                         SEQUENCE LISTING

<110>  Edinburgh Research and Innovation Limited
 
<120>  IMMUNOMODULATORY AGENT

<130>  P229647WO

<140>  PCT/GB 2018/052298
<141>  2018-08-13

<150>  GB 1712952.9
<151>  2017-08-11

<160>  55    

<170>  PatentIn version 3.5

<210>  1
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full length HpARI-1

<400>  1

Met Tyr Arg Leu Phe Leu Val Leu Gly Phe Leu Thr Phe Ile Asn Ala 
1               5                   10                  15      


Ala Asn Leu Arg Cys Lys Phe Thr Asp Glu Glu Arg Asp Lys Gly Tyr 
            20                  25                  30          


Thr Gly Met Leu Val Asn Gly Lys Glu Arg Lys Ala Ala Arg Asn Gly 
        35                  40                  45              


Thr Thr Val Glu Leu Ile Cys Gly Arg Gly Asn His Asn Tyr Thr Cys 
    50                  55                  60                  


Thr Ser Gly His Leu Thr Ala Asn Ser Leu Arg Gln Glu Arg Cys Gly 
65                  70                  75                  80  


Cys Asp Gly Leu Phe Glu Thr Leu Phe Asp Met Pro Lys Glu Lys Arg 
                85                  90                  95      


Pro Ser Pro Met Tyr Ser Asp Ile Thr Tyr Asp Met Pro Asn Met Pro 
            100                 105                 110         


Asn Ile Pro Arg Val Gly Arg His Gly Ile Trp Asn Gly Val Asp Tyr 
        115                 120                 125             


Arg Asn Gly Ser Val Thr Arg Pro Tyr Cys Glu Thr Gly Pro Val Ile 
    130                 135                 140                 


Asn Gly Ser Pro Lys Ala Val Cys Val Ser Gly Arg Trp Val Pro Glu 
145                 150                 155                 160 


Leu Gly Asp Cys Pro Arg Met Cys Ser Leu Ser Ser Leu Lys Glu Ser 
                165                 170                 175     


Gly Lys Phe Leu Cys Val Asn Ala Thr Thr Lys Gly Glu Glu Leu Asn 
            180                 185                 190         


Pro Met Pro Arg Leu Ala Gln Leu Ile Pro Ile Val Arg Asn Val Asn 
        195                 200                 205             


Glu Asp Glu Val Gln His Arg Val Lys Ala Arg Ala Phe Cys Lys Ala 
    210                 215                 220                 


Glu Ser Ser Thr Thr Ala Ala Asp His Val Gln Glu Phe Glu Cys Asp 
225                 230                 235                 240 


Asn Gly Lys Trp Lys Pro Glu Pro Val Pro Cys Pro 
                245                 250         


<210>  2
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HpARI domain 1 of HpARI-1

<400>  2

Ala Asn Leu Arg Cys Lys Phe Thr Asp Glu Glu Arg Asp Lys Gly Tyr 
1               5                   10                  15      


Thr Gly Met Leu Val Asn Gly Lys Glu Arg Lys Ala Ala Arg Asn Gly 
            20                  25                  30          


Thr Thr Val Glu Leu Ile Cys Gly Arg Gly Asn His Asn Tyr Thr Cys 
        35                  40                  45              


Thr Ser Gly His Leu Thr Ala Asn Ser Leu Arg Gln Glu Arg Cys 
    50                  55                  60              


<210>  3
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HpARI domain 2 of HpARI-1

<400>  3

Gly Cys Asp Gly Leu Phe Glu Thr Leu Phe Asp Met Pro Lys Glu Lys 
1               5                   10                  15      


Arg Pro Ser Pro Met Tyr Ser Asp Ile Thr Tyr Asp Met Pro Asn Met 
            20                  25                  30          


Pro Asn Ile Pro Arg Val Gly Arg His Gly Ile Trp Asn Gly Val Asp 
        35                  40                  45              


Tyr Arg Asn Gly Ser Val Thr Arg Pro Tyr Cys Glu Thr Gly Pro Val 
    50                  55                  60                  


Ile Asn Gly Ser Pro Lys Ala Val Cys Val Ser Gly Arg Trp Val Pro 
65                  70                  75                  80  


Glu Leu Gly Asp Cys Pro Arg 
                85          


<210>  4
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HpARI domain 3 of HpARI-1

<400>  4

Met Cys Ser Leu Ser Ser Leu Lys Glu Ser Gly Lys Phe Leu Cys Val 
1               5                   10                  15      


Asn Ala Thr Thr Lys Gly Glu Glu Leu Asn Pro Met Pro Arg Leu Ala 
            20                  25                  30          


Gln Leu Ile Pro Ile Val Arg Asn Val Asn Glu Asp Glu Val Gln His 
        35                  40                  45              


Arg Val Lys Ala Arg Ala Phe Cys Lys Ala Glu Ser Ser Thr Thr Ala 
    50                  55                  60                  


Ala Asp His Val Gln Glu Phe Glu Cys Asp Asn Gly Lys Trp Lys Pro 
65                  70                  75                  80  


Glu Pro Val Pro Cys Pro 
                85      


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal Sequence of HpARI-1

<400>  5

Met Tyr Arg Leu Phe Leu Val Leu Gly Phe Leu Thr Phe Ile Asn Ala 
1               5                   10                  15      


<210>  6
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full length HpARI-2

<400>  6

Met Tyr Arg Leu Phe Leu Ala Leu Gly Phe Leu Thr Phe Ile Asn Ala 
1               5                   10                  15      


Ala Gly Gln Arg Cys Arg Phe Thr Asp Val Glu Arg Asp Lys Gly Tyr 
            20                  25                  30          


Thr Gly Met Leu Leu Lys Gly Arg Leu Arg Lys Thr Ala Gly Asn Gly 
        35                  40                  45              


Arg Thr Val Glu Leu Ile Cys Gly Arg Gly Asn His Asn Tyr Thr Cys 
    50                  55                  60                  


Glu Ser Gly Val Leu Lys Glu Ser Ser Pro Arg Gln Ala Arg Cys Gly 
65                  70                  75                  80  


Cys Lys Gly Ile Leu Glu Met Leu Phe Asp Met Pro Lys Glu Glu Arg 
                85                  90                  95      


Pro Ser Pro Met Tyr Asp Ser Val Thr Tyr Asp Pro Thr Pro Asn Thr 
            100                 105                 110         


Pro Thr Thr Val Gly Lys Asp Gly Ile Trp Asn Gly Val Asp Tyr Arg 
        115                 120                 125             


Asn Gly Ser Thr Val Lys Pro Tyr Cys Asp Thr Gly Pro Val Ile Asn 
    130                 135                 140                 


Gly Ser Ser Lys Ala Val Cys Val Ser Gly Lys Trp Val Pro Thr Leu 
145                 150                 155                 160 


Gly Val Cys Pro Lys Met Cys Ser Ile Gly Ser Leu Lys Glu Asn Gly 
                165                 170                 175     


Lys Phe Val Asp Val Thr Ala Thr Thr Lys Gly Asp Glu Leu Asn Pro 
            180                 185                 190         


Pro Pro Arg Glu Gln Thr Leu Ile Pro Ile Val Arg Lys Val Asp Lys 
        195                 200                 205             


Asp Lys Val Gln His Gly Val Lys Val Val Ala Leu Cys Lys Ala Glu 
    210                 215                 220                 


Asp Ser Thr Thr Ala Ala Glu Gly Val Gln Glu Phe Glu Cys Asp Asn 
225                 230                 235                 240 


Gly Lys Trp Lys Pro Glu Pro Val Pro Cys Pro 
                245                 250     


<210>  7
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HpARI domain 1 of HpARI-2

<400>  7

Ala Gly Gln Arg Cys Arg Phe Thr Asp Val Glu Arg Asp Lys Gly Tyr 
1               5                   10                  15      


Thr Gly Met Leu Leu Lys Gly Arg Leu Arg Lys Thr Ala Gly Asn Gly 
            20                  25                  30          


Arg Thr Val Glu Leu Ile Cys Gly Arg Gly Asn His Asn Tyr Thr Cys 
        35                  40                  45              


Glu Ser Gly Val Leu Lys Glu Ser Ser Pro Arg Gln Ala Arg Cys 
    50                  55                  60              


<210>  8
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HpARI domain 2 of HpARI-2

<400>  8

Gly Cys Lys Gly Ile Leu Glu Met Leu Phe Asp Met Pro Lys Glu Glu 
1               5                   10                  15      


Arg Pro Ser Pro Met Tyr Asp Ser Val Thr Tyr Asp Pro Thr Pro Asn 
            20                  25                  30          


Thr Pro Thr Thr Val Gly Lys Asp Gly Ile Trp Asn Gly Val Asp Tyr 
        35                  40                  45              


Arg Asn Gly Ser Thr Val Lys Pro Tyr Cys Asp Thr Gly Pro Val Ile 
    50                  55                  60                  


Asn Gly Ser Ser Lys Ala Val Cys Val Ser Gly Lys Trp Val Pro Thr 
65                  70                  75                  80  


Leu Gly Val Cys Pro Lys 
                85      


<210>  9
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HpARI domain 3 of HpARI-2

<400>  9

Met Cys Ser Ile Gly Ser Leu Lys Glu Asn Gly Lys Phe Val Asp Val 
1               5                   10                  15      


Thr Ala Thr Thr Lys Gly Asp Glu Leu Asn Pro Pro Pro Arg Glu Gln 
            20                  25                  30          


Thr Leu Ile Pro Ile Val Arg Lys Val Asp Lys Asp Lys Val Gln His 
        35                  40                  45              


Gly Val Lys Val Val Ala Leu Cys Lys Ala Glu Asp Ser Thr Thr Ala 
    50                  55                  60                  


Ala Glu Gly Val Gln Glu Phe Glu Cys Asp Asn Gly Lys Trp Lys Pro 
65                  70                  75                  80  


Glu Pro Val Pro Cys Pro 
                85      


<210>  10
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal Sequence of HpARI-2

<400>  10

Met Tyr Arg Leu Phe Leu Ala Leu Gly Phe Leu Thr Phe Ile Asn Ala 
1               5                   10                  15      


<210>  11
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full length HpARI-3

<400>  11

Met Tyr Arg Ile Ile Leu Thr Leu Gly Phe Leu Thr Phe Ile Asn Ala 
1               5                   10                  15      


Ala Ser Leu Gly Cys Lys Phe Thr Asp Val Glu Lys Asp Lys Gly Tyr 
            20                  25                  30          


Thr Gly Met Leu Val Gly Gly Lys Arg Arg Glu Ser Ala Ala Asn Gly 
        35                  40                  45              


Gln Lys Val Glu Leu Val Cys Gly Arg Gly Asn His Asn Tyr Thr Cys 
    50                  55                  60                  


Lys Ser Gly Ile Leu Thr Glu Glu Ser Tyr Arg Gln Gly Arg Cys Gly 
65                  70                  75                  80  


Cys Glu Gly Ile Leu Gln Met Leu Leu Asp Lys Pro Lys Asp Ser Pro 
                85                  90                  95      


Met Tyr Asp Ser Val Thr Tyr Asp Pro Thr Pro Asn Thr Pro Thr Thr 
            100                 105                 110         


Val Gly Lys Asp Gly Ile Trp Asn Gly Val Asp Tyr Arg Asn Gly Ser 
        115                 120                 125             


Thr Val Arg Pro Tyr Cys Asp Thr Gly Pro Ile Ile Asn Gly Ser Pro 
    130                 135                 140                 


Lys Ala Val Cys Val Ser Gly Lys Trp Val Pro Lys Leu Gly Asp Cys 
145                 150                 155                 160 


Pro Lys Met Cys Ser Ile Ser Ser Leu Lys Glu Asn Gly Lys Phe Leu 
                165                 170                 175     


Asn Val Thr Ala Thr Thr Thr Gly Asp Glu Leu Asn Pro Arg Pro Arg 
            180                 185                 190         


Glu Gln Thr Leu Ile Pro Ile Val Arg Lys Val Asp Lys Asp Lys Val 
        195                 200                 205             


Gln His Gly Val Lys Val Val Ala Leu Cys Lys Ala Lys Tyr Ser Thr 
    210                 215                 220                 


Thr Ala Ala Glu Asn Val Gln Lys Phe Glu Cys Asp Asn Gly Lys Trp 
225                 230                 235                 240 


Lys Pro Lys Pro Val Pro Cys Ser 
                245             


<210>  12
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HpARI domain 1 of HpARI-3

<400>  12

Ala Ser Leu Gly Cys Lys Phe Thr Asp Val Glu Lys Asp Lys Gly Tyr 
1               5                   10                  15      


Thr Gly Met Leu Val Gly Gly Lys Arg Arg Glu Ser Ala Ala Asn Gly 
            20                  25                  30          


Gln Lys Val Glu Leu Val Cys Gly Arg Gly Asn His Asn Tyr Thr Cys 
        35                  40                  45              


Lys Ser Gly Ile Leu Thr Glu Glu Ser Tyr Arg Gln Gly Arg Cys 
    50                  55                  60              


<210>  13
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HpARI domain 2 of HpARI-3

<400>  13

Gly Cys Glu Gly Ile Leu Gln Met Leu Leu Asp Lys Pro Lys Asp Ser 
1               5                   10                  15      


Pro Met Tyr Asp Ser Val Thr Tyr Asp Pro Thr Pro Asn Thr Pro Thr 
            20                  25                  30          


Thr Val Gly Lys Asp Gly Ile Trp Asn Gly Val Asp Tyr Arg Asn Gly 
        35                  40                  45              


Ser Thr Val Arg Pro Tyr Cys Asp Thr Gly Pro Ile Ile Asn Gly Ser 
    50                  55                  60                  


Pro Lys Ala Val Cys Val Ser Gly Lys Trp Val Pro Lys Leu Gly Asp 
65                  70                  75                  80  


Cys Pro Lys 
            


<210>  14
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HpARI domain 3 of HpARI-3

<400>  14

Met Cys Ser Ile Ser Ser Leu Lys Glu Asn Gly Lys Phe Leu Asn Val 
1               5                   10                  15      


Thr Ala Thr Thr Thr Gly Asp Glu Leu Asn Pro Arg Pro Arg Glu Gln 
            20                  25                  30          


Thr Leu Ile Pro Ile Val Arg Lys Val Asp Lys Asp Lys Val Gln His 
        35                  40                  45              


Gly Val Lys Val Val Ala Leu Cys Lys Ala Lys Tyr Ser Thr Thr Ala 
    50                  55                  60                  


Ala Glu Asn Val Gln Lys Phe Glu Cys Asp Asn Gly Lys Trp Lys Pro 
65                  70                  75                  80  


Lys Pro Val Pro Cys Ser 
                85      


<210>  15
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal Sequence of HpARI-3

<400>  15

Met Tyr Arg Ile Ile Leu Thr Leu Gly Phe Leu Thr Phe Ile Asn Ala 
1               5                   10                  15      


<210>  16
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HpARI domain 1


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  x = N/G/S

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  x = L/Q

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  x = R/G

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  x = K/R

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  x = E/V

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  x =  R/K

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  x = V/L

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  x = N/K/G

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  x = K/R

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  x = E/L/R

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  x = K/E

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  x = A/T/S

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  x = R/G/A

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  x = T/R/Q

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  x = T/K

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  X = I/V

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  x = T/E/K

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  x = H/V/I

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  x = T/K

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  x = A/E

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  x = N/S/E

<220>
<221>  MISC_FEATURE
<222>  (58)..(58)
<223>  x = L/P/Y

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  x = E/A/G

<400>  16

Ala Xaa Xaa Xaa Cys Xaa Phe Thr Asp Xaa Glu Xaa Asp Lys Gly Tyr 
1               5                   10                  15      


Thr Gly Met Leu Xaa Xaa Gly Xaa Xaa Arg Xaa Xaa Ala Xaa Asn Gly 
            20                  25                  30          


Xaa Xaa Val Glu Leu Xaa Cys Gly Arg Gly Asn His Asn Tyr Thr Cys 
        35                  40                  45              


Xaa Ser Gly Xaa Leu Xaa Xaa Xaa Ser Xaa Arg Gln Xaa Arg Cys 
    50                  55                  60              


<210>  17
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HpARI domain 2


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  x = D/K/E

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  x = L/I

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  x = F/L

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  x = Q/E

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  x = M/T

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  x = F/L

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  x = M/K

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  x = E/D

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  x = K/E/no amino acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  x = R/no amino acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  x = P/no amino acid

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  x = S/D

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  x = D/S

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  x = I/V

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  x = M/P

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  x = P/T

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  x = N/P

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  x = M/N

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  x = P/T

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  x = N/P

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  x = I/no amino acid

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  x = P/T

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  x = R/T

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  x = R/K

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  x = H/D

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  x = V/T

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  x = T/V

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  x = R/K

<220>
<221>  MISC_FEATURE
<222>  (60)..(60)
<223>  x = E/D

<220>
<221>  MISC_FEATURE
<222>  (64)..(64)
<223>  x = V/I

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  x = P/S

<220>
<221>  MISC_FEATURE
<222>  (77)..(77)
<223>  x = R/K

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  x = E/T/K

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  x = D/V

<220>
<221>  MISC_FEATURE
<222>  (87)..(87)
<223>  x = R/K

<400>  17

Gly Cys Xaa Gly Xaa Xaa Xaa Xaa Leu Xaa Asp Xaa Pro Lys Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Ser Pro Met Tyr Xaa Xaa Xaa Thr Tyr Asp Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Val Gly Xaa Xaa Gly Ile Trp Asn Gly Val Asp 
        35                  40                  45              


Tyr Arg Asn Gly Ser Xaa Xaa Xaa Pro Tyr Cys Xaa Thr Gly Pro Xaa 
    50                  55                  60                  


Ile Asn Gly Ser Xaa Lys Ala Val Cys Val Ser Gly Xaa Trp Val Pro 
65                  70                  75                  80  


Xaa Leu Gly Xaa Cys Pro Xaa 
                85          


<210>  18
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HpARI domain 2


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  x = L/I

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  x = F/L

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  x = Q/E

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  x = M/T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  x = F/L

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  x = M/K

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  x = E/D

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  x = K/E/no amino acid

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  x = R/no amino acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  x = P/no amino acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  x = S/D

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  x = D/S

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  x = I/V

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  x = M/P

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  x = P/T

<400>  18

Gly Xaa Xaa Xaa Xaa Leu Xaa Asp Xaa Pro Lys Xaa Xaa Xaa Xaa Ser 
1               5                   10                  15      


Pro Met Tyr Xaa Xaa Xaa Thr Tyr Asp Xaa Xaa 
            20                  25          


<210>  19
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HpARI domain 2

<400>  19

Gly Leu Phe Glu Thr Leu Phe Asp Met Pro Lys Glu Lys Arg Pro Ser 
1               5                   10                  15      


Pro Met Tyr Ser Asp Ile Thr Tyr Asp Met Pro 
            20                  25          


<210>  20
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HpARI domain 2

<400>  20

Gly Ile Leu Glu Met Leu Phe Asp Met Pro Lys Glu Glu Arg Pro Ser 
1               5                   10                  15      


Pro Met Tyr Asp Ser Val Thr Tyr Asp Pro Thr 
            20                  25          


<210>  21
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HpARI domain 2

<400>  21

Gly Ile Leu Gln Met Leu Leu Asp Lys Pro Lys Asp Ser Pro Met Tyr 
1               5                   10                  15      


Asp Ser Val Thr Tyr Asp Pro Thr 
            20                  


<210>  22
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HpARI domain 3


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  x= L/I

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  x = S/G

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  x = S/N

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  x = L/V

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  x = C/D/N

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  x = N/T

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  x = K/T

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  x = E/D

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  x = M/P/R,

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  x = L/E

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  x = A/Q

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  x = Q/T

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  x = N/K

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  x = N/D

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  x = E/K

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  x = E/K

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  x = R/G

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  x = A/V

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  x = R/V

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  x = F/L

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  x = E/K

<220>
<221>  MISC_FEATURE
<222>  (60)..(60)
<223>  x = S/D/Y

<220>
<221>  MISC_FEATURE
<222>  (66)..(66)
<223>  x = D/E

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  x = H/G/N

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  x = E/K

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  x = E/K

<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  x = P/S

<400>  22

Met Cys Ser Xaa Xaa Ser Leu Lys Glu Xaa Gly Lys Phe Xaa Xaa Val 
1               5                   10                  15      


Xaa Ala Thr Thr Xaa Gly Xaa Glu Leu Asn Pro Xaa Pro Arg Xaa Xaa 
            20                  25                  30          


Xaa Leu Ile Pro Ile Val Arg Xaa Val Xaa Xaa Asp Xaa Val Gln His 
        35                  40                  45              


Xaa Val Lys Xaa Xaa Ala Xaa Cys Lys Ala Xaa Xaa Ser Thr Thr Ala 
    50                  55                  60                  


Ala Xaa Xaa Val Gln Xaa Phe Glu Cys Asp Asn Gly Lys Trp Lys Pro 
65                  70                  75                  80  


Xaa Pro Val Pro Cys Xaa 
                85      


<210>  23
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HpARI domain 3


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  x = L/I

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  x = S/G

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  x = S/N

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  x = L/V

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  x = C/D/N

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  x = N/T

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  x = K/T

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  x = E/D

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  x = M/P/R

<400>  23

Xaa Xaa Ser Leu Lys Glu Xaa Gly Lys Phe Xaa Xaa Val Xaa Ala Thr 
1               5                   10                  15      


Thr Xaa Gly Xaa Glu Leu Asn Pro Xaa 
            20                  25  


<210>  24
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HpARI domain 3

<400>  24

Leu Ser Ser Leu Lys Glu Ser Gly Lys Phe Leu Cys Val Asn Ala Thr 
1               5                   10                  15      


Thr Lys Gly Glu Glu Leu Asn Pro Met 
            20                  25  


<210>  25
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HpARI domain 3

<400>  25

Ile Gly Ser Leu Lys Glu Asn Gly Lys Phe Val Asp Val Thr Ala Thr 
1               5                   10                  15      


Thr Lys Gly Asp Glu Leu Asn Pro Pro 
            20                  25  


<210>  26
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HpARI domain 3

<400>  26

Ile Ser Ser Leu Lys Glu Asn Gly Lys Phe Leu Asn Val Thr Ala Thr 
1               5                   10                  15      


Thr Thr Gly Asp Glu Leu Asn Pro Arg 
            20                  25  


<210>  27
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HpARI domain 3


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  x = N/G/S

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  x = L/Q

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  x = R/G

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  x = K/R

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  x = E/V

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  x =  R/K

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  x = V/L

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  x = N/K/G

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  x = K/R

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  x = E/L/R

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  x = K/E

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  x = A/T/S

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  x = R/G/A

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  x = T/R/Q

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  x = T/K

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  x = I/V

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  x = T/E/K

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  x = H/V/I

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  x = T/K

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  x = A/E

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  x = N/S/E

<220>
<221>  MISC_FEATURE
<222>  (58)..(58)
<223>  x = L/P/Y

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  x = E/A/G

<220>
<221>  MISC_FEATURE
<222>  (66)..(66)
<223>  x = D/K/E

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  x = L/I

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  x = F/L

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  x = Q/E

<220>
<221>  MISC_FEATURE
<222>  (71)..(71)
<223>  x = M/T

<220>
<221>  MISC_FEATURE
<222>  (73)..(73)
<223>  x = F/L

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  x = M/K

<220>
<221>  MISC_FEATURE
<222>  (78)..(78)
<223>  x = E/D

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  x = K/E/no amino acid

<220>
<221>  MISC_FEATURE
<222>  (80)..(80)
<223>  x = R/no amino acid

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  x = P/no amino acid

<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  x = S/D

<220>
<221>  MISC_FEATURE
<222>  (87)..(87)
<223>  x = D/S

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  x = I/V

<220>
<221>  MISC_FEATURE
<222>  (92)..(92)
<223>  x = M/P

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  x = P/T

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  x = N/P

<220>
<221>  MISC_FEATURE
<222>  (95)..(95)
<223>  x = M/N

<220>
<221>  MISC_FEATURE
<222>  (96)..(96)
<223>  x = P/T

<220>
<221>  MISC_FEATURE
<222>  (97)..(97)
<223>  x = N/P

<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  x = I/no amino acid

<220>
<221>  MISC_FEATURE
<222>  (99)..(99)
<223>  x = P/T

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  x = R/T

<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  x = R/K

<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  x = H/D

<220>
<221>  MISC_FEATURE
<222>  (117)..(117)
<223>  x = V/T

<220>
<221>  MISC_FEATURE
<222>  (118)..(118)
<223>  x = T/V

<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  x = R/K

<220>
<221>  MISC_FEATURE
<222>  (123)..(123)
<223>  x = E/D

<220>
<221>  MISC_FEATURE
<222>  (127)..(127)
<223>  x = V/I

<220>
<221>  MISC_FEATURE
<222>  (132)..(132)
<223>  x = P/S

<220>
<221>  MISC_FEATURE
<222>  (140)..(140)
<223>  x = R/K

<220>
<221>  MISC_FEATURE
<222>  (144)..(144)
<223>  x = E/T/K

<220>
<221>  MISC_FEATURE
<222>  (147)..(147)
<223>  x = D/V

<220>
<221>  MISC_FEATURE
<222>  (150)..(150)
<223>  x = R/K

<220>
<221>  MISC_FEATURE
<222>  (154)..(154)
<223>  x = L/I

<220>
<221>  MISC_FEATURE
<222>  (155)..(155)
<223>  x = S/G

<220>
<221>  MISC_FEATURE
<222>  (160)..(160)
<223>  x = S/N

<220>
<221>  MISC_FEATURE
<222>  (164)..(164)
<223>  x = L/V

<220>
<221>  MISC_FEATURE
<222>  (165)..(165)
<223>  x = C/D/N

<220>
<221>  MISC_FEATURE
<222>  (167)..(167)
<223>  x = N/T

<220>
<221>  MISC_FEATURE
<222>  (171)..(171)
<223>  x = K/T

<220>
<221>  MISC_FEATURE
<222>  (173)..(173)
<223>  x = E/D

<220>
<221>  MISC_FEATURE
<222>  (178)..(178)
<223>  x = M/P/R

<220>
<221>  MISC_FEATURE
<222>  (181)..(181)
<223>  x = L/E

<220>
<221>  MISC_FEATURE
<222>  (182)..(182)
<223>  x = A/Q

<220>
<221>  MISC_FEATURE
<222>  (183)..(183)
<223>  x = Q/T

<220>
<221>  MISC_FEATURE
<222>  (190)..(190)
<223>  x = N/K

<220>
<221>  MISC_FEATURE
<222>  (192)..(192)
<223>  x = N/D

<220>
<221>  MISC_FEATURE
<222>  (193)..(193)
<223>  x = E/K

<220>
<221>  MISC_FEATURE
<222>  (195)..(195)
<223>  x = E/K

<220>
<221>  MISC_FEATURE
<222>  (199)..(199)
<223>  x = R/G

<220>
<221>  MISC_FEATURE
<222>  (202)..(202)
<223>  x = A/V

<220>
<221>  MISC_FEATURE
<222>  (203)..(203)
<223>  x = R/V

<220>
<221>  MISC_FEATURE
<222>  (205)..(205)
<223>  x = F/L

<220>
<221>  MISC_FEATURE
<222>  (209)..(209)
<223>  x = E/K

<220>
<221>  MISC_FEATURE
<222>  (210)..(210)
<223>  x = S/D/Y

<220>
<221>  MISC_FEATURE
<222>  (216)..(216)
<223>  x = D/E

<220>
<221>  MISC_FEATURE
<222>  (217)..(217)
<223>  x = H/G/N

<220>
<221>  MISC_FEATURE
<222>  (220)..(220)
<223>  x = E/K

<220>
<221>  MISC_FEATURE
<222>  (231)..(231)
<223>  x = E/K

<220>
<221>  MISC_FEATURE
<222>  (236)..(236)
<223>  x = P/S

<400>  27

Ala Xaa Xaa Xaa Cys Xaa Phe Thr Asp Xaa Glu Xaa Asp Lys Gly Tyr 
1               5                   10                  15      


Thr Gly Met Leu Xaa Xaa Gly Xaa Xaa Arg Xaa Xaa Ala Xaa Asn Gly 
            20                  25                  30          


Xaa Xaa Val Glu Leu Xaa Cys Gly Arg Gly Asn His Asn Tyr Thr Cys 
        35                  40                  45              


Xaa Ser Gly Xaa Leu Xaa Xaa Xaa Ser Xaa Arg Gln Xaa Arg Cys Gly 
    50                  55                  60                  


Cys Xaa Gly Xaa Xaa Xaa Xaa Leu Xaa Asp Xaa Pro Lys Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Ser Pro Met Tyr Xaa Xaa Xaa Thr Tyr Asp Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Val Gly Xaa Xaa Gly Ile Trp Asn Gly Val Asp Tyr 
            100                 105                 110         


Arg Asn Gly Ser Xaa Xaa Xaa Pro Tyr Cys Xaa Thr Gly Pro Xaa Ile 
        115                 120                 125             


Asn Gly Ser Xaa Lys Ala Val Cys Val Ser Gly Xaa Trp Val Pro Xaa 
    130                 135                 140                 


Leu Gly Xaa Cys Pro Xaa Met Cys Ser Xaa Xaa Ser Leu Lys Glu Xaa 
145                 150                 155                 160 


Gly Lys Phe Xaa Xaa Val Xaa Ala Thr Thr Xaa Gly Xaa Glu Leu Asn 
                165                 170                 175     


Pro Xaa Pro Arg Xaa Xaa Xaa Leu Ile Pro Ile Val Arg Xaa Val Xaa 
            180                 185                 190         


Xaa Asp Xaa Val Gln His Xaa Val Lys Xaa Xaa Ala Xaa Cys Lys Ala 
        195                 200                 205             


Xaa Xaa Ser Thr Thr Ala Ala Xaa Xaa Val Gln Xaa Phe Glu Cys Asp 
    210                 215                 220                 


Asn Gly Lys Trp Lys Pro Xaa Pro Val Pro Cys Xaa 
225                 230                 235     


<210>  28
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding SEQ ID NO: 1

<400>  28
atgtatcgcc ttttcctcgt tttaggcttc ctcaccttca tcaacgctgc aaacctgcgc       60

tgcaaattca ccgatgaaga gagagacaaa ggctacactg gaatgctagt caacggaaag      120

gaaagaaagg cagcaagaaa cggaacgacg gtagaattga tatgtggaag aggaaatcac      180

aactacacct gcacgtctgg tcatttgacc gcaaattctc tgcggcaaga gagatgtggt      240

tgcgacggac ttttcgaaac gctattcgat atgcctaagg aaaaacggcc ttcgcccatg      300

tacagtgata tcacctatga catgcccaac atgcccaaca tcccacgtgt aggaaggcac      360

ggaatttgga acggggtgga ttaccggaat ggttccgtaa cgaggcctta ttgcgaaact      420

ggtccagtca tcaatggatc acccaaagct gtatgtgtga gtggcagatg ggttcctgag      480

cttggagact gcccaaggat gtgttcgctc agcagcttga aggaaagcgg gaaattcctg      540

tgcgtcaatg caacaactaa aggggaagag ctcaacccta tgccaaggct agcgcagttg      600

attcctatcg tgcgcaacgt taacgaagac gaggtccaac accgagtcaa agctagggcc      660

ttctgcaaag ccgaaagttc cacaactgcc gctgatcatg tccaggaatt cgaatgtgac      720

aacgggaagt ggaagccaga gcccgtgccc tgccca                                756


<210>  29
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding SEQ ID NO: 2

<400>  29
gcaaacctgc gctgcaaatt caccgatgaa gagagagaca aaggctacac tggaatgcta       60

gtcaacggaa aggaaagaaa ggcagcaaga aacggaacga cggtagaatt gatatgtgga      120

agaggaaatc acaactacac ctgcacgtct ggtcatttga ccgcaaattc tctgcggcaa      180

gagagatgtg caaacctgcg ctgcaaattc accgatgaag agagagacaa aggctacact      240

ggaatgctag tcaacggaaa ggaaagaaag gcagcaagaa acggaacgac ggtagaattg      300

atatgtggaa gaggaaatca caactacacc tgcacgtctg gtcatttgac cgcaaattct      360

ctgcggcaag agagatgt                                                    378


<210>  30
<211>  261
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding SEQ ID NO: 3

<400>  30
ggttgcgacg gacttttcga aacgctattc gatatgccta aggaaaaacg gccttcgccc       60

atgtacagtg atatcaccta tgacatgccc aacatgccca acatcccacg tgtaggaagg      120

cacggaattt ggaacggggt ggattaccgg aatggttccg taacgaggcc ttattgcgaa      180

actggtccag tcatcaatgg atcacccaaa gctgtatgtg tgagtggcag atgggttcct      240

gagcttggag actgcccaag g                                                261


<210>  31
<211>  258
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding SEQ ID NO: 4

<400>  31
atgtgttcgc tcagcagctt gaaggaaagc gggaaattcc tgtgcgtcaa tgcaacaact       60

aaaggggaag agctcaaccc tatgccaagg ctagcgcagt tgattcctat cgtgcgcaac      120

gttaacgaag acgaggtcca acaccgagtc aaagctaggg ccttctgcaa agccgaaagt      180

tccacaactg ccgctgatca tgtccaggaa ttcgaatgtg acaacgggaa gtggaagcca      240

gagcccgtgc cctgccca                                                    258


<210>  32
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding SEQ ID NO: 5

<400>  32
atgtatcgcc ttttcctcgt tttaggcttc ctcaccttca tcaacgct                    48


<210>  33
<211>  754
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding SEQ ID NO:6

<400>  33
atgtatcgcc tttttctcgc tttaggcttc ctcaccttca tcaacgcttg caggtcagcg       60

ctgcagattc accgatgtag aaagagacaa aggctacact ggaatgctcc ttaaaggaag      120

gttaagaaag acagctggaa acgggaggac ggtagaattg atatgtggaa gaggaaatca      180

caactacacc tgcgagtccg gcgttttgaa ggaaagttct ccacggcaag cccgatgtgg      240

ttgcaaggga attctcgaaa tgctcttcga tatgcctaag gaagaacggc cctcgcccat      300

gtacgactca gtcacctatg accccacgcc caacacccca acaactgtag gaaaggacgg      360

gatatggaac ggagtagatt accgcaatgg ctctacagtg aagccttatt gcgatactgg      420

tccagtcatc aacggatcat ccaaagctgt atgtgtgagt ggcaaatggg ttcctacgct      480

tggcgtctgc ccaaaaatgt gttcgatcgg cagcttgaag gaaaatggga aattcgtaga      540

cgtcacagca acaactaaag gagacgagct caaccccccg ccaagggaac agacattgat      600

tcctatagtg cgtaaagttg acaaagacaa ggtccaacac ggcgtcaaag ttgttgctct      660

ttgtaaagcc gaagattcta caactgccgc tgaaggcgtc caggaattcg aatgtgacaa      720

cgggaagtgg aagccagagc ccgtgccctg cccc                                  754


<210>  34
<211>  190
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding SEQ ID NO: 7

<400>  34
tgcaggtcag cgctgcagat tcaccgatgt agaaagagac aaaggctaca ctggaatgct       60

ccttaaagga aggttaagaa agacagctgg aaacgggagg acggtagaat tgatatgtgg      120

aagaggaaat cacaactaca cctgcgagtc cggcgttttg aaggaaagtt ctccacggca      180

agcccgatgt                                                             190


<210>  35
<211>  258
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding SEQ ID NO: 8

<400>  35
ggttgcaagg gaattctcga aatgctcttc gatatgccta aggaagaacg gccctcgccc       60

atgtacgact cagtcaccta tgaccccacg cccaacaccc caacaactgt aggaaaggac      120

gggatatgga acggagtaga ttaccgcaat ggctctacag tgaagcctta ttgcgatact      180

ggtccagtca tcaacggatc atccaaagct gtatgtgtga gtggcaaatg ggttcctacg      240

cttggcgtct gcccaaaa                                                    258


<210>  36
<211>  258
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding SEQ ID NO: 9

<400>  36
atgtgttcga tcggcagctt gaaggaaaat gggaaattcg tagacgtcac agcaacaact       60

aaaggagacg agctcaaccc cccgccaagg gaacagacat tgattcctat agtgcgtaaa      120

gttgacaaag acaaggtcca acacggcgtc aaagttgttg ctctttgtaa agccgaagat      180

tctacaactg ccgctgaagg cgtccaggaa ttcgaatgtg acaacgggaa gtggaagcca      240

gagcccgtgc cctgcccc                                                    258


<210>  37
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding SEQ ID NO: 10

<400>  37
atgtatcgcc tttttctcgc tttaggcttc ctcaccttca tcaacgct                    48


<210>  38
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding SEQ ID NO: 11

<400>  38
atgtatcgca ttattctcac tttaggcttc ctcaccttta tcaacgctgc aagcctgggt       60

tgcaagttca ccgatgtaga gaaggacaaa ggctatactg gaatgctcgt cggcggaaaa      120

cgaagagagt cagcagcaaa cggacagaag gtagaactgg tatgtggaag aggaaatcac      180

aactacacct gcaagtctgg tattttgacg gaagaatctt accggcaggg gagatgtggt      240

tgcgagggaa ttctccaaat gctcttagac aagcctaagg attcgcccat gtacgattca      300

gtcacctatg atcccacgcc caacacccca acaactgtag gaaaggacgg gatatggaac      360

ggagtagact accggaatgg ctctacagtg aggccttatt gcgatactgg tccaatcatc      420

aacggatcac ccaaagctgt atgtgtgagt ggcaaatggg ttcctaagct tggcgactgc      480

ccaaaaatgt gttcgatcag cagcttgaag gaaaacggta aattcctaaa cgtcacagca      540

acaactacag gagacgagct caaccctagg ccaagggaac agacattgat tcctatagtg      600

cgtaaagttg acaaggacaa ggtccaacac ggcgtcaaag ttgttgctct ttgtaaagcc      660

aaatattcta caactgccgc tgaaaacgtc cagaaattcg aatgtgacaa cgggaagtgg      720

aagccaaagc ccgtgccatg ttca                                             744


<210>  39
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding SEQ ID NO: 12

<400>  39
gcaagcctgg gttgcaagtt caccgatgta gagaaggaca aaggctatac tggaatgctc       60

gtcggcggaa aacgaagaga gtcagcagca aacggacaga aggtagaact ggtatgtgga      120

agaggaaatc acaactacac ctgcaagtct ggtattttga cggaagaatc ttaccggcag      180

gggagatgt                                                              189


<210>  40
<211>  249
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding SEQ ID NO: 13

<400>  40
ggttgcgagg gaattctcca aatgctctta gacaagccta aggattcgcc catgtacgat       60

tcagtcacct atgatcccac gcccaacacc ccaacaactg taggaaagga cgggatatgg      120

aacggagtag actaccggaa tggctctaca gtgaggcctt attgcgatac tggtccaatc      180

atcaacggat cacccaaagc tgtatgtgtg agtggcaaat gggttcctaa gcttggcgac      240

tgcccaaaa                                                              249


<210>  41
<211>  258
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding SEQ ID NO: 14

<400>  41
atgtgttcga tcagcagctt gaaggaaaac ggtaaattcc taaacgtcac agcaacaact       60

acaggagacg agctcaaccc taggccaagg gaacagacat tgattcctat agtgcgtaaa      120

gttgacaagg acaaggtcca acacggcgtc aaagttgttg ctctttgtaa agccaaatat      180

tctacaactg ccgctgaaaa cgtccagaaa ttcgaatgtg acaacgggaa gtggaagcca      240

aagcccgtgc catgttca                                                    258


<210>  42
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding SEQ ID NO: 15

<400>  42
atgtatcgca ttattctcac tttaggcttc ctcaccttta tcaacgct                    48


<210>  43
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding SEQ ID NO 19

<400>  43
ggacttttcg aaacgctatt cgatatgcct aaggaaaaac ggccttcgcc catgtacagt       60

gatatcacct atgacatgcc c                                                 81


<210>  44
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding SEQ ID NO: 20

<400>  44
ggaattctcg aaatgctctt cgatatgcct aaggaagaac ggccctcgcc catgtacgac       60

tcagtcacct atgaccccac g                                                 81


<210>  45
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding SEQ ID NO: 21

<400>  45
ggaattctcc aaatgctctt agacaagcct aaggattcgc ccatgtacga ttcagtcacc       60

tatgatccca cg                                                           72


<210>  46
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding SEQ ID NO: 24

<400>  46
ctcagcagct tgaaggaaag cgggaaattc ctgtgcgtca atgcaacaac taaaggggaa       60

gagctcaacc ctatg                                                        75


<210>  47
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding SEQ ID NO: 25

<400>  47
atcggcagct tgaaggaaaa tgggaaattc gtagacgtca cagcaacaac taaaggagac       60

gagctcaacc ccccg                                                        75


<210>  48
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding SEQ ID NO: 26

<400>  48
atcagcagct tgaaggaaaa cggtaaattc ctaaacgtca cagcaacaac tacaggagac       60

gagctcaacc ctagg                                                        75


<210>  49
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Reference peptide

<300>
<301>  Smith et al.
<302>  Tunable helicity, stability and DNA-binding properties of short 
       peptides with hybrid metal coordination motifs
<303>  Chemical Science
<304>  2016
<305>  7
<306>  5453-5461
<307>  2016-05-18

<400>  49

Lys Arg Ala Arg Asn Thr Glu Ala Ala Arg Arg Ser Arg Ala Arg Lys 
1               5                   10                  15      


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Reference sequence

<300>
<301>  Lee et al.
<302>  DNA binding fluorescent proteins for the direct visualization of 
       large DNA molecules.
<303>  Nucleic Acids Research
<304>  44
<305>  1
<306>  e6
<307>  2015-08-11

<400>  50

Lys Trp Lys Trp Lys Lys Ala 
1               5           


<210>  51
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primes reverse of SEQ ID No. 54

<400>  51
gcggccgcct tggggcacac gcccag                                            26


<210>  52
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primes GCKGIL amino acid sequence, for HpARI-2 CCP2/3 construct

<400>  52
ggcgcgccgg ctgcaagggc atcctg                                            26


<210>  53
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primes MCSIG amino acid sequence, for HpARI-2 CCP3 construct

<400>  53
ggcgcgccat gtgcagcatc ggcag                                             25


<210>  54
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence, for HpARI-2 CCP1/2 construct

<400>  54

Leu Gly Val Cys Pro Lys 
1               5       


<210>  55
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence for HpARI-2 CCP2/3 construct

<400>  55

Gly Cys Lys Gly Ile Leu 
1               5       


