                         SEQUENCE LISTING

<110>  Universite du Luxembourg
 
<120>  MYO5B as novel biomarker for cancer

<130>  LUX16106PCT

<150>  LU 100371
<151>  2017-08-14

<150>  EP 17186112.3
<151>  2017-08-14

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide primer

<400>  1
aacgtgggca tggagaacaa gg                                                22


<210>  2
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide primer

<400>  2
ttcttcagcc gctctacctc ca                                                22


<210>  3
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide primer

<400>  3
tcaggaacgg tttcggacga tc                                                22


<210>  4
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide primer

<400>  4
gctcctcaat gttgcgaatc cag                                               23


<210>  5
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide primer

<400>  5
actgctcttc ctggagacct ca                                                22


<210>  6
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide primer

<400>  6
gctgttctgt ctctgcttgg ac                                                22


<210>  7
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide primer

<400>  7
tggacaggac tgaacgtctt                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide primer

<400>  8
gagcacacag agggctacaa                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide primer

<400>  9
cagacaaggt cccaaagaca                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide primer

<400>  10
ccattatggc gtgtgaagtc                                                   20


<210>  11
<211>  5547
<212>  DNA
<213>  Homo sapiens

<400>  11
atgtcggtgg gcgagctcta cagccagtgc acaagggtct ggatccctga ccctgatgag       60

gtatggcgct cagctgagtt aaccaaggac tacaaagaag gagacaagag cctacagctc      120

agactggagg atgaaacgat tctggaatac ccaattgatg tacaacgcaa ccagctgccc      180

ttcttacgga atccagatat cttggtggga gaaaatgacc tgactgccct tagctatctt      240

catgagcctg cagttttgca taatttgaag gtccgtttcc tggagtccaa ccatatctac      300

acttactgtg gtatcgtact tgttgccatt aatccttatg aacagttgcc aatctatgga      360

caagatgtca tctataccta cagtggccaa aacatgggag acatggaccc ccacatcttt      420

gctgtggcag aagaagccta caagcagatg gccagagatg agaagaatca gtccatcata      480

gtcagtgggg agtctggagc cgggaagacg gtatcagcca agtatgccat gcgctatttc      540

gccaccgttg gtggctcggc cagtgaaacc aacatcgaag agaaggtgct ggcatccagt      600

cccatcatgg aggccattgg aaatgccaag accacccgca atgacaacag cagccgtttt      660

ggcaagtaca tccagattgg ctttgacaaa aggtaccaca tcatcggggc caacatgagg      720

acttacctct tggagaagtc cagagtggtc ttccaggcag atgatgagag gaattaccac      780

atcttttacc agctctgtgc tgctgccggt cttccagaat ttaaagagct tgcactaaca      840

agtgcagagg actttttcta tacatcacag ggaggagaca cttccatcga gggtgtggac      900

gatgctgagg actttgagaa gactcgacaa gccttcacac tcctcggagt gaaagagtcc      960

catcagatga gcatttttaa gataattgct tctatcttgc accttggaag tgtggcgatt     1020

caggctgagc gtgatggtga ttcctgtagt atatcacccc aggatgtata cctaagcaac     1080

ttctgccgac tgctaggggt ggagcacagt cagatggagc actggctgtg tcatcgcaag     1140

ctggtcacca cctcggagac ctacgtcaag accatgtccc tgcagcaggt gatcaatgcg     1200

cgcaacgccc tggcgaagca catctatgcc cagttgttcg gctggattgt ggagcacatc     1260

aacaaggccc tgcacacctc cctcaagcag cactccttca tcggggtcct ggacatctat     1320

gggtttgaga catttgaggt aaacagcttt gagcagttct gtatcaacta tgcaaatgaa     1380

aagctccagc agcagttcaa ctcgcatgtt ttcaaactgg agcaagaaga atacatgaag     1440

gaacagatcc cttggaccct gattgatttt tatgataacc aaccttgtat cgacctcatt     1500

gaagccaagc tgggtatctt ggacctgttg gatgaagaat gtaaggtccc caaaggaact     1560

gaccagaact gggctcagaa gctctatgac cggcactcca gcagccagca cttccagaag     1620

ccccgcatgt ccaacacggc cttcatcatc gtccactttg cagacaaggt ggagtacctc     1680

tctgatggtt ttctggagaa aaacagagac acggtgtatg aagagcagat caatatcctg     1740

aaggccagca agttcccact agtggctgac ttgtttcatg atgacaagga ccctgttcct     1800

gccaccaccc ctgggaaggg gtcatcttcg aagatcagcg tccgttctgc cagacccccc     1860

atgaaagtct ccaacaagga gcacaagaaa accgttggcc accagttccg tacctccctg     1920

catctgctca tggagaccct gaatgccacg acacctcact atgtccgctg catcaagccc     1980

aacgatgaga agctcccctt tcactttgac ccaaagagag cagtgcagca actcagagcc     2040

tgcggggtgt tggagacgat tcgaatcagt gcagctggct acccatccag gtgggcctac     2100

catgactttt tcaaccggta tcgggtgctg gtcaagaaga gagagctcgc caacacagac     2160

aaaaaggcca tctgcaggtc tgtcctggag aacctcatca aggaccccga caagttccag     2220

tttggccgca ccaagatctt ctttcgagca ggccaggtgg cctacctgga gaagctgcgg     2280

gctgacaagt tccggacagc caccatcatg atccagaaaa ctgtccgggg atggctgcag     2340

aaggtgaaat atcacaggct gaagggggct accttaaccc tgcagaggta ctgccgggga     2400

cacctggccc gcaggctggc tgagcacctg cggaggatca gagcggctgt ggtgctccag     2460

aaacattacc gcatgcagag ggcccgccag gcctaccaga gggtccgcag agctgccgtt     2520

gttatccagg ccttcacccg ggccatgttt gtgcggagaa cctaccgcca ggtcctcatg     2580

gagcacaagg ccaccaccat ccagaagcac gtgcggggct ggatggcacg caggcacttc     2640

cagcggctgc gggatgcagc cattgtcatc cagtgtgcct tccggatgct caaggccagg     2700

cgggagctga aggccctcag gattgaggcc cgctcagcag agcatctgaa acgtctcaac     2760

gtgggcatgg agaacaaggt ggtccagctg cagcggaaga tcgatgagca gaacaaagag     2820

ttcaagacac tttcagagca gttgtccgtg accacctcaa catacaccat ggaggtagag     2880

cggctgaaga aggagctggt gcactaccag cagagcccag gtgaggacac cagcctcagg     2940

ctgcaggagg aggtggagag cctgcgcaca gagctgcaga gggcccactc ggagcgcaag     3000

atcttggagg acgcccacag cagggagaaa gatgagctga ggaagcgagt tgcagacctg     3060

gagcaagaaa atgctctctt gaaagatgag aaagaacagc tcaacaacca aatcctgtgc     3120

cagtctaaag atgaatttgc ccagaactct gtgaaggaaa atctcatgaa gaaagaactg     3180

gaggaggagc gatcccggta ccagaacctt gtgaaggaat attcacagtt ggagcagaga     3240

tacgacaacc ttcgggatga aatgaccatc ataaagcaaa ctccaggtca taggcggaac     3300

ccatcaaacc aaagtagctt agaatctgac tccaattacc cctccatctc cacatctgag     3360

atcggagaca ctgaggatgc cctccagcag gtggaggaaa ttggcctgga gaaggcagcc     3420

atggacatga cggtcttcct gaagctgcag aagagagtac gggagctgga gcaggagagg     3480

aaaaagctgc aagtgcagct ggagaagaga gaacagcagg acagcaagaa agtccaggcg     3540

gaaccaccac agactgacat agatttggac ccgaatgcag atctggccta caatagtctg     3600

aagaggcaag agctggagtc agagaacaaa aagctgaaga atgacctgaa tgagctgagg     3660

aaagccgtgg ccgaccaagc cacgcagaat aactccagcc acggctcccc agatagctac     3720

agcctcctgc tgaaccagct caagctggcc cacgaggagc tcgaggtgcg caaggaggag     3780

gtgctcatcc tcaggaccca gatcgtgagc gccgaccagc ggcgactcgc cggcaggaac     3840

gcggagccga acattaatgc cagatcaagt tggcctaaca gtgaaaagca tgttgaccag     3900

gaggatgcca ttgaggccta tcacggggtc tgccagacaa acagcaagac tgaggattgg     3960

ggatatttaa atgaagatgg agaactcggc ttggcctacc aaggcctaaa gcaagttgcc     4020

aggctgctgg aggctcagct gcaggcccag agcctggagc atgaggagga ggtggagcat     4080

ctcaaggctc agctcgaggc cctgaaggag gagatggaca aacagcagca gaccttctgc     4140

cagacgctac tgctctcccc agaggcccag gtggaattcg gcgttcagca ggaaatatcc     4200

cggctgacca acgagaatct ggaccttaaa gaactggtag aaaagctgga aaagaatgag     4260

aggaagctca aaaagcaact gaagatttac atgaagaaag cccaggacct agaagctgcc     4320

caggcattgg cccagagtga gaggaagcgc catgagctca acaggcaggt cacggtccag     4380

cggaaagaga aggatttcca gggcatgctg gagtaccaca aagaggacga ggccctcctc     4440

atccggaacc tggtgacaga cttgaagccc cagatgctgt cgggcacagt gccctgtctc     4500

cccgcctaca tcctctacat gtgcatccgg cacgcggact acaccaacga cgatctcaag     4560

gtgcactccc tgctgacctc caccatcaac ggcattaaga aagtcctgaa aaagcacaat     4620

gatgactttg agatgacgtc attctggtta tccaacacct gccgccttct tcactgtctg     4680

aagcagtaca gcggggatga gggcttcatg actcagaaca ctgcaaagca gaatgaacac     4740

tgtcttaaga attttgacct caccgaatac cgtcaggtgc tgagtgacct ttccattcag     4800

atctaccagc agctcattaa aattgccgag ggcgtgttac agccgatgat agtttctgcc     4860

atgttggaaa atgagagcat tcagggtcta tctggtgtga agcccaccgg ctaccggaag     4920

cgctcctcca gcatggcaga tggggataac tcatactgcc tggaagctat catccgccag     4980

atgaatgcct ttcatacagt catgtgtgac cagggcttgg accctgagat catcctgcag     5040

gtattcaaac agctcttcta catgatcaac gcagtgactc ttaacaacct gctcttgcgg     5100

aaggacgtct gctcttggag cacaggcatg caactcaggt acaatataag tcagcttgag     5160

gagtggcttc ggggaagaaa ccttcaccag agtggagcag ttcagaccat ggaacctctg     5220

atccaagcag cccagctcct gcaattaaag aagaaaaccc aggaggacgc agaggctatc     5280

tgctccctgt gtacctccct cagcacccag cagattgtca aaattttaaa cctttatact     5340

cccctgaatg aatttgaaga acgggtaaca gtggccttta tacgaacaat ccaggcacaa     5400

ctacaagagc ggaatgaccc tcagcaactg ctattagatg ccaagcacat gtttcctgtt     5460

ttgtttccat ttaatccatc ttctctaacc atggactcaa tccacatccc agcgtgtctc     5520

aatctggaat tcctcaatga agtctga                                         5547


<210>  12
<211>  1848
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Val Gly Glu Leu Tyr Ser Gln Cys Thr Arg Val Trp Ile Pro 
1               5                   10                  15      


Asp Pro Asp Glu Val Trp Arg Ser Ala Glu Leu Thr Lys Asp Tyr Lys 
            20                  25                  30          


Glu Gly Asp Lys Ser Leu Gln Leu Arg Leu Glu Asp Glu Thr Ile Leu 
        35                  40                  45              


Glu Tyr Pro Ile Asp Val Gln Arg Asn Gln Leu Pro Phe Leu Arg Asn 
    50                  55                  60                  


Pro Asp Ile Leu Val Gly Glu Asn Asp Leu Thr Ala Leu Ser Tyr Leu 
65                  70                  75                  80  


His Glu Pro Ala Val Leu His Asn Leu Lys Val Arg Phe Leu Glu Ser 
                85                  90                  95      


Asn His Ile Tyr Thr Tyr Cys Gly Ile Val Leu Val Ala Ile Asn Pro 
            100                 105                 110         


Tyr Glu Gln Leu Pro Ile Tyr Gly Gln Asp Val Ile Tyr Thr Tyr Ser 
        115                 120                 125             


Gly Gln Asn Met Gly Asp Met Asp Pro His Ile Phe Ala Val Ala Glu 
    130                 135                 140                 


Glu Ala Tyr Lys Gln Met Ala Arg Asp Glu Lys Asn Gln Ser Ile Ile 
145                 150                 155                 160 


Val Ser Gly Glu Ser Gly Ala Gly Lys Thr Val Ser Ala Lys Tyr Ala 
                165                 170                 175     


Met Arg Tyr Phe Ala Thr Val Gly Gly Ser Ala Ser Glu Thr Asn Ile 
            180                 185                 190         


Glu Glu Lys Val Leu Ala Ser Ser Pro Ile Met Glu Ala Ile Gly Asn 
        195                 200                 205             


Ala Lys Thr Thr Arg Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Ile 
    210                 215                 220                 


Gln Ile Gly Phe Asp Lys Arg Tyr His Ile Ile Gly Ala Asn Met Arg 
225                 230                 235                 240 


Thr Tyr Leu Leu Glu Lys Ser Arg Val Val Phe Gln Ala Asp Asp Glu 
                245                 250                 255     


Arg Asn Tyr His Ile Phe Tyr Gln Leu Cys Ala Ala Ala Gly Leu Pro 
            260                 265                 270         


Glu Phe Lys Glu Leu Ala Leu Thr Ser Ala Glu Asp Phe Phe Tyr Thr 
        275                 280                 285             


Ser Gln Gly Gly Asp Thr Ser Ile Glu Gly Val Asp Asp Ala Glu Asp 
    290                 295                 300                 


Phe Glu Lys Thr Arg Gln Ala Phe Thr Leu Leu Gly Val Lys Glu Ser 
305                 310                 315                 320 


His Gln Met Ser Ile Phe Lys Ile Ile Ala Ser Ile Leu His Leu Gly 
                325                 330                 335     


Ser Val Ala Ile Gln Ala Glu Arg Asp Gly Asp Ser Cys Ser Ile Ser 
            340                 345                 350         


Pro Gln Asp Val Tyr Leu Ser Asn Phe Cys Arg Leu Leu Gly Val Glu 
        355                 360                 365             


His Ser Gln Met Glu His Trp Leu Cys His Arg Lys Leu Val Thr Thr 
    370                 375                 380                 


Ser Glu Thr Tyr Val Lys Thr Met Ser Leu Gln Gln Val Ile Asn Ala 
385                 390                 395                 400 


Arg Asn Ala Leu Ala Lys His Ile Tyr Ala Gln Leu Phe Gly Trp Ile 
                405                 410                 415     


Val Glu His Ile Asn Lys Ala Leu His Thr Ser Leu Lys Gln His Ser 
            420                 425                 430         


Phe Ile Gly Val Leu Asp Ile Tyr Gly Phe Glu Thr Phe Glu Val Asn 
        435                 440                 445             


Ser Phe Glu Gln Phe Cys Ile Asn Tyr Ala Asn Glu Lys Leu Gln Gln 
    450                 455                 460                 


Gln Phe Asn Ser His Val Phe Lys Leu Glu Gln Glu Glu Tyr Met Lys 
465                 470                 475                 480 


Glu Gln Ile Pro Trp Thr Leu Ile Asp Phe Tyr Asp Asn Gln Pro Cys 
                485                 490                 495     


Ile Asp Leu Ile Glu Ala Lys Leu Gly Ile Leu Asp Leu Leu Asp Glu 
            500                 505                 510         


Glu Cys Lys Val Pro Lys Gly Thr Asp Gln Asn Trp Ala Gln Lys Leu 
        515                 520                 525             


Tyr Asp Arg His Ser Ser Ser Gln His Phe Gln Lys Pro Arg Met Ser 
    530                 535                 540                 


Asn Thr Ala Phe Ile Ile Val His Phe Ala Asp Lys Val Glu Tyr Leu 
545                 550                 555                 560 


Ser Asp Gly Phe Leu Glu Lys Asn Arg Asp Thr Val Tyr Glu Glu Gln 
                565                 570                 575     


Ile Asn Ile Leu Lys Ala Ser Lys Phe Pro Leu Val Ala Asp Leu Phe 
            580                 585                 590         


His Asp Asp Lys Asp Pro Val Pro Ala Thr Thr Pro Gly Lys Gly Ser 
        595                 600                 605             


Ser Ser Lys Ile Ser Val Arg Ser Ala Arg Pro Pro Met Lys Val Ser 
    610                 615                 620                 


Asn Lys Glu His Lys Lys Thr Val Gly His Gln Phe Arg Thr Ser Leu 
625                 630                 635                 640 


His Leu Leu Met Glu Thr Leu Asn Ala Thr Thr Pro His Tyr Val Arg 
                645                 650                 655     


Cys Ile Lys Pro Asn Asp Glu Lys Leu Pro Phe His Phe Asp Pro Lys 
            660                 665                 670         


Arg Ala Val Gln Gln Leu Arg Ala Cys Gly Val Leu Glu Thr Ile Arg 
        675                 680                 685             


Ile Ser Ala Ala Gly Tyr Pro Ser Arg Trp Ala Tyr His Asp Phe Phe 
    690                 695                 700                 


Asn Arg Tyr Arg Val Leu Val Lys Lys Arg Glu Leu Ala Asn Thr Asp 
705                 710                 715                 720 


Lys Lys Ala Ile Cys Arg Ser Val Leu Glu Asn Leu Ile Lys Asp Pro 
                725                 730                 735     


Asp Lys Phe Gln Phe Gly Arg Thr Lys Ile Phe Phe Arg Ala Gly Gln 
            740                 745                 750         


Val Ala Tyr Leu Glu Lys Leu Arg Ala Asp Lys Phe Arg Thr Ala Thr 
        755                 760                 765             


Ile Met Ile Gln Lys Thr Val Arg Gly Trp Leu Gln Lys Val Lys Tyr 
    770                 775                 780                 


His Arg Leu Lys Gly Ala Thr Leu Thr Leu Gln Arg Tyr Cys Arg Gly 
785                 790                 795                 800 


His Leu Ala Arg Arg Leu Ala Glu His Leu Arg Arg Ile Arg Ala Ala 
                805                 810                 815     


Val Val Leu Gln Lys His Tyr Arg Met Gln Arg Ala Arg Gln Ala Tyr 
            820                 825                 830         


Gln Arg Val Arg Arg Ala Ala Val Val Ile Gln Ala Phe Thr Arg Ala 
        835                 840                 845             


Met Phe Val Arg Arg Thr Tyr Arg Gln Val Leu Met Glu His Lys Ala 
    850                 855                 860                 


Thr Thr Ile Gln Lys His Val Arg Gly Trp Met Ala Arg Arg His Phe 
865                 870                 875                 880 


Gln Arg Leu Arg Asp Ala Ala Ile Val Ile Gln Cys Ala Phe Arg Met 
                885                 890                 895     


Leu Lys Ala Arg Arg Glu Leu Lys Ala Leu Arg Ile Glu Ala Arg Ser 
            900                 905                 910         


Ala Glu His Leu Lys Arg Leu Asn Val Gly Met Glu Asn Lys Val Val 
        915                 920                 925             


Gln Leu Gln Arg Lys Ile Asp Glu Gln Asn Lys Glu Phe Lys Thr Leu 
    930                 935                 940                 


Ser Glu Gln Leu Ser Val Thr Thr Ser Thr Tyr Thr Met Glu Val Glu 
945                 950                 955                 960 


Arg Leu Lys Lys Glu Leu Val His Tyr Gln Gln Ser Pro Gly Glu Asp 
                965                 970                 975     


Thr Ser Leu Arg Leu Gln Glu Glu Val Glu Ser Leu Arg Thr Glu Leu 
            980                 985                 990         


Gln Arg Ala His Ser Glu Arg Lys  Ile Leu Glu Asp Ala  His Ser Arg 
        995                 1000                 1005             


Glu Lys  Asp Glu Leu Arg Lys  Arg Val Ala Asp Leu  Glu Gln Glu 
    1010                 1015                 1020             


Asn Ala  Leu Leu Lys Asp Glu  Lys Glu Gln Leu Asn  Asn Gln Ile 
    1025                 1030                 1035             


Leu Cys  Gln Ser Lys Asp Glu  Phe Ala Gln Asn Ser  Val Lys Glu 
    1040                 1045                 1050             


Asn Leu  Met Lys Lys Glu Leu  Glu Glu Glu Arg Ser  Arg Tyr Gln 
    1055                 1060                 1065             


Asn Leu  Val Lys Glu Tyr Ser  Gln Leu Glu Gln Arg  Tyr Asp Asn 
    1070                 1075                 1080             


Leu Arg  Asp Glu Met Thr Ile  Ile Lys Gln Thr Pro  Gly His Arg 
    1085                 1090                 1095             


Arg Asn  Pro Ser Asn Gln Ser  Ser Leu Glu Ser Asp  Ser Asn Tyr 
    1100                 1105                 1110             


Pro Ser  Ile Ser Thr Ser Glu  Ile Gly Asp Thr Glu  Asp Ala Leu 
    1115                 1120                 1125             


Gln Gln  Val Glu Glu Ile Gly  Leu Glu Lys Ala Ala  Met Asp Met 
    1130                 1135                 1140             


Thr Val  Phe Leu Lys Leu Gln  Lys Arg Val Arg Glu  Leu Glu Gln 
    1145                 1150                 1155             


Glu Arg  Lys Lys Leu Gln Val  Gln Leu Glu Lys Arg  Glu Gln Gln 
    1160                 1165                 1170             


Asp Ser  Lys Lys Val Gln Ala  Glu Pro Pro Gln Thr  Asp Ile Asp 
    1175                 1180                 1185             


Leu Asp  Pro Asn Ala Asp Leu  Ala Tyr Asn Ser Leu  Lys Arg Gln 
    1190                 1195                 1200             


Glu Leu  Glu Ser Glu Asn Lys  Lys Leu Lys Asn Asp  Leu Asn Glu 
    1205                 1210                 1215             


Leu Arg  Lys Ala Val Ala Asp  Gln Ala Thr Gln Asn  Asn Ser Ser 
    1220                 1225                 1230             


His Gly  Ser Pro Asp Ser Tyr  Ser Leu Leu Leu Asn  Gln Leu Lys 
    1235                 1240                 1245             


Leu Ala  His Glu Glu Leu Glu  Val Arg Lys Glu Glu  Val Leu Ile 
    1250                 1255                 1260             


Leu Arg  Thr Gln Ile Val Ser  Ala Asp Gln Arg Arg  Leu Ala Gly 
    1265                 1270                 1275             


Arg Asn  Ala Glu Pro Asn Ile  Asn Ala Arg Ser Ser  Trp Pro Asn 
    1280                 1285                 1290             


Ser Glu  Lys His Val Asp Gln  Glu Asp Ala Ile Glu  Ala Tyr His 
    1295                 1300                 1305             


Gly Val  Cys Gln Thr Asn Ser  Lys Thr Glu Asp Trp  Gly Tyr Leu 
    1310                 1315                 1320             


Asn Glu  Asp Gly Glu Leu Gly  Leu Ala Tyr Gln Gly  Leu Lys Gln 
    1325                 1330                 1335             


Val Ala  Arg Leu Leu Glu Ala  Gln Leu Gln Ala Gln  Ser Leu Glu 
    1340                 1345                 1350             


His Glu  Glu Glu Val Glu His  Leu Lys Ala Gln Leu  Glu Ala Leu 
    1355                 1360                 1365             


Lys Glu  Glu Met Asp Lys Gln  Gln Gln Thr Phe Cys  Gln Thr Leu 
    1370                 1375                 1380             


Leu Leu  Ser Pro Glu Ala Gln  Val Glu Phe Gly Val  Gln Gln Glu 
    1385                 1390                 1395             


Ile Ser  Arg Leu Thr Asn Glu  Asn Leu Asp Leu Lys  Glu Leu Val 
    1400                 1405                 1410             


Glu Lys  Leu Glu Lys Asn Glu  Arg Lys Leu Lys Lys  Gln Leu Lys 
    1415                 1420                 1425             


Ile Tyr  Met Lys Lys Ala Gln  Asp Leu Glu Ala Ala  Gln Ala Leu 
    1430                 1435                 1440             


Ala Gln  Ser Glu Arg Lys Arg  His Glu Leu Asn Arg  Gln Val Thr 
    1445                 1450                 1455             


Val Gln  Arg Lys Glu Lys Asp  Phe Gln Gly Met Leu  Glu Tyr His 
    1460                 1465                 1470             


Lys Glu  Asp Glu Ala Leu Leu  Ile Arg Asn Leu Val  Thr Asp Leu 
    1475                 1480                 1485             


Lys Pro  Gln Met Leu Ser Gly  Thr Val Pro Cys Leu  Pro Ala Tyr 
    1490                 1495                 1500             


Ile Leu  Tyr Met Cys Ile Arg  His Ala Asp Tyr Thr  Asn Asp Asp 
    1505                 1510                 1515             


Leu Lys  Val His Ser Leu Leu  Thr Ser Thr Ile Asn  Gly Ile Lys 
    1520                 1525                 1530             


Lys Val  Leu Lys Lys His Asn  Asp Asp Phe Glu Met  Thr Ser Phe 
    1535                 1540                 1545             


Trp Leu  Ser Asn Thr Cys Arg  Leu Leu His Cys Leu  Lys Gln Tyr 
    1550                 1555                 1560             


Ser Gly  Asp Glu Gly Phe Met  Thr Gln Asn Thr Ala  Lys Gln Asn 
    1565                 1570                 1575             


Glu His  Cys Leu Lys Asn Phe  Asp Leu Thr Glu Tyr  Arg Gln Val 
    1580                 1585                 1590             


Leu Ser  Asp Leu Ser Ile Gln  Ile Tyr Gln Gln Leu  Ile Lys Ile 
    1595                 1600                 1605             


Ala Glu  Gly Val Leu Gln Pro  Met Ile Val Ser Ala  Met Leu Glu 
    1610                 1615                 1620             


Asn Glu  Ser Ile Gln Gly Leu  Ser Gly Val Lys Pro  Thr Gly Tyr 
    1625                 1630                 1635             


Arg Lys  Arg Ser Ser Ser Met  Ala Asp Gly Asp Asn  Ser Tyr Cys 
    1640                 1645                 1650             


Leu Glu  Ala Ile Ile Arg Gln  Met Asn Ala Phe His  Thr Val Met 
    1655                 1660                 1665             


Cys Asp  Gln Gly Leu Asp Pro  Glu Ile Ile Leu Gln  Val Phe Lys 
    1670                 1675                 1680             


Gln Leu  Phe Tyr Met Ile Asn  Ala Val Thr Leu Asn  Asn Leu Leu 
    1685                 1690                 1695             


Leu Arg  Lys Asp Val Cys Ser  Trp Ser Thr Gly Met  Gln Leu Arg 
    1700                 1705                 1710             


Tyr Asn  Ile Ser Gln Leu Glu  Glu Trp Leu Arg Gly  Arg Asn Leu 
    1715                 1720                 1725             


His Gln  Ser Gly Ala Val Gln  Thr Met Glu Pro Leu  Ile Gln Ala 
    1730                 1735                 1740             


Ala Gln  Leu Leu Gln Leu Lys  Lys Lys Thr Gln Glu  Asp Ala Glu 
    1745                 1750                 1755             


Ala Ile  Cys Ser Leu Cys Thr  Ser Leu Ser Thr Gln  Gln Ile Val 
    1760                 1765                 1770             


Lys Ile  Leu Asn Leu Tyr Thr  Pro Leu Asn Glu Phe  Glu Glu Arg 
    1775                 1780                 1785             


Val Thr  Val Ala Phe Ile Arg  Thr Ile Gln Ala Gln  Leu Gln Glu 
    1790                 1795                 1800             


Arg Asn  Asp Pro Gln Gln Leu  Leu Leu Asp Ala Lys  His Met Phe 
    1805                 1810                 1815             


Pro Val  Leu Phe Pro Phe Asn  Pro Ser Ser Leu Thr  Met Asp Ser 
    1820                 1825                 1830             


Ile His  Ile Pro Ala Cys Leu  Asn Leu Glu Phe Leu  Asn Glu Val 
    1835                 1840                 1845             


<210>  13
<211>  624
<212>  DNA
<213>  Homo sapiens

<400>  13
atggcgaaga cctacgatta cctgttcaag ctgctgctga tcggggactc gggggtgggg       60

aagacctgtg tcctgttccg cttctccgag gacgccttca actccacttt tatctccacc      120

ataggaattg actttaaaat taggaccata gagctcgatg gcaagagaat taaactgcag      180

atatgggaca cagccggtca ggaacggttt cggacgatca caacggccta ctacaggggt      240

gcaatgggca tcatgctggt ctacgacatc accaacgaga agtccttcga caacatccgg      300

aactggattc gcaacattga ggagcacgcc tctgcagacg tcgaaaagat gatactcggg      360

aacaagtgtg atgtgaatga caagagacaa gtttccaagg aacggggaga aaagctggcc      420

ctcgactatg gaatcaagtt catggagacc agcgcgaagg ccaacatcaa tgtggaaaat      480

gcatttttca ctctcgccag agatatcaaa gcaaaaatgg acaaaaaatt ggaaggcaac      540

agcccccagg ggagcaacca gggagtcaaa atcacaccgg accagcagaa gaggagcagc      600

tttttccgat gtgttcttct gtga                                             624


<210>  14
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Lys Thr Tyr Asp Tyr Leu Phe Lys Leu Leu Leu Ile Gly Asp 
1               5                   10                  15      


Ser Gly Val Gly Lys Thr Cys Val Leu Phe Arg Phe Ser Glu Asp Ala 
            20                  25                  30          


Phe Asn Ser Thr Phe Ile Ser Thr Ile Gly Ile Asp Phe Lys Ile Arg 
        35                  40                  45              


Thr Ile Glu Leu Asp Gly Lys Arg Ile Lys Leu Gln Ile Trp Asp Thr 
    50                  55                  60                  


Ala Gly Gln Glu Arg Phe Arg Thr Ile Thr Thr Ala Tyr Tyr Arg Gly 
65                  70                  75                  80  


Ala Met Gly Ile Met Leu Val Tyr Asp Ile Thr Asn Glu Lys Ser Phe 
                85                  90                  95      


Asp Asn Ile Arg Asn Trp Ile Arg Asn Ile Glu Glu His Ala Ser Ala 
            100                 105                 110         


Asp Val Glu Lys Met Ile Leu Gly Asn Lys Cys Asp Val Asn Asp Lys 
        115                 120                 125             


Arg Gln Val Ser Lys Glu Arg Gly Glu Lys Leu Ala Leu Asp Tyr Gly 
    130                 135                 140                 


Ile Lys Phe Met Glu Thr Ser Ala Lys Ala Asn Ile Asn Val Glu Asn 
145                 150                 155                 160 


Ala Phe Phe Thr Leu Ala Arg Asp Ile Lys Ala Lys Met Asp Lys Lys 
                165                 170                 175     


Leu Glu Gly Asn Ser Pro Gln Gly Ser Asn Gln Gly Val Lys Ile Thr 
            180                 185                 190         


Pro Asp Gln Gln Lys Arg Ser Ser Phe Phe Arg Cys Val Leu Leu 
        195                 200                 205         


<210>  15
<211>  606
<212>  DNA
<213>  Homo sapiens

<400>  15
atggcaggaa aatcatcact ttttaaagta attctccttg gagatggtgg agttgggaag       60

agttcactta tgaacagata tgtaactaat aagtttgata cccagctctt ccatacaata      120

ggtgtggaat ttttaaataa agatttggaa gtggatggac attttgttac catgcagatt      180

tgggacacgg caggtcagga gcgattccga agcctgagga caccatttta cagaggttct      240

gactgctgcc tgcttacttt tagtgtcgat gattcacaaa gcttccagaa cttaagtaac      300

tggaagaaag aattcatata ttatgcagat gtgaaagagc ctgagagctt tccttttgtg      360

attctgggta acaagattga cataagcgaa cggcaggtgt ctacagaaga agcccaagct      420

tggtgcaggg acaacggcga ctatccttat tttgaaacaa gtgcaaaaga tgccacaaat      480

gtggcagcag cctttgagga agcggttcga agagttcttg ctaccgagga taggtcagat      540

catttgattc agacagacac agtcaatctt caccgaaagc ccaagcctag ctcatcttgc      600

tgttga                                                                 606


<210>  16
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Gly Lys Ser Ser Leu Phe Lys Val Ile Leu Leu Gly Asp Gly 
1               5                   10                  15      


Gly Val Gly Lys Ser Ser Leu Met Asn Arg Tyr Val Thr Asn Lys Phe 
            20                  25                  30          


Asp Thr Gln Leu Phe His Thr Ile Gly Val Glu Phe Leu Asn Lys Asp 
        35                  40                  45              


Leu Glu Val Asp Gly His Phe Val Thr Met Gln Ile Trp Asp Thr Ala 
    50                  55                  60                  


Gly Gln Glu Arg Phe Arg Ser Leu Arg Thr Pro Phe Tyr Arg Gly Ser 
65                  70                  75                  80  


Asp Cys Cys Leu Leu Thr Phe Ser Val Asp Asp Ser Gln Ser Phe Gln 
                85                  90                  95      


Asn Leu Ser Asn Trp Lys Lys Glu Phe Ile Tyr Tyr Ala Asp Val Lys 
            100                 105                 110         


Glu Pro Glu Ser Phe Pro Phe Val Ile Leu Gly Asn Lys Ile Asp Ile 
        115                 120                 125             


Ser Glu Arg Gln Val Ser Thr Glu Glu Ala Gln Ala Trp Cys Arg Asp 
    130                 135                 140                 


Asn Gly Asp Tyr Pro Tyr Phe Glu Thr Ser Ala Lys Asp Ala Thr Asn 
145                 150                 155                 160 


Val Ala Ala Ala Phe Glu Glu Ala Val Arg Arg Val Leu Ala Thr Glu 
                165                 170                 175     


Asp Arg Ser Asp His Leu Ile Gln Thr Asp Thr Val Asn Leu His Arg 
            180                 185                 190         


Lys Pro Lys Pro Ser Ser Ser Cys Cys 
        195                 200     


<210>  17
<211>  603
<212>  DNA
<213>  Homo sapiens

<400>  17
atggcgaaga agacgtacga cctgcttttc aagctgctcc tgatcgggga ttccggagtg       60

gggaagacct gcgtcctttt tcgtttttcg gatgatgcct tcaatactac ctttatttcc      120

accataggaa tagacttcaa gatcaaaaca gttgaattac aaggaaagaa gatcaagcta      180

cagatatggg atacagcagg ccaggagcga tttcacacca tcacaacctc ctactacaga      240

ggcgcaatgg gtatcatgct agtatatgac atcaccaatg gtaaaagttt tgaaaacatc      300

agcaaatggc ttagaaacat agatgagcat gccaatgaag atgtggaaag aatgttacta      360

ggaaacaagt gtgatatgga cgacaaaaga gttgtaccta aaggaaaagg agaacagatt      420

gcaagggagc atggtattag gttttttgag actagtgcaa aagcaaatat aaacatcgaa      480

aaggcgttcc tcacgttagc tgaagatatc cttcgaaaga cccctgtaaa agagcccaac      540

agtgaaaatg tagatatcag cagtggagga ggcgtgacag gctggaagag caaatgctgc      600

tga                                                                    603


<210>  18
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Lys Lys Thr Tyr Asp Leu Leu Phe Lys Leu Leu Leu Ile Gly 
1               5                   10                  15      


Asp Ser Gly Val Gly Lys Thr Cys Val Leu Phe Arg Phe Ser Asp Asp 
            20                  25                  30          


Ala Phe Asn Thr Thr Phe Ile Ser Thr Ile Gly Ile Asp Phe Lys Ile 
        35                  40                  45              


Lys Thr Val Glu Leu Gln Gly Lys Lys Ile Lys Leu Gln Ile Trp Asp 
    50                  55                  60                  


Thr Ala Gly Gln Glu Arg Phe His Thr Ile Thr Thr Ser Tyr Tyr Arg 
65                  70                  75                  80  


Gly Ala Met Gly Ile Met Leu Val Tyr Asp Ile Thr Asn Gly Lys Ser 
                85                  90                  95      


Phe Glu Asn Ile Ser Lys Trp Leu Arg Asn Ile Asp Glu His Ala Asn 
            100                 105                 110         


Glu Asp Val Glu Arg Met Leu Leu Gly Asn Lys Cys Asp Met Asp Asp 
        115                 120                 125             


Lys Arg Val Val Pro Lys Gly Lys Gly Glu Gln Ile Ala Arg Glu His 
    130                 135                 140                 


Gly Ile Arg Phe Phe Glu Thr Ser Ala Lys Ala Asn Ile Asn Ile Glu 
145                 150                 155                 160 


Lys Ala Phe Leu Thr Leu Ala Glu Asp Ile Leu Arg Lys Thr Pro Val 
                165                 170                 175     


Lys Glu Pro Asn Ser Glu Asn Val Asp Ile Ser Ser Gly Gly Gly Val 
            180                 185                 190         


Thr Gly Trp Lys Ser Lys Cys Cys 
        195                 200 


<210>  19
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  19
atgggcaccc gcgacgacga gtacgactac ctctttaaag ttgtccttat tggagattct       60

ggtgttggaa agagtaatct cctgtctcga tttactcgaa atgagtttaa tctggaaagc      120

aagagcacca ttggagtaga gtttgcaaca agaagcatcc aggttgatgg aaaaacaata      180

aaggcacaga tatgggacac agcagggcaa gagcgatatc gagctataac atcagcatat      240

tatcgtggag ctgtaggtgc cttattggtt tatgacattg ctaaacatct cacatatgaa      300

aatgtagagc gatggctgaa agaactgaga gatcatgctg atagtaacat tgttatcatg      360

cttgtgggca ataagagtga tctacgtcat ctcagggcag ttcctacaga tgaagcaaga      420

gcttttgcag aaaagaatgg tttgtcattc attgaaactt cggccctaga ctctacaaat      480

gtagaagctg cttttcagac aattttaaca gagatttacc gcattgtttc tcagaagcaa      540

atgtcagaca gacgcgaaaa tgacatgtct ccaagcaaca atgtggttcc tattcatgtt      600

ccaccaacca ctgaaaacaa gccaaaggtg cagtgctgtc agaacatcta a               651


<210>  20
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gly Thr Arg Asp Asp Glu Tyr Asp Tyr Leu Phe Lys Val Val Leu 
1               5                   10                  15      


Ile Gly Asp Ser Gly Val Gly Lys Ser Asn Leu Leu Ser Arg Phe Thr 
            20                  25                  30          


Arg Asn Glu Phe Asn Leu Glu Ser Lys Ser Thr Ile Gly Val Glu Phe 
        35                  40                  45              


Ala Thr Arg Ser Ile Gln Val Asp Gly Lys Thr Ile Lys Ala Gln Ile 
    50                  55                  60                  


Trp Asp Thr Ala Gly Gln Glu Arg Tyr Arg Ala Ile Thr Ser Ala Tyr 
65                  70                  75                  80  


Tyr Arg Gly Ala Val Gly Ala Leu Leu Val Tyr Asp Ile Ala Lys His 
                85                  90                  95      


Leu Thr Tyr Glu Asn Val Glu Arg Trp Leu Lys Glu Leu Arg Asp His 
            100                 105                 110         


Ala Asp Ser Asn Ile Val Ile Met Leu Val Gly Asn Lys Ser Asp Leu 
        115                 120                 125             


Arg His Leu Arg Ala Val Pro Thr Asp Glu Ala Arg Ala Phe Ala Glu 
    130                 135                 140                 


Lys Asn Gly Leu Ser Phe Ile Glu Thr Ser Ala Leu Asp Ser Thr Asn 
145                 150                 155                 160 


Val Glu Ala Ala Phe Gln Thr Ile Leu Thr Glu Ile Tyr Arg Ile Val 
                165                 170                 175     


Ser Gln Lys Gln Met Ser Asp Arg Arg Glu Asn Asp Met Ser Pro Ser 
            180                 185                 190         


Asn Asn Val Val Pro Ile His Val Pro Pro Thr Thr Glu Asn Lys Pro 
        195                 200                 205             


Lys Val Gln Cys Cys Gln Asn Ile 
    210                 215     


<210>  21
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  21
atggggaatg gaactgagga agattataac tttgtcttca aggtggtgct gatcggcgaa       60

tcaggtgtgg ggaagaccaa tctactctcc cgattcacgc gcaatgagtt cagccacgac      120

agccgcacca ccatcggggt tgagttctcc acccgcactg tgatgttggg caccgctgct      180

gtcaaggctc agatctggga cacagctggc ctggagcggt accgagccat cacctcggcg      240

tactatcgtg gtgcagtggg ggccctcctg gtgtttgacc taaccaagca ccagacctat      300

gctgtggtgg agcgatggct gaaggagctc tatgaccatg ctgaagccac gatcgtcgtc      360

atgctcgtgg gtaacaaaag tgacctcagc caggcccggg aagtgcccac tgaggaggcc      420

cgaatgttcg ctgaaaacaa tggactgctc ttcctggaga cctcagccct ggactctacc      480

aatgttgagc tagcctttga gactgtcctg aaagaaatct ttgcgaaggt gtccaagcag      540

agacagaaca gcatccggac caatgccatc actctgggca gtgcccaggc tggacaggag      600

cctggccctg gggagaagag ggcctgttgc atcagcctct ga                         642


<210>  22
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Gly Asn Gly Thr Glu Glu Asp Tyr Asn Phe Val Phe Lys Val Val 
1               5                   10                  15      


Leu Ile Gly Glu Ser Gly Val Gly Lys Thr Asn Leu Leu Ser Arg Phe 
            20                  25                  30          


Thr Arg Asn Glu Phe Ser His Asp Ser Arg Thr Thr Ile Gly Val Glu 
        35                  40                  45              


Phe Ser Thr Arg Thr Val Met Leu Gly Thr Ala Ala Val Lys Ala Gln 
    50                  55                  60                  


Ile Trp Asp Thr Ala Gly Leu Glu Arg Tyr Arg Ala Ile Thr Ser Ala 
65                  70                  75                  80  


Tyr Tyr Arg Gly Ala Val Gly Ala Leu Leu Val Phe Asp Leu Thr Lys 
                85                  90                  95      


His Gln Thr Tyr Ala Val Val Glu Arg Trp Leu Lys Glu Leu Tyr Asp 
            100                 105                 110         


His Ala Glu Ala Thr Ile Val Val Met Leu Val Gly Asn Lys Ser Asp 
        115                 120                 125             


Leu Ser Gln Ala Arg Glu Val Pro Thr Glu Glu Ala Arg Met Phe Ala 
    130                 135                 140                 


Glu Asn Asn Gly Leu Leu Phe Leu Glu Thr Ser Ala Leu Asp Ser Thr 
145                 150                 155                 160 


Asn Val Glu Leu Ala Phe Glu Thr Val Leu Lys Glu Ile Phe Ala Lys 
                165                 170                 175     


Val Ser Lys Gln Arg Gln Asn Ser Ile Arg Thr Asn Ala Ile Thr Leu 
            180                 185                 190         


Gly Ser Ala Gln Ala Gly Gln Glu Pro Gly Pro Gly Glu Lys Arg Ala 
        195                 200                 205             


Cys Cys Ile Ser Leu 
    210             


<210>  23
<211>  576
<212>  DNA
<213>  Homo sapiens

<400>  23
atgcagacaa ttaagtgtgt tgttgtgggc gatggtgctg ttggtaaaac atgtctcctg       60

atatcctaca caacaaacaa atttccatcg gaatatgtac cgactgtttt tgacaactat      120

gcagtcacag ttatgattgg tggagaacca tatactcttg gactttttga tactgcaggg      180

caagaggatt atgacagatt acgaccgctg agttatccac aaacagatgt atttctagtc      240

tgtttttcag tggtctctcc atcttcattt gaaaacgtga aagaaaagtg ggtgcctgag      300

ataactcacc actgtccaaa gactcctttc ttgcttgttg ggactcaaat tgatctcaga      360

gatgacccct ctactattga gaaacttgcc aagaacaaac agaagcctat cactccagag      420

actgctgaaa agctggcccg tgacctgaag gctgtcaagt atgtggagtg ttctgcactt      480

acacagaaag gcctaaagaa tgtatttgac gaagcaatat tggctgccct ggagcctcca      540

gaaccgaaga agagccgcag gtgtgtgctg ctatga                                576


<210>  24
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gln Thr Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Lys Phe Pro Ser Glu Tyr 
            20                  25                  30          


Val Pro Thr Val Phe Asp Asn Tyr Ala Val Thr Val Met Ile Gly Gly 
        35                  40                  45              


Glu Pro Tyr Thr Leu Gly Leu Phe Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Val 
65                  70                  75                  80  


Cys Phe Ser Val Val Ser Pro Ser Ser Phe Glu Asn Val Lys Glu Lys 
                85                  90                  95      


Trp Val Pro Glu Ile Thr His His Cys Pro Lys Thr Pro Phe Leu Leu 
            100                 105                 110         


Val Gly Thr Gln Ile Asp Leu Arg Asp Asp Pro Ser Thr Ile Glu Lys 
        115                 120                 125             


Leu Ala Lys Asn Lys Gln Lys Pro Ile Thr Pro Glu Thr Ala Glu Lys 
    130                 135                 140                 


Leu Ala Arg Asp Leu Lys Ala Val Lys Tyr Val Glu Cys Ser Ala Leu 
145                 150                 155                 160 


Thr Gln Lys Gly Leu Lys Asn Val Phe Asp Glu Ala Ile Leu Ala Ala 
                165                 170                 175     


Leu Glu Pro Pro Glu Pro Lys Lys Ser Arg Arg Cys Val Leu Leu 
            180                 185                 190     


<210>  25
<211>  579
<212>  DNA
<213>  Homo sapiens

<400>  25
atgcaggcca tcaagtgtgt ggtggtggga gacggagctg taggtaaaac ttgcctactg       60

atcagttaca caaccaatgc atttcctgga gaatatatcc ctactgtctt tgacaattat      120

tctgccaatg ttatggtaga tggaaaaccg gtgaatctgg gcttatggga tacagctgga      180

caagaagatt atgacagatt acgcccccta tcctatccgc aaacagatgt gttcttaatt      240

tgcttttccc ttgtgagtcc tgcatcattt gaaaatgtcc gtgcaaagtg gtatcctgag      300

gtgcggcacc actgtcccaa cactcccatc atcctagtgg gaactaaact tgatcttagg      360

gatgataaag acacgatcga gaaactgaag gagaagaagc tgactcccat cacctatccg      420

cagggtctag ccatggctaa ggagattggt gctgtaaaat acctggagtg ctcggcgctc      480

acacagcgag gcctcaagac agtgtttgac gaagcgatcc gagcagtcct ctgcccgcct      540

cccgtgaaga agaggaagag aaaatgcctg ctgttgtaa                             579


<210>  26
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Gln Ala Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Ala Phe Pro Gly Glu Tyr 
            20                  25                  30          


Ile Pro Thr Val Phe Asp Asn Tyr Ser Ala Asn Val Met Val Asp Gly 
        35                  40                  45              


Lys Pro Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Ile 
65                  70                  75                  80  


Cys Phe Ser Leu Val Ser Pro Ala Ser Phe Glu Asn Val Arg Ala Lys 
                85                  90                  95      


Trp Tyr Pro Glu Val Arg His His Cys Pro Asn Thr Pro Ile Ile Leu 
            100                 105                 110         


Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Asp Thr Ile Glu Lys 
        115                 120                 125             


Leu Lys Glu Lys Lys Leu Thr Pro Ile Thr Tyr Pro Gln Gly Leu Ala 
    130                 135                 140                 


Met Ala Lys Glu Ile Gly Ala Val Lys Tyr Leu Glu Cys Ser Ala Leu 
145                 150                 155                 160 


Thr Gln Arg Gly Leu Lys Thr Val Phe Asp Glu Ala Ile Arg Ala Val 
                165                 170                 175     


Leu Cys Pro Pro Pro Val Lys Lys Arg Lys Arg Lys Cys Leu Leu Leu 
            180                 185                 190         


<210>  27
<211>  582
<212>  DNA
<213>  Homo sapiens

<400>  27
atggctgcca tccggaagaa actggtgatt gttggtgatg gagcctgtgg aaagacatgc       60

ttgctcatag tcttcagcaa ggaccagttc ccagaggtgt atgtgcccac agtgtttgag      120

aactatgtgg cagatatcga ggtggatgga aagcaggtag agttggcttt gtgggacaca      180

gctgggcagg aagattatga tcgcctgagg cccctctcct acccagatac cgatgttata      240

ctgatgtgtt tttccatcga cagccctgat agtttagaaa acatcccaga aaagtggacc      300

ccagaagtca agcatttctg tcccaacgtg cccatcatcc tggttgggaa taagaaggat      360

cttcggaatg atgagcacac aaggcgggag ctagccaaga tgaagcagga gccggtgaaa      420

cctgaagaag gcagagatat ggcaaacagg attggcgctt ttgggtacat ggagtgttca      480

gcaaagacca aagatggagt gagagaggtt tttgaaatgg ctacgagagc tgctctgcaa      540

gctagacgtg ggaagaaaaa atctgggtgc cttgtcttgt ga                         582


<210>  28
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Ala Ile Arg Lys Lys Leu Val Ile Val Gly Asp Gly Ala Cys 
1               5                   10                  15      


Gly Lys Thr Cys Leu Leu Ile Val Phe Ser Lys Asp Gln Phe Pro Glu 
            20                  25                  30          


Val Tyr Val Pro Thr Val Phe Glu Asn Tyr Val Ala Asp Ile Glu Val 
        35                  40                  45              


Asp Gly Lys Gln Val Glu Leu Ala Leu Trp Asp Thr Ala Gly Gln Glu 
    50                  55                  60                  


Asp Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Pro Asp Thr Asp Val Ile 
65                  70                  75                  80  


Leu Met Cys Phe Ser Ile Asp Ser Pro Asp Ser Leu Glu Asn Ile Pro 
                85                  90                  95      


Glu Lys Trp Thr Pro Glu Val Lys His Phe Cys Pro Asn Val Pro Ile 
            100                 105                 110         


Ile Leu Val Gly Asn Lys Lys Asp Leu Arg Asn Asp Glu His Thr Arg 
        115                 120                 125             


Arg Glu Leu Ala Lys Met Lys Gln Glu Pro Val Lys Pro Glu Glu Gly 
    130                 135                 140                 


Arg Asp Met Ala Asn Arg Ile Gly Ala Phe Gly Tyr Met Glu Cys Ser 
145                 150                 155                 160 


Ala Lys Thr Lys Asp Gly Val Arg Glu Val Phe Glu Met Ala Thr Arg 
                165                 170                 175     


Ala Ala Leu Gln Ala Arg Arg Gly Lys Lys Lys Ser Gly Cys Leu Val 
            180                 185                 190         


Leu 
    


