                         SEQUENCE LISTING

<110>  UltraHuman Four Limited
 
<120>  Binding Agents

<130>  P/76795.WO01/MR

<150>  GB 1713298.6
<151>  2017-08-18

<150>  GB 1802595.7
<151>  2018-02-16

<150>  GB 1808570.4
<151>  2018-05-24

<160>  301   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  T or any amino acid (for example, S, N or R)

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  T or a conservative substitution of T

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  N or a conservative substitution of N

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  I or a conservative substitution of I

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  F or any amino acid (for example, V or G)

<400>  1

Gly Tyr Xaa Phe Xaa Xaa Tyr Tyr Xaa Xaa 
1               5                   10  


<210>  2
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  M or a conservative substitution of M

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  I or any amino acid (for example, N, V or D)

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  N or any amino acid (for example, Y)

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  V or any amino acid (for example, G or F)

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  D or a conservative substitution of D

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  G or a conservative substitution of G

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  N or a conservative substitution of N (for example, R)

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Y or a conservative substitution of Y

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  N or a conservative substitution of N (for example, S)

<400>  2

Xaa Gly Xaa Ile Xaa Pro Xaa Xaa Xaa Asp Thr Xaa Xaa Xaa Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Y or any amino acid (for example, H, I, Q or F)

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  T or any amino acid (for example, V or I)

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  M or any amino acid (for example, T, R, P, A or L)

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  D or any amino acid (for example, G)

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  R or any amino acid (for example, Q, N, Y, S, W, K, A, E, F, H, 
       I, L, M, T or V)

<400>  3

Gly Gly Xaa Xaa Xaa Xaa Xaa 
1               5           


<210>  4
<211>  10
<212>  PRT
<213>  Muridae

<400>  4

Gly Tyr Thr Phe Thr Asn Tyr Tyr Val Phe 
1               5                   10  


<210>  5
<211>  7
<212>  PRT
<213>  Muridae

<400>  5

Gly Gly Tyr Thr Met Asp Tyr 
1               5           


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Q or a conservative substitution of Q

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  L or a conservative substitution of L

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  L or a conservative substitution of L

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  N or any amino acid (for example, Q, S, T, A or G) or a 
       conservative substitution of N (for example, Q, S, T or G)

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  G or a conservative substitution of G (for example, A)

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Y or any amino acid (for example, N or S)

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  T or a conservative substitution of T (for example, N)

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  H or any amino acid (for example, D)

<400>  6

Arg Ser Ser Xaa Ser Xaa Xaa His Ser Xaa Xaa Xaa Xaa Tyr Leu Xaa 
1               5                   10                  15      


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  K or any amino acid (for example, L or M)

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  V or any amino acid (for example, G)

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  N or any amino acid (for example, Y)

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  L or any amino acid (for example, F, A or S)

<400>  7

Xaa Xaa Ser Xaa Arg Xaa Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  F or any amino acid (for example, L, M, S, T or V)

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Q or any amino acid (for example, N, A, T or S)

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  T or any amino acid (for example, L, M or I)

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  H or a conservative substitution of H

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  T or any amino acid (for example, V, I, A or F)

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  P or any amino acid (for example, L)

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  R or any amino acid (for example, W)

<400>  8

Xaa Gln Xaa Xaa Xaa Xaa Xaa Xaa Thr 
1               5                   


<210>  9
<211>  16
<212>  PRT
<213>  Muridae

<400>  9

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  10
<211>  7
<212>  PRT
<213>  Muridae

<400>  10

Lys Val Ser Tyr Arg Phe Ser 
1               5           


<210>  11
<211>  9
<212>  PRT
<213>  Muridae

<400>  11

Ser Gln Asn Thr His Val Pro Arg Thr 
1               5                   


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  T or any amino acid (for example, S, N or R)

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  T or a conservative substitution of T

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  N or a conservative substitution of N

<400>  12

Gly Ser Gly Tyr Xaa Phe Xaa Xaa Tyr Tyr 
1               5                   10  


<210>  13
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  N or any amino acid (for example, Y)

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  V or any amino acid (for example, G or F)

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  D or a conservative substitution of D

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  G or a conservative substitution of G

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  N or a conservative substitution of N (for example, R)

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Y or a conservative substitution of Y

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  N or a conservative substitution of N (for example, S)

<400>  13

Ile Xaa Pro Xaa Xaa Xaa Asp Thr Xaa Xaa Xaa Pro Ser Phe Gln Gly 
1               5                   10                  15      


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Y or any amino acid (for example, H, I, Q or F)

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  T or any amino acid (for example, V or I)

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  M or any amino acid (for example, T, R, P, A or L)

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  D or any amino acid (for example, G)

<400>  14

Gly Gly Xaa Xaa Xaa Xaa 
1               5       


<210>  15
<211>  10
<212>  PRT
<213>  Muridae

<400>  15

Gly Ser Gly Tyr Thr Phe Thr Asn Tyr Tyr 
1               5                   10  


<210>  16
<211>  6
<212>  PRT
<213>  Muridae

<400>  16

Gly Gly Tyr Thr Met Asp 
1               5       


<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Q or a conservative substitution of Q

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  L or a conservative substitution of L

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  L or a conservative substitution of L

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  N or any amino acid (for example, Q, S, T, A or G) or a 
       conservative substitution of N (for example, Q, S, T or G)

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  G or a conservative substitution of G (for example, A)

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Y or any amino acid (for example, N or S)

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  T or a conservative substitution of T (for example, N)

<400>  17

Ser Ser Xaa Ser Xaa Xaa His Ser Xaa Xaa Xaa Xaa Tyr 
1               5                   10              


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Q or any amino acid (for example, N, A, T or S)

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  T or any amino acid (for example, L, M or I)

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  H or a conservative substitution of H

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  T or any amino acid (for example, V, I, A or F)

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  P or any amino acid (for example, L)

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  R or any amino acid (for example, W)

<400>  18

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  19
<211>  13
<212>  PRT
<213>  Muridae

<400>  19

Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10              


<210>  20
<211>  6
<212>  PRT
<213>  Muridae

<400>  20

Asn Thr His Val Pro Arg 
1               5       


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  T/S/N/R

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  T/N

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  N/S

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  I/V

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  F/V/G

<400>  21

Gly Tyr Xaa Phe Xaa Xaa Tyr Tyr Xaa Xaa 
1               5                   10  


<210>  22
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  M/I

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  V/N/I/D

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  N/Y

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  V/G/F

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  N/D

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  G/S

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  N/R/K

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  F/Y

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  N/S

<400>  22

Xaa Gly Xaa Ile Xaa Pro Xaa Xaa Xaa Asp Thr Xaa Xaa Xaa Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  F/H/I/Q/Y

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  T/V/I

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  M/T/R/P/A/L

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  D/G

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Y/Q/N/R/S/W/K/A/E/F/H/I/L/M/T/V

<400>  23

Gly Gly Xaa Xaa Xaa Xaa Xaa 
1               5           


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  T/S/N/R

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  T/N

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  N/S

<400>  24

Gly Ser Gly Tyr Xaa Phe Xaa Xaa Tyr Tyr 
1               5                   10  


<210>  25
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  N/Y

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  V/G/F

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  N/D

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  G/S

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  N/R/K

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  F/Y

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  N/S

<400>  25

Ile Xaa Pro Xaa Xaa Xaa Asp Thr Xaa Xaa Xaa Pro Ser Phe Gln Gly 
1               5                   10                  15      


<210>  26
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  F/H/I/Q/Y

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  T/V/I

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  M/T/R/P/A/L

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  D/G

<400>  26

Gly Gly Xaa Xaa Xaa Xaa 
1               5       


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  T/S

<400>  27

Gly Tyr Xaa Phe Thr Asn Tyr Tyr Ile Phe 
1               5                   10  


<210>  28
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  M/I

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  I/D

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  N/D

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  N/R

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  F/Y

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  N/S

<400>  28

Xaa Gly Xaa Ile Asn Pro Val Xaa Gly Asp Thr Xaa Xaa Xaa Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  F/Y

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  M/P

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Y/R/K/I

<400>  29

Gly Gly Xaa Thr Xaa Asp Xaa 
1               5           


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  T/S

<400>  30

Gly Ser Gly Tyr Xaa Phe Thr Asn Tyr Tyr 
1               5                   10  


<210>  31
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  N/D

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  N/R

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  F/Y

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  N/S

<400>  31

Ile Asn Pro Val Xaa Gly Asp Thr Xaa Xaa Xaa Pro Ser Phe Gln Gly 
1               5                   10                  15      


<210>  32
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  F/Y

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  M/P

<400>  32

Gly Gly Xaa Thr Xaa Asp 
1               5       


<210>  33
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Q/H

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  F/L

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  L/V

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  N/Q/A

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  G/A

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Y/N/S

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  N/T

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  H/D

<400>  33

Arg Ser Ser Xaa Ser Xaa Xaa His Ser Xaa Xaa Xaa Xaa Tyr Leu Xaa 
1               5                   10                  15      


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  L/K/M

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  V/G

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  N/Y

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  A/F/L/S

<400>  34

Xaa Xaa Ser Xaa Arg Xaa Ser 
1               5           


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  F/L/M/S/T/V

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Q/N/A/T/S

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  T/L/M/I

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Q/H

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  T/V/I/A/F

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  P/L

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  R/W

<400>  35

Xaa Gln Xaa Xaa Xaa Xaa Xaa Xaa Thr 
1               5                   


<210>  36
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Q/H

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  F/L

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  L/V

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  N/Q/A

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  G/A

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Y/N/S

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  N/T

<400>  36

Ser Ser Xaa Ser Xaa Xaa His Ser Xaa Xaa Xaa Xaa Tyr 
1               5                   10              


<210>  37
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Q/N/A/T/S

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  T/L/M/I

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Q/H

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  T/V/I/A/F

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  P/L

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  R/W

<400>  37

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  38
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  L/V

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  N/Q/A

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Y/N

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  N/T

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  H/D

<400>  38

Arg Ser Ser Gln Ser Leu Xaa His Ser Xaa Gly Xaa Xaa Tyr Leu Xaa 
1               5                   10                  15      


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  L/K

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  V/G

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  N/Y

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  A/F/L

<400>  39

Xaa Xaa Ser Xaa Arg Xaa Ser 
1               5           


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  F/S

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Q/N/A

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  T/L

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Q/H

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  T/V

<400>  40

Xaa Gln Xaa Xaa Xaa Xaa Pro Arg Thr 
1               5                   


<210>  41
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  L/V

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  N/Q/A

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Y/N

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  N/T

<400>  41

Ser Ser Gln Ser Leu Xaa His Ser Xaa Gly Xaa Xaa Tyr 
1               5                   10              


<210>  42
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Q/N/A

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  T/L

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Q/H

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  T/V

<400>  42

Xaa Xaa Xaa Xaa Pro Arg 
1               5       


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  43

Gly Tyr Ser Phe Thr Asn Tyr Tyr Ile Phe 
1               5                   10  


<210>  44
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  44

Met Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Tyr Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  45

Gly Gly Tyr Thr Pro Asp Tyr 
1               5           


<210>  46
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  46

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu His 
1               5                   10                  15      


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  47

Lys Gly Ser Asn Arg Phe Ser 
1               5           


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  48

Ser Gln Asn Leu His Val Pro Arg Thr 
1               5                   


<210>  49
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  49

Gly Tyr Thr Phe Thr Asn Tyr Tyr Ile Phe 
1               5                   10  


<210>  50
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  50

Met Gly Ile Ile Asn Pro Val Asp Gly Asp Thr Asn Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  51

Gly Gly Tyr Thr Met Asp Arg 
1               5           


<210>  52
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  52

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Thr Tyr Leu His 
1               5                   10                  15      


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  53

Lys Val Ser Asn Arg Leu Ser 
1               5           


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  54

Phe Gln Asn Thr His Thr Pro Arg Thr 
1               5                   


<210>  55
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  55

Ile Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  56

Gly Gly Tyr Thr Met Asp Lys 
1               5           


<210>  57
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  57

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Tyr Thr Tyr Leu His 
1               5                   10                  15      


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  58

Lys Gly Ser Tyr Arg Ala Ser 
1               5           


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  59

Ser Gln Asn Thr Gln Thr Pro Arg Thr 
1               5                   


<210>  60
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  60

Met Gly Ile Ile Asn Pro Val Asn Gly Asp Thr Asn Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  61

Gly Gly Tyr Thr Met Gly Lys 
1               5           


<210>  62
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  62

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu Asp 
1               5                   10                  15      


<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  63

Lys Gly Ser Tyr Arg Phe Ser 
1               5           


<210>  64
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  64

Ser Gln Ala Thr His Thr Pro Arg Thr 
1               5                   


<210>  65
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  65

Met Gly Ile Ile Asn Pro Val Asp Gly Asp Thr Arg Tyr Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  66
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  66

Gly Gly Phe Thr Met Asp Tyr 
1               5           


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  67

Lys Gly Ser Asn Arg Ala Ser 
1               5           


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  68

Ser Gln Asn Thr His Thr Pro Arg Thr 
1               5                   


<210>  69
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  69

Ile Gly Ile Ile Asn Pro Val Asp Gly Asp Thr Arg Tyr Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  70
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  70

Gly Gly Tyr Thr Met Asp Ile 
1               5           


<210>  71
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  71

Leu Gly Ser Asn Arg Phe Ser 
1               5           


<210>  72
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  72

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  73
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  73

Ser Gln Ala Thr Gln Thr Pro Arg Thr 
1               5                   


<210>  74
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  74

Met Gly Ile Ile Asn Pro Val Asp Gly Asp Thr Arg Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  75

Lys Gly Ser Asn Arg Leu Ser 
1               5           


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  76

Phe Gln Asn Thr Gln Thr Pro Arg Thr 
1               5                   


<210>  77
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  77

Leu Gly Ser Asn Arg Leu Ser 
1               5           


<210>  78
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  78

Arg Ser Ser Gln Ser Leu Leu His Ser Gln Gly Tyr Thr Tyr Leu His 
1               5                   10                  15      


<210>  79
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  79

Phe Gln Gln Thr His Thr Pro Arg Thr 
1               5                   


<210>  80
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  80

Arg Ser Ser Gln Ser Leu Leu His Ser Ser Gly Tyr Asn Tyr Leu His 
1               5                   10                  15      


<210>  81
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  81

Arg Ser Ser Gln Ser Leu Leu His Ser Gly Gly Tyr Asn Tyr Leu His 
1               5                   10                  15      


<210>  82
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  82

Arg Ser Ser Gln Ser Leu Leu His Ser Ala Gly Tyr Asn Tyr Leu His 
1               5                   10                  15      


<210>  83
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  83

Arg Ser Ser Gln Ser Leu Leu His Ser Thr Gly Tyr Asn Tyr Leu His 
1               5                   10                  15      


<210>  84
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  84

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Ala Tyr Asn Tyr Leu His 
1               5                   10                  15      


<210>  85
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  85

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  86
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  86

Gly Ser Gly Tyr Ser Phe Thr Asn Tyr Tyr 
1               5                   10  


<210>  87
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  87

Ile Asn Pro Val Asn Gly Asp Thr Asn Tyr Ser Pro Ser Phe Gln Gly 
1               5                   10                  15      


<210>  88
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  88

Gly Gly Tyr Thr Pro Asp 
1               5       


<210>  89
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  89

Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10              


<210>  90
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  90

Asn Leu His Val Pro Arg 
1               5       


<210>  91
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  91

Ile Asn Pro Val Asp Gly Asp Thr Asn Tyr Asn Pro Ser Phe Gln Gly 
1               5                   10                  15      


<210>  92
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  92

Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Thr Tyr 
1               5                   10              


<210>  93
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  93

Asn Thr His Thr Pro Arg 
1               5       


<210>  94
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  94

Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Ser Pro Ser Phe Gln Gly 
1               5                   10                  15      


<210>  95
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  95

Ser Ser Gln Ser Leu Val His Ser Asn Gly Tyr Thr Tyr 
1               5                   10              


<210>  96
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  96

Asn Thr Gln Thr Pro Arg 
1               5       


<210>  97
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  97

Ile Asn Pro Val Asn Gly Asp Thr Asn Tyr Asn Pro Ser Phe Gln Gly 
1               5                   10                  15      


<210>  98
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  98

Gly Gly Tyr Thr Met Gly 
1               5       


<210>  99
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  99

Ala Thr His Thr Pro Arg 
1               5       


<210>  100
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  100

Ile Asn Pro Val Asp Gly Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly 
1               5                   10                  15      


<210>  101
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  101

Gly Gly Phe Thr Met Asp 
1               5       


<210>  102
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  102

Ala Thr Gln Thr Pro Arg 
1               5       


<210>  103
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  103

Ile Asn Pro Val Asp Gly Asp Thr Arg Tyr Asn Pro Ser Phe Gln Gly 
1               5                   10                  15      


<210>  104
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  104

Ser Ser Gln Ser Leu Leu His Ser Gln Gly Tyr Thr Tyr 
1               5                   10              


<210>  105
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  105

Gln Thr His Thr Pro Arg 
1               5       


<210>  106
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  106

Ser Ser Gln Ser Leu Leu His Ser Ser Gly Tyr Asn Tyr 
1               5                   10              


<210>  107
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  107

Ser Ser Gln Ser Leu Leu His Ser Gly Gly Tyr Asn Tyr 
1               5                   10              


<210>  108
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  108

Ser Ser Gln Ser Leu Leu His Ser Ala Gly Tyr Asn Tyr 
1               5                   10              


<210>  109
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  109

Ser Ser Gln Ser Leu Leu His Ser Thr Gly Tyr Asn Tyr 
1               5                   10              


<210>  110
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  110

Ser Ser Gln Ser Leu Leu His Ser Asn Ala Tyr Asn Tyr 
1               5                   10              


<210>  111
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  N/R

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  N/S

<400>  111

Met Gly Ile Ile Asn Pro Val Asp Gly Asp Thr Xaa Tyr Xaa Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  112
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  N/A

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  N/T

<400>  112

Arg Ser Ser Gln Ser Leu Leu His Ser Xaa Gly Tyr Xaa Tyr Leu His 
1               5                   10                  15      


<210>  113
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  L/F

<400>  113

Lys Val Ser Asn Arg Xaa Ser 
1               5           


<210>  114
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  N/R

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  N/S

<400>  114

Ile Asn Pro Val Asp Gly Asp Thr Xaa Tyr Xaa Pro Ser Phe Gln Gly 
1               5                   10                  15      


<210>  115
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR


<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  N/A

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  N/T

<400>  115

Ser Ser Gln Ser Leu Leu His Ser Xaa Gly Tyr Xaa Tyr 
1               5                   10              


<210>  116
<211>  9
<212>  PRT
<213>  Muridae

<400>  116

Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   


<210>  117
<211>  9
<212>  PRT
<213>  Muridae

<400>  117

Leu Leu Ile Tyr Lys Val Ser Tyr Arg 
1               5                   


<210>  118
<211>  9
<212>  PRT
<213>  Muridae

<400>  118

Tyr Arg Phe Ser Gly Val Pro Asp Arg 
1               5                   


<210>  119
<211>  9
<212>  PRT
<213>  Muridae

<400>  119

Leu Ile Tyr Lys Val Ser Tyr Arg Phe 
1               5                   


<210>  120
<211>  16
<212>  PRT
<213>  Muridae

<400>  120

Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro Asp Arg 
1               5                   10                  15      


<210>  121
<211>  9
<212>  PRT
<213>  Muridae

<400>  121

Val Gly Val Tyr Tyr Cys Phe Gln Asn 
1               5                   


<210>  122
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  122

Ala Gly Val Tyr Tyr Cys Phe Gln Asn Thr His Thr Pro Arg Thr 
1               5                   10                  15  


<210>  123
<211>  19
<212>  PRT
<213>  Muridae

<400>  123

Ile Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys 
1               5                   10                  15      


Phe Lys Asn 
            


<210>  124
<211>  5
<212>  PRT
<213>  Muridae

<400>  124

Asn Tyr Tyr Val Phe 
1               5   


<210>  125
<211>  17
<212>  PRT
<213>  Muridae

<400>  125

Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  126
<211>  7
<212>  PRT
<213>  Muridae

<400>  126

Gly Tyr Thr Phe Thr Asn Tyr 
1               5           


<210>  127
<211>  6
<212>  PRT
<213>  Muridae

<400>  127

Asn Pro Val Asn Gly Asp 
1               5       


<210>  128
<211>  8
<212>  PRT
<213>  Muridae

<400>  128

Gly Tyr Thr Phe Thr Asn Tyr Tyr 
1               5               


<210>  129
<211>  8
<212>  PRT
<213>  Muridae

<400>  129

Ile Asn Pro Val Asn Gly Asp Thr 
1               5               


<210>  130
<211>  9
<212>  PRT
<213>  Muridae

<400>  130

Thr Arg Gly Gly Tyr Thr Met Asp Tyr 
1               5                   


<210>  131
<211>  11
<212>  PRT
<213>  Muridae

<400>  131

Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  132
<211>  16
<212>  PRT
<213>  Muridae

<400>  132

Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe Lys Asn 
1               5                   10                  15      


<210>  133
<211>  10
<212>  PRT
<213>  Muridae

<400>  133

Asp Ile Asn Pro Val Asn Gly Asp Thr Asn 
1               5                   10  


<210>  134
<211>  6
<212>  PRT
<213>  Muridae

<400>  134

Thr Asn Tyr Tyr Val Phe 
1               5       


<210>  135
<211>  12
<212>  PRT
<213>  Muridae

<400>  135

Ile Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn 
1               5                   10          


<210>  136
<211>  8
<212>  PRT
<213>  Muridae

<400>  136

Thr Arg Gly Gly Tyr Thr Met Asp 
1               5               


<210>  137
<211>  11
<212>  PRT
<213>  Muridae

<400>  137

His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr 
1               5                   10      


<210>  138
<211>  10
<212>  PRT
<213>  Muridae

<400>  138

Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe 
1               5                   10  


<210>  139
<211>  8
<212>  PRT
<213>  Muridae

<400>  139

Ser Gln Asn Thr His Val Pro Arg 
1               5               


<210>  140
<211>  116
<212>  PRT
<213>  Muridae


<220>
<221>  DOMAIN
<222>  (1)..(116)
<223>  VH DOMAIN

<400>  140

Glu Val Gln Leu Gln Gln Phe Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Thr Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  141
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH DOMAIN

<400>  141

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  142
<211>  112
<212>  PRT
<213>  Muridae


<220>
<221>  DOMAIN
<222>  (1)..(112)
<223>  VL DOMAIN

<400>  142

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  143
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL DOMAIN

<400>  143

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  144
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  144

Arg Ser Ser His Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  145
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  145

Gly Tyr Asn Phe Thr Asn Tyr Tyr Ile Phe 
1               5                   10  


<210>  146
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  146

Met Gly Asp Ile Asn Pro Phe Asn Gly Asp Thr Asn Phe Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  147
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  147

Arg Ser Ser Gln Ser Phe Leu His Ser Asn Gly Asn Asn Tyr Leu His 
1               5                   10                  15      


<210>  148
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  148

Leu Gln Asn Thr His Thr Pro Arg Thr 
1               5                   


<210>  149
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  149

Gly Tyr Arg Phe Thr Asn Tyr Tyr Ile Phe 
1               5                   10  


<210>  150
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  150

Met Gly Asp Ile Asn Pro Gly Asp Gly Asp Thr Asn Phe Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  151
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  151

Gly Gly His Thr Met Asp Tyr 
1               5           


<210>  152
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  152

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Asn Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  153
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  153

Lys Gly Ser Asn Arg Ser Ser 
1               5           


<210>  154
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  154

Met Gln Ala Leu His Thr Pro Trp Thr 
1               5                   


<210>  155
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  155

Gly Tyr Arg Phe Thr Asn Tyr Tyr Val Phe 
1               5                   10  


<210>  156
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  156

Met Gly Asp Ile Asn Pro Gly Asn Gly Asp Thr Asn Phe Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  157
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  157

Gly Gly Ile Thr Met Asp Tyr 
1               5           


<210>  158
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  158

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Asn Asn Tyr Leu His 
1               5                   10                  15      


<210>  159
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  159

Met Gln Ala Leu His Val Pro Arg Thr 
1               5                   


<210>  160
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  160

Gly Tyr Ser Phe Asn Asn Tyr Tyr Ile Phe 
1               5                   10  


<210>  161
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  161

Met Gly Asp Ile Asn Pro Gly Asn Gly Asp Thr Asn Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  162
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  162

Gly Gly Gln Thr Met Asp Gln 
1               5           


<210>  163
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  163

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Asp 
1               5                   10                  15      


<210>  164
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  164

Met Gln Ala Leu Gln Val Pro Trp Thr 
1               5                   


<210>  165
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  165

Met Gly Asp Ile Asn Pro Gly Asn Gly Asp Thr Asn Tyr Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  166
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  166

Gly Gly Tyr Ile Met Asp Tyr 
1               5           


<210>  167
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  167

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  168
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  168

Lys Gly Ser Tyr Arg Leu Ser 
1               5           


<210>  169
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  169

Met Gln Ala Thr His Val Pro Trp Thr 
1               5                   


<210>  170
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  170

Gly Tyr Ser Phe Thr Ser Tyr Tyr Ile Phe 
1               5                   10  


<210>  171
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  171

Met Gly Asp Ile Asn Pro Gly Asn Gly Asp Thr Arg Phe Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  172
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  172

Gly Gly Tyr Thr Ala Asp Tyr 
1               5           


<210>  173
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  173

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Ser Asn Tyr Leu His 
1               5                   10                  15      


<210>  174
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  174

Lys Val Ser Asn Arg Ala Ser 
1               5           


<210>  175
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  175

Met Gln Ala Thr Gln Val Pro Trp Thr 
1               5                   


<210>  176
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  176

Gly Tyr Ser Phe Thr Ser Tyr Tyr Ile Val 
1               5                   10  


<210>  177
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  177

Met Gly Asp Ile Asn Pro Gly Asn Gly Asp Thr Arg Phe Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  178
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  178

Gly Gly Tyr Thr Leu Asp Tyr 
1               5           


<210>  179
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  179

Met Gln Asn Leu Gln Thr Pro Arg Thr 
1               5                   


<210>  180
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  180

Gly Tyr Ser Phe Thr Ser Tyr Tyr Val Phe 
1               5                   10  


<210>  181
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  181

Met Gly Asp Ile Asn Pro Gly Asn Gly Asp Thr Arg Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  182
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  182

Gly Gly Tyr Thr Met Asp Ala 
1               5           


<210>  183
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  183

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Thr Tyr Leu Asp 
1               5                   10                  15      


<210>  184
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  184

Met Gln Asn Thr His Ile Pro Arg Thr 
1               5                   


<210>  185
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  185

Gly Tyr Ser Phe Thr Ser Tyr Tyr Val Gly 
1               5                   10  


<210>  186
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  186

Met Gly Asp Ile Asn Pro Gly Asn Gly Asp Thr Arg Tyr Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  187
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  187

Gly Gly Tyr Thr Met Asp Glu 
1               5           


<210>  188
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  188

Lys Val Ser Tyr Arg Ala Ser 
1               5           


<210>  189
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  189

Met Gln Asn Thr His Thr Leu Arg Thr 
1               5                   


<210>  190
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  190

Met Gly Asp Ile Asn Pro Gly Asn Ser Asp Thr Asn Phe Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  191
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  191

Gly Gly Tyr Thr Met Asp Phe 
1               5           


<210>  192
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  192

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  193
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  193

Lys Val Ser Tyr Arg Leu Ser 
1               5           


<210>  194
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  194

Met Gln Asn Thr His Thr Pro Arg Thr 
1               5                   


<210>  195
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  195

Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile Phe 
1               5                   10  


<210>  196
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  196

Met Gly Asp Ile Asn Pro Gly Asn Ser Asp Thr Asn Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  197
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  197

Gly Gly Tyr Thr Met Asp His 
1               5           


<210>  198
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  198

Met Gln Asn Thr His Val Pro Arg Thr 
1               5                   


<210>  199
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  199

Gly Tyr Thr Phe Thr Ser Tyr Tyr Val Phe 
1               5                   10  


<210>  200
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  200

Met Gly Asp Ile Asn Pro Val Asp Gly Asp Thr Lys Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  201
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  201

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Asn Tyr Leu His 
1               5                   10                  15      


<210>  202
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  202

Met Gln Asn Thr Gln Thr Pro Arg Thr 
1               5                   


<210>  203
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  203

Met Gly Asp Ile Asn Pro Val Asp Gly Asp Thr Asn Phe Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  204
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  204

Met Gln Thr Thr His Thr Pro Arg Thr 
1               5                   


<210>  205
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  205

Met Gly Asp Ile Asn Pro Val Asp Gly Asp Thr Asn Phe Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  206
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  206

Gly Gly Tyr Thr Met Asp Leu 
1               5           


<210>  207
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  207

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Tyr Asn Tyr Leu His 
1               5                   10                  15      


<210>  208
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  208

Leu Gly Ser Tyr Arg Ala Ser 
1               5           


<210>  209
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  209

Met Gln Thr Thr Gln Ile Pro Arg Thr 
1               5                   


<210>  210
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  210

Met Gly Asp Ile Asn Pro Val Asp Gly Asp Thr Asn Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  211
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  211

Gly Gly Tyr Thr Met Asp Met 
1               5           


<210>  212
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  212

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Tyr Thr Tyr Leu Asp 
1               5                   10                  15      


<210>  213
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  213

Leu Gly Ser Tyr Arg Phe Ser 
1               5           


<210>  214
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  214

Ser Gln Ala Thr His Phe Pro Arg Thr 
1               5                   


<210>  215
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  215

Met Gly Asp Ile Asn Pro Val Asp Gly Asp Thr Asn Tyr Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  216
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  216

Gly Gly Tyr Thr Met Asp Asn 
1               5           


<210>  217
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  217

Leu Gly Ser Tyr Arg Leu Ser 
1               5           


<210>  218
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  218

Met Gly Asp Ile Asn Pro Val Asp Gly Asp Thr Arg Phe Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  219
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  219

Gly Gly Tyr Thr Met Asp Gln 
1               5           


<210>  220
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  220

Leu Val Ser Asn Arg Ala Ser 
1               5           


<210>  221
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  221

Ser Gln Asn Ile Gln Thr Pro Arg Thr 
1               5                   


<210>  222
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  222

Met Gly Asp Ile Asn Pro Val Asp Gly Asp Thr Arg Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  223
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  223

Leu Val Ser Asn Arg Phe Ser 
1               5           


<210>  224
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  224

Ser Gln Asn Leu His Thr Pro Arg Thr 
1               5                   


<210>  225
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  225

Met Gly Asp Ile Asn Pro Val Asp Gly Asp Thr Arg Tyr Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  226
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  226

Gly Gly Tyr Thr Met Asp Thr 
1               5           


<210>  227
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  227

Leu Val Ser Asn Arg Leu Ser 
1               5           


<210>  228
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  228

Ser Gln Asn Leu Gln Thr Pro Arg Thr 
1               5                   


<210>  229
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  229

Met Gly Asp Ile Asn Pro Val Asp Ser Asp Thr Lys Phe Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  230
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  230

Gly Gly Tyr Thr Met Asp Val 
1               5           


<210>  231
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  231

Leu Val Ser Tyr Arg Ala Ser 
1               5           


<210>  232
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  232

Ser Gln Asn Met His Thr Pro Arg Thr 
1               5                   


<210>  233
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  233

Met Gly Asp Ile Asn Pro Val Asp Ser Asp Thr Asn Phe Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  234
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  234

Gly Gly Tyr Thr Met Asp Trp 
1               5           


<210>  235
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  235

Met Gly Ser Asn Arg Phe Ser 
1               5           


<210>  236
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  236

Ser Gln Asn Thr His Phe Pro Arg Thr 
1               5                   


<210>  237
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  237

Met Gly Asp Ile Asn Pro Val Asp Ser Asp Thr Asn Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  238
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  238

Met Gly Ser Tyr Arg Leu Ser 
1               5           


<210>  239
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  239

Ser Gln Asn Thr His Val Pro Trp Thr 
1               5                   


<210>  240
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  240

Met Gly Asp Ile Asn Pro Val Asp Ser Asp Thr Asn Tyr Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  241
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  241

Met Val Ser Asn Arg Phe Ser 
1               5           


<210>  242
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  242

Ser Gln Asn Thr Gln Ala Pro Arg Thr 
1               5                   


<210>  243
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  243

Met Gly Asp Ile Asn Pro Val Asp Ser Asp Thr Arg Phe Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  244
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  244

Gly Gly Tyr Thr Arg Asp Tyr 
1               5           


<210>  245
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  245

Met Gly Asp Ile Asn Pro Val Asp Ser Asp Thr Arg Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  246
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  246

Gly Gly Tyr Thr Thr Asp Ser 
1               5           


<210>  247
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  247

Ser Gln Asn Thr Gln Thr Pro Trp Thr 
1               5                   


<210>  248
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  248

Met Gly Asp Ile Asn Pro Val Asp Ser Asp Thr Arg Tyr Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  249
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  249

Gly Gly Tyr Thr Thr Asp Trp 
1               5           


<210>  250
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  250

Ser Gln Asn Thr Gln Val Pro Arg Thr 
1               5                   


<210>  251
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  251

Met Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Lys Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  252
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  252

Gly Gly Tyr Thr Thr Asp Tyr 
1               5           


<210>  253
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  253

Ser Gln Ser Thr His Val Pro Arg Thr 
1               5                   


<210>  254
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  254

Met Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  255
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  255

Gly Gly Tyr Val Met Asp Tyr 
1               5           


<210>  256
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  256

Ser Gln Thr Thr His Ile Pro Arg Thr 
1               5                   


<210>  257
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  257

Met Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  258
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  258

Ser Gln Thr Thr His Val Pro Arg Thr 
1               5                   


<210>  259
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  259

Ser Gln Thr Thr Gln Thr Pro Arg Thr 
1               5                   


<210>  260
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  260

Met Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Arg Phe Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  261
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  261

Thr Gln Asn Thr His Thr Pro Arg Thr 
1               5                   


<210>  262
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  262

Met Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Arg Phe Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  263
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  263

Val Gln Asn Thr Gln Val Pro Arg Thr 
1               5                   


<210>  264
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  264

Met Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Arg Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  265
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  265

Met Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Arg Tyr Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  266
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  266

Met Gly Asp Ile Asn Pro Val Asn Ser Asp Thr Lys Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  267
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  267

Met Gly Asp Ile Asn Pro Val Asn Ser Asp Thr Asn Phe Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  268
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  268

Met Gly Asp Ile Asn Pro Val Asn Ser Asp Thr Asn Tyr Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  269
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  269

Met Gly Asp Ile Asn Pro Val Asn Ser Asp Thr Arg Phe Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  270
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  270

Met Gly Asp Ile Asn Pro Val Asn Ser Asp Thr Arg Phe Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  271
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  271

Met Gly Asp Ile Asn Pro Val Asn Ser Asp Thr Arg Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  272
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  272

Met Gly Asp Ile Asn Pro Val Asn Ser Asp Thr Arg Tyr Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  273
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  273

Met Gly Asp Ile Tyr Pro Gly Asn Ser Asp Thr Lys Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  274
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  274

Met Gly Asp Ile Tyr Pro Val Asn Gly Asp Thr Arg Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  275
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  275

Met Gly Ile Ile Asn Pro Gly Asn Gly Asp Thr Arg Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  276
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  276

Met Gly Ile Ile Asn Pro Val Asp Gly Asp Thr Lys Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  277
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  277

Met Gly Ile Ile Asn Pro Val Asp Gly Asp Thr Asn Tyr Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  278
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  278

Met Gly Ile Ile Asn Pro Val Asp Gly Asp Thr Arg Phe Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  279
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  279

Met Gly Ile Ile Asn Pro Val Asp Gly Asp Thr Arg Phe Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  280
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  280

Met Gly Ile Ile Asn Pro Val Asp Ser Asp Thr Asn Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  281
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  281

Met Gly Ile Ile Asn Pro Val Asp Ser Asp Thr Arg Phe Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  282
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  282

Met Gly Ile Ile Asn Pro Val Asp Ser Asp Thr Arg Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  283
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  283

Met Gly Ile Ile Asn Pro Val Asp Ser Asp Thr Arg Tyr Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  284
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  284

Met Gly Ile Ile Asn Pro Val Asn Gly Asp Thr Lys Phe Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  285
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  285

Met Gly Ile Ile Asn Pro Val Asn Gly Asp Thr Lys Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  286
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  286

Met Gly Ile Ile Asn Pro Val Asn Gly Asp Thr Lys Tyr Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  287
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  287

Met Gly Ile Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  288
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  288

Met Gly Ile Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  289
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  289

Met Gly Ile Ile Asn Pro Val Asn Gly Asp Thr Asn Tyr Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  290
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  290

Met Gly Ile Ile Asn Pro Val Asn Gly Asp Thr Arg Phe Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  291
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  291

Met Gly Ile Ile Asn Pro Val Asn Gly Asp Thr Arg Phe Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  292
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  292

Met Gly Ile Ile Asn Pro Val Asn Gly Asp Thr Arg Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  293
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  293

Met Gly Ile Ile Asn Pro Val Asn Gly Asp Thr Arg Tyr Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  294
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  294

Met Gly Ile Ile Asn Pro Val Asn Ser Asp Thr Lys Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  295
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  295

Met Gly Ile Ile Asn Pro Val Asn Ser Asp Thr Asn Phe Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  296
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  296

Met Gly Ile Ile Asn Pro Val Asn Ser Asp Thr Asn Tyr Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  297
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  297

Met Gly Ile Ile Asn Pro Val Asn Ser Asp Thr Arg Phe Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  298
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  298

Met Gly Ile Ile Asn Pro Val Asn Ser Asp Thr Arg Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  299
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  299

Met Gly Ile Ile Asn Pro Val Asn Ser Asp Thr Arg Tyr Ser Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  300
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  300

Met Gly Asn Ile Asn Pro Val Asp Gly Asp Thr Arg Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  301
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified CDR

<400>  301

Met Gly Val Ile Asn Pro Val Asn Ser Asp Thr Asn Tyr Asn Pro Ser 
1               5                   10                  15      


Phe Gln Gly 
            


