                         SEQUENCE LISTING

<110>  Almirall S.A.
 
<120>  Novel compounds activating the Nrf2 pathway

<130>  N414055WO

<140>  17382558.9
<141>  2017-08-08

<160>  123   

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<400>  1

Leu Gln Trp Asp Glu Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  2
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<400>  2

Leu Gln Cys Asp Glu Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<400>  3

Leu Gln Cys Asp Glu Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  4
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<400>  4

Leu Gln Cys Asp Glu Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  5
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<400>  5

Leu Gln Cys Asp Glu Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  binding site for cyclization

<400>  6

Cys Asp Glu Glu Thr Gly Glu Cys 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  binding site for cyclization

<400>  7

Trp Asp Glu Glu Thr Gly Glu Cys 
1               5               


<210>  8
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  AMIDATION

<400>  8

Leu Gln Trp Asp Glu Glu Thr Gly Glu Cys Leu Pro Xaa Arg Lys Lys 
1               5                   10                  15      


Arg Arg Gln Arg Arg Arg 
            20          


<210>  9
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  AMIDATION

<400>  9

Leu Gln Cys Asp Glu Glu Thr Gly Glu Cys Leu Pro Xaa Arg Lys Lys 
1               5                   10                  15      


Arg Arg Gln Arg Arg Arg 
            20          


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  binding site for cyclization

<400>  10

Phe Asp Glu Glu Thr Gly Glu Cys 
1               5               


<210>  11
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<400>  11

Leu Gln Trp Asp Glu Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  binding site for cyclization

<400>  12

Cys Asp Glu Glu Thr Gly Glu Cys 
1               5               


<210>  13
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  AMIDATION

<400>  13

Leu Gln Cys Asp Glu Glu Thr Gly Glu Cys Leu Pro Xaa Tyr Ala Arg 
1               5                   10                  15      


Ala Ala Ala Arg Gln Ala Arg Ala 
            20                  


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<400>  14

Leu Gln Cys Asp Ala Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  15
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  AMIDATION

<400>  15

Leu Gln Cys Asp Ala Glu Thr Gly Glu Cys Leu Pro Xaa Tyr Ala Arg 
1               5                   10                  15      


Ala Ala Ala Arg Gln Ala Arg Ala 
            20                  


<210>  16
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  AMIDATION

<400>  16

Leu Gln Cys Asp Ala Glu Thr Gly Glu Cys Leu Pro Xaa Arg Lys Lys 
1               5                   10                  15      


Arg Arg Gln Arg Arg Arg 
            20          


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<400>  17

Leu Gln Cys Asp Ala Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  18
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  AMIDATION

<400>  18

Leu Gln Cys Asp Ala Glu Thr Gly Glu Cys Leu Pro Xaa Arg Lys Lys 
1               5                   10                  15      


Arg Arg Gln Arg Arg Arg 
            20          


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<400>  19

Leu Gln Cys Asp Ala Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  binding site for cyclization

<400>  20

Cys Asp Ala Glu Thr Gly Glu Cys 
1               5               


<210>  21
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  AMIDATION

<400>  21

Cys Asp Ala Glu Thr Gly Glu Cys Xaa Arg Lys Lys Arg Arg Gln Arg 
1               5                   10                  15      


Arg Arg 
        


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  binding site for cyclization

<400>  22

Phe Asp Glu Glu Thr Gly Glu Cys 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  binding site for cyclization

<400>  23

Phe Asp Glu Glu Thr Gly Glu Cys 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  binding site for cyclization

<400>  24

Cys Asp Glu Glu Thr Gly Glu Cys 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  binding site for cyclization

<400>  25

Cys Asp Glu Glu Thr Gly Glu Cys 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  binding site for cyclization

<400>  26

Cys Asp Glu Glu Thr Gly Glu Cys 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  binding site for cyclization

<400>  27

Cys Asp Glu Glu Thr Gly Glu Cys 
1               5               


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (2)..(2)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  AMIDATION

<220>
<221>  BINDING
<222>  (9)..(9)
<223>  binding site for cyclization

<400>  28

Xaa Cys Asp Ala Glu Thr Gly Glu Cys 
1               5                   


<210>  29
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (11)..(11)
<223>  binding site for cyclization

<400>  29

Xaa Leu Gln Cys Asp Ala Glu Thr Gly Glu Cys Leu Pro 
1               5                   10              


<210>  30
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  AMIDATION

<400>  30

Leu Gln Cys Asp Ala Glu Thr Gly Glu Cys Leu Pro Xaa Arg Lys Lys 
1               5                   10                  15      


Arg Arg Gln Arg Arg Arg 
            20          


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (2)..(2)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  AMIDATION

<220>
<221>  BINDING
<222>  (9)..(9)
<223>  binding site for cyclization

<400>  31

Xaa Cys Asp Pro Glu Thr Gly Glu Cys 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (2)..(2)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  AMIDATION

<220>
<221>  BINDING
<222>  (9)..(9)
<223>  binding site for cyclization

<400>  32

Xaa Cys Asp Pro Glu Thr Gly Glu Cys 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (2)..(2)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  AMIDATION

<220>
<221>  BINDING
<222>  (9)..(9)
<223>  binding site for cyclization

<400>  33

Xaa Cys Asp Pro Glu Thr Gly Glu Cys 
1               5                   


<210>  34
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  AMIDATION

<400>  34

Leu Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro Xaa Arg Lys Lys 
1               5                   10                  15      


Arg Arg Gln Arg Arg Arg 
            20          


<210>  35
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (11)..(11)
<223>  binding site for cyclization

<400>  35

Xaa Leu Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10              


<210>  36
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (11)..(11)
<223>  binding site for cyclization

<400>  36

Xaa Leu Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10              


<210>  37
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (11)..(11)
<223>  binding site for cyclization

<400>  37

Xaa Leu Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10              


<210>  38
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (11)..(11)
<223>  binding site for cyclization

<400>  38

Xaa Leu Gln Cys Asp Ala Glu Thr Gly Glu Cys Leu Pro 
1               5                   10              


<210>  39
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (11)..(11)
<223>  binding site for cyclization

<400>  39

Xaa Leu Gln Cys Asp Ala Glu Thr Gly Glu Cys Leu Pro 
1               5                   10              


<210>  40
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (11)..(11)
<223>  binding site for cyclization

<400>  40

Xaa Leu Gln Phe Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10              


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (2)..(2)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  AMIDATION

<220>
<221>  BINDING
<222>  (9)..(9)
<223>  binding site for cyclization

<400>  41

Xaa Phe Asp Pro Glu Thr Gly Glu Cys 
1               5                   


<210>  42
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  AMIDATION

<400>  42

Leu Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro Xaa Arg Lys Lys 
1               5                   10                  15      


Arg Arg Gln Arg Arg Arg 
            20          


<210>  43
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  MeAla

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<220>
<221>  BINDING
<222>  (8)..(8)
<223>  binding site for cyclization

<400>  43

Cys Asp Ala Glu Thr Gly Glu Cys 
1               5               


<210>  44
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (11)..(11)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  AMIDATION

<400>  44

Xaa Leu Leu Cys Asp Pro Glu Thr Gly Glu Cys Leu Leu 
1               5                   10              


<210>  45
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  MeLeu

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (11)..(11)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  AMIDATION

<400>  45

Xaa Leu Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10              


<210>  46
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (11)..(11)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  MeLeu

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  AMIDATION

<400>  46

Xaa Leu Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10              


<210>  47
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (11)..(11)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  AMIDATION

<400>  47

Xaa Lys Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10              


<210>  48
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (11)..(11)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  AMIDATION

<400>  48

Xaa Leu Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10              


<210>  49
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (2)..(2)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (11)..(11)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (13)..(13)
<223>  binding site for cyclization

<400>  49

Xaa Lys Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10              


<210>  50
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<400>  50

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  51
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (11)..(11)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  AMIDATION

<400>  51

Xaa Leu Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10              


<210>  52
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (11)..(11)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  AMIDATION

<400>  52

Xaa Val Val Cys Asp Pro Glu Thr Gly Glu Cys Val Val 
1               5                   10              


<210>  53
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (11)..(11)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  AMIDATION

<400>  53

Xaa Lys Lys Cys Asp Pro Glu Thr Gly Glu Cys Lys Lys 
1               5                   10              


<210>  54
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (11)..(11)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  AMIDATION

<400>  54

Xaa Leu Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro Xaa Arg Lys 
1               5                   10                  15      


Lys Arg Arg Gln Arg Arg Arg 
            20              


<210>  55
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (11)..(11)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  AMIDATION

<400>  55

Xaa Leu Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10              


<210>  56
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  AMIDATION

<400>  56

Leu Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro Xaa Arg Lys Lys 
1               5                   10                  15      


Arg Arg Gln Arg Arg Arg 
            20          


<210>  57
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (11)..(11)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (13)..(13)
<223>  AMIDATION

<400>  57

Xaa Lys Lys Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10              


<210>  58
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  AMIDATION

<400>  58

Leu Leu Cys Asp Pro Glu Thr Gly Glu Cys Leu Leu Xaa Arg Lys Lys 
1               5                   10                  15      


Arg Arg Gln Arg Arg Arg 
            20          


<210>  59
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  AMIDATION

<400>  59

Leu Leu Cys Asp Pro Glu Thr Gly Glu Cys Leu Leu Xaa Arg Lys Lys 
1               5                   10                  15      


Arg Arg Gln Arg Arg Arg 
            20          


<210>  60
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  AMIDATION

<400>  60

Leu Leu Cys Asp Pro Glu Thr Gly Glu Cys Leu Leu Xaa Arg Lys Lys 
1               5                   10                  15      


Arg Arg Gln Arg Arg Arg 
            20          


<210>  61
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (11)..(11)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  AMIDATION

<400>  61

Xaa Leu Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10              


<210>  62
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (11)..(11)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  AMIDATION

<400>  62

Xaa Leu Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10              


<210>  63
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  AMIDATION

<400>  63

Leu Leu Cys Asp Pro Glu Thr Gly Glu Cys Leu Leu Xaa Arg Lys Lys 
1               5                   10                  15      


Arg Arg Gln Arg Arg Arg 
            20          


<210>  64
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<400>  64

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  65
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (11)..(11)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  AMIDATION

<400>  65

Xaa Leu Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10              


<210>  66
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  AMIDATION

<400>  66

Leu Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro Xaa Arg Lys Lys 
1               5                   10                  15      


Arg Arg Gln Arg Arg Arg 
            20          


<210>  67
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  AMIDATION

<400>  67

Leu Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro Xaa Arg Lys Lys 
1               5                   10                  15      


Arg Arg Gln Arg Arg Arg 
            20          


<210>  68
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  AMIDATION

<400>  68

Leu Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro Xaa Arg Arg Arg 
1               5                   10                  15      


Arg Arg Arg Arg Arg 
            20      


<210>  69
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  AMIDATION

<400>  69

Leu Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro Xaa Arg Arg Arg 
1               5                   10                  15      


Arg Arg Arg Arg Arg Arg Arg 
            20              


<210>  70
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Stearyl

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<400>  70

Pro Gln Cys Asp Arg Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  71
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Phe(4-F)

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  AMIDATION

<400>  71

Leu Gln Cys Asp Phe Glu Thr Gly Glu Cys Leu Pro Xaa Arg Lys Lys 
1               5                   10                  15      


Arg Arg Gln Arg Arg Arg 
            20          


<210>  72
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Stearyl

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Pro((4S)-F)

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<400>  72

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  73
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Stearyl

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Pro((4S)-NH2)

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<400>  73

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  74
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<400>  74

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  75
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization


<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<400>  75

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  76
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  stearyl

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  76

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  77
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  MeLeu

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<400>  77

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  78
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)'


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Stearyl

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  L-thioproline

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<400>  78

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  79
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)'


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Stearyl

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<400>  79

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  80
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)'


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Miristoyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  D-Pro

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  binding site for cyclization

<400>  80

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  81
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)'


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<400>  81

Pro Lys Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  82
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)'


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<400>  82

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Lys Pro 
1               5                   10          


<210>  83
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)'


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Palmitoyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<400>  83

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  84
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)'


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<400>  84

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  85
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)'


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Lauryl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<400>  85

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  86
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)'


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  alpha-linolenyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<400>  86

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  87
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)'


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Elaidyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<400>  87

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  88
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)'


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Oleyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<400>  88

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  89
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)'


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Behenyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<400>  89

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  90
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)'


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Arachidyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<400>  90

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  91
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)'


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Stearyl (appended to lateral chain)

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<400>  91

Lys Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  92
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   peptidic sequences of the compounds of formula (I)'


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Stearyl (appended to N-alpha atom)

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<400>  92

Lys Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  93
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)'


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Arachidyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  L-thioproline

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<400>  93

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  94
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)'


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Arachidyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  L-thioproline

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<400>  94

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  95
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)'


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Arachidyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<400>  95

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  96
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)'


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  L-thioproline

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<400>  96

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  97
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)'


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  L-thioproline

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<400>  97

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  98
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)'


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Nonadecanoyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<400>  98

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  99
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)'


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (11)..(11)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  Amidation

<400>  99

Xaa Leu Leu Cys Asp Pro Glu Thr Gly Glu Cys Leu Leu 
1               5                   10              


<210>  100
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptidic sequences of the compounds of formula (I)'


<220>
<221>  LIPID
<222>  (1)..(1)
<223>  Stearyl

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (4S)-aminoproline

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (3)..(3)
<223>  binding site for cyclization

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  binding site for cyclization

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Pro

<220>
<221>  BINDING
<222>  (12)..(12)
<223>  binding site for cyclization

<400>  100

Pro Gln Cys Asp Pro Glu Thr Gly Glu Cys Leu Pro 
1               5                   10          


<210>  101
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence motif of Nrf2

<400>  101

Glu Thr Gly Glu 
1               


<210>  102
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  high affinity sequence domain between Nrf2 and the kelch domain 
       of Keap1

<400>  102

Asp Glu Glu Thr Gly Glu 
1               5       


<210>  103
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif containing a beta turn region stablilized by aspartate and 
       threonine residues


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  103

Asp Xaa Glu Thr Gly Glu 
1               5       


<210>  104
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cell penetrating peptide

<400>  104

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  105
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cell penetrating peptide

<400>  105

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
1               5                   10          


<210>  106
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cell penetrating peptide

<400>  106

Arg Arg Arg Arg Arg Arg Arg Arg 
1               5               


<210>  107
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cell penetrating peptide

<400>  107

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  108 
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cell penetrating peptide

<220> 
<221>  MOD_RES
<222>  (15)..(15)
<223>  AMIDATION

<400>  108

Lys Phe His Thr Phe Pro Gln Thr Ala Ile Gly Val Gly Ala Pro 
1               5                   10                  15  


<210>  109
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cell penetrating peptide

<400>  109

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  110
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cell penetrating peptide

<400>  110

Arg Gln Ile Lys Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15  


<210>  111
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cell penetrating peptide

<400>  111

Arg Gly Gly Arg Leu Ser Tyr Ser Arg Arg Arg Phe Ser Thr Ser Thr 
1               5                   10                  15      


Gly Arg 
        


<210>  112
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cell penetrating peptide

<400>  112

Arg Arg Leu Ser Tyr Ser Arg Arg Arg Phe 
1               5                   10  


<210>  113
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cell penetrating peptide

<400>  113

Pro Ile Arg Arg Arg Lys Lys Leu Arg Arg Leu Lys 
1               5                   10          


<210>  114
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cell penetrating peptide

<400>  114

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  115
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cell penetrating peptide

<400>  115

Arg Arg Arg Arg Asn Arg Thr Arg Arg Asn Arg Arg Arg Val Arg 
1               5                   10                  15  


<210>  116
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cell penetrating peptide

<400>  116

Lys Met Thr Arg Ala Gln Arg Arg Ala Ala Ala Arg Arg Asn Arg Trp 
1               5                   10                  15      


Thr Ala Arg 
            


<210>  117
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cell penetrating peptide

<400>  117

Thr Arg Arg Gln Arg Thr Arg Arg Ala Arg Arg Asn Arg 
1               5                   10              


<210>  118
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cell penetrating peptide

<400>  118

Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  119
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cell penetrating peptide

<400>  119

Lys Leu Ala Leu Lys Leu Ala Leu Lys Leu Ala Leu Ala Leu Lys Leu 
1               5                   10                  15      


Ala 
    


<210>  120
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tag2 sequence

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  120

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10  


<210>  121
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tag2 sequence

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  121

Arg Arg Arg Arg Arg Arg Arg Arg 
1               5               


<210>  122
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tag2 sequence

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  AMIDATION

<400>  122

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  123
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tag2 sequence

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  123

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


