                         SEQUENCE LISTING

<110>  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
 
<120>  HIGH AFFINITY ENGINEERED MATRIPTASE INHIBITOR

<130>  STAN-1436WO

<150>  US 62/549,376
<151>  2017-08-23

<150>  US 62/542,733
<151>  2017-08-08

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  54
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  1

Cys Val Asp Leu Pro Asp Thr Gly Arg Cys Arg Gly Ser Ile Pro Arg 
1               5                   10                  15      


Trp Tyr Tyr Asn Pro Phe Ser Glu His Cys Ala Arg Phe Thr Tyr Gly 
            20                  25                  30          


Gly Cys Tyr Gly Asn Lys Asn Asn Phe Glu Glu Glu Gln Gln Cys Leu 
        35                  40                  45              


Glu Ser Cys Arg Gly Ile 
    50                  


<210>  2
<211>  54
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  2

Cys Val Asp Leu Pro Asp Thr Gly Arg Cys Arg Gly Ser Phe Pro Arg 
1               5                   10                  15      


Trp Tyr Tyr Asp Pro Thr Glu Gln Ile Cys Lys Ser Phe Val Tyr Gly 
            20                  25                  30          


Gly Cys Leu Gly Asn Lys Asn Asn Tyr Leu Arg Glu Glu Glu Cys Ile 
        35                  40                  45              


Leu Ala Cys Arg Gly Val 
    50                  


<210>  3
<211>  54
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  3

Cys Leu Ala Ser Asn Lys Val Gly Arg Cys Arg Gly Ser Phe Pro Arg 
1               5                   10                  15      


Trp Tyr Tyr Asp Pro Thr Glu Gln Ile Cys Lys Ser Phe Val Tyr Gly 
            20                  25                  30          


Gly Cys Leu Gly Asn Lys Asn Asn Tyr Leu Arg Glu Glu Glu Cys Ile 
        35                  40                  45              


Leu Ala Cys Arg Gly Val 
    50                  


<210>  4
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  4

Cys Val Asp Leu Pro Asp Thr Gly Leu Cys Lys Glu Ser Ile Pro 
1               5                   10                  15  


<210>  5
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  5

Cys Val Asp Leu Pro Asp Thr Gly Arg Cys Arg Glu Ser Ile Pro 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  6

Cys Val Asp Leu Pro Asp Thr Gly Arg Cys Arg Gly Ser Ile Pro 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  7

Cys Leu Ala Ser Asn Lys Val Gly Arg Cys Arg Gly Ser Phe Pro 
1               5                   10                  15  


<210>  8
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  8

Ser Lys Leu Arg Val Val Gly Gly 
1               5               


<210>  9
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  9

Arg Ser Lys Leu Arg Val Val Gly Gly His 
1               5                   10  


<210>  10
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  10

Arg Arg Ser Lys Leu Arg Val Val Gly Gly His Pro 
1               5                   10          


<210>  11
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  11

Gln Arg Arg Ser Lys Leu Arg Val Val Gly Gly His Pro Gly 
1               5                   10                  


<210>  12
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  12

Asp Gln Arg Arg Ser Lys Leu Arg Val Val Gly Gly His Pro Gly Asn 
1               5                   10                  15      


<210>  13
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  13

Leu Asp Gln Arg Arg Ser Lys Leu Arg Val Val Gly Gly His Pro Gly 
1               5                   10                  15      


Asn Ser 
        


<210>  14
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  14

Arg Leu Asp Gln Arg Arg Ser Lys Leu Arg Val Val Gly Gly His Pro 
1               5                   10                  15      


Gly Asn Ser Pro 
            20  


<210>  15
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  15

Asp Arg Leu Asp Gln Arg Arg Ser Lys Leu Arg Val Val Gly Gly His 
1               5                   10                  15      


Pro Gly Asn Ser Pro Trp 
            20          


<210>  16
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  16

Arg Cys Arg Gly 
1               


<210>  17
<211>  640
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  17

Gly Pro Pro Pro Ala Pro Pro Gly Leu Pro Ala Gly Ala Asp Cys Leu 
1               5                   10                  15      


Asn Ser Phe Thr Ala Gly Val Pro Gly Phe Val Leu Asp Thr Asn Ala 
            20                  25                  30          


Ser Val Ser Asn Gly Ala Thr Phe Leu Glu Ser Pro Thr Val Arg Arg 
        35                  40                  45              


Gly Trp Asp Cys Val Arg Ala Cys Cys Thr Thr Gln Asn Cys Asn Leu 
    50                  55                  60                  


Ala Leu Val Glu Leu Gln Pro Asp Arg Gly Glu Asp Ala Ile Ala Ala 
65                  70                  75                  80  


Cys Phe Leu Ile Asn Cys Leu Tyr Glu Gln Asn Phe Val Cys Lys Phe 
                85                  90                  95      


Ala Pro Arg Glu Gly Phe Ile Asn Tyr Leu Thr Arg Glu Val Tyr Arg 
            100                 105                 110         


Ser Tyr Arg Gln Leu Arg Thr Gln Gly Phe Gly Gly Ser Gly Ile Pro 
        115                 120                 125             


Lys Ala Trp Ala Gly Ile Asp Leu Lys Val Gln Pro Gln Glu Pro Leu 
    130                 135                 140                 


Val Leu Lys Asp Val Glu Asn Thr Asp Trp Arg Leu Leu Arg Gly Asp 
145                 150                 155                 160 


Thr Asp Val Arg Val Glu Arg Lys Asp Pro Asn Gln Val Glu Leu Trp 
                165                 170                 175     


Gly Leu Lys Glu Gly Thr Tyr Leu Phe Gln Leu Thr Val Thr Ser Ser 
            180                 185                 190         


Asp His Pro Glu Asp Thr Ala Asn Val Thr Val Thr Val Leu Ser Thr 
        195                 200                 205             


Lys Gln Thr Glu Asp Tyr Cys Leu Ala Ser Asn Lys Val Gly Arg Cys 
    210                 215                 220                 


Arg Gly Ser Phe Pro Arg Trp Tyr Tyr Asp Pro Thr Glu Gln Ile Cys 
225                 230                 235                 240 


Lys Ser Phe Val Tyr Gly Gly Cys Leu Gly Asn Lys Asn Asn Tyr Leu 
                245                 250                 255     


Arg Glu Glu Glu Cys Ile Leu Ala Cys Arg Gly Val Gln Gly Pro Ser 
            260                 265                 270         


Met Glu Arg Arg His Pro Val Cys Ser Gly Thr Cys Gln Pro Thr Gln 
        275                 280                 285             


Phe Arg Cys Ser Asn Gly Cys Cys Ile Asp Ser Phe Leu Glu Cys Asp 
    290                 295                 300                 


Asp Thr Pro Asn Cys Pro Asp Ala Ser Asp Glu Ala Ala Cys Glu Lys 
305                 310                 315                 320 


Tyr Thr Ser Gly Phe Asp Glu Leu Gln Arg Ile His Phe Pro Ser Asp 
                325                 330                 335     


Lys Gly His Cys Val Asp Leu Pro Asp Thr Gly Arg Cys Arg Gly Ser 
            340                 345                 350         


Phe Pro Arg Trp Tyr Tyr Asp Pro Thr Glu Gln Ile Cys Lys Ser Phe 
        355                 360                 365             


Val Tyr Gly Gly Cys Leu Gly Asn Lys Asn Asn Tyr Leu Arg Glu Glu 
    370                 375                 380                 


Glu Cys Ile Leu Ala Cys Arg Gly Val Ser Lys Lys Asp Val Phe Gly 
385                 390                 395                 400 


Leu Arg Arg Glu Ile Pro Ile Pro Ser Thr Gly Ser Val Glu Asp Lys 
                405                 410                 415     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            420                 425                 430         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        435                 440                 445             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    450                 455                 460                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
465                 470                 475                 480 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                485                 490                 495     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            500                 505                 510         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        515                 520                 525             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    530                 535                 540                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
545                 550                 555                 560 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                565                 570                 575     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            580                 585                 590         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        595                 600                 605             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    610                 615                 620                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
625                 630                 635                 640 


<210>  18
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  18
gctatcttcg ctgctttgc                                                    19


<210>  19
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  19
tgtcagttcc tgcaagtctt ctt                                               23


<210>  20
<211>  650
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  20

Gly Pro Pro Pro Ala Pro Pro Gly Leu Pro Ala Gly Ala Asp Cys Leu 
1               5                   10                  15      


Asn Ser Phe Thr Ala Gly Val Pro Gly Phe Val Leu Asp Thr Asn Ala 
            20                  25                  30          


Ser Val Ser Asn Gly Ala Thr Phe Leu Glu Ser Pro Thr Val Arg Arg 
        35                  40                  45              


Gly Trp Asp Cys Val Arg Ala Cys Cys Thr Thr Gln Asn Cys Asn Leu 
    50                  55                  60                  


Ala Leu Val Glu Leu Gln Pro Asp Arg Gly Glu Asp Ala Ile Ala Ala 
65                  70                  75                  80  


Cys Phe Leu Ile Asn Cys Leu Tyr Glu Gln Asn Phe Val Cys Lys Phe 
                85                  90                  95      


Ala Pro Arg Glu Gly Phe Ile Asn Tyr Leu Thr Arg Glu Val Tyr Arg 
            100                 105                 110         


Ser Tyr Arg Gln Leu Arg Thr Gln Gly Phe Gly Gly Ser Gly Ile Pro 
        115                 120                 125             


Lys Ala Trp Ala Gly Ile Asp Leu Lys Val Gln Pro Gln Glu Pro Leu 
    130                 135                 140                 


Val Leu Lys Asp Val Glu Asn Thr Asp Trp Arg Leu Leu Arg Gly Asp 
145                 150                 155                 160 


Thr Asp Val Arg Val Glu Arg Lys Asp Pro Asn Gln Val Glu Leu Trp 
                165                 170                 175     


Gly Leu Lys Glu Gly Thr Tyr Leu Phe Gln Leu Thr Val Thr Ser Ser 
            180                 185                 190         


Asp His Pro Glu Asp Thr Ala Asn Val Thr Val Thr Val Leu Ser Thr 
        195                 200                 205             


Lys Gln Thr Glu Asp Tyr Cys Leu Ala Ser Asn Lys Val Gly Arg Cys 
    210                 215                 220                 


Arg Gly Ser Phe Pro Arg Trp Tyr Tyr Asp Pro Thr Glu Gln Ile Cys 
225                 230                 235                 240 


Lys Ser Phe Val Tyr Gly Gly Cys Leu Gly Asn Lys Asn Asn Tyr Leu 
                245                 250                 255     


Arg Glu Glu Glu Cys Ile Leu Ala Cys Arg Gly Val Gln Gly Pro Ser 
            260                 265                 270         


Met Glu Arg Arg His Pro Val Cys Ser Gly Thr Cys Gln Pro Thr Gln 
        275                 280                 285             


Phe Arg Cys Ser Asn Gly Cys Cys Ile Asp Ser Phe Leu Glu Cys Asp 
    290                 295                 300                 


Asp Thr Pro Asn Cys Pro Asp Ala Ser Asp Glu Ala Ala Cys Glu Lys 
305                 310                 315                 320 


Tyr Thr Ser Gly Phe Asp Glu Leu Gln Arg Ile His Phe Pro Ser Asp 
                325                 330                 335     


Lys Gly His Cys Val Asp Leu Pro Asp Thr Gly Arg Cys Arg Gly Ser 
            340                 345                 350         


Phe Pro Arg Trp Tyr Tyr Asp Pro Thr Glu Gln Ile Cys Lys Ser Phe 
        355                 360                 365             


Val Tyr Gly Gly Cys Leu Gly Asn Lys Asn Asn Tyr Leu Arg Glu Glu 
    370                 375                 380                 


Glu Cys Ile Leu Ala Cys Arg Gly Val Ser Lys Lys Asp Val Phe Gly 
385                 390                 395                 400 


Leu Arg Arg Glu Ile Pro Ile Pro Ser Thr Gly Ser Val Glu Ala Ala 
                405                 410                 415     


Ala Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
            420                 425                 430         


Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
        435                 440                 445             


Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
    450                 455                 460                 


Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
465                 470                 475                 480 


Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
                485                 490                 495     


Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
            500                 505                 510         


His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
        515                 520                 525             


Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
    530                 535                 540                 


Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
545                 550                 555                 560 


Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
                565                 570                 575     


Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
            580                 585                 590         


Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
        595                 600                 605             


Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
    610                 615                 620                 


Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
625                 630                 635                 640 


Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                645                 650 


<210>  21
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  21

Arg Ser Lys Leu Arg Val Gly Gly His 
1               5                   


