                               SEQUENCE LISTING

<110> ANKASA REGENERATIVE THERAPEUTICS, INC.
 
<120> WNT COMPOSITIONS AND METHODS OF PROCESS FROM SERUM-FREE 
      CULTURING CONDITIONS

<130> 47271-708.601

<140>
<141>

<150> 62/630,448
<151> 2018-02-14

<150> 62/539,960
<151> 2017-08-01

<160> 33    

<170> PatentIn version 3.5

<210> 1
<211> 385
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Pro Leu Gly Tyr Phe Leu Leu Leu Cys Ser Leu Lys Gln Ala 
1               5                   10                  15      


Leu Gly Ser Tyr Pro Ile Trp Trp Ser Leu Ala Val Gly Pro Gln Tyr 
            20                  25                  30          


Ser Ser Leu Gly Ser Gln Pro Ile Leu Cys Ala Ser Ile Pro Gly Leu 
        35                  40                  45              


Val Pro Lys Gln Leu Arg Phe Cys Arg Asn Tyr Val Glu Ile Met Pro 
    50                  55                  60                  


Ser Val Ala Glu Gly Ile Lys Ile Gly Ile Gln Glu Cys Gln His Gln 
65                  70                  75                  80  


Phe Arg Gly Arg Arg Trp Asn Cys Thr Thr Val His Asp Ser Leu Ala 
                85                  90                  95      


Ile Phe Gly Pro Val Leu Asp Lys Ala Thr Arg Glu Ser Ala Phe Val 
            100                 105                 110         


His Ala Ile Ala Ser Ala Gly Val Ala Phe Ala Val Thr Arg Ser Cys 
        115                 120                 125             


Ala Glu Gly Thr Ala Ala Ile Cys Gly Cys Ser Ser Arg His Gln Gly 
    130                 135                 140                 


Ser Pro Gly Lys Gly Trp Lys Trp Gly Gly Cys Ser Glu Asp Ile Glu 
145                 150                 155                 160 


Phe Gly Gly Met Val Ser Arg Glu Phe Ala Asp Ala Arg Glu Asn Arg 
                165                 170                 175     


Pro Asp Ala Arg Ser Ala Met Asn Arg His Asn Asn Glu Ala Gly Arg 
            180                 185                 190         


Gln Ala Ile Ala Ser His Met His Leu Lys Cys Lys Cys His Gly Leu 
        195                 200                 205             


Ser Gly Ser Cys Glu Val Lys Thr Cys Trp Trp Ser Gln Pro Asp Phe 
    210                 215                 220                 


Arg Ala Ile Gly Asp Phe Leu Lys Asp Lys Tyr Asp Ser Ala Ser Glu 
225                 230                 235                 240 


Met Val Val Glu Lys His Arg Glu Ser Arg Gly Trp Val Glu Thr Leu 
                245                 250                 255     


Arg Pro Arg Tyr Thr Tyr Phe Lys Val Pro Thr Glu Arg Asp Leu Val 
            260                 265                 270         


Tyr Tyr Glu Ala Ser Pro Asn Phe Cys Glu Pro Asn Pro Glu Thr Gly 
        275                 280                 285             


Ser Phe Gly Thr Arg Asp Arg Thr Cys Asn Val Ser Ser His Gly Ile 
    290                 295                 300                 


Asp Gly Cys Asp Leu Leu Cys Cys Gly Arg Gly His Asn Ala Arg Ala 
305                 310                 315                 320 


Glu Arg Arg Arg Glu Lys Cys Arg Cys Val Phe His Trp Cys Cys Tyr 
                325                 330                 335     


Val Ser Cys Gln Glu Cys Thr Arg Val Tyr Asp Val His Thr Cys Lys 
            340                 345                 350         


Asn Pro Gly Ser Arg Ala Gly Asn Ser Ala His Gln Pro Pro His Pro 
        355                 360                 365             


Gln Pro Pro Val Arg Phe His Pro Pro Leu Arg Arg Ala Gly Lys Val 
    370                 375                 380                 


Pro 
385 


<210> 2
<211> 352
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Pro Leu Gly Tyr Phe Leu Leu Leu Cys Ser Leu Lys Gln Ala 
1               5                   10                  15      


Leu Gly Ser Tyr Pro Ile Trp Trp Ser Leu Ala Val Gly Pro Gln Tyr 
            20                  25                  30          


Ser Ser Leu Gly Ser Gln Pro Ile Leu Cys Ala Ser Ile Pro Gly Leu 
        35                  40                  45              


Val Pro Lys Gln Leu Arg Phe Cys Arg Asn Tyr Val Glu Ile Met Pro 
    50                  55                  60                  


Ser Val Ala Glu Gly Ile Lys Ile Gly Ile Gln Glu Cys Gln His Gln 
65                  70                  75                  80  


Phe Arg Gly Arg Arg Trp Asn Cys Thr Thr Val His Asp Ser Leu Ala 
                85                  90                  95      


Ile Phe Gly Pro Val Leu Asp Lys Ala Thr Arg Glu Ser Ala Phe Val 
            100                 105                 110         


His Ala Ile Ala Ser Ala Gly Val Ala Phe Ala Val Thr Arg Ser Cys 
        115                 120                 125             


Ala Glu Gly Thr Ala Ala Ile Cys Gly Cys Ser Ser Arg His Gln Gly 
    130                 135                 140                 


Ser Pro Gly Lys Gly Trp Lys Trp Gly Gly Cys Ser Glu Asp Ile Glu 
145                 150                 155                 160 


Phe Gly Gly Met Val Ser Arg Glu Phe Ala Asp Ala Arg Glu Asn Arg 
                165                 170                 175     


Pro Asp Ala Arg Ser Ala Met Asn Arg His Asn Asn Glu Ala Gly Arg 
            180                 185                 190         


Gln Ala Ile Ala Ser His Met His Leu Lys Cys Lys Cys His Gly Leu 
        195                 200                 205             


Ser Gly Ser Cys Glu Val Lys Thr Cys Trp Trp Ser Gln Pro Asp Phe 
    210                 215                 220                 


Arg Ala Ile Gly Asp Phe Leu Lys Asp Lys Tyr Asp Ser Ala Ser Glu 
225                 230                 235                 240 


Met Val Val Glu Lys His Arg Glu Ser Arg Gly Trp Val Glu Thr Leu 
                245                 250                 255     


Arg Pro Arg Tyr Thr Tyr Phe Lys Val Pro Thr Glu Arg Asp Leu Val 
            260                 265                 270         


Tyr Tyr Glu Ala Ser Pro Asn Phe Cys Glu Pro Asn Pro Glu Thr Gly 
        275                 280                 285             


Ser Phe Gly Thr Arg Asp Arg Thr Cys Asn Val Ser Ser His Gly Ile 
    290                 295                 300                 


Asp Gly Cys Asp Leu Leu Cys Cys Gly Arg Gly His Asn Ala Arg Ala 
305                 310                 315                 320 


Glu Arg Arg Arg Glu Lys Cys Arg Cys Val Phe His Trp Cys Cys Tyr 
                325                 330                 335     


Val Ser Cys Gln Glu Cys Thr Arg Val Tyr Asp Val His Thr Cys Lys 
            340                 345                 350         


<210> 3
<211> 2826
<212> DNA
<213> Homo sapiens

<400> 3
atggccccac tcggatactt cttactcctc tgcagcctga agcaggctct gggcagctac       60

ccgatctggt ggtcgctggc tgttgggcca cagtattcct ccctgggctc gcagcccatc      120

ctgtgtgcca gcatcccggg cctggtcccc aagcagctcc gcttctgcag gaactacgtg      180

gagatcatgc ccagcgtggc cgagggcatc aagattggca tccaggagtg ccagcaccag      240

ttccgcggcc gccggtggaa ctgcaccacc gtccacgaca gcctggccat cttcgggccc      300

gtgctggaca aagctaccag ggagtcggcc tttgtccacg ccattgcctc agccggtgtg      360

gcctttgcag tgacacgctc atgtgcagaa ggcacggccg ccatctgtgg ctgcagcagc      420

cgccaccagg gctcaccagg caagggctgg aagtggggtg gctgtagcga ggacatcgag      480

tttggtggga tggtgtctcg ggagttcgcc gacgcccggg agaaccggcc agatgcccgc      540

tcagccatga accgccacaa caacgaggct gggcgccagg ccatcgccag ccacatgcac      600

ctcaagtgca agtgccacgg gctgtcgggc agctgcgagg tgaagacatg ctggtggtcg      660

caacccgact tccgcgccat cggtgacttc ctcaaggaca agtacgacag cgcctcggag      720

atggtggtgg agaagcaccg ggagtcccgc ggctgggtgg agaccctgcg gccgcgctac      780

acctacttca aggtgcccac ggagcgcgac ctggtctact acgaggcctc gcccaacttc      840

tgcgagccca accctgagac gggctccttc ggcacgcgcg accgcacctg caacgtcagc      900

tcgcacggca tcgacggctg cgacctgctg tgctgcggcc gcggccacaa cgcgcgagcg      960

gagcggcgcc gggagaagtg ccgctgcgtg ttccactggt gctgctacgt cagctgccag     1020

gagtgcacgc gcgtctacga cgtgcacacc tgcaagtagg caccggccgc ggctccccct     1080

ggacggggcg ggccctgcct gagggtgggc ttttccctgg gtggagcagg actcccacct     1140

aaacggggca gtactcctcc ctgggggcgg gactcctccc tgggggtggg gctcctacct     1200

gggggcagaa ctcctacctg aaggcagggc tcctccctgg agctagtgtc tcctctctgg     1260

tggctgggct gctcctgaat gaggcggagc tccaggatgg ggaggggctc tgcgttggct     1320

tctccctggg gacggggctc ccctggacag aggcggggct acagattggg cggggcttct     1380

cttgggtggg acagggcttc tcctgcgggg gcgaggcccc tcccagtaag ggcgtggctc     1440

tgggtgggcg gggcactagg taggcttcta cctgcaggcg gggctcctcc tgaaggaggc     1500

ggggctctag gatggggcac ggctctgggg taggctgctc cctgagggcg gagcgcctcc     1560

ttaggagtgg ggttttatgg tggatgaggc ttcttcctgg atggggcaga gcttctcctg     1620

accagggcaa ggccccttcc acgggggctg tggctctggg tgggcgtggc ctgcataggc     1680

tccttcctgt gggtggggct tctctgggac caggctccaa tggggcgggg cttctctccg     1740

cgggtgggac tcttccctgg gaaccgccct cctgattaag gcgtggcttc tgcaggaatc     1800

ccggctccag agcaggaaat tcagcccacc agccacctca tccccaaccc cctgtaaggt     1860

tccatccacc cctgcgtcga gctgggaagg ttccatgaag cgagtcgggt ccccaacccg     1920

tgcccctggg atccgagggc ccctctccaa gcgcctggct ttggaatgct ccaggcgcgc     1980

cgacgcctgt gccacccctt cctcagcctg gggtttgacc acccacctga ccaggggccc     2040

tacctgggga aagcctgaag ggcctcccag cccccaaccc caagaccaag cttagtcctg     2100

ggagaggaca gggacttcgc agaggcaagc gaccgaggcc ctcccaaaga ggcccgccct     2160

gcccgggctc ccacaccgtc aggtactcct gccagggaac tggcctgctg cgccccaggc     2220

cccgcccgtc tctgctctgc tcagctgcgc ccccttcttt gcagctgccc agcccctcct     2280

ccctgccctc gggtctcccc acctgcactc catccagcta caggagagat agaagcctct     2340

cgtcccgtcc ctccctttcc tccgcctgtc cacagcccct taagggaaag gtaggaagag     2400

aggtccagcc ccccaggctg cccagagctg ctggtctcat ttgggggcgt tcgggaggtt     2460

tggggggcat caaccccccg actgtgctgc tcgcgaaggt cccacagccc tgagatgggc     2520

cggccccctt cctggcccct catggcggga ctggagaaat ggtccgcttt cctggagcca     2580

atggcccggc ccctcctgac tcatccgcct ggcccgggaa tgaatgggga ggccgctgaa     2640

cccacccggc ccatatccct ggttgcctca tggccagcgc ccctcagcct ctgccactgt     2700

gaaccggctc ccaccctcaa ggtgcgggga gaagaagcgg ccaggcgggg cgccccaaga     2760

gcccaaaaga gggcacaccg ccatcctctg cctcaaattc tgcgtttttg gttttaatgt     2820

tatatc                                                                2826


<210> 4
<211> 694
<212> PRT
<213> Homo sapiens

<400> 4
Met Glu Trp Gly Tyr Leu Leu Glu Val Thr Ser Leu Leu Ala Ala Leu 
1               5                   10                  15      


Ala Leu Leu Gln Arg Ser Ser Gly Ala Ala Ala Ala Ser Ala Lys Glu 
            20                  25                  30          


Leu Ala Cys Gln Glu Ile Thr Val Pro Leu Cys Lys Gly Ile Gly Tyr 
        35                  40                  45              


Asn Tyr Thr Tyr Met Pro Asn Gln Phe Asn His Asp Thr Gln Asp Glu 
    50                  55                  60                  


Ala Gly Leu Glu Val His Gln Phe Trp Pro Leu Val Glu Ile Gln Cys 
65                  70                  75                  80  


Ser Pro Asp Leu Lys Phe Phe Leu Cys Ser Met Tyr Thr Pro Ile Cys 
                85                  90                  95      


Leu Glu Asp Tyr Lys Lys Pro Leu Pro Pro Cys Arg Ser Val Cys Glu 
            100                 105                 110         


Arg Ala Lys Ala Gly Cys Ala Pro Leu Met Arg Gln Tyr Gly Phe Ala 
        115                 120                 125             


Trp Pro Asp Arg Met Arg Cys Asp Arg Leu Pro Glu Gln Gly Asn Pro 
    130                 135                 140                 


Asp Thr Leu Cys Met Asp Tyr Asn Arg Thr Asp Leu Thr Thr Ala Ala 
145                 150                 155                 160 


Pro Ser Pro Pro Arg Arg Leu Pro Pro Pro Pro Pro Gly Glu Gln Pro 
                165                 170                 175     


Pro Ser Gly Ser Gly His Gly Arg Pro Pro Gly Ala Arg Pro Pro His 
            180                 185                 190         


Arg Gly Gly Gly Arg Gly Gly Gly Gly Gly Asp Ala Ala Ala Pro Pro 
        195                 200                 205             


Ala Arg Gly Gly Gly Gly Gly Gly Lys Ala Arg Pro Pro Gly Gly Gly 
    210                 215                 220                 


Ala Ala Pro Cys Glu Pro Gly Cys Gln Cys Arg Ala Pro Met Val Ser 
225                 230                 235                 240 


Val Ser Ser Glu Arg His Pro Leu Tyr Asn Arg Val Lys Thr Gly Gln 
                245                 250                 255     


Ile Ala Asn Cys Ala Leu Pro Cys His Asn Pro Phe Phe Ser Gln Asp 
            260                 265                 270         


Glu Arg Ala Phe Thr Val Phe Trp Ile Gly Leu Trp Ser Val Leu Cys 
        275                 280                 285             


Phe Val Ser Thr Phe Ala Thr Val Ser Thr Phe Leu Ile Asp Met Glu 
    290                 295                 300                 


Arg Phe Lys Tyr Pro Glu Arg Pro Ile Ile Phe Leu Ser Ala Cys Tyr 
305                 310                 315                 320 


Leu Phe Val Ser Val Gly Tyr Leu Val Arg Leu Val Ala Gly His Glu 
                325                 330                 335     


Lys Val Ala Cys Ser Gly Gly Ala Pro Gly Ala Gly Gly Ala Gly Gly 
            340                 345                 350         


Ala Gly Gly Ala Ala Ala Gly Ala Gly Ala Ala Gly Ala Gly Ala Gly 
        355                 360                 365             


Gly Pro Gly Gly Arg Gly Glu Tyr Glu Glu Leu Gly Ala Val Glu Gln 
    370                 375                 380                 


His Val Arg Tyr Glu Thr Thr Gly Pro Ala Leu Cys Thr Val Val Phe 
385                 390                 395                 400 


Leu Leu Val Tyr Phe Phe Gly Met Ala Ser Ser Ile Trp Trp Val Ile 
                405                 410                 415     


Leu Ser Leu Thr Trp Phe Leu Ala Ala Gly Met Lys Trp Gly Asn Glu 
            420                 425                 430         


Ala Ile Ala Gly Tyr Ser Gln Tyr Phe His Leu Ala Ala Trp Leu Val 
        435                 440                 445             


Pro Ser Val Lys Ser Ile Ala Val Leu Ala Leu Ser Ser Val Asp Gly 
    450                 455                 460                 


Asp Pro Val Ala Gly Ile Cys Tyr Val Gly Asn Gln Ser Leu Asp Asn 
465                 470                 475                 480 


Leu Arg Gly Phe Val Leu Ala Pro Leu Val Ile Tyr Leu Phe Ile Gly 
                485                 490                 495     


Thr Met Phe Leu Leu Ala Gly Phe Val Ser Leu Phe Arg Ile Arg Ser 
            500                 505                 510         


Val Ile Lys Gln Gln Asp Gly Pro Thr Lys Thr His Lys Leu Glu Lys 
        515                 520                 525             


Leu Met Ile Arg Leu Gly Leu Phe Thr Val Leu Tyr Thr Val Pro Ala 
    530                 535                 540                 


Ala Val Val Val Ala Cys Leu Phe Tyr Glu Gln His Asn Arg Pro Arg 
545                 550                 555                 560 


Trp Glu Ala Thr His Asn Cys Pro Cys Leu Arg Asp Leu Gln Pro Asp 
                565                 570                 575     


Gln Ala Arg Arg Pro Asp Tyr Ala Val Phe Met Leu Lys Tyr Phe Met 
            580                 585                 590         


Cys Leu Val Val Gly Ile Thr Ser Gly Val Trp Val Trp Ser Gly Lys 
        595                 600                 605             


Thr Leu Glu Ser Trp Arg Ser Leu Cys Thr Arg Cys Cys Trp Ala Ser 
    610                 615                 620                 


Lys Gly Ala Ala Val Gly Gly Gly Ala Gly Ala Thr Ala Ala Gly Gly 
625                 630                 635                 640 


Gly Gly Gly Pro Gly Gly Gly Gly Gly Gly Gly Pro Gly Gly Gly Gly 
                645                 650                 655     


Gly Pro Gly Gly Gly Gly Gly Ser Leu Tyr Ser Asp Val Ser Thr Gly 
            660                 665                 670         


Leu Thr Trp Arg Ser Gly Thr Ala Ser Ser Val Ser Tyr Pro Lys Gln 
        675                 680                 685             


Met Pro Leu Ser Gln Val 
    690                 


<210> 5
<211> 385
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Glu Trp Gly Tyr Leu Leu Glu Val Thr Ser Leu Leu Ala Ala Leu 
1               5                   10                  15      


Ala Leu Leu Gln Arg Ser Ser Gly Ala Ala Ala Ala Ser Ala Lys Glu 
            20                  25                  30          


Leu Ala Cys Gln Glu Ile Thr Val Pro Leu Cys Lys Gly Ile Gly Tyr 
        35                  40                  45              


Asn Tyr Thr Tyr Met Pro Asn Gln Phe Asn His Asp Thr Gln Asp Glu 
    50                  55                  60                  


Ala Gly Leu Glu Val His Gln Phe Trp Pro Leu Val Glu Ile Gln Cys 
65                  70                  75                  80  


Ser Pro Asp Leu Lys Phe Phe Leu Cys Ser Met Tyr Thr Pro Ile Cys 
                85                  90                  95      


Leu Glu Asp Tyr Lys Lys Pro Leu Pro Pro Cys Arg Ser Val Cys Glu 
            100                 105                 110         


Arg Ala Lys Ala Gly Cys Ala Pro Leu Met Arg Gln Tyr Gly Phe Ala 
        115                 120                 125             


Trp Pro Asp Arg Met Arg Cys Asp Arg Leu Pro Glu Gln Gly Asn Pro 
    130                 135                 140                 


Asp Thr Leu Cys Met Asp Tyr Gly Gly Gly Gly Gly Gly Gly Asp Lys 
145                 150                 155                 160 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                165                 170                 175     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            180                 185                 190         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        195                 200                 205             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    210                 215                 220                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
225                 230                 235                 240 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                245                 250                 255     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            260                 265                 270         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        275                 280                 285             


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    290                 295                 300                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
305                 310                 315                 320 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                325                 330                 335     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            340                 345                 350         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        355                 360                 365             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    370                 375                 380                 


Lys 
385 


<210> 6
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Ile Glu Gly Arg Met Asp 
1               5       


<210> 7
<211> 541
<212> PRT
<213> Homo sapiens

<400> 7
Met Ala Gly Ala Ile Ile Glu Asn Met Ser Thr Lys Lys Leu Cys Ile 
1               5                   10                  15      


Val Gly Gly Ile Leu Leu Val Phe Gln Ile Ile Ala Phe Leu Val Gly 
            20                  25                  30          


Gly Leu Ile Ala Pro Gly Pro Thr Thr Ala Val Ser Tyr Met Ser Val 
        35                  40                  45              


Lys Cys Val Asp Ala Arg Lys Asn His His Lys Thr Lys Trp Phe Val 
    50                  55                  60                  


Pro Trp Gly Pro Asn His Cys Asp Lys Ile Arg Asp Ile Glu Glu Ala 
65                  70                  75                  80  


Ile Pro Arg Glu Ile Glu Ala Asn Asp Ile Val Phe Ser Val His Ile 
                85                  90                  95      


Pro Leu Pro His Met Glu Met Ser Pro Trp Phe Gln Phe Met Leu Phe 
            100                 105                 110         


Ile Leu Gln Leu Asp Ile Ala Phe Lys Leu Asn Asn Gln Ile Arg Glu 
        115                 120                 125             


Asn Ala Glu Val Ser Met Asp Val Ser Leu Ala Tyr Arg Asp Asp Ala 
    130                 135                 140                 


Phe Ala Glu Trp Thr Glu Met Ala His Glu Arg Val Pro Arg Lys Leu 
145                 150                 155                 160 


Lys Cys Thr Phe Thr Ser Pro Lys Thr Pro Glu His Glu Gly Arg Tyr 
                165                 170                 175     


Tyr Glu Cys Asp Val Leu Pro Phe Met Glu Ile Gly Ser Val Ala His 
            180                 185                 190         


Lys Phe Tyr Leu Leu Asn Ile Arg Leu Pro Val Asn Glu Lys Lys Lys 
        195                 200                 205             


Ile Asn Val Gly Ile Gly Glu Ile Lys Asp Ile Arg Leu Val Gly Ile 
    210                 215                 220                 


His Gln Asn Gly Gly Phe Thr Lys Val Trp Phe Ala Met Lys Thr Phe 
225                 230                 235                 240 


Leu Thr Pro Ser Ile Phe Ile Ile Met Val Trp Tyr Trp Arg Arg Ile 
                245                 250                 255     


Thr Met Met Ser Arg Pro Pro Val Leu Leu Glu Lys Val Ile Phe Ala 
            260                 265                 270         


Leu Gly Ile Ser Met Thr Phe Ile Asn Ile Pro Val Glu Trp Phe Ser 
        275                 280                 285             


Ile Gly Phe Asp Trp Thr Trp Met Leu Leu Phe Gly Asp Ile Arg Gln 
    290                 295                 300                 


Gly Ile Phe Tyr Ala Met Leu Leu Ser Phe Trp Ile Ile Phe Cys Gly 
305                 310                 315                 320 


Glu His Met Met Asp Gln His Glu Arg Asn His Ile Ala Gly Tyr Trp 
                325                 330                 335     


Lys Gln Val Gly Pro Ile Ala Val Gly Ser Phe Cys Leu Phe Ile Phe 
            340                 345                 350         


Asp Met Cys Glu Arg Gly Val Gln Leu Thr Asn Pro Phe Tyr Ser Ile 
        355                 360                 365             


Trp Thr Thr Asp Ile Gly Thr Glu Leu Ala Met Ala Phe Ile Ile Val 
    370                 375                 380                 


Ala Gly Ile Cys Leu Cys Leu Tyr Phe Leu Phe Leu Cys Phe Met Val 
385                 390                 395                 400 


Phe Gln Val Phe Arg Asn Ile Ser Gly Lys Gln Ser Ser Leu Pro Ala 
                405                 410                 415     


Met Ser Lys Val Arg Arg Leu His Tyr Glu Gly Leu Ile Phe Arg Phe 
            420                 425                 430         


Lys Phe Leu Met Leu Ile Thr Leu Ala Cys Ala Ala Met Thr Val Ile 
        435                 440                 445             


Phe Phe Ile Val Ser Gln Val Thr Glu Gly His Trp Lys Trp Gly Gly 
    450                 455                 460                 


Val Thr Val Gln Val Asn Ser Ala Phe Phe Thr Gly Ile Tyr Gly Met 
465                 470                 475                 480 


Trp Asn Leu Tyr Val Phe Ala Leu Met Phe Leu Tyr Ala Pro Ser His 
                485                 490                 495     


Lys Asn Tyr Gly Glu Asp Gln Ser Asn Gly Asp Leu Gly Val His Ser 
            500                 505                 510         


Gly Glu Glu Leu Gln Leu Thr Thr Thr Ile Thr His Val Asp Gly Pro 
        515                 520                 525             


Thr Glu Ile Tyr Lys Leu Thr Arg Lys Glu Ala Gln Glu 
    530                 535                 540     


<210> 8
<211> 599
<212> PRT
<213> Homo sapiens

<400> 8
Met Lys Leu Leu Lys Leu Thr Gly Phe Ile Phe Phe Leu Phe Phe Leu 
1               5                   10                  15      


Thr Glu Ser Leu Thr Leu Pro Thr Gln Pro Arg Asp Ile Glu Asn Phe 
            20                  25                  30          


Asn Ser Thr Gln Lys Phe Ile Glu Asp Asn Ile Glu Tyr Ile Thr Ile 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Val Gln Glu Ala Thr Phe Glu Glu Met Glu 
    50                  55                  60                  


Lys Leu Val Lys Asp Met Val Glu Tyr Lys Asp Arg Cys Met Ala Asp 
65                  70                  75                  80  


Lys Thr Leu Pro Glu Cys Ser Lys Leu Pro Asn Asn Val Leu Gln Glu 
                85                  90                  95      


Lys Ile Cys Ala Met Glu Gly Leu Pro Gln Lys His Asn Phe Ser His 
            100                 105                 110         


Cys Cys Ser Lys Val Asp Ala Gln Arg Arg Leu Cys Phe Phe Tyr Asn 
        115                 120                 125             


Lys Lys Ser Asp Val Gly Phe Leu Pro Pro Phe Pro Thr Leu Asp Pro 
    130                 135                 140                 


Glu Glu Lys Cys Gln Ala Tyr Glu Ser Asn Arg Glu Ser Leu Leu Asn 
145                 150                 155                 160 


His Phe Leu Tyr Glu Val Ala Arg Arg Asn Pro Phe Val Phe Ala Pro 
                165                 170                 175     


Thr Leu Leu Thr Val Ala Val His Phe Glu Glu Val Ala Lys Ser Cys 
            180                 185                 190         


Cys Glu Glu Gln Asn Lys Val Asn Cys Leu Gln Thr Arg Ala Ile Pro 
        195                 200                 205             


Val Thr Gln Tyr Leu Lys Ala Phe Ser Ser Tyr Gln Lys His Val Cys 
    210                 215                 220                 


Gly Ala Leu Leu Lys Phe Gly Thr Lys Val Val His Phe Ile Tyr Ile 
225                 230                 235                 240 


Ala Ile Leu Ser Gln Lys Phe Pro Lys Ile Glu Phe Lys Glu Leu Ile 
                245                 250                 255     


Ser Leu Val Glu Asp Val Ser Ser Asn Tyr Asp Gly Cys Cys Glu Gly 
            260                 265                 270         


Asp Val Val Gln Cys Ile Arg Asp Thr Ser Lys Val Met Asn His Ile 
        275                 280                 285             


Cys Ser Lys Gln Asp Ser Ile Ser Ser Lys Ile Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Lys Ile Pro Glu Arg Gly Gln Cys Ile Ile Asn Ser Asn Lys Asp 
305                 310                 315                 320 


Asp Arg Pro Lys Asp Leu Ser Leu Arg Glu Gly Lys Phe Thr Asp Ser 
                325                 330                 335     


Glu Asn Val Cys Gln Glu Arg Asp Ala Asp Pro Asp Thr Phe Phe Ala 
            340                 345                 350         


Lys Phe Thr Phe Glu Tyr Ser Arg Arg His Pro Asp Leu Ser Ile Pro 
        355                 360                 365             


Glu Leu Leu Arg Ile Val Gln Ile Tyr Lys Asp Leu Leu Arg Asn Cys 
    370                 375                 380                 


Cys Asn Thr Glu Asn Pro Pro Gly Cys Tyr Arg Tyr Ala Glu Asp Lys 
385                 390                 395                 400 


Phe Asn Glu Thr Thr Glu Lys Ser Leu Lys Met Val Gln Gln Glu Cys 
                405                 410                 415     


Lys His Phe Gln Asn Leu Gly Lys Asp Gly Leu Lys Tyr His Tyr Leu 
            420                 425                 430         


Ile Arg Leu Thr Lys Ile Ala Pro Gln Leu Ser Thr Glu Glu Leu Val 
        435                 440                 445             


Ser Leu Gly Glu Lys Met Val Thr Ala Phe Thr Thr Cys Cys Thr Leu 
    450                 455                 460                 


Ser Glu Glu Phe Ala Cys Val Asp Asn Leu Ala Asp Leu Val Phe Gly 
465                 470                 475                 480 


Glu Leu Cys Gly Val Asn Glu Asn Arg Thr Ile Asn Pro Ala Val Asp 
                485                 490                 495     


His Cys Cys Lys Thr Asn Phe Ala Phe Arg Arg Pro Cys Phe Glu Ser 
            500                 505                 510         


Leu Lys Ala Asp Lys Thr Tyr Val Pro Pro Pro Phe Ser Gln Asp Leu 
        515                 520                 525             


Phe Thr Phe His Ala Asp Met Cys Gln Ser Gln Asn Glu Glu Leu Gln 
    530                 535                 540                 


Arg Lys Thr Asp Arg Phe Leu Val Asn Leu Val Lys Leu Lys His Glu 
545                 550                 555                 560 


Leu Thr Asp Glu Glu Leu Gln Ser Leu Phe Thr Asn Phe Ala Asn Val 
                565                 570                 575     


Val Asp Lys Cys Cys Lys Ala Glu Ser Pro Glu Val Cys Phe Asn Glu 
            580                 585                 590         


Glu Ser Pro Lys Ile Gly Asn 
        595                 


<210> 9
<211> 450
<212> PRT
<213> Homo sapiens

<400> 9
Met Ala Thr Phe Ser Arg Gln Glu Phe Phe Gln Gln Leu Leu Gln Gly 
1               5                   10                  15      


Cys Leu Leu Pro Thr Ala Gln Gln Gly Leu Asp Gln Ile Trp Leu Leu 
            20                  25                  30          


Leu Ala Ile Cys Leu Ala Cys Arg Leu Leu Trp Arg Leu Gly Leu Pro 
        35                  40                  45              


Ser Tyr Leu Lys His Ala Ser Thr Val Ala Gly Gly Phe Phe Ser Leu 
    50                  55                  60                  


Tyr His Phe Phe Gln Leu His Met Val Trp Val Val Leu Leu Ser Leu 
65                  70                  75                  80  


Leu Cys Tyr Leu Val Leu Phe Leu Cys Arg His Ser Ser His Arg Gly 
                85                  90                  95      


Val Phe Leu Ser Val Thr Ile Leu Ile Tyr Leu Leu Met Gly Glu Met 
            100                 105                 110         


His Met Val Asp Thr Val Thr Trp His Lys Met Arg Gly Ala Gln Met 
        115                 120                 125             


Ile Val Ala Met Lys Ala Val Ser Leu Gly Phe Asp Leu Asp Arg Gly 
    130                 135                 140                 


Glu Val Gly Thr Val Pro Ser Pro Val Glu Phe Met Gly Tyr Leu Tyr 
145                 150                 155                 160 


Phe Val Gly Thr Ile Val Phe Gly Pro Trp Ile Ser Phe His Ser Tyr 
                165                 170                 175     


Leu Gln Ala Val Gln Gly Arg Pro Leu Ser Cys Arg Trp Leu Gln Lys 
            180                 185                 190         


Val Ala Arg Ser Leu Ala Leu Ala Leu Leu Cys Leu Val Leu Ser Thr 
        195                 200                 205             


Cys Val Gly Pro Tyr Leu Phe Pro Tyr Phe Ile Pro Leu Asn Gly Asp 
    210                 215                 220                 


Arg Leu Leu Arg Lys Trp Leu Arg Ala Tyr Glu Ser Ala Val Ser Phe 
225                 230                 235                 240 


His Phe Ser Asn Tyr Phe Val Gly Phe Leu Ser Glu Ala Thr Ala Thr 
                245                 250                 255     


Leu Ala Gly Ala Gly Phe Thr Glu Glu Lys Asp His Leu Glu Trp Asp 
            260                 265                 270         


Leu Thr Val Ser Lys Pro Leu Asn Val Glu Leu Pro Arg Ser Met Val 
        275                 280                 285             


Glu Val Val Thr Ser Trp Asn Leu Pro Met Ser Tyr Trp Leu Asn Asn 
    290                 295                 300                 


Tyr Val Phe Lys Asn Ala Leu Arg Leu Gly Thr Phe Ser Ala Val Leu 
305                 310                 315                 320 


Val Thr Tyr Ala Ala Ser Ala Leu Leu His Gly Phe Ser Phe His Leu 
                325                 330                 335     


Ala Ala Val Leu Leu Ser Leu Ala Phe Ile Thr Tyr Val Glu His Val 
            340                 345                 350         


Leu Arg Lys Arg Leu Ala Arg Ile Leu Ser Ala Cys Val Leu Ser Lys 
        355                 360                 365             


Arg Cys Pro Pro Asp Cys Ser His Gln His Arg Leu Gly Leu Gly Val 
    370                 375                 380                 


Arg Ala Leu Asn Leu Leu Phe Gly Ala Leu Ala Ile Phe His Leu Ala 
385                 390                 395                 400 


Tyr Leu Gly Ser Leu Phe Asp Val Asp Val Asp Asp Thr Thr Glu Glu 
                405                 410                 415     


Gln Gly Tyr Gly Met Ala Tyr Thr Val His Lys Trp Ser Glu Leu Ser 
            420                 425                 430         


Trp Ala Ser His Trp Val Thr Phe Gly Cys Trp Ile Phe Tyr Arg Leu 
        435                 440                 445             


Ile Gly 
    450 


<210> 10
<211> 377
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Val Ala Met Pro Gly Ala Glu Asp Asp Val Val Arg 
            20                  25                  30          


Glu Asn Leu Tyr Phe Gln Gly Lys Asp Gly Ser Ser Tyr Pro Ile Trp 
        35                  40                  45              


Trp Ser Leu Ala Val Gly Pro Gln Tyr Ser Ser Leu Gly Ser Gln Pro 
    50                  55                  60                  


Ile Leu Cys Ala Ser Ile Pro Gly Leu Val Pro Lys Gln Leu Arg Phe 
65                  70                  75                  80  


Cys Arg Asn Tyr Val Glu Ile Met Pro Ser Val Ala Glu Gly Ile Lys 
                85                  90                  95      


Ile Gly Ile Gln Glu Cys Gln His Gln Phe Arg Gly Arg Arg Trp Asn 
            100                 105                 110         


Cys Thr Thr Val His Asp Ser Leu Ala Ile Phe Gly Pro Val Leu Asp 
        115                 120                 125             


Lys Ala Thr Arg Glu Ser Ala Phe Val His Ala Ile Ala Ser Ala Gly 
    130                 135                 140                 


Val Ala Phe Ala Val Thr Arg Ser Cys Ala Glu Gly Thr Ala Ala Ile 
145                 150                 155                 160 


Cys Gly Cys Ser Ser Arg His Gln Gly Ser Pro Gly Lys Gly Trp Lys 
                165                 170                 175     


Trp Gly Gly Cys Ser Glu Asp Ile Glu Phe Gly Gly Met Val Ser Arg 
            180                 185                 190         


Glu Phe Ala Asp Ala Arg Glu Asn Arg Pro Asp Ala Arg Ser Ala Met 
        195                 200                 205             


Asn Arg His Asn Asn Glu Ala Gly Arg Gln Ala Ile Ala Ser His Met 
    210                 215                 220                 


His Leu Lys Cys Lys Cys His Gly Leu Ser Gly Ser Cys Glu Val Lys 
225                 230                 235                 240 


Thr Cys Trp Trp Ser Gln Pro Asp Phe Arg Ala Ile Gly Asp Phe Leu 
                245                 250                 255     


Lys Asp Lys Tyr Asp Ser Ala Ser Glu Met Val Val Glu Lys His Arg 
            260                 265                 270         


Glu Ser Arg Gly Trp Val Glu Thr Leu Arg Pro Arg Tyr Thr Tyr Phe 
        275                 280                 285             


Lys Val Pro Thr Glu Arg Asp Leu Val Tyr Tyr Glu Ala Ser Pro Asn 
    290                 295                 300                 


Phe Cys Glu Pro Asn Pro Glu Thr Gly Ser Phe Gly Thr Arg Asp Arg 
305                 310                 315                 320 


Thr Cys Asn Val Ser Ser His Gly Ile Asp Gly Cys Asp Leu Leu Cys 
                325                 330                 335     


Cys Gly Arg Gly His Asn Ala Arg Ala Glu Arg Arg Arg Glu Lys Cys 
            340                 345                 350         


Arg Cys Val Phe His Trp Cys Cys Tyr Val Ser Cys Gln Glu Cys Thr 
        355                 360                 365             


Arg Val Tyr Asp Val His Thr Cys Lys 
    370                 375         


<210> 11
<211> 368
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Asp Tyr Lys Asp Asp Asp Asp Lys Glu Asn Leu Tyr Phe 
            20                  25                  30          


Gln Gly Ser Tyr Pro Ile Trp Trp Ser Leu Ala Val Gly Pro Gln Tyr 
        35                  40                  45              


Ser Ser Leu Gly Ser Gln Pro Ile Leu Cys Ala Ser Ile Pro Gly Leu 
    50                  55                  60                  


Val Pro Lys Gln Leu Arg Phe Cys Arg Asn Tyr Val Glu Ile Met Pro 
65                  70                  75                  80  


Ser Val Ala Glu Gly Ile Lys Ile Gly Ile Gln Glu Cys Gln His Gln 
                85                  90                  95      


Phe Arg Gly Arg Arg Trp Asn Cys Thr Thr Val His Asp Ser Leu Ala 
            100                 105                 110         


Ile Phe Gly Pro Val Leu Asp Lys Ala Thr Arg Glu Ser Ala Phe Val 
        115                 120                 125             


His Ala Ile Ala Ser Ala Gly Val Ala Phe Ala Val Thr Arg Ser Cys 
    130                 135                 140                 


Ala Glu Gly Thr Ala Ala Ile Cys Gly Cys Ser Ser Arg His Gln Gly 
145                 150                 155                 160 


Ser Pro Gly Lys Gly Trp Lys Trp Gly Gly Cys Ser Glu Asp Ile Glu 
                165                 170                 175     


Phe Gly Gly Met Val Ser Arg Glu Phe Ala Asp Ala Arg Glu Asn Arg 
            180                 185                 190         


Pro Asp Ala Arg Ser Ala Met Asn Arg His Asn Asn Glu Ala Gly Arg 
        195                 200                 205             


Gln Ala Ile Ala Ser His Met His Leu Lys Cys Lys Cys His Gly Leu 
    210                 215                 220                 


Ser Gly Ser Cys Glu Val Lys Thr Cys Trp Trp Ser Gln Pro Asp Phe 
225                 230                 235                 240 


Arg Ala Ile Gly Asp Phe Leu Lys Asp Lys Tyr Asp Ser Ala Ser Glu 
                245                 250                 255     


Met Val Val Glu Lys His Arg Glu Ser Arg Gly Trp Val Glu Thr Leu 
            260                 265                 270         


Arg Pro Arg Tyr Thr Tyr Phe Lys Val Pro Thr Glu Arg Asp Leu Val 
        275                 280                 285             


Tyr Tyr Glu Ala Ser Pro Asn Phe Cys Glu Pro Asn Pro Glu Thr Gly 
    290                 295                 300                 


Ser Phe Gly Thr Arg Asp Arg Thr Cys Asn Val Ser Ser His Gly Ile 
305                 310                 315                 320 


Asp Gly Cys Asp Leu Leu Cys Cys Gly Arg Gly His Asn Ala Arg Ala 
                325                 330                 335     


Glu Arg Arg Arg Glu Lys Cys Arg Cys Val Phe His Trp Cys Cys Tyr 
            340                 345                 350         


Val Ser Cys Gln Glu Cys Thr Arg Val Tyr Asp Val His Thr Cys Lys 
        355                 360                 365             


<210> 12
<211> 366
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser His His His His His His Glu Asn Leu Tyr Phe Gln Gly 
            20                  25                  30          


Ser Tyr Pro Ile Trp Trp Ser Leu Ala Val Gly Pro Gln Tyr Ser Ser 
        35                  40                  45              


Leu Gly Ser Gln Pro Ile Leu Cys Ala Ser Ile Pro Gly Leu Val Pro 
    50                  55                  60                  


Lys Gln Leu Arg Phe Cys Arg Asn Tyr Val Glu Ile Met Pro Ser Val 
65                  70                  75                  80  


Ala Glu Gly Ile Lys Ile Gly Ile Gln Glu Cys Gln His Gln Phe Arg 
                85                  90                  95      


Gly Arg Arg Trp Asn Cys Thr Thr Val His Asp Ser Leu Ala Ile Phe 
            100                 105                 110         


Gly Pro Val Leu Asp Lys Ala Thr Arg Glu Ser Ala Phe Val His Ala 
        115                 120                 125             


Ile Ala Ser Ala Gly Val Ala Phe Ala Val Thr Arg Ser Cys Ala Glu 
    130                 135                 140                 


Gly Thr Ala Ala Ile Cys Gly Cys Ser Ser Arg His Gln Gly Ser Pro 
145                 150                 155                 160 


Gly Lys Gly Trp Lys Trp Gly Gly Cys Ser Glu Asp Ile Glu Phe Gly 
                165                 170                 175     


Gly Met Val Ser Arg Glu Phe Ala Asp Ala Arg Glu Asn Arg Pro Asp 
            180                 185                 190         


Ala Arg Ser Ala Met Asn Arg His Asn Asn Glu Ala Gly Arg Gln Ala 
        195                 200                 205             


Ile Ala Ser His Met His Leu Lys Cys Lys Cys His Gly Leu Ser Gly 
    210                 215                 220                 


Ser Cys Glu Val Lys Thr Cys Trp Trp Ser Gln Pro Asp Phe Arg Ala 
225                 230                 235                 240 


Ile Gly Asp Phe Leu Lys Asp Lys Tyr Asp Ser Ala Ser Glu Met Val 
                245                 250                 255     


Val Glu Lys His Arg Glu Ser Arg Gly Trp Val Glu Thr Leu Arg Pro 
            260                 265                 270         


Arg Tyr Thr Tyr Phe Lys Val Pro Thr Glu Arg Asp Leu Val Tyr Tyr 
        275                 280                 285             


Glu Ala Ser Pro Asn Phe Cys Glu Pro Asn Pro Glu Thr Gly Ser Phe 
    290                 295                 300                 


Gly Thr Arg Asp Arg Thr Cys Asn Val Ser Ser His Gly Ile Asp Gly 
305                 310                 315                 320 


Cys Asp Leu Leu Cys Cys Gly Arg Gly His Asn Ala Arg Ala Glu Arg 
                325                 330                 335     


Arg Arg Glu Lys Cys Arg Cys Val Phe His Trp Cys Cys Tyr Val Ser 
            340                 345                 350         


Cys Gln Glu Cys Thr Arg Val Tyr Asp Val His Thr Cys Lys 
        355                 360                 365     


<210> 13
<211> 359
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser His His His His His His Ser Tyr Pro Ile Trp Trp Ser 
            20                  25                  30          


Leu Ala Val Gly Pro Gln Tyr Ser Ser Leu Gly Ser Gln Pro Ile Leu 
        35                  40                  45              


Cys Ala Ser Ile Pro Gly Leu Val Pro Lys Gln Leu Arg Phe Cys Arg 
    50                  55                  60                  


Asn Tyr Val Glu Ile Met Pro Ser Val Ala Glu Gly Ile Lys Ile Gly 
65                  70                  75                  80  


Ile Gln Glu Cys Gln His Gln Phe Arg Gly Arg Arg Trp Asn Cys Thr 
                85                  90                  95      


Thr Val His Asp Ser Leu Ala Ile Phe Gly Pro Val Leu Asp Lys Ala 
            100                 105                 110         


Thr Arg Glu Ser Ala Phe Val His Ala Ile Ala Ser Ala Gly Val Ala 
        115                 120                 125             


Phe Ala Val Thr Arg Ser Cys Ala Glu Gly Thr Ala Ala Ile Cys Gly 
    130                 135                 140                 


Cys Ser Ser Arg His Gln Gly Ser Pro Gly Lys Gly Trp Lys Trp Gly 
145                 150                 155                 160 


Gly Cys Ser Glu Asp Ile Glu Phe Gly Gly Met Val Ser Arg Glu Phe 
                165                 170                 175     


Ala Asp Ala Arg Glu Asn Arg Pro Asp Ala Arg Ser Ala Met Asn Arg 
            180                 185                 190         


His Asn Asn Glu Ala Gly Arg Gln Ala Ile Ala Ser His Met His Leu 
        195                 200                 205             


Lys Cys Lys Cys His Gly Leu Ser Gly Ser Cys Glu Val Lys Thr Cys 
    210                 215                 220                 


Trp Trp Ser Gln Pro Asp Phe Arg Ala Ile Gly Asp Phe Leu Lys Asp 
225                 230                 235                 240 


Lys Tyr Asp Ser Ala Ser Glu Met Val Val Glu Lys His Arg Glu Ser 
                245                 250                 255     


Arg Gly Trp Val Glu Thr Leu Arg Pro Arg Tyr Thr Tyr Phe Lys Val 
            260                 265                 270         


Pro Thr Glu Arg Asp Leu Val Tyr Tyr Glu Ala Ser Pro Asn Phe Cys 
        275                 280                 285             


Glu Pro Asn Pro Glu Thr Gly Ser Phe Gly Thr Arg Asp Arg Thr Cys 
    290                 295                 300                 


Asn Val Ser Ser His Gly Ile Asp Gly Cys Asp Leu Leu Cys Cys Gly 
305                 310                 315                 320 


Arg Gly His Asn Ala Arg Ala Glu Arg Arg Arg Glu Lys Cys Arg Cys 
                325                 330                 335     


Val Phe His Trp Cys Cys Tyr Val Ser Cys Gln Glu Cys Thr Arg Val 
            340                 345                 350         


Tyr Asp Val His Thr Cys Lys 
        355                 


<210> 14
<211> 362
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser His His His His His His Gly Gly Gly Ser Tyr Pro Ile 
            20                  25                  30          


Trp Trp Ser Leu Ala Val Gly Pro Gln Tyr Ser Ser Leu Gly Ser Gln 
        35                  40                  45              


Pro Ile Leu Cys Ala Ser Ile Pro Gly Leu Val Pro Lys Gln Leu Arg 
    50                  55                  60                  


Phe Cys Arg Asn Tyr Val Glu Ile Met Pro Ser Val Ala Glu Gly Ile 
65                  70                  75                  80  


Lys Ile Gly Ile Gln Glu Cys Gln His Gln Phe Arg Gly Arg Arg Trp 
                85                  90                  95      


Asn Cys Thr Thr Val His Asp Ser Leu Ala Ile Phe Gly Pro Val Leu 
            100                 105                 110         


Asp Lys Ala Thr Arg Glu Ser Ala Phe Val His Ala Ile Ala Ser Ala 
        115                 120                 125             


Gly Val Ala Phe Ala Val Thr Arg Ser Cys Ala Glu Gly Thr Ala Ala 
    130                 135                 140                 


Ile Cys Gly Cys Ser Ser Arg His Gln Gly Ser Pro Gly Lys Gly Trp 
145                 150                 155                 160 


Lys Trp Gly Gly Cys Ser Glu Asp Ile Glu Phe Gly Gly Met Val Ser 
                165                 170                 175     


Arg Glu Phe Ala Asp Ala Arg Glu Asn Arg Pro Asp Ala Arg Ser Ala 
            180                 185                 190         


Met Asn Arg His Asn Asn Glu Ala Gly Arg Gln Ala Ile Ala Ser His 
        195                 200                 205             


Met His Leu Lys Cys Lys Cys His Gly Leu Ser Gly Ser Cys Glu Val 
    210                 215                 220                 


Lys Thr Cys Trp Trp Ser Gln Pro Asp Phe Arg Ala Ile Gly Asp Phe 
225                 230                 235                 240 


Leu Lys Asp Lys Tyr Asp Ser Ala Ser Glu Met Val Val Glu Lys His 
                245                 250                 255     


Arg Glu Ser Arg Gly Trp Val Glu Thr Leu Arg Pro Arg Tyr Thr Tyr 
            260                 265                 270         


Phe Lys Val Pro Thr Glu Arg Asp Leu Val Tyr Tyr Glu Ala Ser Pro 
        275                 280                 285             


Asn Phe Cys Glu Pro Asn Pro Glu Thr Gly Ser Phe Gly Thr Arg Asp 
    290                 295                 300                 


Arg Thr Cys Asn Val Ser Ser His Gly Ile Asp Gly Cys Asp Leu Leu 
305                 310                 315                 320 


Cys Cys Gly Arg Gly His Asn Ala Arg Ala Glu Arg Arg Arg Glu Lys 
                325                 330                 335     


Cys Arg Cys Val Phe His Trp Cys Cys Tyr Val Ser Cys Gln Glu Cys 
            340                 345                 350         


Thr Arg Val Tyr Asp Val His Thr Cys Lys 
        355                 360         


<210> 15
<211> 368
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser His His His His His His Gly Gly Gly Gly Ala Gly Gly 
            20                  25                  30          


Gly Gly Ser Tyr Pro Ile Trp Trp Ser Leu Ala Val Gly Pro Gln Tyr 
        35                  40                  45              


Ser Ser Leu Gly Ser Gln Pro Ile Leu Cys Ala Ser Ile Pro Gly Leu 
    50                  55                  60                  


Val Pro Lys Gln Leu Arg Phe Cys Arg Asn Tyr Val Glu Ile Met Pro 
65                  70                  75                  80  


Ser Val Ala Glu Gly Ile Lys Ile Gly Ile Gln Glu Cys Gln His Gln 
                85                  90                  95      


Phe Arg Gly Arg Arg Trp Asn Cys Thr Thr Val His Asp Ser Leu Ala 
            100                 105                 110         


Ile Phe Gly Pro Val Leu Asp Lys Ala Thr Arg Glu Ser Ala Phe Val 
        115                 120                 125             


His Ala Ile Ala Ser Ala Gly Val Ala Phe Ala Val Thr Arg Ser Cys 
    130                 135                 140                 


Ala Glu Gly Thr Ala Ala Ile Cys Gly Cys Ser Ser Arg His Gln Gly 
145                 150                 155                 160 


Ser Pro Gly Lys Gly Trp Lys Trp Gly Gly Cys Ser Glu Asp Ile Glu 
                165                 170                 175     


Phe Gly Gly Met Val Ser Arg Glu Phe Ala Asp Ala Arg Glu Asn Arg 
            180                 185                 190         


Pro Asp Ala Arg Ser Ala Met Asn Arg His Asn Asn Glu Ala Gly Arg 
        195                 200                 205             


Gln Ala Ile Ala Ser His Met His Leu Lys Cys Lys Cys His Gly Leu 
    210                 215                 220                 


Ser Gly Ser Cys Glu Val Lys Thr Cys Trp Trp Ser Gln Pro Asp Phe 
225                 230                 235                 240 


Arg Ala Ile Gly Asp Phe Leu Lys Asp Lys Tyr Asp Ser Ala Ser Glu 
                245                 250                 255     


Met Val Val Glu Lys His Arg Glu Ser Arg Gly Trp Val Glu Thr Leu 
            260                 265                 270         


Arg Pro Arg Tyr Thr Tyr Phe Lys Val Pro Thr Glu Arg Asp Leu Val 
        275                 280                 285             


Tyr Tyr Glu Ala Ser Pro Asn Phe Cys Glu Pro Asn Pro Glu Thr Gly 
    290                 295                 300                 


Ser Phe Gly Thr Arg Asp Arg Thr Cys Asn Val Ser Ser His Gly Ile 
305                 310                 315                 320 


Asp Gly Cys Asp Leu Leu Cys Cys Gly Arg Gly His Asn Ala Arg Ala 
                325                 330                 335     


Glu Arg Arg Arg Glu Lys Cys Arg Cys Val Phe His Trp Cys Cys Tyr 
            340                 345                 350         


Val Ser Cys Gln Glu Cys Thr Arg Val Tyr Asp Val His Thr Cys Lys 
        355                 360                 365             


<210> 16
<211> 151
<212> PRT
<213> Homo sapiens

<400> 16
Met Glu Trp Gly Tyr Leu Leu Glu Val Thr Ser Leu Leu Ala Ala Leu 
1               5                   10                  15      


Ala Leu Leu Gln Arg Ser Ser Gly Ala Ala Ala Ala Ser Ala Lys Glu 
            20                  25                  30          


Leu Ala Cys Gln Glu Ile Thr Val Pro Leu Cys Lys Gly Ile Gly Tyr 
        35                  40                  45              


Asn Tyr Thr Tyr Met Pro Asn Gln Phe Asn His Asp Thr Gln Asp Glu 
    50                  55                  60                  


Ala Gly Leu Glu Val His Gln Phe Trp Pro Leu Val Glu Ile Gln Cys 
65                  70                  75                  80  


Ser Pro Asp Leu Lys Phe Phe Leu Cys Ser Met Tyr Thr Pro Ile Cys 
                85                  90                  95      


Leu Glu Asp Tyr Lys Lys Pro Leu Pro Pro Cys Arg Ser Val Cys Glu 
            100                 105                 110         


Arg Ala Lys Ala Gly Cys Ala Pro Leu Met Arg Gln Tyr Gly Phe Ala 
        115                 120                 125             


Trp Pro Asp Arg Met Arg Cys Asp Arg Leu Pro Glu Gln Gly Asn Pro 
    130                 135                 140                 


Asp Thr Leu Cys Met Asp Tyr 
145                 150     


<210> 17
<211> 172
<212> PRT
<213> Homo sapiens

<400> 17
Met Glu Trp Gly Tyr Leu Leu Glu Val Thr Ser Leu Leu Ala Ala Leu 
1               5                   10                  15      


Ala Leu Leu Gln Arg Ser Ser Gly Ala Ala Ala Ala Ser Ala Lys Glu 
            20                  25                  30          


Leu Ala Cys Gln Glu Ile Thr Val Pro Leu Cys Lys Gly Ile Gly Tyr 
        35                  40                  45              


Asn Tyr Thr Tyr Met Pro Asn Gln Phe Asn His Asp Thr Gln Asp Glu 
    50                  55                  60                  


Ala Gly Leu Glu Val His Gln Phe Trp Pro Leu Val Glu Ile Gln Cys 
65                  70                  75                  80  


Ser Pro Asp Leu Lys Phe Phe Leu Cys Ser Met Tyr Thr Pro Ile Cys 
                85                  90                  95      


Leu Glu Asp Tyr Lys Lys Pro Leu Pro Pro Cys Arg Ser Val Cys Glu 
            100                 105                 110         


Arg Ala Lys Ala Gly Cys Ala Pro Leu Met Arg Gln Tyr Gly Phe Ala 
        115                 120                 125             


Trp Pro Asp Arg Met Arg Cys Asp Arg Leu Pro Glu Gln Gly Asn Pro 
    130                 135                 140                 


Asp Thr Leu Cys Met Asp Tyr Asn Arg Thr Asp Leu Thr Thr Ala Ala 
145                 150                 155                 160 


Pro Ser Pro Pro Arg Arg Leu Pro Pro Pro Pro Pro 
                165                 170         


<210> 18
<211> 406
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Glu Trp Gly Tyr Leu Leu Glu Val Thr Ser Leu Leu Ala Ala Leu 
1               5                   10                  15      


Ala Leu Leu Gln Arg Ser Ser Gly Ala Ala Ala Ala Ser Ala Lys Glu 
            20                  25                  30          


Leu Ala Cys Gln Glu Ile Thr Val Pro Leu Cys Lys Gly Ile Gly Tyr 
        35                  40                  45              


Asn Tyr Thr Tyr Met Pro Asn Gln Phe Asn His Asp Thr Gln Asp Glu 
    50                  55                  60                  


Ala Gly Leu Glu Val His Gln Phe Trp Pro Leu Val Glu Ile Gln Cys 
65                  70                  75                  80  


Ser Pro Asp Leu Lys Phe Phe Leu Cys Ser Met Tyr Thr Pro Ile Cys 
                85                  90                  95      


Leu Glu Asp Tyr Lys Lys Pro Leu Pro Pro Cys Arg Ser Val Cys Glu 
            100                 105                 110         


Arg Ala Lys Ala Gly Cys Ala Pro Leu Met Arg Gln Tyr Gly Phe Ala 
        115                 120                 125             


Trp Pro Asp Arg Met Arg Cys Asp Arg Leu Pro Glu Gln Gly Asn Pro 
    130                 135                 140                 


Asp Thr Leu Cys Met Asp Tyr Asn Arg Thr Asp Leu Thr Thr Ala Ala 
145                 150                 155                 160 


Pro Ser Pro Pro Arg Arg Leu Pro Pro Pro Pro Pro Gly Gly Gly Gly 
                165                 170                 175     


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            180                 185                 190         


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        195                 200                 205             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    210                 215                 220                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
225                 230                 235                 240 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                245                 250                 255     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            260                 265                 270         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        275                 280                 285             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    290                 295                 300                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
305                 310                 315                 320 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                325                 330                 335     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            340                 345                 350         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        355                 360                 365             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    370                 375                 380                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
385                 390                 395                 400 


Ser Leu Ser Pro Gly Lys 
                405     


<210> 19
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 19
His His His His His His 
1               5       


<210> 20
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      10xHis tag

<400> 20
His His His His His His His His His His 
1               5                   10  


<210> 21
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Gly Val Ala Met Pro Gly Ala Glu Asp Asp Val Val 
1               5                   10          


<210> 22
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 23
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210> 24
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210> 25
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Leu Val Pro Arg Gly Ser 
1               5       


<210> 26
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Gly or Ser

<400> 26
Glu Asn Leu Tyr Phe Gln Xaa 
1               5           


<210> 27
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Asp Asp Asp Asp Lys 
1               5   


<210> 28
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Gly Gly Gly Gly Gly Gly 
1               5       


<210> 29
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Gly Gly Gly Gly Ala Gly Gly Gly Gly 
1               5                   


<210> 30
<211> 21
<212> PRT
<213> Thosea asigna virus


<220>
<221> MISC_FEATURE
<222> (1)..(3)
<223> May or may not be present

<400> 30
Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210> 31
<211> 22
<212> PRT
<213> Porcine teschovirus-1


<220>
<221> MISC_FEATURE
<222> (1)..(3)
<223> May or may not be present

<400> 31
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210> 32
<211> 23
<212> PRT
<213> Equine rhinitis A virus


<220>
<221> MISC_FEATURE
<222> (1)..(3)
<223> May or may not be present

<400> 32
Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210> 33
<211> 25
<212> PRT
<213> Foot-and-mouth disease virus


<220>
<221> MISC_FEATURE
<222> (1)..(3)
<223> May or may not be present

<400> 33
Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


