
                                SEQUENCE LISTING

<110> Fred Hutchinson Cancer Research Center
      University of Washington
      Veatch, Joshua
      Riddell, Stanley R.
      Lee, Sylvia

<120> BRAF SPECIFIC TCRS AND USES THEREOF
  

<130> 360056.454WO

<140> PCT                 
<141> 2018-08-10  

<150> US 62/544,695                 
<151> 2017-08-11

<160> 149

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 137
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR1 alpha chain variable
      domain

<400> 1
Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp
 1               5                  10                  15
Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val
            20                  25                  30
Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala
        35                  40                  45
Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr
    50                  55                  60
Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg
65                  70                  75                  80
Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile
                85                  90                  95
Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Arg
            100                 105                 110
Arg Gly Asn Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val
        115                 120                 125
Lys Pro Asn Ile Gln Asn Pro Asp Pro
    130                 135

<210> 2
<211> 135
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR2-1 alpha chain variable
      domain

<400> 2
Met Arg Leu Val Ala Arg Val Thr Val Phe Leu Thr Phe Gly Thr Ile
 1               5                  10                  15
Ile Asp Ala Lys Thr Thr Gln Pro Thr Ser Met Asp Cys Ala Glu Gly
            20                  25                  30
Arg Ala Ala Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu
        35                  40                  45
Tyr Val Tyr Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile
    50                  55                  60
Ile His Gly Leu Lys Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile
65                  70                  75                  80
Ile Thr Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr
                85                  90                  95
Leu Arg Asp Thr Ala Val Tyr Tyr Cys Ile Val Arg Ala Tyr Ser Gly
            100                 105                 110
Tyr Ser Thr Leu Thr Phe Gly Lys Gly Thr Met Leu Leu Val Ser Pro
        115                 120                 125
Asp Ile Gln Asn Pro Asp Pro
    130                 135

<210> 3
<211> 142
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR2-2 alpha chain variable
      domain

<400> 3
Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser
 1               5                  10                  15
Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu
            20                  25                  30
Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp
        35                  40                  45
Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser
    50                  55                  60
Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly
65                  70                  75                  80
Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu
                85                  90                  95
Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val
            100                 105                 110
Ile Thr Leu Asn Asn Asn Ala Gly Asn Met Leu Thr Phe Gly Gly Gly
        115                 120                 125
Thr Arg Leu Met Val Lys Pro His Ile Gln Asn Pro Asp Pro
    130                 135                 140

<210> 4
<211> 138
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR3 alpha chain variable
      domain

<400> 4
Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser
 1               5                  10                  15
Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu
            20                  25                  30
Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp
        35                  40                  45
Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser
    50                  55                  60
Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly
65                  70                  75                  80
Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu
                85                  90                  95
Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val
            100                 105                 110
Thr Ser Asn Ala Gly Lys Ser Thr Phe Gly Asp Gly Thr Thr Leu Thr
        115                 120                 125
Val Lys Pro Asn Ile Gln Asn Pro Asp Pro
    130                 135

<210> 5
<211> 132
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR1 beta chain variable domain

<400> 5
Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val
 1               5                  10                  15
Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys
            20                  25                  30
Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His
        35                  40                  45
Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile
                85                  90                  95
Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser
            100                 105                 110
Asn Glu Gly Asn Ser Gly Asn Thr Ile Tyr Phe Gly Glu Gly Ser Trp
        115                 120                 125
Leu Thr Val Val
    130

<210> 6
<211> 130
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR2 beta chain variable domain

<400> 6
Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val
 1               5                  10                  15
Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys
            20                  25                  30
Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His
        35                  40                  45
Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile
                85                  90                  95
Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser
            100                 105                 110
Gly Ala Arg Gln Ile Pro Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr
        115                 120                 125
Val Val
    130

<210> 7
<211> 140
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR3 beta chain variable domain

<400> 7
Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val
 1               5                  10                  15
Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys
            20                  25                  30
Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His
        35                  40                  45
Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile
                85                  90                  95
Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Leu Ser Ala Ala Gly Gly Gly Tyr Gly Tyr Thr Phe Asn Tyr Gly
        115                 120                 125
Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr Val Val
    130                 135                 140

<210> 8
<211> 287
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCRBV28-01

<400> 8
gatgtgaaag taacccagag ctcgagatat ctagtcaaaa ggacgggaga gaaagttttt      60
ctggaatgtg tccaggatat ggaccatgaa aatatgttct ggtatcgaca agacccaggt     120
ctggggctac ggctgatcta tttctcatat gatgttaaaa tgaaagaaaa aggagatatt     180
cctgaggggt acagtgtctc tagagagaag aaggagcgct tctccctgat tctggagtcc     240
gccagcacca accagacatc tatgtacctc tgtgccagca gtttatg                   287

<210> 9
<211> 50
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCRBJ01-03

<400> 9
ctctggaaac accatatatt ttggagaggg aagttggctc actgttgtag                 50

<210> 10
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCRBJ01-02

<400> 10
ctaactatgg ctacaccttc ggttcgggga ccaggttaac cgttgtag                   48

<210> 11
<211> 279
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCRAV21-01

<400> 11
aaacaggagg tgacgcagat tcctgcagct ctgagtgtcc cagaaggaga aaacttggtt      60
ctcaactgca gtttcactga tagcgctatt tacaacctcc agtggtttag gcaggaccct     120
gggaaaggtc tcacatctct gttgcttatt cagtcaagtc agagagagca aacaagtgga     180
agacttaatg cctcgctgga taaatcatca ggacgtagta ctttatacat tgcagcttct     240
cagcctggtg actcagccac ctacctctgt gctgtgagg                            279

<210> 12
<211> 277
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCRAV26-01

<400> 12
gatgctaaga ccacccagcc cccctccatg gattgcgctg aaggaagagc tgcaaacctg      60
ccttgtaatc actctaccat cagtggaaat gagtatgtgt attggtatcg acagattcac     120
tcccaggggc cacagtatat cattcatggt ctaaaaaaca atgaaaccaa tgaaatggcc     180
tctctgatca tcacagaaga cagaaagtcc agcaccttga tcctgcccca cgctacgctg     240
agagacactg ctgtgtacta ttgcatcgtc agagtcg                              277

<210> 13
<211> 277
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCRAV12-02

<400> 13
cagaaggagg tggagcagaa ttctggaccc ctcagtgttc cagagggagc cattgcctct      60
ctcaactgca cttacagtga ccgaggttcc cagtccttct tctggtacag acaatattct     120
gggaaaagcc ctgagttgat aatgttcata tactccaatg gtgacaaaga agatggaagg     180
tttacagcac agctcaataa agccagccag tatgtttctc tgctcatcag agactcccag     240
cccagtgatt cagccaccta cctctgtgcc gtgaaca                              277

<210> 14
<211> 54
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCRAJ43-01

<400> 14
acaataacaa tgacatgcgc tttggagcag ggaccagact gacagtaaaa ccaa            54

<210> 15
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCRAJ11-01

<400> 15
tgaattcagg atacagcacc ctcacctttg ggaaggggac tatgcttcta gtctctccag      60

<210> 16
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCRAJ39-01

<400> 16
tgaataataa tgcaggcaac atgctcacct ttggaggggg aacaaggtta atggtcaaac      60
ccc                                                                    63

<210> 17
<211> 59
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCRAJ27-01

<400> 17
taacaccaat gcaggcaaat caacctttgg ggatgggact acgctcactg tgaagccaa       59

<210> 18
<211> 409
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR1 alpha chain variable
      domain

<400> 18
atggaaacac tgctgggcct gctgatcctg tggctgcaac tgcaatgggt gtccagcaag      60
caagaagtga ctcagatccc tgccgctctg tctgtgcctg agggcgaaaa cctggtcctg     120
aactgcagct tcaccgacag cgccatctac aacctgcagt ggttcaggca ggatccaggc     180
aagggcctga catccctgct gctgattcag agcagccaga gagagcagac cagcggcaga     240
ctgaatgcca gcctggataa gtcctccggc agaagcaccc tgtatatcgc cgcttctcag     300
ccaggcgata gcgccacata tctgtgtgcc gttcggagag gcaacaacga catgagattc     360
ggagccggca ccagactgac cgtgaagccc aacattcaga accccgatc                 409

<210> 19
<211> 403
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR2-1 alpha chain variable
      domain

<400> 19
atgagactgg tggccagagt gacagtgttc ctgaccttcg gcaccatcat cgacgccaag      60
accacacagc ccaccagcat ggattgtgcc gagggcagag ctgccaacct gccttgtaat     120
cacagcacca tcagcggcaa cgagtacgtg tactggtaca ggcagatcca ctctcagggc     180
cctcagtaca tcatccacgg cctgaagaac aacgagacaa acgagatggc ctctctgatc     240
atcaccgagg accgcaagag cagcaccctg attctgcctc acgccacact gagagacacc     300
gccgtgtact actgtatcgt gcgggcctac agcggctaca gcacactgac atttggcaag     360
ggcaccatgc tgctcgtgtc cccagacatt cagaaccccg atc                       403

<210> 20
<211> 424
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR2-2 alpha chain variable
      domain

<400> 20
atgaagtccc tgagagtgct gctggtcatc ctgtggctgc agctgtcttg ggtctggtcc      60
cagcagaaag aggtggaaca gaacagcggc cctctgtctg ttcctgaagg cgctatcgcc     120
tctctgaatt gcacctacag cgacagaggc agccagagct tcttctggta tcggcagtac     180
agcggcaaga gccccgagct gatcatgttc atctacagca acggcgacaa agaggacggc     240
cggtttacag cccagctgaa caaggccagc cagtacgtgt cactgctgat cagagacagc     300
cagcctagcg acagcgccac ctatctgtgt gccgtgatca ccctgaacaa caacgccggc     360
aacatgctga cctttggcgg cggaacacgg ctgatggtta agccccacat tcagaacccc     420
gatc                                                                  424

<210> 21
<211> 412
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR3 alpha chain variable
      domain

<400> 21
atgaagtccc tgagagtgct gctggtcatc ctgtggctgc agctgtcttg ggtctggtcc      60
cagcagaaag aggtggaaca gaacagcggc cctctgtccg ttcctgaagg cgccattgct     120
agcctgaatt gcacctacag cgaccggggc agccagagct tcttctggta taggcagtac     180
agcggcaaga gccccgagct gatcatgttc atctacagca acggcgacaa agaggacggc     240
cggtttacag cccagctgaa caaggccagc cagtacgtgt cactgctgat cagagacagc     300
cagcctagcg acagcgccac ctatctgtgt gccgtgacaa gcaatgccgg caagtccaca     360
tttggcgacg gcacaaccct gaccgtgaag cccaacattc agaaccccga tc             412

<210> 22
<211> 396
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR1 beta chain variable domain

<400> 22
atgggaatta gactgctgtg cagagtggcc ttctgcttcc tggctgttgg cctggtggac      60
gtgaaagtga cccagagcag cagatacctg gtcaagagaa ccggcgagaa ggtgttcctg     120
gaatgcgtgc aggacatgga ccacgagaat atgttctggt acagacagga ccccggcctg     180
ggcctgagac tgatctactt cagctacgac gtgaagatga aggaaaaggg cgacatcccc     240
gagggctaca gcgtgtccag agagaagaaa gagcggttca gcctgatcct ggaaagcgcc     300
agcaccaacc agaccagcat gtacctgtgc gccagcaacg agggcaatag cggcaacacc     360
atctacttcg gcgaaggcag ctggctgacc gtggtg                               396

<210> 23
<211> 390
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR2 beta chain variable domain

<400> 23
atgggaatta gactgctgtg cagagtggcc ttctgcttcc tggctgttgg cctggtggac      60
gtgaaagtga cccagagcag cagatacctg gtcaagagaa ccggcgagaa ggtgttcctg     120
gaatgcgtgc aggacatgga ccacgagaat atgttctggt acagacagga ccccggcctg     180
ggcctgagac tgatctactt cagctacgac gtgaagatga aggaaaaggg cgacatcccc     240
gagggctaca gcgtgtccag agagaagaaa gagcggttca gcctgatcct ggaaagcgcc     300
agcaccaacc agaccagcat gtacctgtgt gccagcggcg ccagacagat cccttacaca     360
tttggctccg gcaccagact gaccgtggtg                                      390

<210> 24
<211> 420
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR3 beta chain variable domain

<400> 24
atgggaatta gactgctgtg cagagtggcc ttctgcttcc tggctgttgg cctggtggac      60
gtgaaagtga cccagagcag cagatacctg gtcaagagaa ccggcgagaa ggtgttcctg     120
gaatgcgtgc aggacatgga ccacgagaat atgttctggt acagacagga ccccggcctg     180
ggcctgagac tgatctactt cagctacgac gtgaagatga aggaaaaggg cgacatcccc     240
gagggctaca gcgtgtccag agagaagaaa gagcggttca gcctgatcct ggaaagcgcc     300
agcaccaacc agaccagcat gtacctgtgt gccagctctc tgtctgctgc cggcggaggc     360
tatggctaca ccttcaatta cggctacaca ttcggcagcg gcaccagact gaccgtggtg     420

<210> 25
<211> 134
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR alpha chain constant domain

<400> 25
Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys
 1               5                  10                  15
Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp
            20                  25                  30
Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met
        35                  40                  45
Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe
    50                  55                  60
Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe
65                  70                  75                  80
Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser
                85                  90                  95
Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly
            100                 105                 110
Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr
        115                 120                 125
Leu Arg Leu Trp Ser Ser
    130

<210> 26
<211> 177
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR beta chain constant domain

<400> 26
Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro
 1               5                  10                  15
Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu
            20                  25                  30
Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn
        35                  40                  45
Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys
    50                  55                  60
Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu
65                  70                  75                  80
Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys
                85                  90                  95
Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp
            100                 105                 110
Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg
        115                 120                 125
Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser
    130                 135                 140
Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala
145                 150                 155                 160
Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp
                165                 170                 175
Phe


<210> 27
<211> 407
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR alpha chain constant domain

<400> 27
ctgcagtgta ccagctgcgg gacagcaaga gcagcgacaa gagcgtgtgc ctgttcaccg      60
acttcgacag ccagaccaac gtgtcccaga gcaaggacag cgacgtgtac atcaccgata     120
agtgcgtgct ggacatgcgg agcatggact tcaagagcaa cagcgccgtg gcctggtcca     180
acaagagcga cttcgcctgc gccaacgcct tcaacaacag cattatcccc gaggacacat     240
tcttcccaag ccccgagagc agctgcgacg tgaagctggt ggaaaagagc ttcgagacag     300
acaccaacct gaacttccag aacctcagcg tgatcggctt ccggatcctg ctgctgaagg     360
tggccggctt caacctgctg atgaccctgc ggctgtggtc cagctga                   407

<210> 28
<211> 454
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR beta chain constant domain

<400> 28
gaagatctga acaaagtgtt ccctccagag gtggccgtgt tcgagccttc tgaggccgag      60
atcagccaca cacagaaagc cacactcgtg tgcctggcca ccggcttttt tcccgatcac     120
gtggaactgt cttggtgggt caacggcaaa gaggtgcaca gcggcgtctg taccgatcct     180
cagcctctga aagagcagcc cgctctgaac gactccagat actgcctgag cagcaggctg     240
agagtgtccg ccaccttctg gcagaacccc agaaaccact tcagatgcca ggtgcagttc     300
tacggcctga gcgagaacga tgagtggacc caggatagag ccaagcctgt gacacagatc     360
gtgtctgccg aagcctgggg cagagccgat tgtggcttta cctccgtgtc ctatcagcag     420
ggcgtgctgt ctgccaccat cctgtatgag atcc                                 454

<210> 29
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR1 alpha chain CDR3

<400> 29
Cys Ala Val Arg Arg Gly Asn Asn Asp Met Arg Phe
 1               5                  10

<210> 30
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR2-1 alpha chain CDR3

<400> 30
Cys Ile Val Arg Ala Tyr Ser Gly Tyr Ser Thr Leu Thr Phe
 1               5                  10

<210> 31
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR2-2 alpha chain CDR3

<400> 31
Cys Ala Val Ile Thr Leu Asn Asn Asn Ala Gly Asn Met Leu Thr Phe
 1               5                  10                  15

<210> 32
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR3 alpha chain CDR3

<400> 32
Cys Ala Val Thr Ser Asn Ala Gly Lys Ser Thr Phe
 1               5                  10

<210> 33
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR1 beta chain CDR3

<400> 33
Cys Ala Ser Asn Glu Gly Asn Ser Gly Asn Thr Ile Tyr Phe
 1               5                  10

<210> 34
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR2-1 beta chain CDR3

<400> 34
Cys Ala Ser Gly Ala Arg Gln Ile Pro Tyr Thr Phe
 1               5                  10

<210> 35
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR3 beta chain CDR3

<400> 35
Cys Ala Ser Ser Leu Ser Ala Ala Gly Gly Gly Tyr Gly Tyr Thr Phe
 1               5                  10                  15

<210> 36
<211> 766
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Human BRAF

<400> 36
Met Ala Ala Leu Ser Gly Gly Gly Gly Gly Gly Ala Glu Pro Gly Gln
 1               5                  10                  15
Ala Leu Phe Asn Gly Asp Met Glu Pro Glu Ala Gly Ala Gly Ala Gly
            20                  25                  30
Ala Ala Ala Ser Ser Ala Ala Asp Pro Ala Ile Pro Glu Glu Val Trp
        35                  40                  45
Asn Ile Lys Gln Met Ile Lys Leu Thr Gln Glu His Ile Glu Ala Leu
    50                  55                  60
Leu Asp Lys Phe Gly Gly Glu His Asn Pro Pro Ser Ile Tyr Leu Glu
65                  70                  75                  80
Ala Tyr Glu Glu Tyr Thr Ser Lys Leu Asp Ala Leu Gln Gln Arg Glu
                85                  90                  95
Gln Gln Leu Leu Glu Ser Leu Gly Asn Gly Thr Asp Phe Ser Val Ser
            100                 105                 110
Ser Ser Ala Ser Met Asp Thr Val Thr Ser Ser Ser Ser Ser Ser Leu
        115                 120                 125
Ser Val Leu Pro Ser Ser Leu Ser Val Phe Gln Asn Pro Thr Asp Val
    130                 135                 140
Ala Arg Ser Asn Pro Lys Ser Pro Gln Lys Pro Ile Val Arg Val Phe
145                 150                 155                 160
Leu Pro Asn Lys Gln Arg Thr Val Val Pro Ala Arg Cys Gly Val Thr
                165                 170                 175
Val Arg Asp Ser Leu Lys Lys Ala Leu Met Met Arg Gly Leu Ile Pro
            180                 185                 190
Glu Cys Cys Ala Val Tyr Arg Ile Gln Asp Gly Glu Lys Lys Pro Ile
        195                 200                 205
Gly Trp Asp Thr Asp Ile Ser Trp Leu Thr Gly Glu Glu Leu His Val
    210                 215                 220
Glu Val Leu Glu Asn Val Pro Leu Thr Thr His Asn Phe Val Arg Lys
225                 230                 235                 240
Thr Phe Phe Thr Leu Ala Phe Cys Asp Phe Cys Arg Lys Leu Leu Phe
                245                 250                 255
Gln Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Gln Arg Cys
            260                 265                 270
Ser Thr Glu Val Pro Leu Met Cys Val Asn Tyr Asp Gln Leu Asp Leu
        275                 280                 285
Leu Phe Val Ser Lys Phe Phe Glu His His Pro Ile Pro Gln Glu Glu
    290                 295                 300
Ala Ser Leu Ala Glu Thr Ala Leu Thr Ser Gly Ser Ser Pro Ser Ala
305                 310                 315                 320
Pro Ala Ser Asp Ser Ile Gly Pro Gln Ile Leu Thr Ser Pro Ser Pro
                325                 330                 335
Ser Lys Ser Ile Pro Ile Pro Gln Pro Phe Arg Pro Ala Asp Glu Asp
            340                 345                 350
His Arg Asn Gln Phe Gly Gln Arg Asp Arg Ser Ser Ser Ala Pro Asn
        355                 360                 365
Val His Ile Asn Thr Ile Glu Pro Val Asn Ile Asp Asp Leu Ile Arg
    370                 375                 380
Asp Gln Gly Phe Arg Gly Asp Gly Gly Ser Thr Thr Gly Leu Ser Ala
385                 390                 395                 400
Thr Pro Pro Ala Ser Leu Pro Gly Ser Leu Thr Asn Val Lys Ala Leu
                405                 410                 415
Gln Lys Ser Pro Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser
            420                 425                 430
Glu Asp Arg Asn Arg Met Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp
        435                 440                 445
Asp Trp Glu Ile Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly
    450                 455                 460
Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val
465                 470                 475                 480
Ala Val Lys Met Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu Gln
                485                 490                 495
Ala Phe Lys Asn Glu Val Gly Val Leu Arg Lys Thr Arg His Val Asn
            500                 505                 510
Ile Leu Leu Phe Met Gly Tyr Ser Thr Lys Pro Gln Leu Ala Ile Val
        515                 520                 525
Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Ile Ile
    530                 535                 540
Glu Thr Lys Phe Glu Met Ile Lys Leu Ile Asp Ile Ala Arg Gln Thr
545                 550                 555                 560
Ala Gln Gly Met Asp Tyr Leu His Ala Lys Ser Ile Ile His Arg Asp
                565                 570                 575
Leu Lys Ser Asn Asn Ile Phe Leu His Glu Asp Leu Thr Val Lys Ile
            580                 585                 590
Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp Ser Gly Ser His
        595                 600                 605
Gln Phe Glu Gln Leu Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val
    610                 615                 620
Ile Arg Met Gln Asp Lys Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr
625                 630                 635                 640
Ala Phe Gly Ile Val Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr
                645                 650                 655
Ser Asn Ile Asn Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly
            660                 665                 670
Tyr Leu Ser Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala
        675                 680                 685
Met Lys Arg Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg
    690                 695                 700
Pro Leu Phe Pro Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser
705                 710                 715                 720
Leu Pro Lys Ile His Arg Ser Ala Ser Glu Pro Ser Leu Asn Arg Ala
                725                 730                 735
Gly Phe Gln Thr Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser Pro Lys
            740                 745                 750
Thr Pro Ile Gln Ala Gly Gly Tyr Gly Ala Phe Pro Val His
        755                 760                 765

<210> 37
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence 27-mer BRAFV600E peptide

<400> 37
Asp Leu Thr Val Lys Ile Gly Asp Phe Gly Leu Ala Thr Glu Lys Ser
 1               5                  10                  15
Arg Trp Ser Gly Ser His Gln Phe Glu Gln Leu
            20                  25

<210> 38
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence 20-mer BRAFV600E peptide

<400> 38
Asp Leu Thr Val Lys Ile Gly Asp Phe Gly Leu Ala Thr Glu Lys Ser
 1               5                  10                  15
Arg Trp Ser Gly
            20

<210> 39
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence 20-mer BRAFV600E peptide

<400> 39
Asp Phe Gly Leu Ala Thr Glu Lys Ser Arg Trp Ser Gly Ser His Gln
 1               5                  10                  15
Phe Glu Gln Leu
            20

<210> 40
<211> 266
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HLADRB1

<400> 40
Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr
 1               5                  10                  15
Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr
            20                  25                  30
Arg Pro Arg Phe Leu Trp Gln Leu Lys Phe Glu Cys His Phe Phe Asn
        35                  40                  45
Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile Tyr Asn Gln Glu
    50                  55                  60
Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr
65                  70                  75                  80
Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu
                85                  90                  95
Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr
            100                 105                 110
Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Glu Pro Lys Val
        115                 120                 125
Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu
    130                 135                 140
Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp
145                 150                 155                 160
Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu
                165                 170                 175
Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr
            180                 185                 190
Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser
        195                 200                 205
Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala
    210                 215                 220
Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu
225                 230                 235                 240
Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His
                245                 250                 255
Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser
            260                 265

<210> 41
<211> 261
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HLADQB10302

<400> 41
Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Val Ala
 1               5                  10                  15
Thr Val Thr Leu Met Leu Ala Met Leu Ser Thr Pro Val Ala Glu Gly
            20                  25                  30
Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Gly Met Cys Tyr
        35                  40                  45
Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Thr Arg Tyr Ile Tyr
    50                  55                  60
Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg
65                  70                  75                  80
Ala Val Thr Pro Leu Gly Pro Pro Ala Ala Glu Tyr Trp Asn Ser Gln
                85                  90                  95
Lys Glu Val Leu Glu Arg Thr Arg Ala Glu Leu Asp Thr Val Cys Arg
            100                 105                 110
His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu
        115                 120                 125
Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His
    130                 135                 140
Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys
145                 150                 155                 160
Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Thr Gly Val Val Ser
                165                 170                 175
Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met
            180                 185                 190
Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu
        195                 200                 205
His Pro Ser Leu Gln Asn Pro Ile Ile Val Glu Trp Arg Ala Gln Ser
    210                 215                 220
Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu
225                 230                 235                 240
Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile His His Arg Ser Gln
                245                 250                 255
Lys Gly Leu Leu His
            260

<210> 42
<211> 255
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HLADQA103

<400> 42
Met Ile Leu Asn Lys Ala Leu Met Leu Gly Ala Leu Ala Leu Thr Thr
 1               5                  10                  15
Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala
            20                  25                  30
Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Tyr
        35                  40                  45
Ser His Glu Phe Asp Gly Asp Glu Glu Phe Tyr Val Asp Leu Glu Arg
    50                  55                  60
Lys Glu Thr Val Trp Gln Leu Pro Leu Phe Arg Arg Phe Arg Arg Phe
65                  70                  75                  80
Asp Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Leu Lys His Asn Leu
                85                  90                  95
Asn Ile Val Ile Lys Arg Ser Asn Ser Thr Ala Ala Thr Asn Glu Val
            100                 105                 110
Pro Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro
        115                 120                 125
Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn
    130                 135                 140
Ile Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu
145                 150                 155                 160
Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr
                165                 170                 175
Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu
            180                 185                 190
His Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Pro Glu Ile
        195                 200                 205
Pro Thr Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly
    210                 215                 220
Leu Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Leu Ile Ile
225                 230                 235                 240
Arg Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu
                245                 250                 255

<210> 43
<211> 538
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HLADQB10302-P2A-HLADQBA103

<400> 43
Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Val Ala
 1               5                  10                  15
Thr Val Thr Leu Met Leu Ala Met Leu Ser Thr Pro Val Ala Glu Gly
            20                  25                  30
Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Gly Met Cys Tyr
        35                  40                  45
Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Thr Arg Tyr Ile Tyr
    50                  55                  60
Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg
65                  70                  75                  80
Ala Val Thr Pro Leu Gly Pro Pro Ala Ala Glu Tyr Trp Asn Ser Gln
                85                  90                  95
Lys Glu Val Leu Glu Arg Thr Arg Ala Glu Leu Asp Thr Val Cys Arg
            100                 105                 110
His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu
        115                 120                 125
Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His
    130                 135                 140
Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys
145                 150                 155                 160
Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Thr Gly Val Val Ser
                165                 170                 175
Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met
            180                 185                 190
Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu
        195                 200                 205
His Pro Ser Leu Gln Asn Pro Ile Ile Val Glu Trp Arg Ala Gln Ser
    210                 215                 220
Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu
225                 230                 235                 240
Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile His His Arg Ser Gln
                245                 250                 255
Lys Gly Leu Leu His Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys
            260                 265                 270
Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ile Leu Asn Lys
        275                 280                 285
Ala Leu Met Leu Gly Ala Leu Ala Leu Thr Thr Val Met Ser Pro Cys
    290                 295                 300
Gly Gly Glu Asp Ile Val Ala Asp His Val Ala Ser Tyr Gly Val Asn
305                 310                 315                 320
Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Tyr Ser His Glu Phe Asp
                325                 330                 335
Gly Asp Glu Glu Phe Tyr Val Asp Leu Glu Arg Lys Glu Thr Val Trp
            340                 345                 350
Gln Leu Pro Leu Phe Arg Arg Phe Arg Arg Phe Asp Pro Gln Phe Ala
        355                 360                 365
Leu Thr Asn Ile Ala Val Leu Lys His Asn Leu Asn Ile Val Ile Lys
    370                 375                 380
Arg Ser Asn Ser Thr Ala Ala Thr Asn Glu Val Pro Glu Val Thr Val
385                 390                 395                 400
Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro Asn Thr Leu Ile Cys
                405                 410                 415
Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn Ile Thr Trp Leu Ser
            420                 425                 430
Asn Gly His Ser Val Thr Glu Gly Val Ser Glu Thr Ser Phe Leu Ser
        435                 440                 445
Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr Leu Thr Phe Leu Pro
    450                 455                 460
Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu His Trp Gly Leu Asp
465                 470                 475                 480
Glu Pro Leu Leu Lys His Trp Glu Pro Glu Ile Pro Thr Pro Met Ser
                485                 490                 495
Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly Leu Ser Val Gly Leu
            500                 505                 510
Val Gly Ile Val Val Gly Thr Val Leu Ile Ile Arg Gly Leu Arg Ser
        515                 520                 525
Val Gly Ala Ser Arg His Gln Gly Pro Leu
    530                 535

<210> 44
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Porcine teschovirus-1 2A (P2A)
      peptide

<400> 44
ggcagcggcg ccaccaactt tagcctgctg aaacaggctg gcgacgtgga agagaacccc      60
ggacct                                                                 66

<210> 45
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Porcine teschovirus-1 2A (P2A)
      peptide

<400> 45
ggctctggcg ccaccaactt tagcctgctg aaacaggctg gcgacgtgga agagaacccc      60
ggacct                                                                 66

<210> 46
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Thoseaasigna virus 2A (T2A)
      peptide

<400> 46
ggaagcggag agggcagagg aagtctgcta acatgcggtg acgtcgagga gaatcctgga      60
cct                                                                    63

<210> 47
<211> 69
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Equine rhinitis A virus (ERAV)
      2A (E2A) peptide

<400> 47
ggaagcggac agtgtactaa ttatgctctc ttgaaattgg ctggagatgt tgagagcaac      60
cctggacct                                                              69

<210> 48
<211> 75
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Foot-and-Mouth disease virus 2A
      (F2A) peptide

<400> 48
ggaagcggag tgaaacagac tttgaatttt gaccttctca agttggcggg agacgtggag      60
tccaaccctg gacct                                                       75

<210> 49
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Porcine teschovirus-1 2A (P2A)

<400> 49
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val
 1               5                  10                  15
Glu Glu Asn Pro Gly Pro
            20

<210> 50
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Thoseaasigna virus 2A (T2A)
      peptide

<400> 50
Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp
 1               5                  10                  15
Val Glu Glu Asn Pro Gly Pro Arg
            20

<210> 51
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Equine rhinitis A virus (ERAV)
      2A (E2A) peptide

<400> 51
Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser
 1               5                  10                  15
Asn Pro Gly Pro
            20

<210> 52
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Foot-and-Mouth disease virus 2A
      (F2A) peptide

<400> 52
Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala
 1               5                  10                  15
Gly Asp Val Glu Ser Asn Pro Gly Pro
            20                  25

<210> 53
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Glycine-Serine linker

<400> 53
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15

<210> 54
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Glycine-Serine linker

<400> 54
Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly
 1               5                  10                  15
Ser Ser


<210> 55
<211> 271
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR1 alpha chain (full-length)

<400> 55
Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp
 1               5                  10                  15
Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val
            20                  25                  30
Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala
        35                  40                  45
Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr
    50                  55                  60
Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg
65                  70                  75                  80
Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile
                85                  90                  95
Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Arg
            100                 105                 110
Arg Gly Asn Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val
        115                 120                 125
Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp
    130                 135                 140
Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser
145                 150                 155                 160
Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp
                165                 170                 175
Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala
            180                 185                 190
Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn
        195                 200                 205
Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser
    210                 215                 220
Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu
225                 230                 235                 240
Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys
                245                 250                 255
Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
            260                 265                 270

<210> 56
<211> 269
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR2-1 alpha chain
      (full-length)

<400> 56
Met Arg Leu Val Ala Arg Val Thr Val Phe Leu Thr Phe Gly Thr Ile
 1               5                  10                  15
Ile Asp Ala Lys Thr Thr Gln Pro Thr Ser Met Asp Cys Ala Glu Gly
            20                  25                  30
Arg Ala Ala Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu
        35                  40                  45
Tyr Val Tyr Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile
    50                  55                  60
Ile His Gly Leu Lys Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile
65                  70                  75                  80
Ile Thr Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr
                85                  90                  95
Leu Arg Asp Thr Ala Val Tyr Tyr Cys Ile Val Arg Ala Tyr Ser Gly
            100                 105                 110
Tyr Ser Thr Leu Thr Phe Gly Lys Gly Thr Met Leu Leu Val Ser Pro
        115                 120                 125
Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys
    130                 135                 140
Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr
145                 150                 155                 160
Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys
                165                 170                 175
Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala
            180                 185                 190
Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser
        195                 200                 205
Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp
    210                 215                 220
Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe
225                 230                 235                 240
Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala
                245                 250                 255
Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
            260                 265

<210> 57
<211> 276
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR2-2 alpha chain
      (full-length)

<400> 57
Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser
 1               5                  10                  15
Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu
            20                  25                  30
Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp
        35                  40                  45
Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser
    50                  55                  60
Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly
65                  70                  75                  80
Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu
                85                  90                  95
Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val
            100                 105                 110
Ile Thr Leu Asn Asn Asn Ala Gly Asn Met Leu Thr Phe Gly Gly Gly
        115                 120                 125
Thr Arg Leu Met Val Lys Pro His Ile Gln Asn Pro Asp Pro Ala Val
    130                 135                 140
Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe
145                 150                 155                 160
Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp
                165                 170                 175
Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe
            180                 185                 190
Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys
        195                 200                 205
Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro
    210                 215                 220
Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu
225                 230                 235                 240
Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg
                245                 250                 255
Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg
            260                 265                 270
Leu Trp Ser Ser
        275

<210> 58
<211> 272
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR3 alpha chain (full-length)

<400> 58
Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser
 1               5                  10                  15
Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu
            20                  25                  30
Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp
        35                  40                  45
Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser
    50                  55                  60
Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly
65                  70                  75                  80
Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu
                85                  90                  95
Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val
            100                 105                 110
Thr Ser Asn Ala Gly Lys Ser Thr Phe Gly Asp Gly Thr Thr Leu Thr
        115                 120                 125
Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg
    130                 135                 140
Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp
145                 150                 155                 160
Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr
                165                 170                 175
Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser
            180                 185                 190
Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe
        195                 200                 205
Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser
    210                 215                 220
Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn
225                 230                 235                 240
Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu
                245                 250                 255
Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
            260                 265                 270

<210> 59
<211> 309
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence  TCR1 alpha chain (full-length)

<400> 59
Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val
 1               5                  10                  15
Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys
            20                  25                  30
Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His
        35                  40                  45
Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile
                85                  90                  95
Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser
            100                 105                 110
Asn Glu Gly Asn Ser Gly Asn Thr Ile Tyr Phe Gly Glu Gly Ser Trp
        115                 120                 125
Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala
    130                 135                 140
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
145                 150                 155                 160
Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser
                165                 170                 175
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro
            180                 185                 190
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
        195                 200                 205
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
    210                 215                 220
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
225                 230                 235                 240
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                245                 250                 255
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln
            260                 265                 270
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
        275                 280                 285
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
    290                 295                 300
Lys Arg Lys Asp Phe
305

<210> 60
<211> 307
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence  TCR2-1 and 2-2 beta chain
      (full-length)

<400> 60
Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val
 1               5                  10                  15
Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys
            20                  25                  30
Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His
        35                  40                  45
Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile
                85                  90                  95
Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser
            100                 105                 110
Gly Ala Arg Gln Ile Pro Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr
        115                 120                 125
Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe
    130                 135                 140
Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val
145                 150                 155                 160
Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp
                165                 170                 175
Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro
            180                 185                 190
Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser
        195                 200                 205
Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe
    210                 215                 220
Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr
225                 230                 235                 240
Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp
                245                 250                 255
Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val
            260                 265                 270
Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu
        275                 280                 285
Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg
    290                 295                 300
Lys Asp Phe
305

<210> 61
<211> 317
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence  TCR3 beta chain (full-length)

<400> 61
Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val
 1               5                  10                  15
Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys
            20                  25                  30
Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His
        35                  40                  45
Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile
                85                  90                  95
Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Leu Ser Ala Ala Gly Gly Gly Tyr Gly Tyr Thr Phe Asn Tyr Gly
        115                 120                 125
Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr Val Val Glu Asp Leu Asn
    130                 135                 140
Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu
145                 150                 155                 160
Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe
                165                 170                 175
Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val
            180                 185                 190
His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala
        195                 200                 205
Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala
    210                 215                 220
Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe
225                 230                 235                 240
Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro
                245                 250                 255
Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly
            260                 265                 270
Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu
        275                 280                 285
Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser
    290                 295                 300
Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe
305                 310                 315

<210> 62
<211> 816
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR1 alpha chain (full-length)

<400> 62
atggaaacac tgctgggcct gctgatcctg tggctgcaac tgcaatgggt gtccagcaag      60
caagaagtga ctcagatccc tgccgctctg tctgtgcctg agggcgaaaa cctggtcctg     120
aactgcagct tcaccgacag cgccatctac aacctgcagt ggttcaggca ggatccaggc     180
aagggcctga catccctgct gctgattcag agcagccaga gagagcagac cagcggcaga     240
ctgaatgcca gcctggataa gtcctccggc agaagcaccc tgtatatcgc cgcttctcag     300
ccaggcgata gcgccacata tctgtgtgcc gttcggagag gcaacaacga catgagattc     360
ggagccggca ccagactgac cgtgaagccc aacattcaga accccgatcc tgcagtgtac     420
cagctgcggg acagcaagag cagcgacaag agcgtgtgcc tgttcaccga cttcgacagc     480
cagaccaacg tgtcccagag caaggacagc gacgtgtaca tcaccgataa gtgcgtgctg     540
gacatgcgga gcatggactt caagagcaac agcgccgtgg cctggtccaa caagagcgac     600
ttcgcctgcg ccaacgcctt caacaacagc attatccccg aggacacatt cttcccaagc     660
cccgagagca gctgcgacgt gaagctggtg gaaaagagct tcgagacaga caccaacctg     720
aacttccaga acctcagcgt gatcggcttc cggatcctgc tgctgaaggt ggccggcttc     780
aacctgctga tgaccctgcg gctgtggtcc agctga                               816

<210> 63
<211> 810
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence  TCR2-1 alpha chain
      (full-length)

<400> 63
atgagactgg tggccagagt gacagtgttc ctgaccttcg gcaccatcat cgacgccaag      60
accacacagc ccaccagcat ggattgtgcc gagggcagag ctgccaacct gccttgtaat     120
cacagcacca tcagcggcaa cgagtacgtg tactggtaca ggcagatcca ctctcagggc     180
cctcagtaca tcatccacgg cctgaagaac aacgagacaa acgagatggc ctctctgatc     240
atcaccgagg accgcaagag cagcaccctg attctgcctc acgccacact gagagacacc     300
gccgtgtact actgtatcgt gcgggcctac agcggctaca gcacactgac atttggcaag     360
ggcaccatgc tgctcgtgtc cccagacatt cagaaccccg atcctgcagt gtaccagctg     420
cgggacagca agagcagcga caagagcgtg tgcctgttca ccgacttcga cagccagacc     480
aacgtgtccc agagcaagga cagcgacgtg tacatcaccg ataagtgcgt gctggacatg     540
cggagcatgg acttcaagag caacagcgcc gtggcctggt ccaacaagag cgacttcgcc     600
tgcgccaacg ccttcaacaa cagcattatc cccgaggaca cattcttccc aagccccgag     660
agcagctgcg acgtgaagct ggtggaaaag agcttcgaga cagacaccaa cctgaacttc     720
cagaacctca gcgtgatcgg cttccggatc ctgctgctga aggtggccgg cttcaacctg     780
ctgatgaccc tgcggctgtg gtccagctga                                      810

<210> 64
<211> 831
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence  TCR2-2 alpha chain
      (full-length)

<400> 64
atgaagtccc tgagagtgct gctggtcatc ctgtggctgc agctgtcttg ggtctggtcc      60
cagcagaaag aggtggaaca gaacagcggc cctctgtctg ttcctgaagg cgctatcgcc     120
tctctgaatt gcacctacag cgacagaggc agccagagct tcttctggta tcggcagtac     180
agcggcaaga gccccgagct gatcatgttc atctacagca acggcgacaa agaggacggc     240
cggtttacag cccagctgaa caaggccagc cagtacgtgt cactgctgat cagagacagc     300
cagcctagcg acagcgccac ctatctgtgt gccgtgatca ccctgaacaa caacgccggc     360
aacatgctga cctttggcgg cggaacacgg ctgatggtta agccccacat tcagaacccc     420
gatcctgcag tgtaccagct gcgggacagc aagagcagcg acaagagcgt gtgcctgttc     480
accgacttcg acagccagac caacgtgtcc cagagcaagg acagcgacgt gtacatcacc     540
gataagtgcg tgctggacat gcggagcatg gacttcaaga gcaacagcgc cgtggcctgg     600
tccaacaaga gcgacttcgc ctgcgccaac gccttcaaca acagcattat ccccgaggac     660
acattcttcc caagccccga gagcagctgc gacgtgaagc tggtggaaaa gagcttcgag     720
acagacacca acctgaactt ccagaacctc agcgtgatcg gcttccggat cctgctgctg     780
aaggtggccg gcttcaacct gctgatgacc ctgcggctgt ggtccagctg a              831

<210> 65
<211> 819
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR3 alpha chain (full-length)

<400> 65
atgaagtccc tgagagtgct gctggtcatc ctgtggctgc agctgtcttg ggtctggtcc      60
cagcagaaag aggtggaaca gaacagcggc cctctgtccg ttcctgaagg cgccattgct     120
agcctgaatt gcacctacag cgaccggggc agccagagct tcttctggta taggcagtac     180
agcggcaaga gccccgagct gatcatgttc atctacagca acggcgacaa agaggacggc     240
cggtttacag cccagctgaa caaggccagc cagtacgtgt cactgctgat cagagacagc     300
cagcctagcg acagcgccac ctatctgtgt gccgtgacaa gcaatgccgg caagtccaca     360
tttggcgacg gcacaaccct gaccgtgaag cccaacattc agaaccccga tcctgcagtg     420
taccagctgc gggacagcaa gagcagcgac aagagcgtgt gcctgttcac cgacttcgac     480
agccagacca acgtgtccca gagcaaggac agcgacgtgt acatcaccga taagtgcgtg     540
ctggacatgc ggagcatgga cttcaagagc aacagcgccg tggcctggtc caacaagagc     600
gacttcgcct gcgccaacgc cttcaacaac agcattatcc ccgaggacac attcttccca     660
agccccgaga gcagctgcga cgtgaagctg gtggaaaaga gcttcgagac agacaccaac     720
ctgaacttcc agaacctcag cgtgatcggc ttccggatcc tgctgctgaa ggtggccggc     780
ttcaacctgc tgatgaccct gcggctgtgg tccagctga                            819

<210> 66
<211> 927
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR1 beta chain (full-length)

<400> 66
atgggaatta gactgctgtg cagagtggcc ttctgcttcc tggctgttgg cctggtggac      60
gtgaaagtga cccagagcag cagatacctg gtcaagagaa ccggcgagaa ggtgttcctg     120
gaatgcgtgc aggacatgga ccacgagaat atgttctggt acagacagga ccccggcctg     180
ggcctgagac tgatctactt cagctacgac gtgaagatga aggaaaaggg cgacatcccc     240
gagggctaca gcgtgtccag agagaagaaa gagcggttca gcctgatcct ggaaagcgcc     300
agcaccaacc agaccagcat gtacctgtgc gccagcaacg agggcaatag cggcaacacc     360
atctacttcg gcgaaggcag ctggctgacc gtggtggaag atctgaacaa agtgttccct     420
ccagaggtgg ccgtgttcga gccttctgag gccgagatca gccacacaca gaaagccaca     480
ctcgtgtgcc tggccaccgg cttttttccc gatcacgtgg aactgtcttg gtgggtcaac     540
ggcaaagagg tgcacagcgg cgtctgtacc gatcctcagc ctctgaaaga gcagcccgct     600
ctgaacgact ccagatactg cctgagcagc aggctgagag tgtccgccac cttctggcag     660
aaccccagaa accacttcag atgccaggtg cagttctacg gcctgagcga gaacgatgag     720
tggacccagg atagagccaa gcctgtgaca cagatcgtgt ctgccgaagc ctggggcaga     780
gccgattgtg gctttacctc cgtgtcctat cagcagggcg tgctgtctgc caccatcctg     840
tatgagatcc tgctgggcaa agccactctg tacgccgtgc tggtgtctgc cctggtgctg     900
atggccatgg tcaagcggaa ggatttt                                         927

<210> 67
<211> 921
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR2-1 and 2-2  beta chain
      (full-length)

<400> 67
atgggaatta gactgctgtg cagagtggcc ttctgcttcc tggctgttgg cctggtggac      60
gtgaaagtga cccagagcag cagatacctg gtcaagagaa ccggcgagaa ggtgttcctg     120
gaatgcgtgc aggacatgga ccacgagaat atgttctggt acagacagga ccccggcctg     180
ggcctgagac tgatctactt cagctacgac gtgaagatga aggaaaaggg cgacatcccc     240
gagggctaca gcgtgtccag agagaagaaa gagcggttca gcctgatcct ggaaagcgcc     300
agcaccaacc agaccagcat gtacctgtgt gccagcggcg ccagacagat cccttacaca     360
tttggctccg gcaccagact gaccgtggtg gaagatctga acaaagtgtt ccctccagag     420
gtggccgtgt tcgagccttc tgaggccgag atcagccaca cacagaaagc cacactcgtg     480
tgcctggcca ccggcttttt tcccgatcac gtggaactgt cttggtgggt caacggcaaa     540
gaggtgcaca gcggcgtctg taccgatcct cagcctctga aagagcagcc cgctctgaac     600
gactccagat actgcctgag cagcaggctg agagtgtccg ccaccttctg gcagaacccc     660
agaaaccact tcagatgcca ggtgcagttc tacggcctga gcgagaacga tgagtggacc     720
caggatagag ccaagcctgt gacacagatc gtgtctgccg aagcctgggg cagagccgat     780
tgtggcttta cctccgtgtc ctatcagcag ggcgtgctgt ctgccaccat cctgtatgag     840
atcctgctgg gcaaagccac tctgtacgcc gtgctggtgt ctgccctggt gctgatggcc     900
atggtcaagc ggaaggattt t                                               921

<210> 68
<211> 951
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR3 beta chain (full-length)

<400> 68
atgggaatta gactgctgtg cagagtggcc ttctgcttcc tggctgttgg cctggtggac      60
gtgaaagtga cccagagcag cagatacctg gtcaagagaa ccggcgagaa ggtgttcctg     120
gaatgcgtgc aggacatgga ccacgagaat atgttctggt acagacagga ccccggcctg     180
ggcctgagac tgatctactt cagctacgac gtgaagatga aggaaaaggg cgacatcccc     240
gagggctaca gcgtgtccag agagaagaaa gagcggttca gcctgatcct ggaaagcgcc     300
agcaccaacc agaccagcat gtacctgtgt gccagctctc tgtctgctgc cggcggaggc     360
tatggctaca ccttcaatta cggctacaca ttcggcagcg gcaccagact gaccgtggtg     420
gaagatctga acaaagtgtt ccctccagag gtggccgtgt tcgagccttc tgaggccgag     480
atcagccaca cacagaaagc cacactcgtg tgcctggcca ccggcttttt tcccgatcac     540
gtggaactgt cttggtgggt caacggcaaa gaggtgcaca gcggcgtctg taccgatcct     600
cagcctctga aagagcagcc cgctctgaac gactccagat actgcctgag cagcaggctg     660
agagtgtccg ccaccttctg gcagaacccc agaaaccact tcagatgcca ggtgcagttc     720
tacggcctga gcgagaacga tgagtggacc caggatagag ccaagcctgt gacacagatc     780
gtgtctgccg aagcctgggg cagagccgat tgtggcttta cctccgtgtc ctatcagcag     840
ggcgtgctgt ctgccaccat cctgtatgag atcctgctgg gcaaagccac tctgtacgcc     900
gtgctggtgt ctgccctggt gctgatggcc atggtcaagc ggaaggattt t              951

<210> 69
<211> 602
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR1 (beta-P2A-alpha)

<400> 69
Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val
 1               5                  10                  15
Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys
            20                  25                  30
Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His
        35                  40                  45
Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile
                85                  90                  95
Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser
            100                 105                 110
Asn Glu Gly Asn Ser Gly Asn Thr Ile Tyr Phe Gly Glu Gly Ser Trp
        115                 120                 125
Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala
    130                 135                 140
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
145                 150                 155                 160
Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser
                165                 170                 175
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro
            180                 185                 190
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
        195                 200                 205
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
    210                 215                 220
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
225                 230                 235                 240
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                245                 250                 255
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln
            260                 265                 270
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
        275                 280                 285
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
    290                 295                 300
Lys Arg Lys Asp Phe Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys
305                 310                 315                 320
Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Thr Leu Leu
                325                 330                 335
Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp Val Ser Ser Lys Gln
            340                 345                 350
Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val Pro Glu Gly Glu Asn
        355                 360                 365
Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala Ile Tyr Asn Leu Gln
    370                 375                 380
Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr Ser Leu Leu Leu Ile
385                 390                 395                 400
Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg Leu Asn Ala Ser Leu
                405                 410                 415
Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile Ala Ala Ser Gln Pro
            420                 425                 430
Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Arg Arg Gly Asn Asn Asp
        435                 440                 445
Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Asn Ile Gln
    450                 455                 460
Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp
465                 470                 475                 480
Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser
                485                 490                 495
Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp
            500                 505                 510
Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn
        515                 520                 525
Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro
    530                 535                 540
Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu
545                 550                 555                 560
Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu
                565                 570                 575
Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn
            580                 585                 590
Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
        595                 600

<210> 70
<211> 598
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR2-1 (beta-P2A-alpha)

<400> 70
Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val
 1               5                  10                  15
Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys
            20                  25                  30
Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His
        35                  40                  45
Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile
                85                  90                  95
Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser
            100                 105                 110
Gly Ala Arg Gln Ile Pro Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr
        115                 120                 125
Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe
    130                 135                 140
Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val
145                 150                 155                 160
Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp
                165                 170                 175
Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro
            180                 185                 190
Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser
        195                 200                 205
Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe
    210                 215                 220
Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr
225                 230                 235                 240
Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp
                245                 250                 255
Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val
            260                 265                 270
Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu
        275                 280                 285
Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg
    290                 295                 300
Lys Asp Phe Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala
305                 310                 315                 320
Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg Leu Val Ala Arg Val
                325                 330                 335
Thr Val Phe Leu Thr Phe Gly Thr Ile Ile Asp Ala Lys Thr Thr Gln
            340                 345                 350
Pro Thr Ser Met Asp Cys Ala Glu Gly Arg Ala Ala Asn Leu Pro Cys
        355                 360                 365
Asn His Ser Thr Ile Ser Gly Asn Glu Tyr Val Tyr Trp Tyr Arg Gln
    370                 375                 380
Ile His Ser Gln Gly Pro Gln Tyr Ile Ile His Gly Leu Lys Asn Asn
385                 390                 395                 400
Glu Thr Asn Glu Met Ala Ser Leu Ile Ile Thr Glu Asp Arg Lys Ser
                405                 410                 415
Ser Thr Leu Ile Leu Pro His Ala Thr Leu Arg Asp Thr Ala Val Tyr
            420                 425                 430
Tyr Cys Ile Val Arg Ala Tyr Ser Gly Tyr Ser Thr Leu Thr Phe Gly
        435                 440                 445
Lys Gly Thr Met Leu Leu Val Ser Pro Asp Ile Gln Asn Pro Asp Pro
    450                 455                 460
Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys
465                 470                 475                 480
Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp
                485                 490                 495
Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met
            500                 505                 510
Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe
        515                 520                 525
Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe
    530                 535                 540
Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser
545                 550                 555                 560
Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly
                565                 570                 575
Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr
            580                 585                 590
Leu Arg Leu Trp Ser Ser
        595

<210> 71
<211> 605
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR2-2 amino acid
      (beta-P2A-alpha)

<400> 71
Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val
 1               5                  10                  15
Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys
            20                  25                  30
Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His
        35                  40                  45
Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile
                85                  90                  95
Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser
            100                 105                 110
Gly Ala Arg Gln Ile Pro Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr
        115                 120                 125
Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe
    130                 135                 140
Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val
145                 150                 155                 160
Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp
                165                 170                 175
Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro
            180                 185                 190
Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser
        195                 200                 205
Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe
    210                 215                 220
Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr
225                 230                 235                 240
Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp
                245                 250                 255
Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val
            260                 265                 270
Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu
        275                 280                 285
Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg
    290                 295                 300
Lys Asp Phe Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala
305                 310                 315                 320
Gly Asp Val Glu Glu Asn Pro Gly Pro Met Lys Ser Leu Arg Val Leu
                325                 330                 335
Leu Val Ile Leu Trp Leu Gln Leu Ser Trp Val Trp Ser Gln Gln Lys
            340                 345                 350
Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly Ala Ile
        355                 360                 365
Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser Phe Phe
    370                 375                 380
Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met Phe Ile
385                 390                 395                 400
Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn
                405                 410                 415
Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser
            420                 425                 430
Asp Ser Ala Thr Tyr Leu Cys Ala Val Ile Thr Leu Asn Asn Asn Ala
        435                 440                 445
Gly Asn Met Leu Thr Phe Gly Gly Gly Thr Arg Leu Met Val Lys Pro
    450                 455                 460
His Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys
465                 470                 475                 480
Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr
                485                 490                 495
Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys
            500                 505                 510
Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala
        515                 520                 525
Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser
    530                 535                 540
Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp
545                 550                 555                 560
Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe
                565                 570                 575
Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala
            580                 585                 590
Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
        595                 600                 605

<210> 72
<211> 476
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR3 amino acid
      (beta-P2A-alpha)

<400> 72
Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val
 1               5                  10                  15
Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys
            20                  25                  30
Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His
        35                  40                  45
Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile
                85                  90                  95
Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Leu Ser Ala Ala Gly Gly Gly Tyr Gly Tyr Thr Phe Asn Tyr Gly
        115                 120                 125
Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr Val Val Glu Asp Leu Asn
    130                 135                 140
Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu
145                 150                 155                 160
Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe
                165                 170                 175
Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val
            180                 185                 190
His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala
        195                 200                 205
Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala
    210                 215                 220
Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe
225                 230                 235                 240
Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro
                245                 250                 255
Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly
            260                 265                 270
Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu
        275                 280                 285
Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser
    290                 295                 300
Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe Gly Ser Gly
305                 310                 315                 320
Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn
                325                 330                 335
Pro Gly Pro Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu
            340                 345                 350
Gln Leu Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser
        355                 360                 365
Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr
    370                 375                 380
Tyr Ser Asp Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser
385                 390                 395                 400
Gly Lys Ser Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys
                405                 410                 415
Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val
            420                 425                 430
Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu
        435                 440                 445
Cys Ala Val Thr Ser Asn Ala Gly Lys Ser Thr Phe Gly Asp Gly Thr
    450                 455                 460
Thr Leu Thr Val Lys Pro Asn Ile Gln Asn Pro Asp
465                 470                 475

<210> 73
<211> 1809
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR1 (beta-P2A-alpha)

<400> 73
atgggaatta gactgctgtg cagagtggcc ttctgcttcc tggctgttgg cctggtggac      60
gtgaaagtga cccagagcag cagatacctg gtcaagagaa ccggcgagaa ggtgttcctg     120
gaatgcgtgc aggacatgga ccacgagaat atgttctggt acagacagga ccccggcctg     180
ggcctgagac tgatctactt cagctacgac gtgaagatga aggaaaaggg cgacatcccc     240
gagggctaca gcgtgtccag agagaagaaa gagcggttca gcctgatcct ggaaagcgcc     300
agcaccaacc agaccagcat gtacctgtgc gccagcaacg agggcaatag cggcaacacc     360
atctacttcg gcgaaggcag ctggctgacc gtggtggaag atctgaacaa agtgttccct     420
ccagaggtgg ccgtgttcga gccttctgag gccgagatca gccacacaca gaaagccaca     480
ctcgtgtgcc tggccaccgg cttttttccc gatcacgtgg aactgtcttg gtgggtcaac     540
ggcaaagagg tgcacagcgg cgtctgtacc gatcctcagc ctctgaaaga gcagcccgct     600
ctgaacgact ccagatactg cctgagcagc aggctgagag tgtccgccac cttctggcag     660
aaccccagaa accacttcag atgccaggtg cagttctacg gcctgagcga gaacgatgag     720
tggacccagg atagagccaa gcctgtgaca cagatcgtgt ctgccgaagc ctggggcaga     780
gccgattgtg gctttacctc cgtgtcctat cagcagggcg tgctgtctgc caccatcctg     840
tatgagatcc tgctgggcaa agccactctg tacgccgtgc tggtgtctgc cctggtgctg     900
atggccatgg tcaagcggaa ggattttggc agcggcgcca ccaactttag cctgctgaaa     960
caggctggcg acgtggaaga gaaccccgga cctatggaaa cactgctggg cctgctgatc    1020
ctgtggctgc aactgcaatg ggtgtccagc aagcaagaag tgactcagat ccctgccgct    1080
ctgtctgtgc ctgagggcga aaacctggtc ctgaactgca gcttcaccga cagcgccatc    1140
tacaacctgc agtggttcag gcaggatcca ggcaagggcc tgacatccct gctgctgatt    1200
cagagcagcc agagagagca gaccagcggc agactgaatg ccagcctgga taagtcctcc    1260
ggcagaagca ccctgtatat cgccgcttct cagccaggcg atagcgccac atatctgtgt    1320
gccgttcgga gaggcaacaa cgacatgaga ttcggagccg gcaccagact gaccgtgaag    1380
cccaacattc agaaccccga tcctgcagtg taccagctgc gggacagcaa gagcagcgac    1440
aagagcgtgt gcctgttcac cgacttcgac agccagacca acgtgtccca gagcaaggac    1500
agcgacgtgt acatcaccga taagtgcgtg ctggacatgc ggagcatgga cttcaagagc    1560
aacagcgccg tggcctggtc caacaagagc gacttcgcct gcgccaacgc cttcaacaac    1620
agcattatcc ccgaggacac attcttccca agccccgaga gcagctgcga cgtgaagctg    1680
gtggaaaaga gcttcgagac agacaccaac ctgaacttcc agaacctcag cgtgatcggc    1740
ttccggatcc tgctgctgaa ggtggccggc ttcaacctgc tgatgaccct gcggctgtgg    1800
tccagctga                                                            1809

<210> 74
<211> 1797
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR2-1 (beta-P2A-alpha)

<400> 74
atgggaatta gactgctgtg cagagtggcc ttctgcttcc tggctgttgg cctggtggac      60
gtgaaagtga cccagagcag cagatacctg gtcaagagaa ccggcgagaa ggtgttcctg     120
gaatgcgtgc aggacatgga ccacgagaat atgttctggt acagacagga ccccggcctg     180
ggcctgagac tgatctactt cagctacgac gtgaagatga aggaaaaggg cgacatcccc     240
gagggctaca gcgtgtccag agagaagaaa gagcggttca gcctgatcct ggaaagcgcc     300
agcaccaacc agaccagcat gtacctgtgt gccagcggcg ccagacagat cccttacaca     360
tttggctccg gcaccagact gaccgtggtg gaagatctga acaaagtgtt ccctccagag     420
gtggccgtgt tcgagccttc tgaggccgag atcagccaca cacagaaagc cacactcgtg     480
tgcctggcca ccggcttttt tcccgatcac gtggaactgt cttggtgggt caacggcaaa     540
gaggtgcaca gcggcgtctg taccgatcct cagcctctga aagagcagcc cgctctgaac     600
gactccagat actgcctgag cagcaggctg agagtgtccg ccaccttctg gcagaacccc     660
agaaaccact tcagatgcca ggtgcagttc tacggcctga gcgagaacga tgagtggacc     720
caggatagag ccaagcctgt gacacagatc gtgtctgccg aagcctgggg cagagccgat     780
tgtggcttta cctccgtgtc ctatcagcag ggcgtgctgt ctgccaccat cctgtatgag     840
atcctgctgg gcaaagccac tctgtacgcc gtgctggtgt ctgccctggt gctgatggcc     900
atggtcaagc ggaaggattt tggctctggc gccaccaact ttagcctgct gaaacaggct     960
ggcgacgtgg aagagaaccc cggacctatg agactggtgg ccagagtgac agtgttcctg    1020
accttcggca ccatcatcga cgccaagacc acacagccca ccagcatgga ttgtgccgag    1080
ggcagagctg ccaacctgcc ttgtaatcac agcaccatca gcggcaacga gtacgtgtac    1140
tggtacaggc agatccactc tcagggccct cagtacatca tccacggcct gaagaacaac    1200
gagacaaacg agatggcctc tctgatcatc accgaggacc gcaagagcag caccctgatt    1260
ctgcctcacg ccacactgag agacaccgcc gtgtactact gtatcgtgcg ggcctacagc    1320
ggctacagca cactgacatt tggcaagggc accatgctgc tcgtgtcccc agacattcag    1380
aaccccgatc ctgcagtgta ccagctgcgg gacagcaaga gcagcgacaa gagcgtgtgc    1440
ctgttcaccg acttcgacag ccagaccaac gtgtcccaga gcaaggacag cgacgtgtac    1500
atcaccgata agtgcgtgct ggacatgcgg agcatggact tcaagagcaa cagcgccgtg    1560
gcctggtcca acaagagcga cttcgcctgc gccaacgcct tcaacaacag cattatcccc    1620
gaggacacat tcttcccaag ccccgagagc agctgcgacg tgaagctggt ggaaaagagc    1680
ttcgagacag acaccaacct gaacttccag aacctcagcg tgatcggctt ccggatcctg    1740
ctgctgaagg tggccggctt caacctgctg atgaccctgc ggctgtggtc cagctga       1797

<210> 75
<211> 1818
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR2-2 amino acid
      (beta-P2A-alpha)

<400> 75
atgggaatta gactgctgtg cagagtggcc ttctgcttcc tggctgttgg cctggtggac      60
gtgaaagtga cccagagcag cagatacctg gtcaagagaa ccggcgagaa ggtgttcctg     120
gaatgcgtgc aggacatgga ccacgagaat atgttctggt acagacagga ccccggcctg     180
ggcctgagac tgatctactt cagctacgac gtgaagatga aggaaaaggg cgacatcccc     240
gagggctaca gcgtgtccag agagaagaaa gagcggttca gcctgatcct ggaaagcgcc     300
agcaccaacc agaccagcat gtacctgtgt gccagcggcg ccagacagat cccttacaca     360
tttggctccg gcaccagact gaccgtggtg gaagatctga acaaagtgtt ccctccagag     420
gtggccgtgt tcgagccttc tgaggccgag atcagccaca cacagaaagc cacactcgtg     480
tgcctggcca ccggcttttt tcccgatcac gtggaactgt cttggtgggt caacggcaaa     540
gaggtgcaca gcggcgtctg taccgatcct cagcctctga aagagcagcc cgctctgaac     600
gactccagat actgcctgag cagcaggctg agagtgtccg ccaccttctg gcagaacccc     660
agaaaccact tcagatgcca ggtgcagttc tacggcctga gcgagaacga tgagtggacc     720
caggatagag ccaagcctgt gacacagatc gtgtctgccg aagcctgggg cagagccgat     780
tgtggcttta cctccgtgtc ctatcagcag ggcgtgctgt ctgccaccat cctgtatgag     840
atcctgctgg gcaaagccac tctgtacgcc gtgctggtgt ctgccctggt gctgatggcc     900
atggtcaagc ggaaggattt tggctctggc gccaccaact ttagcctgct gaaacaggct     960
ggcgacgtgg aagagaaccc cggacctatg aagtccctga gagtgctgct ggtcatcctg    1020
tggctgcagc tgtcttgggt ctggtcccag cagaaagagg tggaacagaa cagcggccct    1080
ctgtctgttc ctgaaggcgc tatcgcctct ctgaattgca cctacagcga cagaggcagc    1140
cagagcttct tctggtatcg gcagtacagc ggcaagagcc ccgagctgat catgttcatc    1200
tacagcaacg gcgacaaaga ggacggccgg tttacagccc agctgaacaa ggccagccag    1260
tacgtgtcac tgctgatcag agacagccag cctagcgaca gcgccaccta tctgtgtgcc    1320
gtgatcaccc tgaacaacaa cgccggcaac atgctgacct ttggcggcgg aacacggctg    1380
atggttaagc cccacattca gaaccccgat cctgcagtgt accagctgcg ggacagcaag    1440
agcagcgaca agagcgtgtg cctgttcacc gacttcgaca gccagaccaa cgtgtcccag    1500
agcaaggaca gcgacgtgta catcaccgat aagtgcgtgc tggacatgcg gagcatggac    1560
ttcaagagca acagcgccgt ggcctggtcc aacaagagcg acttcgcctg cgccaacgcc    1620
ttcaacaaca gcattatccc cgaggacaca ttcttcccaa gccccgagag cagctgcgac    1680
gtgaagctgg tggaaaagag cttcgagaca gacaccaacc tgaacttcca gaacctcagc    1740
gtgatcggct tccggatcct gctgctgaag gtggccggct tcaacctgct gatgaccctg    1800
cggctgtggt ccagctga                                                  1818

<210> 76
<211> 1429
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR3 amino acid
      (beta-P2A-alpha)

<400> 76
atgggaatta gactgctgtg cagagtggcc ttctgcttcc tggctgttgg cctggtggac      60
gtgaaagtga cccagagcag cagatacctg gtcaagagaa ccggcgagaa ggtgttcctg     120
gaatgcgtgc aggacatgga ccacgagaat atgttctggt acagacagga ccccggcctg     180
ggcctgagac tgatctactt cagctacgac gtgaagatga aggaaaaggg cgacatcccc     240
gagggctaca gcgtgtccag agagaagaaa gagcggttca gcctgatcct ggaaagcgcc     300
agcaccaacc agaccagcat gtacctgtgt gccagctctc tgtctgctgc cggcggaggc     360
tatggctaca ccttcaatta cggctacaca ttcggcagcg gcaccagact gaccgtggtg     420
gaagatctga acaaagtgtt ccctccagag gtggccgtgt tcgagccttc tgaggccgag     480
atcagccaca cacagaaagc cacactcgtg tgcctggcca ccggcttttt tcccgatcac     540
gtggaactgt cttggtgggt caacggcaaa gaggtgcaca gcggcgtctg taccgatcct     600
cagcctctga aagagcagcc cgctctgaac gactccagat actgcctgag cagcaggctg     660
agagtgtccg ccaccttctg gcagaacccc agaaaccact tcagatgcca ggtgcagttc     720
tacggcctga gcgagaacga tgagtggacc caggatagag ccaagcctgt gacacagatc     780
gtgtctgccg aagcctgggg cagagccgat tgtggcttta cctccgtgtc ctatcagcag     840
ggcgtgctgt ctgccaccat cctgtatgag atcctgctgg gcaaagccac tctgtacgcc     900
gtgctggtgt ctgccctggt gctgatggcc atggtcaagc ggaaggattt tggcagcggc     960
gccaccaact ttagcctgct gaaacaggct ggcgacgtgg aagagaaccc cggacctatg    1020
aagtccctga gagtgctgct ggtcatcctg tggctgcagc tgtcttgggt ctggtcccag    1080
cagaaagagg tggaacagaa cagcggccct ctgtccgttc ctgaaggcgc cattgctagc    1140
ctgaattgca cctacagcga ccggggcagc cagagcttct tctggtatag gcagtacagc    1200
ggcaagagcc ccgagctgat catgttcatc tacagcaacg gcgacaaaga ggacggccgg    1260
tttacagccc agctgaacaa ggccagccag tacgtgtcac tgctgatcag agacagccag    1320
cctagcgaca gcgccaccta tctgtgtgcc gtgacaagca atgccggcaa gtccacattt    1380
ggcgacggca caaccctgac cgtgaagccc aacattcaga accccgatc                1429

<210> 77
<211> 8298
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence pRRLSIN-P2A-aWPRE-PST1

<400> 77
tcgagggaat gaaagacccc acctgtaggt ttggcaagct agcttaagta acgccatttt      60
gcaaggcatg gaaaatacat aactgagaat agagaagttc agatcaaggt taggaacaga     120
gagacagcag aatatgggcc aaacaggata tctgtggtaa gcagttcctg ccccggctca     180
gggccaagaa cagatggtcc ccagatgcgg tcccgccctc agcagtttct agagaaccat     240
cagatgtttc cagggtgccc caaggacctg aaaatgaccc tgtgccttat ttgaactaac     300
caatcagttc gcttctcgct tctgttcgcg cgcttctgct ccccgagctc aataaaagag     360
cccacaaccc ctcactcggc gcgccggcca ccatgagcaa ccaggtgctg tgctgcgtgg     420
tgctgtgttt cctgggcgcc aacaccgtgg acggcggcat cacccagagc cccaagtacc     480
tgttccggaa agagggccag aacgtcaccc tgagctgcga gcagaacctg aaccacgacg     540
ccatgtactg gtacagacag gaccccggac agggcctgcg gctgatctac tacagccaga     600
tcgtgaacga cttccagaag ggagatatcg ccgagggcta cagcgtgtcc agagagaaga     660
aagagtcctt cccactgacc gtgaccagcg cccagaagaa ccccaccgcc ttctacctgt     720
gcgccagctc tcctggcgcc ctgtacgagc agtacttcgg ccctggcacc cggctgacag     780
tgaccgagga cctgaagaac gtgttccccc cagaggtggc cgtgttcgag cctagcgagg     840
ccgagatcag ccacacccag aaagccaccc tcgtgtgcct ggccaccggc ttttaccccg     900
accacgtgga actgtcttgg tgggtcaacg gcaaagaggt gcacagcggc gtctgcaccg     960
acccccagcc cctgaaagag cagcccgccc tgaacgacag ccggtactgt ctgagcagca    1020
gactgagagt gtccgccacc ttctggcaga acccccggaa ccacttcaga tgccaggtgc    1080
agttctacgg cctgagcgag aacgacgagt ggacccagga ccgggccaag cccgtgaccc    1140
agatcgtgtc tgctgaggcc tggggcagag ccgattgcgg cttcaccagc gagagctacc    1200
agcagggcgt gctgagcgcc accatcctgt acgagatcct gctgggcaag gccaccctgt    1260
acgccgtgct ggtgtccgcc ctggtgctga tggccatggt caagcggaag gacagccggg    1320
gcggttccgg agccacgaac ttctctctgt taaagcaagc aggagacgtg gaagaaaacc    1380
ccggtcccat gaccagcatc cgggccgtgt tcatcttcct gtggctgcag ctggacctcg    1440
tcaacggcga gaacgtggaa cagcacccca gcaccctgag cgtgcaggaa ggcgacagcg    1500
ccgtcatcaa gtgcacctac agcgactccg ccagcaacta cttcccctgg tacaagcagg    1560
aactgggcaa gcggccccag ctgatcatcg acatccggtc caacgtgggc gagaagaagg    1620
accagcggat cgccgtgacc ctgaacaaga ccgccaagca cttcagcctg cacatcaccg    1680
agacacagcc cgaggactcc gccgtgtact tctgtgccgc caccgaggac taccagctga    1740
tctggggagc cggcaccaag ctgatcatta agcccgacat ccagaacccc gaccctgcag    1800
tgtaccagct gcgggacagc aagagcagcg acaagagcgt gtgcctgttc accgacttcg    1860
acagccagac caacgtgtcc cagagcaagg acagcgacgt gtacatcacc gataagtgcg    1920
tgctggacat gcggagcatg gacttcaaga gcaacagcgc cgtggcctgg tccaacaaga    1980
gcgacttcgc ctgcgccaac gccttcaaca acagcattat ccccgaggac acattcttcc    2040
caagccccga gagcagctgc gacgtgaagc tggtggaaaa gagcttcgag acagacacca    2100
acctgaactt ccagaacctc agcgtgatcg gcttccggat cctgctgctg aaggtggccg    2160
gcttcaacct gctgatgacc ctgcggctgt ggtccagctg agtcgacaat caacctctgg    2220
attacaaaat ttgtgaaaga ttgactggta ttcttaacta tgttgctcct tttacgctat    2280
gtggatacgc tgctttaatg cctttgtatc atgctattgc ttcccgtatg gctttcattt    2340
tctcctcctt gtataaatcc tggttgctgt ctctttatga ggagttgtgg cccgttgtca    2400
ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac ccccactggt tggggcattg    2460
ccaccacctg tcagctcctt tccgggactt tcgctttccc cctccctatt gccacggcgg    2520
aactcatcgc cgcctgcctt gcccgctgct ggacaggggc tcggctgttg ggcactgaca    2580
attccgtggt gttgtcgggg aaatcatcgt cctttccttg gctgctcgcc tgtgttgcca    2640
cctggattct gcgcgggacg tccttctgct acgtcccttc ggccctcaat ccagcggacc    2700
ttccttcccg cggcctgctg ccggctctgc ggcctcttcc gcgtcttcgc cttcgccctc    2760
agacgagtcg gatctccctt tgggccgcct ccccgcctgg aattcgagct cggtaccttt    2820
aagaccaatg acttacaagg cagctgtaga tcttagccac tttttaaaag aaaagggggg    2880
actggaaggg ctaattcact cccaacgaag acaagatctg ctttttgctt gtactgggtc    2940
tctctggtta gaccagatct gagcctggga gctctctggc taactaggga acccactgct    3000
taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga    3060
ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtag    3120
tagttcatgt catcttatta ttcagtattt ataacttgca aagaaatgaa tatcagagag    3180
tgagaggaac ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa    3240
tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa    3300
tgtatcttat catgtctggc tctagctatc ccgcccctaa ctccgcccag ttccgcccat    3360
tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc cgcctcggcc    3420
tctgagctat tccagaagta gtgaggaggc ttttttggag gcctaggctt ttgcgtcgag    3480
acgtacccaa ttcgccctat agtgagtcgt attacgcgcg ctcactggcc gtcgttttac    3540
aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa tcgccttgca gcacatcccc    3600
ctttcgccag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc caacagttgc    3660
gcagcctgaa tggcgaatgg cgcgacgcgc cctgtagcgg cgcattaagc gcggcgggtg    3720
tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg    3780
ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg    3840
ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt    3900
agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt    3960
tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta    4020
tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa    4080
atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg tttacaattt    4140
cccaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat    4200
acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg    4260
aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc    4320
attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga    4380
tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga    4440
gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg    4500
cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc    4560
tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac    4620
agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact    4680
tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca    4740
tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg    4800
tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact    4860
acttactcta gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg    4920
accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg    4980
tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat    5040
cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc    5100
tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat    5160
actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt    5220
tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc    5280
cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt    5340
gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac    5400
tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt    5460
gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct    5520
gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga    5580
ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac    5640
acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg    5700
agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt    5760
cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc    5820
tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg    5880
gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc    5940
ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc    6000
ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag    6060
cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca    6120
ttaatgcagc tggcacgaca ggtttcccga ctggaaagcg ggcagtgagc gcaacgcaat    6180
taatgtgagt tagctcactc attaggcacc ccaggcttta cactttatgc ttccggctcg    6240
tatgttgtgt ggaattgtga gcggataaca atttcacaca ggaaacagct atgaccatga    6300
ttacgccaag cgcgcaatta accctcacta aagggaacaa aagctggagc tgcaagctta    6360
atgtagtctt atgcaatact cttgtagtct tgcaacatgg taacgatgag ttagcaacat    6420
gccttacaag gagagaaaaa gcaccgtgca tgccgattgg tggaagtaag gtggtacgat    6480
cgtgccttat taggaaggca acagacgggt ctgacatgga ttggacgaac cactgaattg    6540
ccgcattgca gagatattgt atttaagtgc ctagctcgat acaataaacg ggtctctctg    6600
gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc    6660
tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg    6720
taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg    6780
aacagggacc tgaaagcgaa agggaaacca gagctctctc gacgcaggac tcggcttgct    6840
gaagcgcgca cggcaagagg cgaggggcgg cgactggtga gtacgccaaa aattttgact    6900
agcggaggct agaaggagag agatgggtgc gagagcgtca gtattaagcg ggggagaatt    6960
agatcgcgat gggaaaaaat tcggttaagg ccagggggaa agaaaaaata taaattaaaa    7020
catatagtat gggcaagcag ggagctagaa cgattcgcag ttaatcctgg cctgttagaa    7080
acatcagaag gctgtagaca aatactggga cagctacaac catcccttca gacaggatca    7140
gaagaactta gatcattata taatacagta gcaaccctct attgtgtgca tcaaaggata    7200
gagataaaag acaccaagga agctttagac aagatagagg aagagcaaaa caaaagtaag    7260
accaccgcac agcaagcggc cgctgatctt cagacctgga ggaggagata tgagggacaa    7320
ttggagaagt gaattatata aatataaagt agtaaaaatt gaaccattag gagtagcacc    7380
caccaaggca aagagaagag tggtgcagag agaaaaaaga gcagtgggaa taggagcttt    7440
gttccttggg ttcttgggag cagcaggaag cactatgggc gcagcctcaa tgacgctgac    7500
ggtacaggcc agacaattat tgtctggtat agtgcagcag cagaacaatt tgctgagggc    7560
tattgaggcg caacagcatc tgttgcaact cacagtctgg ggcatcaagc agctccaggc    7620
aagaatcctg gctgtggaaa gatacctaaa ggatcaacag ctcctgggga tttggggttg    7680
ctctggaaaa ctcatttgca ccactgctgt gccttggaat gctagttgga gtaataaatc    7740
tctggaacag atttggaatc acacgacctg gatggagtgg gacagagaaa ttaacaatta    7800
cacaagctta atacactcct taattgaaga atcgcaaaac cagcaagaaa agaatgaaca    7860
agaattattg gaattagata aatgggcaag tttgtggaat tggtttaaca taacaaattg    7920
gctgtggtat ataaaattat tcataatgat agtaggaggc ttggtaggtt taagaatagt    7980
ttttgctgta ctttctatag tgaatagagt taggcaggga tattcaccat tatcgtttca    8040
gacccacctc ccaaccccga ggggacccga caggcccgaa ggaatagaag aagaaggtgg    8100
agagagagac agagacagat ccattcgatt agtgaacgga tctcgacggt atcggttaac    8160
ttttaaaaga aaagggggga ttggggggta cagtgcaggg gaaagaatag tagacataat    8220
agcaacagac atacaaacta aagaattaca aaaacaaatt acaaaaattc aaaattttat    8280
cgatcacgag actagccg                                                  8298



<210> 78
<211> 2949
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Human BRAF

<400> 78
cgcctccctt ccccctcccc gcccgacagc ggccgctcgg gccccggctc tcggttataa      60
gatggcggcg ctgagcggtg gcggtggtgg cggcgcggag ccgggccagg ctctgttcaa     120
cggggacatg gagcccgagg ccggcgccgg cgccggcgcc gcggcctctt cggctgcgga     180
ccctgccatt ccggaggagg tgtggaatat caaacaaatg attaagttga cacaggaaca     240
tatagaggcc ctattggaca aatttggtgg ggagcataat ccaccatcaa tatatctgga     300
ggcctatgaa gaatacacca gcaagctaga tgcactccaa caaagagaac aacagttatt     360
ggaatctctg gggaacggaa ctgatttttc tgtttctagc tctgcatcaa tggataccgt     420
tacatcttct tcctcttcta gcctttcagt gctaccttca tctctttcag tttttcaaaa     480
tcccacagat gtggcacgga gcaaccccaa gtcaccacaa aaacctatcg ttagagtctt     540
cctgcccaac aaacagagga cagtggtacc tgcaaggtgt ggagttacag tccgagacag     600
tctaaagaaa gcactgatga tgagaggtct aatcccagag tgctgtgctg tttacagaat     660
tcaggatgga gagaagaaac caattggttg ggacactgat atttcctggc ttactggaga     720
agaattgcat gtggaagtgt tggagaatgt tccacttaca acacacaact ttgtacgaaa     780
aacgtttttc accttagcat tttgtgactt ttgtcgaaag ctgcttttcc agggtttccg     840
ctgtcaaaca tgtggttata aatttcacca gcgttgtagt acagaagttc cactgatgtg     900
tgttaattat gaccaacttg atttgctgtt tgtctccaag ttctttgaac accacccaat     960
accacaggaa gaggcgtcct tagcagagac tgccctaaca tctggatcat ccccttccgc    1020
acccgcctcg gactctattg ggccccaaat tctcaccagt ccgtctcctt caaaatccat    1080
tccaattcca cagcccttcc gaccagcaga tgaagatcat cgaaatcaat ttgggcaacg    1140
agaccgatcc tcatcagctc ccaatgtgca tataaacaca atagaacctg tcaatattga    1200
tgacttgatt agagaccaag gatttcgtgg tgatggagga tcaaccacag gtttgtctgc    1260
taccccccct gcctcattac ctggctcact aactaacgtg aaagccttac agaaatctcc    1320
aggacctcag cgagaaagga agtcatcttc atcctcagaa gacaggaatc gaatgaaaac    1380
acttggtaga cgggactcga gtgatgattg ggagattcct gatgggcaga ttacagtggg    1440
acaaagaatt ggatctggat catttggaac agtctacaag ggaaagtggc atggtgatgt    1500
ggcagtgaaa atgttgaatg tgacagcacc tacacctcag cagttacaag ccttcaaaaa    1560
tgaagtagga gtactcagga aaacacgaca tgtgaatatc ctactcttca tgggctattc    1620
cacaaagcca caactggcta ttgttaccca gtggtgtgag ggctccagct tgtatcacca    1680
tctccatatc attgagacca aatttgagat gatcaaactt atagatattg cacgacagac    1740
tgcacagggc atggattact tacacgccaa gtcaatcatc cacagagacc tcaagagtaa    1800
taatatattt cttcatgaag acctcacagt aaaaataggt gattttggtc tagctacagt    1860
gaaatctcga tggagtgggt cccatcagtt tgaacagttg tctggatcca ttttgtggat    1920
ggcaccagaa gtcatcagaa tgcaagataa aaatccatac agctttcagt cagatgtata    1980
tgcatttgga attgttctgt atgaattgat gactggacag ttaccttatt caaacatcaa    2040
caacagggac cagataattt ttatggtggg acgaggatac ctgtctccag atctcagtaa    2100
ggtacggagt aactgtccaa aagccatgaa gagattaatg gcagagtgcc tcaaaaagaa    2160
aagagatgag agaccactct ttccccaaat tctcgcctct attgagctgc tggcccgctc    2220
attgccaaaa attcaccgca gtgcatcaga accctccttg aatcgggctg gtttccaaac    2280
agaggatttt agtctatatg cttgtgcttc tccaaaaaca cccatccagg cagggggata    2340
tggtgcgttt cctgtccact gaaacaaatg agtgagagag ttcaggagag tagcaacaaa    2400
aggaaaataa atgaacatat gtttgcttat atgttaaatt gaataaaata ctctcttttt    2460
ttttaaggtg aaccaaagaa cacttgtgtg gttaaagact agatataatt tttccccaaa    2520
ctaaaattta tacttaacat tggattttta acatccaagg gttaaaatac atagacattg    2580
ctaaaaattg gcagagcctc ttctagaggc tttactttct gttccgggtt tgtatcattc    2640
acttggttat tttaagtagt aaacttcagt ttctcatgca acttttgttg ccagctatca    2700
catgtccact agggactcca gaagaagacc ctacctatgc ctgtgtttgc aggtgagaag    2760
ttggcagtcg gttagcctgg gttagataag gcaaactgaa cagatctaat ttaggaagtc    2820
agtagaattt aataattcta ttattattct taataatttt tctataacta tttcttttta    2880
taacaatttg gaaaatgtgg atgtctttta tttccttgaa gcaataaact aagtttcttt    2940
ttataaaaa                                                            2949

<210> 79
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence AP1M1

<400> 79
Val Ile Glu Lys His Ser His Ser Arg Ile Glu Tyr Met Leu Lys Ala
 1               5                  10                  15
Lys Ser Gln Phe Lys Arg Arg Ser Thr Ala Asn
            20                  25

<210> 80
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence AP1M1

<400> 80
Val Ile Glu Lys His Ser His Ser Arg Ile Glu Tyr Met Leu Lys Ala
 1               5                  10                  15
Lys Ser Gln Phe
            20

<210> 81
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence AP1M1

<400> 81
Ser Arg Ile Glu Tyr Met Leu Lys Ala Lys Ser Gln Phe Lys Arg Arg
 1               5                  10                  15
Ser Thr Ala Asn
            20

<210> 82
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence DCAF6

<400> 82
Glu Gln Phe Leu Gln Pro Ser Thr Ser Ser Thr Met Ser Thr Gln Ala
 1               5                  10                  15
His Ser Thr Ser Ser Pro Thr Glu Ser Pro His
            20                  25

<210> 83
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence DCAF6

<400> 83
Glu Gln Phe Leu Gln Pro Ser Thr Ser Ser Thr Met Ser Thr Gln Ala
 1               5                  10                  15
His Ser Thr Ser
            20

<210> 84
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence DCAF6

<400> 84
Thr Ser Ser Thr Met Ser Thr Gln Ala His Ser Thr Ser Ser Pro Thr
 1               5                  10                  15
Glu Ser Pro His
            20

<210> 85
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence GTF2H4

<400> 85
Phe Ile Val Val Glu Thr Asn Tyr Arg Leu Tyr Ala Tyr Met Glu Ser
 1               5                  10                  15
Glu Leu Gln Ile Ala Leu Ile Ala Leu Phe Ser
            20                  25

<210> 86
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence GTF2H4

<400> 86
Phe Ile Val Val Glu Thr Asn Tyr Arg Leu Tyr Ala Tyr Met Glu Ser
 1               5                  10                  15
Glu Leu Gln Ile
            20

<210> 87
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence GTF2H4

<400> 87
Tyr Arg Leu Tyr Ala Tyr Met Glu Ser Glu Leu Gln Ile Ala Leu Ile
 1               5                  10                  15
Ala Leu Phe Ser
            20

<210> 88
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence NBPF12

<400> 88
Asp Ser Cys Gln Pro Tyr Arg Ser Ser Phe Tyr Ala Leu Gly Glu Lys
 1               5                  10                  15
His Val Gly Phe Ser Leu Asp Val Gly Glu Ile
            20                  25

<210> 89
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence NBPF12

<400> 89
Asp Ser Cys Gln Pro Tyr Arg Ser Ser Phe Tyr Ala Leu Gly Glu Lys
 1               5                  10                  15
His Val Gly Phe
            20

<210> 90
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence NBPF12

<400> 90
Ser Ser Phe Tyr Ala Leu Gly Glu Lys His Val Gly Phe Ser Leu Asp
 1               5                  10                  15
Val Gly Glu Ile
            20

<210> 91
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence ORC3

<400> 91
Glu Ser Phe Ala Thr Lys Val Leu Gln Asp Phe Ile Ile Leu Ser Ser
 1               5                  10                  15
Gln His Leu His Glu Phe Pro Leu Ile Leu Ile
            20                  25

<210> 92
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence ORC3

<400> 92
Glu Ser Phe Ala Thr Lys Val Leu Gln Asp Phe Ile Ile Leu Ser Ser
 1               5                  10                  15
Gln His Leu His
            20

<210> 93
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence ORC3

<400> 93
Leu Gln Asp Phe Ile Ile Leu Ser Ser Gln His Leu His Glu Phe Pro
 1               5                  10                  15
Leu Ile Leu Ile
            20

<210> 94
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence ROR1

<400> 94
Leu Val Pro Thr Ser Ser Trp Asn Ile Ser Ser Glu Leu Ser Lys Asp
 1               5                  10                  15
Ser Tyr Leu Thr Leu Asp Glu Pro Met Asn Asn
            20                  25

<210> 95
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence ROR1

<400> 95
Leu Val Pro Thr Ser Ser Trp Asn Ile Ser Ser Glu Leu Ser Lys Asp
 1               5                  10                  15
Ser Tyr Leu Thr
            20

<210> 96
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence ROR1

<400> 96
Asn Ile Ser Ser Glu Leu Ser Lys Asp Ser Tyr Leu Thr Leu Asp Glu
 1               5                  10                  15
Pro Met Asn Asn
            20

<210> 97
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence SF3B1

<400> 97
Gln Met Gly Gly Ser Thr Pro Val Leu Thr Pro Gly Lys Ala Pro Ile
 1               5                  10                  15
Gly Thr Pro Ala Met Asn Met Ala Thr Pro Thr
            20                  25

<210> 98
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence SF3B1

<400> 98
Gln Met Gly Gly Ser Thr Pro Val Leu Thr Pro Gly Lys Ala Pro Ile
 1               5                  10                  15
Gly Thr Pro Ala
            20

<210> 99
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence SF3B1

<400> 99
Val Leu Thr Pro Gly Lys Ala Pro Ile Gly Thr Pro Ala Met Asn Met
 1               5                  10                  15
Ala Thr Pro Thr
            20

<210> 100
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence UNKL

<400> 100
Ala His Gly Pro Leu Asp Leu Arg Pro Pro Val Cys Asp Ile Arg Glu
 1               5                  10                  15
Leu Gln Ala Gln Glu Ala Leu Gln Asn Gly Gln
            20                  25

<210> 101
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence UNKL

<400> 101
Ala His Gly Pro Leu Asp Leu Arg Pro Pro Val Cys Asp Ile Arg Glu
 1               5                  10                  15
Leu Gln Ala Gln
            20

<210> 102
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence UNKL

<400> 102
Arg Pro Pro Val Cys Asp Ile Arg Glu Leu Gln Ala Gln Glu Ala Leu
 1               5                  10                  15
Gln Asn Gly Gln
            20

<210> 103
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence ZNF700

<400> 103
Gly Glu Lys Pro Tyr Glu Cys Ser Lys Cys Asp Lys Ala Leu His Ser
 1               5                  10                  15
Ser Ser Ser Tyr His Arg His Glu Arg Ser His
            20                  25

<210> 104
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence ZNF700

<400> 104
Gly Glu Lys Pro Tyr Glu Cys Ser Lys Cys Asp Lys Ala Leu His Ser
 1               5                  10                  15
Ser Ser Ser Tyr
            20

<210> 105
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence ZNF700

<400> 105
Ser Lys Cys Asp Lys Ala Leu His Ser Ser Ser Ser Tyr His Arg His
 1               5                  10                  15
Glu Arg Ser His
            20

<210> 106
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence NVL

<400> 106
Ala Pro Cys Ile Ile Phe Ile Asp Glu Ile Asp Ala Ile Pro Pro Lys
 1               5                  10                  15
Arg Glu Val Ala Ser Lys Asp Met Glu Arg Arg
            20                  25

<210> 107
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence NVL

<400> 107
Ala Pro Cys Ile Ile Phe Ile Asp Glu Ile Asp Ala Ile Pro Pro Lys
 1               5                  10                  15
Arg Glu Val Ala
            20

<210> 108
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence NVL

<400> 108
Asp Glu Ile Asp Ala Ile Pro Pro Lys Arg Glu Val Ala Ser Lys Asp
 1               5                  10                  15
Met Glu Arg Arg
            20

<210> 109
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence MATN1

<400> 109
Ser Arg Ser Pro Asp Ile Ser Lys Val Val Ile Val Val Pro Asp Gly
 1               5                  10                  15
Arg Pro Gln Asp Ser Val Gln Asp Val Ser Ala
            20                  25

<210> 110
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence MATN1

<400> 110
Ser Arg Ser Pro Asp Ile Ser Lys Val Val Ile Val Val Pro Asp Gly
 1               5                  10                  15
Arg Pro Gln Asp
            20

<210> 111
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence MATN1

<400> 111
Lys Val Val Ile Val Val Pro Asp Gly Arg Pro Gln Asp Ser Val Gln
 1               5                  10                  15
Asp Val Ser Ala
            20

<210> 112
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CTNNA2

<400> 112
Val Arg Gln Ala Leu Gln Asp Leu Leu Ser Glu Tyr Met His Asn Thr
 1               5                  10                  15
Gly Arg Lys Glu Lys Gly Asp Pro Leu Asn Ile
            20                  25

<210> 113
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CTNNA2

<400> 113
Val Arg Gln Ala Leu Gln Asp Leu Leu Ser Glu Tyr Met His Asn Thr
 1               5                  10                  15
Gly Arg Lys Glu
            20

<210> 114
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CTNNA2

<400> 114
Leu Leu Ser Glu Tyr Met His Asn Thr Gly Arg Lys Glu Lys Gly Asp
 1               5                  10                  15
Pro Leu Asn Ile
            20

<210> 115
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence GET4

<400> 115
Arg Tyr Met Ser Gln Ser Lys His Thr Glu Ala Arg Glu Arg Met Tyr
 1               5                  10                  15
Ser Gly Ala Leu Leu Phe Phe Ser His Gly Gln
            20                  25

<210> 116
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence GET4

<400> 116
Arg Tyr Met Ser Gln Ser Lys His Thr Glu Ala Arg Glu Arg Met Tyr
 1               5                  10                  15
Ser Gly Ala Leu
            20

<210> 117
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence GET4

<400> 117
His Thr Glu Ala Arg Glu Arg Met Tyr Ser Gly Ala Leu Leu Phe Phe
 1               5                  10                  15
Ser His Gly Gln
            20

<210> 118
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence NTNG1

<400> 118
Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg Pro Ala Ile Gly Glu
 1               5                  10                  15
Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr
            20                  25

<210> 119
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence NTNG1

<400> 119
Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg Pro Ala Ile Gly Glu
 1               5                  10                  15
Ile Phe Val Asp
            20

<210> 120
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence NTNG1

<400> 120
Arg Leu Leu Arg Pro Ala Ile Gly Glu Ile Phe Val Asp Glu Leu His
 1               5                  10                  15
Leu Ala Arg Tyr
            20

<210> 121
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence SPTBN5

<400> 121
Thr Leu Leu Leu Asp Ala Trp Leu Thr Thr Lys Ala Ala Ile Ala Glu
 1               5                  10                  15
Ser Gln Asp Tyr Gly Gln Asp Leu Glu Gly Val
            20                  25

<210> 122
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence SPTBN5

<400> 122
Thr Leu Leu Leu Asp Ala Trp Leu Thr Thr Lys Ala Ala Ile Ala Glu
 1               5                  10                  15
Ser Gln Asp Tyr
            20

<210> 123
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence SPTBN5

<400> 123
Leu Thr Thr Lys Ala Ala Ile Ala Glu Ser Gln Asp Tyr Gly Gln Asp
 1               5                  10                  15
Leu Glu Gly Val
            20

<210> 124
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence DPP6

<400> 124
Leu Leu Val Ile Leu Val Ile Cys Ser Leu Ile Val Thr Leu Val Ile
 1               5                  10                  15
Leu Leu Thr Pro Ala Glu Asp Asn Ser Leu Ser
            20                  25

<210> 125
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence DPP6

<400> 125
Leu Leu Val Ile Leu Val Ile Cys Ser Leu Ile Val Thr Leu Val Ile
 1               5                  10                  15
Leu Leu Thr Pro
            20

<210> 126
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence DPP6

<400> 126
Cys Ser Leu Ile Val Thr Leu Val Ile Leu Leu Thr Pro Ala Glu Asp
 1               5                  10                  15
Asn Ser Leu Ser
            20

<210> 127
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HIAT1

<400> 127
Val Lys Gly Leu Leu Ser Phe Leu Ser Ala Pro Leu Ile Cys Ala Leu
 1               5                  10                  15
Ser Asp Val Trp Gly Arg Lys Ser Phe Leu Leu
            20                  25

<210> 128
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HIAT1

<400> 128
Val Lys Gly Leu Leu Ser Phe Leu Ser Ala Pro Leu Ile Cys Ala Leu
 1               5                  10                  15
Ser Asp Val Trp
            20

<210> 129
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HIAT1

<400> 129
Leu Ser Ala Pro Leu Ile Cys Ala Leu Ser Asp Val Trp Gly Arg Lys
 1               5                  10                  15
Ser Phe Leu Leu
            20

<210> 130
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence ITGA4

<400> 130
Gly Ser Gly Ala Val Met Asn Ala Met Glu Thr Asn Leu Phe Gly Ser
 1               5                  10                  15
Asp Lys Tyr Ala Ala Arg Phe Gly Glu Ser Ile
            20                  25

<210> 131
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence ITGA4

<400> 131
Gly Ser Gly Ala Val Met Asn Ala Met Glu Thr Asn Leu Phe Gly Ser
 1               5                  10                  15
Asp Lys Tyr Ala
            20

<210> 132
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence ITGA4

<400> 132
Ala Met Glu Thr Asn Leu Phe Gly Ser Asp Lys Tyr Ala Ala Arg Phe
 1               5                  10                  15
Gly Glu Ser Ile
            20

<210> 133
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence MYO1A

<400> 133
Ser Val Arg Phe Lys Glu Asn Ser Val Ala Val Lys Val Ile Gln Gly
 1               5                  10                  15
Pro Ala Gly Gly Asp Asn Ser Lys Leu Arg Tyr
            20                  25

<210> 134
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence MYO1A

<400> 134
Ser Val Arg Phe Lys Glu Asn Ser Val Ala Val Lys Val Ile Gln Gly
 1               5                  10                  15
Pro Ala Gly Gly
            20

<210> 135
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence MYO1A

<400> 135
Ser Val Ala Val Lys Val Ile Gln Gly Pro Ala Gly Gly Asp Asn Ser
 1               5                  10                  15
Lys Leu Arg Tyr
            20

<210> 136
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TRAC-gRNA-1

<400> 136
agagtctctc agctggtaca                                                  20

<210> 137
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequenceTRAC-gRNA-2

<400> 137
tgtgctagac atgaggtcta                                                  20

<210> 138
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TRBC-gRNA-1

<400> 138
gcagtatctg gagtcattga                                                  20

<210> 139
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TRBC-gRNA-2

<400> 139
ggagaatgac gagtggaccc                                                  20

<210> 140
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence B2M-gRNA

<400> 140
cgcgagcaca gctaaggcca                                                  20

<210> 141
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence PD-1-gRNA

<400> 141
ggccaggatg gttcttaggt                                                  20

<210> 142
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence sgRNA Forward Oligo:
      TRAC_sgRNA_pLenti_F1

<400> 142
caccggagaa tcaaaatcgg tgaat                                            25

<210> 143
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence sgRNA Reverse Oligo:
      TRAC_sgRNA_pLenti_R1

<400> 143
aaacattcac cgattttgat tctcc                                            25

<210> 144
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence PD1_sgRNA_F1

<400> 144
caccgcagtt gtgtgacacg gaag                                             24

<210> 145
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence PD1_sgRNA_R1

<400> 145
aaaccttccg tgtcacacaa ctgc                                             24

<210> 146
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CTLA4_sgRNA_F1

<400> 146
caccggcaaa ggtgagtgag acttt                                            25

<210> 147
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CTLA4_sgRNA_R1

<400> 147
aaacaaagtc tcactcacct ttgcc                                            25

<210> 148
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence LAG3_sgRNA_F1

<400> 148
caccggtttc tgcagccgct ttggg                                            25

<210> 149
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence LAG3_sgRNA_R1

<400> 149
aaaccccaaa gcggctgcag aaacc                                            25
