                         SEQUENCE LISTING

<110>  The Board of Trustees of the University of Illinois
       Lavie, Arnon
       Nguyen, Hien-Anh
       Shalk, Amanda
 
<120>  Truncated Guinea Pig L-Asparaginase Variants and Methods of Use

<130>  UIC0074WO

<150>  US 62/544,396
<151>  2017-08-11

<150>  US 62/544,411
<151>  2017-08-11

<160>  94    

<170>  PatentIn version 3.5

<210>  1
<211>  565
<212>  PRT
<213>  Cavia porcellus

<400>  1

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Lys 
        35                  40                  45              


Glu Phe Ala Gln Ala Gln Gly Leu Pro Asp His Ala Leu Ala Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile Arg Ile 
                85                  90                  95      


Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Ser Gly Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Cys Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Asn Met Glu His Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Gln 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Leu Pro Thr Ala Asp Leu His Gln Ser 
        355                 360                 365             


Ser Pro Pro Gly Ser Thr Leu Gly Gln Gly Val Ala Arg Leu Phe Ser 
    370                 375                 380                 


Leu Phe Gly Cys Gln Glu Glu Asp Ser Val Gln Asp Ala Val Met Pro 
385                 390                 395                 400 


Ser Leu Ala Leu Ala Leu Ala His Ala Gly Glu Leu Glu Ala Leu Gln 
                405                 410                 415     


Ala Leu Met Glu Leu Gly Ser Asp Leu Arg Leu Lys Asp Ser Asn Gly 
            420                 425                 430         


Gln Thr Leu Leu His Val Ala Ala Arg Asn Gly Arg Asp Gly Val Val 
        435                 440                 445             


Thr Met Leu Leu His Arg Gly Met Asp Val Asn Ala Arg Asp Arg Asp 
    450                 455                 460                 


Gly Leu Ser Pro Leu Leu Leu Ala Val Gln Gly Arg His Arg Glu Cys 
465                 470                 475                 480 


Ile Arg Leu Leu Arg Lys Ala Gly Ala Cys Leu Ser Pro Gln Asp Leu 
                485                 490                 495     


Lys Asp Ala Gly Thr Glu Leu Cys Arg Leu Ala Ser Arg Ala Asp Met 
            500                 505                 510         


Glu Gly Leu Gln Ala Trp Gly Gln Ala Gly Ala Asp Leu Gln Gln Pro 
        515                 520                 525             


Gly Tyr Asp Gly Arg Ser Ala Leu Cys Val Ala Glu Ala Ala Gly Asn 
    530                 535                 540                 


Gln Glu Val Leu Ala Leu Leu Arg Asn Leu Ala Leu Val Gly Pro Glu 
545                 550                 555                 560 


Val Pro Pro Ala Ile 
                565 


<210>  2
<211>  573
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Arg Ala Val Gly Pro Glu Arg Arg Leu Leu Ala Val Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Ile Gly Met Arg Ser Glu Leu Gly Val Leu Val Pro Gly 
            20                  25                  30          


Thr Gly Leu Ala Ala Ile Leu Arg Thr Leu Pro Met Phe His Asp Glu 
        35                  40                  45              


Glu His Ala Arg Ala Arg Gly Leu Ser Glu Asp Thr Leu Val Leu Pro 
    50                  55                  60                  


Pro Ala Ser Arg Asn Gln Arg Ile Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Phe Asp Ser Ser Asp Met Thr Ile Ala Glu Trp Val Cys Leu 
                85                  90                  95      


Ala Gln Thr Ile Lys Arg His Tyr Glu Gln Tyr His Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu Gln Lys Thr Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile His Ala Leu Trp Ser Asp Gly Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Met Ala Gly Gln Tyr Val Ile Pro Glu Val Cys Leu Phe Phe 
                165                 170                 175     


Gln Asn Gln Leu Phe Arg Gly Asn Arg Ala Thr Lys Val Asp Ala Arg 
            180                 185                 190         


Arg Phe Ala Ala Phe Cys Ser Pro Asn Leu Leu Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Ile Thr Ile Asn Arg Glu Leu Val Arg Lys Val Asp Gly 
    210                 215                 220                 


Lys Ala Gly Leu Val Val His Ser Ser Met Glu Gln Asp Val Gly Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ala Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Met Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Thr Lys Pro Asp Leu Leu Gln Glu Leu Arg Val Ala Thr Glu 
        275                 280                 285             


Arg Gly Leu Val Ile Val Asn Cys Thr His Cys Leu Gln Gly Ala Val 
    290                 295                 300                 


Thr Thr Asp Tyr Ala Ala Gly Met Ala Met Ala Gly Ala Gly Val Ile 
305                 310                 315                 320 


Ser Gly Phe Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr 
                325                 330                 335     


Val Leu Gly Gln Pro Gly Leu Ser Leu Asp Val Arg Lys Glu Leu Leu 
            340                 345                 350         


Thr Lys Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg 
        355                 360                 365             


Arg Pro Ser Leu Gln Gly Asn Thr Leu Gly Gly Gly Val Ser Trp Leu 
    370                 375                 380                 


Leu Ser Leu Ser Gly Ser Gln Glu Ala Asp Ala Leu Arg Asn Ala Leu 
385                 390                 395                 400 


Val Pro Ser Leu Ala Cys Ala Ala Ala His Ala Gly Asp Val Glu Ala 
                405                 410                 415     


Leu Gln Ala Leu Val Glu Leu Gly Ser Asp Leu Gly Leu Val Asp Phe 
            420                 425                 430         


Asn Gly Gln Thr Pro Leu His Ala Ala Ala Arg Gly Gly His Thr Glu 
        435                 440                 445             


Ala Val Thr Met Leu Leu Gln Arg Gly Val Asp Val Asn Thr Arg Asp 
    450                 455                 460                 


Thr Asp Gly Phe Ser Pro Leu Leu Leu Ala Val Arg Gly Arg His Pro 
465                 470                 475                 480 


Gly Val Ile Gly Leu Leu Arg Glu Ala Gly Ala Ser Leu Ser Thr Gln 
                485                 490                 495     


Glu Leu Glu Glu Ala Gly Thr Glu Leu Cys Arg Leu Ala Tyr Arg Ala 
            500                 505                 510         


Asp Leu Glu Gly Leu Gln Val Trp Trp Gln Ala Gly Ala Asp Leu Gly 
        515                 520                 525             


Gln Pro Gly Tyr Asp Gly His Ser Ala Leu His Val Ala Glu Ala Ala 
    530                 535                 540                 


Gly Asn Leu Ala Val Val Ala Phe Leu Gln Ser Leu Glu Gly Ala Val 
545                 550                 555                 560 


Gly Ala Gln Ala Pro Cys Pro Glu Val Leu Pro Gly Val 
                565                 570             


<210>  3
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Lys 
        35                  40                  45              


Glu Phe Ala Gln Ala Gln Gly Leu Pro Asp His Ala Leu Ala Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile Arg Ile 
                85                  90                  95      


Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Ser Gly Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Cys Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Asn Met Glu His Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Gln 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr 
        355                 


<210>  4
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Lys 
        35                  40                  45              


Glu Phe Ala Gln Ala Gln Gly Leu Pro Asp His Ala Leu Ala Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile Arg Ile 
                85                  90                  95      


Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Ser Gly Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Cys Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Asn Met Glu His Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Gln 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Leu Pro Thr Ala Asp Leu His Gln 
        355                 360                 365         


<210>  5
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Lys 
        35                  40                  45              


Glu Phe Ala Gln Ala Gln Gly Leu Pro Asp His Ala Leu Ala Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile Arg Ile 
                85                  90                  95      


Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Ser Gly Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Cys Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Asn Met Glu His Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Gln 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Leu Pro Thr Ala Asp Leu His Gln Ser 
        355                 360                 365             


Ser 
    


<210>  6
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Lys 
        35                  40                  45              


Glu Phe Ala Gln Ala Gln Gly Leu Pro Asp His Ala Leu Ala Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile Arg Ile 
                85                  90                  95      


Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Ser Gly Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Cys Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Asn Met Glu His Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Gln 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Leu Pro Thr Ala Asp Leu His Gln Ser 
        355                 360                 365             


Ser Pro Pro Gly Ser Thr 
    370                 


<210>  7
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Lys 
        35                  40                  45              


Glu Phe Ala Gln Ala Gln Gly Leu Pro Asp His Ala Leu Ala Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile Arg Ile 
                85                  90                  95      


Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Ser Gly Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Cys Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Asn Met Glu His Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Gln 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Leu Pro Thr Ala Asp Leu His Gln Ser 
        355                 360                 365             


Ser Pro Pro Gly Ser Thr Leu Gly Gln Gly Val Ala Arg Leu Phe Ser 
    370                 375                 380                 


<210>  8
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Lys 
        35                  40                  45              


Glu Phe Ala Gln Ala Gln Gly Leu Pro Asp His Ala Leu Ala Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile Arg Ile 
                85                  90                  95      


Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Ser Gly Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Cys Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Asn Met Glu His Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Gln 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Leu Pro Thr Ala Asp Leu His Gln Ser 
        355                 360                 365             


Ser Pro Pro Gly Ser Thr Leu Gly Gln Gly Val Ala Arg Leu Phe Ser 
    370                 375                 380                 


Leu Phe Gly Cys Gln Glu Glu Asp 
385                 390         


<210>  9
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Lys 
        35                  40                  45              


Glu Phe Ala Gln Ala Gln Gly Leu Pro Asp His Ala Leu Ala Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile Arg Ile 
                85                  90                  95      


Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Ser Gly Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Cys Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Asn Met Glu His Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Gln 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Leu Pro Thr Ala Asp Leu His Gln Ser 
        355                 360                 365             


Ser Pro Pro Gly Ser Thr Leu Gly Gln Gly Val Ala Arg Leu Phe Ser 
    370                 375                 380                 


Leu Phe Gly Cys Gln Glu Glu Asp Ser Val Gln Asp 
385                 390                 395     


<210>  10
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  10
aacgtcggat ccttaaatag ccggcgggac ttc                                    33


<210>  11
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  11
atggcacgcg cttcgggctc ggaa                                              24


<210>  12
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  12
ccagattacg cagcagagc                                                    19


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  13
gctcgtgctg tgggtccgga a                                                 21


<210>  14
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  14
gacacccggc agcacttc                                                     18


<210>  15
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  15
ctgatgcagg tctgccgtcg gcagcgtcat ttcaccgcgc aggt                        44


<210>  16
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  16
aaggacctgc gcggtgaaat gacgctgccg acggcagacc tgc                         43


<210>  17
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  17
gcgacgttct tccacagacg gcggggtcat ttcaccacgc agatc                       45


<210>  18
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  18
aaagatctgc gtggtgaaat gaccccgccg tctgtggaag aacg                        44


<210>  19
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  n is a, c, g, or t

<400>  19
tacaccggcg gcaccattgg cnnknnkagt gagctcggcg tgcttgtg                    48


<210>  20
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is a, c, g, or t

<400>  20
cacaagcacg ccgagctcac tmnnmnngcc aatggtgccg ccggtgta                    48


<210>  21
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  n is a, c, g, or t

<400>  21
ctggagtgcc agcccctctt cnnktccnnk gacatgacca tcgctgagtg g                51


<210>  22
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  n is a, c, g, or t

<400>  22
ccactcagcg atggtcatgt cmnnggamnn gaagaggggc tggcactcca g                51


<210>  23
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  n is a, c, g, or t

<400>  23
cagtaccacg gctttgtggt catcnnknnk accgacacca tggcctttgc tgcc             54


<210>  24
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  n is a, c, g, or t

<400>  24
ggcagcaaag gccatggtgt cggtmnnmnn gatgaccaca aagccgtggt actg             54


<210>  25
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (30)..(31)
<223>  n is a, c, g, or t

<400>  25
agaagactgt catcctcact gggnnknnkn nkcccatcca tgccctgtgg agc              53


<210>  26
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  n is a, c, g, or t

<400>  26
gctccacagg gcatgatggg mnnmnnmnnc ccagtgagga tgacagtctt ct               52


<210>  27
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  n is a, c, g, or t

<400>  27
gcaaccgggc aaccaaggta gacnnknnka ggttcgcagc tttctgctcc cc               52


<210>  28
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  n is a, c, g, or t

<400>  28
ggggagcaga aagctgcgaa cctmnnmnng tctaccttgg ttgcccggtt gc               52


<210>  29
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  n is a, c, g, or t

<400>  29
tcatccacgg caccgacnnk atggccnnkg ctgcctcgat gctgtcc                     47


<210>  30
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  n is a, c, g, or t

<400>  30
ggacagcatc gaggcagcmn nggccatmnn gtcggtgccg tggatga                     47


<210>  31
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (31)..(32)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (43)..(44)
<223>  n is a, c, g, or t

<400>  31
tccagtgaca tgaccatcnn kgagtgggtt nnkcttgccc agnnkatcaa gaggcactac       60

gag                                                                     63


<210>  32
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (44)..(45)
<223>  n is a, c, g, or t

<400>  32
ctcgtagtgc ctcttgatmn nctgggcaag mnnaacccac tcmnngatgg tcatgtcact       60

gga                                                                     63


<210>  33
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  n is a, c, g, or t

<400>  33
ggcggcacca ttggcatgnn kagtnnknnk ggcgtgcttg tgcccggg                    48


<210>  34
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  n is a, c, g, or t

<400>  34
cccgggcaca agcacgccmn nmnnactmnn catgccaatg gtgccgcc                    48


<210>  35
<211>  1722
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  35
atggctcgtg ctgtgggtcc ggaacgccgc ctgctggctg tctatacggg tggtacgatt       60

ggtatgcgct ctgaactggg tgtcctggtg ccgggtaccg gtctggcagc aattctgcgt      120

acgctgccga tgtttcatga tgaagaacac gcacgtgcac gcggtctgtc ggaagacacc      180

ctggtgctgc cgccggcaag ccgtaaccag cgcatcctgt ataccgttct ggaatgccaa      240

ccgctgtttg atagctctga catgaccatt gccgaatggg tttgtctggc acagacgatc      300

aaacgtcatt atgaacaata ccacggtttc gtggttattc atggcaccga tacgatggcc      360

tttgcagctt ccatgctgtc attcatgctg gaaaacctgc agaagaccgt tattctgacg      420

ggcgctcaag tcccgatcca cgcactgtgg agcgacggtc gcgaaaatct gctgggcgcc      480

ctgctgatgg caggccagta tgtcatcccg gaagtgtgcc tgtttttcca gaaccaactg      540

ttccgtggta atcgcgctac caaagtcgat gcgcgtcgct ttgcggcctt ctgtagcccg      600

aacctgctgc cgctggctac cgttggtgca gatattacga tcaatcgtga actggtgcgc      660

aaagttgacg gcaaggcagg tctggtcgtg catagttcca tggaacagga tgtcggcctg      720

ctgcgtctgt acccgggtat tccggcagct ctggtgcgtg cctttctgca gccgccgctg      780

aaaggtgttg tcatggaaac cttcggttct ggcaacggtc cgacgaagcc ggatctgctg      840

caggaactgc gtgtggcaac cgaacgcggc ctggtcattg tgaattgcac gcactgtctg      900

caaggcgcag ttaccacgga ttatgcagcc ggtatggcaa tggctggtgc gggtgtcatc      960

tcgggttttg acatgaccag cgaagcagct ctggcgaaac tgtcctacgt tctgggccag     1020

ccgggtctgt cactggatgt ccgtaaagaa ctgctgacca aggacctgcg cggtgaaatg     1080

acgccgccgt ctgtggaaga acgtcgcccg agtctgcagg gtaacaccct gggcggtggc     1140

gtttcttggc tgctgtcact gtcgggcagc caagaagccg atgcactgcg caatgcactg     1200

gtgccgagtc tggcatgcgc agcagcacat gcaggtgacg tggaagctct gcaggcgctg     1260

gttgaactgg gttccgatct gggcctggtg gactttaacg gtcaaacccc gctgcatgct     1320

gcagcacgtg gtggccacac cgaagcagtt acgatgctgc tgcagcgtgg cgttgatgtc     1380

aatacccgcg atacggacgg tttcagtccg ctgctgctgg cagtccgtgg tcgtcatccg     1440

ggcgtgatcg gtctgctgcg cgaagctggt gcgtctctga gtacccagga actggaagaa     1500

gcgggcacgg aactgtgtcg tctggcctat cgcgcagatc tggaaggcct gcaagtgtgg     1560

tggcaagcag gtgcagatct gggtcagccg ggttacgacg gtcatagcgc cctgcacgtt     1620

gcagaagcag ctggtaatct ggctgtggtt gcgtttctgc aaagtctgga aggtgccgtc     1680

ggtgcccaag cgccgtgccc ggaagtgctg ccgggtgtct aa                        1722


<210>  36
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  36
atggcacgcg cttcgggctc ggaacgtcat ctgctgctga tctacacggg tggcacgctg       60

ggtatgcaat ccaagggtgg tgttctggtc ccgggtccgg gtctggtgac cctgctgcgt      120

acgctgccga tgtttcatga taaagaattc gcacaggcac aaggcctgcc ggaccatgct      180

ctggcgctgc cgccggcctc tcacggtccg cgcgtgctgt ataccgttct ggaatgccag      240

ccgctgctgg atagctctga catgacgatt gatgactgga ttcgtatcgc gaagattatc      300

gaacgccatt atgaacagta ccaaggtttt gtggttatcc acggcaccga tacgatggct      360

tcaggcgcgt cgatgctgag cttcatgctg gaaaacctgc acaaaccggt gattctgacc      420

ggtgcccagg tcccgatccg tgtgctgtgg aacgatgcac gcgaaaatct gctgggtgcc      480

ctgctggttg caggccagta tattatcccg gaagtctgcc tgtttatgaa ctcgcaactg      540

ttccgtggca atcgcgtcac gaaggtggat agccagaaat ttgaagcatt ctgttctccg      600

aacctgagtc cgctggctac cgttggtgcg gatgtcacga ttgcgtggga cctggttcgt      660

aaagtcaagt ggaaagatcc gctggtcgtg cattccaata tggaacacga cgtcgcactg      720

ctgcgtctgt acccgggcat cccggctagc ctggttcgtg cgtttctgca gccgccgctg      780

aagggtgttg tcctggaaac cttcggctcc ggtaatggcc cgtcaaaacc ggatctgctg      840

caggaactgc gtgcagcagc acaacgcggc ctgattatgg tgaactgctc gcagtgtctg      900

cgcggtagcg ttaccccggg ttatgccacg agcctggcag gtgcaaatat cgtgtctggc      960

ctggatatga ccagtgaagc tgcgctggcg aagctgtctt acgttctggg cctgccggaa     1020

ctgagtctgg aacgtcgcca ggaactgctg gctaaagatc tgcgtggtga aatgaccctg     1080

ccgacggcag acctgcatca gagttccccg ccgggctcca ccctgggtca aggcgtggcc     1140

cgcctgtttt cactgttcgg ttgtcaggaa gaagattcgg tgcaagacgc agttatgccg     1200

agcctggctc tggcactggc acacgcaggt gaactggaag ccctgcaagc actgatggaa     1260

ctgggttccg atctgcgtct gaaagactca aacggccaga ccctgctgca tgttgccgca     1320

cgtaatggtc gcgatggcgt ggttacgatg ctgctgcacc gcggtatgga cgtgaacgca     1380

cgtgatcgtg acggtctgtc accgctgctg ctggcagttc aaggtcgtca tcgcgaatgc     1440

attcgtctgc tgcgcaaggc tggcgcgtgt ctgtctccgc aggatctgaa agacgcgggt     1500

accgaactgt gccgtctggc tagtcgcgcg gatatggaag gtctgcaggc atggggtcaa     1560

gcaggtgcag atctgcagca accgggttac gacggccgta gtgccctgtg tgtggcagaa     1620

gctgcgggta atcaggaagt gctggctctg ctgcgtaatc tggctctggt tggcccggaa     1680

gtcccgccgg ctatttaa                                                   1698


<210>  37
<211>  571
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Lys 
        35                  40                  45              


Glu Phe Ala Gln Ala Gln Gly Leu Pro Asp His Ala Leu Ala Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile Arg Ile 
                85                  90                  95      


Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Ser Gly Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Cys Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Ser Met Glu Gln Asp Val Gly Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Glu 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg Arg Pro 
        355                 360                 365             


Ser Leu Gln Gly Asn Thr Leu Gly Gly Gly Val Ser Trp Leu Leu Ser 
    370                 375                 380                 


Leu Ser Gly Ser Gln Glu Ala Asp Ala Leu Arg Asn Ala Leu Val Pro 
385                 390                 395                 400 


Ser Leu Ala Cys Ala Ala Ala His Ala Gly Asp Val Glu Ala Leu Gln 
                405                 410                 415     


Ala Leu Val Glu Leu Gly Ser Asp Leu Gly Leu Val Asp Phe Asn Gly 
            420                 425                 430         


Gln Thr Pro Leu His Ala Ala Ala Arg Gly Gly His Thr Glu Ala Val 
        435                 440                 445             


Thr Met Leu Leu Gln Arg Gly Val Asp Val Asn Thr Arg Asp Thr Asp 
    450                 455                 460                 


Gly Phe Ser Pro Leu Leu Leu Ala Val Arg Gly Arg His Pro Gly Val 
465                 470                 475                 480 


Ile Gly Leu Leu Arg Glu Ala Gly Ala Ser Leu Ser Thr Gln Glu Leu 
                485                 490                 495     


Glu Glu Ala Gly Thr Glu Leu Cys Arg Leu Ala Tyr Arg Ala Asp Leu 
            500                 505                 510         


Glu Gly Leu Gln Val Trp Trp Gln Ala Gly Ala Asp Leu Gly Gln Pro 
        515                 520                 525             


Gly Tyr Asp Gly His Ser Ala Leu His Val Ala Glu Ala Ala Gly Asn 
    530                 535                 540                 


Leu Ala Val Val Ala Phe Leu Gln Ser Leu Glu Gly Ala Val Gly Ala 
545                 550                 555                 560 


Gln Ala Pro Cys Pro Glu Val Leu Pro Gly Val 
                565                 570     


<210>  38
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  38

Met Ala Arg Ala Val Gly Pro Glu Arg Arg Leu Leu Ala Val Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Ile Gly Met Arg Ser Glu Leu Gly Val Leu Val Pro Gly 
            20                  25                  30          


Thr Gly Leu Ala Ala Ile Leu Arg Thr Leu Pro Met Phe His Asp Glu 
        35                  40                  45              


Glu His Ala Arg Ala Arg Gly Leu Ser Glu Asp Thr Leu Val Leu Pro 
    50                  55                  60                  


Pro Ala Ser Arg Asn Gln Arg Ile Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Phe Asp Ser Ser Asp Met Thr Ile Ala Glu Trp Val Cys Leu 
                85                  90                  95      


Ala Gln Thr Ile Lys Arg His Tyr Glu Gln Tyr His Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu Gln Lys Thr Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile His Ala Leu Trp Ser Asp Gly Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Met Ala Gly Gln Tyr Val Ile Pro Glu Val Cys Leu Phe Phe 
                165                 170                 175     


Gln Asn Gln Leu Phe Arg Gly Asn Arg Ala Thr Lys Val Asp Ala Arg 
            180                 185                 190         


Arg Phe Ala Ala Phe Cys Ser Pro Asn Leu Leu Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Ile Thr Ile Asn Arg Glu Leu Val Arg Lys Val Asp Gly 
    210                 215                 220                 


Lys Ala Gly Leu Val Val His Ser Ser Met Glu Gln Asp Val Gly Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ala Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Met Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Thr Lys Pro Asp Leu Leu Gln Glu Leu Arg Val Ala Thr Glu 
        275                 280                 285             


Arg Gly Leu Val Ile Val Asn Cys Thr His Cys Leu Gln Gly Ala Val 
    290                 295                 300                 


Thr Thr Asp Tyr Ala Ala Gly Met Ala Met Ala Gly Ala Gly Val Ile 
305                 310                 315                 320 


Ser Gly Phe Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr 
                325                 330                 335     


Val Leu Gly Gln Pro Gly Leu Ser Leu Asp Val Arg Lys Glu Leu Leu 
            340                 345                 350         


Thr Lys Asp Leu Arg Gly Glu Met Thr Leu Pro Thr Ala Asp Leu His 
        355                 360                 365             


Gln Ser Ser Pro Pro Gly Ser Thr Leu Gly Gln Gly Val Ala Arg Leu 
    370                 375                 380                 


Phe Ser Leu Phe Gly Cys Gln Glu Glu Asp Ser Val Gln Asp Ala Val 
385                 390                 395                 400 


Met Pro Ser Leu Ala Leu Ala Leu Ala His Ala Gly Glu Leu Glu Ala 
                405                 410                 415     


Leu Gln Ala Leu Met Glu Leu Gly Ser Asp Leu Arg Leu Lys Asp Ser 
            420                 425                 430         


Asn Gly Gln Thr Leu Leu His Val Ala Ala Arg Asn Gly Arg Asp Gly 
        435                 440                 445             


Val Val Thr Met Leu Leu His Arg Gly Met Asp Val Asn Ala Arg Asp 
    450                 455                 460                 


Arg Asp Gly Leu Ser Pro Leu Leu Leu Ala Val Gln Gly Arg His Arg 
465                 470                 475                 480 


Glu Cys Ile Arg Leu Leu Arg Lys Ala Gly Ala Cys Leu Ser Pro Gln 
                485                 490                 495     


Asp Leu Lys Asp Ala Gly Thr Glu Leu Cys Arg Leu Ala Ser Arg Ala 
            500                 505                 510         


Asp Met Glu Gly Leu Gln Ala Trp Gly Gln Ala Gly Ala Asp Leu Gln 
        515                 520                 525             


Gln Pro Gly Tyr Asp Gly Arg Ser Ala Leu Cys Val Ala Glu Ala Ala 
    530                 535                 540                 


Gly Asn Gln Glu Val Leu Ala Leu Leu Arg Asn Leu Ala Leu Val Gly 
545                 550                 555                 560 


Pro Glu Val Pro Pro Ala Ile 
                565         


<210>  39
<211>  571
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  39

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Lys 
        35                  40                  45              


Glu Phe Ala Arg Ala Arg Gly Leu Ser Glu Asp Thr Leu Val Leu Pro 
    50                  55                  60                  


Pro Ala Ser Arg Asn Gln Arg Ile Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile Arg Ile 
                85                  90                  95      


Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Cys Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Ser Met Glu Gln Asp Val Gly Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Glu 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg Arg Pro 
        355                 360                 365             


Ser Leu Gln Gly Asn Thr Leu Gly Gly Gly Val Ser Trp Leu Leu Ser 
    370                 375                 380                 


Leu Ser Gly Ser Gln Glu Ala Asp Ala Leu Arg Asn Ala Leu Val Pro 
385                 390                 395                 400 


Ser Leu Ala Cys Ala Ala Ala His Ala Gly Asp Val Glu Ala Leu Gln 
                405                 410                 415     


Ala Leu Val Glu Leu Gly Ser Asp Leu Gly Leu Val Asp Phe Asn Gly 
            420                 425                 430         


Gln Thr Pro Leu His Ala Ala Ala Arg Gly Gly His Thr Glu Ala Val 
        435                 440                 445             


Thr Met Leu Leu Gln Arg Gly Val Asp Val Asn Thr Arg Asp Thr Asp 
    450                 455                 460                 


Gly Phe Ser Pro Leu Leu Leu Ala Val Arg Gly Arg His Pro Gly Val 
465                 470                 475                 480 


Ile Gly Leu Leu Arg Glu Ala Gly Ala Ser Leu Ser Thr Gln Glu Leu 
                485                 490                 495     


Glu Glu Ala Gly Thr Glu Leu Cys Arg Leu Ala Tyr Arg Ala Asp Leu 
            500                 505                 510         


Glu Gly Leu Gln Val Trp Trp Gln Ala Gly Ala Asp Leu Gly Gln Pro 
        515                 520                 525             


Gly Tyr Asp Gly His Ser Ala Leu His Val Ala Glu Ala Ala Gly Asn 
    530                 535                 540                 


Leu Ala Val Val Ala Phe Leu Gln Ser Leu Glu Gly Ala Val Gly Ala 
545                 550                 555                 560 


Gln Ala Pro Cys Pro Glu Val Leu Pro Gly Val 
                565                 570     


<210>  40
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  40

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Glu 
        35                  40                  45              


Glu His Ala Arg Ala Arg Gly Leu Ser Glu Asp Thr Leu Val Leu Pro 
    50                  55                  60                  


Pro Ala Ser Arg Asn Gln Arg Ile Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile Arg Ile 
                85                  90                  95      


Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile His Ala Leu Trp Ser Asp Gly Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Cys Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Ser Met Glu Gln Asp Val Gly Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Met Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Thr Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Glu 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg Arg Pro 
        355                 360                 365             


Ser Leu Gln Gly Asn Thr Leu Gly Gly Gly Val Ser Trp Leu Leu Ser 
    370                 375                 380                 


Leu Ser Gly Ser Gln Glu Ala Asp Ala Leu Arg Asn Ala Leu Val Pro 
385                 390                 395                 400 


Ser Leu Ala Cys Ala Ala Ala His Ala Gly Asp Val Glu Ala Leu Gln 
                405                 410                 415     


Ala Leu Val Glu Leu Gly Ser Asp Leu Gly Leu Val Asp Phe Asn Gly 
            420                 425                 430         


Gln Thr Pro Leu His Ala Ala Ala Arg Gly Gly His Thr Glu Ala Val 
        435                 440                 445             


Thr Met Leu Leu Gln Arg Gly Val Asp Val Asn Thr Arg Asp Thr Asp 
    450                 455                 460                 


Gly Phe Ser Pro Leu Leu Leu Ala Val Arg Gly Arg His Pro Gly Val 
465                 470                 475                 480 


Ile Gly Leu Leu Arg Glu Ala Gly Ala Ser Leu Ser Thr Gln Glu Leu 
                485                 490                 495     


Glu Glu Ala Gly Thr Glu Leu Cys Arg Leu Ala Tyr Arg Ala Asp Leu 
            500                 505                 510         


Glu 
    


<210>  41
<211>  571
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  41

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Glu 
        35                  40                  45              


Glu His Ala Arg Ala Arg Gly Leu Ser Glu Asp Thr Leu Val Leu Pro 
    50                  55                  60                  


Pro Ala Ser Arg Asn Gln Arg Ile Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Phe Asp Ser Ser Asp Met Thr Ile Ala Glu Trp Val Cys Leu 
                85                  90                  95      


Ala Gln Thr Ile Lys Arg His Tyr Glu Gln Tyr His Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile His Ala Leu Trp Ser Asp Gly Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Met Ala Gly Gln Tyr Val Ile Pro Glu Val Cys Leu Phe Phe 
                165                 170                 175     


Gln Asn Gln Leu Phe Arg Gly Asn Arg Ala Thr Lys Val Asp Ala Arg 
            180                 185                 190         


Arg Phe Ala Ala Phe Cys Ser Pro Asn Leu Leu Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Asn Met Glu His Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ala Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Glu 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg Arg Pro 
        355                 360                 365             


Ser Leu Gln Gly Asn Thr Leu Gly Gly Gly Val Ser Trp Leu Leu Ser 
    370                 375                 380                 


Leu Ser Gly Ser Gln Glu Ala Asp Ala Leu Arg Asn Ala Leu Val Pro 
385                 390                 395                 400 


Ser Leu Ala Cys Ala Ala Ala His Ala Gly Asp Val Glu Ala Leu Gln 
                405                 410                 415     


Ala Leu Val Glu Leu Gly Ser Asp Leu Gly Leu Val Asp Phe Asn Gly 
            420                 425                 430         


Gln Thr Pro Leu His Ala Ala Ala Arg Gly Gly His Thr Glu Ala Val 
        435                 440                 445             


Thr Met Leu Leu Gln Arg Gly Val Asp Val Asn Thr Arg Asp Thr Asp 
    450                 455                 460                 


Gly Phe Ser Pro Leu Leu Leu Ala Val Arg Gly Arg His Pro Gly Val 
465                 470                 475                 480 


Ile Gly Leu Leu Arg Glu Ala Gly Ala Ser Leu Ser Thr Gln Glu Leu 
                485                 490                 495     


Glu Glu Ala Gly Thr Glu Leu Cys Arg Leu Ala Tyr Arg Ala Asp Leu 
            500                 505                 510         


Glu Gly Leu Gln Val Trp Trp Gln Ala Gly Ala Asp Leu Gly Gln Pro 
        515                 520                 525             


Gly Tyr Asp Gly His Ser Ala Leu His Val Ala Glu Ala Ala Gly Asn 
    530                 535                 540                 


Leu Ala Val Val Ala Phe Leu Gln Ser Leu Glu Gly Ala Val Gly Ala 
545                 550                 555                 560 


Gln Ala Pro Cys Pro Glu Val Leu Pro Gly Val 
                565                 570     


<210>  42
<211>  571
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  42

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Glu 
        35                  40                  45              


Glu His Ala Arg Ala Arg Gly Leu Ser Glu Asp Thr Leu Val Leu Pro 
    50                  55                  60                  


Pro Ala Ser Arg Asn Gln Arg Ile Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile Arg Ile 
                85                  90                  95      


Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr His Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu Gln Lys Thr Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Ser Asn Gln Leu Phe Arg Gly Asn Arg Ala Thr Lys Val Asp Ala Arg 
            180                 185                 190         


Arg Phe Ala Ala Phe Cys Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Ile Thr Ile Asn Arg Glu Leu Val Arg Lys Val Asp Gly 
    210                 215                 220                 


Lys Ala Gly Leu Val Val His Ser Ser Met Glu Gln Asp Val Gly Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ala Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Met Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Thr Lys Pro Asp Leu Leu Gln Glu Leu Arg Val Ala Thr Glu 
        275                 280                 285             


Arg Gly Leu Val Ile Val Asn Cys Thr His Cys Leu Gln Gly Ala Val 
    290                 295                 300                 


Thr Thr Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg Arg Pro 
        355                 360                 365             


Ser Leu Gln Gly Asn Thr Leu Gly Gly Gly Val Ser Trp Leu Leu Ser 
    370                 375                 380                 


Leu Ser Gly Ser Gln Glu Ala Asp Ala Leu Arg Asn Ala Leu Val Pro 
385                 390                 395                 400 


Ser Leu Ala Cys Ala Ala Ala His Ala Gly Asp Val Glu Ala Leu Gln 
                405                 410                 415     


Ala Leu Val Glu Leu Gly Ser Asp Leu Gly Leu Val Asp Phe Asn Gly 
            420                 425                 430         


Gln Thr Pro Leu His Ala Ala Ala Arg Gly Gly His Thr Glu Ala Val 
        435                 440                 445             


Thr Met Leu Leu Gln Arg Gly Val Asp Val Asn Thr Arg Asp Thr Asp 
    450                 455                 460                 


Gly Phe Ser Pro Leu Leu Leu Ala Val Arg Gly Arg His Pro Gly Val 
465                 470                 475                 480 


Ile Gly Leu Leu Arg Glu Ala Gly Ala Ser Leu Ser Thr Gln Glu Leu 
                485                 490                 495     


Glu Glu Ala Gly Thr Glu Leu Cys Arg Leu Ala Tyr Arg Ala Asp Leu 
            500                 505                 510         


Glu Gly Leu Gln Val Trp Trp Gln Ala Gly Ala Asp Leu Gly Gln Pro 
        515                 520                 525             


Gly Tyr Asp Gly His Ser Ala Leu His Val Ala Glu Ala Ala Gly Asn 
    530                 535                 540                 


Leu Ala Val Val Ala Phe Leu Gln Ser Leu Glu Gly Ala Val Gly Ala 
545                 550                 555                 560 


Gln Ala Pro Cys Pro Glu Val Leu Pro Gly Val 
                565                 570     


<210>  43
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  43

Ser Glu Asp Thr Leu Val 
1               5       


<210>  44
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  44

Pro Asp His Ala Leu Ala 
1               5       


<210>  45
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  45

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Arg Ser Glu Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Glu 
        35                  40                  45              


Glu Phe Ala Arg Ala Arg Gly Leu Pro Asp His Ala Leu Ala Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile Arg Ile 
                85                  90                  95      


Ala Gln Ile Ile Lys Arg His Tyr Glu Gln Tyr Gln Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu Gln Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Cys Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Ser Met Glu His Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Glu 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Asp Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg Arg Pro 
        355                 360                 365             


Ser 
    


<210>  46
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  46

Met Ala Arg Ala Ser Gly Ser Glu Arg Arg Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Arg Ser Glu Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Glu 
        35                  40                  45              


Glu Phe Ala Arg Ala Arg Gly Leu Pro Asp His Ala Leu Ala Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Ala Glu Trp Ile Arg Ile 
                85                  90                  95      


Ala Gln Ile Ile Lys Arg His Tyr Glu Gln Tyr His Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu Gln Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Cys Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Ser Met Glu Gln Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ala Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Glu 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Asp Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg Arg Pro 
        355                 360                 365             


Ser 
    


<210>  47
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  47

Met Ala Arg Ala Ser Gly Ser Glu Arg Arg Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Arg Ser Glu Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Glu 
        35                  40                  45              


Glu Phe Ala Arg Ala Arg Gly Leu Pro Asp His Ala Leu Ala Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Ala Glu Trp Ile Arg Ile 
                85                  90                  95      


Ala Gln Ile Ile Lys Arg His Tyr Glu Gln Tyr His Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu Gln Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile His Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Arg Phe Glu Ala Phe Cys Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Glu Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Ser Met Glu Gln Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ala Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Glu 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Gln Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Asp Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg Arg Pro 
        355                 360                 365             


Ser 
    


<210>  48
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  48

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Arg Ser Glu Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Glu 
        35                  40                  45              


Glu Phe Ala Arg Ala Arg Gly Leu Ser Glu Asp Thr Leu Val Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile Arg Ile 
                85                  90                  95      


Ala Gln Ile Ile Lys Arg His Tyr Glu Gln Tyr Gln Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu Gln Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Cys Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Ser Met Glu His Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Glu 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Asp Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg Arg Pro 
        355                 360                 365             


Ser 
    


<210>  49
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  49

Met Ala Arg Ala Ser Gly Ser Glu Arg Arg Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Arg Ser Glu Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Glu 
        35                  40                  45              


Glu Phe Ala Arg Ala Arg Gly Leu Ser Glu Asp Thr Leu Val Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Ala Glu Trp Ile Arg Ile 
                85                  90                  95      


Ala Gln Ile Ile Lys Arg His Tyr Glu Gln Tyr His Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu Gln Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Cys Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Ser Met Glu Gln Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ala Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Glu 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Asp Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg Arg Pro 
        355                 360                 365             


Ser 
    


<210>  50
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  50

Met Ala Arg Ala Ser Gly Ser Glu Arg Arg Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Arg Ser Glu Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Glu 
        35                  40                  45              


Glu Phe Ala Arg Ala Arg Gly Leu Ser Glu Asp Thr Leu Val Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Ala Glu Trp Ile Arg Ile 
                85                  90                  95      


Ala Gln Ile Ile Lys Arg His Tyr Glu Gln Tyr His Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu Gln Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile His Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Arg Phe Glu Ala Phe Cys Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Glu Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Ser Met Glu Gln Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ala Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Glu 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Gln Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Asp Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg Arg Pro 
        355                 360                 365             


Ser 
    


<210>  51
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  51

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Lys 
        35                  40                  45              


Glu Phe Ala Gln Ala Gln Gly Leu Pro Asp His Ala Leu Ala Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile Arg Ile 
                85                  90                  95      


Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Ser Gly Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Ala Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Asn Met Glu His Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Gln 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Leu Pro Thr Ala Asp Leu His Gln Ser 
        355                 360                 365             


Ser 
    


<210>  52
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  52

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Lys 
        35                  40                  45              


Glu Phe Ala Gln Ala Gln Gly Leu Pro Asp His Ala Leu Ala Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile Arg Ile 
                85                  90                  95      


Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Ser Gly Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Ser Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Asn Met Glu His Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Gln 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Leu Pro Thr Ala Asp Leu His Gln Ser 
        355                 360                 365             


Ser 
    


<210>  53
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  53

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Lys 
        35                  40                  45              


Glu Phe Ala Gln Ala Gln Gly Leu Pro Asp His Ala Leu Ala Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile Arg Ile 
                85                  90                  95      


Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Ser Gly Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Val Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Asn Met Glu His Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Gln 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Leu Pro Thr Ala Asp Leu His Gln Ser 
        355                 360                 365             


Ser 
    


<210>  54
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  54

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Lys 
        35                  40                  45              


Glu Phe Ala Gln Ala Gln Gly Leu Pro Asp His Ala Leu Ala Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile Arg Ile 
                85                  90                  95      


Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Ser Gly Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Ala Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Cys Asp Pro Leu Val Val His Ser Asn Met Glu His Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Gln 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Leu Pro Thr Ala Asp Leu His Gln Ser 
        355                 360                 365             


Ser 
    


<210>  55
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  55

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Lys 
        35                  40                  45              


Glu Phe Ala Gln Ala Gln Gly Leu Pro Asp His Ala Leu Ala Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile Arg Ile 
                85                  90                  95      


Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Ser Gly Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Ala Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Cys Asp Pro Leu Val Val His Ser Asn Met Glu His Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Gln 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Cys Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Leu Pro Thr Ala Asp Leu His Gln Ser 
        355                 360                 365             


Ser 
    


<210>  56
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  56

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Lys 
        35                  40                  45              


Cys Phe Ala Gln Ala Gln Gly Leu Pro Asp His Ala Leu Ala Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile Arg Ile 
                85                  90                  95      


Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Ser Gly Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Ala Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Cys Asp Pro Leu Val Val His Ser Asn Met Glu His Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Gln 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Cys Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Leu Pro Thr Ala Asp Leu His Gln Ser 
        355                 360                 365             


Ser 
    


<210>  57
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  57

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Lys 
        35                  40                  45              


Cys Phe Ala Gln Ala Gln Gly Leu Pro Asp His Ala Leu Ala Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile Arg Ile 
                85                  90                  95      


Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Ser Gly Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Ala Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Cys Asp Pro Leu Val Val His Ser Asn Met Glu His Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Cys Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Gln 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Cys Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Leu Pro Thr Ala Asp Leu His Gln Ser 
        355                 360                 365             


Ser 
    


<210>  58
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  58

Met Ala Arg Ala Ser Gly Ser Glu Arg Arg Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Arg Ser Glu Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Glu 
        35                  40                  45              


Glu Phe Ala Arg Ala Arg Gly Leu Ser Glu Asp Thr Leu Val Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Ala Glu Trp Ile Arg Ile 
                85                  90                  95      


Ala Gln Ile Ile Lys Arg His Tyr Glu Gln Tyr His Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu Gln Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile His Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Arg Phe Glu Ala Phe Ala Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Glu Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Ser Met Glu Gln Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ala Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Glu 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Gln Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Asp Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg Arg Pro 
        355                 360                 365             


Ser 
    


<210>  59
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  59

Met Ala Arg Ala Ser Gly Ser Glu Arg Arg Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Arg Ser Glu Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Glu 
        35                  40                  45              


Glu Phe Ala Cys Ala Arg Gly Leu Ser Glu Asp Thr Leu Val Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Ala Glu Trp Ile Arg Ile 
                85                  90                  95      


Ala Gln Ile Ile Lys Arg His Tyr Glu Gln Tyr His Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu Gln Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile His Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Arg Phe Glu Ala Phe Ala Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Glu Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Ser Met Glu Gln Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ala Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Glu 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Gln Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Asp Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg Arg Pro 
        355                 360                 365             


Ser 
    


<210>  60
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  60

Met Ala Arg Ala Ser Gly Ser Glu Arg Arg Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Arg Ser Glu Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Glu 
        35                  40                  45              


Glu Phe Ala Cys Ala Arg Gly Leu Ser Glu Asp Thr Leu Val Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Ala Glu Trp Ile Arg Ile 
                85                  90                  95      


Ala Gln Ile Ile Lys Arg His Tyr Glu Gln Tyr His Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu Gln Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile His Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Arg Phe Glu Ala Phe Ala Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Glu Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Cys Asp Pro Leu Val Val His Ser Ser Met Glu Gln Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ala Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Glu 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Gln Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Asp Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg Arg Pro 
        355                 360                 365             


Ser 
    


<210>  61
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  61

Met Ala Arg Ala Ser Gly Ser Glu Arg Arg Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Arg Ser Glu Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Glu 
        35                  40                  45              


Glu Phe Ala Cys Ala Arg Gly Leu Ser Glu Asp Thr Leu Val Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Ala Glu Trp Ile Arg Ile 
                85                  90                  95      


Ala Gln Ile Ile Lys Arg His Tyr Glu Gln Tyr His Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu Gln Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile His Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Arg Phe Glu Ala Phe Ala Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Glu Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Cys Asp Pro Leu Val Val His Ser Ser Met Glu Gln Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ala Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Glu 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Gln Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Cys Leu Ser Leu Asp Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg Arg Pro 
        355                 360                 365             


Ser 
    


<210>  62
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  62

Met Ala Arg Ala Ser Gly Ser Glu Arg Arg Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Arg Ser Glu Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Glu 
        35                  40                  45              


Glu Phe Ala Cys Ala Arg Gly Leu Ser Glu Asp Thr Leu Val Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Ala Glu Trp Ile Arg Ile 
                85                  90                  95      


Ala Gln Ile Ile Lys Arg His Tyr Glu Gln Tyr His Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu Gln Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile His Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Arg Phe Glu Ala Phe Ala Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Glu Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Cys Asp Pro Leu Val Val His Ser Ser Met Glu Gln Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ala Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Cys Glu Leu Arg Ala Ala Ala Glu 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Gln Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Cys Leu Ser Leu Asp Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg Arg Pro 
        355                 360                 365             


Ser 
    


<210>  63
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  63

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Lys 
        35                  40                  45              


Glu Phe Ala Gln Ala Lys Gly Leu Pro Asp His Ala Leu Ala Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Lys Asp Trp Ile Arg Ile 
                85                  90                  95      


Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Ser Gly Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Cys Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Asp Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Asn Met Glu His Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Gln 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Lys Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Leu Pro Thr Ala Asp Leu His Gln Ser 
        355                 360                 365             


Ser 
    


<210>  64
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  64

Met Ala Arg Ala Ser Gly Ser Glu Arg Arg Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Arg Ser Glu Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Glu 
        35                  40                  45              


Glu Phe Ala Arg Ala Lys Gly Leu Pro Asp His Ala Leu Ala Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Lys Glu Trp Ile Arg Ile 
                85                  90                  95      


Ala Gln Ile Ile Lys Arg His Tyr Glu Gln Tyr His Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu Gln Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile His Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Arg Phe Glu Ala Phe Ala Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Glu Leu Val Arg Lys Val Asp Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Ser Met Glu Gln Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ala Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Glu 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Gln Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Lys Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Asp Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg Arg Pro 
        355                 360                 365             


Ser 
    


<210>  65
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  65

Met Ala Arg Ala Ser Gly Ser Glu Arg Arg Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Arg Ser Glu Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Glu 
        35                  40                  45              


Glu Phe Ala Arg Ala Lys Gly Leu Ser Glu Asp Thr Leu Val Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Lys Glu Trp Ile Arg Ile 
                85                  90                  95      


Ala Gln Ile Ile Lys Arg His Tyr Glu Gln Tyr His Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu Gln Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile His Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Arg Phe Glu Ala Phe Ala Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Glu Leu Val Arg Lys Val Asp Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Ser Met Glu Gln Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ala Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Glu 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Gln Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Lys Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Asp Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg Arg Pro 
        355                 360                 365             


Ser 
    


<210>  66
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  66

Met Ser Asp Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro 
1               5                   10                  15      


Glu Val Lys Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser 
            20                  25                  30          


Ser Glu Ile Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu 
        35                  40                  45              


Met Glu Ala Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Arg 
    50                  55                  60                  


Phe Leu Tyr Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu Asp 
65                  70                  75                  80  


Leu Asp Met Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile 
                85                  90                  95      


Gly Gly 
        


<210>  67
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  67

Met Ser Asp Gln Glu Ala Lys Pro Ser Thr Glu Asp Leu Gly Asp Lys 
1               5                   10                  15      


Lys Glu Gly Glu Tyr Ile Lys Leu Lys Val Ile Gly Gln Asp Ser Ser 
            20                  25                  30          


Glu Ile His Phe Lys Val Lys Met Thr Thr His Leu Lys Lys Leu Lys 
        35                  40                  45              


Glu Ser Tyr Cys Gln Arg Gln Gly Val Pro Met Asn Ser Leu Arg Phe 
    50                  55                  60                  


Leu Phe Glu Gly Gln Arg Ile Ala Asp Asn His Thr Pro Lys Glu Leu 
65                  70                  75                  80  


Gly Met Glu Glu Glu Asp Val Ile Glu Val Tyr Gln Glu Gln Thr Gly 
                85                  90                  95      


Gly 
    


<210>  68
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  68

Met Ala Asp Glu Lys Pro Lys Glu Gly Val Lys Thr Glu Asn Asn Asp 
1               5                   10                  15      


His Ile Asn Leu Lys Val Ala Gly Gln Asp Gly Ser Val Val Gln Phe 
            20                  25                  30          


Lys Ile Lys Arg His Thr Pro Leu Ser Lys Leu Met Lys Ala Tyr Cys 
        35                  40                  45              


Glu Arg Gln Gly Leu Ser Met Arg Gln Ile Arg Phe Arg Phe Asp Gly 
    50                  55                  60                  


Gln Pro Ile Asn Glu Thr Asp Thr Pro Ala Gln Leu Glu Met Glu Asp 
65                  70                  75                  80  


Glu Asp Thr Ile Asp Val Phe Gln Gln Gln Thr Gly Gly Val Tyr 
                85                  90                  95  


<210>  69
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  69

Met Ser Glu Glu Lys Pro Lys Glu Gly Val Lys Thr Glu Asn Asp His 
1               5                   10                  15      


Ile Asn Leu Lys Val Ala Gly Gln Asp Gly Ser Val Val Gln Phe Lys 
            20                  25                  30          


Ile Lys Arg His Thr Pro Leu Ser Lys Leu Met Lys Ala Tyr Cys Glu 
        35                  40                  45              


Arg Gln Gly Leu Ser Met Arg Gln Ile Arg Phe Arg Phe Asp Gly Gln 
    50                  55                  60                  


Pro Ile Asn Glu Thr Asp Thr Pro Ala Gln Leu Glu Met Glu Asp Glu 
65                  70                  75                  80  


Asp Thr Ile Asp Val Phe Gln Gln Gln Thr Gly Gly Val Pro Glu Ser 
                85                  90                  95      


Ser Leu Ala Gly His Ser Phe 
            100             


<210>  70
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  70

Met Ala Asn Glu Lys Pro Thr Glu Glu Val Lys Thr Glu Asn Asn Asn 
1               5                   10                  15      


His Ile Asn Leu Lys Val Ala Gly Gln Asp Gly Ser Val Val Gln Phe 
            20                  25                  30          


Lys Ile Lys Arg Gln Thr Pro Leu Ser Lys Leu Met Lys Ala Tyr Cys 
        35                  40                  45              


Glu Pro Arg Gly Leu Ser Met Lys Gln Ile Arg Phe Arg Phe Gly Gly 
    50                  55                  60                  


Gln Pro Ile Ser Gly Thr Asp Lys Pro Ala Gln Leu Glu Met Glu Asp 
65                  70                  75                  80  


Glu Asp Thr Ile Asp Val Phe Gln Gln Pro Thr Gly Gly Val Tyr 
                85                  90                  95  


<210>  71
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  71

Gln Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Glu Asp Asp Phe 
            20  


<210>  72
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  72

Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp 
        


<210>  73
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  73

Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15  


<210>  74
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  74

Met Ser Asp Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro 
1               5                   10                  15      


Glu Val Lys Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser 
            20                  25                  30          


Ser Glu Ile Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu 
        35                  40                  45              


Met Glu Ala Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Arg 
    50                  55                  60                  


Phe Leu Tyr Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu Asp 
65                  70                  75                  80  


Leu Asp Met Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile 
                85                  90                  95      


Gly Gly His Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu 
            100                 105                 110         


Ile Tyr Thr Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu 
        115                 120                 125             


Val Pro Gly Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe 
    130                 135                 140                 


His Asp Lys Glu Phe Ala Gln Ala Gln Gly Leu Pro Asp His Ala Leu 
145                 150                 155                 160 


Ala Leu Pro Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu 
                165                 170                 175     


Glu Lys Gln Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp 
            180                 185                 190         


Ile Arg Ile Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly 
        195                 200                 205             


Phe Val Val Ile His Gly Thr Asp Thr Met Ala Ser Gly Ala Ser Met 
    210                 215                 220                 


Leu Ser Phe Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly 
225                 230                 235                 240 


Ala Gln Val Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu 
                245                 250                 255     


Leu Gly Ala Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys 
            260                 265                 270         


Leu Phe Met Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val 
        275                 280                 285             


Asp Ser Gln Lys Phe Glu Ala Phe Ala Ser Pro Asn Leu Ser Pro Leu 
    290                 295                 300                 


Ala Thr Val Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys 
305                 310                 315                 320 


Val Lys Trp Lys Asp Pro Leu Val Val His Ser Asn Met Glu His Asp 
                325                 330                 335     


Val Ala Leu Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg 
            340                 345                 350         


Ala Phe Leu Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly 
        355                 360                 365             


Ser Gly Asn Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala 
    370                 375                 380                 


Ala Ala Gln Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg 
385                 390                 395                 400 


Gly Ser Val Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile 
                405                 410                 415     


Val Ser Gly Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser 
            420                 425                 430         


Tyr Val Leu Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu 
        435                 440                 445             


Leu Ala Lys Asp Leu Arg Gly Glu Met Thr Leu Pro Thr Ala Asp Leu 
    450                 455                 460                 


His Gln Ser Ser 
465             


<210>  75
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  75

Met Ser Asp Gln Glu Ala Lys Pro Ser Thr Glu Asp Leu Gly Asp Lys 
1               5                   10                  15      


Lys Glu Gly Glu Tyr Ile Lys Leu Lys Val Ile Gly Gln Asp Ser Ser 
            20                  25                  30          


Glu Ile His Phe Lys Val Lys Met Thr Thr His Leu Lys Lys Leu Lys 
        35                  40                  45              


Glu Ser Tyr Cys Gln Arg Gln Gly Val Pro Met Asn Ser Leu Arg Phe 
    50                  55                  60                  


Leu Phe Glu Gly Gln Arg Ile Ala Asp Asn His Thr Pro Lys Glu Leu 
65                  70                  75                  80  


Gly Met Glu Glu Glu Asp Val Ile Glu Val Tyr Gln Glu Gln Thr Gly 
                85                  90                  95      


Gly His Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile 
            100                 105                 110         


Tyr Thr Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val 
        115                 120                 125             


Pro Gly Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His 
    130                 135                 140                 


Asp Lys Glu Phe Ala Gln Ala Gln Gly Leu Pro Asp His Ala Leu Ala 
145                 150                 155                 160 


Leu Pro Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu 
                165                 170                 175     


Lys Gln Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile 
            180                 185                 190         


Arg Ile Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly Phe 
        195                 200                 205             


Val Val Ile His Gly Thr Asp Thr Met Ala Ser Gly Ala Ser Met Leu 
    210                 215                 220                 


Ser Phe Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala 
225                 230                 235                 240 


Gln Val Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu 
                245                 250                 255     


Gly Ala Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu 
            260                 265                 270         


Phe Met Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp 
        275                 280                 285             


Ser Gln Lys Phe Glu Ala Phe Ala Ser Pro Asn Leu Ser Pro Leu Ala 
    290                 295                 300                 


Thr Val Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val 
305                 310                 315                 320 


Lys Trp Lys Asp Pro Leu Val Val His Ser Asn Met Glu His Asp Val 
                325                 330                 335     


Ala Leu Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala 
            340                 345                 350         


Phe Leu Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser 
        355                 360                 365             


Gly Asn Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala 
    370                 375                 380                 


Ala Gln Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly 
385                 390                 395                 400 


Ser Val Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val 
                405                 410                 415     


Ser Gly Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr 
            420                 425                 430         


Val Leu Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu 
        435                 440                 445             


Ala Lys Asp Leu Arg Gly Glu Met Thr Leu Pro Thr Ala Asp Leu His 
    450                 455                 460                 


Gln Ser Ser 
465         


<210>  76
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  76

Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr 
            20                  25                  30          


Thr Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val Pro 
        35                  40                  45              


Gly Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp 
    50                  55                  60                  


Lys Glu Phe Ala Gln Ala Gln Gly Leu Pro Asp His Ala Leu Ala Leu 
65                  70                  75                  80  


Pro Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys 
                85                  90                  95      


Gln Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile Arg 
            100                 105                 110         


Ile Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly Phe Val 
        115                 120                 125             


Val Ile His Gly Thr Asp Thr Met Ala Ser Gly Ala Ser Met Leu Ser 
    130                 135                 140                 


Phe Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala Gln 
145                 150                 155                 160 


Val Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly 
                165                 170                 175     


Ala Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe 
            180                 185                 190         


Met Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser 
        195                 200                 205             


Gln Lys Phe Glu Ala Phe Ala Ser Pro Asn Leu Ser Pro Leu Ala Thr 
    210                 215                 220                 


Val Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys 
225                 230                 235                 240 


Trp Lys Asp Pro Leu Val Val His Ser Asn Met Glu His Asp Val Ala 
                245                 250                 255     


Leu Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala Phe 
            260                 265                 270         


Leu Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly 
        275                 280                 285             


Asn Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala 
    290                 295                 300                 


Gln Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser 
305                 310                 315                 320 


Val Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser 
                325                 330                 335     


Gly Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val 
            340                 345                 350         


Leu Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu Ala 
        355                 360                 365             


Lys Asp Leu Arg Gly Glu Met Thr Leu Pro Thr Ala Asp Leu His Gln 
    370                 375                 380                 


Ser Ser 
385     


<210>  77
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  77

Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Lys 
        35                  40                  45              


Glu Phe Ala Gln Ala Gln Gly Leu Pro Asp His Ala Leu Ala Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile Arg Ile 
                85                  90                  95      


Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Ser Gly Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Lys Phe Glu Ala Phe Ala Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Asn Met Glu His Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Gln 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Leu Pro Thr Ala Asp Leu His Gln Ser 
        355                 360                 365             


Ser Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
    370                 375                 380                 


Glu Asp Asp 
385         


<210>  78
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  78

Met Ser Asp Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro 
1               5                   10                  15      


Glu Val Lys Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser 
            20                  25                  30          


Ser Glu Ile Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu 
        35                  40                  45              


Met Glu Ala Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Arg 
    50                  55                  60                  


Phe Leu Tyr Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu Asp 
65                  70                  75                  80  


Leu Asp Met Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile 
                85                  90                  95      


Gly Gly His Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu 
            100                 105                 110         


Ile Tyr Thr Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu 
        115                 120                 125             


Val Pro Gly Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe 
    130                 135                 140                 


His Asp Lys Glu Phe Ala Gln Ala Gln Gly Leu Pro Asp His Ala Leu 
145                 150                 155                 160 


Ala Leu Pro Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu 
                165                 170                 175     


Glu Cys Gln Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp 
            180                 185                 190         


Ile Arg Ile Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly 
        195                 200                 205             


Phe Val Val Ile His Gly Thr Asp Thr Met Ala Ser Gly Ala Ser Met 
    210                 215                 220                 


Leu Ser Phe Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly 
225                 230                 235                 240 


Ala Gln Val Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu 
                245                 250                 255     


Leu Gly Ala Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys 
            260                 265                 270         


Leu Phe Met Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val 
        275                 280                 285             


Asp Ser Gln Lys Phe Glu Ala Phe Ala Ser Pro Asn Leu Ser Pro Leu 
    290                 295                 300                 


Ala Thr Val Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys 
305                 310                 315                 320 


Val Lys Trp Lys Asp Pro Leu Val Val His Ser Asn Met Glu His Asp 
                325                 330                 335     


Val Ala Leu Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg 
            340                 345                 350         


Ala Phe Leu Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly 
        355                 360                 365             


Ser Gly Asn Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala 
    370                 375                 380                 


Ala Ala Gln Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg 
385                 390                 395                 400 


Gly Ser Val Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile 
                405                 410                 415     


Val Ser Gly Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser 
            420                 425                 430         


Tyr Val Leu Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu 
        435                 440                 445             


Leu Ala Lys Asp Leu Arg Gly Glu Met Thr Leu Pro Thr Ala Asp Leu 
    450                 455                 460                 


His Gln Ser Ser Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly 
465                 470                 475                 480 


Cys Leu Trp Glu Asp Asp 
                485     


<210>  79
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  79

Met Ser Asp Gln Glu Ala Lys Pro Ser Thr Glu Asp Leu Gly Asp Lys 
1               5                   10                  15      


Lys Glu Gly Glu Tyr Ile Lys Leu Lys Val Ile Gly Gln Asp Ser Ser 
            20                  25                  30          


Glu Ile His Phe Lys Val Lys Met Thr Thr His Leu Lys Lys Leu Lys 
        35                  40                  45              


Glu Ser Tyr Cys Gln Arg Gln Gly Val Pro Met Asn Ser Leu Arg Phe 
    50                  55                  60                  


Leu Phe Glu Gly Gln Arg Ile Ala Asp Asn His Thr Pro Lys Glu Leu 
65                  70                  75                  80  


Gly Met Glu Glu Glu Asp Val Ile Glu Val Tyr Gln Glu Gln Thr Gly 
                85                  90                  95      


Gly His Met Ala Arg Ala Ser Gly Ser Glu Arg His Leu Leu Leu Ile 
            100                 105                 110         


Tyr Thr Gly Gly Thr Leu Gly Met Gln Ser Lys Gly Gly Val Leu Val 
        115                 120                 125             


Pro Gly Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His 
    130                 135                 140                 


Asp Lys Glu Phe Ala Gln Ala Gln Gly Leu Pro Asp His Ala Leu Ala 
145                 150                 155                 160 


Leu Pro Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu 
                165                 170                 175     


Cys Gln Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Asp Asp Trp Ile 
            180                 185                 190         


Arg Ile Ala Lys Ile Ile Glu Arg His Tyr Glu Gln Tyr Gln Gly Phe 
        195                 200                 205             


Val Val Ile His Gly Thr Asp Thr Met Ala Ser Gly Ala Ser Met Leu 
    210                 215                 220                 


Ser Phe Met Leu Glu Asn Leu His Lys Pro Val Ile Leu Thr Gly Ala 
225                 230                 235                 240 


Gln Val Pro Ile Arg Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu 
                245                 250                 255     


Gly Ala Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu 
            260                 265                 270         


Phe Met Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp 
        275                 280                 285             


Ser Gln Lys Phe Glu Ala Phe Ala Ser Pro Asn Leu Ser Pro Leu Ala 
    290                 295                 300                 


Thr Val Gly Ala Asp Val Thr Ile Ala Trp Asp Leu Val Arg Lys Val 
305                 310                 315                 320 


Lys Trp Lys Asp Pro Leu Val Val His Ser Asn Met Glu His Asp Val 
                325                 330                 335     


Ala Leu Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ser Leu Val Arg Ala 
            340                 345                 350         


Phe Leu Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser 
        355                 360                 365             


Gly Asn Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala 
    370                 375                 380                 


Ala Gln Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Arg Gly 
385                 390                 395                 400 


Ser Val Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val 
                405                 410                 415     


Ser Gly Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr 
            420                 425                 430         


Val Leu Gly Leu Pro Glu Leu Ser Leu Glu Arg Arg Gln Glu Leu Leu 
        435                 440                 445             


Ala Lys Asp Leu Arg Gly Glu Met Thr Leu Pro Thr Ala Asp Leu His 
    450                 455                 460                 


Gln Ser Ser Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys 
465                 470                 475                 480 


Leu Trp Glu Asp Asp 
                485 


<210>  80
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  80

Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg 
1               5                   10                  15      


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
            20                  25                  30          


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
        35                  40                  45              


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
    50                  55                  60                  


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
65                  70                  75                  80  


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
                85                  90                  95      


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
            100                 105                 110         


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
        115                 120                 125             


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
    130                 135                 140                 


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
145                 150                 155                 160 


Phe Gly Ala Phe Leu Val Gly 
                165         


<210>  81
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(16)
<223>  Residue may be present or absent

<400>  81

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


<210>  82
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (10)..(24)
<223>  Residue may be present or absent

<400>  82

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  


<210>  83
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  83

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  


<210>  84
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  84

Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Ser Gly Ser 
            


<210>  85
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  85

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


<210>  86
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  86

Met Ala Arg Ala Ser Gly Lys Glu Arg Arg Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Arg Ser Glu Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Glu 
        35                  40                  45              


Glu Phe Ala Arg Lys Lys Gly Leu Lys Lys Asp Thr Leu Val Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Ala Glu Trp Ile Arg Ile 
                85                  90                  95      


Ala Lys Ile Ile Lys Arg His Tyr Glu Lys Tyr His Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu Gln Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile His Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Arg Phe Glu Ala Phe Ala Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Glu Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Lys Met Glu Gln Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Lys Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Lys Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Lys Glu Leu Arg Ala Ala Ala Glu 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Gln Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Lys Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Lys Leu Ser Leu Asp Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg Arg Pro 
        355                 360                 365             


Ser 
    


<210>  87
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  87

Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg 
1               5                   10                  15      


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
            20                  25                  30          


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
        35                  40                  45              


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
    50                  55                  60                  


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
65                  70                  75                  80  


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
                85                  90                  95      


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
            100                 105                 110         


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
        115                 120                 125             


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
    130                 135                 140                 


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
145                 150                 155                 160 


Phe Gly Ala Phe Leu Val Gly Gly Arg Glu Arg Gly Pro Gln Arg Val 
                165                 170                 175     


Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser 
            180                 185                 190         


Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp 
        195                 200                 205             


Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg 
    210                 215                 220                 


Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser 
225                 230                 235                 240 


Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn 
                245                 250                 255     


Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp 
            260                 265                 270         


Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp 
        275                 280                 285             


Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu 
    290                 295                 300                 


Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile 
305                 310                 315                 320 


Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Ser 
                325                 330                 335     


Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg 
            340                 345                 350         


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
        355                 360                 365             


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
    370                 375                 380                 


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
385                 390                 395                 400 


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
                405                 410                 415     


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
            420                 425                 430         


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
        435                 440                 445             


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
    450                 455                 460                 


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
465                 470                 475                 480 


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
                485                 490                 495     


Phe Gly Ala Phe Leu Val Gly 
            500             


<210>  88
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  88

Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg 
1               5                   10                  15      


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
            20                  25                  30          


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
        35                  40                  45              


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
    50                  55                  60                  


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
65                  70                  75                  80  


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
                85                  90                  95      


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
            100                 105                 110         


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
        115                 120                 125             


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
    130                 135                 140                 


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
145                 150                 155                 160 


Phe Gly Ala Phe Leu Val Gly Ser Arg Glu Arg Gly Pro Gln Arg Val 
                165                 170                 175     


Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser 
            180                 185                 190         


Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp 
        195                 200                 205             


Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg 
    210                 215                 220                 


Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser 
225                 230                 235                 240 


Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn 
                245                 250                 255     


Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp 
            260                 265                 270         


Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp 
        275                 280                 285             


Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu 
    290                 295                 300                 


Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile 
305                 310                 315                 320 


Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Ser 
                325                 330                 335     


Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg 
            340                 345                 350         


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
        355                 360                 365             


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
    370                 375                 380                 


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
385                 390                 395                 400 


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
                405                 410                 415     


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
            420                 425                 430         


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
        435                 440                 445             


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
    450                 455                 460                 


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
465                 470                 475                 480 


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
                485                 490                 495     


Phe Gly Ala Phe Leu Val Gly 
            500             


<210>  89
<211>  874
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  89

Met Ala Arg Ala Ser Gly Ser Glu Arg Arg Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Arg Ser Glu Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Glu 
        35                  40                  45              


Glu Phe Ala Arg Ala Arg Gly Leu Ser Glu Asp Thr Leu Val Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Ala Glu Trp Ile Arg Ile 
                85                  90                  95      


Ala Gln Ile Ile Lys Arg His Tyr Glu Gln Tyr His Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu Gln Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile His Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Arg Phe Glu Ala Phe Ala Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Glu Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Ser Met Glu Gln Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ala Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Glu 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Gln Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Leu Ser Leu Asp Arg Arg Gln Glu Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg Arg Pro 
        355                 360                 365             


Ser Thr Ser Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr 
    370                 375                 380                 


Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn 
385                 390                 395                 400 


Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser 
                405                 410                 415     


Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val 
            420                 425                 430         


Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg 
        435                 440                 445             


Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val 
    450                 455                 460                 


Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met 
465                 470                 475                 480 


Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu 
                485                 490                 495     


Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg 
            500                 505                 510         


Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu 
        515                 520                 525             


Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Arg Glu Arg Gly Pro 
    530                 535                 540                 


Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 
545                 550                 555                 560 


Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 
                565                 570                 575     


Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 
            580                 585                 590         


His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 
        595                 600                 605             


Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 
    610                 615                 620                 


Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 
625                 630                 635                 640 


Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 
                645                 650                 655     


Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 
            660                 665                 670         


Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 
        675                 680                 685             


His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu 
    690                 695                 700                 


Val Gly Ser Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr 
705                 710                 715                 720 


Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn 
                725                 730                 735     


Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser 
            740                 745                 750         


Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val 
        755                 760                 765             


Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg 
    770                 775                 780                 


Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val 
785                 790                 795                 800 


Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met 
                805                 810                 815     


Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu 
            820                 825                 830         


Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg 
        835                 840                 845             


Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu 
    850                 855                 860                 


Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
865                 870                 


<210>  90
<211>  883
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  90

Ser Glu Arg Arg Leu Leu Leu Ile Tyr Thr Gly Gly Thr Leu Gly Met 
1               5                   10                  15      


Arg Ser Glu Gly Gly Val Leu Val Pro Gly Pro Gly Leu Val Thr Leu 
            20                  25                  30          


Leu Arg Thr Leu Pro Met Phe His Asp Glu Glu Phe Ala Arg Ala Arg 
        35                  40                  45              


Gly Leu Ser Glu Asp Thr Leu Val Leu Pro Pro Ala Ser His Gly Pro 
    50                  55                  60                  


Arg Val Leu Tyr Thr Val Leu Glu Cys Gln Pro Leu Leu Asp Ser Ser 
65                  70                  75                  80  


Asp Met Thr Ile Ala Glu Trp Ile Arg Ile Ala Gln Ile Ile Lys Arg 
                85                  90                  95      


His Tyr Glu Gln Tyr His Gly Phe Val Val Ile His Gly Thr Asp Thr 
            100                 105                 110         


Met Ala Phe Ala Ala Ser Met Leu Ser Phe Met Leu Glu Asn Leu Gln 
        115                 120                 125             


Lys Pro Val Ile Leu Thr Gly Ala Gln Val Pro Ile His Val Leu Trp 
    130                 135                 140                 


Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala Leu Leu Val Ala Gly Gln 
145                 150                 155                 160 


Tyr Ile Ile Pro Glu Val Cys Leu Phe Met Asn Ser Gln Leu Phe Arg 
                165                 170                 175     


Gly Asn Arg Val Thr Lys Val Asp Ser Gln Arg Phe Glu Ala Phe Ala 
            180                 185                 190         


Ser Pro Asn Leu Ser Pro Leu Ala Thr Val Gly Ala Asp Val Thr Ile 
        195                 200                 205             


Ala Trp Glu Leu Val Arg Lys Val Lys Trp Lys Asp Pro Leu Val Val 
    210                 215                 220                 


His Ser Ser Met Glu Gln Asp Val Ala Leu Leu Arg Leu Tyr Pro Gly 
225                 230                 235                 240 


Ile Pro Ala Ala Leu Val Arg Ala Phe Leu Gln Pro Pro Leu Lys Gly 
                245                 250                 255     


Val Val Leu Glu Thr Phe Gly Ser Gly Asn Gly Pro Ser Lys Pro Asp 
            260                 265                 270         


Leu Leu Gln Glu Leu Arg Ala Ala Ala Glu Arg Gly Leu Ile Met Val 
        275                 280                 285             


Asn Cys Ser Gln Cys Leu Gln Gly Ser Val Thr Pro Gly Tyr Ala Thr 
    290                 295                 300                 


Ser Leu Ala Gly Ala Asn Ile Val Ser Gly Leu Asp Met Thr Ser Glu 
305                 310                 315                 320 


Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu Gly Leu Pro Glu Leu Ser 
                325                 330                 335     


Leu Asp Arg Arg Gln Glu Leu Leu Ala Lys Asp Leu Arg Gly Glu Met 
            340                 345                 350         


Thr Pro Pro Ser Val Glu Glu Arg Arg Pro Ser Leu Gln Gly Asn Thr 
        355                 360                 365             


Leu Gly Gly Gly Val Ser Trp Leu Leu Ser Thr Ser Arg Glu Arg Gly 
    370                 375                 380                 


Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
385                 390                 395                 400 


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
                405                 410                 415     


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
            420                 425                 430         


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
        435                 440                 445             


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
    450                 455                 460                 


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
465                 470                 475                 480 


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
                485                 490                 495     


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
            500                 505                 510         


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
        515                 520                 525             


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
    530                 535                 540                 


Leu Val Gly Ser Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile 
545                 550                 555                 560 


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
                565                 570                 575     


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
            580                 585                 590         


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
        595                 600                 605             


Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
    610                 615                 620                 


Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
625                 630                 635                 640 


Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
                645                 650                 655     


Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
            660                 665                 670         


Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
        675                 680                 685             


Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
    690                 695                 700                 


Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Ser Arg Glu Arg Gly 
705                 710                 715                 720 


Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
                725                 730                 735     


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
            740                 745                 750         


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
        755                 760                 765             


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
    770                 775                 780                 


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
785                 790                 795                 800 


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
                805                 810                 815     


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
            820                 825                 830         


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
        835                 840                 845             


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
    850                 855                 860                 


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
865                 870                 875                 880 


Leu Val Gly 
            


<210>  91
<211>  872
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  91

Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg 
1               5                   10                  15      


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
            20                  25                  30          


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
        35                  40                  45              


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
    50                  55                  60                  


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
65                  70                  75                  80  


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
                85                  90                  95      


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
            100                 105                 110         


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
        115                 120                 125             


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
    130                 135                 140                 


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
145                 150                 155                 160 


Phe Gly Ala Phe Leu Val Gly Ser Arg Glu Arg Gly Pro Gln Arg Val 
                165                 170                 175     


Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser 
            180                 185                 190         


Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp 
        195                 200                 205             


Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg 
    210                 215                 220                 


Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser 
225                 230                 235                 240 


Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn 
                245                 250                 255     


Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp 
            260                 265                 270         


Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp 
        275                 280                 285             


Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu 
    290                 295                 300                 


Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile 
305                 310                 315                 320 


Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Ser 
                325                 330                 335     


Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg 
            340                 345                 350         


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
        355                 360                 365             


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
    370                 375                 380                 


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
385                 390                 395                 400 


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
                405                 410                 415     


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
            420                 425                 430         


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
        435                 440                 445             


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
    450                 455                 460                 


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
465                 470                 475                 480 


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
                485                 490                 495     


Phe Gly Ala Phe Leu Val Gly Met Ala Arg Ala Ser Gly Ser Glu Arg 
            500                 505                 510         


Arg Leu Leu Leu Ile Tyr Thr Gly Gly Thr Leu Gly Met Arg Ser Glu 
        515                 520                 525             


Gly Gly Val Leu Val Pro Gly Pro Gly Leu Val Thr Leu Leu Arg Thr 
    530                 535                 540                 


Leu Pro Met Phe His Asp Glu Glu Phe Ala Arg Ala Arg Gly Leu Ser 
545                 550                 555                 560 


Glu Asp Thr Leu Val Leu Pro Pro Ala Ser His Gly Pro Arg Val Leu 
                565                 570                 575     


Tyr Thr Val Leu Glu Cys Gln Pro Leu Leu Asp Ser Ser Asp Met Thr 
            580                 585                 590         


Ile Ala Glu Trp Ile Arg Ile Ala Gln Ile Ile Lys Arg His Tyr Glu 
        595                 600                 605             


Gln Tyr His Gly Phe Val Val Ile His Gly Thr Asp Thr Met Ala Phe 
    610                 615                 620                 


Ala Ala Ser Met Leu Ser Phe Met Leu Glu Asn Leu Gln Lys Pro Val 
625                 630                 635                 640 


Ile Leu Thr Gly Ala Gln Val Pro Ile His Val Leu Trp Asn Asp Ala 
                645                 650                 655     


Arg Glu Asn Leu Leu Gly Ala Leu Leu Val Ala Gly Gln Tyr Ile Ile 
            660                 665                 670         


Pro Glu Val Cys Leu Phe Met Asn Ser Gln Leu Phe Arg Gly Asn Arg 
        675                 680                 685             


Val Thr Lys Val Asp Ser Gln Arg Phe Glu Ala Phe Ala Ser Pro Asn 
    690                 695                 700                 


Leu Ser Pro Leu Ala Thr Val Gly Ala Asp Val Thr Ile Ala Trp Glu 
705                 710                 715                 720 


Leu Val Arg Lys Val Lys Trp Lys Asp Pro Leu Val Val His Ser Ser 
                725                 730                 735     


Met Glu Gln Asp Val Ala Leu Leu Arg Leu Tyr Pro Gly Ile Pro Ala 
            740                 745                 750         


Ala Leu Val Arg Ala Phe Leu Gln Pro Pro Leu Lys Gly Val Val Leu 
        755                 760                 765             


Glu Thr Phe Gly Ser Gly Asn Gly Pro Ser Lys Pro Asp Leu Leu Gln 
    770                 775                 780                 


Glu Leu Arg Ala Ala Ala Glu Arg Gly Leu Ile Met Val Asn Cys Ser 
785                 790                 795                 800 


Gln Cys Leu Gln Gly Ser Val Thr Pro Gly Tyr Ala Thr Ser Leu Ala 
                805                 810                 815     


Gly Ala Asn Ile Val Ser Gly Leu Asp Met Thr Ser Glu Ala Ala Leu 
            820                 825                 830         


Ala Lys Leu Ser Tyr Val Leu Gly Leu Pro Glu Leu Ser Leu Asp Arg 
        835                 840                 845             


Arg Gln Glu Leu Leu Ala Lys Asp Leu Arg Gly Glu Met Thr Pro Pro 
    850                 855                 860                 


Ser Val Glu Glu Arg Arg Pro Ser 
865                 870         


<210>  92
<211>  891
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  92

Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg 
1               5                   10                  15      


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
            20                  25                  30          


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
        35                  40                  45              


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
    50                  55                  60                  


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
65                  70                  75                  80  


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
                85                  90                  95      


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
            100                 105                 110         


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
        115                 120                 125             


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
    130                 135                 140                 


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
145                 150                 155                 160 


Phe Gly Ala Phe Leu Val Gly Ser Arg Glu Arg Gly Pro Gln Arg Val 
                165                 170                 175     


Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser 
            180                 185                 190         


Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp 
        195                 200                 205             


Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg 
    210                 215                 220                 


Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser 
225                 230                 235                 240 


Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn 
                245                 250                 255     


Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp 
            260                 265                 270         


Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp 
        275                 280                 285             


Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu 
    290                 295                 300                 


Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile 
305                 310                 315                 320 


Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Ser 
                325                 330                 335     


Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg 
            340                 345                 350         


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
        355                 360                 365             


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
    370                 375                 380                 


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
385                 390                 395                 400 


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
                405                 410                 415     


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
            420                 425                 430         


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
        435                 440                 445             


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
    450                 455                 460                 


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
465                 470                 475                 480 


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
                485                 490                 495     


Phe Gly Ala Phe Leu Val Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
            500                 505                 510         


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Met Ala Arg Ala Ser Gly 
        515                 520                 525             


Ser Glu Arg Arg Leu Leu Leu Ile Tyr Thr Gly Gly Thr Leu Gly Met 
    530                 535                 540                 


Arg Ser Glu Gly Gly Val Leu Val Pro Gly Pro Gly Leu Val Thr Leu 
545                 550                 555                 560 


Leu Arg Thr Leu Pro Met Phe His Asp Glu Glu Phe Ala Arg Ala Arg 
                565                 570                 575     


Gly Leu Ser Glu Asp Thr Leu Val Leu Pro Pro Ala Ser His Gly Pro 
            580                 585                 590         


Arg Val Leu Tyr Thr Val Leu Glu Cys Gln Pro Leu Leu Asp Ser Ser 
        595                 600                 605             


Asp Met Thr Ile Ala Glu Trp Ile Arg Ile Ala Gln Ile Ile Lys Arg 
    610                 615                 620                 


His Tyr Glu Gln Tyr His Gly Phe Val Val Ile His Gly Thr Asp Thr 
625                 630                 635                 640 


Met Ala Phe Ala Ala Ser Met Leu Ser Phe Met Leu Glu Asn Leu Gln 
                645                 650                 655     


Lys Pro Val Ile Leu Thr Gly Ala Gln Val Pro Ile His Val Leu Trp 
            660                 665                 670         


Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala Leu Leu Val Ala Gly Gln 
        675                 680                 685             


Tyr Ile Ile Pro Glu Val Cys Leu Phe Met Asn Ser Gln Leu Phe Arg 
    690                 695                 700                 


Gly Asn Arg Val Thr Lys Val Asp Ser Gln Arg Phe Glu Ala Phe Ala 
705                 710                 715                 720 


Ser Pro Asn Leu Ser Pro Leu Ala Thr Val Gly Ala Asp Val Thr Ile 
                725                 730                 735     


Ala Trp Glu Leu Val Arg Lys Val Lys Trp Lys Asp Pro Leu Val Val 
            740                 745                 750         


His Ser Ser Met Glu Gln Asp Val Ala Leu Leu Arg Leu Tyr Pro Gly 
        755                 760                 765             


Ile Pro Ala Ala Leu Val Arg Ala Phe Leu Gln Pro Pro Leu Lys Gly 
    770                 775                 780                 


Val Val Leu Glu Thr Phe Gly Ser Gly Asn Gly Pro Ser Lys Pro Asp 
785                 790                 795                 800 


Leu Leu Gln Glu Leu Arg Ala Ala Ala Glu Arg Gly Leu Ile Met Val 
                805                 810                 815     


Asn Cys Ser Gln Cys Leu Gln Gly Ser Val Thr Pro Gly Tyr Ala Thr 
            820                 825                 830         


Ser Leu Ala Gly Ala Asn Ile Val Ser Gly Leu Asp Met Thr Ser Glu 
        835                 840                 845             


Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu Gly Leu Pro Glu Leu Ser 
    850                 855                 860                 


Leu Asp Arg Arg Gln Glu Leu Leu Ala Lys Asp Leu Arg Gly Glu Met 
865                 870                 875                 880 


Thr Pro Pro Ser Val Glu Glu Arg Arg Pro Ser 
                885                 890     


<210>  93
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  93

Met Ala Arg Ala Ser Gly Ser Glu Arg Arg Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Arg Ser Glu Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Glu 
        35                  40                  45              


Glu Phe Ala Arg Ala Arg Gly Leu Ser Glu Asp Thr Leu Val Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Ala Glu Trp Ile Arg Ile 
                85                  90                  95      


Ala Gln Ile Ile Lys Arg His Tyr Glu Gln Tyr His Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu Gln Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile His Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Arg Phe Glu Ala Phe Ala Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Glu Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
225                 230                 235                 240 


Glu Asp Asp Asp Pro Leu Val Val His Ser Ser Met Glu Gln Asp Val 
                245                 250                 255     


Ala Leu Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ala Leu Val Arg Ala 
            260                 265                 270         


Phe Leu Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser 
        275                 280                 285             


Gly Asn Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala 
    290                 295                 300                 


Ala Glu Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Gln Gly 
305                 310                 315                 320 


Ser Val Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val 
                325                 330                 335     


Ser Gly Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr 
            340                 345                 350         


Val Leu Gly Leu Pro Glu Leu Ser Leu Asp Arg Arg Gln Glu Leu Leu 
        355                 360                 365             


Ala Lys Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg 
    370                 375                 380                 


Arg Pro Ser 
385         


<210>  94
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  94

Met Ala Arg Ala Ser Gly Ser Glu Arg Arg Leu Leu Leu Ile Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Leu Gly Met Arg Ser Glu Gly Gly Val Leu Val Pro Gly 
            20                  25                  30          


Pro Gly Leu Val Thr Leu Leu Arg Thr Leu Pro Met Phe His Asp Glu 
        35                  40                  45              


Glu Phe Ala Arg Ala Arg Gly Leu Ser Glu Asp Thr Leu Val Leu Pro 
    50                  55                  60                  


Pro Ala Ser His Gly Pro Arg Val Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Leu Asp Ser Ser Asp Met Thr Ile Ala Glu Trp Ile Arg Ile 
                85                  90                  95      


Ala Gln Ile Ile Lys Arg His Tyr Glu Gln Tyr His Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu Gln Lys Pro Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile His Val Leu Trp Asn Asp Ala Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Gln Tyr Ile Ile Pro Glu Val Cys Leu Phe Met 
                165                 170                 175     


Asn Ser Gln Leu Phe Arg Gly Asn Arg Val Thr Lys Val Asp Ser Gln 
            180                 185                 190         


Arg Phe Glu Ala Phe Ala Ser Pro Asn Leu Ser Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Val Thr Ile Ala Trp Glu Leu Val Arg Lys Val Lys Trp 
    210                 215                 220                 


Lys Asp Pro Leu Val Val His Ser Ser Met Glu Gln Asp Val Ala Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ala Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Leu Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Ser Lys Pro Asp Leu Leu Gln Glu Leu Arg Ala Ala Ala Glu 
        275                 280                 285             


Arg Gly Leu Ile Met Val Asn Cys Ser Gln Cys Leu Gln Gly Ser Val 
    290                 295                 300                 


Thr Pro Gly Tyr Ala Thr Ser Leu Ala Gly Ala Asn Ile Val Ser Gly 
305                 310                 315                 320 


Leu Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr Val Leu 
                325                 330                 335     


Gly Leu Pro Glu Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly 
            340                 345                 350         


Cys Leu Trp Glu Asp Asp Leu Ser Leu Asp Arg Arg Gln Glu Leu Leu 
        355                 360                 365             


Ala Lys Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg 
    370                 375                 380                 


Arg Pro Ser 
385         


