                         SEQUENCE LISTING

<110>  BIOVERATIV THERAPEUTICS INC.
       Seregin, Alexey
       Liu, Tongyao
       Patarroyo-White, Susannah
       Drager, Douglas
       Peters, Robert T.
       Liu, Jiayun

 
<120>  Nucleic Acid Molecules and Uses Thereof

<130>  4159.493PC01/C-K/BMD

<150>  US 62/543,297
<151>  2017-08-09

<160>  184   

<170>  PatentIn version 3.5

<210>  1
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-5

<400>  1
atgcaaatcg aactgagcac ctgtttcttc ctctgcctgc tgagattctg tttctccgcg       60

acccgccgat actacctggg agcagtggag ctctcctggg attacatgca gagcgacctt      120

ggggagctgc ccgtggatgc caggttccct ccccgggtgc caaagtcgtt tccgttcaac      180

acctccgtgg tgtacaagaa aactctgttc gtggagttca ccgaccacct gttcaatatc      240

gccaagccca gacctccctg gatggggctg ttgggaccta ccatccaagc ggaggtgtac      300

gacactgtgg tcatcactct gaagaacatg gcctcgcatc ccgtgtccct gcacgccgtg      360

ggagtgtctt actggaaagc gtccgagggg gccgaatacg acgaccagac ctcgcagaga      420

gaaaaggaag atgacaaggt gttcccagga ggatcgcaca cctacgtgtg gcaagtgttg      480

aaggagaacg gcccaatggc ctccgacccg ctgtgcctga cctactcgta cctgtcccac      540

gtggacctcg tgaaggacct caactcggga ctgattggag ccctgctggt ctgcagggaa      600

ggctcactgg cgaaagaaaa gactcagacc ttgcacaagt tcattctgct gttcgctgtg      660

ttcgacgagg ggaagtcgtg gcacagcgag actaagaact ccctgatgca agatagagat      720

gccgcctccg cccgggcctg gcctaagatg cacaccgtga acggttacgt gaaccgctcc      780

ctccctggcc tgattggatg ccaccggaag tccgtgtact ggcacgtgat cgggatgggg      840

accacccccg aggtgcacag catcttcctg gaaggtcaca catttctcgt gcgcaaccac      900

cggcaggcct ccctggaaat cagccccatt accttcctca ctgcccagac tctgctgatg      960

gacctgggac agttcctgct gttctgccat atctcctccc accaacatga cggaatggag     1020

gcatacgtga aggtcgattc ctgccctgag gaaccccagc tccgcatgaa gaacaatgag     1080

gaagccgagg actacgacga cgacctgacg gatagcgaga tggatgtggt ccggttcgat     1140

gacgataaca gcccttcctt catccaaatt cgctcggtgg caaagaagca ccccaagacc     1200

tgggtgcatt acattgcggc ggaagaagag gactgggatt atgccccgct tgtcctcgct     1260

cctgacgacc ggagctacaa gagccagtac ctgaacaacg gtccacagag gatcggtaga     1320

aagtacaaga aggtccgctt catggcctat accgacgaaa ccttcaaaac tagagaggcc     1380

atccaacacg aatccggcat cctgggcccg ctcttgtacg gagaagtcgg cgacaccctt     1440

ctcattatct tcaagaacca ggcttcccgg ccgtacaaca tctatccgca tgggatcact     1500

gacgtgcgcc cactgtactc gcggcgcctg cccaagggtg tcaaacacct gaaggatttt     1560

ccgatccttc cgggagaaat cttcaagtac aagtggaccg tgaccgtgga agatggccca     1620

actaagtctg accctagatg cctcacccgc tactactcat ccttcgtcaa catggagcgc     1680

gacctggcca gcggactgat cggcccgctg ctgatttgct acaaggaatc agtggaccaa     1740

cggggaaacc agatcatgtc ggataagagg aacgtcatcc tcttctccgt gtttgacgaa     1800

aaccggtcgt ggtacctgac tgaaaacatc cagcggttcc tccccaaccc cgcgggcgtg     1860

cagctggaag atcctgagtt tcaggcatca aacatcatgc actccattaa cggctacgtg     1920

ttcgattcgc tgcagctgag cgtgtgtctg cacgaagtgg cctactggta catcctgtcc     1980

attggtgccc agactgactt cctgtccgtg tttttctccg gctacacgtt caagcacaag     2040

atggtgtacg aggacaccct gaccctcttc cctttttccg gcgaaactgt gtttatgagc     2100

atggagaatc ccggcctgtg gatcttgggc tgccacaaca gcgacttccg taacagagga     2160

atgactgcgc tgctcaaggt gtccagctgc gacaagaaca ccggagacta ttatgaggac     2220

tcatacgagg acatctccgc ctacctcctg tccaagaata acgccattga acctcggagc     2280

ttcagccaga acccacccgt gcttaagaga catcaacggg agatcactag gaccaccctg     2340

cagtcagacc aggaggaaat cgactacgat gacaccatct cggtcgagat gaagaaggag     2400

gactttgaca tctacgacga agatgaaaac cagagcccga ggtcgttcca aaagaaaacc     2460

cgccactact ttattgctgc tgtcgagcgg ctgtgggact acggaatgtc gtcctcgccg     2520

cacgtgctcc gcaaccgagc ccagagcggc tcggtgccgc aattcaagaa ggtcgtgttc     2580

caggagttca ctgacgggag cttcactcag cctttgtacc ggggagaact caatgaacat     2640

ctcggcctcc tcggacctta catcagagca gaagtggaag ataacatcat ggtcactttc     2700

cgtaaccaag ccagccgccc gtactcgttc tactcctccc tcatttctta cgaagaggac     2760

cagcggcagg gcgcagaacc gcgcaagaac ttcgtgaagc ccaacgaaac caagacctac     2820

ttctggaaag tgcagcatca tatggccccg actaaggacg agtttgactg caaagcctgg     2880

gcctacttct ccgatgtgga cttggagaag gacgtccact ccggcctcat cggtcccctg     2940

ctcgtgtgcc ataccaatac cctgaacccc gcacacggtc gccaggtcac cgtgcaggag     3000

ttcgctctgt tcttcactat cttcgacgaa actaagtcct ggtacttcac cgagaacatg     3060

gagaggaact gcagagcccc ctgtaacatc cagatggagg acccgacgtt caaggaaaac     3120

taccggttcc acgccattaa cggatacatc atggatacgc tgccgggtct tgtgatggcc     3180

caggatcaac ggatcagatg gtacttattg tcgatgggca gcaacgagaa catccactct     3240

attcacttct ccggtcatgt gttcactgtg cggaagaagg aagagtacaa gatggccctg     3300

tacaaccttt atcccggagt gttcgaaact gtggaaatgc tgccgtcgaa ggccggcatt     3360

tggcgcgtgg agtgtttgat tggagaacat ctccatgcgg ggatgtcaac cctgttcctg     3420

gtgtatagca acaagtgcca gactccgctt gggatggcgt caggacacat tagggatttc     3480

cagatcactg cgtccggcca gtacggccaa tgggccccta agctggcccg cctgcattac     3540

tccggatcca ttaacgcctg gtcaaccaag gagccattct cctggatcaa ggtggacctt     3600

ctggccccca tgattatcca cggaattaag acccaggggg cccggcagaa gttctcctca     3660

ctgtacatca gccagttcat aatcatgtac tccctggacg gaaagaagtg gcaaacctac     3720

agggggaaca gcaccggcac actgatggtc tttttcggaa atgtggactc ctccgggatt     3780

aagcataaca tcttcaaccc tccgattatc gctcggtaca ttagacttca ccctacccac     3840

tacagcattc gctccaccct gcggatggaa ctgatgggct gcgatctgaa ctcgtgcagc     3900

atgccgttgg gaatggagtc caaagcaatt tccgacgcgc agatcaccgc ctcgtcctac     3960

tttaccaaca tgttcgccac gtggtcaccg tccaaggccc ggctgcacct ccagggaaga     4020

tccaacgcat ggcggccaca ggtcaacaac cctaaggagt ggctccaggt ggacttccag     4080

aaaaccatga aggtcaccgg agtcacaacc cagggagtga agtcgctgct gacttctatg     4140

tacgtcaagg agttcctgat ctccagcagc caggacgggc accagtggac cctgttcttc     4200

caaaatggaa aggtcaaggt gtttcagggc aatcaggatt cattcacccc ggtggtgaac     4260

tcccttgatc cacccctcct gacccgctac cttcgcatcc acccacagtc ctgggtgcac     4320

cagatcgcgc tgaggatgga ggtcctggga tgcgaagccc aggacctgta ctga           4374


<210>  2
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-4

<400>  2
atgcagatcg agctgagcac gtgcttcttc ctgtgcctgc tgaggttctg cttcagcgcc       60

accaggaggt actacctggg cgccgtggag ctgagctggg actacatgca gagcgacctg      120

ggcgagctgc ccgtggacgc caggttcccc cccagggtgc ccaagagctt ccccttcaac      180

acgagcgtgg tgtacaagaa gaccctgttc gtggagttca ccgaccatct gttcaatatc      240

gccaagccca ggcccccctg gatggggctg ctggggccca cgatccaggc cgaggtgtac      300

gacaccgtgg tcatcaccct gaagaacatg gccagccacc ccgtgagcct gcacgccgtg      360

ggcgtgagct actggaaggc cagcgagggc gccgagtacg acgaccagac cagccagagg      420

gagaaggagg acgacaaggt gttccccggc ggcagccaca cctacgtgtg gcaggtgctg      480

aaggagaatg ggcccatggc cagcgacccc ctgtgcctga cctactctta cctgagccac      540

gtggatctgg tgaaggacct gaacagcggc ctgatcggcg ccctgctggt gtgcagggag      600

ggcagcctgg ccaaggagaa gacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcacagcgag accaagaaca gcctgatgca ggatagggac      720

gccgccagcg ccagggcctg gcccaagatg cacaccgtga acggctacgt gaacaggtct      780

ctgcccggcc tgatcggctg ccacaggaag agcgtgtact ggcacgtgat cggcatgggg      840

accacccccg aggtgcacag catcttcctg gagggccaca cgttcctggt gaggaatcac      900

aggcaggcca gcctggagat cagcccgatc accttcctga ccgcccagac cctgctgatg      960

gacctggggc agttcctgct gttctgccat atcagctctc accagcacga cggcatggag     1020

gcctacgtga aggtggatag ctgccccgag gagccccagc tgaggatgaa gaacaacgag     1080

gaggccgagg actacgacga cgacctgacc gacagcgaga tggacgtggt gaggttcgac     1140

gacgacaata gcccgagctt catccagatc aggagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcatt acatcgccgc cgaggaggag gattgggact acgcccccct ggtgctggcc     1260

cccgacgaca ggtcttacaa gagccagtac ctgaacaacg ggccccagag gatcggcagg     1320

aagtacaaga aggtgaggtt catggcctac accgacgaga ccttcaagac cagggaggcg     1380

atccagcacg agagcgggat cctggggccc ctgctgtacg gcgaggtggg cgacacgctg     1440

ctgatcatct tcaagaacca ggccagcagg ccgtacaata tctaccccca cgggatcacc     1500

gacgtgaggc ccctgtactc taggaggctg cccaagggcg tgaagcacct gaaggacttc     1560

cccatcctgc ccggcgagat cttcaagtac aagtggaccg tgaccgtgga ggacgggccc     1620

acgaagagcg accccaggtg cctgaccagg tactacagct ctttcgtgaa catggagagg     1680

gacctggcca gcggcctgat cgggcccctg ctgatctgct acaaggagag cgtggatcag     1740

aggggcaacc agatcatgag cgacaagagg aacgtgatcc tgttcagcgt gttcgacgag     1800

aataggtctt ggtacctgac cgagaatatc cagaggttcc tgcccaaccc cgccggcgtg     1860

cagctggagg atcccgagtt ccaggccagc aacatcatgc acagcatcaa cggctacgtg     1920

ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc     1980

atcggcgccc agaccgactt cctgagcgtg ttcttcagcg gctacacctt caagcacaag     2040

atggtgtacg aggataccct gaccctgttc cccttcagcg gcgagaccgt gttcatgagc     2100

atggagaacc ccggcctgtg gatcctgggc tgccataact ccgacttcag gaataggggc     2160

atgaccgccc tgctgaaggt gagctcttgc gacaagaaca ccggcgacta ctacgaggat     2220

agctacgagg atatcagcgc ctacctgctg agcaagaaca acgccatcga gcccaggtct     2280

ttcagccaga acccccccgt gctgaagagg caccagaggg agatcaccag gacgaccctg     2340

cagagcgacc aggaggagat cgactacgac gacacgatca gcgtggagat gaagaaggag     2400

gatttcgaca tctacgacga ggacgagaat cagagcccca ggtctttcca gaagaagacc     2460

aggcattact tcatcgccgc cgtggagagg ctgtgggact acggcatgag cagctctccc     2520

cacgtgctga ggaatagggc ccagagcggc agcgtgcccc agttcaagaa ggtggtgttc     2580

caggagttca ccgacggcag cttcacccag cccctgtaca ggggcgagct gaacgagcac     2640

ctgggcctgc tggggcccta catcagggcc gaggtggagg ataacatcat ggtgaccttc     2700

aggaatcagg ccagcaggcc ctatagcttc tatagctctc tgatcagcta cgaggaggat     2760

cagaggcagg gcgccgagcc caggaagaac ttcgtgaagc ccaacgagac caagacctac     2820

ttctggaagg tgcagcacca catggccccc acgaaggacg agttcgactg caaggcctgg     2880

gcctacttca gcgacgtgga tctggagaag gacgtgcaca gcggcctgat cgggcccctg     2940

ctggtgtgcc acaccaacac cctgaacccc gcccacggca ggcaggtgac cgtgcaggag     3000

ttcgccctgt tcttcaccat cttcgacgag accaagagct ggtacttcac cgagaatatg     3060

gagaggaatt gcagggcccc ctgcaatatc cagatggagg acccgacctt caaggagaat     3120

tacaggttcc acgccatcaa cggctacatc atggacacgc tgcccggcct ggtcatggcc     3180

caggatcaga ggatcaggtg gtatctgctg agcatgggga gcaacgagaa tatccacagc     3240

atccacttca gcggccacgt gttcaccgtg aggaagaagg aggagtacaa gatggccctg     3300

tacaatctgt accccggcgt gttcgagacc gtggagatgc tgcccagcaa ggccgggatc     3360

tggagggtgg agtgcctgat cggcgagcac ctgcacgccg gcatgagcac gctgttcctg     3420

gtgtactcta acaagtgcca gacccccctg gggatggcca gcggccacat cagggacttc     3480

cagatcaccg ccagcggcca gtacggccag tgggccccca agctggccag gctgcactat     3540

tccggaagca tcaacgcctg gagcacgaag gagcccttca gctggatcaa ggtggatctg     3600

ctggccccca tgatcatcca cgggatcaag acccagggcg ccaggcagaa gttcagctct     3660

ctgtatatca gccagttcat catcatgtac tctctggacg gcaagaagtg gcagacctac     3720

aggggcaaca gcaccggcac gctgatggtg ttcttcggca acgtggactc tagcgggatc     3780

aagcacaata tcttcaaccc ccccatcatc gccaggtaca tcaggctgca ccccacccat     3840

tactctatca ggtctaccct gaggatggag ctgatgggct gcgacctgaa cagctgcagc     3900

atgcccctgg ggatggagag caaggccatc agcgacgccc agatcaccgc cagctcttac     3960

ttcaccaaca tgttcgccac ctggagcccg agcaaggcca ggctgcacct gcagggcagg     4020

tctaacgcct ggaggcccca ggtgaacaac cccaaggagt ggctgcaggt ggatttccag     4080

aagaccatga aggtgaccgg cgtgaccacg cagggcgtga agagcctgct gaccagcatg     4140

tacgtgaagg agttcctgat cagctctagc caggacggcc accagtggac cctgttcttc     4200

cagaacggca aggtgaaggt gttccagggc aaccaggata gcttcacccc cgtggtgaac     4260

agcctggacc cccccctgct gaccaggtat ctgaggatcc acccccagag ctgggtgcac     4320

cagatcgccc tgaggatgga ggtgctgggc tgcgaggccc aggatctgta ttga           4374


<210>  3
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-52

<400>  3
atgcaaatcg aactgagcac ctgtttcttc ctctgcctgc tgagattctg tttctccgcg       60

acccgccgat actacctggg agcagtggag ctctcctggg attacatgca gagcgacctt      120

ggggagctgc ccgtggatgc caggttccct ccccgggtgc caaagtcgtt tccgttcaac      180

acctccgtgg tgtacaagaa aactctgttc gtggagttca ccgaccacct gttcaatatc      240

gccaagccca gacctccctg gatggggctg ttgggaccta ccatccaagc ggaggtgtac      300

gacactgtgg tcatcactct gaagaacatg gcctcgcatc ccgtgtccct gcacgccgtg      360

ggagtgtctt actggaaagc gtccgagggg gccgaatacg acgaccagac ctcgcagaga      420

gaaaaggaag atgacaaggt gttcccagga ggatcgcaca cctacgtgtg gcaagtgttg      480

aaggagaacg gcccaatggc ctccgacccg ctgtgcctga cctactcgta cctgtcccac      540

gtggacctcg tgaaggacct caactcggga ctgattggag ccctgctggt ctgcagggaa      600

ggctcactgg cgaaagaaaa gactcagacc ttgcacaagt tcattctgct gttcgctgtg      660

ttcgacgagg ggaagtcgtg gcacagcgag actaagaact ccctgatgca agatagagat      720

gccgcctccg cccgggcctg gcctaagatg cacaccgtga acggttacgt gaaccgctcc      780

ctccctggcc tgattggatg ccaccggaag tccgtgtact ggcacgtgat cgggatgggg      840

accacccccg aggtgcacag catcttcctg gaaggtcaca catttctcgt gcgcaaccac      900

cggcaggcct ccctggaaat cagccccatt accttcctca ctgcccagac tctgctgatg      960

gacctgggac agttcctgct gttctgccat atctcctccc accaacatga cggaatggag     1020

gcatacgtga aggtcgattc ctgccctgag gaaccccagc tccgcatgaa gaacaatgag     1080

gaagccgagg actacgacga cgacctgacg gatagcgaga tggatgtggt ccggttcgat     1140

gacgataaca gcccttcctt catccaaatt cgctcggtgg caaagaagca ccccaagacc     1200

tgggtgcatt acattgcggc ggaagaagag gactgggatt atgccccgct tgtcctcgct     1260

cctgacgacc ggagctacaa gagccagtac ctgaacaacg gtccacagag gatcggtaga     1320

aagtacaaga aggtccgctt catggcctat accgacgaaa ccttcaaaac tagagaggcc     1380

atccaacacg aatccggcat cctgggcccg ctcttgtacg gagaagtcgg cgacaccctt     1440

ctcattatct tcaagaacca ggcttcccgg ccgtacaaca tctatccgca tgggatcact     1500

gacgtgcgcc cactgtactc gcggcgcctg cccaagggtg tcaaacacct gaaggatttt     1560

ccgatccttc cgggagaaat cttcaagtac aagtggaccg tgaccgtgga agatggccca     1620

actaagtctg accctagatg cctcacccgc tactactcat ccttcgtcaa catggagcgc     1680

gacctggcca gcggactgat cggcccgctg ctgatttgct acaaggaatc agtggaccaa     1740

cggggaaacc agatcatgtc ggataagagg aacgtcatcc tcttctccgt gtttgacgaa     1800

aaccggtcgt ggtacctgac cgagaacatc cagaggttcc tgcccaaccc tgctggggtg     1860

cagctggagg accccgagtt ccaggccagc aacatcatgc acagcatcaa tggctacgtg     1920

ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc     1980

atcggcgccc agaccgactt cctgagcgtg ttcttctctg gctacacctt caagcacaag     2040

atggtgtatg aggacaccct gaccctgttc cccttcagcg gggagactgt cttcatgagc     2100

atggagaacc ctggcctgtg gatcctgggc tgccacaaca gcgacttcag gaacaggggc     2160

atgactgccc tgctgaaagt ctccagctgt gacaagaaca ccggggacta ctacgaggac     2220

agctacgagg acatcagcgc ctacctgctg agcaagaaca atgccatcga gcccaggagc     2280

ttctctcaga accccccagt gctgaagagg caccagaggg agatcaccag gaccaccctg     2340

cagtctgacc aggaggagat cgactatgat gacaccatca gcgtggagat gaagaaggag     2400

gacttcgaca tctacgacga ggacgagaac cagagcccca ggagcttcca gaagaagacc     2460

aggcactact tcattgctgc tgtggagagg ctgtgggact atggcatgtc cagcagcccc     2520

catgtgctga ggaacagggc ccagtctggc agcgtgcccc agttcaagaa agtcgtgttc     2580

caggagttca ccgacggcag cttcacccag cccctgtaca gaggggagct gaacgagcac     2640

ctgggcctgc tgggccccta catcagggcc gaggtggagg acaacatcat ggtgaccttc     2700

aggaaccagg ccagcaggcc ctacagcttc tacagcagcc tgatcagcta cgaggaggac     2760

cagaggcagg gggctgagcc caggaagaac tttgtgaagc ccaatgaaac caagacctac     2820

ttctggaagg tgcagcacca catggccccc accaaggacg agttcgactg caaggcctgg     2880

gcctacttct ctgacgtgga cctggagaag gacgtgcact ctggcctgat tggccccctg     2940

ctggtgtgcc acaccaacac cctgaaccct gcccatggca ggcaggtgac tgtgcaggag     3000

ttcgccctgt tcttcaccat cttcgatgaa accaagagct ggtacttcac tgagaacatg     3060

gagaggaact gcagggcccc ctgcaacatc cagatggagg accccacctt caaggagaac     3120

tacaggttcc atgccatcaa tggctacatc atggacaccc tgcctggcct ggtcatggcc     3180

caggaccaga ggatcaggtg gtatctgctg agcatgggca gcaacgagaa catccacagc     3240

atccacttct ctggccacgt gttcactgtg aggaagaagg aggagtacaa gatggccctg     3300

tacaacctgt accctggggt gttcgaaacc gtggagatgc tgcccagcaa ggccggcatc     3360

tggagggtgg agtgcctgat tggggagcac ctgcacgccg gcatgagcac cctgttcctg     3420

gtgtacagca acaagtgcca gacccccctg ggcatggcct ctggccacat cagggacttc     3480

cagatcactg cctctggcca gtacggccag tgggccccca agctggccag gctgcactac     3540

tccggaagca tcaatgcctg gagcaccaag gagcccttca gctggatcaa agtggacctg     3600

ctggccccca tgatcatcca cggcatcaag acccaggggg ccaggcagaa gttctccagc     3660

ctgtacatca gccagttcat catcatgtac agcctggacg gcaagaagtg gcagacctac     3720

aggggcaaca gcaccggcac cctgatggtg ttcttcggca acgtggacag cagcggcatc     3780

aagcacaaca tcttcaaccc ccccatcatc gccagataca tcaggctgca ccccacccac     3840

tacagcatca ggagcaccct gaggatggag ctgatgggct gtgacctgaa cagctgcagc     3900

atgcccctgg gcatggagag caaggccatc tctgacgccc agatcactgc ctccagctac     3960

ttcaccaaca tgtttgccac ctggagcccc agcaaggcca ggctgcacct gcagggcagg     4020

agcaatgcct ggaggcccca ggtcaacaac cccaaggagt ggctgcaggt ggacttccag     4080

aagaccatga aggtgactgg ggtgaccacc cagggggtga agagcctgct gaccagcatg     4140

tacgtgaagg agttcctgat ctccagcagc caggacggcc accagtggac cctgttcttc     4200

cagaatggca aggtgaaggt gttccagggc aaccaggaca gcttcacccc tgtggtcaac     4260

agcctggacc cccccctgct gaccagatac ctgaggatcc acccccagag ctgggtgcac     4320

cagatcgccc tgaggatgga ggtgctgggc tgtgaggccc aggacctgta ctga           4374


<210>  4
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-62

<400>  4
atgcagattg agctgtccac ttgtttcttc ctgtgcctcc tgcgcttctg tttctccgcc       60

actcgccggt actaccttgg agccgtggag ctttcatggg actacatgca gagcgacctg      120

ggcgaactcc ccgtggatgc cagattcccc ccccgcgtgc caaagtcctt cccctttaac      180

acctccgtgg tgtacaagaa aaccctcttt gtcgagttca ctgaccacct gttcaacatc      240

gccaagccgc gcccaccttg gatgggcctc ctgggaccga ccattcaagc tgaagtgtac      300

gacaccgtgg tgatcaccct gaagaacatg gcgtcccacc ccgtgtccct gcatgcggtc      360

ggagtgtcct actggaaggc ctccgaagga gctgagtacg acgaccagac tagccagcgg      420

gaaaaggagg acgataaagt gttcccgggc ggctcgcata cttacgtgtg gcaagtcctg      480

aaggaaaacg gacctatggc atccgatcct ctgtgcctga cttactccta cctttcccat      540

gtggacctcg tgaaggacct gaacagcggg ctgattggtg cacttctcgt gtgccgcgaa      600

ggttcgctcg ctaaggaaaa gacccagacc ctccataagt tcatcctttt gttcgctgtg      660

ttcgatgaag gaaagtcatg gcattccgaa actaagaact cgctgatgca ggaccgggat      720

gccgcctcag cccgcgcctg gcctaaaatg catacagtca acggatacgt gaatcggtca      780

ctgcccgggc tcatcggttg tcacagaaag tccgtgtact ggcacgtcat cggcatgggc      840

actacgcctg aagtgcactc catcttcctg gaagggcaca ccttcctcgt gcgcaaccac      900

cgccaggcct ctctggaaat ctccccgatt acctttctga ccgcccagac tctgctcatg      960

gacctggggc agttccttct cttctgccac atctccagcc atcagcacga cggaatggag     1020

gcctacgtga aggtggactc atgcccggaa gaacctcagt tgcggatgaa gaacaacgag     1080

gaggccgagg actatgacga cgatttgact gactccgaga tggacgtcgt gcggttcgat     1140

gacgacaaca gccccagctt catccagatt cgcagcgtgg ccaagaagca ccccaaaacc     1200

tgggtgcact acatcgcggc cgaggaagaa gattgggact acgccccgtt ggtgctggca     1260

cccgatgacc ggtcgtacaa gtcccagtat ctgaacaatg gtccgcagcg gattggcaga     1320

aagtacaaga aagtgcggtt catggcgtac actgacgaaa cgtttaagac ccgggaggcc     1380

attcaacatg agagcggcat tctgggacca ctgctgtacg gagaggtcgg cgataccctg     1440

ctcatcatct tcaaaaacca ggcctcccgg ccttacaaca tctaccctca cggaatcacc     1500

gacgtgcggc cactctactc gcggcgcctg ccgaagggcg tcaagcacct gaaagacttc     1560

cctatcctgc cgggcgaaat cttcaagtat aagtggaccg tcaccgtgga ggacgggccc     1620

accaagagcg atcctaggtg tctgactcgg tactactcca gcttcgtgaa catggaacgg     1680

gacctggcat cgggactcat tggaccgctg ctgatctgct acaaagagtc ggtggatcaa     1740

cgcggcaacc agatcatgtc cgacaagcgc aacgtgatcc tgttctccgt gtttgatgaa     1800

aacagatcct ggtacctgac cgagaacatc cagaggttcc tgcccaaccc tgctggggtg     1860

cagctggagg accccgagtt ccaggccagc aacatcatgc acagcatcaa tggctacgtg     1920

ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc     1980

atcggcgccc agaccgactt cctgagcgtg ttcttctctg gctacacctt caagcacaag     2040

atggtgtatg aggacaccct gaccctgttc cccttcagcg gggagactgt cttcatgagc     2100

atggagaacc ctggcctgtg gatcctgggc tgccacaaca gcgacttcag gaacaggggc     2160

atgactgccc tgctgaaagt ctccagctgt gacaagaaca ccggggacta ctacgaggac     2220

agctacgagg acatcagcgc ctacctgctg agcaagaaca atgccatcga gcccaggagc     2280

ttctctcaga accccccagt gctgaagagg caccagaggg agatcaccag gaccaccctg     2340

cagtctgacc aggaggagat cgactatgat gacaccatca gcgtggagat gaagaaggag     2400

gacttcgaca tctacgacga ggacgagaac cagagcccca ggagcttcca gaagaagacc     2460

aggcactact tcattgctgc tgtggagagg ctgtgggact atggcatgtc cagcagcccc     2520

catgtgctga ggaacagggc ccagtctggc agcgtgcccc agttcaagaa agtcgtgttc     2580

caggagttca ccgacggcag cttcacccag cccctgtaca gaggggagct gaacgagcac     2640

ctgggcctgc tgggccccta catcagggcc gaggtggagg acaacatcat ggtgaccttc     2700

aggaaccagg ccagcaggcc ctacagcttc tacagcagcc tgatcagcta cgaggaggac     2760

cagaggcagg gggctgagcc caggaagaac tttgtgaagc ccaatgaaac caagacctac     2820

ttctggaagg tgcagcacca catggccccc accaaggacg agttcgactg caaggcctgg     2880

gcctacttct ctgacgtgga cctggagaag gacgtgcact ctggcctgat tggccccctg     2940

ctggtgtgcc acaccaacac cctgaaccct gcccatggca ggcaggtgac tgtgcaggag     3000

ttcgccctgt tcttcaccat cttcgatgaa accaagagct ggtacttcac tgagaacatg     3060

gagaggaact gcagggcccc ctgcaacatc cagatggagg accccacctt caaggagaac     3120

tacaggttcc atgccatcaa tggctacatc atggacaccc tgcctggcct ggtcatggcc     3180

caggaccaga ggatcaggtg gtatctgctg agcatgggca gcaacgagaa catccacagc     3240

atccacttct ctggccacgt gttcactgtg aggaagaagg aggagtacaa gatggccctg     3300

tacaacctgt accctggggt gttcgaaacc gtggagatgc tgcccagcaa ggccggcatc     3360

tggagggtgg agtgcctgat tggggagcac ctgcacgccg gcatgagcac cctgttcctg     3420

gtgtacagca acaagtgcca gacccccctg ggcatggcct ctggccacat cagggacttc     3480

cagatcactg cctctggcca gtacggccag tgggccccca agctggccag gctgcactac     3540

tccggaagca tcaatgcctg gagcaccaag gagcccttca gctggatcaa agtggacctg     3600

ctggccccca tgatcatcca cggcatcaag acccaggggg ccaggcagaa gttctccagc     3660

ctgtacatca gccagttcat catcatgtac agcctggacg gcaagaagtg gcagacctac     3720

aggggcaaca gcaccggcac cctgatggtg ttcttcggca acgtggacag cagcggcatc     3780

aagcacaaca tcttcaaccc ccccatcatc gccagataca tcaggctgca ccccacccac     3840

tacagcatca ggagcaccct gaggatggag ctgatgggct gtgacctgaa cagctgcagc     3900

atgcccctgg gcatggagag caaggccatc tctgacgccc agatcactgc ctccagctac     3960

ttcaccaaca tgtttgccac ctggagcccc agcaaggcca ggctgcacct gcagggcagg     4020

agcaatgcct ggaggcccca ggtcaacaac cccaaggagt ggctgcaggt ggacttccag     4080

aagaccatga aggtgactgg ggtgaccacc cagggggtga agagcctgct gaccagcatg     4140

tacgtgaagg agttcctgat ctccagcagc caggacggcc accagtggac cctgttcttc     4200

cagaatggca aggtgaaggt gttccagggc aaccaggaca gcttcacccc tgtggtcaac     4260

agcctggacc cccccctgct gaccagatac ctgaggatcc acccccagag ctgggtgcac     4320

cagatcgccc tgaggatgga ggtgctgggc tgtgaggccc aggacctgta ctga           4374


<210>  5
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-25

<400>  5
atgcagattg agctgagcac ctgcttcttc ctgtgcctgc tgaggttctg cttctctgcc       60

accaggagat actacctggg cgccgtggag ctgagctggg actacatgca gtctgacctg      120

ggcgagctgc cagtggacgc caggttcccc cccagagtgc ccaagagctt ccccttcaac      180

accagcgtgg tgtacaagaa gaccctgttc gtggagttca ctgaccacct gttcaacatc      240

gccaagccca ggcccccctg gatgggcctg ctgggcccca ccatccaggc cgaggtgtac      300

gacaccgtgg tcatcaccct gaagaacatg gccagccacc ccgtctccct gcacgccgtg      360

ggggtgagct actggaaggc ctctgagggc gccgagtacg acgaccagac cagccagagg      420

gagaaggagg acgacaaggt gttccctggg ggcagccaca cctacgtgtg gcaggtcctg      480

aaggagaacg gccccatggc ctctgacccc ctgtgcctga cctacagcta cctgagccac      540

gtggacctgg tgaaggacct gaactctggc ctgattgggg ccctgctggt gtgcagggag      600

ggcagcctgg ccaaggagaa gacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcactctgaa accaagaaca gcctgatgca ggacagggac      720

gccgcctctg ccagggcctg gcccaagatg cacaccgtca acggctacgt caacaggagc      780

ctgcctggcc tgattggctg ccacaggaag agcgtgtact ggcatgtgat cggcatgggc      840

accacccctg aggtgcacag catcttcctg gagggccaca ccttcctggt caggaaccac      900

aggcaggcca gcctggagat cagccccatc accttcctga ccgcccagac cctgctgatg      960

gacctgggcc agttcctgct gttctgccac atctccagcc accagcacga cggcatggag     1020

gcctacgtga aagtggacag ctgccctgag gagccccagc tgaggatgaa gaacaacgag     1080

gaggccgagg actatgatga cgacctgacc gacagcgaga tggacgtggt caggttcgac     1140

gacgacaaca gccccagctt catccagatc aggagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact acatcgctgc tgaggaggag gactgggact atgcccccct ggtgctggcc     1260

cctgatgaca ggagctacaa gagccagtac ctgaacaatg gcccccagag gattggcagg     1320

aagtacaaga aagtcaggtt catggcctac actgatgaaa ccttcaagac cagggaggcc     1380

atccagcatg agtctggcat cctgggcccc ctgctgtacg gggaggtggg ggacaccctg     1440

ctgatcatct tcaagaacca ggccagcagg ccctacaaca tctaccccca tggcatcacc     1500

gacgtgaggc ccctgtacag caggaggctg cctaaggggg tgaagcacct gaaagacttc     1560

cccatcctgc ctggggagat cttcaagtac aagtggactg tgactgtgga ggacggcccc     1620

accaagagcg accccaggtg cctgaccaga tactacagca gcttcgtcaa catggagagg     1680

gacctggcct ctggcctgat tggccccctg ctgatctgct acaaggagtc tgtggaccag     1740

aggggcaacc agatcatgag cgacaagagg aacgtgatcc tgttctctgt cttcgacgag     1800

aacaggagct ggtacctgac tgaaaacatc cagcggttcc tccccaaccc cgcgggcgtg     1860

cagctggaag atcctgagtt tcaggcatca aacatcatgc actccattaa cggctacgtg     1920

ttcgattcgc tgcagctgag cgtgtgtctg cacgaagtgg cctactggta catcctgtcc     1980

attggtgccc agactgactt cctgtccgtg tttttctccg gctacacgtt caagcacaag     2040

atggtgtacg aggacaccct gaccctcttc cctttttccg gcgaaactgt gtttatgagc     2100

atggagaatc ccggcctgtg gatcttgggc tgccacaaca gcgacttccg taacagagga     2160

atgactgcgc tgctcaaggt gtccagctgc gacaagaaca ccggagacta ttatgaggac     2220

tcatacgagg acatctccgc ctacctcctg tccaagaata acgccattga acctcggagc     2280

ttcagccaga acccacccgt gcttaagaga catcaacggg agatcactag gaccaccctg     2340

cagtcagacc aggaggaaat cgactacgat gacaccatct cggtcgagat gaagaaggag     2400

gactttgaca tctacgacga agatgaaaac cagagcccga ggtcgttcca aaagaaaacc     2460

cgccactact ttattgctgc tgtcgagcgg ctgtgggact acggaatgtc gtcctcgccg     2520

cacgtgctcc gcaaccgagc ccagagcggc tcggtgccgc aattcaagaa ggtcgtgttc     2580

caggagttca ctgacgggag cttcactcag cctttgtacc ggggagaact caatgaacat     2640

ctcggcctcc tcggacctta catcagagca gaagtggaag ataacatcat ggtcactttc     2700

cgtaaccaag ccagccgccc gtactcgttc tactcctccc tcatttctta cgaagaggac     2760

cagcggcagg gcgcagaacc gcgcaagaac ttcgtgaagc ccaacgaaac caagacctac     2820

ttctggaaag tgcagcatca tatggccccg actaaggacg agtttgactg caaagcctgg     2880

gcctacttct ccgatgtgga cttggagaag gacgtccact ccggcctcat cggtcccctg     2940

ctcgtgtgcc ataccaatac cctgaacccc gcacacggtc gccaggtcac cgtgcaggag     3000

ttcgctctgt tcttcactat cttcgacgaa actaagtcct ggtacttcac cgagaacatg     3060

gagaggaact gcagagcccc ctgtaacatc cagatggagg acccgacgtt caaggaaaac     3120

taccggttcc acgccattaa cggatacatc atggatacgc tgccgggtct tgtgatggcc     3180

caggatcaac ggatcagatg gtacttattg tcgatgggca gcaacgagaa catccactct     3240

attcacttct ccggtcatgt gttcactgtg cggaagaagg aagagtacaa gatggccctg     3300

tacaaccttt atcccggagt gttcgaaact gtggaaatgc tgccgtcgaa ggccggcatt     3360

tggcgcgtgg agtgtttgat tggagaacat ctccatgcgg ggatgtcaac cctgttcctg     3420

gtgtatagca acaagtgcca gactccgctt gggatggcgt caggacacat tagggatttc     3480

cagatcactg cgtccggcca gtacggccaa tgggccccta agctggcccg cctgcattac     3540

tccggatcca ttaacgcctg gtcaaccaag gagccattct cctggatcaa ggtggacctt     3600

ctggccccca tgattatcca cggaattaag acccaggggg cccggcagaa gttctcctca     3660

ctgtacatca gccagttcat aatcatgtac tccctggacg gaaagaagtg gcaaacctac     3720

agggggaaca gcaccggcac actgatggtc tttttcggaa atgtggactc ctccgggatt     3780

aagcataaca tcttcaaccc tccgattatc gctcggtaca ttagacttca ccctacccac     3840

tacagcattc gctccaccct gcggatggaa ctgatgggct gcgatctgaa ctcgtgcagc     3900

atgccgttgg gaatggagtc caaagcaatt tccgacgcgc agatcaccgc ctcgtcctac     3960

tttaccaaca tgttcgccac gtggtcaccg tccaaggccc ggctgcacct ccagggaaga     4020

tccaacgcat ggcggccaca ggtcaacaac cctaaggagt ggctccaggt ggacttccag     4080

aaaaccatga aggtcaccgg agtcacaacc cagggagtga agtcgctgct gacttctatg     4140

tacgtcaagg agttcctgat ctccagcagc caggacgggc accagtggac cctgttcttc     4200

caaaatggaa aggtcaaggt gtttcagggc aatcaggatt cattcacccc ggtggtgaac     4260

tcccttgatc cacccctcct gacccgctac cttcgcatcc acccacagtc ctgggtgcac     4320

cagatcgcgc tgaggatgga ggtcctggga tgcgaagccc aggacctgta ctga           4374


<210>  6
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-26

<400>  6
atgcagattg agctgagcac ctgcttcttc ctgtgcctgc tgaggttctg cttctctgcc       60

accaggagat actacctggg cgccgtggag ctgagctggg actacatgca gtctgacctg      120

ggcgagctgc cagtggacgc caggttcccc cccagagtgc ccaagagctt ccccttcaac      180

accagcgtgg tgtacaagaa gaccctgttc gtggagttca ctgaccacct gttcaacatc      240

gccaagccca ggcccccctg gatgggcctg ctgggcccca ccatccaggc cgaggtgtac      300

gacaccgtgg tcatcaccct gaagaacatg gccagccacc ccgtctccct gcacgccgtg      360

ggggtgagct actggaaggc ctctgagggc gccgagtacg acgaccagac cagccagagg      420

gagaaggagg acgacaaggt gttccctggg ggcagccaca cctacgtgtg gcaggtcctg      480

aaggagaacg gccccatggc ctctgacccc ctgtgcctga cctacagcta cctgagccac      540

gtggacctgg tgaaggacct gaactctggc ctgattgggg ccctgctggt gtgcagggag      600

ggcagcctgg ccaaggagaa gacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcactctgaa accaagaaca gcctgatgca ggacagggac      720

gccgcctctg ccagggcctg gcccaagatg cacaccgtca acggctacgt caacaggagc      780

ctgcctggcc tgattggctg ccacaggaag agcgtgtact ggcatgtgat cggcatgggc      840

accacccctg aggtgcacag catcttcctg gagggccaca ccttcctggt caggaaccac      900

aggcaggcca gcctggagat cagccccatc accttcctga ccgcccagac cctgctgatg      960

gacctgggcc agttcctgct gttctgccac atctccagcc accagcacga cggcatggag     1020

gcctacgtga aagtggacag ctgccctgag gagccccagc tgaggatgaa gaacaacgag     1080

gaggccgagg actatgatga cgacctgacc gacagcgaga tggacgtggt caggttcgac     1140

gacgacaaca gccccagctt catccagatc aggagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact acatcgctgc tgaggaggag gactgggact atgcccccct ggtgctggcc     1260

cctgatgaca ggagctacaa gagccagtac ctgaacaatg gcccccagag gattggcagg     1320

aagtacaaga aagtcaggtt catggcctac actgatgaaa ccttcaagac cagggaggcc     1380

atccagcatg agtctggcat cctgggcccc ctgctgtacg gggaggtggg ggacaccctg     1440

ctgatcatct tcaagaacca ggccagcagg ccctacaaca tctaccccca tggcatcacc     1500

gacgtgaggc ccctgtacag caggaggctg cctaaggggg tgaagcacct gaaagacttc     1560

cccatcctgc ctggggagat cttcaagtac aagtggactg tgactgtgga ggacggcccc     1620

accaagagcg accccaggtg cctgaccaga tactacagca gcttcgtcaa catggagagg     1680

gacctggcct ctggcctgat tggccccctg ctgatctgct acaaggagtc tgtggaccag     1740

aggggcaacc agatcatgag cgacaagagg aacgtgatcc tgttctctgt cttcgacgag     1800

aacaggagct ggtacctcac tgaaaacatc cagaggttcc tcccaaaccc cgcaggagtg     1860

caactggagg accctgagtt tcaggcctcg aatatcatgc actcgattaa cggttacgtg     1920

ttcgactcgc tgcagctgag cgtgtgcctc catgaagtcg cttactggta cattctgtcc     1980

atcggcgccc agactgactt cctgagcgtg ttcttttccg gttacacctt taagcacaag     2040

atggtgtacg aagataccct gaccctgttc cctttctccg gcgaaacggt gttcatgtcg     2100

atggagaacc cgggtctgtg gattctggga tgccacaaca gcgactttcg gaaccgcgga     2160

atgactgccc tgctgaaggt gtcctcatgc gacaagaaca ccggagacta ctacgaggac     2220

tcctacgagg atatctcagc ctacctcctg tccaagaaca acgcgatcga gccgcgcagc     2280

ttcagccaga acccgcctgt gctgaagagg caccagcgag aaattacccg gaccaccctc     2340

caatcggatc aggaggaaat cgactacgac gacaccatct cggtggaaat gaagaaggaa     2400

gatttcgata tctacgacga ggacgaaaat cagtcccctc gctcattcca aaagaaaact     2460

agacactact ttatcgccgc ggtggaaaga ctgtgggact atggaatgtc atccagccct     2520

cacgtccttc ggaaccgggc ccagagcgga tcggtgcctc agttcaagaa agtggtgttc     2580

caggagttca ccgacggcag cttcacccag ccgctgtacc ggggagaact gaacgaacac     2640

ctgggcctgc tcggtcccta catccgcgcg gaagtggagg ataacatcat ggtgaccttc     2700

cgtaaccaag catccagacc ttactccttc tattcctccc tgatctcata cgaggaggac     2760

cagcgccaag gcgccgagcc ccgcaagaac ttcgtcaagc ccaacgagac taagacctac     2820

ttctggaagg tccaacacca tatggccccg accaaggatg agtttgactg caaggcctgg     2880

gcctacttct ccgacgtgga ccttgagaag gatgtccatt ccggcctgat cgggccgctg     2940

ctcgtgtgtc acaccaacac cctgaaccca gcgcatggac gccaggtcac cgtccaggag     3000

tttgctctgt tcttcaccat ttttgacgaa actaagtcct ggtacttcac cgagaatatg     3060

gagcgaaact gtagagcgcc ctgcaatatc cagatggaag atccgacttt caaggagaac     3120

tatagattcc acgccatcaa cgggtacatc atggatactc tgccggggct ggtcatggcc     3180

caggatcaga ggattcggtg gtacttgctg tcaatgggat cgaacgaaaa cattcactcc     3240

attcacttct ccggtcacgt gttcactgtg cgcaagaagg aggagtacaa gatggcgctg     3300

tacaatctgt accccggggt gttcgaaact gtggagatgc tgccgtccaa ggccggcatc     3360

tggagagtgg agtgcctgat cggagagcac ctccacgcgg ggatgtccac cctcttcctg     3420

gtgtactcga ataagtgcca gaccccgctg ggcatggcct cgggccacat cagagacttc     3480

cagatcacag caagcggaca atacggccaa tgggcgccga agctggcccg cttgcactac     3540

tccggatcga tcaacgcatg gtccaccaag gaaccgttct cgtggattaa ggtggacctc     3600

ctggccccta tgattatcca cggaattaag acccagggcg ccaggcagaa gttctcctcc     3660

ctgtacatct cgcaattcat catcatgtac agcctggacg ggaagaagtg gcagacttac     3720

aggggaaact ccaccggcac cctgatggtc tttttcggca acgtggattc ctccggcatt     3780

aagcacaaca tcttcaaccc accgatcata gccagatata ttaggctcca ccccactcac     3840

tactcaatcc gctcaactct tcggatggaa ctcatggggt gcgacctgaa ctcctgctcc     3900

atgccgttgg ggatggaatc aaaggctatt agcgacgccc agatcaccgc gagctcctac     3960

ttcactaaca tgttcgccac ctggagcccc tccaaggcca ggctgcactt gcagggacgg     4020

tcaaatgcct ggcggccgca agtgaacaat ccgaaggaat ggcttcaagt ggatttccaa     4080

aagaccatga aagtgaccgg agtcaccacc cagggagtga agtcccttct gacctcgatg     4140

tatgtgaagg agttcctgat tagcagcagc caggacgggc accagtggac cctgttcttc     4200

caaaacggaa aggtcaaggt gttccagggg aaccaggact cgttcacacc cgtggtgaac     4260

tccctggacc ccccactgct gacgcggtac ttgaggattc atcctcagtc ctgggtccat     4320

cagattgcat tgcgaatgga agtcctgggc tgcgaggccc aggacctgta ctga           4374


<210>  7
<211>  1734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-52-NT58

<400>  7
gcgacccgcc gatactacct gggagcagtg gagctctcct gggattacat gcagagcgac       60

cttggggagc tgcccgtgga tgccaggttc cctccccggg tgccaaagtc gtttccgttc      120

aacacctccg tggtgtacaa gaaaactctg ttcgtggagt tcaccgacca cctgttcaat      180

atcgccaagc ccagacctcc ctggatgggg ctgttgggac ctaccatcca agcggaggtg      240

tacgacactg tggtcatcac tctgaagaac atggcctcgc atcccgtgtc cctgcacgcc      300

gtgggagtgt cttactggaa agcgtccgag ggggccgaat acgacgacca gacctcgcag      360

agagaaaagg aagatgacaa ggtgttccca ggaggatcgc acacctacgt gtggcaagtg      420

ttgaaggaga acggcccaat ggcctccgac ccgctgtgcc tgacctactc gtacctgtcc      480

cacgtggacc tcgtgaagga cctcaactcg ggactgattg gagccctgct ggtctgcagg      540

gaaggctcac tggcgaaaga aaagactcag accttgcaca agttcattct gctgttcgct      600

gtgttcgacg aggggaagtc gtggcacagc gagactaaga actccctgat gcaagataga      660

gatgccgcct ccgcccgggc ctggcctaag atgcacaccg tgaacggtta cgtgaaccgc      720

tccctccctg gcctgattgg atgccaccgg aagtccgtgt actggcacgt gatcgggatg      780

gggaccaccc ccgaggtgca cagcatcttc ctggaaggtc acacatttct cgtgcgcaac      840

caccggcagg cctccctgga aatcagcccc attaccttcc tcactgccca gactctgctg      900

atggacctgg gacagttcct gctgttctgc catatctcct cccaccaaca tgacggaatg      960

gaggcatacg tgaaggtcga ttcctgccct gaggaacccc agctccgcat gaagaacaat     1020

gaggaagccg aggactacga cgacgacctg acggatagcg agatggatgt ggtccggttc     1080

gatgacgata acagcccttc cttcatccaa attcgctcgg tggcaaagaa gcaccccaag     1140

acctgggtgc attacattgc ggcggaagaa gaggactggg attatgcccc gcttgtcctc     1200

gctcctgacg accggagcta caagagccag tacctgaaca acggtccaca gaggatcggt     1260

agaaagtaca agaaggtccg cttcatggcc tataccgacg aaaccttcaa aactagagag     1320

gccatccaac acgaatccgg catcctgggc ccgctcttgt acggagaagt cggcgacacc     1380

cttctcatta tcttcaagaa ccaggcttcc cggccgtaca acatctatcc gcatgggatc     1440

actgacgtgc gcccactgta ctcgcggcgc ctgcccaagg gtgtcaaaca cctgaaggat     1500

tttccgatcc ttccgggaga aatcttcaag tacaagtgga ccgtgaccgt ggaagatggc     1560

ccaactaagt ctgaccctag atgcctcacc cgctactact catccttcgt caacatggag     1620

cgcgacctgg ccagcggact gatcggcccg ctgctgattt gctacaagga atcagtggac     1680

caacggggaa accagatcat gtcggataag aggaacgtca tcctcttctc cgtg           1734


<210>  8
<211>  2583
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-52-CT

<400>  8
tttgacgaaa accggtcgtg gtacctgacc gagaacatcc agaggttcct gcccaaccct       60

gctggggtgc agctggagga ccccgagttc caggccagca acatcatgca cagcatcaat      120

ggctacgtgt tcgacagcct gcagctgagc gtgtgcctgc acgaggtggc ctactggtac      180

atcctgagca tcggcgccca gaccgacttc ctgagcgtgt tcttctctgg ctacaccttc      240

aagcacaaga tggtgtatga ggacaccctg accctgttcc ccttcagcgg ggagactgtc      300

ttcatgagca tggagaaccc tggcctgtgg atcctgggct gccacaacag cgacttcagg      360

aacaggggca tgactgccct gctgaaagtc tccagctgtg acaagaacac cggggactac      420

tacgaggaca gctacgagga catcagcgcc tacctgctga gcaagaacaa tgccatcgag      480

cccaggagct tctctcagaa ccccccagtg ctgaagaggc accagaggga gatcaccagg      540

accaccctgc agtctgacca ggaggagatc gactatgatg acaccatcag cgtggagatg      600

aagaaggagg acttcgacat ctacgacgag gacgagaacc agagccccag gagcttccag      660

aagaagacca ggcactactt cattgctgct gtggagaggc tgtgggacta tggcatgtcc      720

agcagccccc atgtgctgag gaacagggcc cagtctggca gcgtgcccca gttcaagaaa      780

gtcgtgttcc aggagttcac cgacggcagc ttcacccagc ccctgtacag aggggagctg      840

aacgagcacc tgggcctgct gggcccctac atcagggccg aggtggagga caacatcatg      900

gtgaccttca ggaaccaggc cagcaggccc tacagcttct acagcagcct gatcagctac      960

gaggaggacc agaggcaggg ggctgagccc aggaagaact ttgtgaagcc caatgaaacc     1020

aagacctact tctggaaggt gcagcaccac atggccccca ccaaggacga gttcgactgc     1080

aaggcctggg cctacttctc tgacgtggac ctggagaagg acgtgcactc tggcctgatt     1140

ggccccctgc tggtgtgcca caccaacacc ctgaaccctg cccatggcag gcaggtgact     1200

gtgcaggagt tcgccctgtt cttcaccatc ttcgatgaaa ccaagagctg gtacttcact     1260

gagaacatgg agaggaactg cagggccccc tgcaacatcc agatggagga ccccaccttc     1320

aaggagaact acaggttcca tgccatcaat ggctacatca tggacaccct gcctggcctg     1380

gtcatggccc aggaccagag gatcaggtgg tatctgctga gcatgggcag caacgagaac     1440

atccacagca tccacttctc tggccacgtg ttcactgtga ggaagaagga ggagtacaag     1500

atggccctgt acaacctgta ccctggggtg ttcgaaaccg tggagatgct gcccagcaag     1560

gccggcatct ggagggtgga gtgcctgatt ggggagcacc tgcacgccgg catgagcacc     1620

ctgttcctgg tgtacagcaa caagtgccag acccccctgg gcatggcctc tggccacatc     1680

agggacttcc agatcactgc ctctggccag tacggccagt gggcccccaa gctggccagg     1740

ctgcactact ccggaagcat caatgcctgg agcaccaagg agcccttcag ctggatcaaa     1800

gtggacctgc tggcccccat gatcatccac ggcatcaaga cccagggggc caggcagaag     1860

ttctccagcc tgtacatcag ccagttcatc atcatgtaca gcctggacgg caagaagtgg     1920

cagacctaca ggggcaacag caccggcacc ctgatggtgt tcttcggcaa cgtggacagc     1980

agcggcatca agcacaacat cttcaacccc cccatcatcg ccagatacat caggctgcac     2040

cccacccact acagcatcag gagcaccctg aggatggagc tgatgggctg tgacctgaac     2100

agctgcagca tgcccctggg catggagagc aaggccatct ctgacgccca gatcactgcc     2160

tccagctact tcaccaacat gtttgccacc tggagcccca gcaaggccag gctgcacctg     2220

cagggcagga gcaatgcctg gaggccccag gtcaacaacc ccaaggagtg gctgcaggtg     2280

gacttccaga agaccatgaa ggtgactggg gtgaccaccc agggggtgaa gagcctgctg     2340

accagcatgt acgtgaagga gttcctgatc tccagcagcc aggacggcca ccagtggacc     2400

ctgttcttcc agaatggcaa ggtgaaggtg ttccagggca accaggacag cttcacccct     2460

gtggtcaaca gcctggaccc ccccctgctg accagatacc tgaggatcca cccccagagc     2520

tgggtgcacc agatcgccct gaggatggag gtgctgggct gtgaggccca ggacctgtac     2580

tga                                                                   2583


<210>  9
<211>  1734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-62-NT58

<400>  9
gccactcgcc ggtactacct tggagccgtg gagctttcat gggactacat gcagagcgac       60

ctgggcgaac tccccgtgga tgccagattc cccccccgcg tgccaaagtc cttccccttt      120

aacacctccg tggtgtacaa gaaaaccctc tttgtcgagt tcactgacca cctgttcaac      180

atcgccaagc cgcgcccacc ttggatgggc ctcctgggac cgaccattca agctgaagtg      240

tacgacaccg tggtgatcac cctgaagaac atggcgtccc accccgtgtc cctgcatgcg      300

gtcggagtgt cctactggaa ggcctccgaa ggagctgagt acgacgacca gactagccag      360

cgggaaaagg aggacgataa agtgttcccg ggcggctcgc atacttacgt gtggcaagtc      420

ctgaaggaaa acggacctat ggcatccgat cctctgtgcc tgacttactc ctacctttcc      480

catgtggacc tcgtgaagga cctgaacagc gggctgattg gtgcacttct cgtgtgccgc      540

gaaggttcgc tcgctaagga aaagacccag accctccata agttcatcct tttgttcgct      600

gtgttcgatg aaggaaagtc atggcattcc gaaactaaga actcgctgat gcaggaccgg      660

gatgccgcct cagcccgcgc ctggcctaaa atgcatacag tcaacggata cgtgaatcgg      720

tcactgcccg ggctcatcgg ttgtcacaga aagtccgtgt actggcacgt catcggcatg      780

ggcactacgc ctgaagtgca ctccatcttc ctggaagggc acaccttcct cgtgcgcaac      840

caccgccagg cctctctgga aatctccccg attacctttc tgaccgccca gactctgctc      900

atggacctgg ggcagttcct tctcttctgc cacatctcca gccatcagca cgacggaatg      960

gaggcctacg tgaaggtgga ctcatgcccg gaagaacctc agttgcggat gaagaacaac     1020

gaggaggccg aggactatga cgacgatttg actgactccg agatggacgt cgtgcggttc     1080

gatgacgaca acagccccag cttcatccag attcgcagcg tggccaagaa gcaccccaaa     1140

acctgggtgc actacatcgc ggccgaggaa gaagattggg actacgcccc gttggtgctg     1200

gcacccgatg accggtcgta caagtcccag tatctgaaca atggtccgca gcggattggc     1260

agaaagtaca agaaagtgcg gttcatggcg tacactgacg aaacgtttaa gacccgggag     1320

gccattcaac atgagagcgg cattctggga ccactgctgt acggagaggt cggcgatacc     1380

ctgctcatca tcttcaaaaa ccaggcctcc cggccttaca acatctaccc tcacggaatc     1440

accgacgtgc ggccactcta ctcgcggcgc ctgccgaagg gcgtcaagca cctgaaagac     1500

ttccctatcc tgccgggcga aatcttcaag tataagtgga ccgtcaccgt ggaggacggg     1560

cccaccaaga gcgatcctag gtgtctgact cggtactact ccagcttcgt gaacatggaa     1620

cgggacctgg catcgggact cattggaccg ctgctgatct gctacaaaga gtcggtggat     1680

caacgcggca accagatcat gtccgacaag cgcaacgtga tcctgttctc cgtg           1734


<210>  10
<211>  2583
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-62-CT

<400>  10
tttgatgaaa acagatcctg gtacctgacc gagaacatcc agaggttcct gcccaaccct       60

gctggggtgc agctggagga ccccgagttc caggccagca acatcatgca cagcatcaat      120

ggctacgtgt tcgacagcct gcagctgagc gtgtgcctgc acgaggtggc ctactggtac      180

atcctgagca tcggcgccca gaccgacttc ctgagcgtgt tcttctctgg ctacaccttc      240

aagcacaaga tggtgtatga ggacaccctg accctgttcc ccttcagcgg ggagactgtc      300

ttcatgagca tggagaaccc tggcctgtgg atcctgggct gccacaacag cgacttcagg      360

aacaggggca tgactgccct gctgaaagtc tccagctgtg acaagaacac cggggactac      420

tacgaggaca gctacgagga catcagcgcc tacctgctga gcaagaacaa tgccatcgag      480

cccaggagct tctctcagaa ccccccagtg ctgaagaggc accagaggga gatcaccagg      540

accaccctgc agtctgacca ggaggagatc gactatgatg acaccatcag cgtggagatg      600

aagaaggagg acttcgacat ctacgacgag gacgagaacc agagccccag gagcttccag      660

aagaagacca ggcactactt cattgctgct gtggagaggc tgtgggacta tggcatgtcc      720

agcagccccc atgtgctgag gaacagggcc cagtctggca gcgtgcccca gttcaagaaa      780

gtcgtgttcc aggagttcac cgacggcagc ttcacccagc ccctgtacag aggggagctg      840

aacgagcacc tgggcctgct gggcccctac atcagggccg aggtggagga caacatcatg      900

gtgaccttca ggaaccaggc cagcaggccc tacagcttct acagcagcct gatcagctac      960

gaggaggacc agaggcaggg ggctgagccc aggaagaact ttgtgaagcc caatgaaacc     1020

aagacctact tctggaaggt gcagcaccac atggccccca ccaaggacga gttcgactgc     1080

aaggcctggg cctacttctc tgacgtggac ctggagaagg acgtgcactc tggcctgatt     1140

ggccccctgc tggtgtgcca caccaacacc ctgaaccctg cccatggcag gcaggtgact     1200

gtgcaggagt tcgccctgtt cttcaccatc ttcgatgaaa ccaagagctg gtacttcact     1260

gagaacatgg agaggaactg cagggccccc tgcaacatcc agatggagga ccccaccttc     1320

aaggagaact acaggttcca tgccatcaat ggctacatca tggacaccct gcctggcctg     1380

gtcatggccc aggaccagag gatcaggtgg tatctgctga gcatgggcag caacgagaac     1440

atccacagca tccacttctc tggccacgtg ttcactgtga ggaagaagga ggagtacaag     1500

atggccctgt acaacctgta ccctggggtg ttcgaaaccg tggagatgct gcccagcaag     1560

gccggcatct ggagggtgga gtgcctgatt ggggagcacc tgcacgccgg catgagcacc     1620

ctgttcctgg tgtacagcaa caagtgccag acccccctgg gcatggcctc tggccacatc     1680

agggacttcc agatcactgc ctctggccag tacggccagt gggcccccaa gctggccagg     1740

ctgcactact ccggaagcat caatgcctgg agcaccaagg agcccttcag ctggatcaaa     1800

gtggacctgc tggcccccat gatcatccac ggcatcaaga cccagggggc caggcagaag     1860

ttctccagcc tgtacatcag ccagttcatc atcatgtaca gcctggacgg caagaagtgg     1920

cagacctaca ggggcaacag caccggcacc ctgatggtgt tcttcggcaa cgtggacagc     1980

agcggcatca agcacaacat cttcaacccc cccatcatcg ccagatacat caggctgcac     2040

cccacccact acagcatcag gagcaccctg aggatggagc tgatgggctg tgacctgaac     2100

agctgcagca tgcccctggg catggagagc aaggccatct ctgacgccca gatcactgcc     2160

tccagctact tcaccaacat gtttgccacc tggagcccca gcaaggccag gctgcacctg     2220

cagggcagga gcaatgcctg gaggccccag gtcaacaacc ccaaggagtg gctgcaggtg     2280

gacttccaga agaccatgaa ggtgactggg gtgaccaccc agggggtgaa gagcctgctg     2340

accagcatgt acgtgaagga gttcctgatc tccagcagcc aggacggcca ccagtggacc     2400

ctgttcttcc agaatggcaa ggtgaaggtg ttccagggca accaggacag cttcacccct     2460

gtggtcaaca gcctggaccc ccccctgctg accagatacc tgaggatcca cccccagagc     2520

tgggtgcacc agatcgccct gaggatggag gtgctgggct gtgaggccca ggacctgtac     2580

tga                                                                   2583


<210>  11
<211>  1734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-25-NT58

<400>  11
gccaccagga gatactacct gggcgccgtg gagctgagct gggactacat gcagtctgac       60

ctgggcgagc tgccagtgga cgccaggttc ccccccagag tgcccaagag cttccccttc      120

aacaccagcg tggtgtacaa gaagaccctg ttcgtggagt tcactgacca cctgttcaac      180

atcgccaagc ccaggccccc ctggatgggc ctgctgggcc ccaccatcca ggccgaggtg      240

tacgacaccg tggtcatcac cctgaagaac atggccagcc accccgtctc cctgcacgcc      300

gtgggggtga gctactggaa ggcctctgag ggcgccgagt acgacgacca gaccagccag      360

agggagaagg aggacgacaa ggtgttccct gggggcagcc acacctacgt gtggcaggtc      420

ctgaaggaga acggccccat ggcctctgac cccctgtgcc tgacctacag ctacctgagc      480

cacgtggacc tggtgaagga cctgaactct ggcctgattg gggccctgct ggtgtgcagg      540

gagggcagcc tggccaagga gaagacccag accctgcaca agttcatcct gctgttcgcc      600

gtgttcgacg agggcaagag ctggcactct gaaaccaaga acagcctgat gcaggacagg      660

gacgccgcct ctgccagggc ctggcccaag atgcacaccg tcaacggcta cgtcaacagg      720

agcctgcctg gcctgattgg ctgccacagg aagagcgtgt actggcatgt gatcggcatg      780

ggcaccaccc ctgaggtgca cagcatcttc ctggagggcc acaccttcct ggtcaggaac      840

cacaggcagg ccagcctgga gatcagcccc atcaccttcc tgaccgccca gaccctgctg      900

atggacctgg gccagttcct gctgttctgc cacatctcca gccaccagca cgacggcatg      960

gaggcctacg tgaaagtgga cagctgccct gaggagcccc agctgaggat gaagaacaac     1020

gaggaggccg aggactatga tgacgacctg accgacagcg agatggacgt ggtcaggttc     1080

gacgacgaca acagccccag cttcatccag atcaggagcg tggccaagaa gcaccccaag     1140

acctgggtgc actacatcgc tgctgaggag gaggactggg actatgcccc cctggtgctg     1200

gcccctgatg acaggagcta caagagccag tacctgaaca atggccccca gaggattggc     1260

aggaagtaca agaaagtcag gttcatggcc tacactgatg aaaccttcaa gaccagggag     1320

gccatccagc atgagtctgg catcctgggc cccctgctgt acggggaggt gggggacacc     1380

ctgctgatca tcttcaagaa ccaggccagc aggccctaca acatctaccc ccatggcatc     1440

accgacgtga ggcccctgta cagcaggagg ctgcctaagg gggtgaagca cctgaaagac     1500

ttccccatcc tgcctgggga gatcttcaag tacaagtgga ctgtgactgt ggaggacggc     1560

cccaccaaga gcgaccccag gtgcctgacc agatactaca gcagcttcgt caacatggag     1620

agggacctgg cctctggcct gattggcccc ctgctgatct gctacaagga gtctgtggac     1680

cagaggggca accagatcat gagcgacaag aggaacgtga tcctgttctc tgtc           1734


<210>  12
<211>  2583
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-25-CT

<400>  12
ttcgacgaga acaggagctg gtacctgact gaaaacatcc agcggttcct ccccaacccc       60

gcgggcgtgc agctggaaga tcctgagttt caggcatcaa acatcatgca ctccattaac      120

ggctacgtgt tcgattcgct gcagctgagc gtgtgtctgc acgaagtggc ctactggtac      180

atcctgtcca ttggtgccca gactgacttc ctgtccgtgt ttttctccgg ctacacgttc      240

aagcacaaga tggtgtacga ggacaccctg accctcttcc ctttttccgg cgaaactgtg      300

tttatgagca tggagaatcc cggcctgtgg atcttgggct gccacaacag cgacttccgt      360

aacagaggaa tgactgcgct gctcaaggtg tccagctgcg acaagaacac cggagactat      420

tatgaggact catacgagga catctccgcc tacctcctgt ccaagaataa cgccattgaa      480

cctcggagct tcagccagaa cccacccgtg cttaagagac atcaacggga gatcactagg      540

accaccctgc agtcagacca ggaggaaatc gactacgatg acaccatctc ggtcgagatg      600

aagaaggagg actttgacat ctacgacgaa gatgaaaacc agagcccgag gtcgttccaa      660

aagaaaaccc gccactactt tattgctgct gtcgagcggc tgtgggacta cggaatgtcg      720

tcctcgccgc acgtgctccg caaccgagcc cagagcggct cggtgccgca attcaagaag      780

gtcgtgttcc aggagttcac tgacgggagc ttcactcagc ctttgtaccg gggagaactc      840

aatgaacatc tcggcctcct cggaccttac atcagagcag aagtggaaga taacatcatg      900

gtcactttcc gtaaccaagc cagccgcccg tactcgttct actcctccct catttcttac      960

gaagaggacc agcggcaggg cgcagaaccg cgcaagaact tcgtgaagcc caacgaaacc     1020

aagacctact tctggaaagt gcagcatcat atggccccga ctaaggacga gtttgactgc     1080

aaagcctggg cctacttctc cgatgtggac ttggagaagg acgtccactc cggcctcatc     1140

ggtcccctgc tcgtgtgcca taccaatacc ctgaaccccg cacacggtcg ccaggtcacc     1200

gtgcaggagt tcgctctgtt cttcactatc ttcgacgaaa ctaagtcctg gtacttcacc     1260

gagaacatgg agaggaactg cagagccccc tgtaacatcc agatggagga cccgacgttc     1320

aaggaaaact accggttcca cgccattaac ggatacatca tggatacgct gccgggtctt     1380

gtgatggccc aggatcaacg gatcagatgg tacttattgt cgatgggcag caacgagaac     1440

atccactcta ttcacttctc cggtcatgtg ttcactgtgc ggaagaagga agagtacaag     1500

atggccctgt acaaccttta tcccggagtg ttcgaaactg tggaaatgct gccgtcgaag     1560

gccggcattt ggcgcgtgga gtgtttgatt ggagaacatc tccatgcggg gatgtcaacc     1620

ctgttcctgg tgtatagcaa caagtgccag actccgcttg ggatggcgtc aggacacatt     1680

agggatttcc agatcactgc gtccggccag tacggccaat gggcccctaa gctggcccgc     1740

ctgcattact ccggatccat taacgcctgg tcaaccaagg agccattctc ctggatcaag     1800

gtggaccttc tggcccccat gattatccac ggaattaaga cccagggggc ccggcagaag     1860

ttctcctcac tgtacatcag ccagttcata atcatgtact ccctggacgg aaagaagtgg     1920

caaacctaca gggggaacag caccggcaca ctgatggtct ttttcggaaa tgtggactcc     1980

tccgggatta agcataacat cttcaaccct ccgattatcg ctcggtacat tagacttcac     2040

cctacccact acagcattcg ctccaccctg cggatggaac tgatgggctg cgatctgaac     2100

tcgtgcagca tgccgttggg aatggagtcc aaagcaattt ccgacgcgca gatcaccgcc     2160

tcgtcctact ttaccaacat gttcgccacg tggtcaccgt ccaaggcccg gctgcacctc     2220

cagggaagat ccaacgcatg gcggccacag gtcaacaacc ctaaggagtg gctccaggtg     2280

gacttccaga aaaccatgaa ggtcaccgga gtcacaaccc agggagtgaa gtcgctgctg     2340

acttctatgt acgtcaagga gttcctgatc tccagcagcc aggacgggca ccagtggacc     2400

ctgttcttcc aaaatggaaa ggtcaaggtg tttcagggca atcaggattc attcaccccg     2460

gtggtgaact cccttgatcc acccctcctg acccgctacc ttcgcatcca cccacagtcc     2520

tgggtgcacc agatcgcgct gaggatggag gtcctgggat gcgaagccca ggacctgtac     2580

tga                                                                   2583


<210>  13
<211>  1734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-26-NT58

<400>  13
gccaccagga gatactacct gggcgccgtg gagctgagct gggactacat gcagtctgac       60

ctgggcgagc tgccagtgga cgccaggttc ccccccagag tgcccaagag cttccccttc      120

aacaccagcg tggtgtacaa gaagaccctg ttcgtggagt tcactgacca cctgttcaac      180

atcgccaagc ccaggccccc ctggatgggc ctgctgggcc ccaccatcca ggccgaggtg      240

tacgacaccg tggtcatcac cctgaagaac atggccagcc accccgtctc cctgcacgcc      300

gtgggggtga gctactggaa ggcctctgag ggcgccgagt acgacgacca gaccagccag      360

agggagaagg aggacgacaa ggtgttccct gggggcagcc acacctacgt gtggcaggtc      420

ctgaaggaga acggccccat ggcctctgac cccctgtgcc tgacctacag ctacctgagc      480

cacgtggacc tggtgaagga cctgaactct ggcctgattg gggccctgct ggtgtgcagg      540

gagggcagcc tggccaagga gaagacccag accctgcaca agttcatcct gctgttcgcc      600

gtgttcgacg agggcaagag ctggcactct gaaaccaaga acagcctgat gcaggacagg      660

gacgccgcct ctgccagggc ctggcccaag atgcacaccg tcaacggcta cgtcaacagg      720

agcctgcctg gcctgattgg ctgccacagg aagagcgtgt actggcatgt gatcggcatg      780

ggcaccaccc ctgaggtgca cagcatcttc ctggagggcc acaccttcct ggtcaggaac      840

cacaggcagg ccagcctgga gatcagcccc atcaccttcc tgaccgccca gaccctgctg      900

atggacctgg gccagttcct gctgttctgc cacatctcca gccaccagca cgacggcatg      960

gaggcctacg tgaaagtgga cagctgccct gaggagcccc agctgaggat gaagaacaac     1020

gaggaggccg aggactatga tgacgacctg accgacagcg agatggacgt ggtcaggttc     1080

gacgacgaca acagccccag cttcatccag atcaggagcg tggccaagaa gcaccccaag     1140

acctgggtgc actacatcgc tgctgaggag gaggactggg actatgcccc cctggtgctg     1200

gcccctgatg acaggagcta caagagccag tacctgaaca atggccccca gaggattggc     1260

aggaagtaca agaaagtcag gttcatggcc tacactgatg aaaccttcaa gaccagggag     1320

gccatccagc atgagtctgg catcctgggc cccctgctgt acggggaggt gggggacacc     1380

ctgctgatca tcttcaagaa ccaggccagc aggccctaca acatctaccc ccatggcatc     1440

accgacgtga ggcccctgta cagcaggagg ctgcctaagg gggtgaagca cctgaaagac     1500

ttccccatcc tgcctgggga gatcttcaag tacaagtgga ctgtgactgt ggaggacggc     1560

cccaccaaga gcgaccccag gtgcctgacc agatactaca gcagcttcgt caacatggag     1620

agggacctgg cctctggcct gattggcccc ctgctgatct gctacaagga gtctgtggac     1680

cagaggggca accagatcat gagcgacaag aggaacgtga tcctgttctc tgtc           1734


<210>  14
<211>  2583
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-26-CT

<400>  14
ttcgacgaga acaggagctg gtacctcact gaaaacatcc agaggttcct cccaaacccc       60

gcaggagtgc aactggagga ccctgagttt caggcctcga atatcatgca ctcgattaac      120

ggttacgtgt tcgactcgct gcagctgagc gtgtgcctcc atgaagtcgc ttactggtac      180

attctgtcca tcggcgccca gactgacttc ctgagcgtgt tcttttccgg ttacaccttt      240

aagcacaaga tggtgtacga agataccctg accctgttcc ctttctccgg cgaaacggtg      300

ttcatgtcga tggagaaccc gggtctgtgg attctgggat gccacaacag cgactttcgg      360

aaccgcggaa tgactgccct gctgaaggtg tcctcatgcg acaagaacac cggagactac      420

tacgaggact cctacgagga tatctcagcc tacctcctgt ccaagaacaa cgcgatcgag      480

ccgcgcagct tcagccagaa cccgcctgtg ctgaagaggc accagcgaga aattacccgg      540

accaccctcc aatcggatca ggaggaaatc gactacgacg acaccatctc ggtggaaatg      600

aagaaggaag atttcgatat ctacgacgag gacgaaaatc agtcccctcg ctcattccaa      660

aagaaaacta gacactactt tatcgccgcg gtggaaagac tgtgggacta tggaatgtca      720

tccagccctc acgtccttcg gaaccgggcc cagagcggat cggtgcctca gttcaagaaa      780

gtggtgttcc aggagttcac cgacggcagc ttcacccagc cgctgtaccg gggagaactg      840

aacgaacacc tgggcctgct cggtccctac atccgcgcgg aagtggagga taacatcatg      900

gtgaccttcc gtaaccaagc atccagacct tactccttct attcctccct gatctcatac      960

gaggaggacc agcgccaagg cgccgagccc cgcaagaact tcgtcaagcc caacgagact     1020

aagacctact tctggaaggt ccaacaccat atggccccga ccaaggatga gtttgactgc     1080

aaggcctggg cctacttctc cgacgtggac cttgagaagg atgtccattc cggcctgatc     1140

gggccgctgc tcgtgtgtca caccaacacc ctgaacccag cgcatggacg ccaggtcacc     1200

gtccaggagt ttgctctgtt cttcaccatt tttgacgaaa ctaagtcctg gtacttcacc     1260

gagaatatgg agcgaaactg tagagcgccc tgcaatatcc agatggaaga tccgactttc     1320

aaggagaact atagattcca cgccatcaac gggtacatca tggatactct gccggggctg     1380

gtcatggccc aggatcagag gattcggtgg tacttgctgt caatgggatc gaacgaaaac     1440

attcactcca ttcacttctc cggtcacgtg ttcactgtgc gcaagaagga ggagtacaag     1500

atggcgctgt acaatctgta ccccggggtg ttcgaaactg tggagatgct gccgtccaag     1560

gccggcatct ggagagtgga gtgcctgatc ggagagcacc tccacgcggg gatgtccacc     1620

ctcttcctgg tgtactcgaa taagtgccag accccgctgg gcatggcctc gggccacatc     1680

agagacttcc agatcacagc aagcggacaa tacggccaat gggcgccgaa gctggcccgc     1740

ttgcactact ccggatcgat caacgcatgg tccaccaagg aaccgttctc gtggattaag     1800

gtggacctcc tggcccctat gattatccac ggaattaaga cccagggcgc caggcagaag     1860

ttctcctccc tgtacatctc gcaattcatc atcatgtaca gcctggacgg gaagaagtgg     1920

cagacttaca ggggaaactc caccggcacc ctgatggtct ttttcggcaa cgtggattcc     1980

tccggcatta agcacaacat cttcaaccca ccgatcatag ccagatatat taggctccac     2040

cccactcact actcaatccg ctcaactctt cggatggaac tcatggggtg cgacctgaac     2100

tcctgctcca tgccgttggg gatggaatca aaggctatta gcgacgccca gatcaccgcg     2160

agctcctact tcactaacat gttcgccacc tggagcccct ccaaggccag gctgcacttg     2220

cagggacggt caaatgcctg gcggccgcaa gtgaacaatc cgaaggaatg gcttcaagtg     2280

gatttccaaa agaccatgaa agtgaccgga gtcaccaccc agggagtgaa gtcccttctg     2340

acctcgatgt atgtgaagga gttcctgatt agcagcagcc aggacgggca ccagtggacc     2400

ctgttcttcc aaaacggaaa ggtcaaggtg ttccagggga accaggactc gttcacaccc     2460

gtggtgaact ccctggaccc cccactgctg acgcggtact tgaggattca tcctcagtcc     2520

tgggtccatc agattgcatt gcgaatggaa gtcctgggct gcgaggccca ggacctgtac     2580

tga                                                                   2583


<210>  15
<211>  2332
<212>  PRT
<213>  Homo sapiens

<400>  15

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg 
            740                 745                 750         


Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys 
        755                 760                 765             


Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn 
    770                 775                 780                 


Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro 
785                 790                 795                 800 


His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe 
                805                 810                 815     


Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser 
            820                 825                 830         


Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val 
        835                 840                 845             


Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly 
    850                 855                 860                 


Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser 
865                 870                 875                 880 


Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala 
                885                 890                 895     


Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His 
            900                 905                 910         


Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro 
        915                 920                 925             


Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp 
    930                 935                 940                 


Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp 
945                 950                 955                 960 


Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys 
                965                 970                 975     


Arg Ala His Gly Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys 
            980                 985                 990         


Val Ser Ile Ser Leu Leu Lys Thr  Asn Lys Thr Ser Asn  Asn Ser Ala 
        995                 1000                 1005             


Thr Asn  Arg Lys Thr His Ile  Asp Gly Pro Ser Leu  Leu Ile Glu 
    1010                 1015                 1020             


Asn Ser  Pro Ser Val Trp Gln  Asn Ile Leu Glu Ser  Asp Thr Glu 
    1025                 1030                 1035             


Phe Lys  Lys Val Thr Pro Leu  Ile His Asp Arg Met  Leu Met Asp 
    1040                 1045                 1050             


Lys Asn  Ala Thr Ala Leu Arg  Leu Asn His Met Ser  Asn Lys Thr 
    1055                 1060                 1065             


Thr Ser  Ser Lys Asn Met Glu  Met Val Gln Gln Lys  Lys Glu Gly 
    1070                 1075                 1080             


Pro Ile  Pro Pro Asp Ala Gln  Asn Pro Asp Met Ser  Phe Phe Lys 
    1085                 1090                 1095             


Met Leu  Phe Leu Pro Glu Ser  Ala Arg Trp Ile Gln  Arg Thr His 
    1100                 1105                 1110             


Gly Lys  Asn Ser Leu Asn Ser  Gly Gln Gly Pro Ser  Pro Lys Gln 
    1115                 1120                 1125             


Leu Val  Ser Leu Gly Pro Glu  Lys Ser Val Glu Gly  Gln Asn Phe 
    1130                 1135                 1140             


Leu Ser  Glu Lys Asn Lys Val  Val Val Gly Lys Gly  Glu Phe Thr 
    1145                 1150                 1155             


Lys Asp  Val Gly Leu Lys Glu  Met Val Phe Pro Ser  Ser Arg Asn 
    1160                 1165                 1170             


Leu Phe  Leu Thr Asn Leu Asp  Asn Leu His Glu Asn  Asn Thr His 
    1175                 1180                 1185             


Asn Gln  Glu Lys Lys Ile Gln  Glu Glu Ile Glu Lys  Lys Glu Thr 
    1190                 1195                 1200             


Leu Ile  Gln Glu Asn Val Val  Leu Pro Gln Ile His  Thr Val Thr 
    1205                 1210                 1215             


Gly Thr  Lys Asn Phe Met Lys  Asn Leu Phe Leu Leu  Ser Thr Arg 
    1220                 1225                 1230             


Gln Asn  Val Glu Gly Ser Tyr  Asp Gly Ala Tyr Ala  Pro Val Leu 
    1235                 1240                 1245             


Gln Asp  Phe Arg Ser Leu Asn  Asp Ser Thr Asn Arg  Thr Lys Lys 
    1250                 1255                 1260             


His Thr  Ala His Phe Ser Lys  Lys Gly Glu Glu Glu  Asn Leu Glu 
    1265                 1270                 1275             


Gly Leu  Gly Asn Gln Thr Lys  Gln Ile Val Glu Lys  Tyr Ala Cys 
    1280                 1285                 1290             


Thr Thr  Arg Ile Ser Pro Asn  Thr Ser Gln Gln Asn  Phe Val Thr 
    1295                 1300                 1305             


Gln Arg  Ser Lys Arg Ala Leu  Lys Gln Phe Arg Leu  Pro Leu Glu 
    1310                 1315                 1320             


Glu Thr  Glu Leu Glu Lys Arg  Ile Ile Val Asp Asp  Thr Ser Thr 
    1325                 1330                 1335             


Gln Trp  Ser Lys Asn Met Lys  His Leu Thr Pro Ser  Thr Leu Thr 
    1340                 1345                 1350             


Gln Ile  Asp Tyr Asn Glu Lys  Glu Lys Gly Ala Ile  Thr Gln Ser 
    1355                 1360                 1365             


Pro Leu  Ser Asp Cys Leu Thr  Arg Ser His Ser Ile  Pro Gln Ala 
    1370                 1375                 1380             


Asn Arg  Ser Pro Leu Pro Ile  Ala Lys Val Ser Ser  Phe Pro Ser 
    1385                 1390                 1395             


Ile Arg  Pro Ile Tyr Leu Thr  Arg Val Leu Phe Gln  Asp Asn Ser 
    1400                 1405                 1410             


Ser His  Leu Pro Ala Ala Ser  Tyr Arg Lys Lys Asp  Ser Gly Val 
    1415                 1420                 1425             


Gln Glu  Ser Ser His Phe Leu  Gln Gly Ala Lys Lys  Asn Asn Leu 
    1430                 1435                 1440             


Ser Leu  Ala Ile Leu Thr Leu  Glu Met Thr Gly Asp  Gln Arg Glu 
    1445                 1450                 1455             


Val Gly  Ser Leu Gly Thr Ser  Ala Thr Asn Ser Val  Thr Tyr Lys 
    1460                 1465                 1470             


Lys Val  Glu Asn Thr Val Leu  Pro Lys Pro Asp Leu  Pro Lys Thr 
    1475                 1480                 1485             


Ser Gly  Lys Val Glu Leu Leu  Pro Lys Val His Ile  Tyr Gln Lys 
    1490                 1495                 1500             


Asp Leu  Phe Pro Thr Glu Thr  Ser Asn Gly Ser Pro  Gly His Leu 
    1505                 1510                 1515             


Asp Leu  Val Glu Gly Ser Leu  Leu Gln Gly Thr Glu  Gly Ala Ile 
    1520                 1525                 1530             


Lys Trp  Asn Glu Ala Asn Arg  Pro Gly Lys Val Pro  Phe Leu Arg 
    1535                 1540                 1545             


Val Ala  Thr Glu Ser Ser Ala  Lys Thr Pro Ser Lys  Leu Leu Asp 
    1550                 1555                 1560             


Pro Leu  Ala Trp Asp Asn His  Tyr Gly Thr Gln Ile  Pro Lys Glu 
    1565                 1570                 1575             


Glu Trp  Lys Ser Gln Glu Lys  Ser Pro Glu Lys Thr  Ala Phe Lys 
    1580                 1585                 1590             


Lys Lys  Asp Thr Ile Leu Ser  Leu Asn Ala Cys Glu  Ser Asn His 
    1595                 1600                 1605             


Ala Ile  Ala Ala Ile Asn Glu  Gly Gln Asn Lys Pro  Glu Ile Glu 
    1610                 1615                 1620             


Val Thr  Trp Ala Lys Gln Gly  Arg Thr Glu Arg Leu  Cys Ser Gln 
    1625                 1630                 1635             


Asn Pro  Pro Val Leu Lys Arg  His Gln Arg Glu Ile  Thr Arg Thr 
    1640                 1645                 1650             


Thr Leu  Gln Ser Asp Gln Glu  Glu Ile Asp Tyr Asp  Asp Thr Ile 
    1655                 1660                 1665             


Ser Val  Glu Met Lys Lys Glu  Asp Phe Asp Ile Tyr  Asp Glu Asp 
    1670                 1675                 1680             


Glu Asn  Gln Ser Pro Arg Ser  Phe Gln Lys Lys Thr  Arg His Tyr 
    1685                 1690                 1695             


Phe Ile  Ala Ala Val Glu Arg  Leu Trp Asp Tyr Gly  Met Ser Ser 
    1700                 1705                 1710             


Ser Pro  His Val Leu Arg Asn  Arg Ala Gln Ser Gly  Ser Val Pro 
    1715                 1720                 1725             


Gln Phe  Lys Lys Val Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe 
    1730                 1735                 1740             


Thr Gln  Pro Leu Tyr Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu 
    1745                 1750                 1755             


Leu Gly  Pro Tyr Ile Arg Ala  Glu Val Glu Asp Asn  Ile Met Val 
    1760                 1765                 1770             


Thr Phe  Arg Asn Gln Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser 
    1775                 1780                 1785             


Leu Ile  Ser Tyr Glu Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg 
    1790                 1795                 1800             


Lys Asn  Phe Val Lys Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys 
    1805                 1810                 1815             


Val Gln  His His Met Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys 
    1820                 1825                 1830             


Ala Trp  Ala Tyr Phe Ser Asp  Val Asp Leu Glu Lys  Asp Val His 
    1835                 1840                 1845             


Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys His Thr  Asn Thr Leu 
    1850                 1855                 1860             


Asn Pro  Ala His Gly Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu 
    1865                 1870                 1875             


Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu 
    1880                 1885                 1890             


Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu 
    1895                 1900                 1905             


Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly 
    1910                 1915                 1920             


Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln 
    1925                 1930                 1935             


Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile 
    1940                 1945                 1950             


His Ser  Ile His Phe Ser Gly  His Val Phe Thr Val  Arg Lys Lys 
    1955                 1960                 1965             


Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe 
    1970                 1975                 1980             


Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val 
    1985                 1990                 1995             


Glu Cys  Leu Ile Gly Glu His  Leu His Ala Gly Met  Ser Thr Leu 
    2000                 2005                 2010             


Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala 
    2015                 2020                 2025             


Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr 
    2030                 2035                 2040             


Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser 
    2045                 2050                 2055             


Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val 
    2060                 2065                 2070             


Asp Leu  Leu Ala Pro Met Ile  Ile His Gly Ile Lys  Thr Gln Gly 
    2075                 2080                 2085             


Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile 
    2090                 2095                 2100             


Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn 
    2105                 2110                 2115             


Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly Asn Val  Asp Ser Ser 
    2120                 2125                 2130             


Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr 
    2135                 2140                 2145             


Ile Arg  Leu His Pro Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg 
    2150                 2155                 2160             


Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu 
    2165                 2170                 2175             


Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser 
    2180                 2185                 2190             


Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala 
    2195                 2200                 2205             


Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val 
    2210                 2215                 2220             


Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met 
    2225                 2230                 2235             


Lys Val  Thr Gly Val Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr 
    2240                 2245                 2250             


Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly 
    2255                 2260                 2265             


His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe 
    2270                 2275                 2280             


Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp 
    2285                 2290                 2295             


Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp 
    2300                 2305                 2310             


Val His  Gln Ile Ala Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala 
    2315                 2320                 2325             


Gln Asp  Leu Tyr 
    2330         


<210>  16
<211>  4371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BDD-FVIII (non-optimized; "parental"), Nucleotide Sequence

<400>  16
atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc       60

accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc      120

ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac      180

acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc      240

gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat      300

gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt      360

ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg      420

gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg      480

aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat      540

gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa      600

gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta      660

tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat      720

gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct      780

ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc      840

accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat      900

cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg      960

gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa     1020

gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa     1080

gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat     1140

gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact     1200

tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc     1260

cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg     1320

aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct     1380

attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg     1440

ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact     1500

gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt     1560

ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca     1620

actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga     1680

gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa     1740

agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag     1800

aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg     1860

cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt     1920

tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc     1980

attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa     2040

atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg     2100

atggaaaacc caggtctatg gattctgggg tgccacaact cagactttcg gaacagaggc     2160

atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac     2220

agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc     2280

ttctctcaaa acccaccagt cttgaaacgc catcaacggg aaataactcg tactactctt     2340

cagtcagatc aagaggaaat tgactatgat gataccatat cagttgaaat gaagaaggaa     2400

gattttgaca tttatgatga ggatgaaaat cagagccccc gcagctttca aaagaaaaca     2460

cgacactatt ttattgctgc agtggagagg ctctgggatt atgggatgag tagctcccca     2520

catgttctaa gaaacagggc tcagagtggc agtgtccctc agttcaagaa agttgttttc     2580

caggaattta ctgatggctc ctttactcag cccttatacc gtggagaact aaatgaacat     2640

ttgggactcc tggggccata tataagagca gaagttgaag ataatatcat ggtaactttc     2700

agaaatcagg cctctcgtcc ctattccttc tattctagcc ttatttctta tgaggaagat     2760

cagaggcaag gagcagaacc tagaaaaaac tttgtcaagc ctaatgaaac caaaacttac     2820

ttttggaaag tgcaacatca tatggcaccc actaaagatg agtttgactg caaagcctgg     2880

gcttatttct ctgatgttga cctggaaaaa gatgtgcact caggcctgat tggacccctt     2940

ctggtctgcc acactaacac actgaaccct gctcatggga gacaagtgac agtacaggaa     3000

tttgctctgt ttttcaccat ctttgatgag accaaaagct ggtacttcac tgaaaatatg     3060

gaaagaaact gcagggctcc ctgcaatatc cagatggaag atcccacttt taaagagaat     3120

tatcgcttcc atgcaatcaa tggctacata atggatacac tacctggctt agtaatggct     3180

caggatcaaa ggattcgatg gtatctgctc agcatgggca gcaatgaaaa catccattct     3240

attcatttca gtggacatgt gttcactgta cgaaaaaaag aggagtataa aatggcactg     3300

tacaatctct atccaggtgt ttttgagaca gtggaaatgt taccatccaa agctggaatt     3360

tggcgggtgg aatgccttat tggcgagcat ctacatgctg ggatgagcac actttttctg     3420

gtgtacagca ataagtgtca gactcccctg ggaatggctt ctggacacat tagagatttt     3480

cagattacag cttcaggaca atatggacag tgggccccaa agctggccag acttcattat     3540

tccggatcaa tcaatgcctg gagcaccaag gagccctttt cttggatcaa ggtggatctg     3600

ttggcaccaa tgattattca cggcatcaag acccagggtg cccgtcagaa gttctccagc     3660

ctctacatct ctcagtttat catcatgtat agtcttgatg ggaagaagtg gcagacttat     3720

cgaggaaatt ccactggaac cttaatggtc ttctttggca atgtggattc atctgggata     3780

aaacacaata tttttaaccc tccaattatt gctcgataca tccgtttgca cccaactcat     3840

tatagcattc gcagcactct tcgcatggag ttgatgggct gtgatttaaa tagttgcagc     3900

atgccattgg gaatggagag taaagcaata tcagatgcac agattactgc ttcatcctac     3960

tttaccaata tgtttgccac ctggtctcct tcaaaagctc gacttcacct ccaagggagg     4020

agtaatgcct ggagacctca ggtgaataat ccaaaagagt ggctgcaagt ggacttccag     4080

aagacaatga aagtcacagg agtaactact cagggagtaa aatctctgct taccagcatg     4140

tatgtgaagg agttcctcat ctccagcagt caagatggcc atcagtggac tctctttttt     4200

cagaatggca aagtaaaggt ttttcaggga aatcaagact ccttcacacc tgtggtgaac     4260

tctctagacc caccgttact gactcgctac cttcgaattc acccccagag ttgggtgcac     4320

cagattgccc tgaggatgga ggttctgggc tgcgaggcac aggacctcta c              4371


<210>  17
<211>  1438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BDD-FVIII (non-optimized; "parental"), Amino Acid Sequence

<400>  17

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser 
            820                 825                 830         


Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 
        835                 840                 845             


Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 
    850                 855                 860                 


Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr 
865                 870                 875                 880 


Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 
                885                 890                 895     


Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 
            900                 905                 910         


Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 
        915                 920                 925             


Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 
    930                 935                 940                 


Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro 
945                 950                 955                 960 


Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln 
                965                 970                 975     


Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr 
            980                 985                 990         


Lys Ser Trp Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
        995                 1000                 1005             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1010                 1015                 1020             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1025                 1030                 1035             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1040                 1045                 1050             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1055                 1060                 1065             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1070                 1075                 1080             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1085                 1090                 1095             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1100                 1105                 1110             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1115                 1120                 1125             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1130                 1135                 1140             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1145                 1150                 1155             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1160                 1165                 1170             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1175                 1180                 1185             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1190                 1195                 1200             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1205                 1210                 1215             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1220                 1225                 1230             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1235                 1240                 1245             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1250                 1255                 1260             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1265                 1270                 1275             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1280                 1285                 1290             


Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1295                 1300                 1305             


Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 
    1310                 1315                 1320             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    1325                 1330                 1335             


Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 
    1340                 1345                 1350             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    1355                 1360                 1365             


Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 
    1370                 1375                 1380             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    1385                 1390                 1395             


Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1400                 1405                 1410             


Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 
    1415                 1420                 1425             


Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr 
    1430                 1435             


<210>  18
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN nucleotide sequence

<400>  18
ggcgcgccaa catcagagag cgccacccct gaaagtggtc ccgggagcga gccagccaca       60

tctgggtcgg aaacgccagg cacaagtgag tctgcaactc ccgagtccgg acctggctcc      120

gagcctgcca ctagcggctc cgagactccg ggaacttccg agagcgctac accagaaagc      180

ggacccggaa ccagtaccga acctagcgag ggctctgctc cgggcagccc agccggctct      240

cctacatcca cggaggaggg cacttccgaa tccgccaccc cggagtcagg gccaggatct      300

gaacccgcta cctcaggcag tgagacgcca ggaacgagcg agtccgctac accggagagt      360

gggccaggga gccctgctgg atctcctacg tccactgagg aagggtcacc agcgggctcg      420

cccaccagca ctgaagaagg tgcctcgagc                                       450


<210>  19
<211>  4824
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-52-XTEN

<400>  19
atgcaaatcg aactgagcac ctgtttcttc ctctgcctgc tgagattctg tttctccgcg       60

acccgccgat actacctggg agcagtggag ctctcctggg attacatgca gagcgacctt      120

ggggagctgc ccgtggatgc caggttccct ccccgggtgc caaagtcgtt tccgttcaac      180

acctccgtgg tgtacaagaa aactctgttc gtggagttca ccgaccacct gttcaatatc      240

gccaagccca gacctccctg gatggggctg ttgggaccta ccatccaagc ggaggtgtac      300

gacactgtgg tcatcactct gaagaacatg gcctcgcatc ccgtgtccct gcacgccgtg      360

ggagtgtctt actggaaagc gtccgagggg gccgaatacg acgaccagac ctcgcagaga      420

gaaaaggaag atgacaaggt gttcccagga ggatcgcaca cctacgtgtg gcaagtgttg      480

aaggagaacg gcccaatggc ctccgacccg ctgtgcctga cctactcgta cctgtcccac      540

gtggacctcg tgaaggacct caactcggga ctgattggag ccctgctggt ctgcagggaa      600

ggctcactgg cgaaagaaaa gactcagacc ttgcacaagt tcattctgct gttcgctgtg      660

ttcgacgagg ggaagtcgtg gcacagcgag actaagaact ccctgatgca agatagagat      720

gccgcctccg cccgggcctg gcctaagatg cacaccgtga acggttacgt gaaccgctcc      780

ctccctggcc tgattggatg ccaccggaag tccgtgtact ggcacgtgat cgggatgggg      840

accacccccg aggtgcacag catcttcctg gaaggtcaca catttctcgt gcgcaaccac      900

cggcaggcct ccctggaaat cagccccatt accttcctca ctgcccagac tctgctgatg      960

gacctgggac agttcctgct gttctgccat atctcctccc accaacatga cggaatggag     1020

gcatacgtga aggtcgattc ctgccctgag gaaccccagc tccgcatgaa gaacaatgag     1080

gaagccgagg actacgacga cgacctgacg gatagcgaga tggatgtggt ccggttcgat     1140

gacgataaca gcccttcctt catccaaatt cgctcggtgg caaagaagca ccccaagacc     1200

tgggtgcatt acattgcggc ggaagaagag gactgggatt atgccccgct tgtcctcgct     1260

cctgacgacc ggagctacaa gagccagtac ctgaacaacg gtccacagag gatcggtaga     1320

aagtacaaga aggtccgctt catggcctat accgacgaaa ccttcaaaac tagagaggcc     1380

atccaacacg aatccggcat cctgggcccg ctcttgtacg gagaagtcgg cgacaccctt     1440

ctcattatct tcaagaacca ggcttcccgg ccgtacaaca tctatccgca tgggatcact     1500

gacgtgcgcc cactgtactc gcggcgcctg cccaagggtg tcaaacacct gaaggatttt     1560

ccgatccttc cgggagaaat cttcaagtac aagtggaccg tgaccgtgga agatggccca     1620

actaagtctg accctagatg cctcacccgc tactactcat ccttcgtcaa catggagcgc     1680

gacctggcca gcggactgat cggcccgctg ctgatttgct acaaggaatc agtggaccaa     1740

cggggaaacc agatcatgtc ggataagagg aacgtcatcc tcttctccgt gtttgacgaa     1800

aaccggtcgt ggtacctgac cgagaacatc cagaggttcc tgcccaaccc tgctggggtg     1860

cagctggagg accccgagtt ccaggccagc aacatcatgc acagcatcaa tggctacgtg     1920

ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc     1980

atcggcgccc agaccgactt cctgagcgtg ttcttctctg gctacacctt caagcacaag     2040

atggtgtatg aggacaccct gaccctgttc cccttcagcg gggagactgt cttcatgagc     2100

atggagaacc ctggcctgtg gatcctgggc tgccacaaca gcgacttcag gaacaggggc     2160

atgactgccc tgctgaaagt ctccagctgt gacaagaaca ccggggacta ctacgaggac     2220

agctacgagg acatcagcgc ctacctgctg agcaagaaca atgccatcga gcccaggagc     2280

ttctctcaga acggcgcgcc aacatcagag agcgccaccc ctgaaagtgg tcccgggagc     2340

gagccagcca catctgggtc ggaaacgcca ggcacaagtg agtctgcaac tcccgagtcc     2400

ggacctggct ccgagcctgc cactagcggc tccgagactc cgggaacttc cgagagcgct     2460

acaccagaaa gcggacccgg aaccagtacc gaacctagcg agggctctgc tccgggcagc     2520

ccagccggct ctcctacatc cacggaggag ggcacttccg aatccgccac cccggagtca     2580

gggccaggat ctgaacccgc tacctcaggc agtgagacgc caggaacgag cgagtccgct     2640

acaccggaga gtgggccagg gagccctgct ggatctccta cgtccactga ggaagggtca     2700

ccagcgggct cgcccaccag cactgaagaa ggtgcctcga gccccccagt gctgaagagg     2760

caccagaggg agatcaccag gaccaccctg cagtctgacc aggaggagat cgactatgat     2820

gacaccatca gcgtggagat gaagaaggag gacttcgaca tctacgacga ggacgagaac     2880

cagagcccca ggagcttcca gaagaagacc aggcactact tcattgctgc tgtggagagg     2940

ctgtgggact atggcatgtc cagcagcccc catgtgctga ggaacagggc ccagtctggc     3000

agcgtgcccc agttcaagaa agtcgtgttc caggagttca ccgacggcag cttcacccag     3060

cccctgtaca gaggggagct gaacgagcac ctgggcctgc tgggccccta catcagggcc     3120

gaggtggagg acaacatcat ggtgaccttc aggaaccagg ccagcaggcc ctacagcttc     3180

tacagcagcc tgatcagcta cgaggaggac cagaggcagg gggctgagcc caggaagaac     3240

tttgtgaagc ccaatgaaac caagacctac ttctggaagg tgcagcacca catggccccc     3300

accaaggacg agttcgactg caaggcctgg gcctacttct ctgacgtgga cctggagaag     3360

gacgtgcact ctggcctgat tggccccctg ctggtgtgcc acaccaacac cctgaaccct     3420

gcccatggca ggcaggtgac tgtgcaggag ttcgccctgt tcttcaccat cttcgatgaa     3480

accaagagct ggtacttcac tgagaacatg gagaggaact gcagggcccc ctgcaacatc     3540

cagatggagg accccacctt caaggagaac tacaggttcc atgccatcaa tggctacatc     3600

atggacaccc tgcctggcct ggtcatggcc caggaccaga ggatcaggtg gtatctgctg     3660

agcatgggca gcaacgagaa catccacagc atccacttct ctggccacgt gttcactgtg     3720

aggaagaagg aggagtacaa gatggccctg tacaacctgt accctggggt gttcgaaacc     3780

gtggagatgc tgcccagcaa ggccggcatc tggagggtgg agtgcctgat tggggagcac     3840

ctgcacgccg gcatgagcac cctgttcctg gtgtacagca acaagtgcca gacccccctg     3900

ggcatggcct ctggccacat cagggacttc cagatcactg cctctggcca gtacggccag     3960

tgggccccca agctggccag gctgcactac tccggaagca tcaatgcctg gagcaccaag     4020

gagcccttca gctggatcaa agtggacctg ctggccccca tgatcatcca cggcatcaag     4080

acccaggggg ccaggcagaa gttctccagc ctgtacatca gccagttcat catcatgtac     4140

agcctggacg gcaagaagtg gcagacctac aggggcaaca gcaccggcac cctgatggtg     4200

ttcttcggca acgtggacag cagcggcatc aagcacaaca tcttcaaccc ccccatcatc     4260

gccagataca tcaggctgca ccccacccac tacagcatca ggagcaccct gaggatggag     4320

ctgatgggct gtgacctgaa cagctgcagc atgcccctgg gcatggagag caaggccatc     4380

tctgacgccc agatcactgc ctccagctac ttcaccaaca tgtttgccac ctggagcccc     4440

agcaaggcca ggctgcacct gcagggcagg agcaatgcct ggaggcccca ggtcaacaac     4500

cccaaggagt ggctgcaggt ggacttccag aagaccatga aggtgactgg ggtgaccacc     4560

cagggggtga agagcctgct gaccagcatg tacgtgaagg agttcctgat ctccagcagc     4620

caggacggcc accagtggac cctgttcttc cagaatggca aggtgaaggt gttccagggc     4680

aaccaggaca gcttcacccc tgtggtcaac agcctggacc cccccctgct gaccagatac     4740

ctgaggatcc acccccagag ctgggtgcac cagatcgccc tgaggatgga ggtgctgggc     4800

tgtgaggccc aggacctgta ctga                                            4824


<210>  20
<211>  4824
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-1-XTEN

<400>  20
atgcagattg agctgtctac ttgctttttc ctgtgcctgc tgaggttttg cttttccgct       60

acacgaaggt attatctggg ggctgtggaa ctgtcttggg attacatgca gagtgacctg      120

ggagagctgc cagtggacgc aaggtttccc cctagagtcc ctaagtcatt ccccttcaac      180

actagcgtgg tctacaagaa aacactgttc gtggagttta ctgatcacct gttcaacatc      240

gcaaagccta ggccaccctg gatgggactg ctggggccaa caatccaggc cgaggtgtac      300

gacaccgtgg tcattacact taagaacatg gcctcacacc ccgtgagcct gcatgctgtg      360

ggcgtcagct actggaaggc ttccgaagga gcagagtatg acgatcagac ttcccagaga      420

gaaaaagagg acgataaggt gtttcctggc ggatctcata cctacgtgtg gcaggtcctg      480

aaagagaatg gccctatggc ctccgaccct ctgtgcctga cctactctta tctgagtcac      540

gtggacctgg tcaaggatct gaacagcggc ctgatcggag ccctgctggt gtgcagggaa      600

ggaagcctgg ctaaggagaa aacccagaca ctgcataagt tcattctgct gttcgccgtg      660

tttgacgaag ggaaatcatg gcacagcgag acaaagaata gtctgatgca ggacagggat      720

gccgcttcag ccagagcttg gcccaaaatg cacactgtga acggctacgt caatcgctca      780

ctgcctgggc tgatcggctg ccaccgaaag agcgtgtatt ggcatgtcat cgggatgggc      840

accacacctg aagtgcactc cattttcctg gagggacata cctttctggt ccgcaaccac      900

cgacaggctt ccctggagat ctctccaatt accttcctga cagcacagac tctgctgatg      960

gacctggggc agttcctgct gttttgccac atcagctccc accagcatga tggcatggag     1020

gcttacgtga aagtggactc ttgtcccgag gaacctcagc tgcggatgaa gaacaatgag     1080

gaagcagaag actatgacga tgacctgacc gactccgaga tggatgtggt ccgattcgat     1140

gacgataaca gcccctcctt tatccagatt agatctgtgg ccaagaaaca ccctaagaca     1200

tgggtccatt acatcgcagc cgaggaagag gactgggatt atgcaccact ggtgctggca     1260

ccagacgatc gctcctacaa atctcagtat ctgaacaatg ggccacagag gattggcaga     1320

aagtacaaga aagtgcggtt catggcatat accgatgaga ccttcaagac tcgcgaagcc     1380

atccagcacg agagcggcat cctgggacca ctgctgtacg gagaagtggg agacaccctg     1440

ctgatcattt tcaagaacca ggccagccgg ccttacaata tctatccaca tgggattaca     1500

gatgtgcgcc ctctgtacag caggagactg ccaaagggcg tcaaacacct gaaggacttc     1560

ccaatcctgc ccggagaaat cttcaagtac aagtggactg tcaccgtcga ggatggcccc     1620

actaagagcg accctcggtg cctgacccgc tactattcta gtttcgtgaa tatggaaaga     1680

gatctggcaa gcggactgat cggaccactg ctgatttgtt acaaagagag cgtggatcag     1740

agaggcaacc agatcatgtc cgacaagcgg aatgtgattc tgttcagtgt ctttgacgaa     1800

aacaggtcat ggtacctgac cgagaacatc cagagattcc tgcctaatcc agctggggtg     1860

cagctggaag atcctgagtt tcaggcatct aacatcatgc atagtattaa tggctacgtg     1920

ttcgacagtt tgcagctgag cgtgtgcctg cacgaggtcg cttactggta tatcctgagc     1980

attggggcac agacagattt cctgagcgtg ttcttttccg gctacacttt taagcataaa     2040

atggtctatg aggacacact gactctgttc cccttcagcg gcgaaaccgt gtttatgagc     2100

atggagaatc ccggactgtg gattctgggg tgccacaaca gcgatttcag aaatcgcgga     2160

atgactgccc tgctgaaagt gtcaagctgt gacaagaaca ccggggacta ctatgaagat     2220

tcatacgagg acatcagcgc atatctgctg tccaaaaaca atgccattga accccggtct     2280

tttagtcaga atggcgcgcc aacatcagag agcgccaccc ctgaaagtgg tcccgggagc     2340

gagccagcca catctgggtc ggaaacgcca ggcacaagtg agtctgcaac tcccgagtcc     2400

ggacctggct ccgagcctgc cactagcggc tccgagactc cgggaacttc cgagagcgct     2460

acaccagaaa gcggacccgg aaccagtacc gaacctagcg agggctctgc tccgggcagc     2520

ccagccggct ctcctacatc cacggaggag ggcacttccg aatccgccac cccggagtca     2580

gggccaggat ctgaacccgc tacctcaggc agtgagacgc caggaacgag cgagtccgct     2640

acaccggaga gtgggccagg gagccctgct ggatctccta cgtccactga ggaagggtca     2700

ccagcgggct cgcccaccag cactgaagaa ggtgcctcga gccctccagt gctgaagcgg     2760

caccagcgcg agatcacccg cactaccctg cagagtgatc aggaagagat cgactacgac     2820

gatacaattt ctgtggaaat gaagaaagag gacttcgata tctatgacga agatgagaac     2880

cagagtcctc gatcattcca gaagaaaacc aggcattact ttattgccgc agtggagcgg     2940

ctgtgggatt atggcatgtc ctctagtcct cacgtgctgc gaaatagggc ccagtcagga     3000

agcgtcccac agttcaagaa agtggtcttc caggagttta cagacgggtc ctttactcag     3060

ccactgtaca ggggcgaact gaacgagcac ctgggactgc tggggcccta tatcagagca     3120

gaagtggagg ataacattat ggtcaccttc agaaatcagg cctctcggcc ttacagtttt     3180

tattcaagcc tgatctctta cgaagaggac cagcgacagg gagctgaacc acgaaaaaac     3240

ttcgtgaagc ctaatgagac caaaacatac ttttggaagg tgcagcacca tatggcccca     3300

acaaaagacg agttcgattg caaggcatgg gcctattttt ctgacgtgga tctggagaag     3360

gacgtgcaca gtggcctgat tggcccactg ctggtgtgcc atactaacac cctgaatcca     3420

gcccacggcc ggcaggtcac tgtccaggag ttcgctctgt tctttaccat ctttgatgag     3480

acaaagagct ggtacttcac cgaaaacatg gagcgaaatt gcagggctcc atgtaacatt     3540

cagatggaag accccacatt caaggagaac taccgctttc atgctatcaa tggatacatc     3600

atggatactc tgcccgggct ggtcatggca caggaccaga gaatccggtg gtatctgctg     3660

agcatgggca gcaacgagaa tatccactca attcatttca gcgggcacgt gtttactgtc     3720

aggaagaaag aagagtacaa gatggccctg tacaacctgt atcccggcgt gttcgaaacc     3780

gtcgagatgc tgcctagcaa ggccggaatc tggagagtgg aatgcctgat tggagagcac     3840

ctgcatgctg ggatgtctac cctgtttctg gtgtacagta ataagtgtca gacacccctg     3900

ggaatggcat ccgggcatat cagggatttc cagattaccg catctggaca gtacggacag     3960

tgggcaccta agctggctag actgcactat tccggatcta tcaacgcttg gtccacaaaa     4020

gagcctttct cttggattaa ggtggacctg ctggccccaa tgatcattca tggcatcaaa     4080

actcagggag ctcggcagaa gttctcctct ctgtacatct cacagtttat catcatgtac     4140

agcctggatg ggaagaaatg gcagacatac cgcggcaata gcacaggaac tctgatggtg     4200

ttctttggca acgtggacag cagcggaatc aagcacaaca ttttcaatcc ccctatcatt     4260

gctagataca tccggctgca cccaacccat tattctattc gaagtacact gaggatggaa     4320

ctgatgggat gcgatctgaa cagttgttca atgcccctgg ggatggagtc caaggcaatc     4380

tctgacgccc agattaccgc cagctcctac ttcactaata tgtttgctac ctggagccct     4440

tccaaagcaa gactgcacct gcaaggccgc agcaacgcat ggcgaccaca ggtgaacaat     4500

cccaaggagt ggttgcaggt cgattttcag aaaactatga aggtgaccgg ggtcacaact     4560

cagggcgtga aaagtctgct gacctcaatg tacgtcaagg agttcctgat ctctagttca     4620

caggacggac atcagtggac actgttcttt cagaacggga aggtgaaagt cttccagggc     4680

aatcaggatt cctttacacc tgtggtcaac agtctagacc ctccactgct gaccagatac     4740

ctgagaatcc accctcagtc ctgggtgcac cagattgccc tgagaatgga agtgctggga     4800

tgcgaggccc aggatctgta ctga                                            4824


<210>  21
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MAR/ARS

<400>  21
atattt                                                                   6


<210>  22
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MAR/ARS

<400>  22
aaatat                                                                   6


<210>  23
<211>  5
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  destabilizing element

<400>  23
attta                                                                    5


<210>  24
<211>  5
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  destabilizing element

<400>  24
taaat                                                                    5


<210>  25
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  poly-T site

<400>  25
tttttt                                                                   6


<210>  26
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  poly-A site

<400>  26
aaaaaaa                                                                  7


<210>  27
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  splice site

<400>  27
ggtgat                                                                   6


<210>  28
<211>  5
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TATA box

<400>  28
tataa                                                                    5


<210>  29
<211>  5
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TATA box

<400>  29
ttata                                                                    5


<210>  30
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AU rich sequence element

<400>  30
attttatt                                                                 8


<210>  31
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AU rich sequence element

<400>  31
atttttaa                                                                 8


<210>  32
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  kozak consensus sequence

<400>  32
gccgccacca tgc                                                          13


<210>  33
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTP peptide

<400>  33

Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser 
1               5                   10                  15      


Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu 
            20                  25                  30          


<210>  34
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTP peptide

<400>  34

Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
1               5                   10                  15      


Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
            20                  25              


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  albumin-binding peptide core sequence

<400>  35

Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10      


<210>  36
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAS sequence

<400>  36

Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
1               5                   10                  15      


Ser Ala Pro Ala 
            20  


<210>  37
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAS sequence

<400>  37

Ala Ala Pro Ala Ser Pro Ala Pro Ala Ala Pro Ser Ala Pro Ala Pro 
1               5                   10                  15      


Ala Ala Pro Ser 
            20  


<210>  38
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAS sequence

<400>  38

Ala Pro Ser Ser Pro Ser Pro Ser Ala Pro Ser Ser Pro Ser Pro Ala 
1               5                   10                  15      


Ser Pro Ser Ser 
            20  


<210>  39
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAS sequence

<400>  39

Ala Pro Ser Ser Pro Ser Pro Ser Ala Pro Ser Ser Pro Ser Pro Ala 
1               5                   10                  15      


Ser Pro Ser 
            


<210>  40
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAS sequence

<400>  40

Ser Ser Pro Ser Ala Pro Ser Pro Ser Ser Pro Ala Ser Pro Ser Pro 
1               5                   10                  15      


Ser Ser Pro Ala 
            20  


<210>  41
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAS sequence

<400>  41

Ala Ala Ser Pro Ala Ala Pro Ser Ala Pro Pro Ala Ala Ala Ser Pro 
1               5                   10                  15      


Ala Ala Pro Ser Ala Pro Pro Ala 
            20                  


<210>  42
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAS sequence

<400>  42

Ala Ser Ala Ala Ala Pro Ala Ala Ala Ser Ala Ala Ala Ser Ala Pro 
1               5                   10                  15      


Ser Ala Ala Ala 
            20  


<210>  43
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miR142 target

<400>  43
tccataaagt aggaaacact aca                                               23


<210>  44
<211>  2332
<212>  PRT
<213>  Homo sapiens

<400>  44

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg 
            740                 745                 750         


Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys 
        755                 760                 765             


Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn 
    770                 775                 780                 


Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro 
785                 790                 795                 800 


His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe 
                805                 810                 815     


Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser 
            820                 825                 830         


Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val 
        835                 840                 845             


Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly 
    850                 855                 860                 


Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser 
865                 870                 875                 880 


Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala 
                885                 890                 895     


Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His 
            900                 905                 910         


Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro 
        915                 920                 925             


Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp 
    930                 935                 940                 


Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp 
945                 950                 955                 960 


Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys 
                965                 970                 975     


Arg Ala His Gly Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys 
            980                 985                 990         


Val Ser Ile Ser Leu Leu Lys Thr  Asn Lys Thr Ser Asn  Asn Ser Ala 
        995                 1000                 1005             


Thr Asn  Arg Lys Thr His Ile  Asp Gly Pro Ser Leu  Leu Ile Glu 
    1010                 1015                 1020             


Asn Ser  Pro Ser Val Trp Gln  Asn Ile Leu Glu Ser  Asp Thr Glu 
    1025                 1030                 1035             


Phe Lys  Lys Val Thr Pro Leu  Ile His Asp Arg Met  Leu Met Asp 
    1040                 1045                 1050             


Lys Asn  Ala Thr Ala Leu Arg  Leu Asn His Met Ser  Asn Lys Thr 
    1055                 1060                 1065             


Thr Ser  Ser Lys Asn Met Glu  Met Val Gln Gln Lys  Lys Glu Gly 
    1070                 1075                 1080             


Pro Ile  Pro Pro Asp Ala Gln  Asn Pro Asp Met Ser  Phe Phe Lys 
    1085                 1090                 1095             


Met Leu  Phe Leu Pro Glu Ser  Ala Arg Trp Ile Gln  Arg Thr His 
    1100                 1105                 1110             


Gly Lys  Asn Ser Leu Asn Ser  Gly Gln Gly Pro Ser  Pro Lys Gln 
    1115                 1120                 1125             


Leu Val  Ser Leu Gly Pro Glu  Lys Ser Val Glu Gly  Gln Asn Phe 
    1130                 1135                 1140             


Leu Ser  Glu Lys Asn Lys Val  Val Val Gly Lys Gly  Glu Phe Thr 
    1145                 1150                 1155             


Lys Asp  Val Gly Leu Lys Glu  Met Val Phe Pro Ser  Ser Arg Asn 
    1160                 1165                 1170             


Leu Phe  Leu Thr Asn Leu Asp  Asn Leu His Glu Asn  Asn Thr His 
    1175                 1180                 1185             


Asn Gln  Glu Lys Lys Ile Gln  Glu Glu Ile Glu Lys  Lys Glu Thr 
    1190                 1195                 1200             


Leu Ile  Gln Glu Asn Val Val  Leu Pro Gln Ile His  Thr Val Thr 
    1205                 1210                 1215             


Gly Thr  Lys Asn Phe Met Lys  Asn Leu Phe Leu Leu  Ser Thr Arg 
    1220                 1225                 1230             


Gln Asn  Val Glu Gly Ser Tyr  Asp Gly Ala Tyr Ala  Pro Val Leu 
    1235                 1240                 1245             


Gln Asp  Phe Arg Ser Leu Asn  Asp Ser Thr Asn Arg  Thr Lys Lys 
    1250                 1255                 1260             


His Thr  Ala His Phe Ser Lys  Lys Gly Glu Glu Glu  Asn Leu Glu 
    1265                 1270                 1275             


Gly Leu  Gly Asn Gln Thr Lys  Gln Ile Val Glu Lys  Tyr Ala Cys 
    1280                 1285                 1290             


Thr Thr  Arg Ile Ser Pro Asn  Thr Ser Gln Gln Asn  Phe Val Thr 
    1295                 1300                 1305             


Gln Arg  Ser Lys Arg Ala Leu  Lys Gln Phe Arg Leu  Pro Leu Glu 
    1310                 1315                 1320             


Glu Thr  Glu Leu Glu Lys Arg  Ile Ile Val Asp Asp  Thr Ser Thr 
    1325                 1330                 1335             


Gln Trp  Ser Lys Asn Met Lys  His Leu Thr Pro Ser  Thr Leu Thr 
    1340                 1345                 1350             


Gln Ile  Asp Tyr Asn Glu Lys  Glu Lys Gly Ala Ile  Thr Gln Ser 
    1355                 1360                 1365             


Pro Leu  Ser Asp Cys Leu Thr  Arg Ser His Ser Ile  Pro Gln Ala 
    1370                 1375                 1380             


Asn Arg  Ser Pro Leu Pro Ile  Ala Lys Val Ser Ser  Phe Pro Ser 
    1385                 1390                 1395             


Ile Arg  Pro Ile Tyr Leu Thr  Arg Val Leu Phe Gln  Asp Asn Ser 
    1400                 1405                 1410             


Ser His  Leu Pro Ala Ala Ser  Tyr Arg Lys Lys Asp  Ser Gly Val 
    1415                 1420                 1425             


Gln Glu  Ser Ser His Phe Leu  Gln Gly Ala Lys Lys  Asn Asn Leu 
    1430                 1435                 1440             


Ser Leu  Ala Ile Leu Thr Leu  Glu Met Thr Gly Asp  Gln Arg Glu 
    1445                 1450                 1455             


Val Gly  Ser Leu Gly Thr Ser  Ala Thr Asn Ser Val  Thr Tyr Lys 
    1460                 1465                 1470             


Lys Val  Glu Asn Thr Val Leu  Pro Lys Pro Asp Leu  Pro Lys Thr 
    1475                 1480                 1485             


Ser Gly  Lys Val Glu Leu Leu  Pro Lys Val His Ile  Tyr Gln Lys 
    1490                 1495                 1500             


Asp Leu  Phe Pro Thr Glu Thr  Ser Asn Gly Ser Pro  Gly His Leu 
    1505                 1510                 1515             


Asp Leu  Val Glu Gly Ser Leu  Leu Gln Gly Thr Glu  Gly Ala Ile 
    1520                 1525                 1530             


Lys Trp  Asn Glu Ala Asn Arg  Pro Gly Lys Val Pro  Phe Leu Arg 
    1535                 1540                 1545             


Val Ala  Thr Glu Ser Ser Ala  Lys Thr Pro Ser Lys  Leu Leu Asp 
    1550                 1555                 1560             


Pro Leu  Ala Trp Asp Asn His  Tyr Gly Thr Gln Ile  Pro Lys Glu 
    1565                 1570                 1575             


Glu Trp  Lys Ser Gln Glu Lys  Ser Pro Glu Lys Thr  Ala Phe Lys 
    1580                 1585                 1590             


Lys Lys  Asp Thr Ile Leu Ser  Leu Asn Ala Cys Glu  Ser Asn His 
    1595                 1600                 1605             


Ala Ile  Ala Ala Ile Asn Glu  Gly Gln Asn Lys Pro  Glu Ile Glu 
    1610                 1615                 1620             


Val Thr  Trp Ala Lys Gln Gly  Arg Thr Glu Arg Leu  Cys Ser Gln 
    1625                 1630                 1635             


Asn Pro  Pro Val Leu Lys Arg  His Gln Arg Glu Ile  Thr Arg Thr 
    1640                 1645                 1650             


Thr Leu  Gln Ser Asp Gln Glu  Glu Ile Asp Tyr Asp  Asp Thr Ile 
    1655                 1660                 1665             


Ser Val  Glu Met Lys Lys Glu  Asp Phe Asp Ile Tyr  Asp Glu Asp 
    1670                 1675                 1680             


Glu Asn  Gln Ser Pro Arg Ser  Phe Gln Lys Lys Thr  Arg His Tyr 
    1685                 1690                 1695             


Phe Ile  Ala Ala Val Glu Arg  Leu Trp Asp Tyr Gly  Met Ser Ser 
    1700                 1705                 1710             


Ser Pro  His Val Leu Arg Asn  Arg Ala Gln Ser Gly  Ser Val Pro 
    1715                 1720                 1725             


Gln Phe  Lys Lys Val Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe 
    1730                 1735                 1740             


Thr Gln  Pro Leu Tyr Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu 
    1745                 1750                 1755             


Leu Gly  Pro Tyr Ile Arg Ala  Glu Val Glu Asp Asn  Ile Met Val 
    1760                 1765                 1770             


Thr Phe  Arg Asn Gln Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser 
    1775                 1780                 1785             


Leu Ile  Ser Tyr Glu Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg 
    1790                 1795                 1800             


Lys Asn  Phe Val Lys Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys 
    1805                 1810                 1815             


Val Gln  His His Met Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys 
    1820                 1825                 1830             


Ala Trp  Ala Tyr Phe Ser Asp  Val Asp Leu Glu Lys  Asp Val His 
    1835                 1840                 1845             


Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys His Thr  Asn Thr Leu 
    1850                 1855                 1860             


Asn Pro  Ala His Gly Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu 
    1865                 1870                 1875             


Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu 
    1880                 1885                 1890             


Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu 
    1895                 1900                 1905             


Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly 
    1910                 1915                 1920             


Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln 
    1925                 1930                 1935             


Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile 
    1940                 1945                 1950             


His Ser  Ile His Phe Ser Gly  His Val Phe Thr Val  Arg Lys Lys 
    1955                 1960                 1965             


Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe 
    1970                 1975                 1980             


Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val 
    1985                 1990                 1995             


Glu Cys  Leu Ile Gly Glu His  Leu His Ala Gly Met  Ser Thr Leu 
    2000                 2005                 2010             


Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala 
    2015                 2020                 2025             


Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr 
    2030                 2035                 2040             


Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser 
    2045                 2050                 2055             


Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val 
    2060                 2065                 2070             


Asp Leu  Leu Ala Pro Met Ile  Ile His Gly Ile Lys  Thr Gln Gly 
    2075                 2080                 2085             


Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile 
    2090                 2095                 2100             


Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn 
    2105                 2110                 2115             


Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly Asn Val  Asp Ser Ser 
    2120                 2125                 2130             


Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr 
    2135                 2140                 2145             


Ile Arg  Leu His Pro Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg 
    2150                 2155                 2160             


Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu 
    2165                 2170                 2175             


Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser 
    2180                 2185                 2190             


Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala 
    2195                 2200                 2205             


Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val 
    2210                 2215                 2220             


Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met 
    2225                 2230                 2235             


Lys Val  Thr Gly Val Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr 
    2240                 2245                 2250             


Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly 
    2255                 2260                 2265             


His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe 
    2270                 2275                 2280             


Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp 
    2285                 2290                 2295             


Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp 
    2300                 2305                 2310             


Val His  Gln Ile Ala Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala 
    2315                 2320                 2325             


Gln Asp  Leu Tyr 
    2330         


<210>  45
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 233-236 of human IgG1

<400>  45

Glu Leu Leu Gly 
1               


<210>  46
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AE42-4, protein sequence

<400>  46

Gly Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
1               5                   10                  15      


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 
            20                  25                  30          


Thr Ser Gly Ser Glu Thr Pro Ala Ser Ser 
        35                  40          


<210>  47
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AE42-4, DNA sequence

<400>  47
ggcgcgccag gttctcctgc tggctccccc acctcaacag aagaggggac aagcgaaagc       60

gctacgcctg agagtggccc tggctctgag ccagccacct ccggctctga aacccctgcc      120

tcgagc                                                                 126


<210>  48
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-2A, protein sequence

<400>  48

Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
        35                  40                  45              


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 
    50                  55                  60                  


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
65                  70                  75                  80  


Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 
                85                  90                  95      


Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 
            100                 105                 110         


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        115                 120                 125             


Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
    130                 135                 140                 


<210>  49
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-2A, DNA sequence

<400>  49
ggcgcgccaa ccagtacgga gccgtccgag gggagcgcac caggaagccc ggctgggagc       60

ccgacttcta ccgaagaggg tacatctacc gaaccaagtg aaggttcagc accaggcacc      120

tcaacagaac cctctgaggg ctcggcgcct ggtacaagtg agtccgccac cccagaatcc      180

gggcctggga caagcacaga accttcggaa gggagtgccc ctggaacatc cgaatcggca      240

accccagaat cagggccagg atctgagccc gcgacttcgg gctccgagac gcctgggaca      300

tccaccgagc cctccgaagg atcagcccca ggcaccagca cggagccctc tgagggaagc      360

gcacctggta ccagcgaaag cgcaactccc gaatcaggtc ccggtacgag cgagtcggcg      420

accccggaga gcgggccagg tgcctcgagc                                       450


<210>  50
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-3B, protein sequence

<400>  50

Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 
            20                  25                  30          


Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
        35                  40                  45              


Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 
    50                  55                  60                  


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
65                  70                  75                  80  


Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
                85                  90                  95      


Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 
            100                 105                 110         


Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
        115                 120                 125             


Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
    130                 135                 140                 


<210>  51
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-3B, DNA sequence

<400>  51
ggcgcgccaa gtcccgctgg aagcccaact agcaccgaag aggggacctc agagtccgcc       60

acccccgagt ccggccctgg ctctgagcct gccactagcg gctccgagac tcctggcaca      120

tccgaaagcg ctacacccga gagtggaccc ggcacctcta ccgagcccag tgagggctcc      180

gcccctggaa caagcaccga gcccagcgaa ggcagcgccc cagggacctc cacagagccc      240

agtgaaggca gtgctcctgg caccagcacc gaaccaagcg agggctctgc acccgggacc      300

tccaccgagc caagcgaagg ctctgcccct ggcacttcca ccgagcccag cgaaggcagc      360

gcccctggga gccccgctgg ctctcccacc agcactgagg agggcacatc taccgaacca      420

agtgaaggct ctgcaccagg tgcctcgagc                                       450


<210>  52
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-4A, protein sequence

<400>  52

Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
            20                  25                  30          


Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 
        35                  40                  45              


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 
    50                  55                  60                  


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
65                  70                  75                  80  


Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
                85                  90                  95      


Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly 
            100                 105                 110         


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        115                 120                 125             


Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
    130                 135                 140                 


<210>  53
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-4A, DNA sequence

<400>  53
ggcgcgccaa cgtccgaaag tgctacccct gagtcaggcc ctggtagtga gcctgccaca       60

agcggaagcg aaactccggg gacctcagag tctgccactc ccgaatcggg gccaggctct      120

gaaccggcca cttcagggag cgaaacacca ggaacatcgg agagcgctac cccggagagc      180

gggccaggaa ctagtactga gcctagcgag ggaagtgcac ctggtacaag cgagtccgcc      240

acacccgagt ctggccctgg ctctccagcg ggctcaccca cgagcactga agagggctct      300

cccgctggca gcccaacgtc gacagaagaa ggatcaccag caggctcccc cacatcaaca      360

gaggagggta catcagaatc tgctactccc gagagtggac ccggtacctc cactgagccc      420

agcgagggga gtgcaccagg tgcctcgagc                                       450


<210>  54
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-5A, protein sequence

<400>  54

Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
            20                  25                  30          


Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 
        35                  40                  45              


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 
    50                  55                  60                  


Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
65                  70                  75                  80  


Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
                85                  90                  95      


Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
            100                 105                 110         


Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
        115                 120                 125             


Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
    130                 135                 140                 


<210>  55
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-5A, DNA sequence

<400>  55
ggcgcgccaa catcagagag cgccacccct gaaagtggtc ccgggagcga gccagccaca       60

tctgggtcgg aaacgccagg cacaagtgag tctgcaactc ccgagtccgg acctggctcc      120

gagcctgcca ctagcggctc cgagactccg ggaacttccg agagcgctac accagaaagc      180

ggacccggaa ccagtaccga acctagcgag ggctctgctc cgggcagccc agccggctct      240

cctacatcca cggaggaggg cacttccgaa tccgccaccc cggagtcagg gccaggatct      300

gaacccgcta cctcaggcag tgagacgcca ggaacgagcg agtccgctac accggagagt      360

gggccaggga gccctgctgg atctcctacg tccactgagg aagggtcacc agcgggctcg      420

cccaccagca ctgaagaagg tgcctcgagc                                       450


<210>  56
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-6B, protein sequence

<400>  56

Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
            20                  25                  30          


Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
        35                  40                  45              


Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
    50                  55                  60                  


Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
65                  70                  75                  80  


Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
                85                  90                  95      


Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala 
            100                 105                 110         


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        115                 120                 125             


Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
    130                 135                 140                 


<210>  57
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-6B, DNA sequence

<400>  57
ggcgcgccaa catctaccga gccttccgaa ggctctgccc ctgggacctc agaatctgca       60

acccctgaaa gcggccctgg aacctccgaa agtgccactc ccgagagcgg cccagggaca      120

agcgagtcag caacccctga gtctggaccc ggcagcgagc ctgcaacctc tggctcagag      180

actcccggct cagaacccgc tacctcaggc tccgagacac ccggctctcc tgctgggagt      240

cccacttcca ccgaggaagg aacatccact gagcctagtg agggctctgc ccctggaacc      300

agcacagagc caagtgaggg cagtgcacca ggatccgagc cagcaaccag cgggtccgag      360

actcccggga cctctgagtc tgccacccca gagagcggac ccggcacttc aaccgagccc      420

tccgaaggat cagcaccagg tgcctcgagc                                       450


<210>  58
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-1, protein sequence

<400>  58

Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser 
1               5                   10                  15      


Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr 
            20                  25                  30          


Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 
        35                  40                  45              


Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser 
    50                  55                  60                  


Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr 
65                  70                  75                  80  


Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 
                85                  90                  95      


Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser 
            100                 105                 110         


Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser 
        115                 120                 125             


Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser 
    130                 135                 140                 


<210>  59
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-1, DNA sequence

<400>  59
ggcgcgccac ccgggtcgtc cccgtcggcg tccaccggaa cagggccagg gtcatccccg       60

tcagcgtcga ctgggacggg acccgggaca cccggttcgg ggactgcatc ctcctcgcct      120

ggttcgtcca ccccgtcagg agccacgggt tcgccgggaa gcagcccaag cgcatccact      180

ggtacagggc ctggggcttc accgggtact tcatccacgg ggtcaccggg aacgcccgga      240

tcggggacgg cttcctcatc accaggatcg tcaacaccct cgggcgcaac gggcagcccc      300

ggaacccctg gttcgggtac ggcgtcgtcg agccccggtg cgagcccggg aacaagctcg      360

acaggatcgc ctggggcgtc acccggcacg tcgagcacag gcagccccgg aacccctgga      420

tcgggaaccg cgtcgtcaag cgcctcgagc                                       450


<210>  60
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-A, protein sequence

<400>  60

Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Pro 
1               5                   10                  15      


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 
            20                  25                  30          


Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 
        35                  40                  45              


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 
    50                  55                  60                  


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 
65                  70                  75                  80  


Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 
                85                  90                  95      


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly 
            100                 105                 110         


Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
        115                 120                 125             


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
    130                 135                 140                 


<210>  61
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-A, DNA sequence

<400>  61
ggcgcgccag gtgcctcgcc gggaacatca tcaactggtt cacccgggtc atccccctcg       60

gcctcaaccg ggacgggtcc cggctcatcc cccagcgcca gcactggaac aggtcctggc      120

actcctggtt ccggtacggc atcgtcatcc ccgggaagct caacaccgtc cggagcgaca      180

ggatcacctg gctcgtcacc ttcggcgtca actggaacgg ggccaggggc ctcacccgga      240

acgtcctcga ctgggtcgcc tggtacgccg ggatcaggaa cggcctcatc ctcgcctggg      300

tcctcaacgc cctcgggtgc gactggttcg ccgggaactc ctggctcggg gacggcctcg      360

tcgtcgcctg gggcatcacc ggggacgagc tccacggggt cccctggagc gtcaccgggg      420

acctcctcga caggtagccc ggcctcgagc                                       450


<210>  62
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-B, protein sequence

<400>  62

Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 
1               5                   10                  15      


Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
            20                  25                  30          


Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 
        35                  40                  45              


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 
    50                  55                  60                  


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 
65                  70                  75                  80  


Gly Thr Gly Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 
                85                  90                  95      


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro 
            100                 105                 110         


Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
        115                 120                 125             


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
    130                 135                 140                 


<210>  63
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-B, DNA sequence

<400>  63
ggcgcgccag gtacaccggg cagcggcacg gcttcgtcgt cacccggctc gtccacaccg       60

tcgggagcta cgggaagccc aggagcgtca ccgggaacgt cgtcaacggg gtcaccgggt      120

acgccaggta gcggcacggc cagcagctcg ccaggttcat cgaccccgtc gggagcgact      180

gggtcgcccg gatcaagccc gtcagcttcc actggaacag gacccgggtc gtcgccgtca      240

gcctcaacgg ggacaggacc tggttcatcg acgccgtcag gggcgacagg ctcgcccgga      300

tcgtcaacac cctcgggggc aacggggagc cctggtgcgt cgcctggaac ctcatccacc      360

ggaagcccgg gggcctcgcc gggtacgagc tccacgggat cgcccggagc gtcccccgga      420

acttcaagca cagggagccc tgcctcgagc                                       450


<210>  64
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-C, protein sequence

<400>  64

Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro 
1               5                   10                  15      


Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
            20                  25                  30          


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
        35                  40                  45              


Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly 
    50                  55                  60                  


Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
65                  70                  75                  80  


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
                85                  90                  95      


Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr 
            100                 105                 110         


Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 
        115                 120                 125             


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
    130                 135                 140                 


<210>  65
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-C, DNA sequence

<400>  65
ggcgcgccag gtacacccgg atcgggtaca gcgtcatcga gccccggtgc gtcacctggt       60

acgtcgagca cggggtcgcc aggggcgtcc cctgggacgt cctcaacagg ctcgcccggt      120

gcgtcacccg gcacgtcgtc cacgggttca cctggtagct ccccttccgc gtccactggc      180

accgggcctg gaactccggg gagcggcaca gcgagctcgt cgccgggagc atcgcctggg      240

acatcgagca ccgggtcgcc aggagcatcg cccggaacat ccagcacagg aagccccggc      300

gcgtcgcccg ggacatcaag cacaggttcc ccgggatcga gcacgccgtc cggagccact      360

ggatcaccag ggagctcgac accttccggc gcaacgggat cgcccggagc cagcccgggt      420

acgtcaagca ctggctcccc tgcctcgagc                                       450


<210>  66
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-F, protein sequence

<400>  66

Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro 
1               5                   10                  15      


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 
            20                  25                  30          


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
        35                  40                  45              


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 
    50                  55                  60                  


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 
65                  70                  75                  80  


Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 
                85                  90                  95      


Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 
            100                 105                 110         


Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 
        115                 120                 125             


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
    130                 135                 140                 


<210>  67
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-F, DNA sequence

<400>  67
ggcgcgccag gctccagccc ctccgcgagc acgggaaccg gaccaggttc gtcaccctca       60

gcatcaacgg ggacgggacc gggggcgtca ccaggaacgt cctccaccgg ctcgccgggt      120

gcatcacccg gaacgtcatc gaccggatcg ccagggagct cgacgccatc aggcgcaaca      180

ggatcacctg gctcaagccc tagcgcgtca accggcacgg gtccgggtgc ctcccctggc      240

acgtccagca ccggatcacc cggatcgagc ccatccgcct caaccggaac cggacccggt      300

acaccagggt cgggaacagc ctcctcgtca ccaggctcct caaccccctc gggagccacg      360

ggttcgcccg gttcgtcaac gccttccgga gcaactggta gccccggagc atcgccagga      420

acttcgagca cggggtcgcc cgcctcgagc                                       450


<210>  68
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-1  DNA Sequence

<400>  68
atgcagattg agctgtctac ttgctttttc ctgtgcctgc tgaggttttg cttttccgct       60

acacgaaggt attatctggg ggctgtggaa ctgtcttggg attacatgca gagtgacctg      120

ggagagctgc cagtggacgc aaggtttccc cctagagtcc ctaagtcatt ccccttcaac      180

actagcgtgg tctacaagaa aacactgttc gtggagttta ctgatcacct gttcaacatc      240

gcaaagccta ggccaccctg gatgggactg ctggggccaa caatccaggc cgaggtgtac      300

gacaccgtgg tcattacact taagaacatg gcctcacacc ccgtgagcct gcatgctgtg      360

ggcgtcagct actggaaggc ttccgaagga gcagagtatg acgatcagac ttcccagaga      420

gaaaaagagg acgataaggt gtttcctggc ggatctcata cctacgtgtg gcaggtcctg      480

aaagagaatg gccctatggc ctccgaccct ctgtgcctga cctactctta tctgagtcac      540

gtggacctgg tcaaggatct gaacagcggc ctgatcggag ccctgctggt gtgcagggaa      600

ggaagcctgg ctaaggagaa aacccagaca ctgcataagt tcattctgct gttcgccgtg      660

tttgacgaag ggaaatcatg gcacagcgag acaaagaata gtctgatgca ggacagggat      720

gccgcttcag ccagagcttg gcccaaaatg cacactgtga acggctacgt caatcgctca      780

ctgcctgggc tgatcggctg ccaccgaaag agcgtgtatt ggcatgtcat cgggatgggc      840

accacacctg aagtgcactc cattttcctg gagggacata cctttctggt ccgcaaccac      900

cgacaggctt ccctggagat ctctccaatt accttcctga cagcacagac tctgctgatg      960

gacctggggc agttcctgct gttttgccac atcagctccc accagcatga tggcatggag     1020

gcttacgtga aagtggactc ttgtcccgag gaacctcagc tgcggatgaa gaacaatgag     1080

gaagcagaag actatgacga tgacctgacc gactccgaga tggatgtggt ccgattcgat     1140

gacgataaca gcccctcctt tatccagatt agatctgtgg ccaagaaaca ccctaagaca     1200

tgggtccatt acatcgcagc cgaggaagag gactgggatt atgcaccact ggtgctggca     1260

ccagacgatc gctcctacaa atctcagtat ctgaacaatg ggccacagag gattggcaga     1320

aagtacaaga aagtgcggtt catggcatat accgatgaga ccttcaagac tcgcgaagcc     1380

atccagcacg agagcggcat cctgggacca ctgctgtacg gagaagtggg agacaccctg     1440

ctgatcattt tcaagaacca ggccagccgg ccttacaata tctatccaca tgggattaca     1500

gatgtgcgcc ctctgtacag caggagactg ccaaagggcg tcaaacacct gaaggacttc     1560

ccaatcctgc ccggagaaat cttcaagtac aagtggactg tcaccgtcga ggatggcccc     1620

actaagagcg accctcggtg cctgacccgc tactattcta gtttcgtgaa tatggaaaga     1680

gatctggcaa gcggactgat cggaccactg ctgatttgtt acaaagagag cgtggatcag     1740

agaggcaacc agatcatgtc cgacaagcgg aatgtgattc tgttcagtgt ctttgacgaa     1800

aacaggtcat ggtacctgac cgagaacatc cagagattcc tgcctaatcc agctggggtg     1860

cagctggaag atcctgagtt tcaggcatct aacatcatgc atagtattaa tggctacgtg     1920

ttcgacagtt tgcagctgag cgtgtgcctg cacgaggtcg cttactggta tatcctgagc     1980

attggggcac agacagattt cctgagcgtg ttcttttccg gctacacttt taagcataaa     2040

atggtctatg aggacacact gactctgttc cccttcagcg gcgaaaccgt gtttatgagc     2100

atggagaatc ccggactgtg gattctgggg tgccacaaca gcgatttcag aaatcgcgga     2160

atgactgccc tgctgaaagt gtcaagctgt gacaagaaca ccggggacta ctatgaagat     2220

tcatacgagg acatcagcgc atatctgctg tccaaaaaca atgccattga accccggtct     2280

tttagtcaga atcctccagt gctgaagagg caccagaggg agatcacccg cactaccctg     2340

cagagtgatc aggaagagat cgactacgac gatacaattt ctgtggaaat gaagaaagag     2400

gacttcgata tctatgacga agatgagaac cagagtcctc gatcattcca gaagaaaacc     2460

aggcattact ttattgccgc agtggagcgg ctgtgggatt atggcatgtc ctctagtcct     2520

cacgtgctgc gaaatagggc ccagtcagga agcgtcccac agttcaagaa agtggtcttc     2580

caggagttta cagacgggtc ctttactcag ccactgtaca ggggcgaact gaacgagcac     2640

ctgggactgc tggggcccta tatcagagca gaagtggagg ataacattat ggtcaccttc     2700

agaaatcagg cctctcggcc ttacagtttt tattcaagcc tgatctctta cgaagaggac     2760

cagcgacagg gagctgaacc acgaaaaaac ttcgtgaagc ctaatgagac caaaacatac     2820

ttttggaagg tgcagcacca tatggcccca acaaaagacg agttcgattg caaggcatgg     2880

gcctattttt ctgacgtgga tctggagaag gacgtgcaca gtggcctgat tggcccactg     2940

ctggtgtgcc atactaacac cctgaatcca gcccacggcc ggcaggtcac tgtccaggag     3000

ttcgctctgt tctttaccat ctttgatgag acaaagagct ggtacttcac cgaaaacatg     3060

gagcgaaatt gcagggctcc atgtaacatt cagatggaag accccacatt caaggagaac     3120

taccgctttc atgctatcaa tggatacatc atggatactc tgcccgggct ggtcatggca     3180

caggaccaga gaatccggtg gtatctgctg agcatgggca gcaacgagaa tatccactca     3240

attcatttca gcgggcacgt gtttactgtc aggaagaaag aagagtacaa gatggccctg     3300

tacaacctgt atcccggcgt gttcgaaacc gtcgagatgc tgcctagcaa ggccggaatc     3360

tggagagtgg aatgcctgat tggagagcac ctgcatgctg ggatgtctac cctgtttctg     3420

gtgtacagta ataagtgtca gacacccctg ggaatggcat ccgggcatat cagggatttc     3480

cagattaccg catctggaca gtacggacag tgggcaccta agctggctag actgcactat     3540

tccggatcta tcaacgcttg gtccacaaaa gagcctttct cttggattaa ggtggacctg     3600

ctggccccaa tgatcattca tggcatcaaa actcagggag ctcggcagaa gttctcctct     3660

ctgtacatct cacagtttat catcatgtac agcctggatg ggaagaaatg gcagacatac     3720

cgcggcaata gcacaggaac tctgatggtg ttctttggca acgtggacag cagcggaatc     3780

aagcacaaca ttttcaatcc ccctatcatt gctagataca tccggctgca cccaacccat     3840

tattctattc gaagtacact gaggatggaa ctgatgggat gcgatctgaa cagttgttca     3900

atgcccctgg ggatggagtc caaggcaatc tctgacgccc agattaccgc cagctcctac     3960

ttcactaata tgtttgctac ctggagccct tccaaagcaa gactgcacct gcaaggccgc     4020

agcaacgcat ggcgaccaca ggtgaacaat cccaaggagt ggttgcaggt cgattttcag     4080

aaaactatga aggtgaccgg ggtcacaact cagggcgtga aaagtctgct gacctcaatg     4140

tacgtcaagg agttcctgat ctctagttca caggacggac atcagtggac actgttcttt     4200

cagaacggga aggtgaaagt cttccagggc aatcaggatt cctttacacc tgtggtcaac     4260

agtctagacc ctccactgct gaccagatac ctgagaatcc accctcagtc ctgggtgcac     4320

cagattgccc tgagaatgga agtgctggga tgcgaggccc aggatctgta ctga           4374


<210>  69
<211>  577
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ET Promoter, DNA sequence

<400>  69
ctcgaggtca attcacgcga gttaataatt accagcgcgg gccaaataaa taatccgcga       60

ggggcaggtg acgtttgccc agcgcgcgct ggtaattatt aacctcgcga atattgattc      120

gaggccgcga ttgccgcaat cgcgaggggc aggtgacctt tgcccagcgc gcgttcgccc      180

cgccccggac ggtatcgata agcttaggag cttgggctgc aggtcgaggg cactgggagg      240

atgttgagta agatggaaaa ctactgatga cccttgcaga gacagagtat taggacatgt      300

ttgaacaggg gccgggcgat cagcaggtag ctctagagga tccccgtctg tctgcacatt      360

tcgtagagcg agtgttccga tactctaatc tccctaggca aggttcatat ttgtgtaggt      420

tacttattct ccttttgttg actaagtcaa taatcagaat cagcaggttt ggagtcagct      480

tggcagggat cagcagcctg ggttggaagg agggggtata aaagcccctt caccaggaga      540

agccgtcaca cagatccaca agctcctgcc accatgg                               577


<210>  70
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-5

<400>  70
atgcaaatcg aactgagcac ctgtttcttc ctctgcctgc tgagattctg tttctccgcg       60

acccgccgat actacctggg agcagtggag ctctcctggg attacatgca gagcgacctt      120

ggggagctgc ccgtggatgc caggttccct ccccgggtgc caaagtcgtt tccgttcaac      180

acctccgtgg tgtacaagaa aactctgttc gtggagttca ccgaccacct gttcaatatc      240

gccaagccca gacctccctg gatggggctg ttgggaccta ccatccaagc ggaggtgtac      300

gacactgtgg tcatcactct gaagaacatg gcctcgcatc ccgtgtccct gcacgccgtg      360

ggagtgtctt actggaaagc gtccgagggg gccgaatacg acgaccagac ctcgcagaga      420

gaaaaggaag atgacaaggt gttcccagga ggatcgcaca cctacgtgtg gcaagtgttg      480

aaggagaacg gcccaatggc ctccgacccg ctgtgcctga cctactcgta cctgtcccac      540

gtggacctcg tgaaggacct caactcggga ctgattggag ccctgctggt ctgcagggaa      600

ggctcactgg cgaaagaaaa gactcagacc ttgcacaagt tcattctgct gttcgctgtg      660

ttcgacgagg ggaagtcgtg gcacagcgag actaagaact ccctgatgca agatagagat      720

gccgcctccg cccgggcctg gcctaagatg cacaccgtga acggttacgt gaaccgctcc      780

ctccctggcc tgattggatg ccaccggaag tccgtgtact ggcacgtgat cgggatgggg      840

accacccccg aggtgcacag catcttcctg gaaggtcaca catttctcgt gcgcaaccac      900

cggcaggcct ccctggaaat cagccccatt accttcctca ctgcccagac tctgctgatg      960

gacctgggac agttcctgct gttctgccat atctcctccc accaacatga cggaatggag     1020

gcatacgtga aggtcgattc ctgccctgag gaaccccagc tccgcatgaa gaacaatgag     1080

gaagccgagg actacgacga cgacctgacg gatagcgaga tggatgtggt ccggttcgat     1140

gacgataaca gcccttcctt catccaaatt cgctcggtgg caaagaagca ccccaagacc     1200

tgggtgcatt acattgcggc ggaagaagag gactgggatt atgccccgct tgtcctcgct     1260

cctgacgacc ggagctacaa gagccagtac ctgaacaacg gtccacagag gatcggtaga     1320

aagtacaaga aggtccgctt catggcctat accgacgaaa ccttcaaaac tagagaggcc     1380

atccaacacg aatccggcat cctgggcccg ctcttgtacg gagaagtcgg cgacaccctt     1440

ctcattatct tcaagaacca ggcttcccgg ccgtacaaca tctatccgca tgggatcact     1500

gacgtgcgcc cactgtactc gcggcgcctg cccaagggtg tcaaacacct gaaggatttt     1560

ccgatccttc cgggagaaat cttcaagtac aagtggaccg tgaccgtgga agatggccca     1620

actaagtctg accctagatg cctcacccgc tactactcat ccttcgtcaa catggagcgc     1680

gacctggcca gcggactgat cggcccgctg ctgatttgct acaaggaatc agtggaccaa     1740

cggggaaacc agatcatgtc ggataagagg aacgtcatcc tcttctccgt gtttgacgaa     1800

aaccggtcgt ggtacctgac tgaaaacatc cagcggttcc tccccaaccc cgcgggcgtg     1860

cagctggaag atcctgagtt tcaggcatca aacatcatgc actccattaa cggctacgtg     1920

ttcgattcgc tgcagctgag cgtgtgtctg cacgaagtgg cctactggta catcctgtcc     1980

attggtgccc agactgactt cctgtccgtg tttttctccg gctacacgtt caagcacaag     2040

atggtgtacg aggacaccct gaccctcttc cctttttccg gcgaaactgt gtttatgagc     2100

atggagaatc ccggcctgtg gatcttgggc tgccacaaca gcgacttccg taacagagga     2160

atgactgcgc tgctcaaggt gtccagctgc gacaagaaca ccggagacta ttatgaggac     2220

tcatacgagg acatctccgc ctacctcctg tccaagaata acgccattga acctcggagc     2280

ttcagccaga acccacccgt gcttaagaga catcaacggg agatcactag gaccaccctg     2340

cagtcagacc aggaggaaat cgactacgat gacaccatct cggtcgagat gaagaaggag     2400

gactttgaca tctacgacga agatgaaaac cagagcccga ggtcgttcca aaagaaaacc     2460

cgccactact ttattgctgc tgtcgagcgg ctgtgggact acggaatgtc gtcctcgccg     2520

cacgtgctcc gcaaccgagc ccagagcggc tcggtgccgc aattcaagaa ggtcgtgttc     2580

caggagttca ctgacgggag cttcactcag cctttgtacc ggggagaact caatgaacat     2640

ctcggcctcc tcggacctta catcagagca gaagtggaag ataacatcat ggtcactttc     2700

cgtaaccaag ccagccgccc gtactcgttc tactcctccc tcatttctta cgaagaggac     2760

cagcggcagg gcgcagaacc gcgcaagaac ttcgtgaagc ccaacgaaac caagacctac     2820

ttctggaaag tgcagcatca tatggccccg actaaggacg agtttgactg caaagcctgg     2880

gcctacttct ccgatgtgga cttggagaag gacgtccact ccggcctcat cggtcccctg     2940

ctcgtgtgcc ataccaatac cctgaacccc gcacacggtc gccaggtcac cgtgcaggag     3000

ttcgctctgt tcttcactat cttcgacgaa actaagtcct ggtacttcac cgagaacatg     3060

gagaggaact gcagagcccc ctgtaacatc cagatggagg acccgacgtt caaggaaaac     3120

taccggttcc acgccattaa cggatacatc atggatacgc tgccgggtct tgtgatggcc     3180

caggatcaac ggatcagatg gtacttattg tcgatgggca gcaacgagaa catccactct     3240

attcacttct ccggtcatgt gttcactgtg cggaagaagg aagagtacaa gatggccctg     3300

tacaaccttt atcccggagt gttcgaaact gtggaaatgc tgccgtcgaa ggccggcatt     3360

tggcgcgtgg agtgtttgat tggagaacat ctccatgcgg ggatgtcaac cctgttcctg     3420

gtgtatagca acaagtgcca gactccgctt gggatggcgt caggacacat tagggatttc     3480

cagatcactg cgtccggcca gtacggccaa tgggccccta agctggcccg cctgcattac     3540

tccggatcca ttaacgcctg gtcaaccaag gagccattct cctggatcaa ggtggacctt     3600

ctggccccca tgattatcca cggaattaag acccaggggg cccggcagaa gttctcctca     3660

ctgtacatca gccagttcat aatcatgtac tccctggacg gaaagaagtg gcaaacctac     3720

agggggaaca gcaccggcac actgatggtc tttttcggaa atgtggactc ctccgggatt     3780

aagcataaca tcttcaaccc tccgattatc gctcggtaca ttagacttca ccctacccac     3840

tacagcattc gctccaccct gcggatggaa ctgatgggct gcgatctgaa ctcgtgcagc     3900

atgccgttgg gaatggagtc caaagcaatt tccgacgcgc agatcaccgc ctcgtcctac     3960

tttaccaaca tgttcgccac gtggtcaccg tccaaggccc ggctgcacct ccagggaaga     4020

tccaacgcat ggcggccaca ggtcaacaac cctaaggagt ggctccaggt ggacttccag     4080

aaaaccatga aggtcaccgg agtcacaacc cagggagtga agtcgctgct gacttctatg     4140

tacgtcaagg agttcctgat ctccagcagc caggacgggc accagtggac cctgttcttc     4200

caaaatggaa aggtcaaggt gtttcagggc aatcaggatt cattcacccc ggtggtgaac     4260

tcccttgatc cacccctcct gacccgctac cttcgcatcc acccacagtc ctgggtgcac     4320

cagatcgcgc tgaggatgga ggtcctggga tgcgaagccc aggacctgta ctga           4374


<210>  71
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-6

<400>  71
atgcagattg agctgtccac ttgtttcttc ctgtgcctcc tgcgcttctg tttctccgcc       60

actcgccggt actaccttgg agccgtggag ctttcatggg actacatgca gagcgacctg      120

ggcgaactcc ccgtggatgc cagattcccc ccccgcgtgc caaagtcctt cccctttaac      180

acctccgtgg tgtacaagaa aaccctcttt gtcgagttca ctgaccacct gttcaacatc      240

gccaagccgc gcccaccttg gatgggcctc ctgggaccga ccattcaagc tgaagtgtac      300

gacaccgtgg tgatcaccct gaagaacatg gcgtcccacc ccgtgtccct gcatgcggtc      360

ggagtgtcct actggaaggc ctccgaagga gctgagtacg acgaccagac tagccagcgg      420

gaaaaggagg acgataaagt gttcccgggc ggctcgcata cttacgtgtg gcaagtcctg      480

aaggaaaacg gacctatggc atccgatcct ctgtgcctga cttactccta cctttcccat      540

gtggacctcg tgaaggacct gaacagcggg ctgattggtg cacttctcgt gtgccgcgaa      600

ggttcgctcg ctaaggaaaa gacccagacc ctccataagt tcatcctttt gttcgctgtg      660

ttcgatgaag gaaagtcatg gcattccgaa actaagaact cgctgatgca ggaccgggat      720

gccgcctcag cccgcgcctg gcctaaaatg catacagtca acggatacgt gaatcggtca      780

ctgcccgggc tcatcggttg tcacagaaag tccgtgtact ggcacgtcat cggcatgggc      840

actacgcctg aagtgcactc catcttcctg gaagggcaca ccttcctcgt gcgcaaccac      900

cgccaggcct ctctggaaat ctccccgatt acctttctga ccgcccagac tctgctcatg      960

gacctggggc agttccttct cttctgccac atctccagcc atcagcacga cggaatggag     1020

gcctacgtga aggtggactc atgcccggaa gaacctcagt tgcggatgaa gaacaacgag     1080

gaggccgagg actatgacga cgatttgact gactccgaga tggacgtcgt gcggttcgat     1140

gacgacaaca gccccagctt catccagatt cgcagcgtgg ccaagaagca ccccaaaacc     1200

tgggtgcact acatcgcggc cgaggaagaa gattgggact acgccccgtt ggtgctggca     1260

cccgatgacc ggtcgtacaa gtcccagtat ctgaacaatg gtccgcagcg gattggcaga     1320

aagtacaaga aagtgcggtt catggcgtac actgacgaaa cgtttaagac ccgggaggcc     1380

attcaacatg agagcggcat tctgggacca ctgctgtacg gagaggtcgg cgataccctg     1440

ctcatcatct tcaaaaacca ggcctcccgg ccttacaaca tctaccctca cggaatcacc     1500

gacgtgcggc cactctactc gcggcgcctg ccgaagggcg tcaagcacct gaaagacttc     1560

cctatcctgc cgggcgaaat cttcaagtat aagtggaccg tcaccgtgga ggacgggccc     1620

accaagagcg atcctaggtg tctgactcgg tactactcca gcttcgtgaa catggaacgg     1680

gacctggcat cgggactcat tggaccgctg ctgatctgct acaaagagtc ggtggatcaa     1740

cgcggcaacc agatcatgtc cgacaagcgc aacgtgatcc tgttctccgt gtttgatgaa     1800

aacagatcct ggtacctcac tgaaaacatc cagaggttcc tcccaaaccc cgcaggagtg     1860

caactggagg accctgagtt tcaggcctcg aatatcatgc actcgattaa cggttacgtg     1920

ttcgactcgc tgcagctgag cgtgtgcctc catgaagtcg cttactggta cattctgtcc     1980

atcggcgccc agactgactt cctgagcgtg ttcttttccg gttacacctt taagcacaag     2040

atggtgtacg aagataccct gaccctgttc cctttctccg gcgaaacggt gttcatgtcg     2100

atggagaacc cgggtctgtg gattctggga tgccacaaca gcgactttcg gaaccgcgga     2160

atgactgccc tgctgaaggt gtcctcatgc gacaagaaca ccggagacta ctacgaggac     2220

tcctacgagg atatctcagc ctacctcctg tccaagaaca acgcgatcga gccgcgcagc     2280

ttcagccaga acccgcctgt gctgaagagg caccagcgag aaattacccg gaccaccctc     2340

caatcggatc aggaggaaat cgactacgac gacaccatct cggtggaaat gaagaaggaa     2400

gatttcgata tctacgacga ggacgaaaat cagtcccctc gctcattcca aaagaaaact     2460

agacactact ttatcgccgc ggtggaaaga ctgtgggact atggaatgtc atccagccct     2520

cacgtccttc ggaaccgggc ccagagcgga tcggtgcctc agttcaagaa agtggtgttc     2580

caggagttca ccgacggcag cttcacccag ccgctgtacc ggggagaact gaacgaacac     2640

ctgggcctgc tcggtcccta catccgcgcg gaagtggagg ataacatcat ggtgaccttc     2700

cgtaaccaag catccagacc ttactccttc tattcctccc tgatctcata cgaggaggac     2760

cagcgccaag gcgccgagcc ccgcaagaac ttcgtcaagc ccaacgagac taagacctac     2820

ttctggaagg tccaacacca tatggccccg accaaggatg agtttgactg caaggcctgg     2880

gcctacttct ccgacgtgga ccttgagaag gatgtccatt ccggcctgat cgggccgctg     2940

ctcgtgtgtc acaccaacac cctgaaccca gcgcatggac gccaggtcac cgtccaggag     3000

tttgctctgt tcttcaccat ttttgacgaa actaagtcct ggtacttcac cgagaatatg     3060

gagcgaaact gtagagcgcc ctgcaatatc cagatggaag atccgacttt caaggagaac     3120

tatagattcc acgccatcaa cgggtacatc atggatactc tgccggggct ggtcatggcc     3180

caggatcaga ggattcggtg gtacttgctg tcaatgggat cgaacgaaaa cattcactcc     3240

attcacttct ccggtcacgt gttcactgtg cgcaagaagg aggagtacaa gatggcgctg     3300

tacaatctgt accccggggt gttcgaaact gtggagatgc tgccgtccaa ggccggcatc     3360

tggagagtgg agtgcctgat cggagagcac ctccacgcgg ggatgtccac cctcttcctg     3420

gtgtactcga ataagtgcca gaccccgctg ggcatggcct cgggccacat cagagacttc     3480

cagatcacag caagcggaca atacggccaa tgggcgccga agctggcccg cttgcactac     3540

tccggatcga tcaacgcatg gtccaccaag gaaccgttct cgtggattaa ggtggacctc     3600

ctggccccta tgattatcca cggaattaag acccagggcg ccaggcagaa gttctcctcc     3660

ctgtacatct cgcaattcat catcatgtac agcctggacg ggaagaagtg gcagacttac     3720

aggggaaact ccaccggcac cctgatggtc tttttcggca acgtggattc ctccggcatt     3780

aagcacaaca tcttcaaccc accgatcata gccagatata ttaggctcca ccccactcac     3840

tactcaatcc gctcaactct tcggatggaa ctcatggggt gcgacctgaa ctcctgctcc     3900

atgccgttgg ggatggaatc aaaggctatt agcgacgccc agatcaccgc gagctcctac     3960

ttcactaaca tgttcgccac ctggagcccc tccaaggcca ggctgcactt gcagggacgg     4020

tcaaatgcct ggcggccgca agtgaacaat ccgaaggaat ggcttcaagt ggatttccaa     4080

aagaccatga aagtgaccgg agtcaccacc cagggagtga agtcccttct gacctcgatg     4140

tatgtgaagg agttcctgat tagcagcagc caggacgggc accagtggac cctgttcttc     4200

caaaacggaa aggtcaaggt gttccagggg aaccaggact cgttcacacc cgtggtgaac     4260

tccctggacc ccccactgct gacgcggtac ttgaggattc atcctcagtc ctgggtccat     4320

cagattgcat tgcgaatgga agtcctgggc tgcgaggccc aggacctgta ctga           4374


<210>  72
<211>  4824
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-6-XTEN

<400>  72
atgcagattg agctgtccac ttgtttcttc ctgtgcctcc tgcgcttctg tttctccgcc       60

actcgccggt actaccttgg agccgtggag ctttcatggg actacatgca gagcgacctg      120

ggcgaactcc ccgtggatgc cagattcccc ccccgcgtgc caaagtcctt cccctttaac      180

acctccgtgg tgtacaagaa aaccctcttt gtcgagttca ctgaccacct gttcaacatc      240

gccaagccgc gcccaccttg gatgggcctc ctgggaccga ccattcaagc tgaagtgtac      300

gacaccgtgg tgatcaccct gaagaacatg gcgtcccacc ccgtgtccct gcatgcggtc      360

ggagtgtcct actggaaggc ctccgaagga gctgagtacg acgaccagac tagccagcgg      420

gaaaaggagg acgataaagt gttcccgggc ggctcgcata cttacgtgtg gcaagtcctg      480

aaggaaaacg gacctatggc atccgatcct ctgtgcctga cttactccta cctttcccat      540

gtggacctcg tgaaggacct gaacagcggg ctgattggtg cacttctcgt gtgccgcgaa      600

ggttcgctcg ctaaggaaaa gacccagacc ctccataagt tcatcctttt gttcgctgtg      660

ttcgatgaag gaaagtcatg gcattccgaa actaagaact cgctgatgca ggaccgggat      720

gccgcctcag cccgcgcctg gcctaaaatg catacagtca acggatacgt gaatcggtca      780

ctgcccgggc tcatcggttg tcacagaaag tccgtgtact ggcacgtcat cggcatgggc      840

actacgcctg aagtgcactc catcttcctg gaagggcaca ccttcctcgt gcgcaaccac      900

cgccaggcct ctctggaaat ctccccgatt acctttctga ccgcccagac tctgctcatg      960

gacctggggc agttccttct cttctgccac atctccagcc atcagcacga cggaatggag     1020

gcctacgtga aggtggactc atgcccggaa gaacctcagt tgcggatgaa gaacaacgag     1080

gaggccgagg actatgacga cgatttgact gactccgaga tggacgtcgt gcggttcgat     1140

gacgacaaca gccccagctt catccagatt cgcagcgtgg ccaagaagca ccccaaaacc     1200

tgggtgcact acatcgcggc cgaggaagaa gattgggact acgccccgtt ggtgctggca     1260

cccgatgacc ggtcgtacaa gtcccagtat ctgaacaatg gtccgcagcg gattggcaga     1320

aagtacaaga aagtgcggtt catggcgtac actgacgaaa cgtttaagac ccgggaggcc     1380

attcaacatg agagcggcat tctgggacca ctgctgtacg gagaggtcgg cgataccctg     1440

ctcatcatct tcaaaaacca ggcctcccgg ccttacaaca tctaccctca cggaatcacc     1500

gacgtgcggc cactctactc gcggcgcctg ccgaagggcg tcaagcacct gaaagacttc     1560

cctatcctgc cgggcgaaat cttcaagtat aagtggaccg tcaccgtgga ggacgggccc     1620

accaagagcg atcctaggtg tctgactcgg tactactcca gcttcgtgaa catggaacgg     1680

gacctggcat cgggactcat tggaccgctg ctgatctgct acaaagagtc ggtggatcaa     1740

cgcggcaacc agatcatgtc cgacaagcgc aacgtgatcc tgttctccgt gtttgatgaa     1800

aacagatcct ggtacctcac tgaaaacatc cagaggttcc tcccaaaccc cgcaggagtg     1860

caactggagg accctgagtt tcaggcctcg aatatcatgc actcgattaa cggttacgtg     1920

ttcgactcgc tgcagctgag cgtgtgcctc catgaagtcg cttactggta cattctgtcc     1980

atcggcgccc agactgactt cctgagcgtg ttcttttccg gttacacctt taagcacaag     2040

atggtgtacg aagataccct gaccctgttc cctttctccg gcgaaacggt gttcatgtcg     2100

atggagaacc cgggtctgtg gattctggga tgccacaaca gcgactttcg gaaccgcgga     2160

atgactgccc tgctgaaggt gtcctcatgc gacaagaaca ccggagacta ctacgaggac     2220

tcctacgagg atatctcagc ctacctcctg tccaagaaca acgcgatcga gccgcgcagc     2280

ttcagccaga acggcgcgcc aacatcagag agcgccaccc ctgaaagtgg tcccgggagc     2340

gagccagcca catctgggtc ggaaacgcca ggcacaagtg agtctgcaac tcccgagtcc     2400

ggacctggct ccgagcctgc cactagcggc tccgagactc cgggaacttc cgagagcgct     2460

acaccagaaa gcggacccgg aaccagtacc gaacctagcg agggctctgc tccgggcagc     2520

ccagccggct ctcctacatc cacggaggag ggcacttccg aatccgccac cccggagtca     2580

gggccaggat ctgaacccgc tacctcaggc agtgagacgc caggaacgag cgagtccgct     2640

acaccggaga gtgggccagg gagccctgct ggatctccta cgtccactga ggaagggtca     2700

ccagcgggct cgcccaccag cactgaagaa ggtgcctcga gcccgcctgt gctgaagagg     2760

caccagcgag aaattacccg gaccaccctc caatcggatc aggaggaaat cgactacgac     2820

gacaccatct cggtggaaat gaagaaggaa gatttcgata tctacgacga ggacgaaaat     2880

cagtcccctc gctcattcca aaagaaaact agacactact ttatcgccgc ggtggaaaga     2940

ctgtgggact atggaatgtc atccagccct cacgtccttc ggaaccgggc ccagagcgga     3000

tcggtgcctc agttcaagaa agtggtgttc caggagttca ccgacggcag cttcacccag     3060

ccgctgtacc ggggagaact gaacgaacac ctgggcctgc tcggtcccta catccgcgcg     3120

gaagtggagg ataacatcat ggtgaccttc cgtaaccaag catccagacc ttactccttc     3180

tattcctccc tgatctcata cgaggaggac cagcgccaag gcgccgagcc ccgcaagaac     3240

ttcgtcaagc ccaacgagac taagacctac ttctggaagg tccaacacca tatggccccg     3300

accaaggatg agtttgactg caaggcctgg gcctacttct ccgacgtgga ccttgagaag     3360

gatgtccatt ccggcctgat cgggccgctg ctcgtgtgtc acaccaacac cctgaaccca     3420

gcgcatggac gccaggtcac cgtccaggag tttgctctgt tcttcaccat ttttgacgaa     3480

actaagtcct ggtacttcac cgagaatatg gagcgaaact gtagagcgcc ctgcaatatc     3540

cagatggaag atccgacttt caaggagaac tatagattcc acgccatcaa cgggtacatc     3600

atggatactc tgccggggct ggtcatggcc caggatcaga ggattcggtg gtacttgctg     3660

tcaatgggat cgaacgaaaa cattcactcc attcacttct ccggtcacgt gttcactgtg     3720

cgcaagaagg aggagtacaa gatggcgctg tacaatctgt accccggggt gttcgaaact     3780

gtggagatgc tgccgtccaa ggccggcatc tggagagtgg agtgcctgat cggagagcac     3840

ctccacgcgg ggatgtccac cctcttcctg gtgtactcga ataagtgcca gaccccgctg     3900

ggcatggcct cgggccacat cagagacttc cagatcacag caagcggaca atacggccaa     3960

tgggcgccga agctggcccg cttgcactac tccggatcga tcaacgcatg gtccaccaag     4020

gaaccgttct cgtggattaa ggtggacctc ctggccccta tgattatcca cggaattaag     4080

acccagggcg ccaggcagaa gttctcctcc ctgtacatct cgcaattcat catcatgtac     4140

agcctggacg ggaagaagtg gcagacttac aggggaaact ccaccggcac cctgatggtc     4200

tttttcggca acgtggattc ctccggcatt aagcacaaca tcttcaaccc accgatcata     4260

gccagatata ttaggctcca ccccactcac tactcaatcc gctcaactct tcggatggaa     4320

ctcatggggt gcgacctgaa ctcctgctcc atgccgttgg ggatggaatc aaaggctatt     4380

agcgacgccc agatcaccgc gagctcctac ttcactaaca tgttcgccac ctggagcccc     4440

tccaaggcca ggctgcactt gcagggacgg tcaaatgcct ggcggccgca agtgaacaat     4500

ccgaaggaat ggcttcaagt ggatttccaa aagaccatga aagtgaccgg agtcaccacc     4560

cagggagtga agtcccttct gacctcgatg tatgtgaagg agttcctgat tagcagcagc     4620

caggacgggc accagtggac cctgttcttc caaaacggaa aggtcaaggt gttccagggg     4680

aaccaggact cgttcacacc cgtggtgaac tccctggacc ccccactgct gacgcggtac     4740

ttgaggattc atcctcagtc ctgggtccat cagattgcat tgcgaatgga agtcctgggc     4800

tgcgaggccc aggacctgta ctga                                            4824


<210>  73
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD motif

<400>  73

Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser 
1               5                   10          


<210>  74
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD motif

<400>  74

Gly Ser Glu Gly Ser Ser Gly Pro Gly Glu Ser Ser 
1               5                   10          


<210>  75
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD motif

<400>  75

Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro 
1               5                   10          


<210>  76
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD motif

<400>  76

Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser 
1               5                   10          


<210>  77
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AE, AM motif

<400>  77

Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 
1               5                   10          


<210>  78
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AE, AM, AQ motif

<400>  78

Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
1               5                   10          


<210>  79
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AE, AM, AQ motif

<400>  79

Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
1               5                   10          


<210>  80
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AE, AM, AQ motif

<400>  80

Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
1               5                   10          


<210>  81
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF, AM motif

<400>  81

Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 
1               5                   10          


<210>  82
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF, AM motif

<400>  82

Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 
1               5                   10          


<210>  83
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF, AM motif

<400>  83

Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro 
1               5                   10          


<210>  84
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF, AM motif

<400>  84

Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 
1               5                   10          


<210>  85
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AG, AM motif

<400>  85

Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 
1               5                   10          


<210>  86
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AG, AM motif

<400>  86

Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 
1               5                   10          


<210>  87
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AG, AM motif

<400>  87

Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 
1               5                   10          


<210>  88
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AG, AM motif

<400>  88

Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
1               5                   10          


<210>  89
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AQ motif

<400>  89

Gly Glu Pro Ala Gly Ser Pro Thr Ser Thr Ser Glu 
1               5                   10          


<210>  90
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AQ motif

<400>  90

Gly Thr Gly Glu Pro Ser Ser Thr Pro Ala Ser Glu 
1               5                   10          


<210>  91
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AQ motif

<400>  91

Gly Ser Gly Pro Ser Thr Glu Ser Ala Pro Thr Glu 
1               5                   10          


<210>  92
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AQ motif

<400>  92

Gly Ser Glu Thr Pro Ser Gly Pro Ser Glu Thr Ala 
1               5                   10          


<210>  93
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AQ motif

<400>  93

Gly Pro Ser Glu Thr Ser Thr Ser Glu Pro Gly Ala 
1               5                   10          


<210>  94
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AQ motif

<400>  94

Gly Ser Pro Ser Glu Pro Thr Glu Gly Thr Ser Ala 
1               5                   10          


<210>  95
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC motif

<400>  95

Gly Ser Gly Ala Ser Glu Pro Thr Ser Thr Glu Pro 
1               5                   10          


<210>  96
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC motif

<400>  96

Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser 
1               5                   10          


<210>  97
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC motif

<400>  97

Gly Thr Ser Glu Pro Ser Thr Ser Glu Pro Gly Ala 
1               5                   10          


<210>  98
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC motif

<400>  98

Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala 
1               5                   10          


<210>  99
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BD motif

<400>  99

Gly Ser Thr Ala Gly Ser Glu Thr Ser Thr Glu Ala 
1               5                   10          


<210>  100
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BD motif

<400>  100

Gly Ser Glu Thr Ala Thr Ser Gly Ser Glu Thr Ala 
1               5                   10          


<210>  101
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BD motif

<400>  101

Gly Thr Ser Glu Ser Ala Thr Ser Glu Ser Gly Ala 
1               5                   10          


<210>  102
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BD motif

<400>  102

Gly Thr Ser Thr Glu Ala Ser Glu Gly Ser Ala Ser 
1               5                   10          


<210>  103
<211>  1607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  coFVIII-6-XTEN Protein Sequence

<400>  103

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Gly Ala Pro Thr 
        755                 760                 765             


Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 
    770                 775                 780                 


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
785                 790                 795                 800 


Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 
                805                 810                 815     


Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 
            820                 825                 830         


Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 
        835                 840                 845             


Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 
    850                 855                 860                 


Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 
865                 870                 875                 880 


Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 
                885                 890                 895     


Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ala 
            900                 905                 910         


Ser Ser Pro Pro Val Leu Lys Arg His Gln Arg Glu Ile Thr Arg Thr 
        915                 920                 925             


Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser 
    930                 935                 940                 


Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn 
945                 950                 955                 960 


Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala 
                965                 970                 975     


Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val 
            980                 985                 990         


Leu Arg Asn Arg Ala Gln Ser Gly  Ser Val Pro Gln Phe  Lys Lys Val 
        995                 1000                 1005             


Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe Thr Gln  Pro Leu Tyr 
    1010                 1015                 1020             


Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu Leu Gly  Pro Tyr Ile 
    1025                 1030                 1035             


Arg Ala  Glu Val Glu Asp Asn  Ile Met Val Thr Phe  Arg Asn Gln 
    1040                 1045                 1050             


Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser Leu Ile  Ser Tyr Glu 
    1055                 1060                 1065             


Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg Lys Asn  Phe Val Lys 
    1070                 1075                 1080             


Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys Val Gln  His His Met 
    1085                 1090                 1095             


Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys Ala Trp  Ala Tyr Phe 
    1100                 1105                 1110             


Ser Asp  Val Asp Leu Glu Lys  Asp Val His Ser Gly  Leu Ile Gly 
    1115                 1120                 1125             


Pro Leu  Leu Val Cys His Thr  Asn Thr Leu Asn Pro  Ala His Gly 
    1130                 1135                 1140             


Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe 
    1145                 1150                 1155             


Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn 
    1160                 1165                 1170             


Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys 
    1175                 1180                 1185             


Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr 
    1190                 1195                 1200             


Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr 
    1205                 1210                 1215             


Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile His Ser  Ile His Phe 
    1220                 1225                 1230             


Ser Gly  His Val Phe Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met 
    1235                 1240                 1245             


Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met 
    1250                 1255                 1260             


Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly 
    1265                 1270                 1275             


Glu His  Leu His Ala Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser 
    1280                 1285                 1290             


Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala Ser Gly  His Ile Arg 
    1295                 1300                 1305             


Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro 
    1310                 1315                 1320             


Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser 
    1325                 1330                 1335             


Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro 
    1340                 1345                 1350             


Met Ile  Ile His Gly Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe 
    1355                 1360                 1365             


Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp 
    1370                 1375                 1380             


Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu 
    1385                 1390                 1395             


Met Val  Phe Phe Gly Asn Val  Asp Ser Ser Gly Ile  Lys His Asn 
    1400                 1405                 1410             


Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro 
    1415                 1420                 1425             


Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly 
    1430                 1435                 1440             


Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys 
    1445                 1450                 1455             


Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn 
    1460                 1465                 1470             


Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln 
    1475                 1480                 1485             


Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu 
    1490                 1495                 1500             


Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met Lys Val  Thr Gly Val 
    1505                 1510                 1515             


Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys 
    1520                 1525                 1530             


Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu 
    1535                 1540                 1545             


Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp 
    1550                 1555                 1560             


Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr 
    1565                 1570                 1575             


Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp Val His  Gln Ile Ala 
    1580                 1585                 1590             


Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr 
    1595                 1600                 1605         


<210>  104
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rep-binding site (RBS) for AAV2

<400>  104
gcgcgctcgc tcgctc                                                       16


<210>  105
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  terminal resolution site (TRS) for AAV2

<400>  105
agttgg                                                                   6


<210>  106
<211>  2328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mature full length FVIII

<400>  106

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Lys Arg Arg Leu Pro Lys Gly Val Lys His Leu 
                485                 490                 495     


Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr 
            500                 505                 510         


Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr 
        515                 520                 525             


Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly 
    530                 535                 540                 


Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg 
545                 550                 555                 560 


Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val 
                565                 570                 575     


Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe 
            580                 585                 590         


Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala 
        595                 600                 605             


Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln 
    610                 615                 620                 


Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile 
625                 630                 635                 640 


Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe 
                645                 650                 655     


Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser 
            660                 665                 670         


Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu 
        675                 680                 685             


Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu 
    690                 695                 700                 


Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser 
705                 710                 715                 720 


Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu 
                725                 730                 735     


Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys 
            740                 745                 750         


Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp 
        755                 760                 765             


Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser 
    770                 775                 780                 


Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly 
785                 790                 795                 800 


Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp 
                805                 810                 815     


Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met 
            820                 825                 830         


Thr His Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr 
        835                 840                 845             


Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr 
    850                 855                 860                 


Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser 
865                 870                 875                 880 


Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr 
                885                 890                 895     


Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp 
            900                 905                 910         


Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr 
        915                 920                 925             


Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys 
    930                 935                 940                 


Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys 
945                 950                 955                 960 


Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala 
                965                 970                 975     


His Gly Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser 
            980                 985                 990         


Ile Ser Leu Leu Lys Thr Asn Lys  Thr Ser Asn Asn Ser  Ala Thr Asn 
        995                 1000                 1005             


Arg Lys  Thr His Ile Asp Gly  Pro Ser Leu Leu Ile  Glu Asn Ser 
    1010                 1015                 1020             


Pro Ser  Val Trp Gln Asn Ile  Ser Asp Thr Glu Phe  Lys Lys Val 
    1025                 1030                 1035             


Thr Pro  Leu Ile His Asp Arg  Met Leu Met Asp Lys  Asn Ala Thr 
    1040                 1045                 1050             


Ala Leu  Arg Leu Asn His Met  Ser Asn Lys Thr Thr  Ser Ser Lys 
    1055                 1060                 1065             


Asn Met  Glu Met Val Gln Gln  Lys Lys Glu Gly Pro  Ile Pro Pro 
    1070                 1075                 1080             


Asp Ala  Gln Asn Pro Asp Met  Ser Phe Phe Lys Met  Leu Phe Leu 
    1085                 1090                 1095             


Pro Glu  Ser Ala Arg Trp Ile  Gln Arg Thr His Gly  Lys Asn Ser 
    1100                 1105                 1110             


Leu Asn  Ser Gly Gln Gly Pro  Ser Pro Lys Gln Leu  Val Ser Leu 
    1115                 1120                 1125             


Gly Pro  Glu Lys Ser Val Glu  Gly Gln Asn Phe Leu  Ser Glu Lys 
    1130                 1135                 1140             


Asn Lys  Val Val Val Gly Lys  Gly Glu Phe Thr Lys  Asp Val Gly 
    1145                 1150                 1155             


Leu Lys  Glu Met Val Phe Pro  Ser Ser Arg Asn Leu  Phe Leu Thr 
    1160                 1165                 1170             


Asn Leu  Asp Asn Leu His Glu  Asn Asn Thr His Asn  Gln Glu Lys 
    1175                 1180                 1185             


Lys Ile  Gln Glu Glu Ile Glu  Lys Lys Glu Thr Leu  Ile Gln Glu 
    1190                 1195                 1200             


Asn Val  Val Leu Pro Gln Ile  His Thr Val Thr Gly  Thr Lys Asn 
    1205                 1210                 1215             


Phe Met  Lys Asn Leu Phe Leu  Leu Ser Thr Arg Gln  Asn Val Glu 
    1220                 1225                 1230             


Gly Ser  Tyr Asp Gly Ala Tyr  Ala Pro Val Leu Gln  Asp Phe Arg 
    1235                 1240                 1245             


Ser Leu  Asn Asp Ser Thr Asn  Arg Thr Lys Lys His  Thr Ala His 
    1250                 1255                 1260             


Phe Ser  Lys Lys Gly Glu Glu  Glu Asn Leu Glu Gly  Leu Gly Asn 
    1265                 1270                 1275             


Gln Thr  Lys Gln Ile Val Glu  Lys Tyr Ala Cys Thr  Thr Arg Ile 
    1280                 1285                 1290             


Ser Pro  Asn Thr Ser Gln Gln  Asn Phe Val Thr Gln  Arg Ser Lys 
    1295                 1300                 1305             


Arg Ala  Leu Lys Gln Phe Arg  Leu Pro Leu Glu Glu  Thr Glu Leu 
    1310                 1315                 1320             


Glu Lys  Arg Ile Ile Val Asp  Asp Thr Ser Thr Gln  Trp Ser Lys 
    1325                 1330                 1335             


Asn Met  Lys His Leu Thr Pro  Ser Thr Leu Thr Gln  Ile Asp Tyr 
    1340                 1345                 1350             


Asn Glu  Lys Glu Lys Gly Ala  Ile Thr Gln Ser Pro  Leu Ser Asp 
    1355                 1360                 1365             


Cys Leu  Thr Arg Ser His Ser  Ile Pro Gln Ala Asn  Arg Ser Pro 
    1370                 1375                 1380             


Leu Pro  Ile Ala Lys Val Ser  Ser Phe Pro Ser Ile  Arg Pro Ile 
    1385                 1390                 1395             


Tyr Leu  Thr Arg Val Leu Phe  Gln Asp Asn Ser Ser  His Leu Pro 
    1400                 1405                 1410             


Ala Ala  Ser Tyr Arg Lys Lys  Asp Ser Gly Val Gln  Glu Ser Ser 
    1415                 1420                 1425             


His Phe  Leu Gln Gly Ala Lys  Lys Asn Asn Leu Ser  Leu Ala Ile 
    1430                 1435                 1440             


Leu Thr  Leu Glu Met Thr Gly  Asp Gln Arg Glu Val  Gly Ser Leu 
    1445                 1450                 1455             


Gly Thr  Ser Ala Thr Asn Ser  Val Thr Tyr Lys Lys  Val Glu Asn 
    1460                 1465                 1470             


Thr Val  Leu Pro Lys Pro Asp  Leu Pro Lys Thr Ser  Gly Lys Val 
    1475                 1480                 1485             


Glu Leu  Leu Pro Lys Val His  Ile Tyr Gln Lys Asp  Leu Phe Pro 
    1490                 1495                 1500             


Thr Glu  Thr Ser Asn Gly Ser  Pro Gly His Leu Asp  Leu Val Glu 
    1505                 1510                 1515             


Gly Ser  Leu Leu Gln Gly Thr  Glu Gly Ala Ile Lys  Trp Asn Glu 
    1520                 1525                 1530             


Ala Asn  Arg Pro Gly Lys Val  Pro Phe Leu Arg Val  Ala Thr Glu 
    1535                 1540                 1545             


Ser Ser  Ala Lys Thr Pro Ser  Lys Leu Leu Asp Pro  Leu Ala Trp 
    1550                 1555                 1560             


Asp Asn  His Tyr Gly Thr Gln  Ile Pro Lys Glu Glu  Trp Lys Ser 
    1565                 1570                 1575             


Gln Glu  Lys Ser Pro Glu Lys  Thr Ala Phe Lys Lys  Lys Asp Thr 
    1580                 1585                 1590             


Ile Leu  Ser Leu Asn Ala Cys  Glu Ser Asn His Ala  Ile Ala Ala 
    1595                 1600                 1605             


Ile Asn  Glu Gly Gln Asn Lys  Pro Glu Ile Glu Val  Thr Trp Ala 
    1610                 1615                 1620             


Lys Gln  Gly Arg Thr Glu Arg  Leu Cys Ser Gln Asn  Pro Pro Val 
    1625                 1630                 1635             


Leu Lys  Arg His Gln Arg Glu  Ile Thr Arg Thr Thr  Leu Gln Ser 
    1640                 1645                 1650             


Asp Gln  Glu Glu Ile Asp Tyr  Asp Asp Thr Ile Ser  Val Glu Met 
    1655                 1660                 1665             


Lys Lys  Glu Asp Phe Asp Ile  Tyr Asp Glu Asp Glu  Asn Gln Ser 
    1670                 1675                 1680             


Pro Arg  Ser Phe Gln Lys Lys  Thr Arg His Tyr Phe  Ile Ala Ala 
    1685                 1690                 1695             


Val Glu  Arg Leu Trp Asp Tyr  Gly Met Ser Ser Ser  Pro His Val 
    1700                 1705                 1710             


Leu Arg  Asn Arg Ala Gln Ser  Gly Ser Val Pro Gln  Phe Lys Lys 
    1715                 1720                 1725             


Val Val  Phe Gln Glu Phe Thr  Asp Gly Ser Phe Thr  Gln Pro Leu 
    1730                 1735                 1740             


Tyr Arg  Gly Glu Leu Asn Glu  His Leu Gly Leu Leu  Gly Pro Tyr 
    1745                 1750                 1755             


Ile Arg  Ala Glu Val Glu Asp  Asn Ile Met Val Thr  Phe Arg Asn 
    1760                 1765                 1770             


Gln Ala  Ser Arg Pro Tyr Ser  Phe Tyr Ser Ser Leu  Ile Ser Tyr 
    1775                 1780                 1785             


Glu Glu  Asp Gln Arg Gln Gly  Ala Glu Pro Arg Lys  Asn Phe Val 
    1790                 1795                 1800             


Lys Pro  Asn Glu Thr Lys Thr  Tyr Phe Trp Lys Val  Gln His His 
    1805                 1810                 1815             


Met Ala  Pro Thr Lys Asp Glu  Phe Asp Cys Lys Ala  Trp Ala Tyr 
    1820                 1825                 1830             


Phe Ser  Asp Val Asp Leu Glu  Lys Asp Val His Ser  Gly Leu Ile 
    1835                 1840                 1845             


Gly Pro  Leu Leu Val Cys His  Thr Asn Thr Leu Asn  Pro Ala His 
    1850                 1855                 1860             


Gly Arg  Gln Val Thr Val Gln  Glu Phe Ala Leu Phe  Phe Thr Ile 
    1865                 1870                 1875             


Phe Asp  Glu Thr Lys Ser Trp  Tyr Phe Thr Glu Asn  Met Glu Arg 
    1880                 1885                 1890             


Asn Cys  Arg Ala Pro Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe 
    1895                 1900                 1905             


Lys Glu  Asn Tyr Arg Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp 
    1910                 1915                 1920             


Thr Leu  Pro Gly Leu Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp 
    1925                 1930                 1935             


Tyr Leu  Leu Ser Met Gly Ser  Asn Glu Asn Ile His  Ser Ile His 
    1940                 1945                 1950             


Phe Ser  Gly His Val Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys 
    1955                 1960                 1965             


Met Ala  Leu Tyr Asn Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu 
    1970                 1975                 1980             


Met Leu  Pro Ser Lys Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile 
    1985                 1990                 1995             


Gly Glu  His Leu His Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr 
    2000                 2005                 2010             


Ser Asn  Lys Cys Gln Thr Pro  Leu Gly Met Ala Ser  Gly His Ile 
    2015                 2020                 2025             


Arg Asp  Phe Gln Ile Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala 
    2030                 2035                 2040             


Pro Lys  Leu Ala Arg Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp 
    2045                 2050                 2055             


Ser Thr  Lys Glu Pro Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala 
    2060                 2065                 2070             


Pro Met  Ile Ile His Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys 
    2075                 2080                 2085             


Phe Ser  Ser Leu Tyr Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu 
    2090                 2095                 2100             


Asp Gly  Lys Lys Trp Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr 
    2105                 2110                 2115             


Leu Met  Val Phe Phe Gly Asn  Val Asp Ser Ser Gly  Ile Lys His 
    2120                 2125                 2130             


Asn Ile  Phe Asn Pro Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His 
    2135                 2140                 2145             


Pro Thr  His Tyr Ser Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met 
    2150                 2155                 2160             


Gly Cys  Asp Leu Asn Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser 
    2165                 2170                 2175             


Lys Ala  Ile Ser Asp Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr 
    2180                 2185                 2190             


Asn Met  Phe Ala Thr Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu 
    2195                 2200                 2205             


Gln Gly  Arg Ser Asn Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys 
    2210                 2215                 2220             


Glu Trp  Leu Gln Val Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly 
    2225                 2230                 2235             


Val Thr  Thr Gln Gly Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val 
    2240                 2245                 2250             


Lys Glu  Phe Leu Ile Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr 
    2255                 2260                 2265             


Leu Phe  Phe Gln Asn Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln 
    2270                 2275                 2280             


Asp Ser  Phe Thr Pro Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu 
    2285                 2290                 2295             


Thr Arg  Tyr Leu Arg Ile His  Pro Gln Ser Trp Val  His Gln Ile 
    2300                 2305                 2310             


Ala Leu  Arg Met Glu Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr 
    2315                 2320                 2325             


<210>  107
<211>  7053
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mature full length FVIII

<400>  107
atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc       60

accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc      120

ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac      180

acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc      240

gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat      300

gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt      360

ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg      420

gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg      480

aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat      540

gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa      600

gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta      660

tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat      720

gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct      780

ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc      840

accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat      900

cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg      960

gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa     1020

gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa     1080

gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat     1140

gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact     1200

tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc     1260

cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg     1320

aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct     1380

attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg     1440

ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact     1500

gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt     1560

ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca     1620

actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga     1680

gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa     1740

agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag     1800

aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg     1860

cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt     1920

tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc     1980

attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa     2040

atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg     2100

atggaaaacc caggtctatg gattctgggg tgccacaact cagactttcg gaacagaggc     2160

atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac     2220

agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc     2280

ttctcccaga attcaagaca ccctagcact aggcaaaagc aatttaatgc caccacaatt     2340

ccagaaaatg acatagagaa gactgaccct tggtttgcac acagaacacc tatgcctaaa     2400

atacaaaatg tctcctctag tgatttgttg atgctcttgc gacagagtcc tactccacat     2460

gggctatcct tatctgatct ccaagaagcc aaatatgaga ctttttctga tgatccatca     2520

cctggagcaa tagacagtaa taacagcctg tctgaaatga cacacttcag gccacagctc     2580

catcacagtg gggacatggt atttacccct gagtcaggcc tccaattaag attaaatgag     2640

aaactgggga caactgcagc aacagagttg aagaaacttg atttcaaagt ttctagtaca     2700

tcaaataatc tgatttcaac aattccatca gacaatttgg cagcaggtac tgataataca     2760

agttccttag gacccccaag tatgccagtt cattatgata gtcaattaga taccactcta     2820

tttggcaaaa agtcatctcc ccttactgag tctggtggac ctctgagctt gagtgaagaa     2880

aataatgatt caaagttgtt agaatcaggt ttaatgaata gccaagaaag ttcatgggga     2940

aaaaatgtat cgtcaacaga gagtggtagg ttatttaaag ggaaaagagc tcatggacct     3000

gctttgttga ctaaagataa tgccttattc aaagttagca tctctttgtt aaagacaaac     3060

aaaacttcca ataattcagc aactaataga aagactcaca ttgatggccc atcattatta     3120

attgagaata gtccatcagt ctggcaaaat atattagaaa gtgacactga gtttaaaaaa     3180

gtgacacctt tgattcatga cagaatgctt atggacaaaa atgctacagc tttgaggcta     3240

aatcatatgt caaataaaac tacttcatca aaaaacatgg aaatggtcca acagaaaaaa     3300

gagggcccca ttccaccaga tgcacaaaat ccagatatgt cgttctttaa gatgctattc     3360

ttgccagaat cagcaaggtg gatacaaagg actcatggaa agaactctct gaactctggg     3420

caaggcccca gtccaaagca attagtatcc ttaggaccag aaaaatctgt ggaaggtcag     3480

aatttcttgt ctgagaaaaa caaagtggta gtaggaaagg gtgaatttac aaaggacgta     3540

ggactcaaag agatggtttt tccaagcagc agaaacctat ttcttactaa cttggataat     3600

ttacatgaaa ataatacaca caatcaagaa aaaaaaattc aggaagaaat agaaaagaag     3660

gaaacattaa tccaagagaa tgtagttttg cctcagatac atacagtgac tggcactaag     3720

aatttcatga agaacctttt cttactgagc actaggcaaa atgtagaagg ttcatatgac     3780

ggggcatatg ctccagtact tcaagatttt aggtcattaa atgattcaac aaatagaaca     3840

aagaaacaca cagctcattt ctcaaaaaaa ggggaggaag aaaacttgga aggcttggga     3900

aatcaaacca agcaaattgt agagaaatat gcatgcacca caaggatatc tcctaataca     3960

agccagcaga attttgtcac gcaacgtagt aagagagctt tgaaacaatt cagactccca     4020

ctagaagaaa cagaacttga aaaaaggata attgtggatg acacctcaac ccagtggtcc     4080

aaaaacatga aacatttgac cccgagcacc ctcacacaga tagactacaa tgagaaggag     4140

aaaggggcca ttactcagtc tcccttatca gattgcctta cgaggagtca tagcatccct     4200

caagcaaata gatctccatt acccattgca aaggtatcat catttccatc tattagacct     4260

atatatctga ccagggtcct attccaagac aactcttctc atcttccagc agcatcttat     4320

agaaagaaag attctggggt ccaagaaagc agtcatttct tacaaggagc caaaaaaaat     4380

aacctttctt tagccattct aaccttggag atgactggtg atcaaagaga ggttggctcc     4440

ctggggacaa gtgccacaaa ttcagtcaca tacaagaaag ttgagaacac tgttctcccg     4500

aaaccagact tgcccaaaac atctggcaaa gttgaattgc ttccaaaagt tcacatttat     4560

cagaaggacc tattccctac ggaaactagc aatgggtctc ctggccatct ggatctcgtg     4620

gaagggagcc ttcttcaggg aacagaggga gcgattaagt ggaatgaagc aaacagacct     4680

ggaaaagttc cctttctgag agtagcaaca gaaagctctg caaagactcc ctccaagcta     4740

ttggatcctc ttgcttggga taaccactat ggtactcaga taccaaaaga agagtggaaa     4800

tcccaagaga agtcaccaga aaaaacagct tttaagaaaa aggataccat tttgtccctg     4860

aacgcttgtg aaagcaatca tgcaatagca gcaataaatg agggacaaaa taagcccgaa     4920

atagaagtca cctgggcaaa gcaaggtagg actgaaaggc tgtgctctca aaacccacca     4980

gtcttgaaac gccatcaacg ggaaataact cgtactactc ttcagtcaga tcaagaggaa     5040

attgactatg atgataccat atcagttgaa atgaagaagg aagattttga catttatgat     5100

gaggatgaaa atcagagccc ccgcagcttt caaaagaaaa cacgacacta ttttattgct     5160

gcagtggaga ggctctggga ttatgggatg agtagctccc cacatgttct aagaaacagg     5220

gctcagagtg gcagtgtccc tcagttcaag aaagttgttt tccaggaatt tactgatggc     5280

tcctttactc agcccttata ccgtggagaa ctaaatgaac atttgggact cctggggcca     5340

tatataagag cagaagttga agataatatc atggtaactt tcagaaatca ggcctctcgt     5400

ccctattcct tctattctag ccttatttct tatgaggaag atcagaggca aggagcagaa     5460

cctagaaaaa actttgtcaa gcctaatgaa accaaaactt acttttggaa agtgcaacat     5520

catatggcac ccactaaaga tgagtttgac tgcaaagcct gggcttattt ctctgatgtt     5580

gacctggaaa aagatgtgca ctcaggcctg attggacccc ttctggtctg ccacactaac     5640

acactgaacc ctgctcatgg gagacaagtg acagtacagg aatttgctct gtttttcacc     5700

atctttgatg agaccaaaag ctggtacttc actgaaaata tggaaagaaa ctgcagggct     5760

ccctgcaata tccagatgga agatcccact tttaaagaga attatcgctt ccatgcaatc     5820

aatggctaca taatggatac actacctggc ttagtaatgg ctcaggatca aaggattcga     5880

tggtatctgc tcagcatggg cagcaatgaa aacatccatt ctattcattt cagtggacat     5940

gtgttcactg tacgaaaaaa agaggagtat aaaatggcac tgtacaatct ctatccaggt     6000

gtttttgaga cagtggaaat gttaccatcc aaagctggaa tttggcgggt ggaatgcctt     6060

attggcgagc atctacatgc tgggatgagc acactttttc tggtgtacag caataagtgt     6120

cagactcccc tgggaatggc ttctggacac attagagatt ttcagattac agcttcagga     6180

caatatggac agtgggcccc aaagctggcc agacttcatt attccggatc aatcaatgcc     6240

tggagcacca aggagccctt ttcttggatc aaggtggatc tgttggcacc aatgattatt     6300

cacggcatca agacccaggg tgcccgtcag aagttctcca gcctctacat ctctcagttt     6360

atcatcatgt atagtcttga tgggaagaag tggcagactt atcgaggaaa ttccactgga     6420

accttaatgg tcttctttgg caatgtggat tcatctggga taaaacacaa tatttttaac     6480

cctccaatta ttgctcgata catccgtttg cacccaactc attatagcat tcgcagcact     6540

cttcgcatgg agttgatggg ctgtgattta aatagttgca gcatgccatt gggaatggag     6600

agtaaagcaa tatcagatgc acagattact gcttcatcct actttaccaa tatgtttgcc     6660

acctggtctc cttcaaaagc tcgacttcac ctccaaggga ggagtaatgc ctggagacct     6720

caggtgaata atccaaaaga gtggctgcaa gtggacttcc agaagacaat gaaagtcaca     6780

ggagtaacta ctcagggagt aaaatctctg cttaccagca tgtatgtgaa ggagttcctc     6840

atctccagca gtcaagatgg ccatcagtgg actctctttt ttcagaatgg caaagtaaag     6900

gtttttcagg gaaatcaaga ctccttcaca cctgtggtga actctctaga cccaccgtta     6960

ctgactcgct accttcgaat tcacccccag agttgggtgc accagattgc cctgaggatg     7020

gaggttctgg gctgcgaggc acaggacctc tac                                  7053


<210>  108

<400>  108
000

<210>  109
<211>  1718
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BIVV001 BDD-FVIII(XTEN) Sequence (no Fc)

<400>  109

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Lys Arg Arg Leu Pro Lys Gly Val Lys His Leu 
                485                 490                 495     


Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr 
            500                 505                 510         


Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr 
        515                 520                 525             


Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly 
    530                 535                 540                 


Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg 
545                 550                 555                 560 


Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val 
                565                 570                 575     


Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe 
            580                 585                 590         


Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala 
        595                 600                 605             


Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln 
    610                 615                 620                 


Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile 
625                 630                 635                 640 


Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe 
                645                 650                 655     


Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser 
            660                 665                 670         


Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu 
        675                 680                 685             


Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu 
    690                 695                 700                 


Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser 
705                 710                 715                 720 


Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu 
                725                 730                 735     


Pro Arg Ser Phe Ser Gln Asn Gly Thr Ser Glu Ser Ala Thr Pro Glu 
            740                 745                 750         


Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 
        755                 760                 765             


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 
    770                 775                 780                 


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
785                 790                 795                 800 


Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
                805                 810                 815     


Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 
            820                 825                 830         


Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 
        835                 840                 845             


Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
    850                 855                 860                 


Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly 
865                 870                 875                 880 


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 
                885                 890                 895     


Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
            900                 905                 910         


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser 
        915                 920                 925             


Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 
    930                 935                 940                 


Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 
945                 950                 955                 960 


Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu 
                965                 970                 975     


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            980                 985                 990         


Ser Ala Pro Gly Ser Glu Pro Ala  Thr Ser Gly Ser Glu  Thr Pro Gly 
        995                 1000                 1005             


Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Gly Pro Gly  Thr Ser Thr 
    1010                 1015                 1020             


Glu Pro  Ser Glu Gly Ser Ala  Pro Ala Ser Ser Glu  Ile Thr Arg 
    1025                 1030                 1035             


Thr Thr  Leu Gln Ser Asp Gln  Glu Glu Ile Asp Tyr  Asp Asp Thr 
    1040                 1045                 1050             


Ile Ser  Val Glu Met Lys Lys  Glu Asp Phe Asp Ile  Tyr Asp Glu 
    1055                 1060                 1065             


Asp Glu  Asn Gln Ser Pro Arg  Ser Phe Gln Lys Lys  Thr Arg His 
    1070                 1075                 1080             


Tyr Phe  Ile Ala Ala Val Glu  Arg Leu Trp Asp Tyr  Gly Met Ser 
    1085                 1090                 1095             


Ser Ser  Pro His Val Leu Arg  Asn Arg Ala Gln Ser  Gly Ser Val 
    1100                 1105                 1110             


Pro Gln  Phe Lys Lys Val Val  Phe Gln Glu Phe Thr  Asp Gly Ser 
    1115                 1120                 1125             


Phe Thr  Gln Pro Leu Tyr Arg  Gly Glu Leu Asn Glu  His Leu Gly 
    1130                 1135                 1140             


Leu Leu  Gly Pro Tyr Ile Arg  Ala Glu Val Glu Asp  Asn Ile Met 
    1145                 1150                 1155             


Val Thr  Phe Arg Asn Gln Ala  Ser Arg Pro Tyr Ser  Phe Tyr Ser 
    1160                 1165                 1170             


Ser Leu  Ile Ser Tyr Glu Glu  Asp Gln Arg Gln Gly  Ala Glu Pro 
    1175                 1180                 1185             


Arg Lys  Asn Phe Val Lys Pro  Asn Glu Thr Lys Thr  Tyr Phe Trp 
    1190                 1195                 1200             


Lys Val  Gln His His Met Ala  Pro Thr Lys Asp Glu  Phe Asp Cys 
    1205                 1210                 1215             


Lys Ala  Trp Ala Tyr Phe Ser  Asp Val Asp Leu Glu  Lys Asp Val 
    1220                 1225                 1230             


His Ser  Gly Leu Ile Gly Pro  Leu Leu Val Cys His  Thr Asn Thr 
    1235                 1240                 1245             


Leu Asn  Pro Ala His Gly Arg  Gln Val Thr Val Gln  Glu Phe Ala 
    1250                 1255                 1260             


Leu Phe  Phe Thr Ile Phe Asp  Glu Thr Lys Ser Trp  Tyr Phe Thr 
    1265                 1270                 1275             


Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro Cys Asn  Ile Gln Met 
    1280                 1285                 1290             


Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg Phe His  Ala Ile Asn 
    1295                 1300                 1305             


Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu Val Met  Ala Gln Asp 
    1310                 1315                 1320             


Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met Gly Ser  Asn Glu Asn 
    1325                 1330                 1335             


Ile His  Ser Ile His Phe Ser  Gly His Val Phe Thr  Val Arg Lys 
    1340                 1345                 1350             


Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn Leu Tyr  Pro Gly Val 
    1355                 1360                 1365             


Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys Ala Gly  Ile Trp Arg 
    1370                 1375                 1380             


Val Glu  Cys Leu Ile Gly Glu  His Leu His Ala Gly  Met Ser Thr 
    1385                 1390                 1395             


Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln Thr Pro  Leu Gly Met 
    1400                 1405                 1410             


Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile Thr Ala  Ser Gly Gln 
    1415                 1420                 1425             


Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg Leu His  Tyr Ser Gly 
    1430                 1435                 1440             


Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro Phe Ser  Trp Ile Lys 
    1445                 1450                 1455             


Val Asp  Leu Leu Ala Pro Met  Ile Ile His Gly Ile  Lys Thr Gln 
    1460                 1465                 1470             


Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr Ile Ser  Gln Phe Ile 
    1475                 1480                 1485             


Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp Gln Thr  Tyr Arg Gly 
    1490                 1495                 1500             


Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe Gly Asn  Val Asp Ser 
    1505                 1510                 1515             


Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro Pro Ile  Ile Ala Arg 
    1520                 1525                 1530             


Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser Ile Arg  Ser Thr Leu 
    1535                 1540                 1545             


Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn Ser Cys  Ser Met Pro 
    1550                 1555                 1560             


Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp Ala Gln  Ile Thr Ala 
    1565                 1570                 1575             


Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr Trp Ser  Pro Ser Lys 
    1580                 1585                 1590             


Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn Ala Trp  Arg Pro Gln 
    1595                 1600                 1605             


Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val Asp Phe  Gln Lys Thr 
    1610                 1615                 1620             


Met Lys  Val Thr Gly Val Thr  Thr Gln Gly Val Lys  Ser Leu Leu 
    1625                 1630                 1635             


Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile Ser Ser  Ser Gln Asp 
    1640                 1645                 1650             


Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn Gly Lys  Val Lys Val 
    1655                 1660                 1665             


Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro Val Val  Asn Ser Leu 
    1670                 1675                 1680             


Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg Ile His  Pro Gln Ser 
    1685                 1690                 1695             


Trp Val  His Gln Ile Ala Leu  Arg Met Glu Val Leu  Gly Cys Glu 
    1700                 1705                 1710             


Ala Gln  Asp Leu Tyr 
    1715             


<210>  110
<211>  6526
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NB15.1v32 construct (AAV-FVIIIco6XTEN-ssDNA)

<400>  110
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggcaattc agtcgataac tataacggtc ctaaggtagc gatttaaata      180

cgcgctctct taaggtagcc ccgggacgcg tcaattgaga tctggatccg gtaccgaatt      240

cgcggccgcc tcgacgacta gcgtttaatt aaacgcgtgt ctgtctgcac atttcgtaga      300

gcgagtgttc cgatactcta atctccctag gcaaggttca tatttgtgta ggttacttat      360

tctccttttg ttgactaagt caataatcag aatcagcagg tttggagtca gcttggcagg      420

gatcagcagc ctgggttgga aggagggggt ataaaagccc cttcaccagg agaagccgtc      480

acacagatcc acaagctcct gaggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct      540

ttacgggtta tggcccttgc gtgccttgaa ttactgacac tgacatccac tttttctttt      600

tctccacagc tagcgccacc atgcagattg agctgtccac ttgtttcttc ctgtgcctcc      660

tgcgcttctg tttctccgcc actcgccggt actaccttgg agccgtggag ctttcatggg      720

actacatgca gagcgacctg ggcgaactcc ccgtggatgc cagattcccc ccccgcgtgc      780

caaagtcctt cccctttaac acctccgtgg tgtacaagaa aaccctcttt gtcgagttca      840

ctgaccacct gttcaacatc gccaagccgc gcccaccttg gatgggcctc ctgggaccga      900

ccattcaagc tgaagtgtac gacaccgtgg tgatcaccct gaagaacatg gcgtcccacc      960

ccgtgtccct gcatgcggtc ggagtgtcct actggaaggc ctccgaagga gctgagtacg     1020

acgaccagac tagccagcgg gaaaaggagg acgataaagt gttcccgggc ggctcgcata     1080

cttacgtgtg gcaagtcctg aaggaaaacg gacctatggc atccgatcct ctgtgcctga     1140

cttactccta cctttcccat gtggacctcg tgaaggacct gaacagcggg ctgattggtg     1200

cacttctcgt gtgccgcgaa ggttcgctcg ctaaggaaaa gacccagacc ctccataagt     1260

tcatcctttt gttcgctgtg ttcgatgaag gaaagtcatg gcattccgaa actaagaact     1320

cgctgatgca ggaccgggat gccgcctcag cccgcgcctg gcctaaaatg catacagtca     1380

acggatacgt gaatcggtca ctgcccgggc tcatcggttg tcacagaaag tccgtgtact     1440

ggcacgtcat cggcatgggc actacgcctg aagtgcactc catcttcctg gaagggcaca     1500

ccttcctcgt gcgcaaccac cgccaggcct ctctggaaat ctccccgatt acctttctga     1560

ccgcccagac tctgctcatg gacctggggc agttccttct cttctgccac atctccagcc     1620

atcagcacga cggaatggag gcctacgtga aggtggactc atgcccggaa gaacctcagt     1680

tgcggatgaa gaacaacgag gaggccgagg actatgacga cgatttgact gactccgaga     1740

tggacgtcgt gcggttcgat gacgacaaca gccccagctt catccagatt cgcagcgtgg     1800

ccaagaagca ccccaaaacc tgggtgcact acatcgcggc cgaggaagaa gattgggact     1860

acgccccgtt ggtgctggca cccgatgacc ggtcgtacaa gtcccagtat ctgaacaatg     1920

gtccgcagcg gattggcaga aagtacaaga aagtgcggtt catggcgtac actgacgaaa     1980

cgtttaagac ccgggaggcc attcaacatg agagcggcat tctgggacca ctgctgtacg     2040

gagaggtcgg cgataccctg ctcatcatct tcaaaaacca ggcctcccgg ccttacaaca     2100

tctaccctca cggaatcacc gacgtgcggc cactctactc gcggcgcctg ccgaagggcg     2160

tcaagcacct gaaagacttc cctatcctgc cgggcgaaat cttcaagtat aagtggaccg     2220

tcaccgtgga ggacgggccc accaagagcg atcctaggtg tctgactcgg tactactcca     2280

gcttcgtgaa catggaacgg gacctggcat cgggactcat tggaccgctg ctgatctgct     2340

acaaagagtc ggtggatcaa cgcggcaacc agatcatgtc cgacaagcgc aacgtgatcc     2400

tgttctccgt gtttgatgaa aacagatcct ggtacctcac tgaaaacatc cagaggttcc     2460

tcccaaaccc cgcaggagtg caactggagg accctgagtt tcaggcctcg aatatcatgc     2520

actcgattaa cggttacgtg ttcgactcgc tgcaactgag cgtgtgcctc catgaagtcg     2580

cttactggta cattctgtcc atcggcgccc agactgactt cctgagcgtg ttcttttccg     2640

gttacacctt taagcacaag atggtgtacg aagataccct gaccctgttc cctttctccg     2700

gcgaaacggt gttcatgtcg atggagaacc cgggtctgtg gattctggga tgccacaaca     2760

gcgactttcg gaaccgcgga atgactgccc tgctgaaggt gtcctcatgc gacaagaaca     2820

ccggagacta ctacgaggac tcctacgagg atatctcagc ctacctcctg tccaagaaca     2880

acgcgatcga gccgcgcagc ttcagccaga acggcgcgcc aacatcagag agcgccaccc     2940

ctgaaagtgg tcccgggagc gagccagcca catctgggtc ggaaacgcca ggcacaagtg     3000

agtctgcaac tcccgagtcc ggacctggct ccgagcctgc cactagcggc tccgagactc     3060

cgggaacttc cgagagcgct acaccagaaa gcggacccgg aaccagtacc gaacctagcg     3120

agggctctgc tccgggcagc ccagccggct ctcctacatc cacggaggag ggcacttccg     3180

aatccgccac cccggagtca gggccaggat ctgaacccgc tacctcaggc agtgagacgc     3240

caggaacgag cgagtccgct acaccggaga gtgggccagg gagccctgct ggatctccta     3300

cgtccactga ggaagggtca ccagcgggct cgcccaccag cactgaagaa ggtgcctcga     3360

gcccgcctgt gctgaagagg caccagcgag aaattacccg gaccaccctc caatcggatc     3420

aggaggaaat cgactacgac gacaccatct cggtggaaat gaagaaggaa gatttcgata     3480

tctacgacga ggacgaaaat cagtcccctc gctcattcca aaagaaaact agacactact     3540

ttatcgccgc ggtggaaaga ctgtgggact atggaatgtc atccagccct cacgtccttc     3600

ggaaccgggc ccagagcgga tcggtgcctc agttcaagaa agtggtgttc caggagttca     3660

ccgacggcag cttcacccag ccgctgtacc ggggagaact gaacgaacac ctgggcctgc     3720

tcggtcccta catccgcgcg gaagtggagg ataacatcat ggtgaccttc cgtaaccaag     3780

catccagacc ttactccttc tattcctccc tgatctcata cgaggaggac cagcgccaag     3840

gcgccgagcc ccgcaagaac ttcgtcaagc ccaacgagac taagacctac ttctggaagg     3900

tccaacacca tatggccccg accaaggatg agtttgactg caaggcctgg gcctacttct     3960

ccgacgtgga ccttgagaag gatgtccatt ccggcctgat cgggccgctg ctcgtgtgtc     4020

acaccaacac cctgaaccca gcgcatggac gccaggtcac cgtccaggag tttgctctgt     4080

tcttcaccat ttttgacgaa actaagtcct ggtacttcac cgagaatatg gagcgaaact     4140

gtagagcgcc ctgcaatatc cagatggaag atccgacttt caaggagaac tatagattcc     4200

acgccatcaa cgggtacatc atggatactc tgccggggct ggtcatggcc caggatcaga     4260

ggattcggtg gtacttgctg tcaatgggat cgaacgaaaa cattcactcc attcacttct     4320

ccggtcacgt gttcactgtg cgcaagaagg aggagtacaa gatggcgctg tacaatctgt     4380

accccggggt gttcgaaact gtggagatgc tgccgtccaa ggccggcatc tggagagtgg     4440

agtgcctgat cggagagcac ctccacgcgg ggatgtccac cctcttcctg gtgtactcga     4500

ataagtgcca gaccccgctg ggcatggcct cgggccacat cagagacttc cagatcacag     4560

caagcggaca atacggccaa tgggcgccga agctggcccg cttgcactac tccggatcga     4620

tcaacgcatg gtccaccaag gaaccgttct cgtggattaa ggtggacctc ctggccccta     4680

tgattatcca cggaattaag acccagggcg ccaggcagaa gttctcctcc ctgtacatct     4740

cgcaattcat catcatgtac agcctggacg ggaagaagtg gcagacttac aggggaaact     4800

ccaccggcac cctgatggtc tttttcggca acgtggattc ctccggcatt aagcacaaca     4860

tcttcaaccc accgatcata gccagatata ttaggctcca ccccactcac tactcaatcc     4920

gctcaactct tcggatggaa ctcatggggt gcgacctgaa ctcctgctcc atgccgttgg     4980

ggatggaatc aaaggctatt agcgacgccc agatcaccgc gagctcctac ttcactaaca     5040

tgttcgccac ctggagcccc tccaaggcca ggctgcactt gcagggacgg tcaaatgcct     5100

ggcggccgca agtgaacaat ccgaaggaat ggcttcaagt ggatttccaa aagaccatga     5160

aagtgaccgg agtcaccacc cagggagtga agtcccttct gacctcgatg tatgtgaagg     5220

agttcctgat tagcagcagc caggacgggc accagtggac cctgttcttc caaaacggaa     5280

aggtcaaggt gttccagggg aaccaggact cgttcacacc cgtggtgaac tccctggacc     5340

ccccactgct gacgcggtac ttgaggattc atcctcagtc ctgggtccat cagattgcat     5400

tgcgaatgga agtcctgggc tgcgaggccc aggacctgta ctgaatcagc ctgagctcgc     5460

tgatcataat caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta     5520

tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc     5580

ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga     5640

ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac     5700

ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc     5760

cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc     5820

tcggctgttg ggcactgaca attccgtggt gttgtcgggg aaatcatcgt cctttccttg     5880

gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc     5940

ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc     6000

gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct ccccgctgat     6060

cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt     6120

ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat     6180

cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg     6240

gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggcttctg     6300

aggcggaaag aacgggctcg agaagcttct agatatcctc tcttaaggta gcatcgagat     6360

ttaaattagg gataacaggg taatggcgcg ggccgcagga acccctagtg atggagttgg     6420

ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac     6480

gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcag                    6526


<210>  111
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'ITR (5'-end AAV2 inverted terminal repeat)

<400>  111
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  112
<211>  142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid Backbone Sequence (PBS)-1

<400>  112
gcggcaattc agtcgataac tataacggtc ctaaggtagc gatttaaata cgcgctctct       60

taaggtagcc ccgggacgcg tcaattgaga tctggatccg gtaccgaatt cgcggccgcc      120

tcgacgacta gcgtttaatt aa                                               142


<210>  113
<211>  229
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TTPp (liver-specific promoter)

<400>  113
acgcgtgtct gtctgcacat ttcgtagagc gagtgttccg atactctaat ctccctaggc       60

aaggttcata tttgtgtagg ttacttattc tccttttgtt gactaagtca ataatcagaa      120

tcagcaggtt tggagtcagc ttggcaggga tcagcagcct gggttggaag gagggggtat      180

aaaagcccct tcaccaggag aagccgtcac acagatccac aagctcctg                  229


<210>  114
<211>  2
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid Backbone Sequence (PBS)-2

<400>  114
ag                                                                       2


<210>  115
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Intron

<400>  115
gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg       60

ccttgaatta ctgacactga catccacttt ttctttttct ccacag                     106


<210>  116
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid Backbone Sequence (PBS)-3

<400>  116
ctagcgccac c                                                            11


<210>  117
<211>  4824
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIIIco6XTEN (open reading frame for codon-optimized FVIII 
       version 6 containing XTEN144)

<400>  117
atgcagattg agctgtccac ttgtttcttc ctgtgcctcc tgcgcttctg tttctccgcc       60

actcgccggt actaccttgg agccgtggag ctttcatggg actacatgca gagcgacctg      120

ggcgaactcc ccgtggatgc cagattcccc ccccgcgtgc caaagtcctt cccctttaac      180

acctccgtgg tgtacaagaa aaccctcttt gtcgagttca ctgaccacct gttcaacatc      240

gccaagccgc gcccaccttg gatgggcctc ctgggaccga ccattcaagc tgaagtgtac      300

gacaccgtgg tgatcaccct gaagaacatg gcgtcccacc ccgtgtccct gcatgcggtc      360

ggagtgtcct actggaaggc ctccgaagga gctgagtacg acgaccagac tagccagcgg      420

gaaaaggagg acgataaagt gttcccgggc ggctcgcata cttacgtgtg gcaagtcctg      480

aaggaaaacg gacctatggc atccgatcct ctgtgcctga cttactccta cctttcccat      540

gtggacctcg tgaaggacct gaacagcggg ctgattggtg cacttctcgt gtgccgcgaa      600

ggttcgctcg ctaaggaaaa gacccagacc ctccataagt tcatcctttt gttcgctgtg      660

ttcgatgaag gaaagtcatg gcattccgaa actaagaact cgctgatgca ggaccgggat      720

gccgcctcag cccgcgcctg gcctaaaatg catacagtca acggatacgt gaatcggtca      780

ctgcccgggc tcatcggttg tcacagaaag tccgtgtact ggcacgtcat cggcatgggc      840

actacgcctg aagtgcactc catcttcctg gaagggcaca ccttcctcgt gcgcaaccac      900

cgccaggcct ctctggaaat ctccccgatt acctttctga ccgcccagac tctgctcatg      960

gacctggggc agttccttct cttctgccac atctccagcc atcagcacga cggaatggag     1020

gcctacgtga aggtggactc atgcccggaa gaacctcagt tgcggatgaa gaacaacgag     1080

gaggccgagg actatgacga cgatttgact gactccgaga tggacgtcgt gcggttcgat     1140

gacgacaaca gccccagctt catccagatt cgcagcgtgg ccaagaagca ccccaaaacc     1200

tgggtgcact acatcgcggc cgaggaagaa gattgggact acgccccgtt ggtgctggca     1260

cccgatgacc ggtcgtacaa gtcccagtat ctgaacaatg gtccgcagcg gattggcaga     1320

aagtacaaga aagtgcggtt catggcgtac actgacgaaa cgtttaagac ccgggaggcc     1380

attcaacatg agagcggcat tctgggacca ctgctgtacg gagaggtcgg cgataccctg     1440

ctcatcatct tcaaaaacca ggcctcccgg ccttacaaca tctaccctca cggaatcacc     1500

gacgtgcggc cactctactc gcggcgcctg ccgaagggcg tcaagcacct gaaagacttc     1560

cctatcctgc cgggcgaaat cttcaagtat aagtggaccg tcaccgtgga ggacgggccc     1620

accaagagcg atcctaggtg tctgactcgg tactactcca gcttcgtgaa catggaacgg     1680

gacctggcat cgggactcat tggaccgctg ctgatctgct acaaagagtc ggtggatcaa     1740

cgcggcaacc agatcatgtc cgacaagcgc aacgtgatcc tgttctccgt gtttgatgaa     1800

aacagatcct ggtacctcac tgaaaacatc cagaggttcc tcccaaaccc cgcaggagtg     1860

caactggagg accctgagtt tcaggcctcg aatatcatgc actcgattaa cggttacgtg     1920

ttcgactcgc tgcaactgag cgtgtgcctc catgaagtcg cttactggta cattctgtcc     1980

atcggcgccc agactgactt cctgagcgtg ttcttttccg gttacacctt taagcacaag     2040

atggtgtacg aagataccct gaccctgttc cctttctccg gcgaaacggt gttcatgtcg     2100

atggagaacc cgggtctgtg gattctggga tgccacaaca gcgactttcg gaaccgcgga     2160

atgactgccc tgctgaaggt gtcctcatgc gacaagaaca ccggagacta ctacgaggac     2220

tcctacgagg atatctcagc ctacctcctg tccaagaaca acgcgatcga gccgcgcagc     2280

ttcagccaga acggcgcgcc aacatcagag agcgccaccc ctgaaagtgg tcccgggagc     2340

gagccagcca catctgggtc ggaaacgcca ggcacaagtg agtctgcaac tcccgagtcc     2400

ggacctggct ccgagcctgc cactagcggc tccgagactc cgggaacttc cgagagcgct     2460

acaccagaaa gcggacccgg aaccagtacc gaacctagcg agggctctgc tccgggcagc     2520

ccagccggct ctcctacatc cacggaggag ggcacttccg aatccgccac cccggagtca     2580

gggccaggat ctgaacccgc tacctcaggc agtgagacgc caggaacgag cgagtccgct     2640

acaccggaga gtgggccagg gagccctgct ggatctccta cgtccactga ggaagggtca     2700

ccagcgggct cgcccaccag cactgaagaa ggtgcctcga gcccgcctgt gctgaagagg     2760

caccagcgag aaattacccg gaccaccctc caatcggatc aggaggaaat cgactacgac     2820

gacaccatct cggtggaaat gaagaaggaa gatttcgata tctacgacga ggacgaaaat     2880

cagtcccctc gctcattcca aaagaaaact agacactact ttatcgccgc ggtggaaaga     2940

ctgtgggact atggaatgtc atccagccct cacgtccttc ggaaccgggc ccagagcgga     3000

tcggtgcctc agttcaagaa agtggtgttc caggagttca ccgacggcag cttcacccag     3060

ccgctgtacc ggggagaact gaacgaacac ctgggcctgc tcggtcccta catccgcgcg     3120

gaagtggagg ataacatcat ggtgaccttc cgtaaccaag catccagacc ttactccttc     3180

tattcctccc tgatctcata cgaggaggac cagcgccaag gcgccgagcc ccgcaagaac     3240

ttcgtcaagc ccaacgagac taagacctac ttctggaagg tccaacacca tatggccccg     3300

accaaggatg agtttgactg caaggcctgg gcctacttct ccgacgtgga ccttgagaag     3360

gatgtccatt ccggcctgat cgggccgctg ctcgtgtgtc acaccaacac cctgaaccca     3420

gcgcatggac gccaggtcac cgtccaggag tttgctctgt tcttcaccat ttttgacgaa     3480

actaagtcct ggtacttcac cgagaatatg gagcgaaact gtagagcgcc ctgcaatatc     3540

cagatggaag atccgacttt caaggagaac tatagattcc acgccatcaa cgggtacatc     3600

atggatactc tgccggggct ggtcatggcc caggatcaga ggattcggtg gtacttgctg     3660

tcaatgggat cgaacgaaaa cattcactcc attcacttct ccggtcacgt gttcactgtg     3720

cgcaagaagg aggagtacaa gatggcgctg tacaatctgt accccggggt gttcgaaact     3780

gtggagatgc tgccgtccaa ggccggcatc tggagagtgg agtgcctgat cggagagcac     3840

ctccacgcgg ggatgtccac cctcttcctg gtgtactcga ataagtgcca gaccccgctg     3900

ggcatggcct cgggccacat cagagacttc cagatcacag caagcggaca atacggccaa     3960

tgggcgccga agctggcccg cttgcactac tccggatcga tcaacgcatg gtccaccaag     4020

gaaccgttct cgtggattaa ggtggacctc ctggccccta tgattatcca cggaattaag     4080

acccagggcg ccaggcagaa gttctcctcc ctgtacatct cgcaattcat catcatgtac     4140

agcctggacg ggaagaagtg gcagacttac aggggaaact ccaccggcac cctgatggtc     4200

tttttcggca acgtggattc ctccggcatt aagcacaaca tcttcaaccc accgatcata     4260

gccagatata ttaggctcca ccccactcac tactcaatcc gctcaactct tcggatggaa     4320

ctcatggggt gcgacctgaa ctcctgctcc atgccgttgg ggatggaatc aaaggctatt     4380

agcgacgccc agatcaccgc gagctcctac ttcactaaca tgttcgccac ctggagcccc     4440

tccaaggcca ggctgcactt gcagggacgg tcaaatgcct ggcggccgca agtgaacaat     4500

ccgaaggaat ggcttcaagt ggatttccaa aagaccatga aagtgaccgg agtcaccacc     4560

cagggagtga agtcccttct gacctcgatg tatgtgaagg agttcctgat tagcagcagc     4620

caggacgggc accagtggac cctgttcttc caaaacggaa aggtcaaggt gttccagggg     4680

aaccaggact cgttcacacc cgtggtgaac tccctggacc ccccactgct gacgcggtac     4740

ttgaggattc atcctcagtc ctgggtccat cagattgcat tgcgaatgga agtcctgggc     4800

tgcgaggccc aggacctgta ctga                                            4824


<210>  118
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN144

<400>  118
ggcgcgccaa catcagagag cgccacccct gaaagtggtc ccgggagcga gccagccaca       60

tctgggtcgg aaacgccagg cacaagtgag tctgcaactc ccgagtccgg acctggctcc      120

gagcctgcca ctagcggctc cgagactccg ggaacttccg agagcgctac accagaaagc      180

ggacccggaa ccagtaccga acctagcgag ggctctgctc cgggcagccc agccggctct      240

cctacatcca cggaggaggg cacttccgaa tccgccaccc cggagtcagg gccaggatct      300

gaacccgcta cctcaggcag tgagacgcca ggaacgagcg agtccgctac accggagagt      360

gggccaggga gccctgctgg atctcctacg tccactgagg aagggtcacc agcgggctcg      420

cccaccagca ctgaagaagg tgcctcgagc                                       450


<210>  119
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid Backbone Sequence (PBS)-4

<400>  119
atcagcctga gctcgctga                                                    19


<210>  120
<211>  595
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPRE (mutated woodchuck hepatitis virus post-transcriptional 
       regulatory element)

<400>  120
tcataatcaa cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt       60

tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc      120

ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc tttatgagga      180

gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc      240

cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg ctttccccct      300

ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga caggggctcg      360

gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct      420

gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg tcccttcggc      480

cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg      540

tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc cgctg           595


<210>  121
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid Backbone Sequence (PBS)-5

<400>  121
atcagcct                                                                 8


<210>  122
<211>  211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bGHpA (bovine growth hormone polyadenylation signal)

<400>  122
cgactgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga       60

ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt      120

gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg      180

attgggaaga caatagcagg catgctgggg a                                     211


<210>  123
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid Backbone Sequence (PBS)-6

<400>  123
tgcggtgggc tctatggctt ctgaggcgga aagaacgggc tcgagaagct tctagatatc       60

ctctcttaag gtagcatcga gatttaaatt agggataaca gggtaatggc gcgggccgc       119


<210>  124
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3'ITR (3'-end AAV2 inverted terminal repeat)

<400>  124
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag                                                             130


<210>  125
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature FIX polypeptide

<400>  125

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              


Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  


Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  


Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      


Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         


Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             


Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 


Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 


Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     


Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         


Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             


Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 


Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 


Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     


His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         


Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             


Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 


Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 


Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     


Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         


Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             


His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 


Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 


Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
                405                 410                 415 


<210>  126
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature Padua(R338L)FIX Polypeptide

<400>  126

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              


Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  


Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  


Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      


Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         


Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             


Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 


Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 


Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     


Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         


Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             


Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 


Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 


Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     


His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         


Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             


Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 


Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 


Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     


Leu Leu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         


Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             


His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 


Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 


Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
                405                 410                 415 


<210>  127
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIX Signal Polypeptide and Propeptide

<400>  127

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg 
        35                  40                  45      


<210>  128
<211>  8442
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human VWF

<400>  128
atgattcctg ccagatttgc cggggtgctg cttgctctgg ccctcatttt gccagggacc       60

ctttgtgcag aaggaactcg cggcaggtca tccacggccc gatgcagcct tttcggaagt      120

gacttcgtca acacctttga tgggagcatg tacagctttg cgggatactg cagttacctc      180

ctggcagggg gctgccagaa acgctccttc tcgattattg gggacttcca gaatggcaag      240

agagtgagcc tctccgtgta tcttggggaa ttttttgaca tccatttgtt tgtcaatggt      300

accgtgacac agggggacca aagagtctcc atgccctatg cctccaaagg gctgtatcta      360

gaaactgagg ctgggtacta caagctgtcc ggtgaggcct atggctttgt ggccaggatc      420

gatggcagcg gcaactttca agtcctgctg tcagacagat acttcaacaa gacctgcggg      480

ctgtgtggca actttaacat ctttgctgaa gatgacttta tgacccaaga agggaccttg      540

acctcggacc cttatgactt tgccaactca tgggctctga gcagtggaga acagtggtgt      600

gaacgggcat ctcctcccag cagctcatgc aacatctcct ctggggaaat gcagaagggc      660

ctgtgggagc agtgccagct tctgaagagc acctcggtgt ttgcccgctg ccaccctctg      720

gtggaccccg agccttttgt ggccctgtgt gagaagactt tgtgtgagtg tgctgggggg      780

ctggagtgcg cctgccctgc cctcctggag tacgcccgga cctgtgccca ggagggaatg      840

gtgctgtacg gctggaccga ccacagcgcg tgcagcccag tgtgccctgc tggtatggag      900

tataggcagt gtgtgtcccc ttgcgccagg acctgccaga gcctgcacat caatgaaatg      960

tgtcaggagc gatgcgtgga tggctgcagc tgccctgagg gacagctcct ggatgaaggc     1020

ctctgcgtgg agagcaccga gtgtccctgc gtgcattccg gaaagcgcta ccctcccggc     1080

acctccctct ctcgagactg caacacctgc atttgccgaa acagccagtg gatctgcagc     1140

aatgaagaat gtccagggga gtgccttgtc actggtcaat cccacttcaa gagctttgac     1200

aacagatact tcaccttcag tgggatctgc cagtacctgc tggcccggga ttgccaggac     1260

cactccttct ccattgtcat tgagactgtc cagtgtgctg atgaccgcga cgctgtgtgc     1320

acccgctccg tcaccgtccg gctgcctggc ctgcacaaca gccttgtgaa actgaagcat     1380

ggggcaggag ttgccatgga tggccaggac atccagctcc ccctcctgaa aggtgacctc     1440

cgcatccagc atacagtgac ggcctccgtg cgcctcagct acggggagga cctgcagatg     1500

gactgggatg gccgcgggag gctgctggtg aagctgtccc ccgtctatgc cgggaagacc     1560

tgcggcctgt gtgggaatta caatggcaac cagggcgacg acttccttac cccctctggg     1620

ctggcrgagc cccgggtgga ggacttcggg aacgcctgga agctgcacgg ggactgccag     1680

gacctgcaga agcagcacag cgatccctgc gccctcaacc cgcgcatgac caggttctcc     1740

gaggaggcgt gcgcggtcct gacgtccccc acattcgagg cctgccatcg tgccgtcagc     1800

ccgctgccct acctgcggaa ctgccgctac gacgtgtgct cctgctcgga cggccgcgag     1860

tgcctgtgcg gcgccctggc cagctatgcc gcggcctgcg cggggagagg cgtgcgcgtc     1920

gcgtggcgcg agccaggccg ctgtgagctg aactgcccga aaggccaggt gtacctgcag     1980

tgcgggaccc cctgcaacct gacctgccgc tctctctctt acccggatga ggaatgcaat     2040

gaggcctgcc tggagggctg cttctgcccc ccagggctct acatggatga gaggggggac     2100

tgcgtgccca aggcccagtg cccctgttac tatgacggtg agatcttcca gccagaagac     2160

atcttctcag accatcacac catgtgctac tgtgaggatg gcttcatgca ctgtaccatg     2220

agtggagtcc ccggaagctt gctgcctgac gctgtcctca gcagtcccct gtctcatcgc     2280

agcaaaagga gcctatcctg tcggcccccc atggtcaagc tggtgtgtcc cgctgacaac     2340

ctgcgggctg aagggctcga gtgtaccaaa acgtgccaga actatgacct ggagtgcatg     2400

agcatgggct gtgtctctgg ctgcctctgc cccccgggca tggtccggca tgagaacaga     2460

tgtgtggccc tggaaaggtg tccctgcttc catcagggca aggagtatgc ccctggagaa     2520

acagtgaaga ttggctgcaa cacttgtgtc tgtcgggacc ggaagtggaa ctgcacagac     2580

catgtgtgtg atgccacgtg ctccacgatc ggcatggccc actacctcac cttcgacggg     2640

ctcaaatacc tgttccccgg ggagtgccag tacgttctgg tgcaggatta ctgcggcagt     2700

aaccctggga cctttcggat cctagtgggg aataagggat gcagccaccc ctcagtgaaa     2760

tgcaagaaac gggtcaccat cctggtggag ggaggagaga ttgagctgtt tgacggggag     2820

gtgaatgtga agaggcccat gaaggatgag actcactttg aggtggtgga gtctggccgg     2880

tacatcattc tgctgctggg caaagccctc tccgtggtct gggaccgcca cctgagcatc     2940

tccgtggtcc tgaagcagac ataccaggag aaagtgtgtg gcctgtgtgg gaattttgat     3000

ggcatccaga acaatgacct caccagcagc aacctccaag tggaggaaga ccctgtggac     3060

tttgggaact cctggaaagt gagctcgcag tgtgctgaca ccagaaaagt gcctctggac     3120

tcatcccctg ccacctgcca taacaacatc atgaagcaga cgatggtgga ttcctcctgt     3180

agaatcctta ccagtgacgt cttccaggac tgcaacaagc tggtggaccc cgagccatat     3240

ctggatgtct gcatttacga cacctgctcc tgtgagtcca ttggggactg cgcctgcttc     3300

tgcgacacca ttgctgccta tgcccacgtg tgtgcccagc atggcaaggt ggtgacctgg     3360

aggacggcca cattgtgccc ccagagctgc gaggagagga atctccggga gaacgggtat     3420

gagtgtgagt ggcgctataa cagctgtgca cctgcctgtc aagtcacgtg tcagcaccct     3480

gagccactgg cctgccctgt gcagtgtgtg gagggctgcc atgcccactg ccctccaggg     3540

aaaatcctgg atgagctttt gcagacctgc gttgaccctg aagactgtcc agtgtgtgag     3600

gtggctggcc ggcgttttgc ctcaggaaag aaagtcacct tgaatcccag tgaccctgag     3660

cactgccaga tttgccactg tgatgttgtc aacctcacct gtgaagcctg ccaggagccg     3720

ggaggcctgg tggtgcctcc cacagatgcc ccggtgagcc ccaccactct gtatgtggag     3780

gacatctcgg aaccgccgtt gcacgatttc tactgcagca ggctactgga cctggtcttc     3840

ctgctggatg gctcctccag gctgtccgag gctgagtttg aagtgctgaa ggcctttgtg     3900

gtggacatga tggagcggct gcgcatctcc cagaagtggg tccgcgtggc cgtggtggag     3960

taccacgacg gctcccacgc ctacatcggg ctcaaggacc ggaagcgacc gtcagagctg     4020

cggcgcattg ccagccaggt gaagtatgcg ggcagccagg tggcctccac cagcgaggtc     4080

ttgaaataca cactgttcca aatcttcagc aagatcgacc gccctgaagc ctcccgcatc     4140

gccctgctcc tgatggccag ccaggagccc caacggatgt cccggaactt tgtccgctac     4200

gtccagggcc tgaagaagaa gaaggtcatt gtgatcccgg tgggcattgg gccccatgcc     4260

aacctcaagc agatccgcct catcgagaag caggcccctg agaacaaggc cttcgtgctg     4320

agcagtgtgg atgagctgga gcagcaaagg gacgagatcg ttagctacct ctgtgacctt     4380

gcccctgaag cccctcctcc tactctgccc cccgacatgg cacaagtcac tgtgggcccg     4440

gggctcttgg gggtttcgac cctggggccc aagaggaact ccatggttct ggatgtggcg     4500

ttcgtcctgg aaggatcgga caaaattggt gaagccgact tcaacaggag caaggagttc     4560

atggaggagg tgattcagcg gatggatgtg ggccaggaca gcatccacgt cacggtgctg     4620

cagtactcct acatggtgac cgtggagtac cccttcagcg aggcacagtc caaaggggac     4680

atcctgcagc gggtgcgaga gatccgctac cagggcggca acaggaccaa cactgggctg     4740

gccctgcggt acctctctga ccacagcttc ttggtcagcc agggtgaccg ggagcaggcg     4800

cccaacctgg tctacatggt caccggaaat cctgcctctg atgagatcaa gaggctgcct     4860

ggagacatcc aggtggtgcc cattggagtg ggccctaatg ccaacgtgca ggagctggag     4920

aggattggct ggcccaatgc ccctatcctc atccaggact ttgagacgct cccccgagag     4980

gctcctgacc tggtgctgca gaggtgctgc tccggagagg ggctgcagat ccccaccctc     5040

tcccctgcac ctgactgcag ccagcccctg gacgtgatcc ttctcctgga tggctcctcc     5100

agtttcccag cttcttattt tgatgaaatg aagagtttcg ccaaggcttt catttcaaaa     5160

gccaatatag ggcctcgtct cactcaggtg tcagtgctgc agtatggaag catcaccacc     5220

attgacgtgc catggaacgt ggtcccggag aaagcccatt tgctgagcct tgtggacgtc     5280

atgcagcggg agggaggccc cagccaaatc ggggatgcct tgggctttgc tgtgcgatac     5340

ttgacttcag aaatgcatgg tgccaggccg ggagcctcaa aggcggtggt catcctggtc     5400

acggacgtct ctgtggattc agtggatgca gcagctgatg ccgccaggtc caacagagtg     5460

acagtgttcc ctattggaat tggagatcgc tacgatgcag cccagctacg gatcttggca     5520

ggcccagcag gcgactccaa cgtggtgaag ctccagcgaa tcgaagacct ccctaccatg     5580

gtcaccttgg gcaattcctt cctccacaaa ctgtgctctg gatttgttag gatttgcatg     5640

gatgaggatg ggaatgagaa gaggcccggg gacgtctgga ccttgccaga ccagtgccac     5700

accgtgactt gccagccaga tggccagacc ttgctgaaga gtcatcgggt caactgtgac     5760

cgggggctga ggccttcgtg ccctaacagc cagtcccctg ttaaagtgga agagacctgt     5820

ggctgccgct ggacctgccc ctgygtgtgc acaggcagct ccactcggca catcgtgacc     5880

tttgatgggc agaatttcaa gctgactggc agctgttctt atgtcctatt tcaaaacaag     5940

gagcaggacc tggaggtgat tctccataat ggtgcctgca gccctggagc aaggcagggc     6000

tgcatgaaat ccatcgaggt gaagcacagt gccctctccg tcgagstgca cagtgacatg     6060

gaggtgacgg tgaatgggag actggtctct gttccttacg tgggtgggaa catggaagtc     6120

aacgtttatg gtgccatcat gcatgaggtc agattcaatc accttggtca catcttcaca     6180

ttcactccac aaaacaatga gttccaactg cagctcagcc ccaagacttt tgcttcaaag     6240

acgtatggtc tgtgtgggat ctgtgatgag aacggagcca atgacttcat gctgagggat     6300

ggcacagtca ccacagactg gaaaacactt gttcaggaat ggactgtgca gcggccaggg     6360

cagacgtgcc agcccatcct ggaggagcag tgtcttgtcc ccgacagctc ccactgccag     6420

gtcctcctct taccactgtt tgctgaatgc cacaaggtcc tggctccagc cacattctat     6480

gccatctgcc agcaggacag ttgccaccag gagcaagtgt gtgaggtgat cgcctcttat     6540

gcccacctct gtcggaccaa cggggtctgc gttgactgga ggacacctga tttctgtgct     6600

atgtcatgcc caccatctct ggtctacaac cactgtgagc atggctgtcc ccggcactgt     6660

gatggcaacg tgagctcctg tggggaccat ccctccgaag gctgtttctg ccctccagat     6720

aaagtcatgt tggaaggcag ctgtgtccct gaagaggcct gcactcagtg cattggtgag     6780

gatggagtcc agcaccagtt cctggaagcc tgggtcccgg accaccagcc ctgtcagatc     6840

tgcacatgcc tcagcgggcg gaaggtcaac tgcacaacgc agccctgccc cacggccaaa     6900

gctcccacgt gtggcctgtg tgaagtagcc cgcctccgcc agaatgcaga ccagtgctgc     6960

cccgagtatg agtgtgtgtg tgacccagtg agctgtgacc tgcccccagt gcctcactgt     7020

gaacgtggcc tccagcccac actgaccaac cctggcgagt gcagacccaa cttcacctgc     7080

gcctgcagga aggaggagtg caaaagagtg tccccaccct cctgcccccc gcaccgtttg     7140

cccacccttc ggaagaccca gtgctgtgat gagtatgagt gtgcctgcaa ctgtgtcaac     7200

tccacagtga gctgtcccct tgggtacttg gcctcaaccg ccaccaatga ctgtggctgt     7260

accacaacca cctgccttcc cgacaaggtg tgtgtccacc gaagcaccat ctaccctgtg     7320

ggccagttct gggaggaggg ctgcgatgtg tgcacctgca ccgacatgga ggatgccgtg     7380

atgggcctcc gcgtggccca gtgctcccag aagccctgtg aggacagctg tcggtcgggc     7440

ttcacttacg ttctgcatga aggcgagtgc tgtggaaggt gcctgccatc tgcctgtgag     7500

gtggtgactg gctcaccgcg gggggactcc cagtcttcct ggaagagtgt cggctcccag     7560

tgggcctccc cggagaaccc ctgcctcatc aatgagtgtg tccgagtgaa ggaggaggtc     7620

tttatacaac aaaggaacgt ctcctgcccc cagctggagg tccctgtctg cccctcgggc     7680

tttcagctga gctgtaagac ctcagcgtgc tgcccaagct gtcgctgtga gcgcatggag     7740

gcctgcatgc tcaatggcac tgtcattggg cccgggaaga ctgtgatgat cgatgtgtgc     7800

acgacctgcc gctgcatggt gcaggtgggg gtcatctctg gattcaagct ggagtgcagg     7860

aagaccacct gcaacccctg ccccctgggt tacaaggaag aaaataacac aggtgaatgt     7920

tgtgggagat gtttgcctac ggcttgcacc attcagctaa gaggaggaca gatcatgaca     7980

ctgaagcgtg atgagacgct ccaggatggc tgtgatactc acttctgcaa ggtcaatgag     8040

agaggagagt acttctggga gaagagggtc acaggctgcc caccctttga tgaacacaag     8100

tgtcttgctg agggaggtaa aattatgaaa attccaggca cctgctgtga cacatgtgag     8160

gagcctgagt gcaacgacat cactgccagg ctgcagtatg tcaaggtggg aagctgtaag     8220

tctgaagtag aggtggatat ccactactgc cagggcaaat gtgccagcaa agccatgtac     8280

tccattgaca tcaacgatgt gcaggaccag tgctcctgct gctctccgac acggacggag     8340

cccatgcagg tggccctgca ctgcaccaat ggctctgttg tgtaccatga ggttctcaat     8400

gccatggagt gcaaatgctc ccccaggaag tgcagcaagt ga                        8442


<210>  129
<211>  2809
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human VWF


<220>
<221>  misc_feature
<222>  (540)..(540)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1944)..(1944)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (2012)..(2012)
<223>  Xaa can be any naturally occurring amino acid

<400>  129

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Cys Glu Lys Thr Leu Cys Glu Cys Ala 
                245                 250                 255     


Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala Arg Thr 
            260                 265                 270         


Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His Ser Ala 
        275                 280                 285             


Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys Val Ser 
    290                 295                 300                 


Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met Cys Gln 
305                 310                 315                 320 


Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu Leu Asp 
                325                 330                 335     


Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His Ser Gly 
            340                 345                 350         


Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn Thr Cys 
        355                 360                 365             


Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys Pro Gly 
    370                 375                 380                 


Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp Asn Arg 
385                 390                 395                 400 


Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg Asp Cys 
                405                 410                 415     


Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys Ala Asp 
            420                 425                 430         


Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu Pro Gly 
        435                 440                 445             


Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val Ala Met 
    450                 455                 460                 


Asp Gly Gln Asp Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu Arg Ile 
465                 470                 475                 480 


Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu Asp Leu 
                485                 490                 495     


Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu Ser Pro 
            500                 505                 510         


Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn Gly Asn 
        515                 520                 525             


Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Xaa Glu Pro Arg Val 
    530                 535                 540                 


Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln Asp Leu 
545                 550                 555                 560 


Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met Thr Arg 
                565                 570                 575     


Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe Glu Ala 
            580                 585                 590         


Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys Arg Tyr 
        595                 600                 605             


Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly Ala Ser 
    610                 615                 620                 


Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val Ala Trp Arg Glu 
625                 630                 635                 640 


Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln Val Tyr Leu Gln 
                645                 650                 655     


Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu Ser Tyr Pro Asp 
            660                 665                 670         


Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe Cys Pro Pro Gly 
        675                 680                 685             


Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys Ala Gln Cys Pro 
    690                 695                 700                 


Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp Ile Phe Ser Asp 
705                 710                 715                 720 


His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met His Cys Thr Met 
                725                 730                 735     


Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val Leu Ser Ser Pro 
            740                 745                 750         


Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg Pro Pro Met Val 
        755                 760                 765             


Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys 
    770                 775                 780                 


Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met Ser Met Gly Cys 
785                 790                 795                 800 


Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg His Glu Asn Arg 
                805                 810                 815     


Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly Lys Glu Tyr 
            820                 825                 830         


Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr Cys Val Cys Arg 
        835                 840                 845             


Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala Thr Cys Ser 
    850                 855                 860                 


Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly Leu Lys Tyr Leu 
865                 870                 875                 880 


Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr Cys Gly Ser 
                885                 890                 895     


Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys Ser His 
            900                 905                 910         


Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu Val Glu Gly Gly 
        915                 920                 925             


Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys Arg Pro Met Lys 
    930                 935                 940                 


Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr Ile Ile Leu 
945                 950                 955                 960 


Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg His Leu Ser Ile 
                965                 970                 975     


Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val Cys Gly Leu Cys 
            980                 985                 990         


Gly Asn Phe Asp Gly Ile Gln Asn  Asn Asp Leu Thr Ser  Ser Asn Leu 
        995                 1000                 1005             


Gln Val  Glu Glu Asp Pro Val  Asp Phe Gly Asn Ser  Trp Lys Val 
    1010                 1015                 1020             


Ser Ser  Gln Cys Ala Asp Thr  Arg Lys Val Pro Leu  Asp Ser Ser 
    1025                 1030                 1035             


Pro Ala  Thr Cys His Asn Asn  Ile Met Lys Gln Thr  Met Val Asp 
    1040                 1045                 1050             


Ser Ser  Cys Arg Ile Leu Thr  Ser Asp Val Phe Gln  Asp Cys Asn 
    1055                 1060                 1065             


Lys Leu  Val Asp Pro Glu Pro  Tyr Leu Asp Val Cys  Ile Tyr Asp 
    1070                 1075                 1080             


Thr Cys  Ser Cys Glu Ser Ile  Gly Asp Cys Ala Cys  Phe Cys Asp 
    1085                 1090                 1095             


Thr Ile  Ala Ala Tyr Ala His  Val Cys Ala Gln His  Gly Lys Val 
    1100                 1105                 1110             


Val Thr  Trp Arg Thr Ala Thr  Leu Cys Pro Gln Ser  Cys Glu Glu 
    1115                 1120                 1125             


Arg Asn  Leu Arg Glu Asn Gly  Tyr Glu Cys Glu Trp  Arg Tyr Asn 
    1130                 1135                 1140             


Ser Cys  Ala Pro Ala Cys Gln  Val Thr Cys Gln His  Pro Glu Pro 
    1145                 1150                 1155             


Leu Ala  Cys Pro Val Gln Cys  Val Glu Gly Cys His  Ala His Cys 
    1160                 1165                 1170             


Pro Pro  Gly Lys Ile Leu Asp  Glu Leu Leu Gln Thr  Cys Val Asp 
    1175                 1180                 1185             


Pro Glu  Asp Cys Pro Val Cys  Glu Val Ala Gly Arg  Arg Phe Ala 
    1190                 1195                 1200             


Ser Gly  Lys Lys Val Thr Leu  Asn Pro Ser Asp Pro  Glu His Cys 
    1205                 1210                 1215             


Gln Ile  Cys His Cys Asp Val  Val Asn Leu Thr Cys  Glu Ala Cys 
    1220                 1225                 1230             


Gln Glu  Pro Gly Gly Leu Val  Val Pro Pro Thr Asp  Ala Pro Val 
    1235                 1240                 1245             


Ser Pro  Thr Thr Leu Tyr Val  Glu Asp Ile Ser Glu  Pro Pro Leu 
    1250                 1255                 1260             


His Asp  Phe Tyr Cys Ser Arg  Leu Leu Asp Leu Val  Phe Leu Leu 
    1265                 1270                 1275             


Asp Gly  Ser Ser Arg Leu Ser  Glu Ala Glu Phe Glu  Val Leu Lys 
    1280                 1285                 1290             


Ala Phe  Val Val Asp Met Met  Glu Arg Leu Arg Ile  Ser Gln Lys 
    1295                 1300                 1305             


Trp Val  Arg Val Ala Val Val  Glu Tyr His Asp Gly  Ser His Ala 
    1310                 1315                 1320             


Tyr Ile  Gly Leu Lys Asp Arg  Lys Arg Pro Ser Glu  Leu Arg Arg 
    1325                 1330                 1335             


Ile Ala  Ser Gln Val Lys Tyr  Ala Gly Ser Gln Val  Ala Ser Thr 
    1340                 1345                 1350             


Ser Glu  Val Leu Lys Tyr Thr  Leu Phe Gln Ile Phe  Ser Lys Ile 
    1355                 1360                 1365             


Asp Arg  Pro Glu Ala Ser Arg  Ile Ala Leu Leu Leu  Met Ala Ser 
    1370                 1375                 1380             


Gln Glu  Pro Gln Arg Met Ser  Arg Asn Phe Val Arg  Tyr Val Gln 
    1385                 1390                 1395             


Gly Leu  Lys Lys Lys Lys Val  Ile Val Ile Pro Val  Gly Ile Gly 
    1400                 1405                 1410             


Pro His  Ala Asn Leu Lys Gln  Ile Arg Leu Ile Glu  Lys Gln Ala 
    1415                 1420                 1425             


Pro Glu  Asn Lys Ala Phe Val  Leu Ser Ser Val Asp  Glu Leu Glu 
    1430                 1435                 1440             


Gln Gln  Arg Asp Glu Ile Val  Ser Tyr Leu Cys Asp  Leu Ala Pro 
    1445                 1450                 1455             


Glu Ala  Pro Pro Pro Thr Leu  Pro Pro Asp Met Ala  Gln Val Thr 
    1460                 1465                 1470             


Val Gly  Pro Gly Leu Leu Gly  Val Ser Thr Leu Gly  Pro Lys Arg 
    1475                 1480                 1485             


Asn Ser  Met Val Leu Asp Val  Ala Phe Val Leu Glu  Gly Ser Asp 
    1490                 1495                 1500             


Lys Ile  Gly Glu Ala Asp Phe  Asn Arg Ser Lys Glu  Phe Met Glu 
    1505                 1510                 1515             


Glu Val  Ile Gln Arg Met Asp  Val Gly Gln Asp Ser  Ile His Val 
    1520                 1525                 1530             


Thr Val  Leu Gln Tyr Ser Tyr  Met Val Thr Val Glu  Tyr Pro Phe 
    1535                 1540                 1545             


Ser Glu  Ala Gln Ser Lys Gly  Asp Ile Leu Gln Arg  Val Arg Glu 
    1550                 1555                 1560             


Ile Arg  Tyr Gln Gly Gly Asn  Arg Thr Asn Thr Gly  Leu Ala Leu 
    1565                 1570                 1575             


Arg Tyr  Leu Ser Asp His Ser  Phe Leu Val Ser Gln  Gly Asp Arg 
    1580                 1585                 1590             


Glu Gln  Ala Pro Asn Leu Val  Tyr Met Val Thr Gly  Asn Pro Ala 
    1595                 1600                 1605             


Ser Asp  Glu Ile Lys Arg Leu  Pro Gly Asp Ile Gln  Val Val Pro 
    1610                 1615                 1620             


Ile Gly  Val Gly Pro Asn Ala  Asn Val Gln Glu Leu  Glu Arg Ile 
    1625                 1630                 1635             


Gly Trp  Pro Asn Ala Pro Ile  Leu Ile Gln Asp Phe  Glu Thr Leu 
    1640                 1645                 1650             


Pro Arg  Glu Ala Pro Asp Leu  Val Leu Gln Arg Cys  Cys Ser Gly 
    1655                 1660                 1665             


Glu Gly  Leu Gln Ile Pro Thr  Leu Ser Pro Ala Pro  Asp Cys Ser 
    1670                 1675                 1680             


Gln Pro  Leu Asp Val Ile Leu  Leu Leu Asp Gly Ser  Ser Ser Phe 
    1685                 1690                 1695             


Pro Ala  Ser Tyr Phe Asp Glu  Met Lys Ser Phe Ala  Lys Ala Phe 
    1700                 1705                 1710             


Ile Ser  Lys Ala Asn Ile Gly  Pro Arg Leu Thr Gln  Val Ser Val 
    1715                 1720                 1725             


Leu Gln  Tyr Gly Ser Ile Thr  Thr Ile Asp Val Pro  Trp Asn Val 
    1730                 1735                 1740             


Val Pro  Glu Lys Ala His Leu  Leu Ser Leu Val Asp  Val Met Gln 
    1745                 1750                 1755             


Arg Glu  Gly Gly Pro Ser Gln  Ile Gly Asp Ala Leu  Gly Phe Ala 
    1760                 1765                 1770             


Val Arg  Tyr Leu Thr Ser Glu  Met His Gly Ala Arg  Pro Gly Ala 
    1775                 1780                 1785             


Ser Lys  Ala Val Val Ile Leu  Val Thr Asp Val Ser  Val Asp Ser 
    1790                 1795                 1800             


Val Asp  Ala Ala Ala Asp Ala  Ala Arg Ser Asn Arg  Val Thr Val 
    1805                 1810                 1815             


Phe Pro  Ile Gly Ile Gly Asp  Arg Tyr Asp Ala Ala  Gln Leu Arg 
    1820                 1825                 1830             


Ile Leu  Ala Gly Pro Ala Gly  Asp Ser Asn Val Val  Lys Leu Gln 
    1835                 1840                 1845             


Arg Ile  Glu Asp Leu Pro Thr  Met Val Thr Leu Gly  Asn Ser Phe 
    1850                 1855                 1860             


Leu His  Lys Leu Cys Ser Gly  Phe Val Arg Ile Cys  Met Asp Glu 
    1865                 1870                 1875             


Asp Gly  Asn Glu Lys Arg Pro  Gly Asp Val Trp Thr  Leu Pro Asp 
    1880                 1885                 1890             


Gln Cys  His Thr Val Thr Cys  Gln Pro Asp Gly Gln  Thr Leu Leu 
    1895                 1900                 1905             


Lys Ser  His Arg Val Asn Cys  Asp Arg Gly Leu Arg  Pro Ser Cys 
    1910                 1915                 1920             


Pro Asn  Ser Gln Ser Pro Val  Lys Val Glu Glu Thr  Cys Gly Cys 
    1925                 1930                 1935             


Arg Trp  Thr Cys Pro Xaa Val  Cys Thr Gly Ser Ser  Thr Arg His 
    1940                 1945                 1950             


Ile Val  Thr Phe Asp Gly Gln  Asn Phe Lys Leu Thr  Gly Ser Cys 
    1955                 1960                 1965             


Ser Tyr  Val Leu Phe Gln Asn  Lys Glu Gln Asp Leu  Glu Val Ile 
    1970                 1975                 1980             


Leu His  Asn Gly Ala Cys Ser  Pro Gly Ala Arg Gln  Gly Cys Met 
    1985                 1990                 1995             


Lys Ser  Ile Glu Val Lys His  Ser Ala Leu Ser Val  Glu Xaa His 
    2000                 2005                 2010             


Ser Asp  Met Glu Val Thr Val  Asn Gly Arg Leu Val  Ser Val Pro 
    2015                 2020                 2025             


Tyr Val  Gly Gly Asn Met Glu  Val Asn Val Tyr Gly  Ala Ile Met 
    2030                 2035                 2040             


His Glu  Val Arg Phe Asn His  Leu Gly His Ile Phe  Thr Phe Thr 
    2045                 2050                 2055             


Pro Gln  Asn Asn Glu Phe Gln  Leu Gln Leu Ser Pro  Lys Thr Phe 
    2060                 2065                 2070             


Ala Ser  Lys Thr Tyr Gly Leu  Cys Gly Ile Cys Asp  Glu Asn Gly 
    2075                 2080                 2085             


Ala Asn  Asp Phe Met Leu Arg  Asp Gly Thr Val Thr  Thr Asp Trp 
    2090                 2095                 2100             


Lys Thr  Leu Val Gln Glu Trp  Thr Val Gln Arg Pro  Gly Gln Thr 
    2105                 2110                 2115             


Cys Gln  Pro Ile Leu Glu Glu  Gln Cys Leu Val Pro  Asp Ser Ser 
    2120                 2125                 2130             


His Cys  Gln Val Leu Leu Leu  Pro Leu Phe Ala Glu  Cys His Lys 
    2135                 2140                 2145             


Val Leu  Ala Pro Ala Thr Phe  Tyr Ala Ile Cys Gln  Gln Asp Ser 
    2150                 2155                 2160             


Cys His  Gln Glu Gln Val Cys  Glu Val Ile Ala Ser  Tyr Ala His 
    2165                 2170                 2175             


Leu Cys  Arg Thr Asn Gly Val  Cys Val Asp Trp Arg  Thr Pro Asp 
    2180                 2185                 2190             


Phe Cys  Ala Met Ser Cys Pro  Pro Ser Leu Val Tyr  Asn His Cys 
    2195                 2200                 2205             


Glu His  Gly Cys Pro Arg His  Cys Asp Gly Asn Val  Ser Ser Cys 
    2210                 2215                 2220             


Gly Asp  His Pro Ser Glu Gly  Cys Phe Cys Pro Pro  Asp Lys Val 
    2225                 2230                 2235             


Met Leu  Glu Gly Ser Cys Val  Pro Glu Glu Ala Cys  Thr Gln Cys 
    2240                 2245                 2250             


Ile Gly  Glu Asp Gly Val Gln  His Gln Phe Leu Glu  Ala Trp Val 
    2255                 2260                 2265             


Pro Asp  His Gln Pro Cys Gln  Ile Cys Thr Cys Leu  Ser Gly Arg 
    2270                 2275                 2280             


Lys Val  Asn Cys Thr Thr Gln  Pro Cys Pro Thr Ala  Lys Ala Pro 
    2285                 2290                 2295             


Thr Cys  Gly Leu Cys Glu Val  Ala Arg Leu Arg Gln  Asn Ala Asp 
    2300                 2305                 2310             


Gln Cys  Cys Pro Glu Tyr Glu  Cys Val Cys Asp Pro  Val Ser Cys 
    2315                 2320                 2325             


Asp Leu  Pro Pro Val Pro His  Cys Glu Arg Gly Leu  Gln Pro Thr 
    2330                 2335                 2340             


Leu Thr  Asn Pro Gly Glu Cys  Arg Pro Asn Phe Thr  Cys Ala Cys 
    2345                 2350                 2355             


Arg Lys  Glu Glu Cys Lys Arg  Val Ser Pro Pro Ser  Cys Pro Pro 
    2360                 2365                 2370             


His Arg  Leu Pro Thr Leu Arg  Lys Thr Gln Cys Cys  Asp Glu Tyr 
    2375                 2380                 2385             


Glu Cys  Ala Cys Asn Cys Val  Asn Ser Thr Val Ser  Cys Pro Leu 
    2390                 2395                 2400             


Gly Tyr  Leu Ala Ser Thr Ala  Thr Asn Asp Cys Gly  Cys Thr Thr 
    2405                 2410                 2415             


Thr Thr  Cys Leu Pro Asp Lys  Val Cys Val His Arg  Ser Thr Ile 
    2420                 2425                 2430             


Tyr Pro  Val Gly Gln Phe Trp  Glu Glu Gly Cys Asp  Val Cys Thr 
    2435                 2440                 2445             


Cys Thr  Asp Met Glu Asp Ala  Val Met Gly Leu Arg  Val Ala Gln 
    2450                 2455                 2460             


Cys Ser  Gln Lys Pro Cys Glu  Asp Ser Cys Arg Ser  Gly Phe Thr 
    2465                 2470                 2475             


Tyr Val  Leu His Glu Gly Glu  Cys Cys Gly Arg Cys  Leu Pro Ser 
    2480                 2485                 2490             


Ala Cys  Glu Val Val Thr Gly  Ser Pro Arg Gly Asp  Ser Gln Ser 
    2495                 2500                 2505             


Ser Trp  Lys Ser Val Gly Ser  Gln Trp Ala Ser Pro  Glu Asn Pro 
    2510                 2515                 2520             


Cys Leu  Ile Asn Glu Cys Val  Arg Val Lys Glu Glu  Val Phe Ile 
    2525                 2530                 2535             


Gln Gln  Arg Asn Val Ser Cys  Pro Gln Leu Glu Val  Pro Val Cys 
    2540                 2545                 2550             


Pro Ser  Gly Phe Gln Leu Ser  Cys Lys Thr Ser Ala  Cys Cys Pro 
    2555                 2560                 2565             


Ser Cys  Arg Cys Glu Arg Met  Glu Ala Cys Met Leu  Asn Gly Thr 
    2570                 2575                 2580             


Val Ile  Gly Pro Gly Lys Thr  Val Met Ile Asp Val  Cys Thr Thr 
    2585                 2590                 2595             


Cys Arg  Cys Met Val Gln Val  Gly Val Ile Ser Gly  Phe Lys Leu 
    2600                 2605                 2610             


Glu Cys  Arg Lys Thr Thr Cys  Asn Pro Cys Pro Leu  Gly Tyr Lys 
    2615                 2620                 2625             


Glu Glu  Asn Asn Thr Gly Glu  Cys Cys Gly Arg Cys  Leu Pro Thr 
    2630                 2635                 2640             


Ala Cys  Thr Ile Gln Leu Arg  Gly Gly Gln Ile Met  Thr Leu Lys 
    2645                 2650                 2655             


Arg Asp  Glu Thr Leu Gln Asp  Gly Cys Asp Thr His  Phe Cys Lys 
    2660                 2665                 2670             


Val Asn  Glu Arg Gly Glu Tyr  Phe Trp Glu Lys Arg  Val Thr Gly 
    2675                 2680                 2685             


Cys Pro  Pro Phe Asp Glu His  Lys Cys Leu Ala Glu  Gly Gly Lys 
    2690                 2695                 2700             


Ile Met  Lys Ile Pro Gly Thr  Cys Cys Asp Thr Cys  Glu Glu Pro 
    2705                 2710                 2715             


Glu Cys  Asn Asp Ile Thr Ala  Arg Leu Gln Tyr Val  Lys Val Gly 
    2720                 2725                 2730             


Ser Cys  Lys Ser Glu Val Glu  Val Asp Ile His Tyr  Cys Gln Gly 
    2735                 2740                 2745             


Lys Cys  Ala Ser Lys Ala Met  Tyr Ser Ile Asp Ile  Asn Asp Val 
    2750                 2755                 2760             


Gln Asp  Gln Cys Ser Cys Cys  Ser Pro Thr Arg Thr  Glu Pro Met 
    2765                 2770                 2775             


Gln Val  Ala Leu His Cys Thr  Asn Gly Ser Val Val  Tyr His Glu 
    2780                 2785                 2790             


Val Leu  Asn Ala Met Glu Cys  Lys Cys Ser Pro Arg  Lys Cys Ser 
    2795                 2800                 2805             


Lys 
    


<210>  130
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AE36

<400>  130

Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 
1               5                   10                  15      


Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 
            20                  25                  30          


Ser Glu Thr Pro 
        35      


<210>  131
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AE42

<400>  131

Gly Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
1               5                   10                  15      


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 
            20                  25                  30          


Thr Ser Gly Ser Glu Thr Pro Ala Ser Ser 
        35                  40          


<210>  132
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AE72

<400>  132

Gly Ala Pro Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 
1               5                   10                  15      


Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 
            20                  25                  30          


Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 
        35                  40                  45              


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 
    50                  55                  60                  


Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ala Ser Ser 
65                  70                  75              


<210>  133
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AE78

<400>  133

Gly Ala Pro Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 
1               5                   10                  15      


Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 
            20                  25                  30          


Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 
        35                  40                  45              


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 
    50                  55                  60                  


Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ala Ser Ser 
65                  70                  75              


<210>  134
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AE144

<400>  134

Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 
1               5                   10                  15      


Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 
            20                  25                  30          


Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 
        35                  40                  45              


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 
    50                  55                  60                  


Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly 
65                  70                  75                  80  


Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
                85                  90                  95      


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 
            100                 105                 110         


Ser Ala Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 
        115                 120                 125             


Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
    130                 135                 140             


<210>  135
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AE144_6B

<400>  135

Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
            20                  25                  30          


Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
        35                  40                  45              


Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
    50                  55                  60                  


Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
65                  70                  75                  80  


Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
                85                  90                  95      


Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala 
            100                 105                 110         


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        115                 120                 125             


Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
    130                 135                 140                 


<210>  136
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AG144

<400>  136

Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 
1               5                   10                  15      


Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr 
            20                  25                  30          


Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 
        35                  40                  45              


Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro 
    50                  55                  60                  


Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 
65                  70                  75                  80  


Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 
                85                  90                  95      


Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Pro 
            100                 105                 110         


Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr Ala 
        115                 120                 125             


Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 
    130                 135                 140                 


<210>  137
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AG144_A

<400>  137

Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Pro 
1               5                   10                  15      


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 
            20                  25                  30          


Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 
        35                  40                  45              


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 
    50                  55                  60                  


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 
65                  70                  75                  80  


Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 
                85                  90                  95      


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly 
            100                 105                 110         


Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
        115                 120                 125             


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
    130                 135                 140                 


<210>  138
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AE288

<400>  138

Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 
1               5                   10                  15      


Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
            20                  25                  30          


Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
        35                  40                  45              


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 
    50                  55                  60                  


Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 
65                  70                  75                  80  


Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
                85                  90                  95      


Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 
            100                 105                 110         


Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 
        115                 120                 125             


Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 
    130                 135                 140                 


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 
145                 150                 155                 160 


Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 
                165                 170                 175     


Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
            180                 185                 190         


Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 
        195                 200                 205             


Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 
    210                 215                 220                 


Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
225                 230                 235                 240 


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 
                245                 250                 255     


Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
            260                 265                 270         


Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
        275                 280                 285             


<210>  139
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AE288_2

<400>  139

Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 
1               5                   10                  15      


Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 
            20                  25                  30          


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
        35                  40                  45              


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 
    50                  55                  60                  


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 
65                  70                  75                  80  


Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
                85                  90                  95      


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 
            100                 105                 110         


Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 
        115                 120                 125             


Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
    130                 135                 140                 


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 
145                 150                 155                 160 


Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
                165                 170                 175     


Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
            180                 185                 190         


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 
        195                 200                 205             


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 
    210                 215                 220                 


Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 
225                 230                 235                 240 


Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 
                245                 250                 255     


Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 
            260                 265                 270         


Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
        275                 280                 285             


<210>  140
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AG288

<400>  140

Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser 
1               5                   10                  15      


Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr 
            20                  25                  30          


Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 
        35                  40                  45              


Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser 
    50                  55                  60                  


Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr 
65                  70                  75                  80  


Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 
                85                  90                  95      


Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser 
            100                 105                 110         


Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser 
        115                 120                 125             


Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 
    130                 135                 140                 


Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser 
145                 150                 155                 160 


Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser 
                165                 170                 175     


Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly 
            180                 185                 190         


Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser 
        195                 200                 205             


Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly 
    210                 215                 220                 


Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly 
225                 230                 235                 240 


Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser 
                245                 250                 255     


Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr 
            260                 265                 270         


Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 
        275                 280                 285             


<210>  141
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AE576

<400>  141

Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 
1               5                   10                  15      


Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 
            20                  25                  30          


Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 
        35                  40                  45              


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 
    50                  55                  60                  


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 
65                  70                  75                  80  


Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
                85                  90                  95      


Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 
            100                 105                 110         


Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 
        115                 120                 125             


Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
    130                 135                 140                 


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 
145                 150                 155                 160 


Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 
                165                 170                 175     


Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
            180                 185                 190         


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 
        195                 200                 205             


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 
    210                 215                 220                 


Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
225                 230                 235                 240 


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 
                245                 250                 255     


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 
            260                 265                 270         


Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
        275                 280                 285             


Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 
    290                 295                 300                 


Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 
305                 310                 315                 320 


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
                325                 330                 335     


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 
            340                 345                 350         


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 
        355                 360                 365             


Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
    370                 375                 380                 


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 
385                 390                 395                 400 


Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 
                405                 410                 415     


Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
            420                 425                 430         


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 
        435                 440                 445             


Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
    450                 455                 460                 


Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
465                 470                 475                 480 


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 
                485                 490                 495     


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 
            500                 505                 510         


Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 
        515                 520                 525             


Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 
    530                 535                 540                 


Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 
545                 550                 555                 560 


Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
                565                 570                 575     


<210>  142
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AG576

<400>  142

Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser 
1               5                   10                  15      


Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser 
            20                  25                  30          


Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly 
        35                  40                  45              


Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser 
    50                  55                  60                  


Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser 
65                  70                  75                  80  


Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 
                85                  90                  95      


Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro 
            100                 105                 110         


Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser 
        115                 120                 125             


Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 
    130                 135                 140                 


Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser 
145                 150                 155                 160 


Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr 
                165                 170                 175     


Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 
            180                 185                 190         


Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser 
        195                 200                 205             


Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly 
    210                 215                 220                 


Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 
225                 230                 235                 240 


Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro 
                245                 250                 255     


Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly 
            260                 265                 270         


Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 
        275                 280                 285             


Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser 
    290                 295                 300                 


Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser 
305                 310                 315                 320 


Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 
                325                 330                 335     


Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser 
            340                 345                 350         


Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser 
        355                 360                 365             


Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 
    370                 375                 380                 


Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro 
385                 390                 395                 400 


Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly 
                405                 410                 415     


Ala Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser 
            420                 425                 430         


Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro 
        435                 440                 445             


Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly 
    450                 455                 460                 


Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 
465                 470                 475                 480 


Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser 
                485                 490                 495     


Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser 
            500                 505                 510         


Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser 
        515                 520                 525             


Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser 
    530                 535                 540                 


Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser 
545                 550                 555                 560 


Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 
                565                 570                 575     


<210>  143
<211>  864
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AE864

<400>  143

Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 
1               5                   10                  15      


Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 
            20                  25                  30          


Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 
        35                  40                  45              


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 
    50                  55                  60                  


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 
65                  70                  75                  80  


Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
                85                  90                  95      


Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 
            100                 105                 110         


Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 
        115                 120                 125             


Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
    130                 135                 140                 


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 
145                 150                 155                 160 


Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 
                165                 170                 175     


Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
            180                 185                 190         


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 
        195                 200                 205             


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 
    210                 215                 220                 


Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
225                 230                 235                 240 


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 
                245                 250                 255     


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 
            260                 265                 270         


Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
        275                 280                 285             


Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 
    290                 295                 300                 


Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 
305                 310                 315                 320 


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
                325                 330                 335     


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 
            340                 345                 350         


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 
        355                 360                 365             


Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
    370                 375                 380                 


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 
385                 390                 395                 400 


Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 
                405                 410                 415     


Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
            420                 425                 430         


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 
        435                 440                 445             


Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
    450                 455                 460                 


Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
465                 470                 475                 480 


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 
                485                 490                 495     


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 
            500                 505                 510         


Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 
        515                 520                 525             


Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 
    530                 535                 540                 


Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 
545                 550                 555                 560 


Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
                565                 570                 575     


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 
            580                 585                 590         


Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
        595                 600                 605             


Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
    610                 615                 620                 


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 
625                 630                 635                 640 


Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 
                645                 650                 655     


Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
            660                 665                 670         


Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 
        675                 680                 685             


Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 
    690                 695                 700                 


Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 
705                 710                 715                 720 


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 
                725                 730                 735     


Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 
            740                 745                 750         


Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
        755                 760                 765             


Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 
    770                 775                 780                 


Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 
785                 790                 795                 800 


Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
                805                 810                 815     


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 
            820                 825                 830         


Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
        835                 840                 845             


Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
    850                 855                 860                 


<210>  144
<211>  864
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AG864

<400>  144

Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Pro 
1               5                   10                  15      


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 
            20                  25                  30          


Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 
        35                  40                  45              


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 
    50                  55                  60                  


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 
65                  70                  75                  80  


Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 
                85                  90                  95      


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly 
            100                 105                 110         


Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
        115                 120                 125             


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
    130                 135                 140                 


Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 
145                 150                 155                 160 


Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
                165                 170                 175     


Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 
            180                 185                 190         


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 
        195                 200                 205             


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 
    210                 215                 220                 


Gly Thr Gly Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 
225                 230                 235                 240 


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro 
                245                 250                 255     


Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
            260                 265                 270         


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
        275                 280                 285             


Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro 
    290                 295                 300                 


Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
305                 310                 315                 320 


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
                325                 330                 335     


Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly 
            340                 345                 350         


Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
        355                 360                 365             


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
    370                 375                 380                 


Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr 
385                 390                 395                 400 


Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 
                405                 410                 415     


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
            420                 425                 430         


Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 
        435                 440                 445             


Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 
    450                 455                 460                 


Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 
465                 470                 475                 480 


Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro 
                485                 490                 495     


Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
            500                 505                 510         


Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 
        515                 520                 525             


Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro 
    530                 535                 540                 


Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
545                 550                 555                 560 


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
                565                 570                 575     


Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 
            580                 585                 590         


Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala 
        595                 600                 605             


Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 
    610                 615                 620                 


Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 
625                 630                 635                 640 


Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 
                645                 650                 655     


Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 
            660                 665                 670         


Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro 
        675                 680                 685             


Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala 
    690                 695                 700                 


Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 
705                 710                 715                 720 


Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro 
                725                 730                 735     


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 
            740                 745                 750         


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
        755                 760                 765             


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 
    770                 775                 780                 


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 
785                 790                 795                 800 


Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 
                805                 810                 815     


Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 
            820                 825                 830         


Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 
        835                 840                 845             


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
    850                 855                 860                 


<210>  145
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN_AE72_2A_1

<400>  145

Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
        35                  40                  45              


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 
    50                  55                  60                  


Pro Ser Glu Gly Ser Ala Pro Gly 
65                  70          


<210>  146
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN_AE72_2A_2

<400>  146

Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
        35                  40                  45              


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser 
    50                  55                  60                  


Ala Thr Pro Glu Ser Gly Pro Gly 
65                  70          


<210>  147
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN_AE72_3B_1

<400>  147

Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 
            20                  25                  30          


Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
        35                  40                  45              


Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 
    50                  55                  60                  


Pro Ser Glu Gly Ser Ala Pro Gly 
65                  70          


<210>  148
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN_AE72_3B_2

<400>  148

Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
        35                  40                  45              


Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu 
    50                  55                  60                  


Pro Ser Glu Gly Ser Ala Pro Gly 
65                  70          


<210>  149
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN_AE72_4A_2

<400>  149

Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser 
            20                  25                  30          


Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
        35                  40                  45              


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 
    50                  55                  60                  


Pro Ser Glu Gly Ser Ala Pro Gly 
65                  70          


<210>  150
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN_AE72_5A_2

<400>  150

Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 
            20                  25                  30          


Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
        35                  40                  45              


Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly 
    50                  55                  60                  


Ser Pro Thr Ser Thr Glu Glu Gly 
65                  70          


<210>  151
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN_AE72_6B_1

<400>  151

Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
            20                  25                  30          


Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
        35                  40                  45              


Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
    50                  55                  60                  


Thr Ser Gly Ser Glu Thr Pro Gly 
65                  70          


<210>  152
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN_AE72_6B_2

<400>  152

Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 
        35                  40                  45              


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 
    50                  55                  60                  


Pro Ser Glu Gly Ser Ala Pro Gly 
65                  70          


<210>  153
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN_AE72_1A_1

<400>  153

Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
        35                  40                  45              


Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 
    50                  55                  60                  


Pro Ser Glu Gly Ser Ala Pro Gly 
65                  70          


<210>  154
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN_AE72_1A_2

<400>  154

Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 
            20                  25                  30          


Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
        35                  40                  45              


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 
    50                  55                  60                  


Pro Ser Glu Gly Ser Ala Pro Gly 
65                  70          


<210>  155
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN_AE144_1A

<400>  155

Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
        35                  40                  45              


Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 
    50                  55                  60                  


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
65                  70                  75                  80  


Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 
                85                  90                  95      


Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
            100                 105                 110         


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        115                 120                 125             


Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
    130                 135                 140                 


<210>  156
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AE150

<400>  156

Gly Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 
1               5                   10                  15      


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 
            20                  25                  30          


Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
        35                  40                  45              


Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
    50                  55                  60                  


Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
65                  70                  75                  80  


Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 
                85                  90                  95      


Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
            100                 105                 110         


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 
        115                 120                 125             


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
    130                 135                 140                 


Ser Ala Pro Ala Ser Ser 
145                 150 


<210>  157
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G150

<400>  157

Gly Ala Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly 
1               5                   10                  15      


Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser 
            20                  25                  30          


Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly 
        35                  40                  45              


Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly 
    50                  55                  60                  


Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr Pro 
65                  70                  75                  80  


Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly 
                85                  90                  95      


Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly 
            100                 105                 110         


Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly Ser 
        115                 120                 125             


Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr 
    130                 135                 140                 


Gly Ser Pro Ala Ser Ser 
145                 150 


<210>  158
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AE294

<400>  158

Gly Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
1               5                   10                  15      


Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
            20                  25                  30          


Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 
        35                  40                  45              


Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
    50                  55                  60                  


Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 
65                  70                  75                  80  


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu 
                85                  90                  95      


Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 
            100                 105                 110         


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly 
        115                 120                 125             


Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser 
    130                 135                 140                 


Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
145                 150                 155                 160 


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser 
                165                 170                 175     


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
            180                 185                 190         


Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 
        195                 200                 205             


Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
    210                 215                 220                 


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 
225                 230                 235                 240 


Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
                245                 250                 255     


Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
            260                 265                 270         


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
        275                 280                 285             


Ser Ala Pro Ala Ser Ser 
    290                 


<210>  159
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AG294

<400>  159

Gly Ala Pro Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
1               5                   10                  15      


Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly 
            20                  25                  30          


Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 
        35                  40                  45              


Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 
    50                  55                  60                  


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly 
65                  70                  75                  80  


Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 
                85                  90                  95      


Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 
            100                 105                 110         


Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro 
        115                 120                 125             


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 
    130                 135                 140                 


Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 
145                 150                 155                 160 


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 
                165                 170                 175     


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 
            180                 185                 190         


Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
        195                 200                 205             


Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr 
    210                 215                 220                 


Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr 
225                 230                 235                 240 


Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
                245                 250                 255     


Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly 
            260                 265                 270         


Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 
        275                 280                 285             


Thr Gly Ser Ala Ser Ser 
    290                 


<210>  160
<211>  1016
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIX-Linker-Albumin

<400>  160

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              


Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  


Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  


Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      


Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         


Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             


Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 


Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 


Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     


Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         


Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             


Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 


Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 


Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     


His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         


Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             


Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 


Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 


Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     


Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         


Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             


His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 


Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 


Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Pro 
                405                 410                 415     


Val Ser Gln Thr Ser Lys Leu Thr Arg Ala Glu Thr Val Phe Pro Asp 
            420                 425                 430         


Val Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
        435                 440                 445             


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
    450                 455                 460                 


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
465                 470                 475                 480 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
                485                 490                 495     


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
            500                 505                 510         


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
        515                 520                 525             


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
    530                 535                 540                 


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
545                 550                 555                 560 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
                565                 570                 575     


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
            580                 585                 590         


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
        595                 600                 605             


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
    610                 615                 620                 


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
625                 630                 635                 640 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
                645                 650                 655     


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
            660                 665                 670         


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
        675                 680                 685             


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
    690                 695                 700                 


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
705                 710                 715                 720 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
                725                 730                 735     


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
            740                 745                 750         


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
        755                 760                 765             


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
    770                 775                 780                 


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Phe Cys 
785                 790                 795                 800 


Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln 
                805                 810                 815     


Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr 
            820                 825                 830         


Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln 
        835                 840                 845             


Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val 
    850                 855                 860                 


Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala 
865                 870                 875                 880 


Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu 
                885                 890                 895     


Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu 
            900                 905                 910         


Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr 
        915                 920                 925             


Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile 
    930                 935                 940                 


Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu 
945                 950                 955                 960 


Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys 
                965                 970                 975     


Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala 
            980                 985                 990         


Asp Asp Lys Glu Thr Cys Phe Ala  Glu Glu Gly Lys Lys  Leu Val Ala 
        995                 1000                 1005             


Ala Ser  Gln Ala Ala Leu Gly  Leu 
    1010                 1015     


<210>  161
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIX

<400>  161

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              


Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  


Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  


Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      


Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         


Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             


Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 


Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 


Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     


Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         


Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             


Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 


Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 


Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     


His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         


Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             


Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 


Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 


Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     


Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         


Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             


His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 


Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 


Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Pro 
                405                 410                 415     


Val Ser Gln Thr Ser Lys Leu Thr 
            420                 


<210>  162
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  162

Arg Ala Glu Thr Val Phe Pro Asp Val 
1               5                   


<210>  163
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin

<400>  163

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  164
<211>  763
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIX(XTEN )-Fc

<400>  164

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Gly Pro Ser Pro Gly Ser Pro Thr Ser Thr Glu Glu 
    210                 215                 220                 


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 
225                 230                 235                 240 


Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
                245                 250                 255     


Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
            260                 265                 270         


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ala Ser Ser 
        275                 280                 285             


Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe Thr Arg Val Val 
    290                 295                 300                 


Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp Gln Val Val Leu 
305                 310                 315                 320 


Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile Val Asn Glu Lys 
                325                 330                 335     


Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly Val Lys Ile Thr 
            340                 345                 350         


Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu His Thr Glu Gln 
        355                 360                 365             


Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn Tyr Asn Ala Ala 
    370                 375                 380                 


Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu Leu Asp Glu Pro 
385                 390                 395                 400 


Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile Ala Asp Lys Glu 
                405                 410                 415     


Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr Val Ser Gly Trp 
            420                 425                 430         


Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val Leu Gln Tyr Leu 
        435                 440                 445             


Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Leu Ser Thr Lys Phe 
    450                 455                 460                 


Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His Glu Gly Gly Arg 
465                 470                 475                 480 


Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Glu Val Glu 
                485                 490                 495     


Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly Glu Glu Cys Ala 
            500                 505                 510         


Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser Arg Tyr Val Asn 
        515                 520                 525             


Trp Ile Lys Glu Lys Thr Lys Leu Thr Asp Lys Thr His Thr Cys Pro 
    530                 535                 540                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
545                 550                 555                 560 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                565                 570                 575     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            580                 585                 590         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        595                 600                 605             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    610                 615                 620                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
625                 630                 635                 640 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                645                 650                 655     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            660                 665                 670         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        675                 680                 685             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    690                 695                 700                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
705                 710                 715                 720 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                725                 730                 735     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            740                 745                 750         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        755                 760             


<210>  165
<211>  712
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIX-FXIa-AE288

<400>  165

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              


Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  


Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  


Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      


Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         


Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             


Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 


Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 


Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     


Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         


Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             


Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 


Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 


Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     


His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         


Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             


Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 


Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 


Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     


Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         


Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             


His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 


Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 


Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Gly 
                405                 410                 415     


Lys Leu Thr Arg Ala Glu Thr Gly Gly Thr Ser Glu Ser Ala Thr Pro 
            420                 425                 430         


Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
        435                 440                 445             


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 
    450                 455                 460                 


Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
465                 470                 475                 480 


Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
                485                 490                 495     


Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 
            500                 505                 510         


Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 
        515                 520                 525             


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
    530                 535                 540                 


Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 
545                 550                 555                 560 


Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 
                565                 570                 575     


Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
            580                 585                 590         


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu 
        595                 600                 605             


Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 
    610                 615                 620                 


Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
625                 630                 635                 640 


Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 
                645                 650                 655     


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 
            660                 665                 670         


Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
        675                 680                 685             


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 
    690                 695                 700                 


Glu Pro Ser Glu Gly Ser Ala Pro 
705                 710         


<210>  166
<211>  944
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIX-Fc-Fc

<400>  166

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Asp Lys Thr 
    450                 455                 460                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
465                 470                 475                 480 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                485                 490                 495     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            500                 505                 510         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        515                 520                 525             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    530                 535                 540                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
545                 550                 555                 560 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                565                 570                 575     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            580                 585                 590         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        595                 600                 605             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    610                 615                 620                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
625                 630                 635                 640 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                645                 650                 655     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            660                 665                 670         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        675                 680                 685             


Arg Arg Arg Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    690                 695                 700                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Arg Arg Arg Asp Lys Thr 
705                 710                 715                 720 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                725                 730                 735     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            740                 745                 750         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        755                 760                 765             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    770                 775                 780                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
785                 790                 795                 800 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                805                 810                 815     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            820                 825                 830         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        835                 840                 845             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    850                 855                 860                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
865                 870                 875                 880 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                885                 890                 895     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            900                 905                 910         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        915                 920                 925             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    930                 935                 940                 


<210>  167
<211>  383
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Parvovirus B19 KY940273.1

<400>  167
ccaaatcaga tgccgccggt cgccgccggt aggcgggact tccggtacaa gatggcggac       60

aattacgtca tttcctgtga cgtcatttcc tgtgacgtca cttccggtgg gcgggacttc      120

cggaattagg gttggctctg ggccagcttg cttggggttg ccttgacact aagacaagcg      180

gcgcgccgct tgatcttagt ggcacgtcaa ccccaagcgc tggcccagag ccaaccctaa      240

ttccggaagt cccgcccacc ggaagtgacg tcacaggaaa tgacgtcaca ggaaatgacg      300

taattgtccg ccatcttgta ccggaagtcc cgcctaccgg cggcgaccgg cggcatctga      360

tttggtgtct tcttttaaat ttt                                              383


<210>  168
<211>  248
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Parvorius B19 d135

<400>  168
ctctgggcca gcttgcttgg ggttgccttg acactaagac aagcggcgcg ccgcttgatc       60

ttagtggcac gtcaacccca agcgctggcc cagagccaac cctaattccg gaagtcccgc      120

ccaccggaag tgacgtcaca ggaaatgacg tcacaggaaa tgacgtaatt gtccgccatc      180

ttgtaccgga agtcccgcct accggcggcg accggcggca tctgatttgg tgtcttcttt      240

taaatttt                                                               248


<210>  169
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Parvovirus v1  AAV2

<400>  169
cggcgcgccg cttgatctta gtggcacgtc aaccagcgct ggcccagagc caaccctaat       60

tccggaagtc ctcagtccgc catcttgccc gcctaccggc ggcgaccggc ggcatcattt      120

ggtgttctt                                                              129


<210>  170
<211>  113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Parvovirus V2

<400>  170
ctctgggcca gcttgcttgg ggttgccttg acactaagac aagcggcgcg ccgcttgatc       60

ttagtggcac gtcaacccca agcgctggcc cagagtgtct tcttttaaat ttt             113


<210>  171
<211>  340
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Parvovirus V3

<400>  171
caaatcagat gccgccggtc gccgccggta ggcgggactt ccggtacaag atggcggaca       60

attacgtcat ttcctgtgac gtatttcctg tgacgtactt ccggtggcgg gacttccgga      120

attttggctc tgggccagct tgcttggggt tgccttgacc aagcgcgcgc cgcttgatca      180

ccccaagcgc tggcccagag ccacctaacc ggaagtcccc ccaccggaag tgacgtcaca      240

ggaaagacgt cacaggaagt aattgtccgc catcttgtac cggaagtccc gcaccggcgg      300

cgaccggcgg catctgattt ggtgtcttct tttaaatttt                            340


<210>  172
<211>  444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Parvovirus U25749.1

<400>  172
ctcattggag ggttcgttcg ttcgaaccag ccaatcaggg gagggggaag tgacgcaagt       60

tccggtcaca tgcttccggt gacgcacatc cggtgacgta gttccggtca cgtgcttcct      120

gtcacgtgtt tccggtcacg tgacttccgg tcatgtgact tccggtgacg tgtttccggc      180

tgttaggttg accacgcgca tgccgcgcgg tcagcccaat agttaagccg gaaacacgtc      240

accggaagtc acatgaccgg aagtcacgtg accggaaaca cgtgacagga agcacgtgac      300

cggaactacg tcaccggatg tgcgtcaccg gaagcatgtg accggaactt gcgtcacttc      360

cccctcccct gattggctgg ttcgaacgaa cgaaccctcc aatgagactc aaggacaaga      420

ggatattttg cgcgccagga agtg                                             444


<210>  173
<211>  282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Parvovirus GPV AAV2 V1

<400>  173
cggtgacgtg tttccggctg ttaggttgac cacgcgcatg ccgcgcggtc agcccaatag       60

ttaagccgga aacacgtcac cggaagtcac atgaccggaa gtcacgtgac cggaaacacg      120

tgacaggaag cacgtgaccg gaactacgtc accggatgtg cgtcaccgga agcatgtgac      180

cggaacttgc gtcacttccc cctcccctga ttggctggtt cgaacgaacg aaccctccaa      240

tgagactcaa ggacaagagg atattttgcg cgccaggaag tg                         282


<210>  174
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Parvovirus GPV AAV2 V1

<400>  174
ttgaccacgc gcatgccgcg cggtcagccc aatagttaag ccgggtgacc acacgtgaca       60

ggaagcacgg gatgtgcgtc accggaagca gtgaccgggc tggttcgaac gaacgaaccc      120

tccaactcaa ggacaagagg atatt                                            145


<210>  175
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Parvovirus GPV V2

<400>  175
cggtgacgtg tttccggctg ttaggttgac cacgcgcatg ccgcgcggtc agcccaatag       60

ttaagccgga aacacgtcac cgactcaagg acaagaggat attttgcgcg ccaggaagtg      120


<210>  176
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Parvovirus GPV V3

<400>  176
gggaacaatc aggggaagtg accggtgacg tcatgtaact tgcgtcactt cccgttcgaa       60

cgaacgaacg agactcaagg acaagaggcg cgccaggaag tg                         102


<210>  177
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Parvovirus AAV2 NC_001401.2

<400>  177
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcct                                            145


<210>  178
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Parvovirus Gtx

<400>  178
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  179
<211>  6762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B19-FVIII construct

<400>  179
ctctgggcca gcttgcttgg ggttgccttg acactaagac aagcggcgcg ccgcttgatc       60

ttagtggcac gtcaacccca agcgctggcc cagagccaac cctaattccg gaagtcccgc      120

ccaccggaag tgacgtcaca ggaaatgacg tcacaggaaa tgacgtaatt gtccgccatc      180

ttgtaccgga agtcccgcct accggcggcg accggcggca tctgatttgg tgtcttcttt      240

taaattttgc ggcaattcag tcgataacta taacggtcct aaggtagcga tttaaatacg      300

cgctctctta aggtagcccc gggacgcgtc aattgagatc tggatccggt accgaattcg      360

cggccgcctc gacgactagc gtttaattaa acgcgtgtct gtctgcacat ttcgtagagc      420

gagtgttccg atactctaat ctccctaggc aaggttcata tttgtgtagg ttacttattc      480

tccttttgtt gactaagtca ataatcagaa tcagcaggtt tggagtcagc ttggcaggga      540

tcagcagcct gggttggaag gagggggtat aaaagcccct tcaccaggag aagccgtcac      600

acagatccac aagctcctga ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt      660

acgggttatg gcccttgcgt gccttgaatt actgacactg acatccactt tttctttttc      720

tccacagcta gcgccaccat gcagattgag ctgtccactt gtttcttcct gtgcctcctg      780

cgcttctgtt tctccgccac tcgccggtac taccttggag ccgtggagct ttcatgggac      840

tacatgcaga gcgacctggg cgaactcccc gtggatgcca gattcccccc ccgcgtgcca      900

aagtccttcc cctttaacac ctccgtggtg tacaagaaaa ccctctttgt cgagttcact      960

gaccacctgt tcaacatcgc caagccgcgc ccaccttgga tgggcctcct gggaccgacc     1020

attcaagctg aagtgtacga caccgtggtg atcaccctga agaacatggc gtcccacccc     1080

gtgtccctgc atgcggtcgg agtgtcctac tggaaggcct ccgaaggagc tgagtacgac     1140

gaccagacta gccagcggga aaaggaggac gataaagtgt tcccgggcgg ctcgcatact     1200

tacgtgtggc aagtcctgaa ggaaaacgga cctatggcat ccgatcctct gtgcctgact     1260

tactcctacc tttcccatgt ggacctcgtg aaggacctga acagcgggct gattggtgca     1320

cttctcgtgt gccgcgaagg ttcgctcgct aaggaaaaga cccagaccct ccataagttc     1380

atccttttgt tcgctgtgtt cgatgaagga aagtcatggc attccgaaac taagaactcg     1440

ctgatgcagg accgggatgc cgcctcagcc cgcgcctggc ctaaaatgca tacagtcaac     1500

ggatacgtga atcggtcact gcccgggctc atcggttgtc acagaaagtc cgtgtactgg     1560

cacgtcatcg gcatgggcac tacgcctgaa gtgcactcca tcttcctgga agggcacacc     1620

ttcctcgtgc gcaaccaccg ccaggcctct ctggaaatct ccccgattac ctttctgacc     1680

gcccagactc tgctcatgga cctggggcag ttccttctct tctgccacat ctccagccat     1740

cagcacgacg gaatggaggc ctacgtgaag gtggactcat gcccggaaga acctcagttg     1800

cggatgaaga acaacgagga ggccgaggac tatgacgacg atttgactga ctccgagatg     1860

gacgtcgtgc ggttcgatga cgacaacagc cccagcttca tccagattcg cagcgtggcc     1920

aagaagcacc ccaaaacctg ggtgcactac atcgcggccg aggaagaaga ttgggactac     1980

gccccgttgg tgctggcacc cgatgaccgg tcgtacaagt cccagtatct gaacaatggt     2040

ccgcagcgga ttggcagaaa gtacaagaaa gtgcggttca tggcgtacac tgacgaaacg     2100

tttaagaccc gggaggccat tcaacatgag agcggcattc tgggaccact gctgtacgga     2160

gaggtcggcg ataccctgct catcatcttc aaaaaccagg cctcccggcc ttacaacatc     2220

taccctcacg gaatcaccga cgtgcggcca ctctactcgc ggcgcctgcc gaagggcgtc     2280

aagcacctga aagacttccc tatcctgccg ggcgaaatct tcaagtataa gtggaccgtc     2340

accgtggagg acgggcccac caagagcgat cctaggtgtc tgactcggta ctactccagc     2400

ttcgtgaaca tggaacggga cctggcatcg ggactcattg gaccgctgct gatctgctac     2460

aaagagtcgg tggatcaacg cggcaaccag atcatgtccg acaagcgcaa cgtgatcctg     2520

ttctccgtgt ttgatgaaaa cagatcctgg tacctcactg aaaacatcca gaggttcctc     2580

ccaaaccccg caggagtgca actggaggac cctgagtttc aggcctcgaa tatcatgcac     2640

tcgattaacg gttacgtgtt cgactcgctg caactgagcg tgtgcctcca tgaagtcgct     2700

tactggtaca ttctgtccat cggcgcccag actgacttcc tgagcgtgtt cttttccggt     2760

tacaccttta agcacaagat ggtgtacgaa gataccctga ccctgttccc tttctccggc     2820

gaaacggtgt tcatgtcgat ggagaacccg ggtctgtgga ttctgggatg ccacaacagc     2880

gactttcgga accgcggaat gactgccctg ctgaaggtgt cctcatgcga caagaacacc     2940

ggagactact acgaggactc ctacgaggat atctcagcct acctcctgtc caagaacaac     3000

gcgatcgagc cgcgcagctt cagccagaac ggcgcgccaa catcagagag cgccacccct     3060

gaaagtggtc ccgggagcga gccagccaca tctgggtcgg aaacgccagg cacaagtgag     3120

tctgcaactc ccgagtccgg acctggctcc gagcctgcca ctagcggctc cgagactccg     3180

ggaacttccg agagcgctac accagaaagc ggacccggaa ccagtaccga acctagcgag     3240

ggctctgctc cgggcagccc agccggctct cctacatcca cggaggaggg cacttccgaa     3300

tccgccaccc cggagtcagg gccaggatct gaacccgcta cctcaggcag tgagacgcca     3360

ggaacgagcg agtccgctac accggagagt gggccaggga gccctgctgg atctcctacg     3420

tccactgagg aagggtcacc agcgggctcg cccaccagca ctgaagaagg tgcctcgagc     3480

ccgcctgtgc tgaagaggca ccagcgagaa attacccgga ccaccctcca atcggatcag     3540

gaggaaatcg actacgacga caccatctcg gtggaaatga agaaggaaga tttcgatatc     3600

tacgacgagg acgaaaatca gtcccctcgc tcattccaaa agaaaactag acactacttt     3660

atcgccgcgg tggaaagact gtgggactat ggaatgtcat ccagccctca cgtccttcgg     3720

aaccgggccc agagcggatc ggtgcctcag ttcaagaaag tggtgttcca ggagttcacc     3780

gacggcagct tcacccagcc gctgtaccgg ggagaactga acgaacacct gggcctgctc     3840

ggtccctaca tccgcgcgga agtggaggat aacatcatgg tgaccttccg taaccaagca     3900

tccagacctt actccttcta ttcctccctg atctcatacg aggaggacca gcgccaaggc     3960

gccgagcccc gcaagaactt cgtcaagccc aacgagacta agacctactt ctggaaggtc     4020

caacaccata tggccccgac caaggatgag tttgactgca aggcctgggc ctacttctcc     4080

gacgtggacc ttgagaagga tgtccattcc ggcctgatcg ggccgctgct cgtgtgtcac     4140

accaacaccc tgaacccagc gcatggacgc caggtcaccg tccaggagtt tgctctgttc     4200

ttcaccattt ttgacgaaac taagtcctgg tacttcaccg agaatatgga gcgaaactgt     4260

agagcgccct gcaatatcca gatggaagat ccgactttca aggagaacta tagattccac     4320

gccatcaacg ggtacatcat ggatactctg ccggggctgg tcatggccca ggatcagagg     4380

attcggtggt acttgctgtc aatgggatcg aacgaaaaca ttcactccat tcacttctcc     4440

ggtcacgtgt tcactgtgcg caagaaggag gagtacaaga tggcgctgta caatctgtac     4500

cccggggtgt tcgaaactgt ggagatgctg ccgtccaagg ccggcatctg gagagtggag     4560

tgcctgatcg gagagcacct ccacgcgggg atgtccaccc tcttcctggt gtactcgaat     4620

aagtgccaga ccccgctggg catggcctcg ggccacatca gagacttcca gatcacagca     4680

agcggacaat acggccaatg ggcgccgaag ctggcccgct tgcactactc cggatcgatc     4740

aacgcatggt ccaccaagga accgttctcg tggattaagg tggacctcct ggcccctatg     4800

attatccacg gaattaagac ccagggcgcc aggcagaagt tctcctccct gtacatctcg     4860

caattcatca tcatgtacag cctggacggg aagaagtggc agacttacag gggaaactcc     4920

accggcaccc tgatggtctt tttcggcaac gtggattcct ccggcattaa gcacaacatc     4980

ttcaacccac cgatcatagc cagatatatt aggctccacc ccactcacta ctcaatccgc     5040

tcaactcttc ggatggaact catggggtgc gacctgaact cctgctccat gccgttgggg     5100

atggaatcaa aggctattag cgacgcccag atcaccgcga gctcctactt cactaacatg     5160

ttcgccacct ggagcccctc caaggccagg ctgcacttgc agggacggtc aaatgcctgg     5220

cggccgcaag tgaacaatcc gaaggaatgg cttcaagtgg atttccaaaa gaccatgaaa     5280

gtgaccggag tcaccaccca gggagtgaag tcccttctga cctcgatgta tgtgaaggag     5340

ttcctgatta gcagcagcca ggacgggcac cagtggaccc tgttcttcca aaacggaaag     5400

gtcaaggtgt tccaggggaa ccaggactcg ttcacacccg tggtgaactc cctggacccc     5460

ccactgctga cgcggtactt gaggattcat cctcagtcct gggtccatca gattgcattg     5520

cgaatggaag tcctgggctg cgaggcccag gacctgtact gaatcagcct gagctcgctg     5580

atcataatca acctctggat tacaaaattt gtgaaagatt gactggtatt cttaactatg     5640

ttgctccttt tacgctatgt ggatacgctg ctttaatgcc tttgtatcat gctattgctt     5700

cccgtatggc tttcattttc tcctccttgt ataaatcctg gttgctgtct ctttatgagg     5760

agttgtggcc cgttgtcagg caacgtggcg tggtgtgcac tgtgtttgct gacgcaaccc     5820

ccactggttg gggcattgcc accacctgtc agctcctttc cgggactttc gctttccccc     5880

tccctattgc cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg acaggggctc     5940

ggctgttggg cactgacaat tccgtggtgt tgtcggggaa atcatcgtcc tttccttggc     6000

tgctcgcctg tgttgccacc tggattctgc gcgggacgtc cttctgctac gtcccttcgg     6060

ccctcaatcc agcggacctt ccttcccgcg gcctgctgcc ggctctgcgg cctcttccgc     6120

gtcttcgcct tcgccctcag acgagtcgga tctccctttg ggccgcctcc ccgctgatca     6180

gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc     6240

ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg     6300

cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg     6360

gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat ggcttctgag     6420

gcggaaagaa cgggctcgag aagcttctag atatcctctc ttaaggtagc atcgagattt     6480

aaattaggga taacagggta atggcgcggg ccgcaaaatt taaaagaaga caccaaatca     6540

gatgccgccg gtcgccgccg gtaggcggga cttccggtac aagatggcgg acaattacgt     6600

catttcctgt gacgtcattt cctgtgacgt cacttccggt gggcgggact tccggaatta     6660

gggttggctc tgggccagcg cttggggttg acgtgccact aagatcaagc ggcgcgccgc     6720

ttgtcttagt gtcaaggcaa ccccaagcaa gctggcccag ag                        6762


<210>  180
<211>  248
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'ITR

<400>  180
ctctgggcca gcttgcttgg ggttgccttg acactaagac aagcggcgcg ccgcttgatc       60

ttagtggcac gtcaacccca agcgctggcc cagagccaac cctaattccg gaagtcccgc      120

ccaccggaag tgacgtcaca ggaaatgacg tcacaggaaa tgacgtaatt gtccgccatc      180

ttgtaccgga agtcccgcct accggcggcg accggcggca tctgatttgg tgtcttcttt      240

taaatttt                                                               248


<210>  181
<211>  248
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' ITR inverted terminal repeat

<400>  181
ctctgggcca gcttgcttgg ggttgccttg acactaagac aagcggcgcg ccgcttgatc       60

ttagtggcac gtcaacccca agcgctggcc cagagccaac cctaattccg gaagtcccgc      120

ccaccggaag tgacgtcaca ggaaatgacg tcacaggaaa tgacgtaatt gtccgccatc      180

ttgtaccgga agtcccgcct accggcggcg accggcggca tctgatttgg tgtcttcttt      240

taaatttt                                                               248


<210>  182
<211>  6830
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GPV-FVIII construct

<400>  182
cggtgacgtg tttccggctg ttaggttgac cacgcgcatg ccgcgcggtc agcccaatag       60

ttaagccgga aacacgtcac cggaagtcac atgaccggaa gtcacgtgac cggaaacacg      120

tgacaggaag cacgtgaccg gaactacgtc accggatgtg cgtcaccgga agcatgtgac      180

cggaacttgc gtcacttccc cctcccctga ttggctggtt cgaacgaacg aaccctccaa      240

tgagactcaa ggacaagagg atattttgcg cgccaggaag tggcggcaat tcagtcgata      300

actataacgg tcctaaggta gcgatttaaa tacgcgctct cttaaggtag ccccgggacg      360

cgtcaattga gatctggatc cggtaccgaa ttcgcggccg cctcgacgac tagcgtttaa      420

ttaaacgcgt gtctgtctgc acatttcgta gagcgagtgt tccgatactc taatctccct      480

aggcaaggtt catatttgtg taggttactt attctccttt tgttgactaa gtcaataatc      540

agaatcagca ggtttggagt cagcttggca gggatcagca gcctgggttg gaaggagggg      600

gtataaaagc cccttcacca ggagaagccg tcacacagat ccacaagctc ctgaggtaag      660

tgccgtgtgt ggttcccgcg ggcctggcct ctttacgggt tatggccctt gcgtgccttg      720

aattactgac actgacatcc actttttctt tttctccaca gctagcgcca ccatgcagat      780

tgagctgtcc acttgtttct tcctgtgcct cctgcgcttc tgtttctccg ccactcgccg      840

gtactacctt ggagccgtgg agctttcatg ggactacatg cagagcgacc tgggcgaact      900

ccccgtggat gccagattcc ccccccgcgt gccaaagtcc ttccccttta acacctccgt      960

ggtgtacaag aaaaccctct ttgtcgagtt cactgaccac ctgttcaaca tcgccaagcc     1020

gcgcccacct tggatgggcc tcctgggacc gaccattcaa gctgaagtgt acgacaccgt     1080

ggtgatcacc ctgaagaaca tggcgtccca ccccgtgtcc ctgcatgcgg tcggagtgtc     1140

ctactggaag gcctccgaag gagctgagta cgacgaccag actagccagc gggaaaagga     1200

ggacgataaa gtgttcccgg gcggctcgca tacttacgtg tggcaagtcc tgaaggaaaa     1260

cggacctatg gcatccgatc ctctgtgcct gacttactcc tacctttccc atgtggacct     1320

cgtgaaggac ctgaacagcg ggctgattgg tgcacttctc gtgtgccgcg aaggttcgct     1380

cgctaaggaa aagacccaga ccctccataa gttcatcctt ttgttcgctg tgttcgatga     1440

aggaaagtca tggcattccg aaactaagaa ctcgctgatg caggaccggg atgccgcctc     1500

agcccgcgcc tggcctaaaa tgcatacagt caacggatac gtgaatcggt cactgcccgg     1560

gctcatcggt tgtcacagaa agtccgtgta ctggcacgtc atcggcatgg gcactacgcc     1620

tgaagtgcac tccatcttcc tggaagggca caccttcctc gtgcgcaacc accgccaggc     1680

ctctctggaa atctccccga ttacctttct gaccgcccag actctgctca tggacctggg     1740

gcagttcctt ctcttctgcc acatctccag ccatcagcac gacggaatgg aggcctacgt     1800

gaaggtggac tcatgcccgg aagaacctca gttgcggatg aagaacaacg aggaggccga     1860

ggactatgac gacgatttga ctgactccga gatggacgtc gtgcggttcg atgacgacaa     1920

cagccccagc ttcatccaga ttcgcagcgt ggccaagaag caccccaaaa cctgggtgca     1980

ctacatcgcg gccgaggaag aagattggga ctacgccccg ttggtgctgg cacccgatga     2040

ccggtcgtac aagtcccagt atctgaacaa tggtccgcag cggattggca gaaagtacaa     2100

gaaagtgcgg ttcatggcgt acactgacga aacgtttaag acccgggagg ccattcaaca     2160

tgagagcggc attctgggac cactgctgta cggagaggtc ggcgataccc tgctcatcat     2220

cttcaaaaac caggcctccc ggccttacaa catctaccct cacggaatca ccgacgtgcg     2280

gccactctac tcgcggcgcc tgccgaaggg cgtcaagcac ctgaaagact tccctatcct     2340

gccgggcgaa atcttcaagt ataagtggac cgtcaccgtg gaggacgggc ccaccaagag     2400

cgatcctagg tgtctgactc ggtactactc cagcttcgtg aacatggaac gggacctggc     2460

atcgggactc attggaccgc tgctgatctg ctacaaagag tcggtggatc aacgcggcaa     2520

ccagatcatg tccgacaagc gcaacgtgat cctgttctcc gtgtttgatg aaaacagatc     2580

ctggtacctc actgaaaaca tccagaggtt cctcccaaac cccgcaggag tgcaactgga     2640

ggaccctgag tttcaggcct cgaatatcat gcactcgatt aacggttacg tgttcgactc     2700

gctgcaactg agcgtgtgcc tccatgaagt cgcttactgg tacattctgt ccatcggcgc     2760

ccagactgac ttcctgagcg tgttcttttc cggttacacc tttaagcaca agatggtgta     2820

cgaagatacc ctgaccctgt tccctttctc cggcgaaacg gtgttcatgt cgatggagaa     2880

cccgggtctg tggattctgg gatgccacaa cagcgacttt cggaaccgcg gaatgactgc     2940

cctgctgaag gtgtcctcat gcgacaagaa caccggagac tactacgagg actcctacga     3000

ggatatctca gcctacctcc tgtccaagaa caacgcgatc gagccgcgca gcttcagcca     3060

gaacggcgcg ccaacatcag agagcgccac ccctgaaagt ggtcccggga gcgagccagc     3120

cacatctggg tcggaaacgc caggcacaag tgagtctgca actcccgagt ccggacctgg     3180

ctccgagcct gccactagcg gctccgagac tccgggaact tccgagagcg ctacaccaga     3240

aagcggaccc ggaaccagta ccgaacctag cgagggctct gctccgggca gcccagccgg     3300

ctctcctaca tccacggagg agggcacttc cgaatccgcc accccggagt cagggccagg     3360

atctgaaccc gctacctcag gcagtgagac gccaggaacg agcgagtccg ctacaccgga     3420

gagtgggcca gggagccctg ctggatctcc tacgtccact gaggaagggt caccagcggg     3480

ctcgcccacc agcactgaag aaggtgcctc gagcccgcct gtgctgaaga ggcaccagcg     3540

agaaattacc cggaccaccc tccaatcgga tcaggaggaa atcgactacg acgacaccat     3600

ctcggtggaa atgaagaagg aagatttcga tatctacgac gaggacgaaa atcagtcccc     3660

tcgctcattc caaaagaaaa ctagacacta ctttatcgcc gcggtggaaa gactgtggga     3720

ctatggaatg tcatccagcc ctcacgtcct tcggaaccgg gcccagagcg gatcggtgcc     3780

tcagttcaag aaagtggtgt tccaggagtt caccgacggc agcttcaccc agccgctgta     3840

ccggggagaa ctgaacgaac acctgggcct gctcggtccc tacatccgcg cggaagtgga     3900

ggataacatc atggtgacct tccgtaacca agcatccaga ccttactcct tctattcctc     3960

cctgatctca tacgaggagg accagcgcca aggcgccgag ccccgcaaga acttcgtcaa     4020

gcccaacgag actaagacct acttctggaa ggtccaacac catatggccc cgaccaagga     4080

tgagtttgac tgcaaggcct gggcctactt ctccgacgtg gaccttgaga aggatgtcca     4140

ttccggcctg atcgggccgc tgctcgtgtg tcacaccaac accctgaacc cagcgcatgg     4200

acgccaggtc accgtccagg agtttgctct gttcttcacc atttttgacg aaactaagtc     4260

ctggtacttc accgagaata tggagcgaaa ctgtagagcg ccctgcaata tccagatgga     4320

agatccgact ttcaaggaga actatagatt ccacgccatc aacgggtaca tcatggatac     4380

tctgccgggg ctggtcatgg cccaggatca gaggattcgg tggtacttgc tgtcaatggg     4440

atcgaacgaa aacattcact ccattcactt ctccggtcac gtgttcactg tgcgcaagaa     4500

ggaggagtac aagatggcgc tgtacaatct gtaccccggg gtgttcgaaa ctgtggagat     4560

gctgccgtcc aaggccggca tctggagagt ggagtgcctg atcggagagc acctccacgc     4620

ggggatgtcc accctcttcc tggtgtactc gaataagtgc cagaccccgc tgggcatggc     4680

ctcgggccac atcagagact tccagatcac agcaagcgga caatacggcc aatgggcgcc     4740

gaagctggcc cgcttgcact actccggatc gatcaacgca tggtccacca aggaaccgtt     4800

ctcgtggatt aaggtggacc tcctggcccc tatgattatc cacggaatta agacccaggg     4860

cgccaggcag aagttctcct ccctgtacat ctcgcaattc atcatcatgt acagcctgga     4920

cgggaagaag tggcagactt acaggggaaa ctccaccggc accctgatgg tctttttcgg     4980

caacgtggat tcctccggca ttaagcacaa catcttcaac ccaccgatca tagccagata     5040

tattaggctc caccccactc actactcaat ccgctcaact cttcggatgg aactcatggg     5100

gtgcgacctg aactcctgct ccatgccgtt ggggatggaa tcaaaggcta ttagcgacgc     5160

ccagatcacc gcgagctcct acttcactaa catgttcgcc acctggagcc cctccaaggc     5220

caggctgcac ttgcagggac ggtcaaatgc ctggcggccg caagtgaaca atccgaagga     5280

atggcttcaa gtggatttcc aaaagaccat gaaagtgacc ggagtcacca cccagggagt     5340

gaagtccctt ctgacctcga tgtatgtgaa ggagttcctg attagcagca gccaggacgg     5400

gcaccagtgg accctgttct tccaaaacgg aaaggtcaag gtgttccagg ggaaccagga     5460

ctcgttcaca cccgtggtga actccctgga ccccccactg ctgacgcggt acttgaggat     5520

tcatcctcag tcctgggtcc atcagattgc attgcgaatg gaagtcctgg gctgcgaggc     5580

ccaggacctg tactgaatca gcctgagctc gctgatcata atcaacctct ggattacaaa     5640

atttgtgaaa gattgactgg tattcttaac tatgttgctc cttttacgct atgtggatac     5700

gctgctttaa tgcctttgta tcatgctatt gcttcccgta tggctttcat tttctcctcc     5760

ttgtataaat cctggttgct gtctctttat gaggagttgt ggcccgttgt caggcaacgt     5820

ggcgtggtgt gcactgtgtt tgctgacgca acccccactg gttggggcat tgccaccacc     5880

tgtcagctcc tttccgggac tttcgctttc cccctcccta ttgccacggc ggaactcatc     5940

gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt tgggcactga caattccgtg     6000

gtgttgtcgg ggaaatcatc gtcctttcct tggctgctcg cctgtgttgc cacctggatt     6060

ctgcgcggga cgtccttctg ctacgtccct tcggccctca atccagcgga ccttccttcc     6120

cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc gccttcgccc tcagacgagt     6180

cggatctccc tttgggccgc ctccccgctg atcagcctcg actgtgcctt ctagttgcca     6240

gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac     6300

tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat     6360

tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca     6420

tgctggggat gcggtgggct ctatggcttc tgaggcggaa agaacgggct cgagaagctt     6480

ctagatatcc tctcttaagg tagcatcgag atttaaatta gggataacag ggtaatggcg     6540

cgggccgcca cttcctggcg cgcaaaatat cctcttgtcc ttgagtctca ttggagggtt     6600

cgttcgttcg aaccagccaa tcaggggagg gggaagtgac gcaagttccg gtcacatgct     6660

tccggtgacg cacatccggt gacgtagttc cggtcacgtg cttcctgtca cgtgtttccg     6720

gtcacgtgac ttccggtcat gtgacttccg gtgacgtgtt tccggcttaa ctattgggct     6780

gaccgcgcgg catgcgcgtg gtcaacctaa cagccggaaa cacgtcaccg                6830


<210>  183
<211>  282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' ITR

<400>  183
cggtgacgtg tttccggctg ttaggttgac cacgcgcatg ccgcgcggtc agcccaatag       60

ttaagccgga aacacgtcac cggaagtcac atgaccggaa gtcacgtgac cggaaacacg      120

tgacaggaag cacgtgaccg gaactacgtc accggatgtg cgtcaccgga agcatgtgac      180

cggaacttgc gtcacttccc cctcccctga ttggctggtt cgaacgaacg aaccctccaa      240

tgagactcaa ggacaagagg atattttgcg cgccaggaag tg                         282


<210>  184
<211>  282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' ITR inverted terminal repeat

<400>  184
cggtgacgtg tttccggctg ttaggttgac cacgcgcatg ccgcgcggtc agcccaatag       60

ttaagccgga aacacgtcac cggaagtcac atgaccggaa gtcacgtgac cggaaacacg      120

tgacaggaag cacgtgaccg gaactacgtc accggatgtg cgtcaccgga agcatgtgac      180

cggaacttgc gtcacttccc cctcccctga ttggctggtt cgaacgaacg aaccctccaa      240

tgagactcaa ggacaagagg atattttgcg cgccaggaag tg                         282


