                         SEQUENCE LISTING

<110>  THE CLEVELAND CLINIC FOUNDATION
 
<120>  IMPROVED PEPTIDE EXPRESSION AND APO-H SPECIFIC SUBJECT ANTIBODY 
       DETECTION

<130>  CCF-36652/WO-1/ORD

<150>  US 62/540,663
<151>  2017-08-03

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ile Ser Pro Val Leu Ile Leu Phe Ser Ser Phe Leu Cys His Val 
1               5                   10                  15      


Ala Ile Ala Gly Arg Thr Cys Pro Lys Pro Asp Asp Leu Pro Phe Ser 
            20                  25                  30          


Thr Val Val Pro Leu Lys Thr Phe Tyr Glu Pro Gly Glu Glu Ile Thr 
        35                  40                  45              


Tyr Ser Cys Lys Pro Gly Tyr Val Ser Arg Gly Gly Met Arg Lys Phe 
    50                  55                  60                  


Ile Cys Pro Leu Thr Gly Leu Trp Pro Ile Asn Thr Leu Lys Cys Thr 
65                  70                  75                  80  


Pro Arg Val Cys Pro Phe Ala Gly Ile Leu Glu Asn Gly Ala Val Arg 
                85                  90                  95      


Tyr Thr Thr Phe Glu Tyr Pro Asn Thr Ile Ser Phe Ser Cys Asn Thr 
            100                 105                 110         


Gly Phe Tyr Leu Asn Gly Ala Asp Ser Ala Lys Cys Thr Glu Glu Gly 
        115                 120                 125             


Lys Trp Ser Pro Glu Leu Pro Val Cys Ala Pro Ile Ile Cys Pro Pro 
    130                 135                 140                 


Pro Ser Ile Pro Thr Phe Ala Thr Leu Arg Val Tyr Lys Pro Ser Ala 
145                 150                 155                 160 


Gly Asn Asn Ser Leu Tyr Arg Asp Thr Ala Val Phe Glu Cys Leu Pro 
                165                 170                 175     


Gln His Ala Met Phe Gly Asn Asp Thr Ile Thr Cys Thr Thr His Gly 
            180                 185                 190         


Asn Trp Thr Lys Leu Pro Glu Cys Arg Glu Val Lys Cys Pro Phe Pro 
        195                 200                 205             


Ser Arg Pro Asp Asn Gly Phe Val Asn Tyr Pro Ala Lys Pro Thr Leu 
    210                 215                 220                 


Tyr Tyr Lys Asp Lys Ala Thr Phe Gly Cys His Asp Gly Tyr Ser Leu 
225                 230                 235                 240 


Asp Gly Pro Glu Glu Ile Glu Cys Thr Lys Leu Gly Asn Trp Ser Ala 
                245                 250                 255     


Met Pro Ser Cys Lys Ala Ser Cys Lys Val Pro Val Lys Lys Ala Thr 
            260                 265                 270         


Val Val Tyr Gln Gly Glu Arg Val Lys Ile Gln Glu Lys Phe Lys Asn 
        275                 280                 285             


Gly Met Leu His Gly Asp Lys Val Ser Phe Phe Cys Lys Asn Lys Glu 
    290                 295                 300                 


Lys Lys Cys Ser Tyr Thr Glu Asp Ala Gln Cys Ile Asp Gly Thr Ile 
305                 310                 315                 320 


Glu Val Pro Lys Cys Phe Lys Glu His Ser Ser Leu Ala Phe Trp Lys 
                325                 330                 335     


Thr Asp Ala Ser Asp Val Lys Pro Cys 
            340                 345 


<210>  2
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Arg Thr Cys Pro Lys Pro Asp Asp Leu Pro Phe Ser Thr Val Val 
1               5                   10                  15      


Pro Leu Lys Thr Phe Tyr Glu Pro Gly Glu Glu Ile Thr Tyr Ser Cys 
            20                  25                  30          


Lys Pro Gly Tyr Val Ser Arg Gly Gly Met Arg Lys Phe Ile Cys Pro 
        35                  40                  45              


Leu Thr Gly Leu Trp Pro Ile Asn Thr Leu Lys Cys Thr Pro Arg Val 
    50                  55                  60                  


Cys Pro Phe Ala Gly Ile Leu Glu Asn Gly Ala Val Arg Tyr Thr Thr 
65                  70                  75                  80  


Phe Glu Tyr Pro Asn Thr Ile Ser Phe Ser Cys Asn Thr Gly Phe Tyr 
                85                  90                  95      


Leu Asn Gly Ala Asp Ser Ala Lys Cys Thr Glu Glu Gly Lys Trp Ser 
            100                 105                 110         


Pro Glu Leu Pro Val Cys Ala Pro Ile Ile Cys Pro Pro Pro Ser Ile 
        115                 120                 125             


Pro Thr Phe Ala Thr Leu Arg Val Tyr Lys Pro Ser Ala Gly Asn Asn 
    130                 135                 140                 


Ser Leu Tyr Arg Asp Thr Ala Val Phe Glu Cys Leu Pro Gln His Ala 
145                 150                 155                 160 


Met Phe Gly Asn Asp Thr Ile Thr Cys Thr Thr His Gly Asn Trp Thr 
                165                 170                 175     


Lys Leu Pro Glu Cys Arg Glu Val Lys Cys Pro Phe Pro Ser Arg Pro 
            180                 185                 190         


Asp Asn Gly Phe Val Asn Tyr Pro Ala Lys Pro Thr Leu Tyr Tyr Lys 
        195                 200                 205             


Asp Lys Ala Thr Phe Gly Cys His Asp Gly Tyr Ser Leu Asp Gly Pro 
    210                 215                 220                 


Glu Glu Ile Glu Cys Thr Lys Leu Gly Asn Trp Ser Ala Met Pro Ser 
225                 230                 235                 240 


Cys Lys Ala Ser Cys Lys Leu Pro Val Lys Lys Ala Thr Val Val Tyr 
                245                 250                 255     


Gln Gly Glu Arg Val Lys Ile Gln Glu Lys Phe Lys Asn Gly Met Leu 
            260                 265                 270         


His Gly Asp Lys Val Ser Phe Phe Cys Lys Asn Lys Glu Lys Lys Cys 
        275                 280                 285             


Ser Tyr Thr Glu Asp Ala Gln Cys Ile Asp Gly Thr Ile Glu Val Pro 
    290                 295                 300                 


Lys Cys Phe Lys Glu His Ser Ser Leu Ala Phe Trp Lys Thr Asp Ala 
305                 310                 315                 320 


Ser Asp Val Lys Pro Cys 
                325     


<210>  3
<211>  61
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  3

Arg Thr Cys Pro Lys Pro Asp Asp Leu Pro Phe Ser Thr Val Val Pro 
1               5                   10                  15      


Leu Lys Thr Phe Tyr Glu Pro Gly Glu Glu Ile Thr Tyr Ser Cys Lys 
            20                  25                  30          


Pro Gly Tyr Val Ser Arg Gly Gly Met Arg Lys Phe Ile Cys Pro Leu 
        35                  40                  45              


Thr Gly Leu Trp Pro Ile Asn Thr Leu Lys Cys Thr Pro 
    50                  55                  60      


<210>  4
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  4

Gly Tyr Val Ser Arg Gly Gly Met Arg Lys Phe Ile Cys 
1               5                   10              


<210>  5
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  5

Pro Gly Tyr Val Ser Arg Gly Gly Met Arg Lys Phe Ile Cys Pro 
1               5                   10                  15  


<210>  6
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ile Ser Pro Val Leu Ile Leu Phe Ser Ser Phe Leu Cys His Val 
1               5                   10                  15      


Ala Ile Ala 
            


<210>  7
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr 
            


<210>  8
<211>  19
<212>  PRT
<213>  Pan troglodytes

<400>  8

Met Ile Ser Pro Val Leu Ile Leu Phe Ser Ser Phe Leu Cys His Val 
1               5                   10                  15      


Ala Ile Ala 
            


<210>  9
<211>  19
<212>  PRT
<213>  Macaca mulatta

<400>  9

Met Ile Ser Pro Val Leu Ile Leu Phe Ser Ser Phe Leu Cys His Val 
1               5                   10                  15      


Ala Ile Ala 
            


<210>  10
<211>  19
<212>  PRT
<213>  Gorilla gorilla

<400>  10

Met Ile Ser Pro Val Leu Ile Leu Phe Ser Ser Phe Leu Cys His Val 
1               5                   10                  15      


Ala Ile Ala 
            


<210>  11
<211>  19
<212>  PRT
<213>  Equus ferus caballus

<400>  11

Met Ile Ser Pro Val Leu Ile Leu Phe Ser Ser Phe Leu Cys His Val 
1               5                   10                  15      


Ala Ile Ala 
            


<210>  12
<211>  19
<212>  PRT
<213>  Mus muscullus

<400>  12

Met Val Ser Pro Val Leu Ala Leu Phe Ser Ala Phe Leu Cys His Val 
1               5                   10                  15      


Ala Ile Ala 
            


<210>  13
<211>  19
<212>  PRT
<213>  Rattus norvegicus

<400>  13

Met Ile Ser Pro Ala Leu Ile Phe Phe Ser Ala Phe Leu Cys His Val 
1               5                   10                  15      


Ala Ile Ala 
            


<210>  14
<211>  19
<212>  PRT
<213>  Bos Taurus

<400>  14

Met Leu Pro Pro Ala Leu Val Leu Leu Leu Gly Phe Leu Cys His Val 
1               5                   10                  15      


Ala Ile Ala 
            


<210>  15
<211>  83
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  15
caccatggag acagacacac tcctgctatg ggtactgctg ctctgggttc caggttccac       60

tggtcggacc tgtcccaagc cag                                               83


<210>  16
<211>  70
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  16
ttagcatggc tttacatcgg atgcatcagt tttccaaaaa gccagagaac tgtgttcctt       60

gaagcatttg                                                              70


<210>  17
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  17
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccact          57


<210>  18
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  18
agcgaagggg tgggaaagtt tatctgccct ctc                                    33


<210>  19
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  19
ttcccacccc ttcgctggac acatagcccg g                                      31


<210>  20
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  20
gcagcaggga tggcaaagtt tatctgccct ctc                                    33


<210>  21
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  21
ttgccatccc tgctgcggac acatagcccg g                                      31


<210>  22
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  22

Thr Tyr Ser Cys Lys Pro Gly Tyr Val Ser Arg Gly Gly Met Arg Lys 
1               5                   10                  15      


Phe Ile Cys Pro Leu Thr Gly Leu Trp 
            20                  25  


<210>  23
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  23

Val Ser Phe Phe Cys Lys Asn Lys Glu Lys Lys Cys Ser Tyr Thr Glu 
1               5                   10                  15      


Asp Ala Gln Cys 
            20  


<210>  24
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  24

Leu His Gly Asp Lys Val Ser Phe Phe Cys Lys Asn Lys Glu Lys Lys 
1               5                   10                  15      


Cys Ser Tyr Thr Glu Asp Ala Gln Cys Ile Asp Gly Thr Ile 
            20                  25                  30  


<210>  25
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  25

Phe Lys Asn Gly Met Leu His Gly Asp Lys Val Ser Phe Phe Cys Lys 
1               5                   10                  15      


Asn Lys Glu Lys Lys Cys Ser Tyr Thr Glu Asp Ala Gln Cys Ile Asp 
            20                  25                  30          


Gly Thr Ile Glu Val Pro Lys Cys 
        35                  40  


<210>  26
<211>  58
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  26

Arg Val Cys Pro Phe Ala Gly Ile Leu Glu Asn Gly Ala Val Arg Tyr 
1               5                   10                  15      


Thr Thr Phe Glu Tyr Pro Asn Thr Ile Ser Phe Ser Cys Asn Thr Gly 
            20                  25                  30          


Phe Tyr Leu Asn Gly Ala Asp Ser Ala Lys Cys Thr Glu Glu Gly Lys 
        35                  40                  45              


Trp Ser Pro Glu Leu Pro Val Cys Ala Pro 
    50                  55              


<210>  27
<211>  63
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  27

Ile Ile Cys Pro Pro Pro Ser Ile Pro Thr Phe Ala Thr Leu Arg Val 
1               5                   10                  15      


Tyr Lys Pro Ser Ala Gly Asn Asn Ser Leu Tyr Arg Asp Thr Ala Val 
            20                  25                  30          


Phe Glu Cys Leu Pro Gln His Ala Met Phe Gly Asn Asp Thr Ile Thr 
        35                  40                  45              


Cys Thr Thr His Gly Asn Trp Thr Lys Leu Pro Glu Cys Arg Glu 
    50                  55                  60              


<210>  28
<211>  60
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  28

Val Lys Cys Pro Phe Pro Ser Arg Pro Asp Asn Gly Phe Val Asn Tyr 
1               5                   10                  15      


Pro Ala Lys Pro Thr Leu Tyr Tyr Lys Asp Lys Ala Thr Phe Gly Cys 
            20                  25                  30          


His Asp Gly Tyr Ser Leu Asp Gly Pro Glu Glu Ile Glu Cys Thr Lys 
        35                  40                  45              


Leu Gly Asn Trp Ser Ala Met Pro Ser Cys Lys Ala 
    50                  55                  60  


<210>  29
<211>  83
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  29

Ser Cys Lys Val Pro Val Lys Lys Ala Thr Val Val Tyr Gln Gly Glu 
1               5                   10                  15      


Arg Val Lys Ile Gln Glu Lys Phe Lys Asn Gly Met Leu His Gly Asp 
            20                  25                  30          


Lys Val Ser Phe Phe Cys Lys Asn Lys Glu Lys Lys Cys Ser Tyr Thr 
        35                  40                  45              


Glu Asp Ala Gln Cys Ile Asp Gly Thr Ile Glu Val Pro Lys Cys Phe 
    50                  55                  60                  


Lys Glu His Ser Ser Leu Ala Phe Trp Lys Thr Asp Ala Ser Asp Val 
65                  70                  75                  80  


Lys Pro Cys 
            


<210>  30
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  30

Arg Gly Gly Met Arg 
1               5   


<210>  31
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  31

Leu Leu Leu Trp Val Leu Leu Leu Val Trp Pro 
1               5                   10      


<210>  32
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  32

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr 
            


<210>  33
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  33

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser 
        


<210>  34
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  34

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly 
    


<210>  35
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  35

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


<210>  36
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  36

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp 
1               5                   10                  


<210>  37
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  37

Ser Glu Gly Val Gly 
1               5   


<210>  38
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  38

Ala Ala Gly Met Ala 
1               5   


