Ser 
625                 630                 635                 640 


Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp Ala 
                645                 650                 655     


Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu Arg 
            660                 665                 670         


Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe Pro 
        675                 680                 685             


Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro Trp 
    690                 695                 700                 


Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr Gly 
705                 710                 715                 720 


Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly Trp 
                725                 730                 735     


Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys Phe 
            740                 745                 750         


Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr Leu 
        755                 760                 765             


Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile Ser 
    770                 775                 780                 


Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro Ala 
785                 790                 795                 800 


Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln Trp 
                805                 810                 815     


Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro Trp 
            820                 825                 830         


Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly Thr 
        835                 840                 845             


Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu Leu 
    850                 855                 860                 


Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly Ala 
865                 870                 875                 880 


Ala 
    


<210>  90
<211>  929
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  90

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn 
        35                  40                  45              


Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys 
    50                  55                  60                  


Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu 
    130                 135                 140                 


Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln 
145                 150                 155                 160 


Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln 
                165                 170                 175     


Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala 
            180                 185                 190         


Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser 
        195                 200                 205             


Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro 
    210                 215                 220                 


Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln 
225                 230                 235                 240 


Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser 
                245                 250                 255     


Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro 
            260                 265                 270         


His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro 
        275                 280                 285             


Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg 
    290                 295                 300                 


Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg 
305                 310                 315                 320 


Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His 
                325                 330                 335     


Pro Asp Ser His Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg 
            340                 345                 350         


Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly 
        355                 360                 365             


Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly 
    370                 375                 380                 


Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met 
385                 390                 395                 400 


Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu 
                405                 410                 415     


Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala Met 
            420                 425                 430         


Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg Ile 
        435                 440                 445             


Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val Phe 
    450                 455                 460                 


Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro Gly 
465                 470                 475                 480 


Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser Gln 
                485                 490                 495     


Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His Asn 
            500                 505                 510         


Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr Lys 
        515                 520                 525             


Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp His 
    530                 535                 540                 


Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser Tyr 
545                 550                 555                 560 


Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys Gly 
                565                 570                 575     


Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp Met 
            580                 585                 590         


Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro Ile 
        595                 600                 605             


Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu Gly 
    610                 615                 620                 


Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg Ala 
625                 630                 635                 640 


Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe Ile 
                645                 650                 655     


Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val Gly 
            660                 665                 670         


Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile Ser 
        675                 680                 685             


Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp Ala 
    690                 695                 700                 


Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu Arg 
705                 710                 715                 720 


Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe Pro 
                725                 730                 735     


Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro Trp 
            740                 745                 750         


Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr Gly 
        755                 760                 765             


Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly Trp 
    770                 775                 780                 


Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys Phe 
785                 790                 795                 800 


Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr Leu 
                805                 810                 815     


Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile Ser 
            820                 825                 830         


Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro Ala 
        835                 840                 845             


Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln Trp 
    850                 855                 860                 


Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro Trp 
865                 870                 875                 880 


Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly Thr 
                885                 890                 895     


Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu Leu 
            900                 905                 910         


Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly Ala 
        915                 920                 925             


Ala 
    


<210>  91
<211>  909
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  91

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn 
        35                  40                  45              


Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys 
    50                  55                  60                  


Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu 
    130                 135                 140                 


Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln 
145                 150                 155                 160 


Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln 
                165                 170                 175     


Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala 
            180                 185                 190         


Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser 
        195                 200                 205             


Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro 
    210                 215                 220                 


Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln 
225                 230                 235                 240 


Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser 
                245                 250                 255     


Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro 
            260                 265                 270         


His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro 
        275                 280                 285             


Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg 
    290                 295                 300                 


Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg 
305                 310                 315                 320 


Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His 
                325                 330                 335     


Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp 
            340                 345                 350         


Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu 
        355                 360                 365             


Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val 
    370                 375                 380                 


Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile 
385                 390                 395                 400 


Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Met Lys Met Asp Lys 
                405                 410                 415     


Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg Ile Glu Asp Asn Pro 
            420                 425                 430         


Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val Phe Pro Val Phe Ile 
        435                 440                 445             


Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro Gly Arg Ala Ser Arg 
    450                 455                 460                 


Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser Gln Ser Leu Lys Ala 
465                 470                 475                 480 


Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His Asn Thr Ile Ser Ala 
                485                 490                 495     


Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr Lys Val Val Phe Asn 
            500                 505                 510         


His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp His Thr Val Lys Glu 
        515                 520                 525             


Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser Tyr Asn Gly Asp Leu 
    530                 535                 540                 


Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys Gly Lys Pro Phe Thr 
545                 550                 555                 560 


Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp Met Ser Ile Glu Ser 
                565                 570                 575     


Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro Ile Thr Ala Ala Ala 
            580                 585                 590         


Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu Gly Leu Glu Asn Glu 
        595                 600                 605             


Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg Ala Trp Ser Pro Gly 
    610                 615                 620                 


Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe Ile Glu Lys Gln Leu 
625                 630                 635                 640 


Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val Gly Asn Ser Thr Ser 
                645                 650                 655     


Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile Ser Val Arg His Val 
            660                 665                 670         


Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp Ala Arg Asp Lys Asn 
        675                 680                 685             


Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu Arg Gly Ile Gly Leu 
    690                 695                 700                 


Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe Pro Phe Thr His Glu 
705                 710                 715                 720 


Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro Trp Asp Ala Asp Val 
                725                 730                 735     


Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr Gly Tyr Pro Leu Val 
            740                 745                 750         


Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly Trp Met His Asn Arg 
        755                 760                 765             


Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys Phe Leu Leu Leu Pro 
    770                 775                 780                 


Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr Leu Leu Asp Ala Asp 
785                 790                 795                 800 


Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile Ser Gly Ser Ile Pro 
                805                 810                 815     


Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro Ala Leu Gln Gly Ala 
            820                 825                 830         


Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln Trp Leu Pro Glu Leu 
        835                 840                 845             


Ala Arg Leu Pro Thr Glu Trp Ile His His Pro Trp Asp Ala Pro Leu 
    850                 855                 860                 


Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly Thr Asn Tyr Ala Lys 
865                 870                 875                 880 


Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu Leu Ala Lys Ala Ile 
                885                 890                 895     


Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly Ala Ala 
            900                 905                 


<210>  92
<211>  838
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  92

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn 
        35                  40                  45              


Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys 
    50                  55                  60                  


Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu 
    130                 135                 140                 


Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln 
145                 150                 155                 160 


Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln 
                165                 170                 175     


Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala 
            180                 185                 190         


Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser 
        195                 200                 205             


Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro 
    210                 215                 220                 


Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln 
225                 230                 235                 240 


Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser 
                245                 250                 255     


Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro 
            260                 265                 270         


His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro 
        275                 280                 285             


Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg 
    290                 295                 300                 


Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg 
305                 310                 315                 320 


Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His 
                325                 330                 335     


Pro Asp Ser His Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg 
            340                 345                 350         


Arg Asp Leu Arg Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His 
        355                 360                 365             


Glu Gly Ser Val Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly 
    370                 375                 380                 


Gln Phe Tyr Pro Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu 
385                 390                 395                 400 


Ala His Leu Ser Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu 
                405                 410                 415     


Ile Lys Thr His Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val 
            420                 425                 430         


Thr Gly Ala Thr Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser 
        435                 440                 445             


Leu Val Arg Asp His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile 
    450                 455                 460                 


Ser Val Gln Ser Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile 
465                 470                 475                 480 


Tyr Cys Glu Lys Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys 
                485                 490                 495     


Lys Cys Leu Asp Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp 
            500                 505                 510         


Arg Leu Met Pro Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser 
        515                 520                 525             


Ile Glu Glu Leu Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala 
    530                 535                 540                 


Leu Leu Thr Arg Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu 
545                 550                 555                 560 


Leu Asn Glu Phe Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser 
                565                 570                 575     


Lys Lys Val Val Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His 
            580                 585                 590         


Phe Gly Glu Ile Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys 
        595                 600                 605             


Gln Ile Ile Trp Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala 
    610                 615                 620                 


Asp Leu Phe Leu Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile 
625                 630                 635                 640 


Cys Phe Asn Phe Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu 
                645                 650                 655     


Arg Phe Phe Pro Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg 
            660                 665                 670         


Gln Gly Arg Thr Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu 
        675                 680                 685             


Trp Ala Thr Gly Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser 
    690                 695                 700                 


Phe Ala Val Lys Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr 
705                 710                 715                 720 


Phe Trp Asp Thr Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly 
                725                 730                 735     


Trp Gln Tyr Ile Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg 
            740                 745                 750         


Leu Asp Asn Pro Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu 
        755                 760                 765             


Tyr Ile Arg Gln Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp 
    770                 775                 780                 


Ile His His Pro Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly 
785                 790                 795                 800 


Val Glu Leu Gly Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr 
                805                 810                 815     


Ala Arg Glu Leu Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln 
            820                 825                 830         


Ile Met Ile Gly Ala Ala 
        835             


<210>  93
<211>  1000
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  93

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Glu Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu 
            500                 505                 510         


Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu 
        515                 520                 525             


His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp 
    530                 535                 540                 


Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His 
545                 550                 555                 560 


Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg 
                565                 570                 575     


His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val 
            580                 585                 590         


Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln 
        595                 600                 605             


Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val 
    610                 615                 620                 


His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val 
625                 630                 635                 640 


Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu 
                645                 650                 655     


Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr 
            660                 665                 670         


Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro 
        675                 680                 685             


Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro 
    690                 695                 700                 


Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr 
705                 710                 715                 720 


Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile 
                725                 730                 735     


Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val 
            740                 745                 750         


Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile 
        755                 760                 765             


Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser 
    770                 775                 780                 


Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg 
785                 790                 795                 800 


Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro 
                805                 810                 815     


Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val 
            820                 825                 830         


Arg His Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu 
        835                 840                 845             


Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val 
    850                 855                 860                 


Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe 
865                 870                 875                 880 


Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg 
                885                 890                 895     


Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys 
            900                 905                 910         


Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly 
        915                 920                 925             


Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro 
    930                 935                 940                 


Arg Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu 
945                 950                 955                 960 


Ala Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala Trp Leu Glu 
                965                 970                 975     


His Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg Ser Gln Phe 
            980                 985                 990         


His Thr Thr Tyr Glu Pro Glu Ala  
        995                 1000 


<210>  94
<211>  862
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  94

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Glu Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Met Gly Phe Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu 
            500                 505                 510         


Val Glu Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp 
        515                 520                 525             


Asp Ser Gly Thr Phe Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu 
    530                 535                 540                 


Glu His Leu Glu Glu Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro 
545                 550                 555                 560 


Glu Pro Glu Gln Glu Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu 
                565                 570                 575     


Pro Val Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser 
            580                 585                 590         


Pro Ala Pro Ala Asp Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr 
        595                 600                 605             


Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala 
    610                 615                 620                 


Val Pro Val Thr Gly Ile Pro Pro His Val Val Lys Val Pro Ala Ser 
625                 630                 635                 640 


Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg 
                645                 650                 655     


Pro Gln Arg Asp Gln Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro 
            660                 665                 670         


Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile 
        675                 680                 685             


Glu Pro Arg Arg Met Val Arg His Pro Asp Ser His Gln Leu Phe Ile 
    690                 695                 700                 


Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu Lys Asp Phe Phe 
705                 710                 715                 720 


Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn Ser Gly Gly Lys 
                725                 730                 735     


Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro Val Gln 
            740                 745                 750         


Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly Glu Val Arg Leu 
        755                 760                 765             


Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg 
    770                 775                 780                 


Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly 
785                 790                 795                 800 


Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly Phe 
                805                 810                 815     


Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met Ala 
            820                 825                 830         


Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu Ile 
        835                 840                 845             


Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala 
    850                 855                 860         


<210>  95
<211>  918
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  95

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Glu Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu 
            500                 505                 510         


Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu 
        515                 520                 525             


His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp 
    530                 535                 540                 


Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His 
545                 550                 555                 560 


Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg 
                565                 570                 575     


His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val 
            580                 585                 590         


Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln 
        595                 600                 605             


Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val 
    610                 615                 620                 


His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Thr Ala Pro 
625                 630                 635                 640 


Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln 
                645                 650                 655     


Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser 
            660                 665                 670         


Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro 
        675                 680                 685             


His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro 
    690                 695                 700                 


Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg 
705                 710                 715                 720 


Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg 
                725                 730                 735     


Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His 
            740                 745                 750         


Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp 
        755                 760                 765             


Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu 
    770                 775                 780                 


Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val 
785                 790                 795                 800 


Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile 
                805                 810                 815     


Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg 
            820                 825                 830         


Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly 
        835                 840                 845             


Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly 
    850                 855                 860                 


Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro 
865                 870                 875                 880 


Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly 
                885                 890                 895     


His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr 
            900                 905                 910         


Thr Tyr Glu Pro Glu Ala 
        915             


<210>  96
<211>  881
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  96

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Glu Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu 
            500                 505                 510         


Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu 
        515                 520                 525             


His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp 
    530                 535                 540                 


Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His 
545                 550                 555                 560 


Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg 
                565                 570                 575     


His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val 
            580                 585                 590         


Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln 
        595                 600                 605             


Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val 
    610                 615                 620                 


His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val 
625                 630                 635                 640 


Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu 
                645                 650                 655     


Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr 
            660                 665                 670         


Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro 
        675                 680                 685             


Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro 
    690                 695                 700                 


Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Gln 
705                 710                 715                 720 


Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu Lys 
                725                 730                 735     


Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn Ser 
            740                 745                 750         


Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu 
        755                 760                 765             


Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly Glu 
    770                 775                 780                 


Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly 
785                 790                 795                 800 


Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly 
                805                 810                 815     


Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln Lys 
            820                 825                 830         


Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile 
        835                 840                 845             


Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe Leu 
    850                 855                 860                 


Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro Glu 
865                 870                 875                 880 


Ala 
    


<210>  97
<211>  929
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  97

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Glu Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu 
            500                 505                 510         


Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu 
        515                 520                 525             


His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp 
    530                 535                 540                 


Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His 
545                 550                 555                 560 


Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg 
                565                 570                 575     


His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val 
            580                 585                 590         


Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln 
        595                 600                 605             


Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val 
    610                 615                 620                 


His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val 
625                 630                 635                 640 


Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu 
                645                 650                 655     


Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr 
            660                 665                 670         


Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro 
        675                 680                 685             


Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro 
    690                 695                 700                 


Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr 
705                 710                 715                 720 


Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile 
                725                 730                 735     


Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val 
            740                 745                 750         


Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile 
        755                 760                 765             


Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser 
    770                 775                 780                 


Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg 
785                 790                 795                 800 


Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro 
                805                 810                 815     


Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val 
            820                 825                 830         


Arg His Pro Asp Ser His Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly 
        835                 840                 845             


Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly 
    850                 855                 860                 


Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln Lys 
865                 870                 875                 880 


Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile 
                885                 890                 895     


Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe Leu 
            900                 905                 910         


Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro Glu 
        915                 920                 925             


Ala 
    


<210>  98
<211>  909
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  98

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Glu Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu 
            500                 505                 510         


Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu 
        515                 520                 525             


His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp 
    530                 535                 540                 


Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His 
545                 550                 555                 560 


Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg 
                565                 570                 575     


His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val 
            580                 585                 590         


Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln 
        595                 600                 605             


Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val 
    610                 615                 620                 


His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val 
625                 630                 635                 640 


Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu 
                645                 650                 655     


Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr 
            660                 665                 670         


Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro 
        675                 680                 685             


Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro 
    690                 695                 700                 


Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr 
705                 710                 715                 720 


Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile 
                725                 730                 735     


Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val 
            740                 745                 750         


Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile 
        755                 760                 765             


Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser 
    770                 775                 780                 


Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg 
785                 790                 795                 800 


Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro 
                805                 810                 815     


Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val 
            820                 825                 830         


Arg His Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu 
        835                 840                 845             


Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val 
    850                 855                 860                 


Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe 
865                 870                 875                 880 


Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg 
                885                 890                 895     


Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu 
            900                 905                 


<210>  99
<211>  838
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  99

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Glu Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu 
            500                 505                 510         


Phe Val Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu 
        515                 520                 525             


His Arg Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp 
    530                 535                 540                 


Ser Asn Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His 
545                 550                 555                 560 


Arg Lys Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg 
                565                 570                 575     


His Val Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val 
            580                 585                 590         


Met Gly Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln 
        595                 600                 605             


Thr Phe Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val 
    610                 615                 620                 


His Asn Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val 
625                 630                 635                 640 


Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu 
                645                 650                 655     


Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr 
            660                 665                 670         


Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro 
        675                 680                 685             


Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro 
    690                 695                 700                 


Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr 
705                 710                 715                 720 


Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile 
                725                 730                 735     


Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val 
            740                 745                 750         


Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile 
        755                 760                 765             


Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser 
    770                 775                 780                 


Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg 
785                 790                 795                 800 


Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro 
                805                 810                 815     


Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val 
            820                 825                 830         


Arg His Pro Asp Ser His 
        835             


<210>  100
<211>  1000
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  100

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn 
        35                  40                  45              


Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys 
    50                  55                  60                  


Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu 
    130                 135                 140                 


Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln 
145                 150                 155                 160 


Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln 
                165                 170                 175     


Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala 
            180                 185                 190         


Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser 
        195                 200                 205             


Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro 
    210                 215                 220                 


Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln 
225                 230                 235                 240 


Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser 
                245                 250                 255     


Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro 
            260                 265                 270         


His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro 
        275                 280                 285             


Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg 
    290                 295                 300                 


Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg 
305                 310                 315                 320 


Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His 
                325                 330                 335     


Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp 
            340                 345                 350         


Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu 
        355                 360                 365             


Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val 
    370                 375                 380                 


Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile 
385                 390                 395                 400 


Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg 
                405                 410                 415     


Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly 
            420                 425                 430         


Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly 
        435                 440                 445             


Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro 
    450                 455                 460                 


Arg Gln Lys Leu Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly 
465                 470                 475                 480 


His Ser Cys Phe Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr 
                485                 490                 495     


Thr Tyr Glu Pro Glu Ala Met Lys Met Asp Lys Lys Thr Ile Val Trp 
            500                 505                 510         


Phe Arg Arg Asp Leu Arg Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala 
        515                 520                 525             


Ala His Glu Gly Ser Val Phe Pro Val Phe Ile Trp Cys Pro Glu Glu 
    530                 535                 540                 


Glu Gly Gln Phe Tyr Pro Gly Arg Ala Ser Arg Trp Trp Met Lys Gln 
545                 550                 555                 560 


Ser Leu Ala His Leu Ser Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu 
                565                 570                 575     


Thr Leu Ile Lys Thr His Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile 
            580                 585                 590         


Arg Val Thr Gly Ala Thr Lys Val Val Phe Asn His Leu Tyr Asp Pro 
        595                 600                 605             


Val Ser Leu Val Arg Asp His Thr Val Lys Glu Lys Leu Val Glu Arg 
    610                 615                 620                 


Gly Ile Ser Val Gln Ser Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp 
625                 630                 635                 640 


Glu Ile Tyr Cys Glu Lys Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr 
                645                 650                 655     


Trp Lys Lys Cys Leu Asp Met Ser Ile Glu Ser Val Met Leu Pro Pro 
            660                 665                 670         


Pro Trp Arg Leu Met Pro Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala 
        675                 680                 685             


Cys Ser Ile Glu Glu Leu Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser 
    690                 695                 700                 


Asn Ala Leu Leu Thr Arg Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp 
705                 710                 715                 720 


Lys Leu Leu Asn Glu Phe Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys 
                725                 730                 735     


Asn Ser Lys Lys Val Val Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr 
            740                 745                 750         


Leu His Phe Gly Glu Ile Ser Val Arg His Val Phe Gln Cys Ala Arg 
        755                 760                 765             


Met Lys Gln Ile Ile Trp Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu 
    770                 775                 780                 


Ser Ala Asp Leu Phe Leu Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg 
785                 790                 795                 800 


Tyr Ile Cys Phe Asn Phe Pro Phe Thr His Glu Gln Ser Leu Leu Ser 
                805                 810                 815     


His Leu Arg Phe Phe Pro Trp Asp Ala Asp Val Asp Lys Phe Lys Ala 
            820                 825                 830         


Trp Arg Gln Gly Arg Thr Gly Tyr Pro Leu Val Asp Ala Gly Met Arg 
        835                 840                 845             


Glu Leu Trp Ala Thr Gly Trp Met His Asn Arg Ile Arg Val Ile Val 
    850                 855                 860                 


Ser Ser Phe Ala Val Lys Phe Leu Leu Leu Pro Trp Lys Trp Gly Met 
865                 870                 875                 880 


Lys Tyr Phe Trp Asp Thr Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile 
                885                 890                 895     


Leu Gly Trp Gln Tyr Ile Ser Gly Ser Ile Pro Asp Gly His Glu Leu 
            900                 905                 910         


Asp Arg Leu Asp Asn Pro Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu 
        915                 920                 925             


Gly Glu Tyr Ile Arg Gln Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr 
    930                 935                 940                 


Glu Trp Ile His His Pro Trp Asp Ala Pro Leu Thr Val Leu Lys Ala 
945                 950                 955                 960 


Ser Gly Val Glu Leu Gly Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile 
                965                 970                 975     


Asp Thr Ala Arg Glu Leu Leu Ala Lys Ala Ile Ser Arg Thr Arg Glu 
            980                 985                 990         


Ala Gln Ile Met Ile Gly Ala Ala  
        995                 1000 


<210>  101
<211>  862
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  101

Met Gly Phe Val Thr Glu Pro Gln Glu Glu Ser Glu Glu Glu Val Glu 
1               5                   10                  15      


Glu Pro Glu Glu Arg Gln Gln Thr Pro Glu Val Val Pro Asp Asp Ser 
            20                  25                  30          


Gly Thr Phe Tyr Asp Gln Ala Val Val Ser Asn Asp Met Glu Glu His 
        35                  40                  45              


Leu Glu Glu Pro Val Ala Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro 
    50                  55                  60                  


Glu Gln Glu Pro Val Ser Glu Ile Gln Glu Glu Lys Pro Glu Pro Val 
65                  70                  75                  80  


Leu Glu Glu Thr Ala Pro Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala 
                85                  90                  95      


Pro Ala Asp Ile Ala Gln Thr Val Gln Glu Asp Leu Arg Thr Phe Ser 
            100                 105                 110         


Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro Ser Gly Ala Val Pro 
        115                 120                 125             


Val Thr Gly Ile Pro Pro His Val Val Lys Val Pro Ala Ser Gln Pro 
    130                 135                 140                 


Arg Pro Glu Ser Lys Pro Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln 
145                 150                 155                 160 


Arg Asp Gln Arg Val Arg Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg 
                165                 170                 175     


Gly Pro Arg Pro Ile Arg Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro 
            180                 185                 190         


Arg Arg Met Val Arg His Pro Asp Ser His Gln Leu Phe Ile Gly Asn 
        195                 200                 205             


Leu Pro His Glu Val Asp Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser 
    210                 215                 220                 


Tyr Gly Asn Val Val Glu Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro 
225                 230                 235                 240 


Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro Val Gln Lys Val 
                245                 250                 255     


Leu Ser Asn Arg Pro Ile Met Phe Arg Gly Glu Val Arg Leu Asn Val 
            260                 265                 270         


Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn 
        275                 280                 285             


Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly Gly Gly Met 
    290                 295                 300                 


Arg Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly Phe Gly Val 
305                 310                 315                 320 


Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met Ala Arg Arg 
                325                 330                 335     


Ala Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu Ile Val Ile 
            340                 345                 350         


Arg Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala Met Lys Met Asp 
        355                 360                 365             


Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg Ile Glu Asp Asn 
    370                 375                 380                 


Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val Phe Pro Val Phe 
385                 390                 395                 400 


Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro Gly Arg Ala Ser 
                405                 410                 415     


Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser Gln Ser Leu Lys 
            420                 425                 430         


Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His Asn Thr Ile Ser 
        435                 440                 445             


Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr Lys Val Val Phe 
    450                 455                 460                 


Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp His Thr Val Lys 
465                 470                 475                 480 


Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser Tyr Asn Gly Asp 
                485                 490                 495     


Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys Gly Lys Pro Phe 
            500                 505                 510         


Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp Met Ser Ile Glu 
        515                 520                 525             


Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro Ile Thr Ala Ala 
    530                 535                 540                 


Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu Gly Leu Glu Asn 
545                 550                 555                 560 


Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg Ala Trp Ser Pro 
                565                 570                 575     


Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe Ile Glu Lys Gln 
            580                 585                 590         


Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val Gly Asn Ser Thr 
        595                 600                 605             


Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile Ser Val Arg His 
    610                 615                 620                 


Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp Ala Arg Asp Lys 
625                 630                 635                 640 


Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu Arg Gly Ile Gly 
                645                 650                 655     


Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe Pro Phe Thr His 
            660                 665                 670         


Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro Trp Asp Ala Asp 
        675                 680                 685             


Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr Gly Tyr Pro Leu 
    690                 695                 700                 


Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly Trp Met His Asn 
705                 710                 715                 720 


Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys Phe Leu Leu Leu 
                725                 730                 735     


Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr Leu Leu Asp Ala 
            740                 745                 750         


Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile Ser Gly Ser Ile 
        755                 760                 765             


Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro Ala Leu Gln Gly 
    770                 775                 780                 


Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln Trp Leu Pro Glu 
785                 790                 795                 800 


Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro Trp Asp Ala Pro 
                805                 810                 815     


Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly Thr Asn Tyr Ala 
            820                 825                 830         


Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu Leu Ala Lys Ala 
        835                 840                 845             


Ile Ser Arg Thr Arg Glu Ala Gln Ile Met Ile Gly Ala Ala 
    850                 855                 860         


<210>  102
<211>  918
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  102

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn 
        35                  40                  45              


Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys 
    50                  55                  60                  


Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Thr Ala Pro Glu Asp 
    130                 135                 140                 


Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln Thr Val 
145                 150                 155                 160 


Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser Lys Asn 
                165                 170                 175     


Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro His Val 
            180                 185                 190         


Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro Glu Ser 
        195                 200                 205             


Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg Glu Gln 
    210                 215                 220                 


Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg Glu Ala 
225                 230                 235                 240 


Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His Pro Asp 
                245                 250                 255     


Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser 
            260                 265                 270         


Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg 
        275                 280                 285             


Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp 
    290                 295                 300                 


Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe 
305                 310                 315                 320 


Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala 
                325                 330                 335     


Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro 
            340                 345                 350         


Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met 
        355                 360                 365             


Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln 
    370                 375                 380                 


Lys Leu Ile Pro Met Ala Arg Arg Ala Trp Leu Glu His Gly His Ser 
385                 390                 395                 400 


Cys Phe Leu Cys Glu Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr 
                405                 410                 415     


Glu Pro Glu Ala Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg 
            420                 425                 430         


Arg Asp Leu Arg Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His 
        435                 440                 445             


Glu Gly Ser Val Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly 
    450                 455                 460                 


Gln Phe Tyr Pro Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu 
465                 470                 475                 480 


Ala His Leu Ser Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu 
                485                 490                 495     


Ile Lys Thr His Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val 
            500                 505                 510         


Thr Gly Ala Thr Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser 
        515                 520                 525             


Leu Val Arg Asp His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile 
    530                 535                 540                 


Ser Val Gln Ser Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile 
545                 550                 555                 560 


Tyr Cys Glu Lys Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys 
                565                 570                 575     


Lys Cys Leu Asp Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp 
            580                 585                 590         


Arg Leu Met Pro Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser 
        595                 600                 605             


Ile Glu Glu Leu Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala 
    610                 615                 620                 


Leu Leu Thr Arg Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu 
625                 630                 635                 640 


Leu Asn Glu Phe Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser 
                645                 650                 655     


Lys Lys Val Val Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His 
            660                 665                 670         


Phe Gly Glu Ile Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys 
        675                 680                 685             


Gln Ile Ile Trp Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala 
    690                 695                 700                 


Asp Leu Phe Leu Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile 
705                 710                 715                 720 


Cys Phe Asn Phe Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu 
                725                 730                 735     


Arg Phe Phe Pro Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg 
            740                 745                 750         


Gln Gly Arg Thr Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu 
        755                 760                 765             


Trp Ala Thr Gly Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser 
    770                 775                 780                 


Phe Ala Val Lys Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr 
785                 790                 795                 800 


Phe Trp Asp Thr Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly 
                805                 810                 815     


Trp Gln Tyr Ile Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg 
            820                 825                 830         


Leu Asp Asn Pro Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu 
        835                 840                 845             


Tyr Ile Arg Gln Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp 
    850                 855                 860                 


Ile His His Pro Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly 
865                 870                 875                 880 


Val Glu Leu Gly Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr 
                885                 890                 895     


Ala Arg Glu Leu Leu Ala Lys Ala Ile Ser Arg Thr Arg Glu Ala Gln 
            900                 905                 910         


Ile Met Ile Gly Ala Ala 
        915             


<210>  103
<211>  881
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  103

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn 
        35                  40                  45              


Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys 
    50                  55                  60                  


Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu 
    130                 135                 140                 


Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln 
145                 150                 155                 160 


Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln 
                165                 170                 175     


Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala 
            180                 185                 190         


Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser 
        195                 200                 205             


Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Gln Leu Phe 
    210                 215                 220                 


Ile Gly Asn Leu Pro His Glu Val Asp Lys Ser Glu Leu Lys Asp Phe 
225                 230                 235                 240 


Phe Gln Ser Tyr Gly Asn Val Val Glu Leu Arg Ile Asn Ser Gly Gly 
                245                 250                 255     


Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro Val 
            260                 265                 270         


Gln Lys Val Leu Ser Asn Arg Pro Ile Met Phe Arg Gly Glu Val Arg 
        275                 280                 285             


Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg 
    290                 295                 300                 


Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly 
305                 310                 315                 320 


Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly 
                325                 330                 335     


Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met 
            340                 345                 350         


Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu 
        355                 360                 365             


Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala Met 
    370                 375                 380                 


Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg Ile 
385                 390                 395                 400 


Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val Phe 
                405                 410                 415     


Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro Gly 
            420                 425                 430         


Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser Gln 
        435                 440                 445             


Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His Asn 
    450                 455                 460                 


Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr Lys 
465                 470                 475                 480 


Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp His 
                485                 490                 495     


Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser Tyr 
            500                 505                 510         


Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys Gly 
        515                 520                 525             


Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp Met 
    530                 535                 540                 


Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro Ile 
545                 550                 555                 560 


Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu Gly 
                565                 570                 575     


Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg Ala 
            580                 585                 590         


Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe Ile 
        595                 600                 605             


Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val Gly 
    610                 615                 620                 


Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile Ser 
625                 630                 635                 640 


Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp Ala 
                645                 650                 655     


Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu Arg 
            660                 665                 670         


Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe Pro 
        675                 680                 685             


Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro Trp 
    690                 695                 700                 


Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr Gly 
705                 710                 715                 720 


Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly Trp 
                725                 730                 735     


Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys Phe 
            740                 745                 750         


Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr Leu 
        755                 760                 765             


Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile Ser 
    770                 775                 780                 


Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro Ala 
785                 790                 795                 800 


Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln Trp 
                805                 810                 815     


Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro Trp 
            820                 825                 830         


Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly Thr 
        835                 840                 845             


Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu Leu 
    850                 855                 860                 


Ala Lys Ala Ile Ser Arg Thr Arg Glu Ala Gln Ile Met Ile Gly Ala 
865                 870                 875                 880 


Ala 
    


<210>  104
<211>  929
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  104

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn 
        35                  40                  45              


Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys 
    50                  55                  60                  


Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu 
    130                 135                 140                 


Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln 
145                 150                 155                 160 


Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln 
                165                 170                 175     


Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala 
            180                 185                 190         


Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser 
        195                 200                 205             


Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro 
    210                 215                 220                 


Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln 
225                 230                 235                 240 


Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser 
                245                 250                 255     


Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro 
            260                 265                 270         


His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro 
        275                 280                 285             


Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg 
    290                 295                 300                 


Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg 
305                 310                 315                 320 


Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His 
                325                 330                 335     


Pro Asp Ser His Glu Lys Lys Thr Arg Ala Ala Arg Glu Gly Asp Arg 
            340                 345                 350         


Arg Asp Asn Arg Leu Arg Gly Pro Gly Gly Pro Arg Gly Gly Leu Gly 
        355                 360                 365             


Gly Gly Met Arg Gly Pro Pro Arg Gly Gly Met Val Gln Lys Pro Gly 
    370                 375                 380                 


Phe Gly Val Gly Arg Gly Leu Ala Pro Arg Gln Lys Leu Ile Pro Met 
385                 390                 395                 400 


Ala Arg Arg Ala Trp Leu Glu His Gly His Ser Cys Phe Leu Cys Glu 
                405                 410                 415     


Ile Val Ile Arg Ser Gln Phe His Thr Thr Tyr Glu Pro Glu Ala Met 
            420                 425                 430         


Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg Ile 
        435                 440                 445             


Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val Phe 
    450                 455                 460                 


Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro Gly 
465                 470                 475                 480 


Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser Gln 
                485                 490                 495     


Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His Asn 
            500                 505                 510         


Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr Lys 
        515                 520                 525             


Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp His 
    530                 535                 540                 


Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser Tyr 
545                 550                 555                 560 


Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys Gly 
                565                 570                 575     


Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp Met 
            580                 585                 590         


Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro Ile 
        595                 600                 605             


Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu Gly 
    610                 615                 620                 


Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg Ala 
625                 630                 635                 640 


Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe Ile 
                645                 650                 655     


Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val Gly 
            660                 665                 670         


Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile Ser 
        675                 680                 685             


Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp Ala 
    690                 695                 700                 


Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu Arg 
705                 710                 715                 720 


Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe Pro 
                725                 730                 735     


Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro Trp 
            740                 745                 750         


Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr Gly 
        755                 760                 765             


Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly Trp 
    770                 775                 780                 


Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys Phe 
785                 790                 795                 800 


Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr Leu 
                805                 810                 815     


Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile Ser 
            820                 825                 830         


Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro Ala 
        835                 840                 845             


Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln Trp 
    850                 855                 860                 


Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro Trp 
865                 870                 875                 880 


Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly Thr 
                885                 890                 895     


Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu Leu 
            900                 905                 910         


Ala Lys Ala Ile Ser Arg Thr Arg Glu Ala Gln Ile Met Ile Gly Ala 
        915                 920                 925             


Ala 
    


<210>  105
<211>  909
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  105

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn 
        35                  40                  45              


Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys 
    50                  55                  60                  


Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu 
    130                 135                 140                 


Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln 
145                 150                 155                 160 


Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln 
                165                 170                 175     


Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala 
            180                 185                 190         


Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser 
        195                 200                 205             


Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro 
    210                 215                 220                 


Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln 
225                 230                 235                 240 


Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser 
                245                 250                 255     


Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro 
            260                 265                 270         


His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro 
        275                 280                 285             


Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg 
    290                 295                 300                 


Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg 
305                 310                 315                 320 


Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His 
                325                 330                 335     


Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp 
            340                 345                 350         


Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu 
        355                 360                 365             


Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val 
    370                 375                 380                 


Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile 
385                 390                 395                 400 


Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Met Lys Met Asp Lys 
                405                 410                 415     


Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg Ile Glu Asp Asn Pro 
            420                 425                 430         


Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val Phe Pro Val Phe Ile 
        435                 440                 445             


Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro Gly Arg Ala Ser Arg 
    450                 455                 460                 


Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser Gln Ser Leu Lys Ala 
465                 470                 475                 480 


Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His Asn Thr Ile Ser Ala 
                485                 490                 495     


Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr Lys Val Val Phe Asn 
            500                 505                 510         


His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp His Thr Val Lys Glu 
        515                 520                 525             


Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser Tyr Asn Gly Asp Leu 
    530                 535                 540                 


Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys Gly Lys Pro Phe Thr 
545                 550                 555                 560 


Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp Met Ser Ile Glu Ser 
                565                 570                 575     


Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro Ile Thr Ala Ala Ala 
            580                 585                 590         


Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu Gly Leu Glu Asn Glu 
        595                 600                 605             


Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg Ala Trp Ser Pro Gly 
    610                 615                 620                 


Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe Ile Glu Lys Gln Leu 
625                 630                 635                 640 


Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val Gly Asn Ser Thr Ser 
                645                 650                 655     


Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile Ser Val Arg His Val 
            660                 665                 670         


Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp Ala Arg Asp Lys Asn 
        675                 680                 685             


Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu Arg Gly Ile Gly Leu 
    690                 695                 700                 


Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe Pro Phe Thr His Glu 
705                 710                 715                 720 


Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro Trp Asp Ala Asp Val 
                725                 730                 735     


Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr Gly Tyr Pro Leu Val 
            740                 745                 750         


Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly Trp Met His Asn Arg 
        755                 760                 765             


Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys Phe Leu Leu Leu Pro 
    770                 775                 780                 


Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr Leu Leu Asp Ala Asp 
785                 790                 795                 800 


Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile Ser Gly Ser Ile Pro 
                805                 810                 815     


Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro Ala Leu Gln Gly Ala 
            820                 825                 830         


Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln Trp Leu Pro Glu Leu 
        835                 840                 845             


Ala Arg Leu Pro Thr Glu Trp Ile His His Pro Trp Asp Ala Pro Leu 
    850                 855                 860                 


Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly Thr Asn Tyr Ala Lys 
865                 870                 875                 880 


Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu Leu Ala Lys Ala Ile 
                885                 890                 895     


Ser Arg Thr Arg Glu Ala Gln Ile Met Ile Gly Ala Ala 
            900                 905                 


<210>  106
<211>  838
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  106

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn 
        35                  40                  45              


Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys 
    50                  55                  60                  


Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu 
    130                 135                 140                 


Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln 
145                 150                 155                 160 


Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln 
                165                 170                 175     


Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala 
            180                 185                 190         


Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser 
        195                 200                 205             


Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro 
    210                 215                 220                 


Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln 
225                 230                 235                 240 


Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser 
                245                 250                 255     


Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro 
            260                 265                 270         


His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro 
        275                 280                 285             


Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg 
    290                 295                 300                 


Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg 
305                 310                 315                 320 


Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His 
                325                 330                 335     


Pro Asp Ser His Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg 
            340                 345                 350         


Arg Asp Leu Arg Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His 
        355                 360                 365             


Glu Gly Ser Val Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly 
    370                 375                 380                 


Gln Phe Tyr Pro Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu 
385                 390                 395                 400 


Ala His Leu Ser Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu 
                405                 410                 415     


Ile Lys Thr His Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val 
            420                 425                 430         


Thr Gly Ala Thr Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser 
        435                 440                 445             


Leu Val Arg Asp His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile 
    450                 455                 460                 


Ser Val Gln Ser Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile 
465                 470                 475                 480 


Tyr Cys Glu Lys Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys 
                485                 490                 495     


Lys Cys Leu Asp Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp 
            500                 505                 510         


Arg Leu Met Pro Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser 
        515                 520                 525             


Ile Glu Glu Leu Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala 
    530                 535                 540                 


Leu Leu Thr Arg Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu 
545                 550                 555                 560 


Leu Asn Glu Phe Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser 
                565                 570                 575     


Lys Lys Val Val Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His 
            580                 585                 590         


Phe Gly Glu Ile Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys 
        595                 600                 605             


Gln Ile Ile Trp Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala 
    610                 615                 620                 


Asp Leu Phe Leu Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile 
625                 630                 635                 640 


Cys Phe Asn Phe Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu 
                645                 650                 655     


Arg Phe Phe Pro Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg 
            660                 665                 670         


Gln Gly Arg Thr Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu 
        675                 680                 685             


Trp Ala Thr Gly Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser 
    690                 695                 700                 


Phe Ala Val Lys Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr 
705                 710                 715                 720 


Phe Trp Asp Thr Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly 
                725                 730                 735     


Trp Gln Tyr Ile Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg 
            740                 745                 750         


Leu Asp Asn Pro Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu 
        755                 760                 765             


Tyr Ile Arg Gln Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp 
    770                 775                 780                 


Ile His His Pro Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly 
785                 790                 795                 800 


Val Glu Leu Gly Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr 
                805                 810                 815     


Ala Arg Glu Leu Leu Ala Lys Ala Ile Ser Arg Thr Arg Glu Ala Gln 
            820                 825                 830         


Ile Met Ile Gly Ala Ala 
        835             


<210>  107
<211>  161
<212>  PRT
<213>  Avena sativa

<400>  107

Gly Glu Phe Leu Ala Thr Thr Leu Glu Arg Ile Glu Lys Asn Phe Val 
1               5                   10                  15      


Ile Thr Asp Pro Arg Leu Pro Asp Asn Pro Ile Ile Phe Ala Ser Asp 
            20                  25                  30          


Ser Phe Leu Gln Leu Thr Glu Tyr Ser Arg Glu Glu Ile Leu Gly Arg 
        35                  40                  45              


Asn Cys Arg Phe Leu Gln Gly Pro Glu Thr Asp Arg Ala Thr Val Arg 
    50                  55                  60                  


Lys Ile Arg Asp Ala Ile Asp Asn Gln Thr Glu Val Thr Val Gln Leu 
65                  70                  75                  80  


Ile Asn Tyr Thr Lys Ser Gly Lys Lys Phe Trp Asn Leu Phe His Leu 
                85                  90                  95      


Gln Pro Met Arg Asp Gln Lys Gly Asp Val Gln Tyr Phe Ile Gly Val 
            100                 105                 110         


Gln Leu Asp Gly Thr Glu His Val Arg Asp Ala Ala Glu Arg Glu Gly 
        115                 120                 125             


Val Met Leu Ile Lys Lys Thr Ala Glu Asn Ile Asp Glu Ala Ala Lys 
    130                 135                 140                 


Glu Leu Pro Asp Ala Asn Leu Arg Pro Glu Asp Leu Trp Ala Asn His 
145                 150                 155                 160 


Gly 
    


<210>  108
<211>  225
<212>  PRT
<213>  Erythrobacter litoralis

<400>  108

Met Leu Asp Met Gly Gln Asp Arg Pro Ile Asp Gly Ser Gly Ala Pro 
1               5                   10                  15      


Gly Ala Asp Asp Thr Arg Val Glu Val Gln Pro Pro Ala Gln Trp Val 
            20                  25                  30          


Leu Asp Leu Ile Glu Ala Ser Pro Ile Ala Ser Val Val Ser Asp Pro 
        35                  40                  45              


Arg Leu Ala Asp Asn Pro Leu Ile Ala Ile Asn Gln Ala Phe Thr Asp 
    50                  55                  60                  


Leu Thr Gly Tyr Ser Glu Glu Glu Cys Val Gly Arg Asn Cys Arg Phe 
65                  70                  75                  80  


Leu Ala Gly Ser Gly Thr Glu Pro Trp Leu Thr Asp Lys Ile Arg Gln 
                85                  90                  95      


Gly Val Arg Glu His Lys Pro Val Leu Val Glu Ile Leu Asn Tyr Lys 
            100                 105                 110         


Lys Asp Gly Thr Pro Phe Arg Asn Ala Val Leu Val Ala Pro Ile Tyr 
        115                 120                 125             


Asp Asp Asp Asp Glu Leu Leu Tyr Phe Leu Gly Ser Gln Val Glu Val 
    130                 135                 140                 


Asp Asp Asp Gln Pro Asn Met Gly Met Ala Arg Arg Glu Arg Ala Ala 
145                 150                 155                 160 


Glu Met Leu Lys Thr Leu Ser Pro Arg Gln Leu Glu Val Thr Thr Leu 
                165                 170                 175     


Val Ala Ser Gly Leu Arg Asn Lys Glu Val Ala Ala Arg Leu Gly Leu 
            180                 185                 190         


Ser Glu Lys Thr Val Lys Met His Arg Gly Leu Val Met Glu Lys Leu 
        195                 200                 205             


Asn Leu Lys Thr Ser Ala Asp Leu Val Arg Ile Ala Val Glu Ala Gly 
    210                 215                 220                 


Ile 
225 


<210>  109
<211>  261
<212>  PRT
<213>  Bacillus subtillis

<400>  109

Met Ala Ser Phe Gln Ser Phe Gly Ile Pro Gly Gln Leu Glu Val Ile 
1               5                   10                  15      


Lys Lys Ala Leu Asp His Val Arg Val Gly Val Val Ile Thr Asp Pro 
            20                  25                  30          


Ala Leu Glu Asp Asn Pro Ile Val Tyr Val Asn Gln Gly Phe Val Gln 
        35                  40                  45              


Met Thr Gly Tyr Glu Thr Glu Glu Ile Leu Gly Lys Asn Cys Arg Phe 
    50                  55                  60                  


Leu Gln Gly Lys His Thr Asp Pro Ala Glu Val Asp Asn Ile Arg Thr 
65                  70                  75                  80  


Ala Leu Gln Asn Lys Glu Pro Val Thr Val Gln Ile Gln Asn Tyr Lys 
                85                  90                  95      


Lys Asp Gly Thr Met Phe Trp Asn Glu Leu Asn Ile Asp Pro Met Glu 
            100                 105                 110         


Ile Glu Asp Lys Thr Tyr Phe Val Gly Ile Gln Asn Asp Ile Thr Lys 
        115                 120                 125             


Gln Lys Glu Tyr Glu Lys Leu Leu Glu Asp Ser Leu Thr Glu Ile Thr 
    130                 135                 140                 


Ala Leu Ser Thr Pro Ile Val Pro Ile Arg Asn Gly Ile Ser Ala Leu 
145                 150                 155                 160 


Pro Leu Val Gly Asn Leu Thr Glu Glu Arg Phe Asn Ser Ile Val Cys 
                165                 170                 175     


Thr Leu Thr Asn Ile Leu Ser Thr Ser Lys Asp Asp Tyr Leu Ile Ile 
            180                 185                 190         


Asp Leu Ser Gly Leu Ala Gln Val Asn Glu Gln Thr Ala Asp Gln Ile 
        195                 200                 205             


Phe Lys Leu Ser His Leu Leu Lys Leu Thr Gly Thr Glu Leu Ile Ile 
    210                 215                 220                 


Thr Gly Ile Lys Pro Glu Leu Ala Met Lys Met Asn Lys Leu Asp Ala 
225                 230                 235                 240 


Asn Phe Ser Ser Leu Lys Thr Tyr Ser Asn Val Lys Asp Ala Val Lys 
                245                 250                 255     


Val Leu Pro Ile Met 
            260     


<210>  110
<211>  176
<212>  PRT
<213>  Rhodobacter sphaeroides

<400>  110

Met Asp Gln Lys Gln Phe Glu Lys Ile Arg Ala Val Phe Asp Arg Ser 
1               5                   10                  15      


Gly Val Ala Leu Thr Leu Val Asp Met Ser Leu Pro Glu Gln Pro Val 
            20                  25                  30          


Val Leu Ala Asn Pro Pro Phe Leu Arg Met Thr Gly Tyr Thr Glu Gly 
        35                  40                  45              


Gln Ile Leu Gly Phe Asn Cys Arg Phe Leu Gln Arg Gly Asp Glu Asn 
    50                  55                  60                  


Ala Gln Ala Arg Ala Asp Ile Arg Asp Ala Leu Lys Leu Gly Arg Glu 
65                  70                  75                  80  


Leu Gln Val Val Leu Arg Asn Tyr Arg Ala Asn Asp Glu Pro Phe Asp 
                85                  90                  95      


Asn Leu Leu Phe Leu His Pro Val Gly Gly Arg Pro Asp Ala Pro Asp 
            100                 105                 110         


Tyr Phe Leu Gly Ser Gln Phe Glu Leu Gly Arg Ser Gly Asn Ser Glu 
        115                 120                 125             


Glu Ala Ala Ala Ala Gly His Ala Gly Ala Leu Thr Gly Glu Leu Ala 
    130                 135                 140                 


Arg Ile Gly Thr Val Ala Ala Arg Leu Glu Met Asp Ser Arg Arg His 
145                 150                 155                 160 


Leu Ala Gln Ala Ala Ala Ala Leu Val Arg Ala Trp Glu Arg Arg Gly 
                165                 170                 175     


