                         SEQUENCE LISTING

<110>  Washington University in St. Louis
       Imai, Shin-ichiro
       Grozio, Alessia
 
<120>  COMPOSITIONS AND METHODS OF TREATMENT USING NICOTINAMIDE 
       MONONUCLEOTIDE

<130>  WSTL 17227.WO

<150>  62/543,856
<151>  2017-08-10

<150>  62/653,348
<151>  2018-04-05

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  3166
<212>  DNA
<213>  Mus musculus

<400>  1
atggcccaga ggtctccgca agaactcttc cacgaggcag cccagcaggg catcctggcc       60

cagccccagc cctggtggaa gatccagctg ttcatgtggg agccggtgct gtttgggacc      120

tgggatggtg tgttcacatc ctgcatgatc aacatttttg gcgttgtcct tttcttgagg      180

accggctggc tggtgggaaa cacaggtgtg ctcctgggct tgctcctggt gtccttcgtc      240

gtcctcgtgg ccctcatcac cgtgctgtcg ggcattggtg tcgcagagca tggcgggatc      300

agcagtggcg gtgtctactc catgatctcc tcggtgcttg gtgggcagat gggaggcact      360

gtggggctgc tctatgtatt tggacagtgt gttgcaggtg ctatgtacat caccggcttt      420

gcggagtcca tctcagatct gctgggactt ggggacatct gggcagtgcg tggaatttca      480

gttgctgtgc ttctggcttt gctgggcatc aacctggcag gtgtcaagtg gattatccgc      540

ctccagctgc tgctgctgct cctgctggct gtctcgaccc tggactttgt ggtgggctct      600

ttcacccacc tggacccaga acatggcttt attggctact ccccagaact gctacagagc      660

aacattctgc cagagtacag ccccggggag tcattcttca ctgtgtttgg ggtgttcttc      720

cctgcagcta caggagtcat ggctggcttc aacatgggag gagacctgag agaccctgct      780

gacagtgtcc ccttaggctc cctagcagct gttggcgtct cgtggtttct ctacatcatc      840

tttgccttcc tgcttggtgc cgtctgtacc cgagaggccc tccgctctga cttcctgata      900

gctgaaaagg tgtctctggt tggtttcctc ttcctattgg gcctgtacat ctcatccctg      960

gcttcctgta tggggggact ctatggcgca ccccggatcc tgcagtgcat cgcccaggac     1020

aaagtcatcc ctgcactcgc ctttctggcg aatgggaaag ggccaaataa aacaccggta     1080

gcagccatct gcctgaccag cttggtgacc atggcctttg tcctggtggg tcaggtgaat     1140

gttctggcgc ccgttgtcac catcaatttc atgctgacct acatcatggt ggactactct     1200

tacttcgccc tctccatggc tcactgtggc ctcgccccat ctcctgagcc cgtccccaga     1260

caaggcccag atactctgca ctgctctgag cacctgctcc aggacagggc tcccagctac     1320

ggctctgatg tccctgccag aagcctctct gagggcaccc tgctggagtt caccaaggac     1380

atggatcagt tcctccagcc aatagaggaa ctggagagtc gtcagcttgg gtcaagagaa     1440

ggaaacaacc caaagaatca gaagcgcaag ggtaagaaag gcgccaagca aaccctacaa     1500

gatagcttcc tcttggaccc tgggtctcct ttgtcctttc ctacgaggac ttctgagagg     1560

ttgtctgttg ccttctgtgg ggagcaagag tcctatcaga agcagcagac ttctaggagt     1620

gaatcacatg accatcttgt tcctgatcta cgcaaccagc ctagagtgaa cagagaagat     1680

ttctttctga aatgcagact tcaggaacaa gagatccaga gaagaccaag tgttttctat     1740

gcttgcatgt gtaacccctg ggtctccctg ttaggggctc ttgcatccct gctcatcatg     1800

tttgtgatcc agtggctcta taccctagct agtatgggtg ttgctgccct tgtgtatttc     1860

tacattggcc aggcaagtcc aggcctttac ctcggatcag catcaaactt cagctttttc     1920

caatggatga agtccttctt ggtcccctcc tgcaggagcc tgaggtccgc ccaggagcaa     1980

atcatcttgg cgccatcacc agccaaggtt gacatggcaa tgactcagct tacccaggac     2040

aatgcagact tcgccacccg agatcgttac caccactcct ccttcctgag ccgggagcag     2100

ttgatgcctc cctactagga cctcgctgga ccccaccttt ctagaagccg ctgtggagat     2160

gggggaccca agcctcagaa cctttggaag ttgcttctac caataagaaa acccaagact     2220

ggtcttccca ccacagcctt ggacgctgga aatcacattc cggtctgaaa tggcatgtct     2280

agccagatac taggtatgac tatggcttcc acgtgtgccc aacctgaaga gtccacaggc     2340

accaggatga tcaggtgaca ccaagacaac caaatgtgga gaatcaaaac gagatttctt     2400

attctaaggg gccaaaataa acacttcttt ttaattttat tgttttattt tttattattt     2460

ttaaagaatt atatatatat acatatactg tagctatttt cagacagaaa atagcatcac     2520

cagaagaggg catcggatcc cattacagat ggttgtgagc caccatgtgg ttgctgggaa     2580

ttgaactcag gatctctgga agaacagtca gtgctcctaa ctgctgagcc atctctccag     2640

caccctcccc tgttttattt attttgtaat gtatactaac tacactcaca tggttcccaa     2700

gccacagagt atagaaaccc ccttctccct gtttctcatc tgtttggtgt ccgtccccca     2760

tcacaggggc aaccacttct catgcaaaca tcagccacct ctttacagac ccctcccatc     2820

tgcaaatgca gctctgttta caatgcacta catcccgctc ttctccctta atctgccata     2880

gaagcatttc catgaagatg cttacacagt ttcctcctta tgtctctatg tctgaatgtg     2940

ccttaattta tatactcagc ctcacgagga cggcatttag cttcattctg atattttgct     3000

attacagccg cttctgcaaa gagtcactgt gtttgtgtgc acagtcgtga aggatacctg     3060

aagataaatt ctcagaagga gaattacagg gtgactgggg atgtacattt gtaagctgtt     3120

actgtttgga gaaatgcttt ttaattaaaa agtcaatcaa atacca                    3166


<210>  2
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  2
atactcgagg agaatggccc agaggtctc                                         29


<210>  3
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  3
tcaactacgg agggatgatc gagctcatt                                         29


<210>  4
<211>  10
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  4
cttcctgtca                                                              10


<210>  5
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  5
gcctagagtg aacagagaag a                                                 21


<210>  6
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  6

Ala Gln Arg Ser Pro Gln Glu Leu Phe His Glu Ala Ala Gln Gln Gly 
1               5                   10                  15      


Cys 
    


<210>  7
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  7
agtgcatgta tagacgtatg                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  8
cctcacaaat atttacaggc                                                   20


<210>  9
<211>  2004
<212>  DNA
<213>  Mus musculus

<400>  9
atggcccaga ggtctccgca agaactcttc cacgaggcag cccagcaggg catcctggcc       60

cagccccagc cctggtggaa gatccagctg ttcatgtggg agccggtgct gtttgggacc      120

tgggatggtg tgttcacatc ctgcatgatc aacatttttg gcgttgtcct tttcttgagg      180

accggctggc tggtgggaaa cacaggtgtg ctcctgggct tgctcctggt gtccttcgtc      240

gtcctcgtgg ccctcatcac cgtgctgtcg ggcattggtg tcgcagagca tggcgggatc      300

agcagtggcg gtgtctactc catgatctcc tcggtgcttg gtgggcagat gggaggcact      360

gtggggctgc tctatgtatt tggacagtgt gttgcaggtg ctatgtacat caccggcttt      420

gcggagtcca tctcagatct gctgggactt ggggacatct gggcagtgcg tggaatttca      480

gttgctgtgc ttctggcttt gctgggcatc aacctggcag gtgtcaagtg gattatccgc      540

ctccagctgc tgctgctgct cctgctggct gtctcgaccc tggactttgt ggtgggctct      600

ttcacccacc tggacccagg agtcatggct ggcttcaaca tgggaggaga cctgagagac      660

cctgctgaca gtgtcccctt aggctcccta gcagctgttg gcgtctcgtg gtttctctac      720

atcatctttg ccttcctgct tggtgccgtc tgtacccgag aggccctccg ctctgacttc      780

ctgatagctg aaaaggtgtc tctggttggt ttcctcttcc tattgggcct gtacatctca      840

tccctggctt cctgtatggg gggactctat ggcgcacccc ggatcctgca gtgcatcgcc      900

caggacaaag tcatccctgc actcgccttt ctggcgaatg ggaaagggcc aaataaaaca      960

ccggtagcag ccatctgcct gaccagcttg gtgaccatgg cctttgtcct ggtgggtcag     1020

gtgaatgttc tggcgcccgt tgtcaccatc aatttcatgc tgacctacat catggtggac     1080

tactcttact tcgccctctc catggctcac tgtggcctcg ccccatctcc tgagcccgtc     1140

cccagacaag gcccagatac tctgcactgc tctgagcacc tgctccagga cagggctccc     1200

agctacggct ctgatgtccc tgccagaagc ctctctgagg gcaccctgct ggagttcacc     1260

aaggacatgg atcagttcct ccagccaata gaggaactgg agagtcgtca gcttgggtca     1320

agagaaggaa acaacccaaa gaatcagaag cgcaagggta agaaaggcgc caagcaaacc     1380

ctacaagata gcttcctctt ggaccctggg tctcctttgt cctttcctac gaggacttct     1440

gagaggttgt ctgttgcctt ctgtggggag caagagtcct atcagaagca gcagacttct     1500

aggagtgaat cacatgacca tcttgttcct gatctacgca accagcctag agtgaacaga     1560

gaagatttct ttctgaaatg cagacttcag gaacaagaga tccagagaag accaagtgtt     1620

ttctatgctt gcatgtgtaa cccctgggtc tccctgttag gggctcttgc atccctgctc     1680

atcatgtttg tgatccagtg gctctatacc ctagctagta tgggtgttgc tgcccttgtg     1740

tatttctaca ttggccaggc aagtccaggc ctttacctcg gatcagcatc aaacttcagc     1800

tttttccaat ggatgaagtc cttcttggtc ccctcctgca ggagcctgag gtccgcccag     1860

gagcaaatca tcttggcgcc atcaccagcc aaggttgaca tggcaatgac tcagcttacc     1920

caggacaatg cagacttcgc cacccgagat cgttaccacc actcctcctt cctgagccgg     1980

gagcagttga tgcctcccta ctag                                            2004


<210>  10
<211>  1779
<212>  DNA
<213>  Mus musculus

<400>  10
atggcccaga ggtctccgca agaactcttc cacgaggcag cccagcagtg tgttgcaggt       60

gctatgtaca tcaccggctt tgcggagtcc atctcagatc tgctgggact tggggacatc      120

tgggcagtgc gtggaatttc agttgctgtg cttctggctt tgctgggcat caacctggca      180

ggtgtcaagt ggattatccg cctccagctg ctgctgctgc tcctgctggc tgtctcgacc      240

ctggactttg tggtgggctc tttcacccac ctggacccag aacatggctt tattggctac      300

tccccagaac tgctacagag caacattctg ccagagtaca gccccgggga gtcattcttc      360

actgtgtttg gggtgttctt ccctgcagct acaggagtca tggctggctt caacatggga      420

ggagacctga gagaccctgc tgacagtgtc cccttaggct ccctagcagc tgttggcgtc      480

tcgtggtttc tctacatcat ctttgccttc ctgcttggtg ccgtctgtac ccgagaggcc      540

ctccgctctg acttcctgat agctgaaaag gtgtctctgg ttggtttcct cttcctattg      600

ggcctgtaca tctcatccct ggcttcctgt atggggggac tctatggcgc accccggatc      660

ctgcagtgca tcgcccagga caaagtcatc cctgcactcg cctttctggc gaatgggaaa      720

gggccaaata aaacaccggt agcagccatc tgcctgacca gcttggtgac catggccttt      780

gtcctggtgg gtcaggtgaa tgttctggcg cccgttgtca ccatcaattt catgctgacc      840

tacatcatgg tggactactc ttacttcgcc ctctccatgg ctcactgtgg cctcgcccca      900

tctcctgagc ccgtccccag acaaggccca gatactctgc actgctctga gcacctgctc      960

caggacaggg ctcccagcta cggctctgat gtccctgcca gaagcctctc tgagggcacc     1020

ctgctggagt tcaccaagga catggatcag ttcctccagc caatagagga actggagagt     1080

cgtcagcttg ggtcaagaga aggaaacaac ccaaagaatc agaagcgcaa gggtaagaaa     1140

ggcgccaagc aaaccctaca agatagcttc ctcttggacc ctgggtctcc tttgtccttt     1200

cctacgagga cttctgagag gttgtctgtt gccttctgtg gggagcaaga gtcctatcag     1260

aagcagcaga cttctaggag tgaatcacat gaccatcttg ttcctgatct acgcaaccag     1320

cctagagtga acagagaaga tttctttctg aaatgcagac ttcaggaaca agagatccag     1380

agaagaccaa gtgttttcta tgcttgcatg tgtaacccct gggtctccct gttaggggct     1440

cttgcatccc tgctcatcat gtttgtgatc cagtggctct ataccctagc tagtatgggt     1500

gttgctgccc ttgtgtattt ctacattggc caggcaagtc caggccttta cctcggatca     1560

gcatcaaact tcagcttttt ccaatggatg aagtccttct tggtcccctc ctgcaggagc     1620

ctgaggtccg cccaggagca aatcatcttg gcgccatcac cagccaaggt tgacatggca     1680

atgactcagc ttacccagga caatgcagac ttcgccaccc gagatcgtta ccaccactcc     1740

tccttcctga gccgggagca gttgatgcct ccctactag                            1779


<210>  11
<211>  2145
<212>  DNA
<213>  Homo sapiens

<400>  11
atgacccaga tgtcccaggt gcaggagctc ttccatgagg cagcccagca ggatgccctg       60

gcccagcccc agccctggtg gaagacccag ctgttcatgt gggagcctgt gctgtttggg      120

acctgggatg gtgtgttcac atcctgcatg atcaacatct ttggggttgt gctcttcctg      180

aggactggct ggctggtggg aaacacagga gtgctcctgg gcatgttcct ggtgtccttc      240

gtcatcctgg tggccctcgt cacggtgctg tctggcattg gcgtcgggga gcgcagcagc      300

atcggcagcg gtggcgtcta ctccatgatc tcctcggtcc tgggtgggca gacgggaggc      360

accatcgggc tgctctatgt gtttggacag tgtgttgcag gtgccatgta tatcaccggc      420

tttgctgaat ccatctcgga tttgctgggc ctcgggaata tctgggctgt gcgaggaatt      480

tcagttgcgg tgcttctggc cttgctgggc attaacctcg caggtgtcaa atggataatc      540

cgcctccagc tgctgttgct gttcctgctg gccgtgtcca cactggactt tgtggtgggt      600

tctttcaccc acctggaccc agaacatggt ttcattggat attcacccga actgctacag      660

aacaacacgc tgcccgatta cagcccgggg gaatcttttt tcactgtctt tggggttttc      720

ttcccagcgg ctacaggagt catggccggc ttcaacatgg ggggcgacct cagggagcct      780

gccgccagca ttcccctggg ctccctggca gctgttggca tctcgtggtt tctgtacatc      840

atcttcgtct tcctcctggg cgccatctgc actcgagagg cccttcgcta tgacttcctg      900

atagcggaaa aggtatccct catgggcttc ctgttccttt tgggcttata catctcgtcc      960

ctggcttcct gcatgggagg actttatgga gctccccgca tcctgcagtg cattgcccag     1020

gagaaagtga tccctgcact tgcctgtctg ggacaaggga aggggccaaa caaaacaccc     1080

gtggctgcca tctgcctgac cagcttggtg accatggcct ttgtttttgt gggtcaagtg     1140

aacgttctgg cccccatcgt caccatcaac ttcatgctga catacgttgc agtggactac     1200

tcttacttct ccctgtccat gtgttcctgc agcctgaccc cggtgcctga gccggtgctc     1260

agggagggcg cagaaggcct ccactgctct gagcacctgc tcttagagaa agctcccagt     1320

tacggctctg agggacctgc ccaaagagtc ttggagggca cgctactgga attcaccaag     1380

gacatggatc agctcctcca gctaaccagg aagcttgaga gtagccagcc caggcaagga     1440

gagggtaaca ggaccccaga aagtcagaag aggaaaagca agaaggccac caagcagacc     1500

ctacaagata gcttcctctt ggacctcaaa tcccctcctt ctttccctgt cgagatctct     1560

gacaggttgc ccgctgcctc ctgggagggg caggagtcct gctggaacaa gcagacttcc     1620

aagagcgaag ggactcagcc tgagggaaca tatggagagc aacttgttcc tgagctgtgc     1680

aaccaatcag agtccagtgg agaagatttc ttcctgaagt ccaggctcca agaacaagat     1740

gtctggagaa gatccacttc tttctatacc cacatgtgca acccctgggt ctccctgttg     1800

ggggctgttg ggtcccttct catcatgttt gtgatacagt gggtgtatac cctggttaac     1860

atgggtgttg ctgccatcgt gtatttctac attggccggg ccagtccagg gcttcacctt     1920

ggatcagcct ccaacttcag ctttttccgg tggatgaggt ctctcttgct cccctcctgc     1980

aggagcttgc ggtcccctca ggagcagatc atcttggcgc cgtccctggc taaggttgac     2040

atggagatga ctcagctcac ccaggagaat gcagacttcg ccactcggga tcgctaccac     2100

cactcctccc tcgtgaaccg ggagcagctg atgcctcact actag                     2145


<210>  12
<211>  705
<212>  PRT
<213>  Mus musculus

<400>  12

Met Ala Gln Arg Ser Pro Gln Glu Leu Phe His Glu Ala Ala Gln Gln 
1               5                   10                  15      


Gly Ile Leu Ala Gln Pro Gln Pro Trp Trp Lys Ile Gln Leu Phe Met 
            20                  25                  30          


Trp Glu Pro Val Leu Phe Gly Thr Trp Asp Gly Val Phe Thr Ser Cys 
        35                  40                  45              


Met Ile Asn Ile Phe Gly Val Val Leu Phe Leu Arg Thr Gly Trp Leu 
    50                  55                  60                  


Val Gly Asn Thr Gly Val Leu Leu Gly Leu Leu Leu Val Ser Phe Val 
65                  70                  75                  80  


Val Leu Val Ala Leu Ile Thr Val Leu Ser Gly Ile Gly Val Ala Glu 
                85                  90                  95      


His Gly Gly Ile Ser Ser Gly Gly Val Tyr Ser Met Ile Ser Ser Val 
            100                 105                 110         


Leu Gly Gly Gln Met Gly Gly Thr Val Gly Leu Leu Tyr Val Phe Gly 
        115                 120                 125             


Gln Cys Val Ala Gly Ala Met Tyr Ile Thr Gly Phe Ala Glu Ser Ile 
    130                 135                 140                 


Ser Asp Leu Leu Gly Leu Gly Asp Ile Trp Ala Val Arg Gly Ile Ser 
145                 150                 155                 160 


Val Ala Val Leu Leu Ala Leu Leu Gly Ile Asn Leu Ala Gly Val Lys 
                165                 170                 175     


Trp Ile Ile Arg Leu Gln Leu Leu Leu Leu Leu Leu Leu Ala Val Ser 
            180                 185                 190         


Thr Leu Asp Phe Val Val Gly Ser Phe Thr His Leu Asp Pro Glu His 
        195                 200                 205             


Gly Phe Ile Gly Tyr Ser Pro Glu Leu Leu Gln Ser Asn Ile Leu Pro 
    210                 215                 220                 


Glu Tyr Ser Pro Gly Glu Ser Phe Phe Thr Val Phe Gly Val Phe Phe 
225                 230                 235                 240 


Pro Ala Ala Thr Gly Val Met Ala Gly Phe Asn Met Gly Gly Asp Leu 
                245                 250                 255     


Arg Asp Pro Ala Asp Ser Val Pro Leu Gly Ser Leu Ala Ala Val Gly 
            260                 265                 270         


Val Ser Trp Phe Leu Tyr Ile Ile Phe Ala Phe Leu Leu Gly Ala Val 
        275                 280                 285             


Cys Thr Arg Glu Ala Leu Arg Ser Asp Phe Leu Ile Ala Glu Lys Val 
    290                 295                 300                 


Ser Leu Val Gly Phe Leu Phe Leu Leu Gly Leu Tyr Ile Ser Ser Leu 
305                 310                 315                 320 


Ala Ser Cys Met Gly Gly Leu Tyr Gly Ala Pro Arg Ile Leu Gln Cys 
                325                 330                 335     


Ile Ala Gln Asp Lys Val Ile Pro Ala Leu Ala Phe Leu Ala Asn Gly 
            340                 345                 350         


Lys Gly Pro Asn Lys Thr Pro Val Ala Ala Ile Cys Leu Thr Ser Leu 
        355                 360                 365             


Val Thr Met Ala Phe Val Leu Val Gly Gln Val Asn Val Leu Ala Pro 
    370                 375                 380                 


Val Val Thr Ile Asn Phe Met Leu Thr Tyr Ile Met Val Asp Tyr Ser 
385                 390                 395                 400 


Tyr Phe Ala Leu Ser Met Ala His Cys Gly Leu Ala Pro Ser Pro Glu 
                405                 410                 415     


Pro Val Pro Arg Gln Gly Pro Asp Thr Leu His Cys Ser Glu His Leu 
            420                 425                 430         


Leu Gln Asp Arg Ala Pro Ser Tyr Gly Ser Asp Val Pro Ala Arg Ser 
        435                 440                 445             


Leu Ser Glu Gly Thr Leu Leu Glu Phe Thr Lys Asp Met Asp Gln Phe 
    450                 455                 460                 


Leu Gln Pro Ile Glu Glu Leu Glu Ser Arg Gln Leu Gly Ser Arg Glu 
465                 470                 475                 480 


Gly Asn Asn Pro Lys Asn Gln Lys Arg Lys Gly Lys Lys Gly Ala Lys 
                485                 490                 495     


Gln Thr Leu Gln Asp Ser Phe Leu Leu Asp Pro Gly Ser Pro Leu Ser 
            500                 505                 510         


Phe Pro Thr Arg Thr Ser Glu Arg Leu Ser Val Ala Phe Cys Gly Glu 
        515                 520                 525             


Gln Glu Ser Tyr Gln Lys Gln Gln Thr Ser Arg Ser Glu Ser His Asp 
    530                 535                 540                 


His Leu Val Pro Asp Leu Arg Asn Gln Pro Arg Val Asn Arg Glu Asp 
545                 550                 555                 560 


Phe Phe Leu Lys Cys Arg Leu Gln Glu Gln Glu Ile Gln Arg Arg Pro 
                565                 570                 575     


Ser Val Phe Tyr Ala Cys Met Cys Asn Pro Trp Val Ser Leu Leu Gly 
            580                 585                 590         


Ala Leu Ala Ser Leu Leu Ile Met Phe Val Ile Gln Trp Leu Tyr Thr 
        595                 600                 605             


Leu Ala Ser Met Gly Val Ala Ala Leu Val Tyr Phe Tyr Ile Gly Gln 
    610                 615                 620                 


Ala Ser Pro Gly Leu Tyr Leu Gly Ser Ala Ser Asn Phe Ser Phe Phe 
625                 630                 635                 640 


Gln Trp Met Lys Ser Phe Leu Val Pro Ser Cys Arg Ser Leu Arg Ser 
                645                 650                 655     


Ala Gln Glu Gln Ile Ile Leu Ala Pro Ser Pro Ala Lys Val Asp Met 
            660                 665                 670         


Ala Met Thr Gln Leu Thr Gln Asp Asn Ala Asp Phe Ala Thr Arg Asp 
        675                 680                 685             


Arg Tyr His His Ser Ser Phe Leu Ser Arg Glu Gln Leu Met Pro Pro 
    690                 695                 700                 


Tyr 
705 


<210>  13
<211>  667
<212>  PRT
<213>  Mus musculus

<400>  13

Met Ala Gln Arg Ser Pro Gln Glu Leu Phe His Glu Ala Ala Gln Gln 
1               5                   10                  15      


Gly Ile Leu Ala Gln Pro Gln Pro Trp Trp Lys Ile Gln Leu Phe Met 
            20                  25                  30          


Trp Glu Pro Val Leu Phe Gly Thr Trp Asp Gly Val Phe Thr Ser Cys 
        35                  40                  45              


Met Ile Asn Ile Phe Gly Val Val Leu Phe Leu Arg Thr Gly Trp Leu 
    50                  55                  60                  


Val Gly Asn Thr Gly Val Leu Leu Gly Leu Leu Leu Val Ser Phe Val 
65                  70                  75                  80  


Val Leu Val Ala Leu Ile Thr Val Leu Ser Gly Ile Gly Val Ala Glu 
                85                  90                  95      


His Gly Gly Ile Ser Ser Gly Gly Val Tyr Ser Met Ile Ser Ser Val 
            100                 105                 110         


Leu Gly Gly Gln Met Gly Gly Thr Val Gly Leu Leu Tyr Val Phe Gly 
        115                 120                 125             


Gln Cys Val Ala Gly Ala Met Tyr Ile Thr Gly Phe Ala Glu Ser Ile 
    130                 135                 140                 


Ser Asp Leu Leu Gly Leu Gly Asp Ile Trp Ala Val Arg Gly Ile Ser 
145                 150                 155                 160 


Val Ala Val Leu Leu Ala Leu Leu Gly Ile Asn Leu Ala Gly Val Lys 
                165                 170                 175     


Trp Ile Ile Arg Leu Gln Leu Leu Leu Leu Leu Leu Leu Ala Val Ser 
            180                 185                 190         


Thr Leu Asp Phe Val Val Gly Ser Phe Thr His Leu Asp Pro Gly Val 
        195                 200                 205             


Met Ala Gly Phe Asn Met Gly Gly Asp Leu Arg Asp Pro Ala Asp Ser 
    210                 215                 220                 


Val Pro Leu Gly Ser Leu Ala Ala Val Gly Val Ser Trp Phe Leu Tyr 
225                 230                 235                 240 


Ile Ile Phe Ala Phe Leu Leu Gly Ala Val Cys Thr Arg Glu Ala Leu 
                245                 250                 255     


Arg Ser Asp Phe Leu Ile Ala Glu Lys Val Ser Leu Val Gly Phe Leu 
            260                 265                 270         


Phe Leu Leu Gly Leu Tyr Ile Ser Ser Leu Ala Ser Cys Met Gly Gly 
        275                 280                 285             


Leu Tyr Gly Ala Pro Arg Ile Leu Gln Cys Ile Ala Gln Asp Lys Val 
    290                 295                 300                 


Ile Pro Ala Leu Ala Phe Leu Ala Asn Gly Lys Gly Pro Asn Lys Thr 
305                 310                 315                 320 


Pro Val Ala Ala Ile Cys Leu Thr Ser Leu Val Thr Met Ala Phe Val 
                325                 330                 335     


Leu Val Gly Gln Val Asn Val Leu Ala Pro Val Val Thr Ile Asn Phe 
            340                 345                 350         


Met Leu Thr Tyr Ile Met Val Asp Tyr Ser Tyr Phe Ala Leu Ser Met 
        355                 360                 365             


Ala His Cys Gly Leu Ala Pro Ser Pro Glu Pro Val Pro Arg Gln Gly 
    370                 375                 380                 


Pro Asp Thr Leu His Cys Ser Glu His Leu Leu Gln Asp Arg Ala Pro 
385                 390                 395                 400 


Ser Tyr Gly Ser Asp Val Pro Ala Arg Ser Leu Ser Glu Gly Thr Leu 
                405                 410                 415     


Leu Glu Phe Thr Lys Asp Met Asp Gln Phe Leu Gln Pro Ile Glu Glu 
            420                 425                 430         


Leu Glu Ser Arg Gln Leu Gly Ser Arg Glu Gly Asn Asn Pro Lys Asn 
        435                 440                 445             


Gln Lys Arg Lys Gly Lys Lys Gly Ala Lys Gln Thr Leu Gln Asp Ser 
    450                 455                 460                 


Phe Leu Leu Asp Pro Gly Ser Pro Leu Ser Phe Pro Thr Arg Thr Ser 
465                 470                 475                 480 


Glu Arg Leu Ser Val Ala Phe Cys Gly Glu Gln Glu Ser Tyr Gln Lys 
                485                 490                 495     


Gln Gln Thr Ser Arg Ser Glu Ser His Asp His Leu Val Pro Asp Leu 
            500                 505                 510         


Arg Asn Gln Pro Arg Val Asn Arg Glu Asp Phe Phe Leu Lys Cys Arg 
        515                 520                 525             


Leu Gln Glu Gln Glu Ile Gln Arg Arg Pro Ser Val Phe Tyr Ala Cys 
    530                 535                 540                 


Met Cys Asn Pro Trp Val Ser Leu Leu Gly Ala Leu Ala Ser Leu Leu 
545                 550                 555                 560 


Ile Met Phe Val Ile Gln Trp Leu Tyr Thr Leu Ala Ser Met Gly Val 
                565                 570                 575     


Ala Ala Leu Val Tyr Phe Tyr Ile Gly Gln Ala Ser Pro Gly Leu Tyr 
            580                 585                 590         


Leu Gly Ser Ala Ser Asn Phe Ser Phe Phe Gln Trp Met Lys Ser Phe 
        595                 600                 605             


Leu Val Pro Ser Cys Arg Ser Leu Arg Ser Ala Gln Glu Gln Ile Ile 
    610                 615                 620                 


Leu Ala Pro Ser Pro Ala Lys Val Asp Met Ala Met Thr Gln Leu Thr 
625                 630                 635                 640 


Gln Asp Asn Ala Asp Phe Ala Thr Arg Asp Arg Tyr His His Ser Ser 
                645                 650                 655     


Phe Leu Ser Arg Glu Gln Leu Met Pro Pro Tyr 
            660                 665         


<210>  14
<211>  592
<212>  PRT
<213>  Mus musculus

<400>  14

Met Ala Gln Arg Ser Pro Gln Glu Leu Phe His Glu Ala Ala Gln Gln 
1               5                   10                  15      


Cys Val Ala Gly Ala Met Tyr Ile Thr Gly Phe Ala Glu Ser Ile Ser 
            20                  25                  30          


Asp Leu Leu Gly Leu Gly Asp Ile Trp Ala Val Arg Gly Ile Ser Val 
        35                  40                  45              


Ala Val Leu Leu Ala Leu Leu Gly Ile Asn Leu Ala Gly Val Lys Trp 
    50                  55                  60                  


Ile Ile Arg Leu Gln Leu Leu Leu Leu Leu Leu Leu Ala Val Ser Thr 
65                  70                  75                  80  


Leu Asp Phe Val Val Gly Ser Phe Thr His Leu Asp Pro Glu His Gly 
                85                  90                  95      


Phe Ile Gly Tyr Ser Pro Glu Leu Leu Gln Ser Asn Ile Leu Pro Glu 
            100                 105                 110         


Tyr Ser Pro Gly Glu Ser Phe Phe Thr Val Phe Gly Val Phe Phe Pro 
        115                 120                 125             


Ala Ala Thr Gly Val Met Ala Gly Phe Asn Met Gly Gly Asp Leu Arg 
    130                 135                 140                 


Asp Pro Ala Asp Ser Val Pro Leu Gly Ser Leu Ala Ala Val Gly Val 
145                 150                 155                 160 


Ser Trp Phe Leu Tyr Ile Ile Phe Ala Phe Leu Leu Gly Ala Val Cys 
                165                 170                 175     


Thr Arg Glu Ala Leu Arg Ser Asp Phe Leu Ile Ala Glu Lys Val Ser 
            180                 185                 190         


Leu Val Gly Phe Leu Phe Leu Leu Gly Leu Tyr Ile Ser Ser Leu Ala 
        195                 200                 205             


Ser Cys Met Gly Gly Leu Tyr Gly Ala Pro Arg Ile Leu Gln Cys Ile 
    210                 215                 220                 


Ala Gln Asp Lys Val Ile Pro Ala Leu Ala Phe Leu Ala Asn Gly Lys 
225                 230                 235                 240 


Gly Pro Asn Lys Thr Pro Val Ala Ala Ile Cys Leu Thr Ser Leu Val 
                245                 250                 255     


Thr Met Ala Phe Val Leu Val Gly Gln Val Asn Val Leu Ala Pro Val 
            260                 265                 270         


Val Thr Ile Asn Phe Met Leu Thr Tyr Ile Met Val Asp Tyr Ser Tyr 
        275                 280                 285             


Phe Ala Leu Ser Met Ala His Cys Gly Leu Ala Pro Ser Pro Glu Pro 
    290                 295                 300                 


Val Pro Arg Gln Gly Pro Asp Thr Leu His Cys Ser Glu His Leu Leu 
305                 310                 315                 320 


Gln Asp Arg Ala Pro Ser Tyr Gly Ser Asp Val Pro Ala Arg Ser Leu 
                325                 330                 335     


Ser Glu Gly Thr Leu Leu Glu Phe Thr Lys Asp Met Asp Gln Phe Leu 
            340                 345                 350         


Gln Pro Ile Glu Glu Leu Glu Ser Arg Gln Leu Gly Ser Arg Glu Gly 
        355                 360                 365             


Asn Asn Pro Lys Asn Gln Lys Arg Lys Gly Lys Lys Gly Ala Lys Gln 
    370                 375                 380                 


Thr Leu Gln Asp Ser Phe Leu Leu Asp Pro Gly Ser Pro Leu Ser Phe 
385                 390                 395                 400 


Pro Thr Arg Thr Ser Glu Arg Leu Ser Val Ala Phe Cys Gly Glu Gln 
                405                 410                 415     


Glu Ser Tyr Gln Lys Gln Gln Thr Ser Arg Ser Glu Ser His Asp His 
            420                 425                 430         


Leu Val Pro Asp Leu Arg Asn Gln Pro Arg Val Asn Arg Glu Asp Phe 
        435                 440                 445             


Phe Leu Lys Cys Arg Leu Gln Glu Gln Glu Ile Gln Arg Arg Pro Ser 
    450                 455                 460                 


Val Phe Tyr Ala Cys Met Cys Asn Pro Trp Val Ser Leu Leu Gly Ala 
465                 470                 475                 480 


Leu Ala Ser Leu Leu Ile Met Phe Val Ile Gln Trp Leu Tyr Thr Leu 
                485                 490                 495     


Ala Ser Met Gly Val Ala Ala Leu Val Tyr Phe Tyr Ile Gly Gln Ala 
            500                 505                 510         


Ser Pro Gly Leu Tyr Leu Gly Ser Ala Ser Asn Phe Ser Phe Phe Gln 
        515                 520                 525             


Trp Met Lys Ser Phe Leu Val Pro Ser Cys Arg Ser Leu Arg Ser Ala 
    530                 535                 540                 


Gln Glu Gln Ile Ile Leu Ala Pro Ser Pro Ala Lys Val Asp Met Ala 
545                 550                 555                 560 


Met Thr Gln Leu Thr Gln Asp Asn Ala Asp Phe Ala Thr Arg Asp Arg 
                565                 570                 575     


Tyr His His Ser Ser Phe Leu Ser Arg Glu Gln Leu Met Pro Pro Tyr 
            580                 585                 590         


<210>  15
<211>  714
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Thr Gln Met Ser Gln Val Gln Glu Leu Phe His Glu Ala Ala Gln 
1               5                   10                  15      


Gln Asp Ala Leu Ala Gln Pro Gln Pro Trp Trp Lys Thr Gln Leu Phe 
            20                  25                  30          


Met Trp Glu Pro Val Leu Phe Gly Thr Trp Asp Gly Val Phe Thr Ser 
        35                  40                  45              


Cys Met Ile Asn Ile Phe Gly Val Val Leu Phe Leu Arg Thr Gly Trp 
    50                  55                  60                  


Leu Val Gly Asn Thr Gly Val Leu Leu Gly Met Phe Leu Val Ser Phe 
65                  70                  75                  80  


Val Ile Leu Val Ala Leu Val Thr Val Leu Ser Gly Ile Gly Val Gly 
                85                  90                  95      


Glu Arg Ser Ser Ile Gly Ser Gly Gly Val Tyr Ser Met Ile Ser Ser 
            100                 105                 110         


Val Leu Gly Gly Gln Thr Gly Gly Thr Ile Gly Leu Leu Tyr Val Phe 
        115                 120                 125             


Gly Gln Cys Val Ala Gly Ala Met Tyr Ile Thr Gly Phe Ala Glu Ser 
    130                 135                 140                 


Ile Ser Asp Leu Leu Gly Leu Gly Asn Ile Trp Ala Val Arg Gly Ile 
145                 150                 155                 160 


Ser Val Ala Val Leu Leu Ala Leu Leu Gly Ile Asn Leu Ala Gly Val 
                165                 170                 175     


Lys Trp Ile Ile Arg Leu Gln Leu Leu Leu Leu Phe Leu Leu Ala Val 
            180                 185                 190         


Ser Thr Leu Asp Phe Val Val Gly Ser Phe Thr His Leu Asp Pro Glu 
        195                 200                 205             


His Gly Phe Ile Gly Tyr Ser Pro Glu Leu Leu Gln Asn Asn Thr Leu 
    210                 215                 220                 


Pro Asp Tyr Ser Pro Gly Glu Ser Phe Phe Thr Val Phe Gly Val Phe 
225                 230                 235                 240 


Phe Pro Ala Ala Thr Gly Val Met Ala Gly Phe Asn Met Gly Gly Asp 
                245                 250                 255     


Leu Arg Glu Pro Ala Ala Ser Ile Pro Leu Gly Ser Leu Ala Ala Val 
            260                 265                 270         


Gly Ile Ser Trp Phe Leu Tyr Ile Ile Phe Val Phe Leu Leu Gly Ala 
        275                 280                 285             


Ile Cys Thr Arg Glu Ala Leu Arg Tyr Asp Phe Leu Ile Ala Glu Lys 
    290                 295                 300                 


Val Ser Leu Met Gly Phe Leu Phe Leu Leu Gly Leu Tyr Ile Ser Ser 
305                 310                 315                 320 


Leu Ala Ser Cys Met Gly Gly Leu Tyr Gly Ala Pro Arg Ile Leu Gln 
                325                 330                 335     


Cys Ile Ala Gln Glu Lys Val Ile Pro Ala Leu Ala Cys Leu Gly Gln 
            340                 345                 350         


Gly Lys Gly Pro Asn Lys Thr Pro Val Ala Ala Ile Cys Leu Thr Ser 
        355                 360                 365             


Leu Val Thr Met Ala Phe Val Phe Val Gly Gln Val Asn Val Leu Ala 
    370                 375                 380                 


Pro Ile Val Thr Ile Asn Phe Met Leu Thr Tyr Val Ala Val Asp Tyr 
385                 390                 395                 400 


Ser Tyr Phe Ser Leu Ser Met Cys Ser Cys Ser Leu Thr Pro Val Pro 
                405                 410                 415     


Glu Pro Val Leu Arg Glu Gly Ala Glu Gly Leu His Cys Ser Glu His 
            420                 425                 430         


Leu Leu Leu Glu Lys Ala Pro Ser Tyr Gly Ser Glu Gly Pro Ala Gln 
        435                 440                 445             


Arg Val Leu Glu Gly Thr Leu Leu Glu Phe Thr Lys Asp Met Asp Gln 
    450                 455                 460                 


Leu Leu Gln Leu Thr Arg Lys Leu Glu Ser Ser Gln Pro Arg Gln Gly 
465                 470                 475                 480 


Glu Gly Asn Arg Thr Pro Glu Ser Gln Lys Arg Lys Ser Lys Lys Ala 
                485                 490                 495     


Thr Lys Gln Thr Leu Gln Asp Ser Phe Leu Leu Asp Leu Lys Ser Pro 
            500                 505                 510         


Pro Ser Phe Pro Val Glu Ile Ser Asp Arg Leu Pro Ala Ala Ser Trp 
        515                 520                 525             


Glu Gly Gln Glu Ser Cys Trp Asn Lys Gln Thr Ser Lys Ser Glu Gly 
    530                 535                 540                 


Thr Gln Pro Glu Gly Thr Tyr Gly Glu Gln Leu Val Pro Glu Leu Cys 
545                 550                 555                 560 


Asn Gln Ser Glu Ser Ser Gly Glu Asp Phe Phe Leu Lys Ser Arg Leu 
                565                 570                 575     


Gln Glu Gln Asp Val Trp Arg Arg Ser Thr Ser Phe Tyr Thr His Met 
            580                 585                 590         


Cys Asn Pro Trp Val Ser Leu Leu Gly Ala Val Gly Ser Leu Leu Ile 
        595                 600                 605             


Met Phe Val Ile Gln Trp Val Tyr Thr Leu Val Asn Met Gly Val Ala 
    610                 615                 620                 


Ala Ile Val Tyr Phe Tyr Ile Gly Arg Ala Ser Pro Gly Leu His Leu 
625                 630                 635                 640 


Gly Ser Ala Ser Asn Phe Ser Phe Phe Arg Trp Met Arg Ser Leu Leu 
                645                 650                 655     


Leu Pro Ser Cys Arg Ser Leu Arg Ser Pro Gln Glu Gln Ile Ile Leu 
            660                 665                 670         


Ala Pro Ser Leu Ala Lys Val Asp Met Glu Met Thr Gln Leu Thr Gln 
        675                 680                 685             


Glu Asn Ala Asp Phe Ala Thr Arg Asp Arg Tyr His His Ser Ser Leu 
    690                 695                 700                 


Val Asn Arg Glu Gln Leu Met Pro His Tyr 
705                 710                 


