                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
 
<120>  METHOD FOR DETERMINING ANTI-DRUG ANTIBODIES IN A MINIPIG SAMPLE

<130>  P34342-WO

<150>  EP 17185220.5
<151>  2017-08-08

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  123
<212>  PRT
<213>  Mus musculus

<400>  1

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ser Ser Gly Tyr Thr Phe Leu Arg Tyr 
            20                  25                  30          


Asn Ile His Trp Leu Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Val Tyr Thr Gly Asn Gly Asn Pro Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ile Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Gly Pro Tyr His Gly Ser Leu Glu Tyr Phe Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Leu Thr Val Ser Ser 
        115                 120             


<210>  2
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  2

Asp Val Val Leu Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Glu Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Glu Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  3
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  3

Gly Tyr Thr Phe Leu Arg Tyr Asn 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  4

Val Tyr Thr Gly Asn Gly Asn Pro 
1               5               


<210>  5
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  5

Ala Arg Trp Gly Pro Tyr His Gly Ser Leu Glu Tyr Phe Phe Asp Tyr 
1               5                   10                  15      


<210>  6
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  6

Gln Ser Leu Leu Asp Ser Asp Gly Glu Thr Tyr 
1               5                   10      


<210>  7
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  7

Leu Val Ser 
1           


<210>  8
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  8

Trp Gln Gly Thr His Phe Pro Gln Thr 
1               5                   


<210>  9
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  9

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Asp Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Phe Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Tyr Asp Gly Asn Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Ser Asn Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  10
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  10

Asp Ile Gln Met Thr Gln Ser Ser Ser Tyr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Ser Cys Glu Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Val Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asn Tyr Thr Leu Ser Ile Ala Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Cys Trp Ser Ile Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  11
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  11

Asp Tyr Ser Ile Thr Ser Gly Tyr Phe 
1               5                   


<210>  12
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  12

Ile Thr Tyr Asp Gly Asn Asn 
1               5           


<210>  13
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  13

Ala Arg Glu Ser Asn Asp Ala Met Asp Tyr 
1               5                   10  


<210>  14
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  14

Asp His Ile Asn Asn Trp 
1               5       


<210>  15
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  15

Gly Val Thr 
1           


<210>  16
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  16

Gln Gln Cys Trp Ser Ile Pro Tyr Thr 
1               5                   


<210>  17
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  17

Glu Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Asn Ser Asn Gly Gly Ala Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ser Tyr Tyr Cys 
                85                  90                  95      


Thr Arg His Gly Leu Leu Asp Trp Tyr Phe Asp Val Trp Gly Ala Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  18
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  18

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Ser Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Val Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Arg Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Glu Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Lys Tyr Val Cys Gln His His Tyr Gly Pro Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg 
            100                 105         


<210>  19
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  19

Gly Phe Pro Phe Ser Asp Tyr Ala 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  20

Ile Asn Ser Asn Gly Gly Ala Thr 
1               5               


<210>  21
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  21

Thr Arg His Gly Leu Leu Asp Trp Tyr Phe Asp Val 
1               5                   10          


<210>  22
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  22

Glu Gly Val Asn Asn Tyr 
1               5       


<210>  23
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  23

Asn Ala Glu 
1           


<210>  24
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  24

Gln His His Tyr Gly Pro Pro Pro Thr 
1               5                   


<210>  25
<211>  115
<212>  PRT
<213>  Mus musculus

<400>  25

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Val Thr Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Phe Pro Glu Ser Gly Gly Thr Thr Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  26
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  26

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Tyr Cys Val Gln Ser His Arg Tyr His Ser 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  27
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  27

Gly Tyr Thr Phe Ser Asn Tyr Trp 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  28

Ile Phe Pro Glu Ser Gly Gly Thr 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  29

Ala Arg Leu Pro Tyr Phe Asp Tyr 
1               5               


<210>  30
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  30

Glu Asn Val Gly Thr Tyr 
1               5       


<210>  31
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  31

Gly Ala Ser 
1           


<210>  32
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  32

Val Gln Ser His Arg Tyr His Ser 
1               5               


