                         SEQUENCE LISTING

<110>  La Jolla Institute
       Newmeyer, Don
        Liu, Tong
      
 
<120>  AN ANTI-APOPTOTIC FUNCTION OF PKM2 AND INTRACELLULARLY EXPRESSED SCFV ANTIBODIES

<130>  2017-02-02

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  269
<212>  PRT
<213>  artificial

<220>
<223>  Artificial intrabody clone 12

<400>  1

Met Ala Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Thr Tyr Trp Met His Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Leu 
        35                  40                  45              


Trp Val Ser Arg Ile Asn Pro Asp Gly Ser Ala Thr Ile Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly His Pro Leu Ser Gly Tyr Pro Gly Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Val Ala Asp Pro Arg Leu Cys Ser Leu 
    130                 135                 140                 


Ser Arg Leu Pro Ser Leu His Leu Leu Glu His Gln Gln Ser His Leu 
145                 150                 155                 160 


His Phe Thr Ser Gly Ile Asn Val Gly Ala Tyr Arg Ile Tyr Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Ser Pro Pro Gln Phe Leu Leu Arg Tyr Lys Ser 
            180                 185                 190         


Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro Ser Arg Phe Ser Gly 
        195                 200                 205             


Ser Arg Asp Ala Ser Ala Asn Ala Gly Ile Leu Leu Ile Ser Gly Leu 
    210                 215                 220                 


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ile Trp His Ser Ser 
225                 230                 235                 240 


Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Trp Gly Ser 
                245                 250                 255     


Gly Leu Ala Ser Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            260                 265                 


<210>  2
<211>  265
<212>  PRT
<213>  artificial

<220>
<223>  artificial intrabody clone 5

<400>  2

Met Ala Gln Val Gln Leu Val Glu Thr Gly Pro Gly Leu Val Lys Pro 
1               5                   10                  15      


Ser Glu Thr Leu Ser Leu Arg Cys Thr Val Ser Gly Gly Ser Phe Asp 
            20                  25                  30          


Asn Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Tyr Ile Gly Tyr Val Phe Pro Ser Thr Gly Ala Thr Asn Tyr Asn Pro 
    50                  55                  60                  


Ser Leu Gly Ser Arg Val Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln 
65                  70                  75                  80  


Phe Ser Leu Thr Leu Thr Ser Val Thr Thr Ala Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Val Arg Ser Gly His Asp Leu Trp Thr Gly Ser Thr Trp Phe 
            100                 105                 110         


Asp Pro Trp Gly Gln Trp Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu 
    130                 135                 140                 


Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
145                 150                 155                 160 


Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala 
            180                 185                 190         


Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Ile 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Arg Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Leu Gly Gly Leu Ala Ser 
                245                 250                 255     


Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            260                 265 


<210>  3
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  CDR1 (H) for IB5

<400>  3

Gly Ser Phe Asp Asn Tyr Tyr Trp 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  CDR2(H)  for IB5

<400>  4

Phe Pro Ser Thr Gly Ala Thr Asn 
1               5               


<210>  5
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  CDR3(H) for IB5

<400>  5

His Asp Leu Trp Thr Gly Ser Thr Trp Phe 
1               5                   10  


<210>  6
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  CDR1(L) for IB5

<400>  6

Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10  


<210>  7
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  CDR2(L) for IB5

<400>  7

Ala Ser Ser Arg Ala Thr 
1               5       


<210>  8
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  CDR3(L) for IB5

<400>  8

Gln Arg Ser Asn Trp Pro Arg Thr 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  CDR1(H) for IB12

<400>  9

Phe Thr Phe Ser Thr Tyr Trp Met 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  CDR2(H) for IB12

<400>  10

Asn Pro Asp Gly Ser Ala Thr Ile 
1               5               


<210>  11
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  CDR3(H) for IB12

<400>  11

His Pro Leu Ser Gly Tyr Pro Gly Tyr Phe 
1               5                   10  


<210>  12
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  CDR1(L) for IB12

<400>  12

Gly Ile Asn Val Gly Ala Tyr Arg Ile Tyr 
1               5                   10  


<210>  13
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  CDR2(L) for IB12

<400>  13

Ser Asp Ser Asp Lys Gln 
1               5       


<210>  14
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  CDR3(L) for IB12

<400>  14

Ile Trp His Ser Ser Ala Trp Val 
1               5               


<210>  15
<211>  55
<212>  PRT
<213>  homo sapiens

<400>  15

Ile Ala Arg Glu Ala Glu Ala Ala Ile Tyr His Leu Gln Leu Phe Glu 
1               5                   10                  15      


Glu Leu Arg Arg Leu Ala Pro Ile Thr Ser Asp Pro Thr Glu Ala Thr 
            20                  25                  30          


Ala Val Gly Ala Val Glu Ala Ser Phe Lys Cys Cys Ser Gly Ala Ile 
        35                  40                  45              


Ile Val Leu Thr Lys Ser Gly 
    50                  55  


<210>  16
<211>  55
<212>  PRT
<213>  homo sapiens

<400>  16

Ile Ala Arg Glu Ala Glu Ala Ala Met Phe His Arg Lys Leu Phe Glu 
1               5                   10                  15      


Glu Leu Val Arg Ala Ser Ser His Ser Thr Asp Leu Met Glu Ala Met 
            20                  25                  30          


Ala Met Gly Ser Val Glu Ala Ser Tyr Lys Cys Leu Ala Ala Ala Leu 
        35                  40                  45              


Ile Val Leu Thr Glu Ser Gly 
    50                  55  


