                         SEQUENCE LISTING

<110>  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
       GLAXOSMITHKLINE BIOLOGICALS S.A.
 
<120>  IMMUNOGENIC COMPOSITIONS COMPRISING CHIMERIC INFLUENZA VIRUS 
       HEMAGGLUTININ POLYPEPTIDES AND AS01 AND USES THEREOF

<130>  6923-274-228

<150>  US 62/542,143
<151>  2017-08-07

<160>  189   

<170>  PatentIn version 3.5

<210>  1
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary H1 HA

<400>  1

Met Lys Ala Asn Leu Leu Val Leu Leu Cys Ala Leu Ala Ala Ala Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Asp Pro Leu Leu Pro Val Arg Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Ser Glu Asn Gly Ile Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Asn 
    130                 135                 140                 


Thr Asn Gly Val Thr Ala Ala Cys Ser His Glu Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Glu Gly Ser Tyr Pro Lys 
                165                 170                 175     


Leu Lys Asn Ser Tyr Val Asn Lys Lys Gly Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Ile His His Pro Pro Asn Ser Lys Glu Gln Gln Asn Leu Tyr 
        195                 200                 205             


Gln Asn Glu Asn Ala Tyr Val Ser Val Val Thr Ser Asn Tyr Asn Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Arg Asp Gln Ala 
225                 230                 235                 240 


Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Lys Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Met Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser Met 
        275                 280                 285             


His Glu Cys Asn Thr Lys Cys Gln Thr Pro Leu Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Tyr Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Asn Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Thr Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Ile Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Val Asp Gly Val Lys Leu Glu Ser Met Gly Ile Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


Cys Arg Ile Cys Ile 
                565 


<210>  2
<211>  563
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary H2 HA

<400>  2

Met Ala Ile Ile Tyr Leu Ile Leu Leu Phe Thr Ala Val Arg Gly Asp 
1               5                   10                  15      


Gln Ile Cys Ile Gly Tyr His Ser Asn Asn Ser Thr Glu Lys Val Asp 
            20                  25                  30          


Thr Ile Leu Glu Arg Asn Val Thr Val Thr His Ala Gln Asn Ile Leu 
        35                  40                  45              


Glu Lys Thr His Asn Gly Lys Leu Cys Lys Leu Asn Gly Ile Pro Pro 
    50                  55                  60                  


Leu Glu Leu Gly Asp Cys Ser Ile Ala Gly Trp Leu Leu Gly Asn Pro 
65                  70                  75                  80  


Glu Cys Asp Arg Leu Leu Thr Val Pro Glu Trp Ser Tyr Ile Met Glu 
                85                  90                  95      


Lys Glu Asn Pro Arg Asn Gly Leu Cys Tyr Pro Gly Ser Phe Asn Asp 
            100                 105                 110         


Tyr Glu Glu Leu Lys His Leu Leu Ser Ser Val Thr His Phe Glu Lys 
        115                 120                 125             


Val Lys Ile Leu Pro Lys Asp Arg Trp Thr Gln His Thr Thr Thr Gly 
    130                 135                 140                 


Gly Ser Arg Ala Cys Ala Val Ser Gly Asn Pro Ser Phe Phe Arg Asn 
145                 150                 155                 160 


Met Val Trp Leu Thr Lys Lys Gly Ser Asn Tyr Pro Ile Ala Lys Gly 
                165                 170                 175     


Ser Tyr Asn Asn Thr Ser Gly Glu Gln Met Leu Ile Ile Trp Gly Val 
            180                 185                 190         


His His Pro Ser Asn Asp Glu Thr Glu Gln Arg Thr Leu Tyr Gln Asn 
        195                 200                 205             


Val Gly Thr Tyr Val Ser Ile Gly Thr Ser Thr Leu Asn Lys Arg Ser 
    210                 215                 220                 


Ile Pro Val Ile Ala Thr Arg Pro Lys Val Asn Gly Gln Gly Gly Arg 
225                 230                 235                 240 


Met Glu Phe Ser Trp Thr Ile Leu Asp Ile Trp Asp Thr Ile Asn Phe 
                245                 250                 255     


Glu Ser Thr Gly Asn Leu Ile Ala Pro Glu Tyr Gly Phe Arg Ile Ser 
            260                 265                 270         


Lys Arg Gly Ser Ser Gly Ile Met Lys Thr Glu Gly Thr Leu Glu Asn 
        275                 280                 285             


Cys Glu Thr Lys Cys Gln Thr Pro Leu Gly Ala Ile Asn Thr Thr Leu 
    290                 295                 300                 


Pro Phe His Asn Val His Pro Leu Thr Ile Gly Glu Cys Pro Lys Tyr 
305                 310                 315                 320 


Val Lys Ser Glu Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Val Pro 
                325                 330                 335     


Gln Ile Glu Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu 
            340                 345                 350         


Gly Gly Trp Gln Gly Met Ile Asp Gly Trp Tyr Gly Tyr His His Ser 
        355                 360                 365             


Asn Asp Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln Lys 
    370                 375                 380                 


Ala Ile Asp Gly Ile Thr Asn Arg Val Asn Ser Val Ile Glu Lys Met 
385                 390                 395                 400 


Asn Thr Gln Phe Glu Ala Val Gly Lys Glu Phe Ser Asn Leu Glu Lys 
                405                 410                 415     


Arg Leu Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp Val 
            420                 425                 430         


Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg Thr 
        435                 440                 445             


Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Arg Val Arg 
    450                 455                 460                 


Met Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe Glu 
465                 470                 475                 480 


Phe Tyr His Lys Cys Asp Asp Glu Cys Met Asn Ser Val Lys Asn Gly 
                485                 490                 495     


Thr Tyr Asp Tyr Pro Lys Tyr Glu Glu Glu Ser Lys Leu Asn Arg Asn 
            500                 505                 510         


Glu Ile Lys Gly Val Lys Leu Ser Asn Met Gly Val Tyr Gln Ile Leu 
        515                 520                 525             


Ala Ile Tyr Ala Thr Val Ala Gly Ser Leu Ser Leu Ala Ile Met Ile 
    530                 535                 540                 


Ala Gly Ile Ser Leu Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg 
545                 550                 555                 560 


Ile Cys Ile 
            


<210>  3
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary H3 HA

<400>  3

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Ala Leu Gly 
1               5                   10                  15      


Gln Asp Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asp Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Lys Ile Cys Asn Asn Pro His Arg Ile Leu Asp Gly Ile Asp Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp Val Phe Gln 
                85                  90                  95      


Asn Glu Thr Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Phe Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Ile Thr Glu Gly Phe Thr Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Gly Ser Asn Ala Cys Lys Arg Gly Pro Gly 
145                 150                 155                 160 


Asn Gly Phe Phe Ser Arg Leu Asn Trp Leu Thr Lys Ser Gly Ser Thr 
                165                 170                 175     


Tyr Pro Val Leu Asn Val Thr Met Pro Asn Asn Asp Asn Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asn Gln Glu Gln Thr 
        195                 200                 205             


Ser Leu Tyr Val Gln Glu Ser Gly Arg Val Thr Val Ser Thr Arg Arg 
    210                 215                 220                 


Ser Gln Gln Ser Ile Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg 
225                 230                 235                 240 


Gly Gln Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Val Leu Val Ile Asn Ser Asn Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Met Arg Thr Gly Lys Ser Ser Ile Met Ser Ser Asp Ala 
        275                 280                 285             


Pro Ile Asp Thr Cys Ile Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Lys Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Leu Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Ile Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Val 
385                 390                 395                 400 


Ile Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Arg Arg Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Glu Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Arg Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  4
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary H4 HA

<400>  4

Met Leu Ser Ile Val Ile Leu Phe Leu Leu Ile Ala Glu Asn Ser Ser 
1               5                   10                  15      


Gln Asn Tyr Thr Gly Asn Pro Val Ile Cys Met Gly His His Ala Val 
            20                  25                  30          


Ala Asn Gly Thr Met Val Lys Thr Leu Ala Asp Asp Gln Val Glu Val 
        35                  40                  45              


Val Thr Ala Gln Glu Leu Val Glu Ser Gln Asn Leu Pro Glu Leu Cys 
    50                  55                  60                  


Pro Ser Pro Leu Arg Leu Val Asp Gly Gln Thr Cys Asp Ile Ile Asn 
65                  70                  75                  80  


Gly Ala Leu Gly Ser Pro Gly Cys Asp His Leu Asn Gly Ala Glu Trp 
                85                  90                  95      


Asp Val Phe Ile Glu Arg Pro Asn Ala Val Asp Thr Cys Tyr Pro Phe 
            100                 105                 110         


Asp Val Pro Glu Tyr Gln Ser Leu Arg Ser Ile Leu Ala Asn Asn Gly 
        115                 120                 125             


Lys Phe Glu Phe Ile Ala Glu Glu Phe Gln Trp Asn Thr Val Lys Gln 
    130                 135                 140                 


Asn Gly Lys Ser Gly Ala Cys Lys Arg Ala Asn Val Asp Asp Phe Phe 
145                 150                 155                 160 


Asn Arg Leu Asn Trp Leu Val Lys Ser Asp Gly Asn Ala Tyr Pro Leu 
                165                 170                 175     


Gln Asn Leu Thr Lys Ile Asn Asn Gly Asp Tyr Ala Arg Leu Tyr Ile 
            180                 185                 190         


Trp Gly Val His His Pro Ser Thr Ser Thr Glu Gln Thr Asn Leu Tyr 
        195                 200                 205             


Lys Asn Asn Pro Gly Arg Val Thr Val Ser Thr Lys Thr Ser Gln Thr 
    210                 215                 220                 


Ser Val Val Pro Asp Ile Gly Ser Arg Pro Leu Val Arg Gly Gln Ser 
225                 230                 235                 240 


Gly Arg Val Ser Phe Tyr Trp Thr Ile Val Glu Pro Gly Asp Leu Ile 
                245                 250                 255     


Val Phe Asn Thr Ile Gly Asn Leu Ile Ala Pro Arg Gly His Tyr Lys 
            260                 265                 270         


Leu Asn Asn Gln Lys Lys Ser Thr Ile Leu Asn Thr Ala Ile Pro Ile 
        275                 280                 285             


Gly Ser Cys Val Ser Lys Cys His Thr Asp Lys Gly Ser Leu Ser Thr 
    290                 295                 300                 


Thr Lys Pro Phe Gln Asn Ile Ser Arg Ile Ala Val Gly Asp Cys Pro 
305                 310                 315                 320 


Arg Tyr Val Lys Gln Gly Ser Leu Lys Leu Ala Thr Gly Met Arg Asn 
                325                 330                 335     


Ile Pro Glu Lys Ala Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Asn Gly Trp Gln Gly Leu Ile Asp Gly Trp Tyr Gly Phe Arg 
        355                 360                 365             


His Gln Asn Ala Glu Gly Thr Gly Thr Ala Ala Asp Leu Lys Ser Thr 
    370                 375                 380                 


Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu Ile Glu 
385                 390                 395                 400 


Lys Thr Asn Asp Lys Tyr His Gln Ile Glu Lys Glu Phe Glu Gln Val 
                405                 410                 415     


Glu Gly Arg Ile Gln Asp Leu Glu Asn Tyr Val Glu Asp Thr Lys Ile 
            420                 425                 430         


Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu Asn Gln 
        435                 440                 445             


His Thr Ile Asp Val Thr Asp Ser Glu Met Asn Lys Leu Phe Glu Arg 
    450                 455                 460                 


Val Arg Arg Gln Leu Arg Glu Asn Ala Glu Asp Lys Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Ile Phe His Lys Cys Asp Asn Asn Cys Ile Glu Ser Ile Arg 
                485                 490                 495     


Asn Gly Thr Tyr Asp His Asp Ile Tyr Arg Asp Glu Ala Ile Asn Asn 
            500                 505                 510         


Arg Phe Gln Ile Gln Gly Val Lys Leu Thr Gln Gly Tyr Lys Asp Ile 
        515                 520                 525             


Ile Leu Trp Ile Ser Phe Ser Ile Ser Cys Phe Leu Leu Val Ala Leu 
    530                 535                 540                 


Leu Leu Ala Phe Ile Leu Trp Ala Cys Gln Asn Gly Asn Ile Arg Cys 
545                 550                 555                 560 


Gln Ile Cys Ile 
                


<210>  5
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary H5 HA

<400>  5

Met Glu Arg Ile Val Leu Leu Leu Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Lys Ser Thr Lys Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Arg Thr His Asn Gly Lys Leu Cys Ser Leu Asn Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Leu Asn Leu Pro Glu Trp Leu Tyr Ile Val 
                85                  90                  95      


Glu Lys Asp Asn Pro Ile Asn Ser Leu Cys Tyr Pro Gly Asp Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys Tyr Leu Leu Ser Ser Thr Asn His Phe Glu 
        115                 120                 125             


Lys Ile Arg Ile Ile Pro Arg Ser Ser Trp Ser Asn His Asp Ala Ser 
    130                 135                 140                 


Ser Gly Val Ser Ser Ala Cys Pro Tyr Ile Gly Arg Ser Ser Phe Leu 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Asn Thr Tyr Pro Thr Ile 
                165                 170                 175     


Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Ile Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr Gln 
        195                 200                 205             


Asn Pro Thr Thr Tyr Val Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Ser Ile Pro Glu Ile Ala Thr Arg Pro Lys Val Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Arg Tyr Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Ala Ile Met Lys Ser Gly Leu Ala Tyr Gly 
        275                 280                 285             


Asn Cys Asp Thr Lys Cys Gln Thr Pro Val Gly Glu Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro His Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asp Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Val 
                325                 330                 335     


Pro Gln Arg Lys Lys Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
            340                 345                 350         


Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His 
        355                 360                 365             


Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln 
    370                 375                 380                 


Lys Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Ile Ile Asp Lys 
385                 390                 395                 400 


Met Asn Thr Arg Phe Glu Ala Val Gly Lys Glu Phe Asn Asn Leu Glu 
                405                 410                 415     


Arg Arg Val Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp 
            420                 425                 430         


Val Trp Thr Tyr Asn Val Glu Leu Leu Val Leu Met Glu Asn Glu Arg 
        435                 440                 445             


Thr Leu Asp Phe His Asp Ser Asn Val Asn Asn Leu Tyr Asp Lys Val 
    450                 455                 460                 


Arg Leu Gln Leu Lys Asp Asn Ala Arg Glu Leu Gly Asn Gly Cys Phe 
465                 470                 475                 480 


Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg Asn 
                485                 490                 495     


Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala Arg Leu Asn Arg 
            500                 505                 510         


Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln Ile 
        515                 520                 525             


Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala Leu Ala Ile Met 
    530                 535                 540                 


Ile Ala Gly Leu Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln Cys 
545                 550                 555                 560 


Arg Ile Cys Ile 
                


<210>  6
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary H6 HA

<400>  6

Met Ile Ala Ile Ile Val Val Ala Ile Leu Ala Thr Ala Gly Arg Ser 
1               5                   10                  15      


Asp Lys Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Thr Gln Ile 
            20                  25                  30          


Asp Thr Ile Leu Glu Lys Asn Val Thr Val Thr His Ser Val Glu Leu 
        35                  40                  45              


Leu Glu Asn Gln Lys Glu Glu Arg Phe Cys Lys Ile Leu Lys Lys Ala 
    50                  55                  60                  


Pro Leu Asp Leu Lys Gly Cys Thr Ile Glu Gly Trp Ile Leu Gly Asn 
65                  70                  75                  80  


Pro Gln Cys Asp Leu Leu Leu Gly Asp Gln Ser Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Arg Pro Thr Ala Gln Asn Gly Ile Cys Tyr Pro Gly Val Leu Asn 
            100                 105                 110         


Glu Val Glu Glu Leu Lys Ala Leu Ile Gly Ser Gly Glu Arg Val Glu 
        115                 120                 125             


Arg Phe Glu Met Phe Pro Lys Ser Thr Trp Thr Gly Val Asp Thr Ser 
    130                 135                 140                 


Ser Gly Val Thr Arg Ala Cys Pro Tyr Asn Ser Gly Ser Ser Phe Tyr 
145                 150                 155                 160 


Arg Asn Leu Leu Trp Ile Ile Lys Thr Lys Ser Ala Ala Tyr Ser Val 
                165                 170                 175     


Ile Lys Gly Ala Tyr Asn Asn Thr Gly Asn Gln Pro Ile Leu Tyr Phe 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asp Thr Asn Glu Gln Asn Thr Leu Tyr 
        195                 200                 205             


Gly Ser Gly Asp Arg Tyr Val Arg Met Gly Thr Glu Ser Met Asn Phe 
    210                 215                 220                 


Ala Lys Ser Pro Glu Ile Ala Ala Arg Pro Ala Val Asn Gly Gln Arg 
225                 230                 235                 240 


Gly Arg Ile Asp Tyr Tyr Trp Ser Ile Leu Lys Pro Gly Glu Thr Leu 
                245                 250                 255     


Asn Val Glu Ser Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Arg 
            260                 265                 270         


Phe Val Ser Thr Ser Asn Lys Gly Ala Val Phe Lys Ser Asn Leu Pro 
        275                 280                 285             


Ile Glu Asn Cys Asp Ala Thr Cys Gln Thr Val Ala Gly Val Leu Arg 
    290                 295                 300                 


Thr Asn Lys Thr Phe Gln Asn Val Ser Pro Leu Trp Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Glu Ser Leu Arg Leu Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Val Pro Gln Ile Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Glu Asn Ser Gln Gly Ser Gly Tyr Ala Ala Asp Arg Glu Ser 
    370                 375                 380                 


Thr Gln Lys Ala Val Asp Gly Ile Thr Asn Lys Val Asn Ser Ile Ile 
385                 390                 395                 400 


Asp Lys Met Asn Thr Gln Phe Glu Ala Val Asp His Glu Phe Ser Asn 
                405                 410                 415     


Leu Glu Arg Arg Ile Asp Asn Leu Asn Lys Arg Met Glu Asp Gly Phe 
            420                 425                 430         


Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Leu His Asp Ala Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Arg Val Lys Ser Gln Leu Arg Asp Asn Ala Met Ile Leu Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Trp His Lys Cys Asp Asp Glu Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Gln Asp Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Gln Glu Ile Glu Ser Val Lys Leu Glu Ser Leu Gly Val Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ser Ser Ser Leu Val Leu Val 
    530                 535                 540                 


Gly Leu Ile Ile Ala Val Gly Leu Trp Met Cys Ser Asn Gly Ser Met 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210>  7
<211>  563
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary H7 HA

<400>  7

Met Asn Thr Gln Ile Leu Val Phe Ala Leu Val Ala Val Ile Pro Thr 
1               5                   10                  15      


Asn Ala Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly Thr 
            20                  25                  30          


Lys Val Asn Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn Ala Thr 
        35                  40                  45              


Glu Thr Val Glu Arg Thr Asn Ile Pro Lys Ile Cys Ser Lys Gly Lys 
    50                  55                  60                  


Arg Thr Thr Asp Leu Gly Gln Cys Gly Leu Leu Gly Thr Ile Thr Gly 
65                  70                  75                  80  


Pro Pro Gln Cys Asp Gln Phe Leu Glu Phe Ser Ala Asp Leu Ile Ile 
                85                  90                  95      


Glu Arg Arg Glu Gly Asn Asp Val Cys Tyr Pro Gly Lys Phe Val Asn 
            100                 105                 110         


Glu Glu Ala Leu Arg Gln Ile Leu Arg Gly Ser Gly Gly Ile Asp Lys 
        115                 120                 125             


Glu Thr Met Gly Phe Thr Tyr Ser Gly Ile Arg Thr Asn Gly Thr Thr 
    130                 135                 140                 


Ser Ala Cys Arg Arg Ser Gly Ser Ser Phe Tyr Ala Glu Met Glu Trp 
145                 150                 155                 160 


Leu Leu Ser Asn Thr Asp Asn Ala Ser Phe Pro Gln Met Thr Lys Ser 
                165                 170                 175     


Tyr Lys Asn Thr Arg Arg Glu Ser Ala Leu Ile Val Trp Gly Ile His 
            180                 185                 190         


His Ser Gly Ser Thr Thr Glu Gln Thr Lys Leu Tyr Gly Ser Gly Asn 
        195                 200                 205             


Lys Leu Ile Thr Val Gly Ser Ser Lys Tyr His Gln Ser Phe Val Pro 
    210                 215                 220                 


Ser Pro Gly Thr Arg Pro Gln Ile Asn Gly Gln Ser Gly Arg Ile Asp 
225                 230                 235                 240 


Phe His Trp Leu Ile Leu Asp Pro Asn Asp Thr Val Thr Phe Ser Phe 
                245                 250                 255     


Asn Gly Ala Phe Ile Ala Pro Asn Arg Ala Ser Phe Leu Arg Gly Lys 
            260                 265                 270         


Ser Met Gly Ile Gln Ser Asp Val Gln Val Asp Ala Asn Cys Glu Gly 
        275                 280                 285             


Glu Cys Tyr His Ser Gly Gly Thr Ile Thr Ser Arg Leu Pro Phe Gln 
    290                 295                 300                 


Asn Ile Asn Ser Arg Ala Val Gly Lys Cys Pro Arg Tyr Val Lys Gln 
305                 310                 315                 320 


Glu Ser Leu Leu Leu Ala Thr Gly Met Lys Asn Val Pro Glu Pro Ser 
                325                 330                 335     


Lys Lys Arg Lys Lys Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
            340                 345                 350         


Glu Asn Gly Trp Glu Gly Leu Val Asp Gly Trp Tyr Gly Phe Arg His 
        355                 360                 365             


Gln Asn Ala Gln Gly Glu Gly Thr Ala Ala Asp Tyr Lys Ser Thr Gln 
    370                 375                 380                 


Ser Ala Ile Asp Gln Ile Thr Gly Lys Leu Asn Arg Leu Ile Glu Lys 
385                 390                 395                 400 


Thr Asn Gln Gln Phe Glu Leu Ile Asp Asn Glu Phe Thr Glu Val Glu 
                405                 410                 415     


Lys Gln Ile Gly Asn Leu Ile Asn Trp Thr Lys Asp Ser Ile Thr Glu 
            420                 425                 430         


Val Trp Ser Tyr Asn Ala Glu Leu Ile Val Ala Met Glu Asn Gln His 
        435                 440                 445             


Thr Ile Asp Leu Ala Asp Ser Glu Met Asn Arg Leu Tyr Glu Arg Val 
    450                 455                 460                 


Arg Lys Gln Leu Arg Glu Asn Ala Glu Glu Asp Gly Thr Gly Cys Phe 
465                 470                 475                 480 


Glu Ile Phe His Lys Cys Asp Asp Asp Cys Met Ala Ser Ile Arg Asn 
                485                 490                 495     


Asn Thr Tyr Asp His Ser Lys Tyr Arg Glu Glu Ala Met Gln Asn Arg 
            500                 505                 510         


Ile Gln Ile Asp Pro Val Lys Leu Ser Ser Gly Tyr Lys Asp Val Ile 
        515                 520                 525             


Leu Trp Phe Ser Phe Gly Ala Ser Cys Phe Leu Leu Leu Ala Ile Ala 
    530                 535                 540                 


Met Gly Leu Val Phe Ile Cys Val Lys Asn Gly Asn Met Arg Cys Thr 
545                 550                 555                 560 


Ile Cys Ile 
            


<210>  8
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary H8 HA

<400>  8

Met Glu Lys Phe Ile Ala Ile Ala Thr Leu Ala Ser Thr Asn Ala Tyr 
1               5                   10                  15      


Asp Arg Ile Cys Ile Gly Tyr Gln Ser Asn Asn Ser Thr Asp Thr Val 
            20                  25                  30          


Asn Thr Leu Ile Glu Gln Asn Val Pro Val Thr Gln Thr Met Glu Leu 
        35                  40                  45              


Val Glu Thr Glu Lys His Pro Ala Tyr Cys Asn Thr Asp Leu Gly Ala 
    50                  55                  60                  


Pro Leu Glu Leu Arg Asp Cys Lys Ile Glu Ala Val Ile Tyr Gly Asn 
65                  70                  75                  80  


Pro Lys Cys Asp Ile His Leu Lys Asp Gln Gly Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Arg Pro Ser Ala Pro Glu Gly Met Cys Tyr Pro Gly Ser Val Glu 
            100                 105                 110         


Asn Leu Glu Glu Leu Arg Phe Val Phe Ser Ser Ala Ala Ser Tyr Lys 
        115                 120                 125             


Arg Ile Arg Leu Phe Asp Tyr Ser Arg Trp Asn Val Thr Arg Ser Gly 
    130                 135                 140                 


Thr Ser Lys Ala Cys Asn Ala Ser Thr Gly Gly Gln Ser Phe Tyr Arg 
145                 150                 155                 160 


Ser Ile Asn Trp Leu Thr Lys Lys Glu Pro Asp Thr Tyr Asp Phe Asn 
                165                 170                 175     


Glu Gly Ala Tyr Val Asn Asn Glu Asp Gly Asp Ile Ile Phe Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Pro Asp Thr Lys Glu Gln Thr Thr Leu Tyr Lys 
        195                 200                 205             


Asn Ala Asn Thr Leu Ser Ser Val Thr Thr Asn Thr Ile Asn Arg Ser 
    210                 215                 220                 


Phe Gln Pro Asn Ile Gly Pro Arg Pro Leu Val Arg Gly Gln Gln Gly 
225                 230                 235                 240 


Arg Met Asp Tyr Tyr Trp Gly Ile Leu Lys Arg Gly Glu Thr Leu Lys 
                245                 250                 255     


Ile Arg Thr Asn Gly Asn Leu Ile Ala Pro Glu Phe Gly Tyr Leu Leu 
            260                 265                 270         


Lys Gly Glu Ser Tyr Gly Arg Ile Ile Gln Asn Glu Asp Ile Pro Ile 
        275                 280                 285             


Gly Asn Cys Asn Thr Lys Cys Gln Thr Tyr Ala Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Lys Pro Phe Gln Asn Ala Ser Arg His Tyr Met Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Lys Lys Ala Ser Leu Arg Leu Ala Val Gly Leu Arg Asn 
                325                 330                 335     


Thr Pro Ser Val Glu Pro Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Ser Gly Met Ile Asp Gly Trp Tyr Gly Phe His 
        355                 360                 365             


His Ser Asn Ser Glu Gly Thr Gly Met Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Glu Ala Ile Asp Lys Ile Thr Asn Lys Val Asn Asn Ile Val Asp 
385                 390                 395                 400 


Lys Met Asn Arg Glu Phe Glu Val Val Asn His Glu Phe Ser Glu Val 
                405                 410                 415     


Glu Lys Arg Ile Asn Met Ile Asn Asp Lys Ile Asp Asp Gln Ile Glu 
            420                 425                 430         


Asp Leu Trp Ala Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Gln 
        435                 440                 445             


Lys Thr Leu Asp Glu His Asp Ser Asn Val Lys Asn Leu Phe Asp Glu 
    450                 455                 460                 


Val Lys Arg Arg Leu Ser Ala Asn Ala Ile Asp Ala Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Asp Ile Leu His Lys Cys Asp Asn Glu Cys Met Glu Thr Ile Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp His Lys Glu Tyr Glu Glu Glu Ala Lys Leu Glu 
            500                 505                 510         


Arg Ser Lys Ile Asn Gly Val Lys Leu Glu Glu Asn Thr Thr Tyr Lys 
        515                 520                 525             


Ile Leu Ser Ile Tyr Ser Thr Val Ala Ala Ser Leu Cys Leu Ala Ile 
    530                 535                 540                 


Leu Ile Ala Gly Gly Leu Ile Leu Gly Met Gln Asn Gly Ser Cys Arg 
545                 550                 555                 560 


Cys Met Phe Cys Ile 
                565 


<210>  9
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary H9 HA

<400>  9

Met Glu Thr Lys Ala Ile Ile Ala Ala Leu Leu Met Val Thr Ala Ala 
1               5                   10                  15      


Asn Ala Asp Lys Ile Cys Ile Gly Tyr Gln Ser Thr Asn Ser Thr Glu 
            20                  25                  30          


Thr Val Asp Thr Leu Thr Glu Ser Asn Val Pro Val Thr His Thr Lys 
        35                  40                  45              


Glu Leu Leu His Thr Glu His Asn Gly Met Leu Cys Ala Thr Asp Leu 
    50                  55                  60                  


Gly His Pro Leu Ile Leu Asp Thr Cys Thr Ile Glu Gly Leu Ile Tyr 
65                  70                  75                  80  


Gly Asn Pro Ser Cys Asp Ile Leu Leu Gly Gly Lys Glu Trp Ser Tyr 
                85                  90                  95      


Ile Val Glu Arg Ser Ser Ala Val Asn Gly Met Cys Tyr Pro Gly Asn 
            100                 105                 110         


Val Glu Asn Leu Glu Glu Leu Arg Ser Leu Phe Ser Ser Ala Lys Ser 
        115                 120                 125             


Tyr Lys Arg Ile Gln Ile Phe Pro Asp Lys Thr Trp Asn Val Thr Tyr 
    130                 135                 140                 


Ser Gly Thr Ser Arg Ala Cys Ser Asn Ser Phe Tyr Arg Ser Met Arg 
145                 150                 155                 160 


Trp Leu Thr His Lys Ser Asn Ser Tyr Pro Phe Gln Asn Ala His Tyr 
                165                 170                 175     


Thr Asn Asn Glu Arg Glu Asn Ile Leu Phe Met Trp Gly Ile His His 
            180                 185                 190         


Pro Pro Thr Asp Thr Glu Gln Thr Asp Leu Tyr Lys Asn Ala Asp Thr 
        195                 200                 205             


Thr Thr Ser Val Thr Thr Glu Asp Ile Asn Arg Thr Phe Lys Pro Val 
    210                 215                 220                 


Ile Gly Pro Arg Pro Leu Val Asn Gly Gln Gln Gly Arg Ile Asp Tyr 
225                 230                 235                 240 


Tyr Trp Ser Val Leu Lys Pro Gly Gln Thr Leu Arg Ile Arg Ser Asn 
                245                 250                 255     


Gly Asn Leu Ile Ala Pro Trp Tyr Gly His Val Leu Thr Gly Glu Ser 
            260                 265                 270         


His Gly Arg Ile Leu Lys Thr Asp Leu Asn Asn Gly Asn Cys Val Val 
        275                 280                 285             


Gln Cys Gln Thr Glu Lys Gly Gly Leu Asn Thr Thr Leu Pro Phe His 
    290                 295                 300                 


Asn Ile Ser Lys Tyr Ala Phe Gly Asn Cys Pro Lys Tyr Val Gly Val 
305                 310                 315                 320 


Lys Ser Leu Lys Leu Pro Val Gly Leu Arg Asn Val Pro Ala Val Ser 
                325                 330                 335     


Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp 
            340                 345                 350         


Pro Gly Leu Val Ala Gly Trp Tyr Gly Phe Gln His Ser Asn Asp Gln 
        355                 360                 365             


Gly Val Gly Met Ala Ala Asp Lys Gly Ser Thr Gln Lys Ala Ile Asp 
    370                 375                 380                 


Lys Ile Thr Ser Lys Val Asn Asn Ile Ile Asp Lys Met Asn Lys Gln 
385                 390                 395                 400 


Tyr Glu Val Ile Asp His Glu Phe Asn Glu Leu Glu Ala Arg Leu Asn 
                405                 410                 415     


Met Ile Asn Asn Lys Ile Asp Asp Gln Ile Gln Asp Ile Trp Ala Tyr 
            420                 425                 430         


Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Gln Lys Thr Leu Asp Glu 
        435                 440                 445             


His Asp Ala Asn Val Asn Asn Leu Tyr Asn Lys Val Lys Arg Ala Leu 
    450                 455                 460                 


Gly Ser Asn Ala Val Glu Asp Gly Asn Gly Cys Phe Glu Leu Tyr His 
465                 470                 475                 480 


Lys Cys Asp Asp Gln Cys Met Glu Thr Ile Arg Asn Gly Thr Tyr Asp 
                485                 490                 495     


Arg Gln Lys Tyr Gln Glu Glu Ser Arg Leu Glu Arg Gln Lys Ile Glu 
            500                 505                 510         


Gly Val Lys Leu Glu Ser Glu Gly Thr Tyr Lys Ile Leu Thr Ile Tyr 
        515                 520                 525             


Ser Thr Val Ala Ser Ser Leu Val Leu Ala Met Gly Phe Ala Ala Phe 
    530                 535                 540                 


Leu Phe Trp Ala Met Ser Asn Gly Ser Cys Arg Cys Asn Ile Cys Ile 
545                 550                 555                 560 


<210>  10
<211>  561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary H10 HA

<400>  10

Met Tyr Lys Val Val Val Ile Ile Ala Leu Leu Gly Ala Val Lys Gly 
1               5                   10                  15      


Leu Asp Arg Ile Cys Leu Gly His His Ala Val Ala Asn Gly Thr Ile 
            20                  25                  30          


Val Lys Thr Leu Thr Asn Glu Gln Glu Glu Val Thr Asn Ala Thr Glu 
        35                  40                  45              


Thr Val Glu Ser Thr Asn Leu Asn Lys Leu Cys Met Lys Gly Arg Ser 
    50                  55                  60                  


Tyr Lys Asp Leu Gly Asn Cys His Pro Val Gly Met Leu Ile Gly Thr 
65                  70                  75                  80  


Pro Val Cys Asp Pro His Leu Thr Gly Thr Trp Asp Thr Leu Ile Glu 
                85                  90                  95      


Arg Glu Asn Ala Ile Ala His Cys Tyr Pro Gly Ala Thr Ile Asn Glu 
            100                 105                 110         


Glu Ala Leu Arg Gln Lys Ile Met Glu Ser Gly Gly Ile Ser Lys Met 
        115                 120                 125             


Ser Thr Gly Phe Thr Tyr Gly Ser Ser Ile Thr Ser Ala Gly Thr Thr 
    130                 135                 140                 


Lys Ala Cys Met Arg Asn Gly Gly Asp Ser Phe Tyr Ala Glu Leu Lys 
145                 150                 155                 160 


Trp Leu Val Ser Lys Thr Lys Gly Gln Asn Phe Pro Gln Thr Thr Asn 
                165                 170                 175     


Thr Tyr Arg Asn Thr Asp Thr Ala Glu His Leu Ile Ile Trp Gly Ile 
            180                 185                 190         


His His Pro Ser Ser Thr Gln Glu Lys Asn Asp Leu Tyr Gly Thr Gln 
        195                 200                 205             


Ser Leu Ser Ile Ser Val Glu Ser Ser Thr Tyr Gln Asn Asn Phe Val 
    210                 215                 220                 


Pro Val Val Gly Ala Arg Pro Gln Val Asn Gly Gln Ser Gly Arg Ile 
225                 230                 235                 240 


Asp Phe His Trp Thr Leu Val Gln Pro Gly Asp Asn Ile Thr Phe Ser 
                245                 250                 255     


Asp Asn Gly Gly Leu Ile Ala Pro Ser Arg Val Ser Lys Leu Thr Gly 
            260                 265                 270         


Arg Asp Leu Gly Ile Gln Ser Glu Ala Leu Ile Asp Asn Ser Cys Glu 
        275                 280                 285             


Ser Lys Cys Phe Trp Arg Gly Gly Ser Ile Asn Thr Lys Leu Pro Phe 
    290                 295                 300                 


Gln Asn Leu Ser Pro Arg Thr Val Gly Gln Cys Pro Lys Tyr Val Asn 
305                 310                 315                 320 


Gln Arg Ser Leu Leu Leu Ala Thr Gly Met Arg Asn Val Pro Glu Val 
                325                 330                 335     


Val Gln Gly Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn 
            340                 345                 350         


Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn 
        355                 360                 365             


Ala Gln Gly Thr Gly Gln Ala Ala Asp Tyr Lys Ser Thr Gln Ala Ala 
    370                 375                 380                 


Ile Asp Gln Ile Thr Gly Lys Leu Asn Arg Leu Ile Glu Lys Thr Asn 
385                 390                 395                 400 


Thr Glu Phe Glu Ser Ile Glu Ser Glu Phe Ser Glu Thr Glu His Gln 
                405                 410                 415     


Ile Gly Asn Val Ile Asn Trp Thr Lys Asp Ser Ile Thr Asp Ile Trp 
            420                 425                 430         


Thr Tyr Asn Ala Glu Leu Leu Val Ala Met Glu Asn Gln His Thr Ile 
        435                 440                 445             


Asp Met Ala Asp Ser Glu Met Leu Asn Leu Tyr Glu Arg Val Arg Lys 
    450                 455                 460                 


Gln Leu Arg Gln Asn Ala Glu Glu Asp Gly Lys Gly Cys Phe Glu Ile 
465                 470                 475                 480 


Tyr His Thr Cys Asp Asp Ser Cys Met Glu Ser Ile Arg Asn Asn Thr 
                485                 490                 495     


Tyr Asp His Ser Gln Tyr Arg Glu Glu Ala Leu Leu Asn Arg Leu Asn 
            500                 505                 510         


Ile Asn Pro Val Lys Leu Ser Ser Gly Tyr Lys Asp Ile Ile Leu Trp 
        515                 520                 525             


Phe Ser Phe Gly Glu Ser Cys Phe Val Leu Leu Ala Val Val Met Gly 
    530                 535                 540                 


Leu Val Phe Phe Cys Leu Lys Asn Gly Asn Met Arg Cys Thr Ile Cys 
545                 550                 555                 560 


Ile 
    


<210>  11
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary H11 HA

<400>  11

Met Glu Lys Thr Leu Leu Phe Ala Ala Ile Phe Leu Cys Val Lys Ala 
1               5                   10                  15      


Asp Glu Ile Cys Ile Gly Tyr Leu Ser Asn Asn Ser Thr Asp Lys Val 
            20                  25                  30          


Asp Thr Ile Ile Glu Asn Asn Val Thr Val Thr Ser Ser Val Glu Leu 
        35                  40                  45              


Val Glu Thr Glu His Thr Gly Ser Phe Cys Ser Ile Asn Gly Lys Gln 
    50                  55                  60                  


Pro Ile Ser Leu Gly Asp Cys Ser Phe Ala Gly Trp Ile Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Leu Ile Gly Lys Thr Ser Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Pro Asn Pro Thr Asn Gly Ile Cys Tyr Pro Gly Thr Leu Glu 
            100                 105                 110         


Ser Glu Glu Glu Leu Arg Leu Lys Phe Ser Gly Val Leu Glu Phe Asn 
        115                 120                 125             


Lys Phe Glu Val Phe Thr Ser Asn Gly Trp Gly Ala Val Asn Ser Gly 
    130                 135                 140                 


Val Gly Val Thr Ala Ala Cys Lys Phe Gly Gly Ser Asn Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Met Val Trp Leu Ile His Gln Ser Gly Thr Tyr Pro Val Ile 
                165                 170                 175     


Lys Arg Thr Phe Asn Asn Thr Lys Gly Arg Asp Val Leu Ile Val Trp 
            180                 185                 190         


Gly Ile His His Pro Ala Thr Leu Thr Glu His Gln Asp Leu Tyr Lys 
        195                 200                 205             


Lys Asp Ser Ser Tyr Val Ala Val Gly Ser Glu Thr Tyr Asn Arg Arg 
    210                 215                 220                 


Phe Thr Pro Glu Ile Asn Thr Arg Pro Arg Val Asn Gly Gln Ala Gly 
225                 230                 235                 240 


Arg Met Thr Phe Tyr Trp Lys Ile Val Lys Pro Gly Glu Ser Ile Thr 
                245                 250                 255     


Phe Glu Ser Asn Gly Ala Phe Leu Ala Pro Arg Tyr Ala Phe Glu Ile 
            260                 265                 270         


Val Ser Val Gly Asn Gly Lys Leu Phe Arg Ser Glu Leu Asn Ile Glu 
        275                 280                 285             


Ser Cys Ser Thr Lys Cys Gln Thr Glu Ile Gly Gly Ile Asn Thr Asn 
    290                 295                 300                 


Lys Ser Phe His Asn Val His Arg Asn Thr Ile Gly Asp Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Asn Val Lys Ser Leu Lys Leu Ala Thr Gly Pro Arg Asn Val 
                325                 330                 335     


Pro Ala Ile Ala Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
            340                 345                 350         


Glu Gly Gly Trp Pro Gly Leu Ile Asn Gly Trp Tyr Gly Phe Gln His 
        355                 360                 365             


Arg Asp Glu Glu Gly Thr Gly Ile Ala Ala Asp Lys Glu Ser Thr Gln 
    370                 375                 380                 


Lys Ala Ile Asp Gln Ile Thr Ser Lys Val Asn Asn Ile Val Asp Arg 
385                 390                 395                 400 


Met Asn Thr Asn Phe Glu Ser Val Gln His Glu Phe Ser Glu Ile Glu 
                405                 410                 415     


Glu Arg Ile Asn Gln Leu Ser Lys His Val Asp Asp Ser Val Val Asp 
            420                 425                 430         


Ile Trp Ser Tyr Asn Ala Gln Leu Leu Val Leu Leu Glu Asn Glu Lys 
        435                 440                 445             


Thr Leu Asp Leu His Asp Ser Asn Val Arg Asn Leu His Glu Lys Val 
    450                 455                 460                 


Arg Arg Met Leu Lys Asp Asn Ala Lys Asp Glu Gly Asn Gly Cys Phe 
465                 470                 475                 480 


Thr Phe Tyr His Lys Cys Asp Asn Lys Cys Ile Glu Arg Val Arg Asn 
                485                 490                 495     


Gly Thr Tyr Asp His Lys Glu Phe Glu Glu Glu Ser Lys Ile Asn Arg 
            500                 505                 510         


Gln Glu Ile Glu Gly Val Lys Leu Asp Ser Ser Gly Asn Val Tyr Lys 
        515                 520                 525             


Ile Leu Ser Ile Tyr Ser Cys Ile Ala Ser Ser Leu Val Leu Ala Ala 
    530                 535                 540                 


Leu Ile Met Gly Phe Met Phe Trp Ala Cys Ser Asn Gly Ser Cys Arg 
545                 550                 555                 560 


Cys Thr Ile Cys Ile 
                565 


<210>  12
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary H12 HA

<400>  12

Met Glu Lys Phe Ile Ile Leu Ser Thr Val Leu Ala Ala Ser Phe Ala 
1               5                   10                  15      


Tyr Asp Lys Ile Cys Ile Gly Tyr Gln Thr Asn Asn Ser Thr Glu Thr 
            20                  25                  30          


Val Asn Thr Leu Ser Glu Gln Asn Val Pro Val Thr Gln Val Glu Glu 
        35                  40                  45              


Leu Val His Arg Gly Ile Asp Pro Ile Leu Cys Gly Thr Glu Leu Gly 
    50                  55                  60                  


Ser Pro Leu Val Leu Asp Asp Cys Ser Leu Glu Gly Leu Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Lys Cys Asp Leu Tyr Leu Asn Gly Arg Glu Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Arg Pro Lys Glu Met Glu Gly Val Cys Tyr Pro Gly Ser Ile 
            100                 105                 110         


Glu Asn Gln Glu Glu Leu Arg Ser Leu Phe Ser Ser Ile Lys Lys Tyr 
        115                 120                 125             


Glu Arg Val Lys Met Phe Asp Phe Thr Lys Trp Asn Val Thr Tyr Thr 
    130                 135                 140                 


Gly Thr Ser Lys Ala Cys Asn Asn Thr Ser Asn Gln Gly Ser Phe Tyr 
145                 150                 155                 160 


Arg Ser Met Arg Trp Leu Thr Leu Lys Ser Gly Gln Phe Pro Val Gln 
                165                 170                 175     


Thr Asp Glu Tyr Lys Asn Thr Arg Asp Ser Asp Ile Val Phe Thr Trp 
            180                 185                 190         


Ala Ile His His Pro Pro Thr Ser Asp Glu Gln Val Lys Leu Tyr Lys 
        195                 200                 205             


Asn Pro Asp Thr Leu Ser Ser Val Thr Thr Val Glu Ile Asn Arg Ser 
    210                 215                 220                 


Phe Lys Pro Asn Ile Gly Pro Arg Pro Leu Val Arg Gly Gln Gln Gly 
225                 230                 235                 240 


Arg Met Asp Tyr Tyr Trp Ala Val Leu Lys Pro Gly Gln Thr Val Lys 
                245                 250                 255     


Ile Gln Thr Asn Gly Asn Leu Ile Ala Pro Glu Tyr Gly His Leu Ile 
            260                 265                 270         


Thr Gly Lys Ser His Gly Arg Ile Leu Lys Asn Asn Leu Pro Met Gly 
        275                 280                 285             


Gln Cys Val Thr Glu Cys Gln Leu Asn Glu Gly Val Met Asn Thr Ser 
    290                 295                 300                 


Lys Pro Phe Gln Asn Thr Ser Lys His Tyr Ile Gly Lys Cys Pro Lys 
305                 310                 315                 320 


Tyr Ile Pro Ser Gly Ser Leu Lys Leu Ala Ile Gly Leu Arg Asn Val 
                325                 330                 335     


Pro Gln Val Gln Asp Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
            340                 345                 350         


Glu Gly Gly Trp Pro Gly Leu Val Ala Gly Trp Tyr Gly Phe Gln His 
        355                 360                 365             


Gln Asn Ala Glu Gly Thr Gly Ile Ala Ala Asp Arg Asp Ser Thr Gln 
    370                 375                 380                 


Arg Ala Ile Asp Asn Met Gln Asn Lys Leu Asn Asn Val Ile Asp Lys 
385                 390                 395                 400 


Met Asn Lys Gln Phe Glu Val Val Asn His Glu Phe Ser Glu Val Glu 
                405                 410                 415     


Ser Arg Ile Asn Met Ile Asn Ser Lys Ile Asp Asp Gln Ile Thr Asp 
            420                 425                 430         


Ile Trp Ala Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Gln Lys 
        435                 440                 445             


Thr Leu Asp Glu His Asp Ala Asn Val Arg Asn Leu His Asp Arg Val 
    450                 455                 460                 


Arg Arg Val Leu Arg Glu Asn Ala Ile Asp Thr Gly Asp Gly Cys Phe 
465                 470                 475                 480 


Glu Ile Leu His Lys Cys Asp Asn Asn Cys Met Asp Thr Ile Arg Asn 
                485                 490                 495     


Gly Thr Tyr Asn His Lys Glu Tyr Glu Glu Glu Ser Lys Ile Glu Arg 
            500                 505                 510         


Gln Lys Val Asn Gly Val Lys Leu Glu Glu Asn Ser Thr Tyr Lys Ile 
        515                 520                 525             


Leu Ser Ile Tyr Ser Ser Val Ala Ser Ser Leu Val Leu Leu Leu Met 
    530                 535                 540                 


Ile Ile Gly Gly Phe Ile Phe Gly Cys Gln Asn Gly Asn Val Arg Cys 
545                 550                 555                 560 


Thr Phe Cys Ile 
                


<210>  13
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary H13 HA

<400>  13

Met Ala Leu Asn Val Ile Ala Thr Leu Thr Leu Ile Ser Val Cys Val 
1               5                   10                  15      


His Ala Asp Arg Ile Cys Val Gly Tyr Leu Ser Thr Asn Ser Ser Glu 
            20                  25                  30          


Arg Val Asp Thr Leu Leu Glu Asn Gly Val Pro Val Thr Ser Ser Ile 
        35                  40                  45              


Asp Leu Ile Glu Thr Asn His Thr Gly Thr Tyr Cys Ser Leu Asn Gly 
    50                  55                  60                  


Val Ser Pro Val His Leu Gly Asp Cys Ser Phe Glu Gly Trp Ile Val 
65                  70                  75                  80  


Gly Asn Pro Ala Cys Thr Ser Asn Phe Gly Ile Arg Glu Trp Ser Tyr 
                85                  90                  95      


Leu Ile Glu Asp Pro Ala Ala Pro His Gly Leu Cys Tyr Pro Gly Glu 
            100                 105                 110         


Leu Asn Asn Asn Gly Glu Leu Arg His Leu Phe Ser Gly Ile Arg Ser 
        115                 120                 125             


Phe Ser Arg Thr Glu Leu Ile Pro Pro Thr Ser Trp Gly Glu Val Leu 
    130                 135                 140                 


Asp Gly Thr Thr Ser Ala Cys Arg Asp Asn Thr Gly Thr Asn Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Val Trp Phe Ile Lys Lys Asn Thr Arg Tyr Pro Val 
                165                 170                 175     


Ile Ser Lys Thr Tyr Asn Asn Thr Thr Gly Arg Asp Val Leu Val Leu 
            180                 185                 190         


Trp Gly Ile His His Pro Val Ser Val Asp Glu Thr Lys Thr Leu Tyr 
        195                 200                 205             


Val Asn Ser Asp Pro Tyr Thr Leu Val Ser Thr Lys Ser Trp Ser Glu 
    210                 215                 220                 


Lys Tyr Lys Leu Glu Thr Gly Val Arg Pro Gly Tyr Asn Gly Gln Arg 
225                 230                 235                 240 


Ser Trp Met Lys Ile Tyr Trp Ser Leu Ile His Pro Gly Glu Met Ile 
                245                 250                 255     


Thr Phe Glu Ser Asn Gly Gly Phe Leu Ala Pro Arg Tyr Gly Tyr Ile 
            260                 265                 270         


Ile Glu Glu Tyr Gly Lys Gly Arg Ile Phe Gln Ser Arg Ile Arg Met 
        275                 280                 285             


Ser Arg Cys Asn Thr Lys Cys Gln Thr Ser Val Gly Gly Ile Asn Thr 
    290                 295                 300                 


Asn Arg Thr Phe Gln Asn Ile Asp Lys Asn Ala Leu Gly Asp Cys Pro 
305                 310                 315                 320 


Lys Tyr Ile Lys Ser Gly Gln Leu Lys Leu Ala Thr Gly Leu Arg Asn 
                325                 330                 335     


Val Pro Ala Ile Ser Asn Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Pro Gly Leu Ile Asn Gly Trp Tyr Gly Phe Gln 
        355                 360                 365             


His Gln Asn Glu Gln Gly Thr Gly Ile Ala Ala Asp Lys Glu Ser Thr 
    370                 375                 380                 


Gln Lys Ala Ile Asp Gln Ile Thr Thr Lys Ile Asn Asn Ile Ile Asp 
385                 390                 395                 400 


Lys Met Asn Gly Asn Tyr Asp Ser Ile Arg Gly Glu Phe Asn Gln Val 
                405                 410                 415     


Glu Lys Arg Ile Asn Met Leu Ala Asp Arg Ile Asp Asp Ala Val Thr 
            420                 425                 430         


Asp Ile Trp Ser Tyr Asn Ala Lys Leu Leu Val Leu Leu Glu Asn Asp 
        435                 440                 445             


Lys Thr Leu Asp Met His Asp Ala Asn Val Lys Asn Leu His Glu Gln 
    450                 455                 460                 


Val Arg Arg Glu Leu Lys Asp Asn Ala Ile Asp Glu Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Leu Leu His Lys Cys Asn Asp Ser Cys Met Glu Thr Ile Arg 
                485                 490                 495     


Asn Gly Thr Tyr Asp His Thr Glu Tyr Ala Glu Glu Ser Lys Leu Lys 
            500                 505                 510         


Arg Gln Glu Ile Asp Gly Ile Lys Leu Lys Ser Glu Asp Asn Val Tyr 
        515                 520                 525             


Lys Ala Leu Ser Ile Tyr Ser Cys Ile Ala Ser Ser Val Val Leu Val 
    530                 535                 540                 


Gly Leu Ile Leu Ser Phe Ile Met Trp Ala Cys Ser Ser Gly Asn Cys 
545                 550                 555                 560 


Arg Phe Asn Val Cys Ile 
                565     


<210>  14
<211>  568
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary H14 HA

<400>  14

Met Ile Ala Leu Ile Leu Val Ala Leu Ala Leu Ser His Thr Ala Tyr 
1               5                   10                  15      


Ser Gln Ile Thr Asn Gly Thr Thr Gly Asn Pro Ile Ile Cys Leu Gly 
            20                  25                  30          


His His Ala Val Glu Asn Gly Thr Ser Val Lys Thr Leu Thr Asp Asn 
        35                  40                  45              


His Val Glu Val Val Ser Ala Lys Glu Leu Val Glu Thr Asn His Thr 
    50                  55                  60                  


Asp Glu Leu Cys Pro Ser Pro Leu Lys Leu Val Asp Gly Gln Asp Cys 
65                  70                  75                  80  


His Leu Ile Asn Gly Ala Leu Gly Ser Pro Gly Cys Asp Arg Leu Gln 
                85                  90                  95      


Asp Thr Thr Trp Asp Val Phe Ile Glu Arg Pro Thr Ala Val Asp Thr 
            100                 105                 110         


Cys Tyr Pro Phe Asp Val Pro Asp Tyr Gln Ser Leu Arg Ser Ile Leu 
        115                 120                 125             


Ala Ser Ser Gly Ser Leu Glu Phe Ile Ala Glu Gln Phe Thr Trp Asn 
    130                 135                 140                 


Gly Val Lys Val Asp Gly Ser Ser Ser Ala Cys Leu Arg Gly Gly Arg 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr Lys Ala Thr Asn Gly 
                165                 170                 175     


Asn Tyr Gly Pro Ile Asn Val Thr Lys Glu Asn Thr Gly Ser Tyr Val 
            180                 185                 190         


Arg Leu Tyr Leu Trp Gly Val His His Pro Ser Ser Asp Asn Glu Gln 
        195                 200                 205             


Thr Asp Leu Tyr Lys Val Ala Thr Gly Arg Val Thr Val Ser Thr Arg 
    210                 215                 220                 


Ser Asp Gln Ile Ser Ile Val Pro Asn Ile Gly Ser Arg Pro Arg Val 
225                 230                 235                 240 


Arg Asn Gln Ser Gly Arg Ile Ser Ile Tyr Trp Thr Leu Val Asn Pro 
                245                 250                 255     


Gly Asp Ser Ile Ile Phe Asn Ser Ile Gly Asn Leu Ile Ala Pro Arg 
            260                 265                 270         


Gly His Tyr Lys Ile Ser Lys Ser Thr Lys Ser Thr Val Leu Lys Ser 
        275                 280                 285             


Asp Lys Arg Ile Gly Ser Cys Thr Ser Pro Cys Leu Thr Asp Lys Gly 
    290                 295                 300                 


Ser Ile Gln Ser Asp Lys Pro Phe Gln Asn Val Ser Arg Ile Ala Ile 
305                 310                 315                 320 


Gly Asn Cys Pro Lys Tyr Val Lys Gln Gly Ser Leu Met Leu Ala Thr 
                325                 330                 335     


Gly Met Arg Asn Ile Pro Gly Lys Gln Ala Lys Gly Leu Phe Gly Ala 
            340                 345                 350         


Ile Ala Gly Phe Ile Glu Asn Gly Trp Gln Gly Leu Ile Asp Gly Trp 
        355                 360                 365             


Tyr Gly Phe Arg His Gln Asn Ala Glu Gly Thr Gly Thr Ala Ala Asp 
    370                 375                 380                 


Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn 
385                 390                 395                 400 


Arg Leu Ile Glu Lys Thr Asn Glu Lys Tyr His Gln Ile Glu Lys Glu 
                405                 410                 415     


Phe Glu Gln Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu 
            420                 425                 430         


Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala 
        435                 440                 445             


Leu Glu Asn Gln His Thr Ile Asp Val Thr Asp Ser Glu Met Asn Lys 
    450                 455                 460                 


Leu Phe Glu Arg Val Arg Arg Gln Leu Arg Glu Asn Ala Glu Asp Gln 
465                 470                 475                 480 


Gly Asn Gly Cys Phe Glu Ile Phe His Gln Cys Asp Asn Asn Cys Ile 
                485                 490                 495     


Glu Ser Ile Arg Asn Gly Thr Tyr Asp His Asn Ile Tyr Arg Asp Glu 
            500                 505                 510         


Ala Ile Asn Asn Arg Ile Lys Ile Asn Pro Val Thr Leu Thr Met Gly 
        515                 520                 525             


Tyr Lys Asp Ile Ile Leu Trp Ile Ser Phe Ser Met Ser Cys Phe Val 
    530                 535                 540                 


Phe Val Ala Leu Ile Leu Gly Phe Val Leu Trp Ala Cys Gln Asn Gly 
545                 550                 555                 560 


Asn Ile Arg Cys Gln Ile Cys Ile 
                565             


<210>  15
<211>  570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary H15 HA

<400>  15

Met Asn Thr Gln Ile Ile Val Ile Leu Val Leu Gly Leu Ser Met Val 
1               5                   10                  15      


Lys Ser Asp Lys Ile Cys Leu Gly His His Ala Val Ala Asn Gly Thr 
            20                  25                  30          


Lys Val Asn Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn Ala Thr 
        35                  40                  45              


Glu Thr Val Glu Ile Thr Gly Ile Asp Lys Val Cys Thr Lys Gly Lys 
    50                  55                  60                  


Lys Ala Val Asp Leu Gly Ser Cys Gly Ile Leu Gly Thr Ile Ile Gly 
65                  70                  75                  80  


Pro Pro Gln Cys Asp Leu His Leu Glu Phe Lys Ala Asp Leu Ile Ile 
                85                  90                  95      


Glu Arg Arg Asn Ser Ser Asp Ile Cys Tyr Pro Gly Arg Phe Thr Asn 
            100                 105                 110         


Glu Glu Ala Leu Arg Gln Ile Ile Arg Glu Ser Gly Gly Ile Asp Lys 
        115                 120                 125             


Glu Ser Met Gly Phe Arg Tyr Ser Gly Ile Arg Thr Asp Gly Ala Thr 
    130                 135                 140                 


Ser Ala Cys Lys Arg Thr Val Ser Ser Phe Tyr Ser Glu Met Lys Trp 
145                 150                 155                 160 


Leu Ser Ser Ser Met Asn Asn Gln Val Phe Pro Gln Leu Asn Gln Thr 
                165                 170                 175     


Tyr Arg Asn Thr Arg Lys Glu Pro Ala Leu Ile Val Trp Gly Val His 
            180                 185                 190         


His Ser Ser Ser Leu Asp Glu Gln Asn Lys Leu Tyr Gly Thr Gly Asn 
        195                 200                 205             


Lys Leu Ile Thr Val Gly Ser Ser Lys Tyr Gln Gln Ser Phe Ser Pro 
    210                 215                 220                 


Ser Pro Gly Ala Arg Pro Lys Val Asn Gly Gln Ala Gly Arg Ile Asp 
225                 230                 235                 240 


Phe His Trp Met Leu Leu Asp Pro Gly Asp Thr Val Thr Phe Thr Phe 
                245                 250                 255     


Asn Gly Ala Phe Ile Ala Pro Asp Arg Ala Thr Phe Leu Arg Ser Asn 
            260                 265                 270         


Ala Pro Ser Gly Ile Glu Tyr Asn Gly Lys Ser Leu Gly Ile Gln Ser 
        275                 280                 285             


Asp Ala Gln Ile Asp Glu Ser Cys Glu Gly Glu Cys Phe Tyr Ser Gly 
    290                 295                 300                 


Gly Thr Ile Asn Ser Pro Leu Pro Phe Gln Asn Ile Asp Ser Arg Ala 
305                 310                 315                 320 


Val Gly Lys Cys Pro Arg Tyr Val Lys Gln Ser Ser Leu Pro Leu Ala 
                325                 330                 335     


Leu Gly Met Lys Asn Val Pro Glu Lys Ile Arg Thr Arg Gly Leu Phe 
            340                 345                 350         


Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Leu Ile Asp 
        355                 360                 365             


Gly Trp Tyr Gly Phe Arg His Gln Asn Ala Gln Gly Gln Gly Thr Ala 
    370                 375                 380                 


Ala Asp Tyr Lys Ser Thr Gln Ala Ala Ile Asp Gln Ile Thr Gly Lys 
385                 390                 395                 400 


Leu Asn Arg Leu Ile Glu Lys Thr Asn Lys Gln Phe Glu Leu Ile Asp 
                405                 410                 415     


Asn Glu Phe Thr Glu Val Glu Gln Gln Ile Gly Asn Val Ile Asn Trp 
            420                 425                 430         


Thr Arg Asp Ser Leu Thr Glu Ile Trp Ser Tyr Asn Ala Glu Leu Leu 
        435                 440                 445             


Val Ala Met Glu Asn Gln His Thr Ile Asp Leu Ala Asp Ser Glu Met 
    450                 455                 460                 


Asn Lys Leu Tyr Glu Arg Val Arg Arg Gln Leu Arg Glu Asn Ala Glu 
465                 470                 475                 480 


Glu Asp Gly Thr Gly Cys Phe Glu Ile Phe His Arg Cys Asp Asp Gln 
                485                 490                 495     


Cys Met Glu Ser Ile Arg Asn Asn Thr Tyr Asn His Thr Glu Tyr Arg 
            500                 505                 510         


Gln Glu Ala Leu Gln Asn Arg Ile Met Ile Asn Pro Val Lys Leu Ser 
        515                 520                 525             


Ser Gly Tyr Lys Asp Val Ile Leu Trp Phe Ser Phe Gly Ala Ser Cys 
    530                 535                 540                 


Val Met Leu Leu Ala Ile Ala Met Gly Leu Ile Phe Met Cys Val Lys 
545                 550                 555                 560 


Asn Gly Asn Leu Arg Cys Thr Ile Cys Ile 
                565                 570 


<210>  16
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary H16 HA

<400>  16

Met Met Ile Lys Val Leu Tyr Phe Leu Ile Ile Val Leu Gly Arg Tyr 
1               5                   10                  15      


Ser Lys Ala Asp Lys Ile Cys Ile Gly Tyr Leu Ser Asn Asn Ser Ser 
            20                  25                  30          


Asp Thr Val Asp Thr Leu Thr Glu Asn Gly Val Pro Val Thr Ser Ser 
        35                  40                  45              


Val Asp Leu Val Glu Thr Asn His Thr Gly Thr Tyr Cys Ser Leu Asn 
    50                  55                  60                  


Gly Ile Ser Pro Ile His Leu Gly Asp Cys Ser Phe Glu Gly Trp Ile 
65                  70                  75                  80  


Val Gly Asn Pro Ser Cys Ala Thr Asn Ile Asn Ile Arg Glu Trp Ser 
                85                  90                  95      


Tyr Leu Ile Glu Asp Pro Asn Ala Pro Asn Lys Phe Cys Tyr Pro Gly 
            100                 105                 110         


Glu Leu Asp Asn Asn Gly Glu Leu Arg His Leu Phe Ser Gly Val Asn 
        115                 120                 125             


Ser Phe Ser Arg Thr Glu Leu Ile Asn Pro Ser Lys Trp Gly Asn Val 
    130                 135                 140                 


Leu Asp Gly Val Thr Ala Ser Cys Leu Asp Arg Gly Ala Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Val Trp Ile Val Lys Lys Asp Glu Lys Tyr Pro Val 
                165                 170                 175     


Ile Lys Gly Asp Tyr Asn Asn Thr Thr Gly Arg Asp Val Leu Val Leu 
            180                 185                 190         


Trp Gly Ile His His Pro Asp Thr Glu Thr Thr Ala Thr Asn Leu Tyr 
        195                 200                 205             


Val Asn Lys Asn Pro Tyr Thr Leu Val Ser Thr Lys Glu Trp Ser Lys 
    210                 215                 220                 


Arg Tyr Glu Leu Glu Ile Gly Thr Arg Ile Gly Asp Gly Gln Arg Ser 
225                 230                 235                 240 


Trp Met Lys Leu Tyr Trp His Leu Met His Pro Gly Glu Arg Ile Met 
                245                 250                 255     


Phe Glu Ser Asn Gly Gly Leu Ile Ala Pro Arg Tyr Gly Tyr Ile Ile 
            260                 265                 270         


Glu Lys Tyr Gly Thr Gly Arg Ile Phe Gln Ser Gly Val Arg Met Ala 
        275                 280                 285             


Arg Cys Asn Thr Lys Cys Gln Thr Ser Leu Gly Gly Ile Asn Thr Asn 
    290                 295                 300                 


Lys Thr Phe Gln Asn Ile Glu Arg Asn Ala Leu Gly Asp Cys Pro Lys 
305                 310                 315                 320 


Tyr Ile Lys Ser Gly Gln Leu Lys Leu Ala Thr Gly Leu Arg Asn Val 
                325                 330                 335     


Pro Ser Ile Gly Glu Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
            340                 345                 350         


Glu Gly Gly Trp Pro Gly Leu Ile Asn Gly Trp Tyr Gly Phe Gln His 
        355                 360                 365             


Gln Asn Glu Gln Gly Thr Gly Ile Ala Ala Asp Lys Ala Ser Thr Gln 
    370                 375                 380                 


Lys Ala Ile Asn Glu Ile Thr Thr Lys Ile Asn Asn Ile Ile Glu Lys 
385                 390                 395                 400 


Met Asn Gly Asn Tyr Asp Ser Ile Arg Gly Glu Phe Asn Gln Val Glu 
                405                 410                 415     


Lys Arg Ile Asn Met Leu Ala Asp Arg Val Asp Asp Ala Val Thr Asp 
            420                 425                 430         


Ile Trp Ser Tyr Asn Ala Lys Leu Leu Val Leu Leu Glu Asn Asp Arg 
        435                 440                 445             


Thr Leu Asp Leu His Asp Ala Asn Val Arg Asn Leu His Asp Gln Val 
    450                 455                 460                 


Lys Arg Ala Leu Lys Ser Asn Ala Ile Asp Glu Gly Asp Gly Cys Phe 
465                 470                 475                 480 


Asn Leu Leu His Lys Cys Asn Asp Ser Cys Met Glu Thr Ile Arg Asn 
                485                 490                 495     


Gly Thr Tyr Asn His Glu Asp Tyr Arg Glu Glu Ser Gln Leu Lys Arg 
            500                 505                 510         


Gln Glu Ile Glu Gly Ile Lys Leu Lys Thr Glu Asp Asn Val Tyr Lys 
        515                 520                 525             


Val Leu Ser Ile Tyr Ser Cys Ile Ala Ser Ser Ile Val Leu Val Gly 
    530                 535                 540                 


Leu Ile Leu Ala Phe Ile Met Trp Ala Cys Ser Asn Gly Ser Cys Arg 
545                 550                 555                 560 


Phe Asn Val Cys Ile 
                565 


<210>  17
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary H17 HA

<400>  17

Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Gln 
        35                  40                  45              


Thr Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp 
    50                  55                  60                  


Val Ala Leu Gly Arg Pro Lys Cys Met Gly Thr Ile Pro Ser Ala Lys 
65                  70                  75                  80  


Ala Ser Ile Leu His Glu Val Lys Pro Val Thr Ser Gly Cys Phe Pro 
                85                  90                  95      


Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg 
            100                 105                 110         


Gly Tyr Glu Asn Ile Arg Leu Ser Ala Arg Asn Val Thr Asn Ala Glu 
        115                 120                 125             


Thr Ala Pro Gly Gly Pro Tyr Ile Val Gly Thr Ser Gly Ser Cys Pro 
    130                 135                 140                 


Asn Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val 
145                 150                 155                 160 


Pro Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Val Glu Val Pro Tyr 
                165                 170                 175     


Ile Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser 
            180                 185                 190         


Asp Asp Glu Thr Gln Met Val Lys Leu Tyr Gly Asp Ser Lys Pro Gln 
        195                 200                 205             


Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln 
    210                 215                 220                 


Ile Gly Gly Phe Pro Asn Gln Ala Glu Asp Glu Gly Leu Pro Gln Ser 
225                 230                 235                 240 


Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr Gly 
                245                 250                 255     


Thr Ile Ala Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp Cys 
            260                 265                 270         


Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly 
        275                 280                 285             


Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys 
    290                 295                 300                 


Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile 
305                 310                 315                 320 


Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro 
                325                 330                 335     


Pro Ala Lys Leu Leu Lys 
            340         


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA subtype H1 signal peptide

<400>  18

Met Lys Ala Asn Leu Leu Val Leu Leu Cys Ala Leu Ala Ala Ala Asp 
1               5                   10                  15      


Ala 
    


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA subtype H2 signal peptide

<400>  19

Met Ala Ile Ile Tyr Leu Ile Leu Leu Phe Thr Ala Val Arg Gly 
1               5                   10                  15  


<210>  20
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA subtype H3 signal peptide

<400>  20

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Ala Leu Gly 
1               5                   10                  15      


<210>  21
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA subtype H4 signal peptide

<400>  21

Met Leu Ser Ile Val Ile Leu Phe Leu Leu Ile Ala Glu Asn Ser Ser 
1               5                   10                  15      


<210>  22
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA subtype H5 signal peptide

<400>  22

Met Leu Ser Ile Val Ile Leu Phe Leu Leu Ile Ala Glu Asn Ser Ser 
1               5                   10                  15      


<210>  23
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA subtype H6 signal peptide

<400>  23

Met Ile Ala Ile Ile Val Val Ala Ile Leu Ala Thr Ala Gly Arg Ser 
1               5                   10                  15      


<210>  24
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA subtype H7 signal peptide

<400>  24

Met Asn Thr Gln Ile Leu Val Phe Ala Leu Val Ala Val Ile Pro Thr 
1               5                   10                  15      


Asn Ala 
        


<210>  25
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA subtype H8 signal peptide

<400>  25

Met Glu Lys Phe Ile Ala Ile Ala Thr Leu Ala Ser Thr Asn Ala Tyr 
1               5                   10                  15      


<210>  26
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA subtype H9 signal peptide

<400>  26

Met Glu Thr Lys Ala Ile Ile Ala Ala Leu Leu Met Val Thr Ala Ala 
1               5                   10                  15      


<210>  27
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA subtype H10 signal peptide

<400>  27

Met Tyr Lys Val Val Val Ile Ile Ala Leu Leu Gly Ala Val Lys Gly 
1               5                   10                  15      


<210>  28
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA subtype H11 signal peptide

<400>  28

Met Glu Lys Thr Leu Leu Phe Ala Ala Ile Phe Leu Cys Val Lys Ala 
1               5                   10                  15      


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA subtype H12 signal peptide

<400>  29

Met Glu Lys Phe Ile Ile Leu Ser Thr Val Leu Ala Ala Ser Phe Ala 
1               5                   10                  15      


Tyr 
    


<210>  30
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA subtype H13 signal peptide

<400>  30

Met Ala Leu Asn Val Ile Ala Thr Leu Thr Leu Ile Ser Val Cys Val 
1               5                   10                  15      


His Ala 
        


<210>  31
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA subtype H14 signal peptide

<400>  31

Met Ile Ala Leu Ile Leu Val Ala Leu Ala Leu Ser His Thr Ala Tyr 
1               5                   10                  15      


Ser 
    


<210>  32
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA subtype H15 signal peptide

<400>  32

Met Asn Thr Gln Ile Ile Val Ile Leu Val Leu Gly Leu Ser Met Val 
1               5                   10                  15      


Lys Ser 
        


<210>  33
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA subtype H16 signal peptide

<400>  33

Met Met Ile Lys Val Leu Tyr Phe Leu Ile Ile Val Leu Gly Arg Tyr 
1               5                   10                  15      


Ser Lys Ala 
            


<210>  34
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H1 stem domain

<400>  34

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Thr Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly Ser 
            20                  25                  30          


Gly Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala Ile Asn Gly Ile 
        35                  40                  45              


Thr Asn Lys Val Asn Thr Val Ile Glu Lys Met Asn Ile Gln Phe Thr 
    50                  55                  60                  


Ala Val Gly Lys Glu Phe Asn Lys Leu Glu Lys Arg Met Glu Asn Leu 
65                  70                  75                  80  


Asn Lys Lys Val Asp Asp Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala 
                85                  90                  95      


Glu Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Phe His Asp 
            100                 105                 110         


Ser Asn Val Lys Asn Leu Tyr Glu Lys Val Lys Ser Gln Leu Lys Asn 
        115                 120                 125             


Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys 
    130                 135                 140                 


Asp Asn Glu Cys Met Glu Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro 
145                 150                 155                 160 


Lys Tyr Ser Glu Glu Ser Lys Leu Asn Arg Glu Lys Val Asp Gly Val 
                165                 170                 175     


Lys Leu Glu Ser 
            180 


<210>  35
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H2 stem domain

<400>  35

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly Tyr His His Ser Asn Asp Gln Gly Ser 
            20                  25                  30          


Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala Ile Asp Gly Ile 
        35                  40                  45              


Thr Asn Arg Val Asn Ser Val Ile Glu Lys Met Asn Thr Gln Phe Glu 
    50                  55                  60                  


Ala Val Gly Lys Glu Phe Ser Asn Leu Glu Lys Arg Leu Glu Asn Leu 
65                  70                  75                  80  


Asn Lys Lys Met Glu Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala 
                85                  90                  95      


Glu Leu Leu Val Leu Met Glu Asn Glu Arg Thr Leu Asp Phe His Asp 
            100                 105                 110         


Ser Asn Val Lys Asn Leu Tyr Asp Arg Val Arg Met Gln Leu Arg Asp 
        115                 120                 125             


Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys 
    130                 135                 140                 


Asp Asp Glu Cys Met Asn Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro 
145                 150                 155                 160 


Lys Tyr Glu Glu Glu Ser Lys Leu Asn Arg Asn Glu Ile Lys Gly Val 
                165                 170                 175     


Lys Leu Ser Asn 
            180 


<210>  36
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H3 stem domain

<400>  36

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Thr 
            20                  25                  30          


Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln Ile 
        35                  40                  45              


Asn Gly Lys Leu Asn Arg Val Ile Glu Lys Thr Asn Glu Lys Phe His 
    50                  55                  60                  


Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu 
65                  70                  75                  80  


Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala 
                85                  90                  95      


Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp 
            100                 105                 110         


Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Arg Arg Gln Leu Arg Glu 
        115                 120                 125             


Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys 
    130                 135                 140                 


Asp Asn Ala Cys Ile Glu Ser Ile Arg Asn Gly Thr Tyr Asp His Asp 
145                 150                 155                 160 


Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly Val 
                165                 170                 175     


Glu Leu Lys 
            


<210>  37
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H4 stem domain

<400>  37

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Gln Gly 
1               5                   10                  15      


Leu Ile Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ala Glu Gly Thr 
            20                  25                  30          


Gly Thr Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln Ile 
        35                  40                  45              


Asn Gly Lys Leu Asn Arg Leu Ile Glu Lys Thr Asn Asp Lys Tyr His 
    50                  55                  60                  


Gln Ile Glu Lys Glu Phe Glu Gln Val Glu Gly Arg Ile Gln Asp Leu 
65                  70                  75                  80  


Glu Asn Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala 
                85                  90                  95      


Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Val Thr Asp 
            100                 105                 110         


Ser Glu Met Asn Lys Leu Phe Glu Arg Val Arg Arg Gln Leu Arg Glu 
        115                 120                 125             


Asn Ala Glu Asp Lys Gly Asn Gly Cys Phe Glu Ile Phe His Lys Cys 
    130                 135                 140                 


Asp Asn Asn Cys Ile Glu Ser Ile Arg Asn Gly Thr Tyr Asp His Asp 
145                 150                 155                 160 


Ile Tyr Arg Asp Glu Ala Ile Asn Asn Arg Phe Gln Ile Gln Gly Val 
                165                 170                 175     


Lys Leu Thr 
            


<210>  38
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H5 stem domain

<400>  38

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly 
1               5                   10                  15      


Met Val Asp Gly Trp Tyr Gly Tyr His His Ser Asn Glu Gln Gly Ser 
            20                  25                  30          


Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala Ile Asp Gly Ile 
        35                  40                  45              


Thr Asn Lys Val Asn Ser Ile Ile Asp Lys Met Asn Thr Arg Phe Glu 
    50                  55                  60                  


Ala Val Gly Lys Glu Phe Asn Asn Leu Glu Arg Arg Val Glu Asn Leu 
65                  70                  75                  80  


Asn Lys Lys Met Glu Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Val 
                85                  90                  95      


Glu Leu Leu Val Leu Met Glu Asn Glu Arg Thr Leu Asp Phe His Asp 
            100                 105                 110         


Ser Asn Val Asn Asn Leu Tyr Asp Lys Val Arg Leu Gln Leu Lys Asp 
        115                 120                 125             


Asn Ala Arg Glu Leu Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys 
    130                 135                 140                 


Asp Asn Glu Cys Met Glu Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro 
145                 150                 155                 160 


Gln Tyr Ser Glu Glu Ala Arg Leu Asn Arg Glu Glu Ile Ser Gly Val 
                165                 170                 175     


Lys Leu Glu Ser 
            180 


<210>  39
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H6 stem domain

<400>  39

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Thr Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly Tyr His His Glu Asn Ser Gln Gly Ser 
            20                  25                  30          


Gly Tyr Ala Ala Asp Arg Glu Ser Thr Gln Lys Ala Val Asp Gly Ile 
        35                  40                  45              


Thr Asn Lys Val Asn Ser Ile Ile Asp Lys Met Asn Thr Gln Phe Glu 
    50                  55                  60                  


Ala Val Asp His Glu Phe Ser Asn Leu Glu Arg Arg Ile Asp Asn Leu 
65                  70                  75                  80  


Asn Lys Arg Met Glu Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala 
                85                  90                  95      


Glu Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Leu His Asp 
            100                 105                 110         


Ala Asn Val Lys Asn Leu Tyr Glu Arg Val Lys Ser Gln Leu Arg Asp 
        115                 120                 125             


Asn Ala Met Ile Leu Gly Asn Gly Cys Phe Glu Phe Trp His Lys Cys 
    130                 135                 140                 


Asp Asp Glu Cys Met Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro 
145                 150                 155                 160 


Lys Tyr Gln Asp Glu Ser Lys Leu Asn Arg Gln Glu Ile Glu Ser Val 
                165                 170                 175     


Lys Leu Glu Ser 
            180 


<210>  40
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H7 stem domain

<400>  40

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Leu Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ala Gln Gly Glu 
            20                  25                  30          


Gly Thr Ala Ala Asp Tyr Lys Ser Thr Gln Ser Ala Ile Asp Gln Ile 
        35                  40                  45              


Thr Gly Lys Leu Asn Arg Leu Ile Glu Lys Thr Asn Gln Gln Phe Glu 
    50                  55                  60                  


Leu Ile Asp Asn Glu Phe Thr Glu Val Glu Lys Gln Ile Gly Asn Leu 
65                  70                  75                  80  


Ile Asn Trp Thr Lys Asp Ser Ile Thr Glu Val Trp Ser Tyr Asn Ala 
                85                  90                  95      


Glu Leu Ile Val Ala Met Glu Asn Gln His Thr Ile Asp Leu Ala Asp 
            100                 105                 110         


Ser Glu Met Asn Arg Leu Tyr Glu Arg Val Arg Lys Gln Leu Arg Glu 
        115                 120                 125             


Asn Ala Glu Glu Asp Gly Thr Gly Cys Phe Glu Ile Phe His Lys Cys 
    130                 135                 140                 


Asp Asp Asp Cys Met Ala Ser Ile Arg Asn Asn Thr Tyr Asp His Ser 
145                 150                 155                 160 


Lys Tyr Arg Glu Glu Ala Met Gln Asn Arg Ile Gln Ile Asp Pro Val 
                165                 170                 175     


Lys Leu Ser 
            


<210>  41
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H8 stem domain

<400>  41

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Ser Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly Phe His His Ser Asn Ser Glu Gly Thr 
            20                  25                  30          


Gly Met Ala Ala Asp Gln Lys Ser Thr Gln Glu Ala Ile Asp Lys Ile 
        35                  40                  45              


Thr Asn Lys Val Asn Asn Ile Val Asp Lys Met Asn Arg Glu Phe Glu 
    50                  55                  60                  


Val Val Asn His Glu Phe Ser Glu Val Glu Lys Arg Ile Asn Met Ile 
65                  70                  75                  80  


Asn Asp Lys Ile Asp Asp Gln Ile Glu Asp Leu Trp Ala Tyr Asn Ala 
                85                  90                  95      


Glu Leu Leu Val Leu Leu Glu Asn Gln Lys Thr Leu Asp Glu His Asp 
            100                 105                 110         


Ser Asn Val Lys Asn Leu Phe Asp Glu Val Lys Arg Arg Leu Ser Ala 
        115                 120                 125             


Asn Ala Ile Asp Ala Gly Asn Gly Cys Phe Asp Ile Leu His Lys Cys 
    130                 135                 140                 


Asp Asn Glu Cys Met Glu Thr Ile Lys Asn Gly Thr Tyr Asp His Lys 
145                 150                 155                 160 


Glu Tyr Glu Glu Glu Ala Lys Leu Glu Arg Ser Lys Ile Asn Gly Val 
                165                 170                 175     


Lys Leu Glu Glu 
            180 


<210>  42
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H9 stem domain

<400>  42

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Pro Gly 
1               5                   10                  15      


Leu Val Ala Gly Trp Tyr Gly Phe Gln His Ser Asn Asp Gln Gly Val 
            20                  25                  30          


Gly Met Ala Ala Asp Lys Gly Ser Thr Gln Lys Ala Ile Asp Lys Ile 
        35                  40                  45              


Thr Ser Lys Val Asn Asn Ile Ile Asp Lys Met Asn Lys Gln Tyr Glu 
    50                  55                  60                  


Val Ile Asp His Glu Phe Asn Glu Leu Glu Ala Arg Leu Asn Met Ile 
65                  70                  75                  80  


Asn Asn Lys Ile Asp Asp Gln Ile Gln Asp Ile Trp Ala Tyr Asn Ala 
                85                  90                  95      


Glu Leu Leu Val Leu Leu Glu Asn Gln Lys Thr Leu Asp Glu His Asp 
            100                 105                 110         


Ala Asn Val Asn Asn Leu Tyr Asn Lys Val Lys Arg Ala Leu Gly Ser 
        115                 120                 125             


Asn Ala Val Glu Asp Gly Asn Gly Cys Phe Glu Leu Tyr His Lys Cys 
    130                 135                 140                 


Asp Asp Gln Cys Met Glu Thr Ile Arg Asn Gly Thr Tyr Asp Arg Gln 
145                 150                 155                 160 


Lys Tyr Gln Glu Glu Ser Arg Leu Glu Arg Gln Lys Ile Glu Gly Val 
                165                 170                 175     


Lys Leu Glu Ser 
            180 


<210>  43
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H10 stem domain

<400>  43

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ala Gln Gly Thr 
            20                  25                  30          


Gly Gln Ala Ala Asp Tyr Lys Ser Thr Gln Ala Ala Ile Asp Gln Ile 
        35                  40                  45              


Thr Gly Lys Leu Asn Arg Leu Ile Glu Lys Thr Asn Thr Glu Phe Glu 
    50                  55                  60                  


Ser Ile Glu Ser Glu Phe Ser Glu Thr Glu His Gln Ile Gly Asn Val 
65                  70                  75                  80  


Ile Asn Trp Thr Lys Asp Ser Ile Thr Asp Ile Trp Thr Tyr Asn Ala 
                85                  90                  95      


Glu Leu Leu Val Ala Met Glu Asn Gln His Thr Ile Asp Met Ala Asp 
            100                 105                 110         


Ser Glu Met Leu Asn Leu Tyr Glu Arg Val Arg Lys Gln Leu Arg Gln 
        115                 120                 125             


Asn Ala Glu Glu Asp Gly Lys Gly Cys Phe Glu Ile Tyr His Thr Cys 
    130                 135                 140                 


Asp Asp Ser Cys Met Glu Ser Ile Arg Asn Asn Thr Tyr Asp His Ser 
145                 150                 155                 160 


Gln Tyr Arg Glu Glu Ala Leu Leu Asn Arg Leu Asn Ile Asn Pro Val 
                165                 170                 175     


Lys Leu Ser 
            


<210>  44
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H11 stem domain

<400>  44

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Pro Gly 
1               5                   10                  15      


Leu Ile Asn Gly Trp Tyr Gly Phe Gln His Arg Asp Glu Glu Gly Thr 
            20                  25                  30          


Gly Ile Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala Ile Asp Gln Ile 
        35                  40                  45              


Thr Ser Lys Val Asn Asn Ile Val Asp Arg Met Asn Thr Asn Phe Glu 
    50                  55                  60                  


Ser Val Gln His Glu Phe Ser Glu Ile Glu Glu Arg Ile Asn Gln Leu 
65                  70                  75                  80  


Ser Lys His Val Asp Asp Ser Val Val Asp Ile Trp Ser Tyr Asn Ala 
                85                  90                  95      


Gln Leu Leu Val Leu Leu Glu Asn Glu Lys Thr Leu Asp Leu His Asp 
            100                 105                 110         


Ser Asn Val Arg Asn Leu His Glu Lys Val Arg Arg Met Leu Lys Asp 
        115                 120                 125             


Asn Ala Lys Asp Glu Gly Asn Gly Cys Phe Thr Phe Tyr His Lys Cys 
    130                 135                 140                 


Asp Asn Lys Cys Ile Glu Arg Val Arg Asn Gly Thr Tyr Asp His Lys 
145                 150                 155                 160 


Glu Phe Glu Glu Glu Ser Lys Ile Asn Arg Gln Glu Ile Glu Gly Val 
                165                 170                 175     


Lys Leu Asp Ser Ser 
            180     


<210>  45
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H12 stem domain

<400>  45

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Pro Gly 
1               5                   10                  15      


Leu Val Ala Gly Trp Tyr Gly Phe Gln His Gln Asn Ala Glu Gly Thr 
            20                  25                  30          


Gly Ile Ala Ala Asp Arg Asp Ser Thr Gln Arg Ala Ile Asp Asn Met 
        35                  40                  45              


Gln Asn Lys Leu Asn Asn Val Ile Asp Lys Met Asn Lys Gln Phe Glu 
    50                  55                  60                  


Val Val Asn His Glu Phe Ser Glu Val Glu Ser Arg Ile Asn Met Ile 
65                  70                  75                  80  


Asn Ser Lys Ile Asp Asp Gln Ile Thr Asp Ile Trp Ala Tyr Asn Ala 
                85                  90                  95      


Glu Leu Leu Val Leu Leu Glu Asn Gln Lys Thr Leu Asp Glu His Asp 
            100                 105                 110         


Ala Asn Val Arg Asn Leu His Asp Arg Val Arg Arg Val Leu Arg Glu 
        115                 120                 125             


Asn Ala Ile Asp Thr Gly Asp Gly Cys Phe Glu Ile Leu His Lys Cys 
    130                 135                 140                 


Asp Asn Asn Cys Met Asp Thr Ile Arg Asn Gly Thr Tyr Asn His Lys 
145                 150                 155                 160 


Glu Tyr Glu Glu Glu Ser Lys Ile Glu Arg Gln Lys Val Asn Gly Val 
                165                 170                 175     


Lys Leu Glu Glu 
            180 


<210>  46
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H13 stem domain

<400>  46

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Pro Gly 
1               5                   10                  15      


Leu Ile Asn Gly Trp Tyr Gly Phe Gln His Gln Asn Glu Gln Gly Thr 
            20                  25                  30          


Gly Ile Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala Ile Asp Gln Ile 
        35                  40                  45              


Thr Thr Lys Ile Asn Asn Ile Ile Asp Lys Met Asn Gly Asn Tyr Asp 
    50                  55                  60                  


Ser Ile Arg Gly Glu Phe Asn Gln Val Glu Lys Arg Ile Asn Met Leu 
65                  70                  75                  80  


Ala Asp Arg Ile Asp Asp Ala Val Thr Asp Ile Trp Ser Tyr Asn Ala 
                85                  90                  95      


Lys Leu Leu Val Leu Leu Glu Asn Asp Lys Thr Leu Asp Met His Asp 
            100                 105                 110         


Ala Asn Val Lys Asn Leu His Glu Gln Val Arg Arg Glu Leu Lys Asp 
        115                 120                 125             


Asn Ala Ile Asp Glu Gly Asn Gly Cys Phe Glu Leu Leu His Lys Cys 
    130                 135                 140                 


Asn Asp Ser Cys Met Glu Thr Ile Arg Asn Gly Thr Tyr Asp His Thr 
145                 150                 155                 160 


Glu Tyr Ala Glu Glu Ser Lys Leu Lys Arg Gln Glu Ile Asp Gly Ile 
                165                 170                 175     


Lys Leu Lys Ser Glu 
            180     


<210>  47
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H14 stem domain

<400>  47

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Gln Gly 
1               5                   10                  15      


Leu Ile Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ala Glu Gly Thr 
            20                  25                  30          


Gly Thr Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln Ile 
        35                  40                  45              


Asn Gly Lys Leu Asn Arg Leu Ile Glu Lys Thr Asn Glu Lys Tyr His 
    50                  55                  60                  


Gln Ile Glu Lys Glu Phe Glu Gln Val Glu Gly Arg Ile Gln Asp Leu 
65                  70                  75                  80  


Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala 
                85                  90                  95      


Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Val Thr Asp 
            100                 105                 110         


Ser Glu Met Asn Lys Leu Phe Glu Arg Val Arg Arg Gln Leu Arg Glu 
        115                 120                 125             


Asn Ala Glu Asp Gln Gly Asn Gly Cys Phe Glu Ile Phe His Gln Cys 
    130                 135                 140                 


Asp Asn Asn Cys Ile Glu Ser Ile Arg Asn Gly Thr Tyr Asp His Asn 
145                 150                 155                 160 


Ile Tyr Arg Asp Glu Ala Ile Asn Asn Arg Ile Lys Ile Asn Pro Val 
                165                 170                 175     


Thr Leu Thr 
            


<210>  48
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H15 stem domain

<400>  48

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Leu Ile Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ala Gln Gly Gln 
            20                  25                  30          


Gly Thr Ala Ala Asp Tyr Lys Ser Thr Gln Ala Ala Ile Asp Gln Ile 
        35                  40                  45              


Thr Gly Lys Leu Asn Arg Leu Ile Glu Lys Thr Asn Lys Gln Phe Glu 
    50                  55                  60                  


Leu Ile Asp Asn Glu Phe Thr Glu Val Glu Gln Gln Ile Gly Asn Val 
65                  70                  75                  80  


Ile Asn Trp Thr Arg Asp Ser Leu Thr Glu Ile Trp Ser Tyr Asn Ala 
                85                  90                  95      


Glu Leu Leu Val Ala Met Glu Asn Gln His Thr Ile Asp Leu Ala Asp 
            100                 105                 110         


Ser Glu Met Asn Lys Leu Tyr Glu Arg Val Arg Arg Gln Leu Arg Glu 
        115                 120                 125             


Asn Ala Glu Glu Asp Gly Thr Gly Cys Phe Glu Ile Phe His Arg Cys 
    130                 135                 140                 


Asp Asp Gln Cys Met Glu Ser Ile Arg Asn Asn Thr Tyr Asn His Thr 
145                 150                 155                 160 


Glu Tyr Arg Gln Glu Ala Leu Gln Asn Arg Ile Met Ile Asn Pro Val 
                165                 170                 175     


Lys Leu Ser 
            


<210>  49
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H16 stem domain

<400>  49

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Pro Gly 
1               5                   10                  15      


Leu Ile Asn Gly Trp Tyr Gly Phe Gln His Gln Asn Glu Gln Gly Thr 
            20                  25                  30          


Gly Ile Ala Ala Asp Lys Ala Ser Thr Gln Lys Ala Ile Asn Glu Ile 
        35                  40                  45              


Thr Thr Lys Ile Asn Asn Ile Ile Glu Lys Met Asn Gly Asn Tyr Asp 
    50                  55                  60                  


Ser Ile Arg Gly Glu Phe Asn Gln Val Glu Lys Arg Ile Asn Met Leu 
65                  70                  75                  80  


Ala Asp Arg Val Asp Asp Ala Val Thr Asp Ile Trp Ser Tyr Asn Ala 
                85                  90                  95      


Lys Leu Leu Val Leu Leu Glu Asn Asp Arg Thr Leu Asp Leu His Asp 
            100                 105                 110         


Ala Asn Val Arg Asn Leu His Asp Gln Val Lys Arg Ala Leu Lys Ser 
        115                 120                 125             


Asn Ala Ile Asp Glu Gly Asp Gly Cys Phe Asn Leu Leu His Lys Cys 
    130                 135                 140                 


Asn Asp Ser Cys Met Glu Thr Ile Arg Asn Gly Thr Tyr Asn His Glu 
145                 150                 155                 160 


Asp Tyr Arg Glu Glu Ser Gln Leu Lys Arg Gln Glu Ile Glu Gly Ile 
                165                 170                 175     


Lys Leu Lys Thr Glu 
            180     


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary cleavage site


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = Gly or Ser

<400>  50

Glu Asn Leu Tyr Phe Gln Xaa 
1               5           


<210>  51
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H1 Luminal domain

<400>  51

Met Gly Ile Tyr Gln 
1               5   


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H2 Luminal domain

<400>  52

Met Gly Val Tyr Gln 
1               5   


<210>  53
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H3 Luminal domain

<400>  53

Ser Gly Tyr Lys Asp 
1               5   


<210>  54
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H4 Luminal domain

<400>  54

Gln Gly Tyr Lys Asp 
1               5   


<210>  55
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H5 Luminal domain

<400>  55

Met Gly Val Tyr Gln 
1               5   


<210>  56
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H6 Luminal domain

<400>  56

Leu Gly Val Tyr Gln 
1               5   


<210>  57
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H7 Luminal domain

<400>  57

Ser Gly Tyr Lys Asp 
1               5   


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H8 Luminal domain

<400>  58

Asn Thr Thr Tyr Lys 
1               5   


<210>  59
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H9 Luminal domain

<400>  59

Glu Gly Thr Tyr Lys 
1               5   


<210>  60
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H10 Luminal domain

<400>  60

Ser Gly Tyr Lys Asp 
1               5   


<210>  61
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H11 Luminal domain

<400>  61

Gly Asn Val Tyr Lys 
1               5   


<210>  62
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H12 Luminal domain

<400>  62

Asn Ser Thr Tyr Lys 
1               5   


<210>  63
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H13 Luminal domain

<400>  63

Asp Asn Val Tyr Lys 
1               5   


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H14 Luminal domain

<400>  64

Met Gly Tyr Lys Asp 
1               5   


<210>  65
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H15 Luminal domain

<400>  65

Ser Gly Tyr Lys Asp 
1               5   


<210>  66
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H16 Luminal domain

<400>  66

Asp Asn Val Tyr Lys 
1               5   


<210>  67
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H1 Transmembrane domain

<400>  67

Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
1               5                   10                  15      


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser 
            20                  25          


<210>  68
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H2 Transmembrane domain

<400>  68

Ile Leu Ala Ile Tyr Ala Thr Val Ala Gly Ser Leu Ser Leu Ala Ile 
1               5                   10                  15      


Met Ile Ala Gly Ile Ser Leu Trp Met Cys Ser 
            20                  25          


<210>  69
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H3 Transmembrane domain

<400>  69

Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys Val 
1               5                   10                  15      


Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln 
            20                  25          


<210>  70
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H4 Transmembrane domain

<400>  70

Ile Ile Leu Trp Ile Ser Phe Ser Ile Ser Cys Phe Leu Leu Val Ala 
1               5                   10                  15      


Leu Leu Leu Ala Phe Ile Leu Trp Ala Cys Gln 
            20                  25          


<210>  71
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H5 Transmembrane domain

<400>  71

Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala Leu Ala Ile 
1               5                   10                  15      


Met Ile Ala Gly Leu Ser Phe Trp Met Cys Ser 
            20                  25          


<210>  72
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H6 Transmembrane

<400>  72

Ile Leu Ala Ile Tyr Ser Thr Val Ser Ser Ser Leu Val Leu Val Gly 
1               5                   10                  15      


Leu Ile Ile Ala Val Gly Leu Trp Met Cys Ser 
            20                  25          


<210>  73
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H7 Transmembrane

<400>  73

Val Ile Leu Trp Phe Ser Phe Gly Ala Ser Cys Phe Leu Leu Leu Ala 
1               5                   10                  15      


Ile Ala Met Gly Leu Val Phe Ile Cys Val Lys 
            20                  25          


<210>  74
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H8 Transmembrane

<400>  74

Ile Leu Ser Ile Tyr Ser Thr Val Ala Ala Ser Leu Cys Leu Ala Ile 
1               5                   10                  15      


Leu Ile Ala Gly Gly Leu Ile Leu Gly Met Gln 
            20                  25          


<210>  75
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H9 Transmembrane

<400>  75

Ile Leu Thr Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Ala Met 
1               5                   10                  15      


Gly Phe Ala Ala Phe Leu Phe Trp Ala Met Ser 
            20                  25          


<210>  76
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H10 Transmembrane

<400>  76

Ile Ile Leu Trp Phe Ser Phe Gly Glu Ser Cys Phe Val Leu Leu Ala 
1               5                   10                  15      


Val Val Met Gly Leu Val Phe Phe Cys Leu Lys 
            20                  25          


<210>  77
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H11 Transmembrane

<400>  77

Ile Leu Ser Ile Tyr Ser Cys Ile Ala Ser Ser Leu Val Leu Ala Ala 
1               5                   10                  15      


Leu Ile Met Gly Phe Met Phe Trp Ala Cys Ser 
            20                  25          


<210>  78
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H12 Transmembrane

<400>  78

Ile Leu Ser Ile Tyr Ser Ser Val Ala Ser Ser Leu Val Leu Leu Leu 
1               5                   10                  15      


Met Ile Ile Gly Gly Phe Ile Phe Gly Cys Gln Asn 
            20                  25              


<210>  79
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H13 Transmembrane

<400>  79

Ala Leu Ser Ile Tyr Ser Cys Ile Ala Ser Ser Val Val Leu Val Gly 
1               5                   10                  15      


Leu Ile Leu Ser Phe Ile Met Trp Ala Cys Ser Ser 
            20                  25              


<210>  80
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H14 Transmembrane

<400>  80

Ile Ile Leu Trp Ile Ser Phe Ser Met Ser Cys Phe Val Phe Val Ala 
1               5                   10                  15      


Leu Ile Leu Gly Phe Val Leu Trp Ala Cys Gln 
            20                  25          


<210>  81
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H15 Transmembrane

<400>  81

Val Ile Leu Trp Phe Ser Phe Gly Ala Ser Cys Val Met Leu Leu Ala 
1               5                   10                  15      


Ile Ala Met Gly Leu Ile Phe Met Cys Val Lys Asn 
            20                  25              


<210>  82
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H16 Transmembrane

<400>  82

Val Leu Ser Ile Tyr Ser Cys Ile Ala Ser Ser Ile Val Leu Val Gly 
1               5                   10                  15      


Leu Ile Leu Ala Phe Ile Met Trp Ala Cys Ser 
            20                  25          


<210>  83
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H1 Cytoplasmic domain

<400>  83

Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
1               5                   10  


<210>  84
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H2 Cytoplasmic domain

<400>  84

Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
1               5                   10  


<210>  85
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H3 Cytoplasmic domain

<400>  85

Arg Gly Asn Ile Arg Cys Asn Ile Cys Ile 
1               5                   10  


<210>  86
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H4 Cytoplasmic domain

<400>  86

Asn Gly Asn Ile Arg Cys Gln Ile Cys Ile 
1               5                   10  


<210>  87
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H5 Cytoplasmic domain

<400>  87

Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
1               5                   10  


<210>  88
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H6 Cytoplasmic domain

<400>  88

Asn Gly Ser Met Gln Cys Arg Ile Cys Ile 
1               5                   10  


<210>  89
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H7 Cytoplasmic domain

<400>  89

Asn Gly Asn Met Arg Cys Thr Ile Cys Ile 
1               5                   10  


<210>  90
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H8 Cytoplasmic domain

<400>  90

Asn Gly Ser Cys Arg Cys Met Phe Cys Ile 
1               5                   10  


<210>  91
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H9 Cytoplasmic domain

<400>  91

Asn Gly Ser Cys Arg Cys Asn Ile Cys Ile 
1               5                   10  


<210>  92
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H10 Cytoplasmic domain

<400>  92

Asn Gly Asn Met Arg Cys Thr Ile Cys Ile 
1               5                   10  


<210>  93
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H11 Cytoplasmic domain

<400>  93

Asn Gly Ser Cys Arg Cys Thr Ile Cys Ile 
1               5                   10  


<210>  94
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H12 Cytoplasmic domain

<400>  94

Gly Asn Val Arg Cys Thr Phe Cys Ile 
1               5                   


<210>  95
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H13 Cytoplasmic domain

<400>  95

Gly Asn Cys Arg Phe Asn Val Cys Ile 
1               5                   


<210>  96
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H14 Cytoplasmic domain

<400>  96

Asn Gly Asn Ile Arg Cys Gln Ile Cys Ile 
1               5                   10  


<210>  97
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H15 Cytoplasmic domain

<400>  97

Gly Asn Leu Arg Cys Thr Ile Cys Ile 
1               5                   


<210>  98
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary influenza A HA2 domain subtype H16 Cytoplasmic domain

<400>  98

Asn Gly Ser Cys Arg Phe Asn Val Cys Ile 
1               5                   10  


<210>  99
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conserved NA epitope

<400>  99

Ile Leu Arg Thr Gln Glu Ser Glu Cys 
1               5                   


<210>  100
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NP epitope from PR8

<400>  100

Ala Ser Asn Glu Asn Met Glu Thr Met 
1               5                   


<210>  101
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6x Histag

<400>  101

His His His His His His 
1               5       


<210>  102
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary foldon domain sequence

<400>  102

Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val 
1               5                   10                  15      


Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25                  


<210>  103
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary thrombin cleavage site

<400>  103

Leu Val Pro Arg Gly Ser Pro 
1               5           


<210>  104
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Irrelevant peptide

<400>  104

Arg Ala His Tyr Asn Ile Val Thr Phe 
1               5                   


<210>  105
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NP epitope from Leningrad ts

<400>  105

Ala Ser Asn Glu Asn Met Asp Thr Met 
1               5                   


<210>  106
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NP epitope from H1N1pdm09 (A/NL/602)

<400>  106

Ala Ser Asn Glu Asn Val Glu Ile Met 
1               5                   


<210>  107
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mH11/B chimeric HA for rescue in B/Yamagata/16/88

<400>  107

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Met Gly Leu Ile Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Lys Ile Glu Leu Ser Thr Ser Asn Val Ile Asn Ala Glu Val 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Glu Ser Cys Pro Phe 
145                 150                 155                 160 


Gly Ser Ser Asn Ser Phe Phe Ala Thr Met Ala Trp Ala Val Pro His 
                165                 170                 175     


Gln Ser Gly Thr Tyr Thr Asn Pro Leu Thr Val Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Thr Thr Leu Lys Met His Gln Leu Tyr Gly Asp Ser Asn Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Asp Phe Pro Asn Gln Thr Glu Asp Glu Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn His 
    530                 535                 540                 


Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val Thr 
545                 550                 555                 560 


Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp Asn Val 
                565                 570                 575     


Ser Cys Ser Ile Cys Leu 
            580         


<210>  108
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Yamagata/16/88 120 loop

<400>  108

Asn Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Arg Ala Pro 
1               5                   10                  15      


Gly Gly Pro Tyr Arg Leu 
            20          


<210>  109
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 120 loop substituted with amino acids 
       from A/Vietnam/1203/04

<400>  109

Lys Ile Gln Leu Ser Thr Lys Asn Val Ile Asn Ala Glu His Ala Pro 
1               5                   10                  15      


Gly Gly Pro Tyr Arg Leu 
            20          


<210>  110
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Yamagata/16/88 150 loop

<400>  110

Asn Val Thr Ser Arg Asn Gly 
1               5           


<210>  111
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 150 loop substituted with amino acids 
       from A/Vietnam/1203/04

<400>  111

Tyr Gln Gly Lys Ser Ser 
1               5       


<210>  112
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Yamagata/16/88 160 loop

<400>  112

Arg Asp Asn Lys Thr Ala 
1               5       


<210>  113
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 160 loop substituted with amino acids 
       from A/Vietnam/1203/04

<400>  113

Lys Lys Asn Ser Thr Tyr 
1               5       


<210>  114
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Yamagata/16/88 190 helix

<400>  114

Asn Lys Asn Gln Met Lys Asn 
1               5           


<210>  115
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 190 helix substituted with amino acids
       from A/Vietnam/1203/04

<400>  115

Asn Asp Ala Ala Met Gln Thr 
1               5           


<210>  116
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Hong Kong/8/73 HA signal peptide

<400>  116

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala 
1               5                   10                  15  


<210>  117
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Hong Kong/8/73 HA HA1 polypeptide  (no signal peptide)

<400>  117

Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Gln 
        35                  40                  45              


Thr Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp 
    50                  55                  60                  


Val Ala Leu Gly Arg Pro Lys Cys Met Gly Thr Ile Pro Ser Ala Lys 
65                  70                  75                  80  


Ala Ser Ile Leu His Glu Val Lys Pro Val Thr Ser Gly Cys Phe Pro 
                85                  90                  95      


Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg 
            100                 105                 110         


Gly Tyr Glu Asn Ile Arg Leu Ser Ala Arg Asn Val Thr Asn Ala Glu 
        115                 120                 125             


Thr Ala Pro Gly Gly Pro Tyr Ile Val Gly Thr Ser Gly Ser Cys Pro 
    130                 135                 140                 


Asn Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val 
145                 150                 155                 160 


Pro Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Val Glu Val Pro Tyr 
                165                 170                 175     


Ile Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser 
            180                 185                 190         


Asp Asp Glu Thr Gln Met Val Lys Leu Tyr Gly Asp Ser Lys Pro Gln 
        195                 200                 205             


Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln 
    210                 215                 220                 


Ile Gly Gly Phe Pro Asn Gln Ala Glu Asp Glu Gly Leu Pro Gln Ser 
225                 230                 235                 240 


Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr Gly 
                245                 250                 255     


Thr Ile Ala Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp Cys 
            260                 265                 270         


Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly 
        275                 280                 285             


Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys 
    290                 295                 300                 


Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile 
305                 310                 315                 320 


Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro 
                325                 330                 335     


Pro Ala Lys Leu Leu Lys Glu Arg 
            340                 


<210>  118
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Hong Kong/8/73 HA HA2 polypeptide  (no stop codon)

<400>  118

Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly Ala His Gly Val 
            20                  25                  30          


Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile 
        35                  40                  45              


Thr Lys Asn Leu Asn Ser Leu Ser Glu Leu Glu Val Lys Asn Leu Gln 
    50                  55                  60                  


Arg Leu Ser Gly Ala Met Asp Glu Leu His Asn Glu Ile Leu Glu Leu 
65                  70                  75                  80  


Asp Glu Lys Val Asp Asp Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile 
                85                  90                  95      


Glu Leu Ala Val Leu Leu Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp 
            100                 105                 110         


Glu His Leu Leu Ala Leu Glu Arg Lys Leu Lys Lys Met Leu Gly Pro 
        115                 120                 125             


Ser Ala Val Asp Ile Gly Asn Gly Cys Phe Glu Thr Lys His Lys Cys 
    130                 135                 140                 


Asn Gln Thr Cys Leu Asp Arg Ile Ala Ala Gly Thr Phe Asn Ala Gly 
145                 150                 155                 160 


Glu Phe Ser Leu Pro Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser 
                165                 170                 175     


Leu Asn Asp Asp Gly Leu Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser 
            180                 185                 190         


Thr Ala Ala Ser Ser Leu Ala Val Thr Leu Met Ile Ala Ile Phe Ile 
        195                 200                 205             


Val Tyr Met Val Ser Arg Asp Asn Val Ser Cys Ser Ile Cys Leu 
    210                 215                 220             


<210>  119
<211>  530
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Hong Kong/8/73 HA Ectodomain  (excludes signal peptide, 
       transmembrane domain, cytoplasmic tail domain)

<400>  119

Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Gln 
        35                  40                  45              


Thr Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp 
    50                  55                  60                  


Val Ala Leu Gly Arg Pro Lys Cys Met Gly Thr Ile Pro Ser Ala Lys 
65                  70                  75                  80  


Ala Ser Ile Leu His Glu Val Lys Pro Val Thr Ser Gly Cys Phe Pro 
                85                  90                  95      


Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg 
            100                 105                 110         


Gly Tyr Glu Asn Ile Arg Leu Ser Ala Arg Asn Val Thr Asn Ala Glu 
        115                 120                 125             


Thr Ala Pro Gly Gly Pro Tyr Ile Val Gly Thr Ser Gly Ser Cys Pro 
    130                 135                 140                 


Asn Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val 
145                 150                 155                 160 


Pro Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Val Glu Val Pro Tyr 
                165                 170                 175     


Ile Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser 
            180                 185                 190         


Asp Asp Glu Thr Gln Met Val Lys Leu Tyr Gly Asp Ser Lys Pro Gln 
        195                 200                 205             


Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln 
    210                 215                 220                 


Ile Gly Gly Phe Pro Asn Gln Ala Glu Asp Glu Gly Leu Pro Gln Ser 
225                 230                 235                 240 


Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr Gly 
                245                 250                 255     


Thr Ile Ala Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp Cys 
            260                 265                 270         


Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly 
        275                 280                 285             


Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys 
    290                 295                 300                 


Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile 
305                 310                 315                 320 


Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro 
                325                 330                 335     


Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr 
        355                 360                 365             


Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser 
385                 390                 395                 400 


Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu 
                405                 410                 415     


Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg 
            420                 425                 430         


Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn 
        435                 440                 445             


Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg 
    450                 455                 460                 


Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile 
                485                 490                 495     


Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp 
            500                 505                 510         


Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn 
        515                 520                 525             


His Thr 
    530 


<210>  120
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Hong Kong/8/73 HA Transmembrane domain

<400>  120

Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val Thr Leu 
1               5                   10                  15      


Met Ile Ala Ile Phe Ile Val 
            20              


<210>  121
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Hong Kong/8/73 HA Cytoplasmic domain (no stop codon)

<400>  121

Tyr Met Val Ser Arg Asp Asn Val Ser Cys Ser Ile Cys Leu 
1               5                   10                  


<210>  122
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Hong Kong/8/73 HA Stem domain (encompasses alanines at 
       interface; no signal peptide or stop codon) Piece 1:

<400>  122

Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser His Phe Ala 
        35                  40          


<210>  123
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Hong Kong/8/73 HA Stem domain (encompa-sses alanines at 
       interface; no signal peptide or stop codon) Piece 2

<400>  123

Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
1               5                   10                  15      


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
            20                  25                  30          


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
        35                  40                  45              


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
    50                  55                  60                  


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
65                  70                  75                  80  


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
                85                  90                  95      


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
            100                 105                 110         


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
        115                 120                 125             


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
    130                 135                 140                 


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
145                 150                 155                 160 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
                165                 170                 175     


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn Gly Cys 
            180                 185                 190         


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
        195                 200                 205             


Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
    210                 215                 220                 


Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn His 
225                 230                 235                 240 


Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val Thr 
                245                 250                 255     


Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp Asn Val 
            260                 265                 270         


Ser Cys Ser Ile Cys Leu 
        275             


<210>  124
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Hong Kong/8/73 HA Globular head domain (not including alanines)

<400>  124

Asn Leu Lys Gly Thr Gln Thr Arg Gly Lys Leu Cys Pro Asn Cys Leu 
1               5                   10                  15      


Asn Cys Thr Asp Leu Asp Val Ala Leu Gly Arg Pro Lys Cys Met Gly 
            20                  25                  30          


Thr Ile Pro Ser Ala Lys Ala Ser Ile Leu His Glu Val Lys Pro Val 
        35                  40                  45              


Thr Ser Gly Cys Phe Pro Ile Met His Asp Arg Thr Lys Ile Arg Gln 
    50                  55                  60                  


Leu Pro Asn Leu Leu Arg Gly Tyr Glu Asn Ile Arg Leu Ser Ala Arg 
65                  70                  75                  80  


Asn Val Thr Asn Ala Glu Thr Ala Pro Gly Gly Pro Tyr Ile Val Gly 
                85                  90                  95      


Thr Ser Gly Ser Cys Pro Asn Val Thr Asn Gly Asn Gly Phe Phe Ala 
            100                 105                 110         


Thr Met Ala Trp Ala Val Pro Lys Asn Lys Thr Ala Thr Asn Pro Leu 
        115                 120                 125             


Thr Val Glu Val Pro Tyr Ile Cys Thr Lys Gly Glu Asp Gln Ile Thr 
    130                 135                 140                 


Val Trp Gly Phe His Ser Asp Asp Glu Thr Gln Met Val Lys Leu Tyr 
145                 150                 155                 160 


Gly Asp Ser Lys Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr 
                165                 170                 175     


Thr His Tyr Val Ser Gln Ile Gly Gly Phe Pro Asn Gln Ala Glu Asp 
            180                 185                 190         


Glu Gly Leu Pro Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln 
        195                 200                 205             


Lys Pro Gly Lys Thr Gly Thr Ile Ala Tyr Gln Arg Gly Val Leu Leu 
    210                 215                 220                 


Pro Gln Lys Val Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly 
225                 230                 235                 240 


Ser Leu Pro Leu Ile Gly Glu 
                245         


<210>  125
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 120 loop substituted with amino acids 
       from A/Mallard/Sweden/24/2002 virus (H8)

<400>  125

Arg Ile Arg Leu Ser Thr Tyr Asn Val Ile Asn Ala Glu Thr Ala Pro 
1               5                   10                  15      


Gly Gly Pro Tyr Arg Leu 
            20          


<210>  126
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 150 loop substituted with amino acids 
       from A/Mallard/Sweden/24/2002 virus (H8)

<400>  126

Asn Ala Ser Thr Gly Gly Gln Ser 
1               5               


<210>  127
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 160 loop substituted with amino acids 
       from A/Mallard/Sweden/24/2002 virus (H8)

<400>  127

Lys Lys Lys Ala Asp Thr Tyr 
1               5           


<210>  128
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TBAExemplary B/Yamagata/16/88 190 helix substituted with amino 
       acids from A/Mallard/Sweden/24/2002 virus (H8)

<400>  128

Ala Asp Ala Lys Met Gln Thr 
1               5           


<210>  129
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 120 loop substituted with amino acids 
       from A/northern shoveler/Netherlands/18/99

<400>  129

Lys Ile Glu Leu Ser Thr Ser Asn Val Ile Asn Ala Glu Val Ala Pro 
1               5                   10                  15      


Gly Gly Pro Tyr Arg Leu 
            20          


<210>  130
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 150 loop substituted with amino acids 
       from A/northern shoveler/Netherlands/18/99

<400>  130

Pro Phe Gly Ser Ser Asn Ser 
1               5           


<210>  131
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 160 loop substituted with amino acids 
       from A/northern shoveler/Netherlands/18/99

<400>  131

His Gln Ser Gly Thr Tyr 
1               5       


<210>  132
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 190 helix substituted with amino acids
       from A/northern shoveler/Netherlands/18/99

<400>  132

Thr Thr Leu Lys Met His Gln 
1               5           


<210>  133
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 150 loop substituted with amino acids 
       from A/black headed gull/Sweden/1/99

<400>  133

Pro Asp Lys Gly Ala Ser Ser 
1               5           


<210>  134
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 160 loop substituted with amino acids 
       from A/black headed gull/Sweden/1/99

<400>  134

Lys Arg Gly Asn Gln Tyr 
1               5       


<210>  135
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 190 helix substituted with amino acids
       from A/black headed gull/Sweden/1/99

<400>  135

Val Ser Thr Asn Met Ala Lys 
1               5           


<210>  136
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 120 loop substituted with amino acids 
       from A/mallard/interior Alaska/7MP0167/2007

<400>  136

Arg Ile Lys Leu Ser Thr Phe Asn Val Ile Asn Ala Glu Thr Ala Pro 
1               5                   10                  15      


Gly Gly Pro Tyr Arg Leu 
            20          


<210>  137
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 150 loop substituted with amino acids 
       from A/mallard/interior Alaska/7MP0167/2007

<400>  137

Asn Asn Thr Ser Asn Gln Gly Ser 
1               5               


<210>  138
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 160 loop substituted with amino acids 
       from A/mallard/interior Alaska/7MP0167/2007

<400>  138

Leu Lys Ser Gly Gln Phe 
1               5       


<210>  139
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 190 helix substituted with amino acids
       from A/mallard/interior Alaska/7MP0167/2007

<400>  139

Pro Thr Ser Asp Met Gln Ile 
1               5           


<210>  140
<211>  1870
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding mH13/B chimeric HA for rescue in 
       B/Yamagata/16/88

<400>  140
agcagaagca gagcattttc taatatccac aaaatgaagg caataattgt actactcatg       60

gtagtaacat ccaacgcaga tcgaatctgc actgggataa catcttcaaa ctcacctcat      120

gtggtcaaaa cagctactca aggggaagtt aatgtgactg gtgtgatacc actgacaaca      180

acaccaacaa aatctcattt tgcaaatctc aaaggaacaa agaccagagg gaaactatgc      240

ccaaactgtc tcaactgcac agatctggat gtggccttgg gcagaccaat gtgtatgggg      300

aacatacctt cggcaaaagc ttcaatactc cacgaagtca gacctgttac atccgggtgc      360

tttcctataa tgcacgacag aacaaaaatc agacagctac ccaatcttct cagaggatat      420

gaaagaatcg agttatcaac ccataacgtt atcaacgcag aagtggcacc aggaggaccc      480

tacagacttg gaacctcaaa atcttgccca gataaaggag ccagcagctt cttcgcaaca      540

atggcttggg ctgtcccaaa gagaggaaat cagtatacga atccactaac agtagaagta      600

ccatacattt gcacaaaagg agaagaccaa attactgttt gggggttcca ttctgatgtt      660

tccacaaaca tggcgaaact ctatggagac tcaaatcctc aaaagttcac ctcatctgcc      720

aatggagtaa ccacacatta tgtttctcag attggtgact tcccaaatca aacagaagac      780

ggagggctac cacaaagcgg cagaattgtt gttgattaca tggtgcaaaa acctgggaaa      840

acaggaacaa ttgtctatca aagaggtgtt ttgttgcctc aaaaggtgtg gtgcgcaagt      900

ggcaggagca aggtaataaa agggtccttg cctttaattg gtgaagcaga ttgccttcac      960

gaaaaatacg gtggattaaa caaaagcaag ccttactaca caggagaaca tgcaaaagcc     1020

ataggaaatt gcccaatatg ggtgaaaaca cctttgaagc ttgccaatgg aaccaaatat     1080

agacctcctg caaaactatt aaaggaaagg ggtttcttcg gagctattgc tggtttctta     1140

gagggaggat gggaaggaat gattgcaggt tggcacggat acacatctca tggagcacat     1200

ggagtggcag tggcagcaga ccttaagagc acgcaagaag ccataaacaa gataacaaaa     1260

aatctcaatt ctttgagtga gctagaagta aagaatcttc aaagactaag tggtgccatg     1320

gatgaactcc acaacgaaat actcgagctg gatgagaaag tggatgatct cagagctgac     1380

acaataagct cgcaaataga gcttgcagtc ttgctttcca acgaaggaat aataaacagt     1440

gaagatgagc atctattggc acttgagaga aaactaaaga aaatgctggg tccctctgct     1500

gtagacatag ggaatggatg cttcgaaacc aaacacaagt gcaaccagac ctgcttagac     1560

aggatagctg ctggcacctt taatgcagga gaattttctc ttcccacttt tgattcactg     1620

aatattactg ctgcatcttt aaatgatgat ggattggata atcatactat actgctctac     1680

tactcaactg ctgcttctag tttggccgta acattgatga tagctatttt tattgtttat     1740

atggtctcca gagacaatgt ttcttgctcc atctgtctat aaggaaaatt aagccctgta     1800

ttttccttta ttgtagtgct tgtttgcttg ttaccattac aaagaaacgt tattgaaaaa     1860

tgctcttgtt                                                            1870


<210>  141
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of mH13/B chimeric HA for rescue in 
       B/Yamagata/16/88

<400>  141

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Met Gly Asn Ile Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Arg Ile Glu Leu Ser Thr His Asn Val Ile Asn Ala Glu Val 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Lys Ser Cys Pro Asp 
145                 150                 155                 160 


Lys Gly Ala Ser Ser Phe Phe Ala Thr Met Ala Trp Ala Val Pro Lys 
                165                 170                 175     


Arg Gly Asn Gln Tyr Thr Asn Pro Leu Thr Val Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Val Ser Thr Asn Met Ala Lys Leu Tyr Gly Asp Ser Asn Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Asp Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn His 
    530                 535                 540                 


Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val Thr 
545                 550                 555                 560 


Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp Asn Val 
                565                 570                 575     


Ser Cys Ser Ile Cys Leu 
            580         


<210>  142
<211>  1715
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding influenza A/black headed 
       gull/Sweden/1/99 virus HA

<400>  142
cccagtagtc gcattcttga tattaaccag tacatgcgta caggctgata ggatatgtgt       60

tgggtactta agcaccaact catcagaaaa ggttgacaca ctgttagaaa acgatgttcc      120

ggttacaagc tctgttgatc tggttgagac taaccacaca ggaacatatt gttctttggg      180

tggaatcagt ccggtgcacc tgggagactg tagcttcgag ggctggattg tagggaaccc      240

tgcctgtgcc agcaacctgg ggatcagaga atggtcatac ttgattgaag atccttctgc      300

tcctcatgga ttgtgctacc caggggagtt agacaacaat ggagaattga ggcacttgtt      360

cagtggaatc agatctttca gtagaacaga gttgattgca cctacttctt ggggggcagt      420

gaatgatgga gtatcgtcgg cctgtccaga taaaggagcc agcagctttt accggaactt      480

ggtatggttt gtgaagagag gaaatcagta tcctgtaatc cgcgggacct acaacaacac      540

tactggcaga gatgttttgg ttatatgggg tatacatcac cctgtttcca cagacgaagc      600

gaaacaacta tatgtcaata acaacccata cacgttggta tctaccagtt catggagtag      660

gaaatacaac ttagagactg gaacccggcc tggatacaat ggccaaaaga gttggatgaa      720

gatttactgg tatttgatgc acccagggga gtcaatcagt ttcgaaagca atggaggatt      780

attggcaccc agatatggtt atattattga ggaatatgga aaagggcgaa ttttccaaag      840

ccgcattcga attgctaaat gcaatactaa gtgccaaaca tctgtcggtg ggataaatac      900

caacaaaaca tttcaaaaca tagagagaaa tgcacttggg gattgcccga aatacataaa      960

atctggacag ctcaagttag ccaccggact taggaatgta cctgccatat caaacagagg     1020

gttgttcggg gctattgcag gcttcataga aggtggttgg ccaggattaa taaatggttg     1080

gtatggattc caacatcaga acgaacaagg agtgggcatg gctgcagaca aagagtcaac     1140

acaaaaggct attgatcaaa taacaaccaa gataaacaat atcattgaaa aaatgaatgg     1200

gaattatgac tccatacgag gtgaattcaa tcaggtggaa caaagaataa atatgcttgc     1260

agacagaata gatgatgctg taactgatgt atggtcatac aatgcaaagc ttcttgtgtt     1320

actagagaac gataaaactc tagacatgca tgatgctaat gttagaaacc tgcatgatca     1380

agtccgtaga gcactaaaga ccaatgcaat tgatgaggga aatggatgtt tcgaactcct     1440

ccataaatgc aatgactctt gcatggagac aataagaaat ggaacgtaca atcatacaga     1500

atatgaggaa gaatccaaat taaagagaca ggaaatagaa ggaataaagc tgaagtcaga     1560

cgatagtgtt tataaagcac tatcgattta cagctgcatt gcaagcagta ttgtattggt     1620

aggactcata cttacattca tcatgtgggc atgcagcagt ggcaattgcc ggttcaatat     1680

ttgtatataa gtagaaaaaa cacccttgtt ctact                                1715


<210>  143
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of influenza A/black headed gull/Sweden/1/99 
       virus HA

<400>  143

Met Asp Ile Pro Val Val Ala Phe Leu Ile Leu Thr Ser Thr Cys Val 
1               5                   10                  15      


Gln Ala Asp Arg Ile Cys Val Gly Tyr Leu Ser Thr Asn Ser Ser Glu 
            20                  25                  30          


Lys Val Asp Thr Leu Leu Glu Asn Asp Val Pro Val Thr Ser Ser Val 
        35                  40                  45              


Asp Leu Val Glu Thr Asn His Thr Gly Thr Tyr Cys Ser Leu Gly Gly 
    50                  55                  60                  


Ile Ser Pro Val His Leu Gly Asp Cys Ser Phe Glu Gly Trp Ile Val 
65                  70                  75                  80  


Gly Asn Pro Ala Cys Ala Ser Asn Leu Gly Ile Arg Glu Trp Ser Tyr 
                85                  90                  95      


Leu Ile Glu Asp Pro Ser Ala Pro His Gly Leu Cys Tyr Pro Gly Glu 
            100                 105                 110         


Leu Asp Asn Asn Gly Glu Leu Arg His Leu Phe Ser Gly Ile Arg Ser 
        115                 120                 125             


Phe Ser Arg Thr Glu Leu Ile Ala Pro Thr Ser Trp Gly Ala Val Asn 
    130                 135                 140                 


Asp Gly Val Ser Ser Ala Cys Pro Asp Lys Gly Ala Ser Ser Phe Tyr 
145                 150                 155                 160 


Arg Asn Leu Val Trp Phe Val Lys Arg Gly Asn Gln Tyr Pro Val Ile 
                165                 170                 175     


Arg Gly Thr Tyr Asn Asn Thr Thr Gly Arg Asp Val Leu Val Ile Trp 
            180                 185                 190         


Gly Ile His His Pro Val Ser Thr Asp Glu Ala Lys Gln Leu Tyr Val 
        195                 200                 205             


Asn Asn Asn Pro Tyr Thr Leu Val Ser Thr Ser Ser Trp Ser Arg Lys 
    210                 215                 220                 


Tyr Asn Leu Glu Thr Gly Thr Arg Pro Gly Tyr Asn Gly Gln Lys Ser 
225                 230                 235                 240 


Trp Met Lys Ile Tyr Trp Tyr Leu Met His Pro Gly Glu Ser Ile Ser 
                245                 250                 255     


Phe Glu Ser Asn Gly Gly Leu Leu Ala Pro Arg Tyr Gly Tyr Ile Ile 
            260                 265                 270         


Glu Glu Tyr Gly Lys Gly Arg Ile Phe Gln Ser Arg Ile Arg Ile Ala 
        275                 280                 285             


Lys Cys Asn Thr Lys Cys Gln Thr Ser Val Gly Gly Ile Asn Thr Asn 
    290                 295                 300                 


Lys Thr Phe Gln Asn Ile Glu Arg Asn Ala Leu Gly Asp Cys Pro Lys 
305                 310                 315                 320 


Tyr Ile Lys Ser Gly Gln Leu Lys Leu Ala Thr Gly Leu Arg Asn Val 
                325                 330                 335     


Pro Ala Ile Ser Asn Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
            340                 345                 350         


Glu Gly Gly Trp Pro Gly Leu Ile Asn Gly Trp Tyr Gly Phe Gln His 
        355                 360                 365             


Gln Asn Glu Gln Gly Val Gly Met Ala Ala Asp Lys Glu Ser Thr Gln 
    370                 375                 380                 


Lys Ala Ile Asp Gln Ile Thr Thr Lys Ile Asn Asn Ile Ile Glu Lys 
385                 390                 395                 400 


Met Asn Gly Asn Tyr Asp Ser Ile Arg Gly Glu Phe Asn Gln Val Glu 
                405                 410                 415     


Gln Arg Ile Asn Met Leu Ala Asp Arg Ile Asp Asp Ala Val Thr Asp 
            420                 425                 430         


Val Trp Ser Tyr Asn Ala Lys Leu Leu Val Leu Leu Glu Asn Asp Lys 
        435                 440                 445             


Thr Leu Asp Met His Asp Ala Asn Val Arg Asn Leu His Asp Gln Val 
    450                 455                 460                 


Arg Arg Ala Leu Lys Thr Asn Ala Ile Asp Glu Gly Asn Gly Cys Phe 
465                 470                 475                 480 


Glu Leu Leu His Lys Cys Asn Asp Ser Cys Met Glu Thr Ile Arg Asn 
                485                 490                 495     


Gly Thr Tyr Asn His Thr Glu Tyr Glu Glu Glu Ser Lys Leu Lys Arg 
            500                 505                 510         


Gln Glu Ile Glu Gly Ile Lys Leu Lys Ser Asp Asp Ser Val Tyr Lys 
        515                 520                 525             


Ala Leu Ser Ile Tyr Ser Cys Ile Ala Ser Ser Ile Val Leu Val Gly 
    530                 535                 540                 


Leu Ile Leu Thr Phe Ile Met Trp Ala Cys Ser Ser Gly Asn Cys Arg 
545                 550                 555                 560 


Phe Asn Ile Cys Ile 
                565 


<210>  144
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mouse adapted influenza B/Malaysia/2506/20/03 HA


<220>
<221>  misc_feature
<222>  (212)..(212)
<223>  Xaa = Asn or Ser

<220>
<221>  misc_feature
<222>  (214)..(214)
<223>  Xaa = Asn, Ile, Thr or Ser

<400>  144

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Asn Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asn 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Lys Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Asp Asn Asn Lys Thr Ala Thr Asn Ser Leu Thr Ile Glu Val 
            180                 185                 190         


Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe 
        195                 200                 205             


His Ser Asp Xaa Glu Xaa Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys 
    210                 215                 220                 


Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val 
225                 230                 235                 240 


Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro 
                245                 250                 255     


Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys 
            260                 265                 270         


Thr Gly Thr Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val 
        275                 280                 285             


Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu 
    290                 295                 300                 


Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys 
305                 310                 315                 320 


Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys 
                325                 330                 335     


Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr 
            340                 345                 350         


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
        355                 360                 365             


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
    370                 375                 380                 


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
385                 390                 395                 400 


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser 
                405                 410                 415     


Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met 
            420                 425                 430         


Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp 
        435                 440                 445             


Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
    450                 455                 460                 


Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
465                 470                 475                 480 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                485                 490                 495     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            500                 505                 510         


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
        515                 520                 525             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
    530                 535                 540                 


Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu 
545                 550                 555                 560 


Ala Val Thr Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg 
                565                 570                 575     


Asp Asn Val Ser Cys Ser Ile Cys Leu 
            580                 585 


<210>  145
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Malaysia/2506/20/03 HA Signal Peptide

<400>  145

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala 
1               5                   10                  15  


<210>  146
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Malaysia/2506/20/03 HA HA1 Domain


<220>
<221>  misc_feature
<222>  (197)..(197)
<223>  Xaa = Asn or Ser

<220>
<221>  misc_feature
<222>  (199)..(199)
<223>  Xaa = Asn, Ile, Thr or Ser

<400>  146

Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu 
        35                  40                  45              


Thr Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp 
    50                  55                  60                  


Val Ala Leu Gly Arg Pro Lys Cys Thr Gly Asn Ile Pro Ser Ala Arg 
65                  70                  75                  80  


Val Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro 
                85                  90                  95      


Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg 
            100                 105                 110         


Gly Tyr Glu His Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu 
        115                 120                 125             


Asn Ala Pro Gly Gly Pro Tyr Lys Ile Gly Thr Ser Gly Ser Cys Pro 
    130                 135                 140                 


Asn Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val 
145                 150                 155                 160 


Pro Lys Asn Asp Asn Asn Lys Thr Ala Thr Asn Ser Leu Thr Ile Glu 
                165                 170                 175     


Val Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly 
            180                 185                 190         


Phe His Ser Asp Xaa Glu Xaa Gln Met Ala Lys Leu Tyr Gly Asp Ser 
        195                 200                 205             


Lys Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr 
    210                 215                 220                 


Val Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu 
225                 230                 235                 240 


Pro Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly 
                245                 250                 255     


Lys Thr Gly Thr Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys 
            260                 265                 270         


Val Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro 
        275                 280                 285             


Leu Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn 
    290                 295                 300                 


Lys Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn 
305                 310                 315                 320 


Cys Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys 
                325                 330                 335     


Tyr Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg 
            340                 345         


<210>  147
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Malaysia/2506/20/03 HA2 Domain

<400>  147

Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly Ala His Gly Val 
            20                  25                  30          


Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile 
        35                  40                  45              


Thr Lys Asn Leu Asn Ser Leu Ser Glu Leu Glu Val Lys Asn Leu Gln 
    50                  55                  60                  


Arg Leu Ser Gly Ala Met Asp Glu Leu His Asn Glu Ile Leu Glu Leu 
65                  70                  75                  80  


Asp Glu Lys Val Asp Asp Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile 
                85                  90                  95      


Glu Leu Ala Val Leu Leu Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp 
            100                 105                 110         


Glu His Leu Leu Ala Leu Glu Arg Lys Leu Lys Lys Met Leu Gly Pro 
        115                 120                 125             


Ser Ala Val Glu Ile Gly Asn Gly Cys Phe Glu Thr Lys His Lys Cys 
    130                 135                 140                 


Asn Gln Thr Cys Leu Asp Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly 
145                 150                 155                 160 


Glu Phe Ser Leu Pro Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser 
                165                 170                 175     


Leu Asn Asp Asp Gly Leu Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser 
            180                 185                 190         


Thr Ala Ala Ser Ser Leu Ala Val Thr Leu Met Ile Ala Ile Phe Val 
        195                 200                 205             


Val Tyr Met Val Ser Arg Asp Asn Val Ser Cys Ser Ile Cys Leu 
    210                 215                 220             


<210>  148
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Malaysia/2506/20/03 HA Globular Head Domain


<220>
<221>  misc_feature
<222>  (155)..(155)
<223>  Xaa = Asn or Ser

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  Xaa = Asn, Ile, Thr or Ser

<400>  148

Asn Leu Lys Gly Thr Glu Thr Arg Gly Lys Leu Cys Pro Lys Cys Leu 
1               5                   10                  15      


Asn Cys Thr Asp Leu Asp Val Ala Leu Gly Arg Pro Lys Cys Thr Gly 
            20                  25                  30          


Asn Ile Pro Ser Ala Arg Val Ser Ile Leu His Glu Val Arg Pro Val 
        35                  40                  45              


Thr Ser Gly Cys Phe Pro Ile Met His Asp Arg Thr Lys Ile Arg Gln 
    50                  55                  60                  


Leu Pro Asn Leu Leu Arg Gly Tyr Glu His Ile Arg Leu Ser Thr His 
65                  70                  75                  80  


Asn Val Ile Asn Ala Glu Asn Ala Pro Gly Gly Pro Tyr Lys Ile Gly 
                85                  90                  95      


Thr Ser Gly Ser Cys Pro Asn Val Thr Asn Gly Asn Gly Phe Phe Ala 
            100                 105                 110         


Thr Met Ala Trp Ala Val Pro Lys Asn Asp Asn Asn Lys Thr Ala Thr 
        115                 120                 125             


Asn Ser Leu Thr Ile Glu Val Pro Tyr Ile Cys Thr Glu Gly Glu Asp 
    130                 135                 140                 


Gln Ile Thr Val Trp Gly Phe His Ser Asp Xaa Glu Xaa Gln Met Ala 
145                 150                 155                 160 


Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys Phe Thr Ser Ser Ala Asn 
                165                 170                 175     


Gly Val Thr Thr His Tyr Val Ser Gln Ile Gly Gly Phe Pro Asn Gln 
            180                 185                 190         


Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly Arg Ile Val Val Asp Tyr 
        195                 200                 205             


Met Val Gln Lys Ser Gly Lys Thr Gly Thr Ile Thr Tyr Gln Arg Gly 
    210                 215                 220                 


Ile Leu Leu Pro Gln Lys Val Trp Cys Ala Ser Gly Arg Ser Lys Val 
225                 230                 235                 240 


Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
                245                 250 


<210>  149
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Malaysia/2506/20/03 HA N-Terminal Segment of Stalk (encompasses
       alanine at interface with globular head domain)

<400>  149

Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser His Phe Ala 
        35                  40          


<210>  150
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Malaysia/2506/20/03 HA C-Terminal Segment of Stalk (encompasses
       alanine at interface with globular head domain)

<400>  150

Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
1               5                   10                  15      


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
            20                  25                  30          


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
        35                  40                  45              


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
    50                  55                  60                  


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
65                  70                  75                  80  


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
                85                  90                  95      


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
            100                 105                 110         


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
        115                 120                 125             


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
    130                 135                 140                 


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
145                 150                 155                 160 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
                165                 170                 175     


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
            180                 185                 190         


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
        195                 200                 205             


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
    210                 215                 220                 


Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn His 
225                 230                 235                 240 


Thr 
    


<210>  151
<211>  1824
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of mouse adapted Influenza 
       B/Malaysia/2506/2004 virus HA


<220>
<221>  misc_feature
<222>  (641)..(641)
<223>  n is a, c, g, or t

<400>  151
atgaaggcaa taattgtact actcatggta gtaacatcca atgcagatcg aatctgcact       60

gggataacat cgtcaaactc accacatgtt gtcaaaactg ctactcaagg ggaggtcaat      120

gtgactggtg taataccact gacaacaaca cccaccaaat ctcattttgc aaatctcaaa      180

ggaacagaaa ccagagggaa actatgccca aaatgcctca actgcacaga tctggacgtg      240

gccttgggca gaccaaaatg cacggggaac ataccctcgg caagagtttc aatactccat      300

gaagtcagac ctgttacatc tgggtgcttt cctataatgc acgacagaac aaaaattaga      360

cagctgccta accttctcag aggatacgaa catatcaggt tatcaactca taacgttatc      420

aatgcagaaa atgcaccagg aggaccctac aaaattggaa cctcagggtc ttgccctaac      480

gttaccaatg gaaacggatt tttcgcaaca atggcttggg ccgtcccaaa aaacgacaac      540

aacaaaacag caacaaattc attaacaata gaagtaccat acatttgtac agaaggagaa      600

gaccaaatta ccgtttgggg gttccactct gatarcgaaa nccaaatggc aaagctctat      660

ggggactcaa agccccagaa gttcacctca tctgccaacg gagtgaccac acattacgtt      720

tcacagattg gtggcttccc aaatcaaaca gaagacggag gactaccaca aagtggtaga      780

attgttgttg attacatggt gcaaaaatct gggaaaacag gaacaattac ctatcaaaga      840

ggtattttat tgcctcaaaa agtgtggtgc gcaagtggca ggagcaaggt aataaaagga      900

tccttgcctt taattggaga agcagattgc ctccacgaaa aatacggtgg attaaacaaa      960

agcaagcctt actacacagg ggaacatgca aaggccatag gaaattgccc aatatgggtg     1020

aaaacaccct tgaagctggc caatggaacc aaatatagac ctcctgcaaa actattaaag     1080

gaaaggggtt tcttcggagc tattgctggt ttcttagaag gaggatggga aggaatgatt     1140

gcaggttggc acggatacac atcccatggg gcacatggag tagcggtggc agcagacctt     1200

aagagcactc aagaggccat aaacaagata acaaaaaatc tcaactcttt gagtgagctg     1260

gaagtaaaga atcttcaaag actaagcggt gccatggatg aactccacaa cgaaatacta     1320

gaactagacg agaaagtgga tgatctcaga gctgatacaa taagctcaca aatagaactc     1380

gcagtcctgc tttccaatga aggaataata aacagtgaag atgagcatct cttggcgctt     1440

gaaagaaagc tgaagaaaat gctgggcccc tctgctgtag agatagggaa tggatgcttt     1500

gaaaccaaac acaagtgcaa ccagacctgt ctcgacagaa tagctgctgg tacctttgat     1560

gcaggagaat tttctctccc cacttttgat tcactgaata ttactgctgc atctttaaat     1620

gacgatggat tggataatca tactatactg ctttactact caactgctgc ctccagtttg     1680

gctgtaacat tgatgatagc tatctttgtt gtttatatgg tctccagaga caatgtttct     1740

tgctccatct gtctataagg aaagttaaac cctgtatttt cctttattgt agtgcttgtt     1800

tgcttgttac cattacaaaa aacg                                            1824


<210>  152
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full length amino acid sequence for influenza 
       B/Malaysia/2506/20/03 HA


<220>
<221>  misc_feature
<222>  (214)..(214)
<223>  Xaa = Ile or Thr

<400>  152

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Asn Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asn 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Lys Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Asp Asn Asn Lys Thr Ala Thr Asn Ser Leu Thr Ile Glu Val 
            180                 185                 190         


Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe 
        195                 200                 205             


His Ser Asp Asn Glu Xaa Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys 
    210                 215                 220                 


Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val 
225                 230                 235                 240 


Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro 
                245                 250                 255     


Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys 
            260                 265                 270         


Thr Gly Thr Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val 
        275                 280                 285             


Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu 
    290                 295                 300                 


Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys 
305                 310                 315                 320 


Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys 
                325                 330                 335     


Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr 
            340                 345                 350         


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
        355                 360                 365             


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
    370                 375                 380                 


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
385                 390                 395                 400 


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser 
                405                 410                 415     


Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met 
            420                 425                 430         


Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp 
        435                 440                 445             


Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
    450                 455                 460                 


Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
465                 470                 475                 480 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                485                 490                 495     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            500                 505                 510         


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
        515                 520                 525             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
    530                 535                 540                 


Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu 
545                 550                 555                 560 


Ala Val Thr Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg 
                565                 570                 575     


Asp Asn Val Ser Cys Ser Ile Cys Leu 
            580                 585 


<210>  153
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Malaysia/2506/20/03 HA signal peptide

<400>  153

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala 
1               5                   10                  15  


<210>  154
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Malaysia/2506/20/03 HA1 domain


<220>
<221>  misc_feature
<222>  (199)..(199)
<223>  Xaa = Ile or Thr

<400>  154

Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu 
        35                  40                  45              


Thr Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp 
    50                  55                  60                  


Val Ala Leu Gly Arg Pro Lys Cys Thr Gly Asn Ile Pro Ser Ala Arg 
65                  70                  75                  80  


Val Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro 
                85                  90                  95      


Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg 
            100                 105                 110         


Gly Tyr Glu His Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu 
        115                 120                 125             


Asn Ala Pro Gly Gly Pro Tyr Lys Ile Gly Thr Ser Gly Ser Cys Pro 
    130                 135                 140                 


Asn Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val 
145                 150                 155                 160 


Pro Lys Asn Asp Asn Asn Lys Thr Ala Thr Asn Ser Leu Thr Ile Glu 
                165                 170                 175     


Val Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly 
            180                 185                 190         


Phe His Ser Asp Asn Glu Xaa Gln Met Ala Lys Leu Tyr Gly Asp Ser 
        195                 200                 205             


Lys Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr 
    210                 215                 220                 


Val Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu 
225                 230                 235                 240 


Pro Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly 
                245                 250                 255     


Lys Thr Gly Thr Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys 
            260                 265                 270         


Val Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro 
        275                 280                 285             


Leu Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn 
    290                 295                 300                 


Lys Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn 
305                 310                 315                 320 


Cys Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys 
                325                 330                 335     


Tyr Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg 
            340                 345         


<210>  155
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Malaysia/2506/20/03 HA2 domain

<400>  155

Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly Ala His Gly Val 
            20                  25                  30          


Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile 
        35                  40                  45              


Thr Lys Asn Leu Asn Ser Leu Ser Glu Leu Glu Val Lys Asn Leu Gln 
    50                  55                  60                  


Arg Leu Ser Gly Ala Met Asp Glu Leu His Asn Glu Ile Leu Glu Leu 
65                  70                  75                  80  


Asp Glu Lys Val Asp Asp Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile 
                85                  90                  95      


Glu Leu Ala Val Leu Leu Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp 
            100                 105                 110         


Glu His Leu Leu Ala Leu Glu Arg Lys Leu Lys Lys Met Leu Gly Pro 
        115                 120                 125             


Ser Ala Val Glu Ile Gly Asn Gly Cys Phe Glu Thr Lys His Lys Cys 
    130                 135                 140                 


Asn Gln Thr Cys Leu Asp Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly 
145                 150                 155                 160 


Glu Phe Ser Leu Pro Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser 
                165                 170                 175     


Leu Asn Asp Asp Gly Leu Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser 
            180                 185                 190         


Thr Ala Ala Ser Ser Leu Ala Val Thr Leu Met Ile Ala Ile Phe Val 
        195                 200                 205             


Val Tyr Met Val Ser Arg Asp Asn Val Ser Cys Ser Ile Cys Leu 
    210                 215                 220             


<210>  156
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Malaysia/2506/20/03 HA N-Terminal Segment of Stalk (encompasses
       alanine at interface with globular head domain)

<400>  156

Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser His Phe Ala 
        35                  40          


<210>  157
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Malaysia/2506/20/03 HA C-Terminal Segment of Stalk (encompasses
       alanine at interface with globular head domain)

<400>  157

Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
1               5                   10                  15      


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
            20                  25                  30          


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
        35                  40                  45              


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
    50                  55                  60                  


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
65                  70                  75                  80  


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
                85                  90                  95      


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
            100                 105                 110         


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
        115                 120                 125             


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
    130                 135                 140                 


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
145                 150                 155                 160 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
                165                 170                 175     


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
            180                 185                 190         


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
        195                 200                 205             


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
    210                 215                 220                 


Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn His 
225                 230                 235                 240 


Thr 
    


<210>  158
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Malaysia/2506/20/03 HA Globular Head Domain


<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  Xaa = Ile or Thr

<400>  158

Asn Leu Lys Gly Thr Glu Thr Arg Gly Lys Leu Cys Pro Lys Cys Leu 
1               5                   10                  15      


Asn Cys Thr Asp Leu Asp Val Ala Leu Gly Arg Pro Lys Cys Thr Gly 
            20                  25                  30          


Asn Ile Pro Ser Ala Arg Val Ser Ile Leu His Glu Val Arg Pro Val 
        35                  40                  45              


Thr Ser Gly Cys Phe Pro Ile Met His Asp Arg Thr Lys Ile Arg Gln 
    50                  55                  60                  


Leu Pro Asn Leu Leu Arg Gly Tyr Glu His Ile Arg Leu Ser Thr His 
65                  70                  75                  80  


Asn Val Ile Asn Ala Glu Asn Ala Pro Gly Gly Pro Tyr Lys Ile Gly 
                85                  90                  95      


Thr Ser Gly Ser Cys Pro Asn Val Thr Asn Gly Asn Gly Phe Phe Ala 
            100                 105                 110         


Thr Met Ala Trp Ala Val Pro Lys Asn Asp Asn Asn Lys Thr Ala Thr 
        115                 120                 125             


Asn Ser Leu Thr Ile Glu Val Pro Tyr Ile Cys Thr Glu Gly Glu Asp 
    130                 135                 140                 


Gln Ile Thr Val Trp Gly Phe His Ser Asp Asn Glu Xaa Gln Met Ala 
145                 150                 155                 160 


Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys Phe Thr Ser Ser Ala Asn 
                165                 170                 175     


Gly Val Thr Thr His Tyr Val Ser Gln Ile Gly Gly Phe Pro Asn Gln 
            180                 185                 190         


Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly Arg Ile Val Val Asp Tyr 
        195                 200                 205             


Met Val Gln Lys Ser Gly Lys Thr Gly Thr Ile Thr Tyr Gln Arg Gly 
    210                 215                 220                 


Ile Leu Leu Pro Gln Lys Val Trp Cys Ala Ser Gly Arg Ser Lys Val 
225                 230                 235                 240 


Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
                245                 250 


<210>  159
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Malaysia/2506/20/03 HA Ectodomain


<220>
<221>  misc_feature
<222>  (199)..(199)
<223>  Xaa = Ile or Thr

<400>  159

Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu 
        35                  40                  45              


Thr Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp 
    50                  55                  60                  


Val Ala Leu Gly Arg Pro Lys Cys Thr Gly Asn Ile Pro Ser Ala Arg 
65                  70                  75                  80  


Val Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro 
                85                  90                  95      


Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg 
            100                 105                 110         


Gly Tyr Glu His Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu 
        115                 120                 125             


Asn Ala Pro Gly Gly Pro Tyr Lys Ile Gly Thr Ser Gly Ser Cys Pro 
    130                 135                 140                 


Asn Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val 
145                 150                 155                 160 


Pro Lys Asn Asp Asn Asn Lys Thr Ala Thr Asn Ser Leu Thr Ile Glu 
                165                 170                 175     


Val Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly 
            180                 185                 190         


Phe His Ser Asp Asn Glu Xaa Gln Met Ala Lys Leu Tyr Gly Asp Ser 
        195                 200                 205             


Lys Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr 
    210                 215                 220                 


Val Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu 
225                 230                 235                 240 


Pro Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly 
                245                 250                 255     


Lys Thr Gly Thr Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys 
            260                 265                 270         


Val Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro 
        275                 280                 285             


Leu Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn 
    290                 295                 300                 


Lys Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn 
305                 310                 315                 320 


Cys Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys 
                325                 330                 335     


Tyr Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala 
            340                 345                 350         


Ile Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp 
        355                 360                 365             


His Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp 
    370                 375                 380                 


Leu Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn 
385                 390                 395                 400 


Ser Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala 
                405                 410                 415     


Met Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp 
            420                 425                 430         


Asp Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu 
        435                 440                 445             


Leu Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala 
    450                 455                 460                 


Leu Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile 
465                 470                 475                 480 


Gly Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu 
                485                 490                 495     


Asp Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro 
            500                 505                 510         


Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly 
        515                 520                 525             


Leu Asp Asn His Thr 
    530             


<210>  160
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NP epitope from H1N1pdm09 (A/Cal/04)

<400>  160

Ala Ser Asn Glu Asn Val Glu Thr Met 
1               5                   


<210>  161
<211>  2312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse adapted Influenza B/Malaysia/2506/2004 virus PB1

<400>  161
aatataaatc cttatttcct cttcatagat gtgcccatac aggcagcaat ttcaacaaca       60

ttcccataca ctggtgttcc cccttattcc catggaacgg gaacaggcta cacaatagac      120

accgtgatca gaacacatga gtactcaarc aaggggaaac agtacatttc tgatgttaca      180

ggatgcacaa tggtagatcc aacaaatggc ccattacccg aagataatga gccgagtgcc      240

tatgcgcaat tagattgcgt tttagaggct ttggatagaa tggatgaaga acacccaggt      300

ctgtttcaag cagcctcaca gaatgctatg gaggccctaa tggtcacaac tgtagacaaa      360

ttaacccagg ggagacagac ttttgattgg acagtatgca gaaaccaacc tgctgcaacg      420

gcactgaaca caacaataac ctcttttagg ttgaatgatt taaatggagc cgacaaaggt      480

ggattagtac ctttttgcca ggatatcatt gattcattag acagacctga aatgactttc      540

ttctcagtaa agaatataaa gaaaaaattg cctgccaaaa acagaaaggg tttcctcata      600

aagaggatac caatgaaggt aaaggacaaa ataaccaaag tggaatacat caaaagagca      660

ttatcattaa acacaatgac aaaagacgct gaaagaggca aactaaaaag aagagcgatt      720

gccaccgctg gaatacaaat cagagggttt gtattagtag ttgaaaactt ggctaaaaat      780

atatgtgaaa atctagaaca aagtggttta ccagtaggtg gaaacgagaa gaaagccaaa      840

ctgtcaaacg cagtggcaaa aatgctcagt aactgcccac ctggagggat cagcatgaca      900

gtaacaggag acaatactaa atggaatgaa tgtttaaacc caagaatctt tttggctatg      960

actgaaagaa taaccagaga cagcccaatt tggttcaggg atttttgtag tatagcaccg     1020

gtcctgttct ccaataagat agccagattg gggaaagggt ttatgataac aagcaaaaca     1080

aagagactga aggctcaaat accttgtcct gatctgttta gtatatcatt agaaagatat     1140

aatgaagaaa caagggcaaa attgaaaaag ctaaaaccat tcttcaatga agaaggaact     1200

gcatctttgt cacctgggat gatgatggga atgtttaata tgctatctac cgtgttgggg     1260

gtagctgcac taggtatcaa gaacattgga aacaaagaat acttatggga tggactgcaa     1320

tcttctgatg attttgctct atttgttaat gcaaaggatg aagaaacatg tatggaagga     1380

ataaacgact tttaccgaac atgtaaatta ttgggaataa acatgagcaa aaagaaaagt     1440

tactgtaatg agactggaat gtttgaattt acaagcatgt tctacagaga tggatttgta     1500

tctaattttg caatggaact cccttcattt ggggttgctg gagtaaatga atcagcagat     1560

atggcaatag ggatgacaat aataaagaac aacatgatca acaatggaat gggtccggca     1620

acagcacaaa cagccataca gttattcata gctgattata gatacaccta caaatgccac     1680

aggggagatt ccaaagtaga gggaaagaga atgaaaatca taaaggagtt atgggaaaac     1740

actaaaggaa gagatggtct attagtagca gatggtgggc ccaacattta caatttgaga     1800

aacttgcata ttccagaaat agtattaaag tataacttaa tggaccctga atacaaaggg     1860

cggttacttc atcctcaaaa tccctttgtg ggacatttgt ctattgaggg catcaaagag     1920

gcagatataa ccccagcaca tggtccagta aagaaaatgg actacgatgc ggtgtctgga     1980

actcatagtt ggagaaccaa aagaaacaga tctatactaa acactgatca gaggaacatg     2040

attcttgagg aacaatgcta cgctaagtgt tgcaacctat ttgaggcctg ttttaacagt     2100

gcatcataca ggaagccagt gggtcaacat agcatgcttg aggctatggc ccacagatta     2160

agaatggatg cacgattaga ttatgaatca ggaagaatgt caaaggatga ttttgagaaa     2220

gcaatggctc accttggtga gattgggtac atataagctt cgaagatgtc tatggggtta     2280

ttggtcatca ttgaatacat gcgatacaca aa                                   2312


<210>  162
<211>  2358
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse adapted Influenza B/Malaysia/2506/2004 virus PB2

<400>  162
ttcaagatga cattggccaa aattgaattg ttaaaacaac tgctaaggga caatgaagcc       60

aaaacagttt tgaagcaaac aacggtagac caatataaca taataagaaa attcaataca      120

tcaaggattg aaaagaatcc ttcactaagg atgaaatggg ccatgtgttc taattttccc      180

ttggctctaa ccaagggcga catggcaaat agaatcccct tggaatacaa aggaatacaa      240

cttaaaacaa atgctgaaga cataggaacc aaaggccaaa tgtgctcaat agcagcagtt      300

acttggtgga atacatatgg accaatagga gatactgaag gtttcgaaag ggtctacgaa      360

agcttttttc tcagaaaaat gagacttgac aatgccactt ggggccgaat aacttttggc      420

ccagttgaaa gagtgagaaa aagggtactg ctaaaccctc tcaccaagga aatgcctcca      480

gatgaggcga gcaatgtgat aatggaaata ttgttcccta aagaagcagg aataccaaga      540

gaatccactt ggatacatag rgaactgata aaagaaaaaa gagaaaaatt gaaaggaaca      600

atgataactc caatcgtact ggcatacatg cttgaaagag aactggttgc tcgaagaaga      660

ttcttgccag tggcaggagc aacatcagct gagttcatag aaatgctaca ctgcttacaa      720

ggtgaaaatt ggagacaaat atatcaccca ggagggaata aattaactga gtctaggtct      780

caatcaatga tagtagcttg tagaaaaata atcagaagat caatagtcgc ttcaaaccca      840

ctggagctag ctgtagaaat tgcaaacaag actgtgatag atactgaacc tttaaagtca      900

tgtctggcag ccatagacgg aggtgatgta gcttgtgaca taataagagc tgcattagga      960

ctaaagatca gacaaagaca aagatttgga cggcttgagt taaaaagaat atcaggaaga     1020

ggattcaaaa atgatgaaga aatattaata gggaacggaa caatacagaa gattggaata     1080

tgggacgggg aagaggagtt ccatgtaaga tgtggtgaat gcaggggaat attaaaaaag     1140

agtaaaatga aactggaaaa actactaata aattcagcca aaaaggagga catgagagat     1200

ttaataatct tatgcatggt attttctcaa gacactagga tgttccaagg ggtgagagga     1260

gaaataaatt ttcttaatcg agcaggccaa cttttatctc caatgtacca actccaacga     1320

tattttttga atagaagcaa cgaccttttt gatcaatggg ggtatgagga atcacccaaa     1380

gcaagtgaac tatatgggat aaatgaatca atgaatgcat ctgactatac attgaaaggg     1440

gttgtagtga caagaaatgt aattgacgac tttagctcta ctgaaacaga aaaagtatcc     1500

ataacaaaaa atcttagttt aataaaaagg actggggaag tcataatggg agctaatgac     1560

gtgagtgaat tagaatcaca agcacagctg atgataacat atgatacacc taagatgtgg     1620

gaaatgggaa caaccaaaga actggtgcaa aacacttatc aatgggtgct aaaaaacttg     1680

gtaacactga aggctcagtt tcttctagga aaagaggaca tgttccaatg ggatgcattt     1740

gaagcatttg agagcataat tcctcagaag atggctggtc agtacagtgg atttgcaaga     1800

gcagtgctca aacaaatgag agaccaggag gttatgaaaa ctgaccagtt cataaagttg     1860

ttgccttttt gtttctcacc accaaaatta aggagcaatg gggagcctta tcaattctta     1920

aaacttgtat tgaaaggagg aggggaaaat ttcatcgaag taaggaaagg gtcccctcta     1980

ttttcctata atccacaaac agaagtccta accatatgcg gcagaatgat gtcattaaaa     2040

gggaaaattg aagatgaaga aaggaataga tcaatgggga atgcagtatt agcaggcttt     2100

ctcgttagtg gcaagtatga cccagatctt ggagatttca aaactattga agaacttgaa     2160

aggctgaaac cgggggaaaa ggcaaatatc ttactttatc aaggaaagcc agttaaagta     2220

gttaaaagga aaaggtatag tgctttgtcc aatgacattt cacaaggaat taagagacaa     2280

agaatgacag ttgagtccat ggggtgggcc ttgagctaat ataaatttat ccattaattc     2340

aatgaacgca attgagtg                                                   2358


<210>  163
<211>  2248
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse adapted Influenza B/Malaysia/2506/2004 virus PA

<400>  163
atacttttat tacaagaaac ttccaaacta caataataca aaaggccaga aacacaatgg       60

cagaatttag tgaagatcct gaattacaac cagcaatgct attcaatatc tgcgtccatc      120

tagaggtttg ctatgtaata agtgacatga attttcttga cgaagaagga aaagcatata      180

cagcattaga aggacaaggg aaagaacaaa atttgagacc acaatatgaa gtaattgagg      240

gaatgccaag aaccatagca tggatggtcc aaagatcctt agctcaagag catggaatag      300

agactcccaa gtatctggct gatttgtttg attataaaac caagagattt atagaagttg      360

gaataacaaa aggattggct gatgattact tttggaaaaa gaaagaaaag ttgggaaata      420

gcatggaact gatgatattc agctacaatc aagactactc gttaagtaat gaatcctcat      480

tggatgagga agggaaaggg agagtgctaa gcagactcac agaacttcag gctgaattaa      540

gtctgaaaaa cctatggcaa gttctcatag gagaagaaga tgttgaaaag ggaattgact      600

ttaaacttgg acaaacaata tctagactaa gggatatatc tgttcccgct ggtttctcca      660

attttgaagg aatgaggagc tacatagaca atatagaccc aaaaggagca atagagagaa      720

atctagcaag gatgtctccc ttagtatcag tcacacctaa aaagttgaca tgggaggacc      780

taagaccaat agggcctcac atttacaacc atgagctacc agaagttcca tataatgcct      840

ttcttctaat gtctgatgaa ctggggctgg ccaatatgac tgagggaaag tccaaaaaac      900

cgaagacatt agccaaagaa tgtctagaaa agtactcaac actacgggat caaactracc      960

caatattaat aatgaaaagc gaaaaagcta atgaaaattt cctatggaag ctttggagag     1020

actgtgtaaa tacaataagt aatgaggaaa tgagtaacga gttacagaaa accaattatg     1080

ccaagtgggc cacaggggat ggattaacat accagaaaat aatgaaagaa gtagcaatag     1140

atgacgaaac aatgtgccaa gaagagccta aaatccctaa taaatgtaga gtggctgctt     1200

gggttcaaac agagatgaat ctattgagca ctctgacaag taaaagagct ctggacctac     1260

cagaaatagg gccagacgta gcacccgtgg agcatgtagg gagtgaaaga aggaaatact     1320

ttgttaatga aatcaactac tgtaaggcct ctacagttat gatgaagtat gtgctttttc     1380

acacttcatt gttgaatgaa agcaatgcca gcatgggaaa atacaaagta ataccaataa     1440

ccaatagagt agtaaatgaa acaggagaaa gtttcgacat gctttatggt ctggcggtta     1500

aaggacaatc tcatctgagg ggagatactg atgttgtaac agttgtaact ttcgaattta     1560

gtagtacaga cccaagagtg gactcaggaa agtggccaaa atatactgtg tttaggattg     1620

gctccctatt tgtgagtggg agggaaaaat ctgtgtacct gtattgccga gtgaatggca     1680

caaataagat ccaaatgaaa tggggaatgg aagctagaag atgtctgctt caatcaatgc     1740

aacaaatgga agcaattgtt gaacaggaat catcgataca gggatatgac atgaccaagg     1800

cttgtttcaa gggagacaga gtaaatagcc ccaaaacttt cagtattgga actcaagaag     1860

ggaaactagt aaaaggatcc tttggaaaag cactaagagt aatatttact aaatgtttga     1920

tgcactatgt atttggaaat gcccaattgg aggggtttag tgccgagtct aggagacttc     1980

tactgttgat ccaagcatta aaggacagaa agggcccttg ggtgttcgac ttagagggaa     2040

tgtattctgg aatagaagaa tgtattagca acaacccttg ggtaatacag agtgcatact     2100

ggtttaatga atggttgggc tttgaaaagg aggggagtaa agtgttagaa tcagtggatg     2160

aaataatgga tgaataaaag gacatggtac tcaatttggt actattttgt tcattatgta     2220

tctaaacatc caataaaaag aaccaaga                                        2248


<210>  164
<211>  1772
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse adapted Influenza B/Malaysia/2506/2004 virus NP

<400>  164
caacaaaaga actgaaaatc aaaatgtcca acatggatat tgacggtatc aacactggga       60

caattgacaa agcaccggaa gaaataactt ctggaaccag tgggacaacc agaccaatca      120

tcagaccagc aacccttgcc ccaccaagca acaaacgaac ccggaaccca tccccggaaa      180

gagcaaccac aatcagtgaa gctgatgtcg gaaggaaaac ccaaaagaaa cagaccccga      240

cagagataaa gaagagcgtc tacaatatgg tagtgaaact gggtgaattc tataaccaga      300

tgatggtcaa agctggactt aacgatgaca tggagagaaa cctaattcaa aatgcgcatg      360

ctgtggaaag aattctattg gctgccactg atgacaagaa aactgaattc cagaagaaaa      420

agaatgccag agatgtcaaa gaagggaaag aagaaataga tcacaacaaa acagggggca      480

ccttttacaa gatggtaaga gatgataaaa ccatctactt cagccctata agagtcacct      540

ttttaaaaga agaagtaaaa acaatgtaca aaaccaccat ggggagtgat ggcttcagcg      600

gactaaatca cataatgatt gggcattcac agatgaatga tgtctgtttc caaagatcaa      660

aggcactaaa aagagttgga cttgaccctt cattaatcag tacctttgca ggaagcacac      720

tccccagaag atcaggtgca actggtgttg cgatcaaagg aggtggaact ctagtggctg      780

aagccattcg atttatagga agagcaatgg cagacagagg gctattgaga gacatcaaag      840

ccaagactgc gtatgaaaag attcttctga acctaaaaaa caaatgctct gcgccccaac      900

agaaggctct agttgatcaa gtgatcggaa gtagaaatcc agggattgca gacattgaag      960

acctaaccct acttgctcgt agtatggtcg ttgttaggcc ctctgtggcg agcaaagtag     1020

tgcttcccat aagcatttac gccaaaatac ctcaactagg gttcaacgtt gaagagtact     1080

ctatggttgg gtatgaagcc atggctcttt acaatatggc aacacctgtt tccatattaa     1140

gagtgggaga tgatgcaaag gacaaatcac aattattctt catgtcttgc ttcggagctg     1200

cctatgaaga cctgagagtt ttgtctgcat taacaggcac agaattcaag cctagatcag     1260

cattaaaatg caagggtttc catgttccag caaaggaaca ggtggaagga atgggggcag     1320

ctctgatgtc catcaagctc cagttttggg ctccaatgac cagatctggg ggaaacgaag     1380

taggtggaga cggggggtct ggccaaataa gttgcagccc agtgtttgca gtagaaagac     1440

ctattgctct aagcaagcaa gctgtaagaa gaatgctgtc aatgaatatt gagggacgtg     1500

atgcagatgt caaaggaaat ctactcaaga tgatgaatga ctcaatggct aagaaaacca     1560

atggaaatgc tttcattggg aagaaaatgt ttcaaatatc agacaaaaac aaaaccaatc     1620

ccgttgaaat tccaattaag caaaccatcc ccaatttctt ctttgggagg gacacagcag     1680

aggattatga tgacctcgat tattaaagca acaaaataga cactatgact gtgattgttt     1740

caatacgttt ggaatgtggg tgtttactct ta                                   1772


<210>  165
<211>  1483
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse adapted Influenza B/Malaysia/2506/2004 virus NA

<400>  165
aaatgaacaa tgctaccttc aactatacaa acgttaaccc tatttctcac atcaggggga       60

gtattattat cactatatgt gtcagcttca ttgtcatact tactatattc ggatatattg      120

ctaaaattcc catcaacaga aattactgca ccaacaatgc cattggattg tgcaaacgca      180

tcaaatgttc aggctgtgaa ccgttctgca acaaaagggg tgacacttct tctcccagaa      240

ccggagtgga catacccgcg tttatcttgc ccgggctcaa cctttcagaa agcactccta      300

attagccctc atagattcgg agaaaccaaa ggaaactcag ctcccttgat aataagggaa      360

ccttttattg cttgtggacc aaaggaatgc aaacactttg ctctaaccca ctatgcagcc      420

caaccagggg gatactacaa tggaacaaga ggagacagaa acaagctgag gcatctaatt      480

tcagtcaaat tgggcaaaat cccaacagta gaaaactcca ttttccacat ggcagcatgg      540

agcgggtccg catgccatga tggtaaggaa tggacatata tcggagttga tggccctgac      600

aataatgcat tgctcaaaat aaaatatgga gaagcatata ctgacacata ccattcctat      660

gcaaacaaca tcctaagaac acaagaaagt gcctgcaatt gcatcggggg aaattgttat      720

cttatgataa ctgatggctc agcttcaggt gttagtgaat gcagatttct taagattcga      780

gagggccgaa taataaaaga aatatttcca acaggaagaa taaaacatac tgaagaatgc      840

acatgcggat ttgctagcaa taaaaccata gaatgtgcct gtagagataa cagttacaca      900

gcaaaaagac cctttgtcaa attaaacgtg gagactgata cagcagaaat aagattgatg      960

tgcacagaga cttatttgga cacccccaga ccagatgatg gaagcataac agggccttgt     1020

gaatctaatg gggacaaagg gagtggaggc atcaagggag gatttgtcca tcaaagaatg     1080

gcatccaaga ttggaaggtg gtactctcga acgatgtcta aaactaaaag gatggggatg     1140

gggctgtatg tcaartatga tggagaccca tgggctgaca gtgatgccct tgcttttagt     1200

ggagtaatgg tttcaatgga agaacctggt tggtactcct ttggcttcga aataaaagac     1260

aagaaatgtg atgtcccctg tattgggata gagatggtac atgatggtgg aaaagagact     1320

tggcactcag cagctacagc catttactgt ttaatgggct caggacagct gctgtgggac     1380

actgtcacag gtgttaatat ggctctgtaa tggaggaatg gttgagtctg ttctaaaccc     1440

tttgttccta ttttgtttga acaattgtcc ttactgaact taa                       1483


<210>  166
<211>  1140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse adapted Influenza B/Malaysia/2506/2004 virus M

<400>  166
cgctgtttgg agacacaatt gcctacctgc tttcattgac agaagatgga gaaggcaaag       60

cagaactagc agaaaaatta cactgttggt ttggtgggaa agaatttgac ctagactctg      120

ccttggaatg gataaaaaac aaaagatgct taactgatat acaaaaagca ctaattggtg      180

cctctatatg ctttttaaaa cccaaagacc aggaaagaaa aagaagattc atcacagaac      240

ccttatcagg aatgggaaca acagcaacaa aaaagaaagg cctgattctg gctgagagaa      300

aaatgagaag atgtgtgagc tttcatgaag catttgaaat agcagaaggc catgaaagct      360

cagcgctact atactgtctc atggtcatgt acctgaatcc tggaaattat tcaatgcaag      420

taaaactagg aacgctctgt gctttatgcg agaaacaagc atcacattca cacagggctc      480

atagcagagc agcgagatct tcagtgcctg gagtgagacg agaaatgcag atggtctcag      540

ctatgaacac agcgaaaaca atgaatggaa tgggaaaagg agaagacgtc caaaagctgg      600

cagaagagct gcaaagcaac attggagtgc tgagatctct tggggcaagt caaaagaatg      660

gggaaggaat tgcaaargat gtaatggaag tgctaaagca gagctctatg ggaaattcag      720

ctcttgtgaa gaaatatcta taatgctcga accatttcag attctttcaa tttgttcttt      780

tatcttatca gctctccatt tcatggcttg gacaataggg catttgaatc aaataaaaag      840

aggaataaac atgaaaatac gaataaaagg tccaaacaaa gagacaataa acagagaggt      900

atcaattttg agacacagtt accaaaaaga aatccaggcc aaagaaacaa tgaaggaagt      960

actctctgac aacatggagg tattgagtga ccacataata attgaggggc tttctgccga     1020

agagataata aaaatgggtg aaacagtttt ggagatagaa gaattgcatt aaattcaatt     1080

tttactgtat ttcttactat gcatttaagc aaattgtaat caatgtcagc aaataaactg     1140


<210>  167
<211>  1033
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse adapted Influenza B/Malaysia/2506/2004 virus NS

<400>  167
cgaacaacat gaccacaaca caaattgagg tgggtccggg agcaaccaat gccaccataa       60

actttgaagc aggaattctg gagtgctatg aaaggctttc atggcaaaga gcccttgact      120

accctggtca agaccgccta aacagactaa agagaaaatt agagtcaaga ataaagactc      180

acaacaaaag tgagcctgaa agtaaaagga tgtcccttga agagagaaaa gcaattggag      240

taaaaatgat gaaagtactc ctatttatgg atccgtctgc tggaattgaa gggtttgagc      300

catactgtat gaaaagttcc tcaaatagca actgtacgaa atacaattgg accgattacc      360

cttcaacacc agggaggtgc cttgatgaca tagaagaaga accagaggat gttgatggcc      420

caactgaaat agtattaagg gacatgaaca acaaagatgc aaggcaaaag ataaaggagg      480

aagtaaacac tcagaaagaa gggaagttcc gtttgacaat aaaaagggat atgcgtaatg      540

tattgtcctt gagagtgttg gtaaacggaa cattcctcaa acatcccaat ggatacaagt      600

ccttatcaac tctgcataga ttgaatgcat atgaccagag tggaaggctt gttgctaaac      660

ttgttgctac tgatgatctt acagtggagg atgaagaaga tggccatcgg atcctcaact      720

cactcttcga gcgtcttaat gaaggacatt caaagccaat tcgagcagct gaaactgcgg      780

tgggagtctt atcccaattt ggtcaagagc accgattatc accagaagag ggagacaatt      840

agactggtca cggaagaact ttatctttta agtaaaagaa ttgatgataa catattgttc      900

cacaaaacag taatagctaa cagctccata atagctgaca tggttgtatc attatcatta      960

ttagaaacat tgtatgaaat gaaggatgta gttgaagtgt acagcaggca gtgcttgtga     1020

atttaaaata aaa                                                        1033


<210>  168
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 120 loop substituted with amino acids 
       from A/black headed gull/Sweden/1/99

<400>  168

Arg Ile Glu Leu Ser Thr His Asn Val Ile Asn Ala Glu Val Ala Pro 
1               5                   10                  15      


Gly Gly Pro Tyr Arg Leu 
            20          


<210>  169
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza B/Hong Kong/8/73 virus HA

<400>  169

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Gln Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Met Gly Thr Ile Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Lys Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Asn Ile Arg Leu Ser Ala Arg Asn Val Thr Asn Ala Glu Thr 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Ile Val Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Val Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asp Glu Thr Gln Met Val Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Ala Glu Asp Glu Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Ala Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn His 
    530                 535                 540                 


Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val Thr 
545                 550                 555                 560 


Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp Asn Val 
                565                 570                 575     


Ser Cys Ser Ile Cys Leu 
            580         


<210>  170
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza A/Puerto Rico/8/34 virus HA

<400>  170

Met Lys Ala Asn Leu Leu Val Leu Leu Ser Ala Leu Ala Ala Ala Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Asp Pro Leu Leu Pro Val Arg Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Ser Glu Asn Gly Ile Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Asn 
    130                 135                 140                 


Thr Asn Gly Val Thr Ala Ala Cys Ser His Glu Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Glu Gly Ser Tyr Pro Lys 
                165                 170                 175     


Leu Lys Asn Ser Tyr Val Asn Lys Lys Gly Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Ile His His Pro Pro Asn Ser Lys Glu Gln Gln Asn Ile Tyr 
        195                 200                 205             


Gln Asn Glu Asn Ala Tyr Val Ser Val Val Thr Ser Asn Tyr Asn Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Arg Asp Gln Ala 
225                 230                 235                 240 


Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Lys Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Met Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser Met 
        275                 280                 285             


His Glu Cys Asn Thr Lys Cys Gln Thr Pro Leu Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Tyr Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Thr Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Thr Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Ile Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Val Asp Gly Val Lys Leu Glu Ser Met Gly Ile Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


Cys Arg Ile Cys Ile 
                565 


<210>  171
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza B/Yamagata/16/88 virus HA

<400>  171

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Met Gly Thr Ile Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Asn Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Arg 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Glu Ser Cys Pro Asn 
145                 150                 155                 160 


Val Thr Ser Arg Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Arg Asp Asn Lys Thr Ala Thr Asn Pro Leu Thr Val Glu Val Pro Tyr 
            180                 185                 190         


Ile Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser 
        195                 200                 205             


Asp Asn Lys Asn Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn Pro Gln 
    210                 215                 220                 


Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln 
225                 230                 235                 240 


Ile Gly Asp Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser 
                245                 250                 255     


Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr Gly 
            260                 265                 270         


Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp Cys 
        275                 280                 285             


Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly 
    290                 295                 300                 


Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys 
305                 310                 315                 320 


Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile 
                325                 330                 335     


Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro 
            340                 345                 350         


Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly 
        355                 360                 365             


Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr 
    370                 375                 380                 


Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser 
385                 390                 395                 400 


Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser 
                405                 410                 415     


Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu 
            420                 425                 430         


Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg 
        435                 440                 445             


Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn 
    450                 455                 460                 


Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg 
465                 470                 475                 480 


Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn Gly 
                485                 490                 495     


Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile 
            500                 505                 510         


Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp 
        515                 520                 525             


Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn 
    530                 535                 540                 


His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val 
545                 550                 555                 560 


Thr Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp Asn 
                565                 570                 575     


Val Ser Cys Ser Ile Cys Leu 
            580             


<210>  172
<211>  1742
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding influenza A/mallard/Sweden/24/2002 virus HA

<400>  172
gcaaaagcag gggtcacaat ggagaagttc atcataatgg caatgctctt ggtgagcaca       60

aatgcatatg ataggatatg cattggatac caatcaaaca actccactga cacagtaaac      120

acactcatag agcaaaatgt gccagtcacc cagacaatgg aactagtgga aaccgagaaa      180

catcctgcct attgcaatac tgatttgggt gctccactag agttgcgtga ttgcaagatt      240

gaggcggtga tctatgggaa cccaaaatgt gacatccact tgaaagacca aggttggtca      300

tacatagtgg agagacccag tgcaccagag gggatgtgct accctggatc agtggagaat      360

ctcgaagagt tgaggtttgt tttctccagt gctgcttcct acaaaaggat aagattgttt      420

gattactcca gatggaatgt taccagatct gggacaagca aggcatgcaa tgcttcaaca      480

ggaggccaat ctttctatcg gagcatcaat tggctaacta aaaagaaacc cgacacctat      540

gacttcaatg aggggactta tatcaataat gaagatgggg acataatttt cttatggggg      600

attcatcacc caccggatgc aaaagagcaa acaacactgt acaagaatgc aaatactttg      660

agtagtgtta ctaccaacac tataaacagg agcttccaac ccaatatcgg gcccaggcca      720

ctggtgagag ggcaacaagg gcggatggac tattattggg gcattttgaa gaggggagaa      780

actttaaaaa ttagaaccaa tgggaacctg atcgcgcctg aattcggtta tctgctcaaa      840

ggggagagcc atggcagaat aattcaaaat gaggacatac caattgggag ttgtcacacg      900

aaatgtcaga catacgcagg agcaattaat agcagcaaac cctttcagaa trcaagcagg      960

cactacatgg gagaatgtcc caagtatgtg aagaaggaaa gcttacggct ggcagttgga     1020

cttagaaaca ctccttctat tgaacccaga ggcttgtttg gagccattgc tggttttatt     1080

gaagggggat ggtctgggat gattgatgga tggtatgggt ttcaccatag taattcagaa     1140

ggaacaggaa tggcggccga tcagaaatcg acacaagaag caattgacaa aatcaccaat     1200

aaggtcaata atatagttga taaaatgaac agggaatttg aagtagtgaa ccatgagttt     1260

tccgaagtcg aaaaaagaat aaacatgata aatgacaaaa ttgatgacca gattgaagat     1320

ctttgggcct acaatgcaga gcttctggtc ctcctagaga accagaaaac actggatgaa     1380

cacgactcca atgtcaaaaa tctctttgat gaagtaagaa ggagactttc agccaatgca     1440

atagatactg ggaatggctg cttcgacata ctccacaaat gtgacaacga gtgcatggag     1500

accataaaga atgggactta taaccataaa gagtatgagg aagaggccaa gctggaaagg     1560

agcaagatta acggagtaaa gctagaggaa aataccacct ataaaattct cagcatttac     1620

agtacggtgg cggccagtct ttgcttggca atcctgattg ctggaggtct aatcctgggc     1680

atgcaaaatg gatcttgtag atgcatgttc tgtatttaag aaaaaacacc cttgtttcta     1740

ct                                                                    1742


<210>  173
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  influenza A/mallard/Sweden/24/2002 virus HA


<220>
<221>  misc_feature
<222>  (312)..(312)
<223>  Xaa = any naturally occurring amino acid

<400>  173

Met Glu Lys Phe Ile Ile Met Ala Met Leu Leu Val Ser Thr Asn Ala 
1               5                   10                  15      


Tyr Asp Arg Ile Cys Ile Gly Tyr Gln Ser Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asn Thr Leu Ile Glu Gln Asn Val Pro Val Thr Gln Thr Met Glu 
        35                  40                  45              


Leu Val Glu Thr Glu Lys His Pro Ala Tyr Cys Asn Thr Asp Leu Gly 
    50                  55                  60                  


Ala Pro Leu Glu Leu Arg Asp Cys Lys Ile Glu Ala Val Ile Tyr Gly 
65                  70                  75                  80  


Asn Pro Lys Cys Asp Ile His Leu Lys Asp Gln Gly Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Arg Pro Ser Ala Pro Glu Gly Met Cys Tyr Pro Gly Ser Val 
            100                 105                 110         


Glu Asn Leu Glu Glu Leu Arg Phe Val Phe Ser Ser Ala Ala Ser Tyr 
        115                 120                 125             


Lys Arg Ile Arg Leu Phe Asp Tyr Ser Arg Trp Asn Val Thr Arg Ser 
    130                 135                 140                 


Gly Thr Ser Lys Ala Cys Asn Ala Ser Thr Gly Gly Gln Ser Phe Tyr 
145                 150                 155                 160 


Arg Ser Ile Asn Trp Leu Thr Lys Lys Lys Pro Asp Thr Tyr Asp Phe 
                165                 170                 175     


Asn Glu Gly Thr Tyr Ile Asn Asn Glu Asp Gly Asp Ile Ile Phe Leu 
            180                 185                 190         


Trp Gly Ile His His Pro Pro Asp Ala Lys Glu Gln Thr Thr Leu Tyr 
        195                 200                 205             


Lys Asn Ala Asn Thr Leu Ser Ser Val Thr Thr Asn Thr Ile Asn Arg 
    210                 215                 220                 


Ser Phe Gln Pro Asn Ile Gly Pro Arg Pro Leu Val Arg Gly Gln Gln 
225                 230                 235                 240 


Gly Arg Met Asp Tyr Tyr Trp Gly Ile Leu Lys Arg Gly Glu Thr Leu 
                245                 250                 255     


Lys Ile Arg Thr Asn Gly Asn Leu Ile Ala Pro Glu Phe Gly Tyr Leu 
            260                 265                 270         


Leu Lys Gly Glu Ser His Gly Arg Ile Ile Gln Asn Glu Asp Ile Pro 
        275                 280                 285             


Ile Gly Ser Cys His Thr Lys Cys Gln Thr Tyr Ala Gly Ala Ile Asn 
    290                 295                 300                 


Ser Ser Lys Pro Phe Gln Asn Xaa Ser Arg His Tyr Met Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Lys Glu Ser Leu Arg Leu Ala Val Gly Leu Arg 
                325                 330                 335     


Asn Thr Pro Ser Ile Glu Pro Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Ser Gly Met Ile Asp Gly Trp Tyr Gly Phe 
        355                 360                 365             


His His Ser Asn Ser Glu Gly Thr Gly Met Ala Ala Asp Gln Lys Ser 
    370                 375                 380                 


Thr Gln Glu Ala Ile Asp Lys Ile Thr Asn Lys Val Asn Asn Ile Val 
385                 390                 395                 400 


Asp Lys Met Asn Arg Glu Phe Glu Val Val Asn His Glu Phe Ser Glu 
                405                 410                 415     


Val Glu Lys Arg Ile Asn Met Ile Asn Asp Lys Ile Asp Asp Gln Ile 
            420                 425                 430         


Glu Asp Leu Trp Ala Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Gln Lys Thr Leu Asp Glu His Asp Ser Asn Val Lys Asn Leu Phe Asp 
    450                 455                 460                 


Glu Val Arg Arg Arg Leu Ser Ala Asn Ala Ile Asp Thr Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Asp Ile Leu His Lys Cys Asp Asn Glu Cys Met Glu Thr Ile 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asn His Lys Glu Tyr Glu Glu Glu Ala Lys Leu 
            500                 505                 510         


Glu Arg Ser Lys Ile Asn Gly Val Lys Leu Glu Glu Asn Thr Thr Tyr 
        515                 520                 525             


Lys Ile Leu Ser Ile Tyr Ser Thr Val Ala Ala Ser Leu Cys Leu Ala 
    530                 535                 540                 


Ile Leu Ile Ala Gly Gly Leu Ile Leu Gly Met Gln Asn Gly Ser Cys 
545                 550                 555                 560 


Arg Cys Met Phe Cys Ile 
                565     


<210>  174
<211>  1840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding influenza A/Vietnam/1203/04 (HALo) virus HA

<400>  174
cggatgttgc ccagccggcg ccagcgagga ggctgggacc atgccggcca gcaaaagcag       60

gggttcaatc tgtcaaaatg gagaaaatag tgcttctttt tgcaatagtc agtcttgtta      120

aaagtgatca gatttgcatt ggttaccatg caaacaactc gacagagcag gttgacacaa      180

taatggaaaa gaacgttact gttacacatg cccaagacat actggaaaag aaacacaacg      240

ggaagctctg cgatctagat ggagtgaagc ctctaatttt gagagattgt agcgtagctg      300

gatggctcct cggaaaccca atgtgtgacg aattcatcaa tgtgccggaa tggtcttaca      360

tagtggagaa ggccaatcca gtcaatgacc tctgttaccc aggggatttc aatgactatg      420

aagaattgaa acacctattg agcagaataa accattttga gaaaattcag atcatcccca      480

aaagttcttg gtccagtcat gaagcctcat taggggtgag ctcagcatgt ccataccagg      540

gaaagtcctc ctttttcaga aatgtggtat ggcttatcaa aaagaacagt acatacccaa      600

caataaagag gagctacaat aataccaacc aagaagatct tttggtactg tgggggattc      660

accatcctaa tgatgcggca gagcagacaa agctctatca aaacccaacc acctatattt      720

ccgttgggac atcaacacta aaccagagat tggtaccaag aatagctact agatccaaag      780

taaacgggca aagtggaagg atggagttct tctggacaat tttaaagccg aatgatgcaa      840

tcaacttcga gagtaatgga aatttcattg ctccagaata tgcatacaaa attgtcaaga      900

aaggggactc aacaattatg aaaagtgaat tggaatatgg taactgcaac accaagtgtc      960

aaactccaat gggggcgata aactctagca tgccattcca caatatacac cctctcacca     1020

ttggggaatg ccccaaatat gtgaaatcaa acagattagt ccttgcgact gggctcagaa     1080

atagccctca gcgggagacg cggggattat ttggagctat agcaggtttt atagagggag     1140

gatggcaggg aatggtagat ggttggtatg ggtaccacca tagcaatgag caggggagtg     1200

ggtacgctgc agacaaagaa tccactcaaa aggcaataga tggagtcacc aataaggtca     1260

actcgatcat tgacaaaatg aacactcagt ttgaggccgt tggaagggaa tttaacaact     1320

tagaaaggag aatagagaat ttaaacaaga agatggaaga cgggttccta gatgtctgga     1380

cttataatgc tgaacttctg gttctcatgg aaaatgagag aactctagac tttcatgact     1440

caaatgtcaa gaacctttac gacaaggtcc gactacagct tagggataat gcaaaggagc     1500

tgggtaacgg ttgtttcgag ttctatcata aatgtgataa tgaatgtatg gaaagtgtaa     1560

gaaatggaac gtatgactac ccgcagtatt cagaagaagc gagactaaaa agagaggaaa     1620

taagtggagt aaaattggaa tcaataggaa tttaccaaat actgtcaatt tattctacag     1680

tggcgagttc cctagcactg gcaatcatgg tagctggtct atccttatgg atgtgctcca     1740

atgggtcgtt acaatgcaga atttgcattt aaatttgtga gttcagattg tagttaaaaa     1800

cacccttgtt tctactaata acccggcggc ccaaaatgcc                           1840


<210>  175
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  influenza A/Vietnam/1203/04 (HALo) virus HA

<400>  175

Met Glu Lys Ile Val Leu Leu Phe Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Lys His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Ala Asn Pro Val Asn Asp Leu Cys Tyr Pro Gly Asp Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu 
        115                 120                 125             


Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Ser His Glu Ala Ser 
    130                 135                 140                 


Leu Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Lys Ser Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Ser Thr Tyr Pro Thr Ile 
                165                 170                 175     


Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr Gln 
        195                 200                 205             


Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Leu Val Pro Arg Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr Gly 
        275                 280                 285             


Asn Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 
                325                 330                 335     


Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
            340                 345                 350         


Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His 
        355                 360                 365             


Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln 
    370                 375                 380                 


Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser Ile Ile Asp Lys 
385                 390                 395                 400 


Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe Asn Asn Leu Glu 
                405                 410                 415     


Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp 
            420                 425                 430         


Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg 
        435                 440                 445             


Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val 
    450                 455                 460                 


Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe 
465                 470                 475                 480 


Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg Asn 
                485                 490                 495     


Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala Arg Leu Lys Arg 
            500                 505                 510         


Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Ile Gly Ile Tyr Gln Ile 
        515                 520                 525             


Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala Leu Ala Ile Met 
    530                 535                 540                 


Val Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly Ser Leu Gln Cys 
545                 550                 555                 560 


Arg Ile Cys Ile Ile Cys Glu Phe Arg Leu Leu Lys Thr Pro Leu Phe 
                565                 570                 575     


Leu Leu Ile Thr Arg Arg Pro Lys Met 
            580                 585 


<210>  176
<211>  1745
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding influenza A/northern 
       shoveler/Netherlands/18/99 virus HA

<400>  176
aaagcagggg ttctattaag aaatcaaaat gaagaaagca ctgctatttg cagctatttt       60

cctttatgca aaggcagatg aaatctgtat cggctactta agcaacaact caacagacaa      120

agttgacaca ataatcgaga acaatgtcac agtgactagc tcagtggaac tagtcgaaac      180

agaacacact gggtcattct gctcaatcaa tggaaaacaa ccgataagtc ttggagactg      240

ctcttttgct gggtggatat taggtaatcc catgtgtgat gatctaattg gtaagacttc      300

atggtcctac attgtggaga agcccaaccc aacaaatgga atttgttacc ctggaacttt      360

ggaggatgaa gaagaactga gactgaaatt cagtggagtc ctggaattca gcaagttcga      420

agcattcaca tcaaatggat ggggtgctgt gaattcggga gcaggagtga ctgctgcatg      480

caaattcgga agctccaatt ctttcttccg aaacatggta tggcttatac atcaatcagg      540

aacatatcct gtaataaaga ggacttttaa caataccaaa ggaagagatg tgttgatcgt      600

ttggggaatt catcaccctg ccacactgaa agagcaccaa gacctataca agaaagacag      660

ttcctatgta gcagtgggtt cagaaactta caacagaaga ttcaccccag aaatcagcac      720

taggcccaaa gtcaatggac aggctggacg gatgacattt tattggacaa tggtcaaacc      780

aggagagtca ataacatttg agtctaatgg tgcattcttg gctcctagat atgcttttga      840

gattgtctct gttggaaatg ggaaattatt cagaagcgaa ctgagtattg aatcatgctc      900

taccaaatgc caaacagaag taggagggat taatacaaac aaaagtttcc acagtgttca      960

taggaacact attggagact gtcccaaata tgtgaatgtc aaatccctaa agcttgccac     1020

aggacttaga aatgttccag caatagcatc aagaggattg tttggagcaa tagccggatt     1080

tatagaaggt gggtggccag ggcttatcaa tggatggtac ggttttcaac acagaaatga     1140

ggaaggaaca ggcatagcag cagacaggga gtcaactcaa aaggcagtag accagataac     1200

atccaaagta aacaacatcg tcgacagaat gaatacaaat ttcgagtctg tgcaacacga     1260

attcagtgaa atagaggaga ggataaacca attgtcgaaa cacgtagatg attctgtggt     1320

tgacatctgg tcatataacg cacaactcct cgtttggctt gaaaatgaga aaactctgga     1380

tctccacgat tccaatgtta ggaatcttca tgagaaagtc agaaggatgc taaaggacaa     1440

tgccaaagat gagggaaatg gatgcttcac cttttaccac aagtgtgaca acgaatgcat     1500

cgaaaaggtt agaaacggaa catatgatca caaagaattc gaagaagaat caagaatcaa     1560

tcgccaggag attgagggag tgagattaga ttctagtggg aatgtgtata aaatactgtc     1620

aatttacagc tgcatcgcaa gcagtcttgt attagcagca ctcatcatgg gtttcatcct     1680

atgggcgtgc agcaatggat catgtagatg taccatttgc atttagaatt gtggcaaaaa     1740

caccc                                                                 1745


<210>  177
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of influenza A/northern 
       shoveler/Netherlands/18/99 virus HA

<400>  177

Met Lys Lys Ala Leu Leu Phe Ala Ala Ile Phe Leu Tyr Ala Lys Ala 
1               5                   10                  15      


Asp Glu Ile Cys Ile Gly Tyr Leu Ser Asn Asn Ser Thr Asp Lys Val 
            20                  25                  30          


Asp Thr Ile Ile Glu Asn Asn Val Thr Val Thr Ser Ser Val Glu Leu 
        35                  40                  45              


Val Glu Thr Glu His Thr Gly Ser Phe Cys Ser Ile Asn Gly Lys Gln 
    50                  55                  60                  


Pro Ile Ser Leu Gly Asp Cys Ser Phe Ala Gly Trp Ile Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Asp Leu Ile Gly Lys Thr Ser Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Pro Asn Pro Thr Asn Gly Ile Cys Tyr Pro Gly Thr Leu Glu 
            100                 105                 110         


Asp Glu Glu Glu Leu Arg Leu Lys Phe Ser Gly Val Leu Glu Phe Ser 
        115                 120                 125             


Lys Phe Glu Ala Phe Thr Ser Asn Gly Trp Gly Ala Val Asn Ser Gly 
    130                 135                 140                 


Ala Gly Val Thr Ala Ala Cys Lys Phe Gly Ser Ser Asn Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Met Val Trp Leu Ile His Gln Ser Gly Thr Tyr Pro Val Ile 
                165                 170                 175     


Lys Arg Thr Phe Asn Asn Thr Lys Gly Arg Asp Val Leu Ile Val Trp 
            180                 185                 190         


Gly Ile His His Pro Ala Thr Leu Lys Glu His Gln Asp Leu Tyr Lys 
        195                 200                 205             


Lys Asp Ser Ser Tyr Val Ala Val Gly Ser Glu Thr Tyr Asn Arg Arg 
    210                 215                 220                 


Phe Thr Pro Glu Ile Ser Thr Arg Pro Lys Val Asn Gly Gln Ala Gly 
225                 230                 235                 240 


Arg Met Thr Phe Tyr Trp Thr Met Val Lys Pro Gly Glu Ser Ile Thr 
                245                 250                 255     


Phe Glu Ser Asn Gly Ala Phe Leu Ala Pro Arg Tyr Ala Phe Glu Ile 
            260                 265                 270         


Val Ser Val Gly Asn Gly Lys Leu Phe Arg Ser Glu Leu Ser Ile Glu 
        275                 280                 285             


Ser Cys Ser Thr Lys Cys Gln Thr Glu Val Gly Gly Ile Asn Thr Asn 
    290                 295                 300                 


Lys Ser Phe His Ser Val His Arg Asn Thr Ile Gly Asp Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Asn Val Lys Ser Leu Lys Leu Ala Thr Gly Leu Arg Asn Val 
                325                 330                 335     


Pro Ala Ile Ala Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
            340                 345                 350         


Glu Gly Gly Trp Pro Gly Leu Ile Asn Gly Trp Tyr Gly Phe Gln His 
        355                 360                 365             


Arg Asn Glu Glu Gly Thr Gly Ile Ala Ala Asp Arg Glu Ser Thr Gln 
    370                 375                 380                 


Lys Ala Val Asp Gln Ile Thr Ser Lys Val Asn Asn Ile Val Asp Arg 
385                 390                 395                 400 


Met Asn Thr Asn Phe Glu Ser Val Gln His Glu Phe Ser Glu Ile Glu 
                405                 410                 415     


Glu Arg Ile Asn Gln Leu Ser Lys His Val Asp Asp Ser Val Val Asp 
            420                 425                 430         


Ile Trp Ser Tyr Asn Ala Gln Leu Leu Val Trp Leu Glu Asn Glu Lys 
        435                 440                 445             


Thr Leu Asp Leu His Asp Ser Asn Val Arg Asn Leu His Glu Lys Val 
    450                 455                 460                 


Arg Arg Met Leu Lys Asp Asn Ala Lys Asp Glu Gly Asn Gly Cys Phe 
465                 470                 475                 480 


Thr Phe Tyr His Lys Cys Asp Asn Glu Cys Ile Glu Lys Val Arg Asn 
                485                 490                 495     


Gly Thr Tyr Asp His Lys Glu Phe Glu Glu Glu Ser Arg Ile Asn Arg 
            500                 505                 510         


Gln Glu Ile Glu Gly Val Arg Leu Asp Ser Ser Gly Asn Val Tyr Lys 
        515                 520                 525             


Ile Leu Ser Ile Tyr Ser Cys Ile Ala Ser Ser Leu Val Leu Ala Ala 
    530                 535                 540                 


Leu Ile Met Gly Phe Ile Leu Trp Ala Cys Ser Asn Gly Ser Cys Arg 
545                 550                 555                 560 


Cys Thr Ile Cys Ile 
                565 


<210>  178
<211>  1712
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding A_mallard_interior Alaska_7MP0167_2007 virus HA

<400>  178
ggtcacaatg gaaaaattca tcattttgag cactgtcctg gcagtaagct ttgcatatga       60

caaaatttgc attggatatc aaacaaacaa ctcgactgag acagtaaaca cactaatcga      120

gcaaaacgtt ccggtgacac aggtggaaga actcgtgcat ggtgggatcg atccggtcct      180

atgtggaacg gagctagggt caccattagt gcttgatgac tgttcactcg aaggtctcat      240

tctaggcaat cccaaatgtg atctttatct gaatggcagg gaatggtcat acatagtaga      300

gaggcccaaa gaaatggaag gagtttgcta cccaggatca attgaaaatc aagaggagtt      360

gagatctctg ttttcttcca tcaagaagta tgaaagagtg aagatgtttg atttcaccaa      420

atggaatgtc acgtacactg gaaccagcaa ggcctgcaac aatacatcaa accaaggctc      480

attctatagg agcatgagat ggttaacctt aaaatcagga caattcccag tccagacaga      540

tgagtacaag aacaccagag attcggacat tgtcttcacc tgggccatcc atcacccacc      600

aacatctgat gaacagataa agttatacaa aaatccggat accctctcct cagtcaccac      660

tgatgaaatc aataggagtt tcaagcctaa cataggacca aggccattag tgagaggaca      720

acaggggaga atggattact actgggctgt cctcaaacct ggacaaactg tcaaaataca      780

gaccaatggt aatcttattg cacctgaata tggtcactta attacaggga aatcacatgg      840

caggatactc aagaataact tgcccatagg acagtgtgtg actgagtgcc agttgaatga      900

aggggtgatg aatacaagta aacctttcca gaacactagt aagcactata ttgggaaatg      960

tcccaaatac ataccatcag gaagcctgaa attggcgata gggctcagaa atgttccaca     1020

agttcagaac agaggactat ttggagcaaa agcaggtttc atagagggcg gatggccagg     1080

actagtggct ggttggtatg gatttcagca tcaaaatgca gaggggacag gcatagccgc     1140

agacagagac agcactcaga aggcaataga caatatgcaa aacaaactca acaatgtcat     1200

tgacaaaatg aacaaacaat ttgaagtggt gaatcatgag ttttcagaag tggaaagcag     1260

aataaacatg attaattccc aaattgatga tcaaataact gacatatggg catacaatgc     1320

tgaactgctt gtcctattgg aaaatcagaa gacattagat gagcatgatg ctaatgtaag     1380

aaacttacac gatagagtca gaagagtcct aagagaaaat gcaattgata caggagatgg     1440

ttgctttgaa attctgcata aatgtgacaa caattgcatg gacacaatca gaaatgggac     1500

atacaatcac aaggagtatg aggaagaaag caaaatcgaa cgacagaaaa ttaatggtgt     1560

caaacttgag gagaattcta catataaaat tctgagcatc tacagcagtg ttgcctcaag     1620

cttagttcta ctgctcatga ttattggggg tttcattttc gggtgtcaaa atggaaatgt     1680

tcgttgtact ttctgtattt aattaaaaac ac                                   1712


<210>  179
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A_mallard_interior Alaska_7MP0167_2007 virus HA

<400>  179

Met Glu Lys Phe Ile Ile Leu Ser Thr Val Leu Ala Val Ser Phe Ala 
1               5                   10                  15      


Tyr Asp Lys Ile Cys Ile Gly Tyr Gln Thr Asn Asn Ser Thr Glu Thr 
            20                  25                  30          


Val Asn Thr Leu Ile Glu Gln Asn Val Pro Val Thr Gln Val Glu Glu 
        35                  40                  45              


Leu Val His Gly Gly Ile Asp Pro Val Leu Cys Gly Thr Glu Leu Gly 
    50                  55                  60                  


Ser Pro Leu Val Leu Asp Asp Cys Ser Leu Glu Gly Leu Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Lys Cys Asp Leu Tyr Leu Asn Gly Arg Glu Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Arg Pro Lys Glu Met Glu Gly Val Cys Tyr Pro Gly Ser Ile 
            100                 105                 110         


Glu Asn Gln Glu Glu Leu Arg Ser Leu Phe Ser Ser Ile Lys Lys Tyr 
        115                 120                 125             


Glu Arg Val Lys Met Phe Asp Phe Thr Lys Trp Asn Val Thr Tyr Thr 
    130                 135                 140                 


Gly Thr Ser Lys Ala Cys Asn Asn Thr Ser Asn Gln Gly Ser Phe Tyr 
145                 150                 155                 160 


Arg Ser Met Arg Trp Leu Thr Leu Lys Ser Gly Gln Phe Pro Val Gln 
                165                 170                 175     


Thr Asp Glu Tyr Lys Asn Thr Arg Asp Ser Asp Ile Val Phe Thr Trp 
            180                 185                 190         


Ala Ile His His Pro Pro Thr Ser Asp Glu Gln Ile Lys Leu Tyr Lys 
        195                 200                 205             


Asn Pro Asp Thr Leu Ser Ser Val Thr Thr Asp Glu Ile Asn Arg Ser 
    210                 215                 220                 


Phe Lys Pro Asn Ile Gly Pro Arg Pro Leu Val Arg Gly Gln Gln Gly 
225                 230                 235                 240 


Arg Met Asp Tyr Tyr Trp Ala Val Leu Lys Pro Gly Gln Thr Val Lys 
                245                 250                 255     


Ile Gln Thr Asn Gly Asn Leu Ile Ala Pro Glu Tyr Gly His Leu Ile 
            260                 265                 270         


Thr Gly Lys Ser His Gly Arg Ile Leu Lys Asn Asn Leu Pro Ile Gly 
        275                 280                 285             


Gln Cys Val Thr Glu Cys Gln Leu Asn Glu Gly Val Met Asn Thr Ser 
    290                 295                 300                 


Lys Pro Phe Gln Asn Thr Ser Lys His Tyr Ile Gly Lys Cys Pro Lys 
305                 310                 315                 320 


Tyr Ile Pro Ser Gly Ser Leu Lys Leu Ala Ile Gly Leu Arg Asn Val 
                325                 330                 335     


Pro Gln Val Gln Asn Arg Gly Leu Phe Gly Ala Lys Ala Gly Phe Ile 
            340                 345                 350         


Glu Gly Gly Trp Pro Gly Leu Val Ala Gly Trp Tyr Gly Phe Gln His 
        355                 360                 365             


Gln Asn Ala Glu Gly Thr Gly Ile Ala Ala Asp Arg Asp Ser Thr Gln 
    370                 375                 380                 


Lys Ala Ile Asp Asn Met Gln Asn Lys Leu Asn Asn Val Ile Asp Lys 
385                 390                 395                 400 


Met Asn Lys Gln Phe Glu Val Val Asn His Glu Phe Ser Glu Val Glu 
                405                 410                 415     


Ser Arg Ile Asn Met Ile Asn Ser Gln Ile Asp Asp Gln Ile Thr Asp 
            420                 425                 430         


Ile Trp Ala Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Gln Lys 
        435                 440                 445             


Thr Leu Asp Glu His Asp Ala Asn Val Arg Asn Leu His Asp Arg Val 
    450                 455                 460                 


Arg Arg Val Leu Arg Glu Asn Ala Ile Asp Thr Gly Asp Gly Cys Phe 
465                 470                 475                 480 


Glu Ile Leu His Lys Cys Asp Asn Asn Cys Met Asp Thr Ile Arg Asn 
                485                 490                 495     


Gly Thr Tyr Asn His Lys Glu Tyr Glu Glu Glu Ser Lys Ile Glu Arg 
            500                 505                 510         


Gln Lys Ile Asn Gly Val Lys Leu Glu Glu Asn Ser Thr Tyr Lys Ile 
        515                 520                 525             


Leu Ser Ile Tyr Ser Ser Val Ala Ser Ser Leu Val Leu Leu Leu Met 
    530                 535                 540                 


Ile Ile Gly Gly Phe Ile Phe Gly Cys Gln Asn Gly Asn Val Arg Cys 
545                 550                 555                 560 


Thr Phe Cys Ile 
                


<210>  180
<211>  1775
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding influenza A/Puerto Rico/8/34 virus HA

<400>  180
agcaaaagca ggggaaaata aaaacaacca aaatgaaggc aaacctactg gtcctgttaa       60

gtgcacttgc agctgcagat gcagacacaa tatgtatagg ctaccatgcg aacaattcaa      120

ccgacactgt tgacacagta ctcgagaaga atgtgacagt gacacactct gttaacctgc      180

tcgaagacag ccacaacgga aaactatgta gattaaaagg aatagcccca ctacaattgg      240

ggaaatgtaa catcgccgga tggctcttgg gaaacccaga atgcgaccca ctgcttccag      300

tgagatcatg gtcctacatt gtagaaacac caaactctga gaatggaata tgttatccag      360

gagatttcat cgactatgag gagctgaggg agcaattgag ctcagtgtca tcattcgaaa      420

gattcgaaat atttcccaaa gaaagctcat ggcccaacca caacacaaac ggagtaacgg      480

cagcatgctc ccatgagggg aaaagcagtt tttacagaaa tttgctatgg ctgacggaga      540

aggagggctc atacccaaag ctgaaaaatt cttatgtgaa caaaaaaggg aaagaagtcc      600

ttgtactgtg gggtattcat cacccgccta acagtaagga acaacagaat atctatcaga      660

atgaaaatgc ttatgtctct gtagtgactt caaattataa caggagattt accccggaaa      720

tagcagaaag acccaaagta agagatcaag ctgggaggat gaactattac tggaccttgc      780

taaaacccgg agacacaata atatttgagg caaatggaaa tctaatagca ccaatgtatg      840

ctttcgcact gagtagaggc tttgggtccg gcatcatcac ctcaaacgca tcaatgcatg      900

agtgtaacac gaagtgtcaa acacccctgg gagctataaa cagcagtctc ccttaccaga      960

atatacaccc agtcacaata ggagagtgcc caaaatacgt caggagtgcc aaattgagga     1020

tggttacagg actaaggaac actccgtcca ttcaatccag aggtctattt ggagccattg     1080

ccggttttat tgaaggggga tggactggaa tgatagatgg atggtatggt tatcatcatc     1140

agaatgaaca gggatcaggc tatgcagcgg atcaaaaaag cacacaaaat gccattaacg     1200

ggattacaaa caaggtgaac actgttatcg agaaaatgaa cattcaattc acagctgtgg     1260

gtaaagaatt caacaaatta gaaaaaagga tggaaaattt aaataaaaaa gttgatgatg     1320

gatttctgga catttggaca tataatgcag aattgttagt tctactggaa aatgaaagga     1380

ctctggattt ccatgactca aatgtgaaga atctgtatga gaaagtaaaa agccaattaa     1440

agaataatgc caaagaaatc ggaaatggat gttttgagtt ctaccacaag tgtgacaatg     1500

aatgcatgga aagtgtaaga aatgggactt atgattatcc caaatattca gaagagtcaa     1560

agttgaacag ggaaaaggta gatggagtga aattggaatc aatggggatc tatcagattc     1620

tggcgatcta ctcaactgtc gccagttcac tggtgctttt ggtctccctg ggggcaatca     1680

gtttctggat gtgttctaat ggatctttgc agtgcagaat atgcatctga gattagaatt     1740

tcagaaatat gaggaaaaac acccttgttt ctact                                1775


<210>  181
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of influenza A/Puerto Rico/8/34 virus HA

<400>  181

Met Lys Ala Asn Leu Leu Val Leu Leu Ser Ala Leu Ala Ala Ala Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Asp Pro Leu Leu Pro Val Arg Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Ser Glu Asn Gly Ile Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Asn 
    130                 135                 140                 


Thr Asn Gly Val Thr Ala Ala Cys Ser His Glu Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Glu Gly Ser Tyr Pro Lys 
                165                 170                 175     


Leu Lys Asn Ser Tyr Val Asn Lys Lys Gly Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Ile His His Pro Pro Asn Ser Lys Glu Gln Gln Asn Ile Tyr 
        195                 200                 205             


Gln Asn Glu Asn Ala Tyr Val Ser Val Val Thr Ser Asn Tyr Asn Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Arg Asp Gln Ala 
225                 230                 235                 240 


Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Lys Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Met Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser Met 
        275                 280                 285             


His Glu Cys Asn Thr Lys Cys Gln Thr Pro Leu Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Tyr Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Thr Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Thr Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Ile Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Val Asp Gly Val Lys Leu Glu Ser Met Gly Ile Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


<210>  182
<211>  1879
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding influenza B/Yamagata/16/88 virus HA

<400>  182
agcagaagca gagcattttc taatatccac aaaatgaagg caataattgt actactcatg       60

gtagtaacat ccaacgcaga tcgaatctgc actgggataa catcttcaaa ctcacctcat      120

gtggtcaaaa cagctactca aggggaagtt aatgtgactg gtgtgatacc actgacaaca      180

acaccaacaa aatctcattt tgcaaatctc aaaggaacaa agaccagagg gaaactatgc      240

ccaaactgtc tcaactgcac agatctggat gtggccttgg gcagaccaat gtgtatgggg      300

accatacctt cggcaaaagc ttcaatactc cacgaagtca gacctgttac atccgggtgc      360

tttcctataa tgcacgacag aacaaaaatc agacagctac ccaatcttct cagaggatat      420

gaaaatatca gattatcaac ccataacgtt atcaacgcag aaagggcacc aggaggaccc      480

tacagacttg gaacctcaga atcttgccct aacgttacca gtagaaacgg attcttcgca      540

acaatggctt gggctgtccc aagggacaac aaaacagcaa cgaatccact aacagtagaa      600

gtaccataca tttgcacaaa aggagaagac caaattactg tttgggggtt ccattctgat      660

aacaaaaacc aaatgaaaaa cctctatgga gactcaaatc ctcaaaagtt cacctcatct      720

gccaatggag taaccacaca ttatgtttct cagattggtg acttcccaaa tcaaacagaa      780

gacggagggc taccacaaag cggcagaatt gttgttgatt acatggtgca aaaacctggg      840

aaaacaggaa caattgtcta tcaaagaggt gttttgttgc ctcaaaaggt gtggtgcgca      900

agtggcagga gcaaggtaat aaaagggtcc ttgcctttaa ttggtgaagc agattgcctt      960

cacgaaaaat acggtggatt aaacaaaagc aagccttact acacaggaga acatgcaaaa     1020

gccataggaa attgcccaat atgggtgaaa acacctttga agcttgccaa tggaaccaaa     1080

tatagacctc ctgcaaaact attaaaggaa aggggtttct tcggagctat tgctggtttc     1140

ttagagggag gatgggaagg aatgattgca ggttggcacg gatacacatc tcatggagca     1200

catggagtgg cagtggcagc agaccttaag agcacgcaag aagccataaa caagataaca     1260

aaaaatctca attctttgag tgagctagaa gtaaagaatc ttcaaagact aagtggtgcc     1320

atggatgaac tccacaacga aatactcgag ctggatgaga aagtggatga tctcagagct     1380

gacacaataa gctcgcaaat agagcttgca gtcttgcttt ccaacgaagg aataataaac     1440

agtgaagatg agcatctatt ggcacttgag agaaaactaa agaaaatgct gggtccctct     1500

gctgtagaca tagggaatgg atgcttcgaa accaaacaca agtgcaacca gacctgctta     1560

gacaggatag ctgctggcac ctttaatgca ggagaatttt ctcttcccac ttttgattca     1620

ctgaatatta ctgctgcatc tttaaatgat gatggattgg ataatcatac tatactgctc     1680

tactactcaa ctgctgcttc tagtttggcc gtaacattga tgatagctat ttttattgtt     1740

tatatggtct ccagagacaa tgtttcttgc tccatctgtc tataaggaaa attaagccct     1800

gtattttcct ttattgtagt gcttgtttgc ttgttaccat tacaaagaaa cgttattgaa     1860

aaatgctctt gttactact                                                  1879


<210>  183
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of influenza B/Yamagata/16/88 virus HA

<400>  183

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Met Gly Thr Ile Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Asn Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Arg 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Glu Ser Cys Pro Asn 
145                 150                 155                 160 


Val Thr Ser Arg Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Arg Asp Asn Lys Thr Ala Thr Asn Pro Leu Thr Val Glu Val Pro Tyr 
            180                 185                 190         


Ile Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser 
        195                 200                 205             


Asp Asn Lys Asn Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn Pro Gln 
    210                 215                 220                 


Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln 
225                 230                 235                 240 


Ile Gly Asp Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser 
                245                 250                 255     


Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr Gly 
            260                 265                 270         


Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp Cys 
        275                 280                 285             


Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly 
    290                 295                 300                 


Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys 
305                 310                 315                 320 


Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile 
                325                 330                 335     


Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro 
            340                 345                 350         


Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly 
        355                 360                 365             


Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr 
    370                 375                 380                 


Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser 
385                 390                 395                 400 


Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser 
                405                 410                 415     


Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu 
            420                 425                 430         


Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg 
        435                 440                 445             


Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn 
    450                 455                 460                 


Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg 
465                 470                 475                 480 


Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn Gly 
                485                 490                 495     


Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile 
            500                 505                 510         


Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp 
        515                 520                 525             


Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn 
    530                 535                 540                 


His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val 
545                 550                 555                 560 


Thr Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp Asn 
                565                 570                 575     


Val Ser Cys Ser Ile Cys Leu 
            580             


<210>  184
<211>  1876
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding mH5/B chimeric HA for rescue in 
       B/Yamagata/16/88

<400>  184
agcagaagca gagcattttc taatatccac aaaatgaagg caataattgt actactcatg       60

gtagtaacat ccaacgcaga tcgaatctgc actgggataa catcttcaaa ctcacctcat      120

gtggtcaaaa cagctactca aggggaagtt aatgtgactg gtgtgatacc actgacaaca      180

acaccaacaa aatctcattt tgcaaatctc aaaggaacaa agaccagagg gaaactatgc      240

ccaaactgtc tcaactgcac agatctggat gtggccttgg gcagaccaat gtgtatgggg      300

ttcatacctt cggcaaaagc ttcaatactc cacgaagtca gacctgttac atccgggtgc      360

tttcctataa tgcacgacag aacaaaaatc agacagctac ccaatcttct cagaggatat      420

gaaaaaatcc agttatcaac caaaaacgtt atcaacgcag aacatgcacc aggaggaccc      480

tacagacttg gaacctcaaa atcttgccca taccagggaa agtcctcctt cttcgcaaca      540

atggcttggg ctgtcccaaa aaagaacagt acatacacga atccactaac agtagaagta      600

ccatacattt gcacaaaagg agaagaccaa attactgttt gggggttcca ttctgataat      660

gatgcggcaa tgcagacact ctatggagac tcaaatcctc aaaagttcac ctcatctgcc      720

aatggagtaa ccacacatta tgtttctcag attggtgact tcccaaatca aacagaagac      780

ggagggctac cacaaagcgg cagaattgtt gttgattaca tggtgcaaaa acctgggaaa      840

acaggaacaa ttgtctatca aagaggtgtt ttgttgcctc aaaaggtgtg gtgcgcaagt      900

ggcaggagca aggtaataaa agggtccttg cctttaattg gtgaagcaga ttgccttcac      960

gaaaaatacg gtggattaaa caaaagcaag ccttactaca caggagaaca tgcaaaagcc     1020

ataggaaatt gcccaatatg ggtgaaaaca cctttgaagc ttgccaatgg aaccaaatat     1080

agacctcctg caaaactatt aaaggaaagg ggtttcttcg gagctattgc tggtttctta     1140

gagggaggat gggaaggaat gattgcaggt tggcacggat acacatctca tggagcacat     1200

ggagtggcag tggcagcaga ccttaagagc acgcaagaag ccataaacaa gataacaaaa     1260

aatctcaatt ctttgagtga gctagaagta aagaatcttc aaagactaag tggtgccatg     1320

gatgaactcc acaacgaaat actcgagctg gatgagaaag tggatgatct cagagctgac     1380

acaataagct cgcaaataga gcttgcagtc ttgctttcca acgaaggaat aataaacagt     1440

gaagatgagc atctattggc acttgagaga aaactaaaga aaatgctggg tccctctgct     1500

gtagacatag ggaatggatg cttcgaaacc aaacacaagt gcaaccagac ctgcttagac     1560

aggatagctg ctggcacctt taatgcagga gaattttctc ttcccacttt tgattcactg     1620

aatattactg ctgcatcttt aaatgatgat ggattggata atcatactat actgctctac     1680

tactcaactg ctgcttctag tttggccgta acattgatga tagctatttt tattgtttat     1740

atggtctcca gagacaatgt ttcttgctcc atctgtctat aaggaaaatt aagccctgta     1800

ttttccttta ttgtagtgct tgtttgcttg ttaccattac aaagaaacgt tattgaaaaa     1860

tgctcttgtt actact                                                     1876


<210>  185
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mH5/B chimeric HA for rescue in B/Yamagata/16/88

<400>  185

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Met Gly Phe Ile Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Lys Ile Gln Leu Ser Thr Lys Asn Val Ile Asn Ala Glu His 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Lys Ser Cys Pro Tyr 
145                 150                 155                 160 


Gln Gly Lys Ser Ser Phe Phe Ala Thr Met Ala Trp Ala Val Pro Lys 
                165                 170                 175     


Lys Asn Ser Thr Tyr Thr Asn Pro Leu Thr Val Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Asp Ala Ala Met Gln Thr Leu Tyr Gly Asp Ser Asn Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Asp Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn His 
    530                 535                 540                 


Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val Thr 
545                 550                 555                 560 


Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp Asn Val 
                565                 570                 575     


Ser Cys Ser Ile Cys Leu 
            580         


<210>  186
<211>  1882
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding mH8/B chimeric HA for rescue in 
       B/Yamagata/16/88

<400>  186
agcagaagca gagcattttc taatatccac aaaatgaagg caataattgt actactcatg       60

gtagtaacat ccaacgcaga tcgaatctgc actgggataa catcttcaaa ctcacctcat      120

gtggtcaaaa cagctactca aggggaagtt aatgtgactg gtgtgatacc actgacaaca      180

acaccaacaa aatctcattt tgcaaatctc aaaggaacaa agaccagagg gaaactatgc      240

ccaaactgtc tcaactgcac agatctggat gtggccttgg gcagaccaat gtgtatgggg      300

cacatacctt cggcaaaagc ttcaatactc cacgaagtca gacctgttac atccgggtgc      360

tttcctataa tgcacgacag aacaaaaatc agacagctac ccaatcttct cagaggatat      420

gaaaggatca gattatcaac ctacaacgtt atcaacgcag aaaccgcacc aggaggaccc      480

tacagacttg gaacctcaaa atcttgcaat gcttcaacag gaggccaatc tttcttcgca      540

acaatggctt gggctgtccc aaaaaagaaa gcagacacct atacgaatcc actaacagta      600

gaagtaccat acatttgcac aaaaggagaa gaccaaatta ctgtttgggg gttccattct      660

gatgcagatg caaaaatgca aacactctat ggagactcaa atcctcaaaa gttcacctca      720

tctgccaatg gagtaaccac acattatgtt tctcagattg gtgacttccc aaatcaaaca      780

gaagacggag ggctaccaca aagcggcaga attgttgttg attacatggt gcaaaaacct      840

gggaaaacag gaacaattgt ctatcaaaga ggtgttttgt tgcctcaaaa ggtgtggtgc      900

gcaagtggca ggagcaaggt aataaaaggg tccttgcctt taattggtga agcagattgc      960

cttcacgaaa aatacggtgg attaaacaaa agcaagcctt actacacagg agaacatgca     1020

aaagccatag gaaattgccc aatatgggtg aaaacacctt tgaagcttgc caatggaacc     1080

aaatatagac ctcctgcaaa actattaaag gaaaggggtt tcttcggagc tattgctggt     1140

ttcttagagg gaggatggga aggaatgatt gcaggttggc acggatacac atctcatgga     1200

gcacatggag tggcagtggc agcagacctt aagagcacgc aagaagccat aaacaagata     1260

acaaaaaatc tcaattcttt gagtgagcta gaagtaaaga atcttcaaag actaagtggt     1320

gccatggatg aactccacaa cgaaatactc gagctggatg agaaagtgga tgatctcaga     1380

gctgacacaa taagctcgca aatagagctt gcagtcttgc tttccaacga aggaataata     1440

aacagtgaag atgagcatct attggcactt gagagaaaac taaagaaaat gctgggtccc     1500

tctgctgtag acatagggaa tggatgcttc gaaaccaaac acaagtgcaa ccagacctgc     1560

ttagacagga tagctgctgg cacctttaat gcaggagaat tttctcttcc cacttttgat     1620

tcactgaata ttactgctgc atctttaaat gatgatggat tggataatca tactatactg     1680

ctctactact caactgctgc ttctagtttg gccgtaacat tgatgatagc tatttttatt     1740

gtttatatgg tctccagaga caatgtttct tgctccatct gtctataagg aaaattaagc     1800

cctgtatttt cctttattgt agtgcttgtt tgcttgttac cattacaaag aaacgttatt     1860

gaaaaatgct cttgttacta ct                                              1882


<210>  187
<211>  584
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mH8/B chimeric HA for rescue in B/Yamagata/16/88

<400>  187

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Met Gly His Ile Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Arg Ile Arg Leu Ser Thr Tyr Asn Val Ile Asn Ala Glu Thr 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Lys Ser Cys Asn Ala 
145                 150                 155                 160 


Ser Thr Gly Gly Gln Ser Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Lys Lys Ala Asp Thr Tyr Thr Asn Pro Leu Thr Val Glu Val Pro 
            180                 185                 190         


Tyr Ile Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His 
        195                 200                 205             


Ser Asp Ala Asp Ala Lys Met Gln Thr Leu Tyr Gly Asp Ser Asn Pro 
    210                 215                 220                 


Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser 
225                 230                 235                 240 


Gln Ile Gly Asp Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln 
                245                 250                 255     


Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr 
            260                 265                 270         


Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp 
        275                 280                 285             


Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile 
    290                 295                 300                 


Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser 
305                 310                 315                 320 


Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro 
                325                 330                 335     


Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg 
            340                 345                 350         


Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala 
        355                 360                 365             


Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly 
    370                 375                 380                 


Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys 
385                 390                 395                 400 


Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu 
                405                 410                 415     


Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp 
            420                 425                 430         


Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu 
        435                 440                 445             


Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser 
    450                 455                 460                 


Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 
465                 470                 475                 480 


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn 
                485                 490                 495     


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
            500                 505                 510         


Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe 
        515                 520                 525             


Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp 
    530                 535                 540                 


Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala 
545                 550                 555                 560 


Val Thr Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp 
                565                 570                 575     


Asn Val Ser Cys Ser Ile Cys Leu 
            580                 


<210>  188
<211>  1972
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding mH11/B chimeric HA for rescue in 
       B/Yamagata/16/88

<400>  188
agcagaagca gagcattttc taatatccac aaaatgaagg caataattgt actactcatg       60

gtagtaacat ccaacgcaga tcgaatctgc actgggataa catcttcaaa ctcacctcat      120

gtggtcaaaa cagctactca aggggaagtt aatgtgactg gtgtgatacc actgacaaca      180

acaccaacaa aatctcattt tgcaaatctc aaaggaacaa agaccagagg gaaactatgc      240

ccaaactgtc tcaactgcac agatctggat gtggccttgg gcagaccaat gtgtatgggg      300

ctaatacctt cggcaaaagc ttcaatactc cacgaagtca gacctgttac atccgggtgc      360

tttcctataa tgcacgacag aacaaaaatc agacagctac ccaatcttct cagaggatat      420

gaaaagatcg aattatcaac ctcaaacgtt atcaacgcag aagtggcacc aggaggaccc      480

tacagacttg gaacctcaga atcttgccct ttcggaagct ccaattcttt cttcgcaaca      540

atggcttggg ctgtcccaca tcaatcagga acatatacga atccactaac agtagaagta      600

ccatacattt gcacaaaagg agaagaccaa attactgttt gggggttcca ttctgatacc      660

acactgaaaa tgcaccaact ctatggagac tcaaatcctc aaaagttcac ctcatctgcc      720

aatggagtaa ccacacatta tgtttctcag attggtgact tcccaaatca aacagaagac      780

gaagggctac cacaaagcgg cagaattgtt gttgattaca tggtgcaaaa acctgggaaa      840

acaggaacaa ttgtctatca aagaggtgtt ttgttgcctc aaaaggtgtg gtgcgcaagt      900

ggcaggagca aggtaataaa agggtccttg cctttaattg gtgaagcaga ttgccttcac      960

gaaaaatacg gtggattaaa caaaagcaag ccttactaca caggagaaca tgcaaaagcc     1020

ataggaaatt gcccaatatg ggtgaaaaca cctttgaagc ttgccaatgg aaccaaatat     1080

agacctcctg caaaactatt aaaggaaagg ggtttcttcg gagctattgc tggtttctta     1140

gagggaggat gggaaggaat gattgcaggt tggcacggat acacatctca tggagcacat     1200

ggagtggcag tggcagcaga ccttaagagc acgcaagaag ccataaacaa gataacaaaa     1260

aatctcaatt ctttgagtga gctagaagta aagaatcttc aaagactaag tggtgccatg     1320

gatgaactcc acaacgaaat actcgagctg gatgagaaag tggatgatct cagagctgac     1380

acaataagct cgcaaataga gcttgcagtc ttgctttcca acgaaggaat aataaacagt     1440

gaagatgagc atctattggc acttgagaga aaactaaaga aaatgctggg tccctctgct     1500

gtagacatag ggaatggatg cttcgaaacc aaacacaagt gcaaccagac ctgcttagac     1560

aggatagctg ctggcacctt taatgcagga gaattttctc ttcccacttt tgattcactg     1620

aatattactg ctgcatcttt aaatgatgat ggattggata atcatactat actgctctac     1680

tactcaactg ctgcttctag tttggccgta acattgatga tagctatttt tattgtttat     1740

atggtctcca gagacaatgt ttcttgctcc atctgtctat aaggaaaatt aagccctgta     1800

ttttccttta ttgtagtgct tgtttgcttg ttaccattac aaagaaacgt tattgaaaaa     1860

tgctcttgtt tactactagg aaaattaagc cctgtatttt cctttattgt agtgcttgtt     1920

tgcttgttac cattacaaag aaacgttatt gaaaaatgct cttgttacta ct             1972


<210>  189
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence located between residues 222 and 230 (N2 
       numbering) in the enzymatic active site of NA

<400>  189

Ile Leu Arg Thr Gln Glu Ser Glu Cys 
1               5                   


