                         SEQUENCE LISTING

<110>  REMD Biotherapeutics, Inc.
 
<120>  CANCER TREATMENT USING ANTIBODIES THAT BIND HUMAN CD134 (OX40) 
       RECEPTOR

<130>  CACRE1.0016WO

<160>  113   

<170>  PatentIn version 3.5

<210>  1
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  1

Leu His Cys Val Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His 
1               5                   10                  15      


Glu Cys Arg Pro Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln 
            20                  25                  30          


Asn Thr Val Cys Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val 
        35                  40                  45              


Ser Ser Lys Pro Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly 
    50                  55                  60                  


Ser Glu Arg Lys Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg 
65                  70                  75                  80  


Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp 
                85                  90                  95      


Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala 
            100                 105                 110         


Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln 
        115                 120                 125             


Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro 
    130                 135                 140                 


Ala Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr 
145                 150                 155                 160 


Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr 
                165                 170                 175     


Arg Pro Val Glu Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly 
            180                 185                 190         


Leu Gly Leu Val Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala 
        195                 200                 205             


Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys 
    210                 215                 220                 


Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
225                 230                 235                 240 


Asp Ala His Ser Thr Leu Ala Lys Ile 
                245                 


<210>  2
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  2

Asp Tyr Ala Ile His 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  3

Asp Tyr Ala Met His 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  4

Ser Tyr Gly Val His 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  5

Ser Tyr Ile Met His 
1               5   


<210>  6
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  6

Glu Asn Tyr Met Asn 
1               5   


<210>  7
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  7

Ser Tyr Val Met His 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  8

Val Ile Asn Thr Tyr Tyr Gly Asp Ala Ala Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  9

Val Ile Ser Thr Tyr Tyr Gly Asp Ala Ala Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  10
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  10

Val Ile Trp Ala Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  11
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  11

Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  12

Asp Ile Asn Arg Asn Asn Gly Gly Thr Arg Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  13
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  13

Leu Asp Asp Phe Val Tyr 
1               5       


<210>  14
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  14

Glu Glu Val Trp Asp 
1               5   


<210>  15
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  15

Tyr Tyr Gly Ser Ser Tyr Thr Met Asp Tyr 
1               5                   10  


<210>  16
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  16

Thr Val Val Gly Tyr Phe Asp Val 
1               5               


<210>  17
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  17

Tyr Tyr Gly Ser Asn Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  18
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  18

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  19
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  19

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  20
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  20

Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn 
1               5                   10      


<210>  21
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  21

Arg Ser Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  22
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  22

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  23
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  23

Tyr Thr Ser Arg Leu Gln Ser 
1               5           


<210>  24
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  24

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  25

Tyr Thr Ser Arg Leu Lys Ser 
1               5           


<210>  26
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  26

Trp Gln Gly Thr His Phe Pro Arg Thr 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  27

Gln Gln Gly Asn Thr Leu Pro Leu Thr 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  28

Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  29
<211>  402
<212>  DNA
<213>  Mus musculus

<400>  29
atgggttgga gctgtatcat cttctttctg gtagcaacag ctacaggtgt gcactcccag       60

gtccagctgc aacagtctgg ggctgagctg gtgaggcctg gggtctcagt gaagatttcc      120

tgcaagggtt ctgactacac attcactgat tatgctatac actgggtgaa gcagagtcct      180

gcaaagagtc tagagtggat tggagttatt aatacttact atggtgatgc tgcctacaac      240

cagaagttcc agggcaaggc cacaatgact gtagacaaat cctccagcgc agcctatatg      300

gaacttgcca gactgacatc tgaggattct gccatctatt actgtgcaag attagacgat      360

tttgtttact ggggccaagg gactctggtc actgtctctg ca                         402


<210>  30
<211>  134
<212>  PRT
<213>  Mus musculus

<400>  30

Met Gly Trp Ser Cys Ile Ile Phe Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Val Ser Val Lys Ile Ser Cys Lys Gly Ser Asp Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Ala Ile His Trp Val Lys Gln Ser Pro Ala Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Asn Thr Tyr Tyr Gly Asp Ala Ala Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Ala Ala Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Asp Asp Phe Val Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ala 
    130                 


<210>  31
<211>  402
<212>  DNA
<213>  Mus musculus

<400>  31
atgggttgga gctgtatcat cttctttctg gtagcaacag ctacaggtgt gcactcccag       60

gtccagctgc agcagtctgg ggctgagctg gtgaggcctg gggtctcagt gaagatttac      120

tgcaagggtt ctggctacac attcactgat tacgctatgc actgggtgaa gcagagtcat      180

gcaaagagtc tagagtggat tggagttatt agtacttact atggtgatgc tgcttacaac      240

cagaaattca aggacaaggc cacaatgact gtagacaaat cctccagcac agcctatatg      300

gaacttgcca gactgacatc tgaggattct gccatctatt actgtgcaag attagacgat      360

tttgtttact ggggccaagg gactctggtc actgtctctg ca                         402


<210>  32
<211>  134
<212>  PRT
<213>  Mus musculus

<400>  32

Met Gly Trp Ser Cys Ile Ile Phe Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Val Ser Val Lys Ile Tyr Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Ala Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Ser Thr Tyr Tyr Gly Asp Ala Ala Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Asp Asp Phe Val Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ala 
    130                 


<210>  33
<211>  396
<212>  DNA
<213>  Mus musculus

<400>  33
atggctgtcc tggtgctgtt cctctgcctg gttgcatttc caagctgtgt cctgtcccag       60

gtgcagctga aggagtcagg acctggcctg gtggcgccct cacagagcct gtccatcacc      120

tgcactgtct ctgggttttc attaagcagc tatggtgtac actgggttcg ccagcctcca      180

ggaaagggtc tggaatggct gggagtaata tgggctggtg gaagcacaga ttataattcg      240

gctctcatgt ccagactgag catcagcaaa gacaactcca agagccaagt tgtcttaaaa      300

atgaacagcc tgcaaactga tgacacagcc atgtactact gtgccagaga agaggtctgg      360

gactggggcc aagggactct ggtcactgtc tctgca                                396


<210>  34
<211>  132
<212>  PRT
<213>  Mus musculus

<400>  34

Met Ala Val Leu Val Leu Phe Leu Cys Leu Val Ala Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Ser Tyr Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ala Gly Gly Ser Thr Asp Tyr Asn Ser 
65                  70                  75                  80  


Ala Leu Met Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Val Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Glu Glu Val Trp Asp Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ala 
    130         


<210>  35
<211>  414
<212>  DNA
<213>  Mus musculus

<400>  35
atggaatgga gttggatatt tctctttctc ctgtcaggaa ctgcaggtgt ccactctgag       60

gtccagctgc agcagtctgg acctgagctg gtaaagcctg gggcttcagt gaagatgtcc      120

tgcaaggctt ctggatacac attcactagc tatattatgc actgggtgaa gcagaagcct      180

gggcagggcc ttgagtggat tggatatatt aatccttaca atgatggtac taagtacaat      240

gaaaagttca aaggcaaggc cacactgact tcagacaaat cctccagcac agcctacatg      300

gagctcagca gcctgacctc tgaggactct gcggtctatt actgtgcaaa ttactacggt      360

agtagctata ctatggacta ctggggtcaa ggaacctcag tcaccgtctc ctca            414


<210>  36
<211>  138
<212>  PRT
<213>  Mus musculus

<400>  36

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Ile Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Asn Tyr Tyr Gly Ser Ser Tyr Thr Met Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135             


<210>  37
<211>  408
<212>  DNA
<213>  Mus musculus

<400>  37
atgggatgga gctggatctt tctctttctc ctgtcaggaa ctgcaggtgt cctctctgag       60

gtccagctgc aacaatctgg acctgagctg gtgaagcctg gggcttcagt gaagatatcc      120

tgtaaggctt ctggatacac gttcactgaa aactacatga actgggtgaa gcagagccat      180

ggaaagagcc ttgagtggat tggagatatt aatcgtaata atggtggtac tagatacaac      240

cagaagttca agggcaaggc cacattgact gtagacaagt cctccagcac agactacatg      300

gagctccgca gcctgacatc tgaggactct gcagtctatt actgtggggg cacggtagta      360

gggtacttcg atgtctgggg cacagggacc acggtcaccg tctcctca                   408


<210>  38
<211>  136
<212>  PRT
<213>  Mus musculus

<400>  38

Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Glu Asn Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asp Ile Asn Arg Asn Asn Gly Gly Thr Arg Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Asp Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Gly Gly Thr Val Val Gly Tyr Phe Asp Val Trp Gly Thr 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser Ser 
    130                 135     


<210>  39
<211>  414
<212>  DNA
<213>  Mus musculus

<400>  39
atggaatgga gttggatatt tctctttctc ctgtcaggaa ctgcaggtgt ccactctgag       60

gtccagctgc agcagtctgg acctgagctg gtaaagcctg gggcttcagt gaagatgtcc      120

tgcaaggctt ctggatacac attcactagc tatgttatgc actgggtgaa gcagaagcct      180

gggcagggcc ttgagtggat tggatatatt aatccttaca atgatggtac taagtacaat      240

gagaagttca aaggcaaggc cacactgact tcagacaaat cctccagcac agcctacatg      300

gagctcagca gcctgacctc tgaggactct gcggtctatt actgtgcaaa ttactacggt      360

agtaactatg ctatggacta ctggggtcaa ggaacctcag tcaccgtctc ctca            414


<210>  40
<211>  138
<212>  PRT
<213>  Mus musculus

<400>  40

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Asn Tyr Tyr Gly Ser Asn Tyr Ala Met Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135             


<210>  41
<211>  396
<212>  DNA
<213>  Mus musculus

<400>  41
atgatgagtc ctgcccagtt cctgtttctg ttagtgctct ggattcggga aaccaacggt       60

gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggtca accggcctcc      120

atctcttgca agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg      180

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac      240

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      300

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttcct      360

cggacgttcg gtggaggcac caagctggaa atcaaa                                396


<210>  42
<211>  132
<212>  PRT
<213>  Mus musculus

<400>  42

Met Met Ser Pro Ala Gln Phe Leu Phe Leu Leu Val Leu Trp Ile Arg 
1               5                   10                  15      


Glu Thr Asn Gly Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser 
            20                  25                  30          


Val Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr 
            100                 105                 110         


Cys Trp Gln Gly Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys 
    130         


<210>  43
<211>  396
<212>  DNA
<213>  Mus musculus

<400>  43
atgatgagtc ctgcccagtt cctgtttctg ttagtgctct ggattcggga aatcaacggt       60

gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc      120

atctcttgca agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg      180

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac      240

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      300

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttcct      360

cggacgttcg gtggaggcac caagctggaa atcaaa                                396


<210>  44
<211>  132
<212>  PRT
<213>  Mus musculus

<400>  44

Met Met Ser Pro Ala Gln Phe Leu Phe Leu Leu Val Leu Trp Ile Arg 
1               5                   10                  15      


Glu Ile Asn Gly Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser 
            20                  25                  30          


Val Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr 
            100                 105                 110         


Cys Trp Gln Gly Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys 
    130         


<210>  45
<211>  387
<212>  DNA
<213>  Mus musculus

<400>  45
atgatgtcct ctgctcagtt ccttggtctc ctgttgctct gttttcaagt cctaggtatc       60

agatgtgata tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga      120

gtcaccatca gttgcagggc aagtcaggac attagcaatt atttaaactg gtatcagcag      180

aaaccagatg gaactgttaa actcctgatc tactacacat caagattaca gtcaggagtc      240

ccatcaaggt tcagtggcag tgggtctgga acagattatt ctctcaccat tagcaacctg      300

gagcaagaag atattgccac ttacttttgc caacagggta atacgcttcc tctcacgttc      360

ggtgctggga ccaagctgga gctgaaa                                          387


<210>  46
<211>  129
<212>  PRT
<213>  Mus musculus

<400>  46

Met Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Val Leu Gly Ile Arg Cys Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys 
    


<210>  47
<211>  381
<212>  DNA
<213>  Mus musculus

<400>  47
atgatgtcct ctgctcagtt ccttggtctc ctgttgctct gttttcaagg taccagatgt       60

gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc      120

atcagttgca gggcaagtca ggacattaga aattatttaa actggtatca gcagaaacca      180

gatggaagtg ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca      240

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      300

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtggac gttcggtgga      360

ggcaccaagc tggaaatcaa a                                                381


<210>  48
<211>  127
<212>  PRT
<213>  Mus musculus

<400>  48

Met Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Ser Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
            100                 105                 110         


Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  49
<211>  381
<212>  DNA
<213>  Mus musculus

<400>  49
atgatgtcct ctgctcagtt ccttggtctc ctgttgctct gttttcaagg taccagatgt       60

gatatccaga tgacacagat tataacctcc ctgtctgcct ctctgggaga cagagtcacc      120

atcagttgca ggtcaagtca ggacattagt aattatttaa attggtatca gcagaaacca      180

gatggaactg ttaaactcct gatctactac acatcaagat taaaatcagg agtcccatca      240

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      300

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtggac gttcggtgga      360

ggcaccaagc tggaaatcaa a                                                381


<210>  50
<211>  127
<212>  PRT
<213>  Mus musculus

<400>  50

Met Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Ile Ile Thr Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ser Ser Gln Asp 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Lys Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
            100                 105                 110         


Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  51
<211>  381
<212>  DNA
<213>  Mus musculus

<400>  51
atgatgtcct ctgctcagtt ccttggtctc ctgttgctct gttttcaagg taccagatgt       60

gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc      120

atcagttgca gggcaagtca ggacattagg aattatttaa actggtatca gcagaaacca      180

gacggaactg ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca      240

aggttcagtg gcagtgggtc tggaacagat tattctctca ccatcagcaa cctggagcaa      300

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtggac gttcggtgga      360

ggcaccaagc tggaaatcaa a                                                381


<210>  52
<211>  127
<212>  PRT
<213>  Mus musculus

<400>  52

Met Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
            100                 105                 110         


Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  53
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  53

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  54
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  54

Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
            20                  25                  30          


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
        35                  40                  45              


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
    50                  55                  60                  


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
65                  70                  75                  80  


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
                85                  90                  95      


Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105 


<210>  55
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  55

Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
1               5                   10                  15      


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
            20                  25                  30          


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
        35                  40                  45              


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
    50                  55                  60                  


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
65                  70                  75                  80  


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
                85                  90                  95      


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            100                 105                 110         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        115                 120                 125             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    130                 135                 140                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
145                 150                 155                 160 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                165                 170                 175     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            180                 185                 190         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        195                 200                 205             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    210                 215                 220                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
225                 230                 235                 240 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                245                 250                 255     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            260                 265                 270         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        275                 280                 285             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    290                 295                 300                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
305                 310                 315                 320 


Ser Leu Ser Leu Ser Pro Gly Lys 
                325             


<210>  56
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable region of a humanized antibody that binds 
       OX40

<400>  56

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Gly Ser Asn Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  57
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable region of a humanized antibody that binds 
       OX40

<400>  57

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ser Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Tyr Tyr Gly Ser Asn Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  58
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable region of a humanized antibody that binds 
       OX40

<400>  58

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ser Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Tyr Tyr Gly Ser Asn Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  59
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable region of a humanized antibody that binds 
       OX40

<400>  59

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ser Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Tyr Tyr Gly Ser Asn Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  60
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable region of a humanized antibody that binds 
       OX40

<400>  60

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Tyr Tyr Gly Ser Asn Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  61
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable region of a humanized antibody that binds 
       OX40

<400>  61

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Gly Ser Asn Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  62
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable region of a humanized antibody that binds 
       OX40

<400>  62

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Ser Ser Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Tyr Tyr Gly Ser Asn Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  63
<211>  105
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable region of a humanized antibody that binds 
       OX40

<400>  63

Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
1               5                   10                  15      


Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr 
        35                  40                  45              


Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    50                  55                  60                  


Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp 
65                  70                  75                  80  


Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  64
<211>  105
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable region of a humanized antibody that binds 
       OX40

<400>  64

Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
1               5                   10                  15      


Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys Leu Leu Ile Tyr Tyr 
        35                  40                  45              


Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    50                  55                  60                  


Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp 
65                  70                  75                  80  


Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  65
<211>  105
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable region of a humanized antibody that binds 
       OX40

<400>  65

Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
1               5                   10                  15      


Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gly Ala Val Lys Leu Leu Ile Tyr Tyr 
        35                  40                  45              


Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    50                  55                  60                  


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
65                  70                  75                  80  


Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  66
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable region of a humanized antibody that binds 
       OX40

<400>  66

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gly Ala Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  67
<211>  105
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable region of a humanized antibody that binds 
       OX40

<400>  67

Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
1               5                   10                  15      


Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Lys Thr Val Lys Leu Leu Ile Tyr Tyr 
        35                  40                  45              


Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    50                  55                  60                  


Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp 
65                  70                  75                  80  


Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  68
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable region of a humanized antibody that binds 
       OX40

<400>  68

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  69
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable region of a humanized antibody that binds 
       OX40

<400>  69

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gly Ala Val Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Tyr Ala Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  70
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable region of a humanized antibody that binds 
       OX40

<400>  70
caggtgcagc tggtccagag cggagcagag gtgaagaaac ccggagcaag cgtgaaggtg       60

tcctgtaagg caagcggcta tactttcaca agctacgtga tgcactgggt caggcaggct      120

ccaggacagc gcctggagtg gatgggatac atcaaccctt acaacgacgg aactaagtac      180

aacgaaaagt tcaaaggccg ggtgaccatt acaagagata cttctgccag taccgcttac      240

atggagctga gctccctgcg atctgaagac accgcagtct actattgcgc cagatattat      300

gggagcaact acgctatgga ttattggggg caggggactc tggtcactgt ctcttca         357


<210>  71
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable region of a humanized antibody that binds 
       OX40

<400>  71
caggtgcagc tggtgcagtc tggggccgaa gtgaagaaac ccggagcatc agtcaaagtc       60

agttgtaagg catcaggcta tacattcaca tcttacgtga tgcactgggt ccggcaggct      120

ccaggacaga gactggagtg gatcgggtac attaaccctt acaacgacgg aactaagtac      180

aacgaaaagt tcaaaggcag ggtgaccatc acatcagata cttctgccag taccgcttac      240

atggagctga gctccctgcg gagcgaagac accgcagtct actattgcgc caattattat      300

ggctcaaact acgctatgga ctattggggg caggggacac tggtgaccgt ctcctca         357


<210>  72
<211>  356
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable region of a humanized antibody that binds 
       OX40

<400>  72
aggtgcagct ggtccagagc ggagcagaag tcaagaaacc cggcgcaagt gtgaagatga       60

gttgtaaggc aagcggctat acattcacat cttacgtgat gcactgggtc aagcaggctc      120

caggacagag gctggagtgg atcgggtaca tcaaccctta caacgacgga actaagtaca      180

acgaaaagtt caaaggccgg gtgaccatca catcagatac ttctgccagt accgcttaca      240

tggagctgag ctccctgaga agcgaagaca ccgcagtcta ctattgcgcc aattattatg      300

gctctaacta tgctatggat tattgggggc agggcactct ggtcaccgtg tcaagc          356


<210>  73
<211>  356
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable region of a humanized antibody that binds 
       OX40

<400>  73
aggtgcagct ggtccagagc ggagcagagg tgaagaaacc cggagcatca gtcaaaatgt       60

cctgtaaggc aagcggctat actttcacat cttacgtgat gcactgggtc aagcaggctc      120

caggacagag gctggagtgg atcgggtaca tcaaccctta caacgacgga actaagtaca      180

acgaaaagtt caaaggccgg gccaccctga catcagatac ttctgccagt accgcttaca      240

tggagctgag ctccctgaga agcgaagaca ccgcagtgta ctattgcgcc aattattatg      300

ggtcaaacta cgctatggac tattgggggc agggcactct ggtcactgtc agcagc          356


<210>  74
<211>  356
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable region of a humanized antibody that binds 
       OX40

<400>  74
aggtgcagct ggtccagagc ggagcagagg tgaagaaacc cggagcatca gtcaaaatgt       60

cctgtaaggc aagcggctat actttcacat cttacgtgat gcactgggtc aagcaggctc      120

caggacagag gctggagtgg atcgggtaca tcaaccctta caacgacgga actaagtaca      180

acgaaaagtt caaaggccgg gccaccctga catcagatac ttctgccagt accgcttaca      240

tggagctgag ctccctgaga agcgaagaca ccgcagtgta ctattgcgcc aattattatg      300

ggtcaaacta cgctatggac tattgggggc agggcactct ggtcactgtc agcagc          356


<210>  75
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable region of a humanized antibody that binds 
       OX40

<400>  75
gaagtgcagc tggtgcagag cggggcagaa gtgaagaagc ctggggaaag cctgaagatt       60

agttgtaaag ggagcggata tacattcact tcttacgtga tgcactgggt ccggcagatg      120

ccaggcaagg gactggagtg gatgggatac atcaaccctt ataatgacgg caccaaatat      180

aacgaaaagt tcaaagggca ggtgaccatc tcagcagaca agtctattag tacagcctac      240

ctgcagtgga gctccctgaa agccagcgac acagctatgt actattgcgc tagatattat      300

ggctcaaact acgctatgga ctactgggga caggggacta tggtcaccgt ctcaagc         357


<210>  76
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable region of a humanized antibody that binds 
       OX40

<400>  76
gaggtccagc tggtgcagag cggagcagag gtcaagaagc ccggcgaatc agtgaagatg       60

tcctgtaagg gaagcggata tactttcact tcctacgtga tgcactgggt caagcagatg      120

cccggcaaag ggctggagtg gatcggatac attaaccctt ataatgacgg caccaagtat      180

aacgaaaagt tcaaagggca ggcaaccctg agctccgata agtcaatcag cacagcctac      240

atgcagctgt ctagtctgaa agccagtgac acagctatgt actattgcgc taattattat      300

gggtcaaact acgcaatgga ttactggggg cagggaacaa tggtcactgt ctcttca         357


<210>  77
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable region of a humanized antibody that binds 
       OX40

<400>  77
gacattcaga tgacccagag cccttccagc ctgagtgcca gcgtcggaga tagagtgaca       60

attacttgcc gcgccagcca ggacattagg aactacctga attggtatca gcagaagccc      120

ggcaaagccc ctaagctgct gatctactat acaagccggc tgcactccgg ggtgccaagt      180

agattctctg gcagtgggtc aggaactgac ttcaccttta caatcagctc cctgcagccc      240

gaggatattg ctacctacta ttgtcagcag ggaaatacac tgccttggac cttcggcggg      300

gggactaaac tggaaatcaa a                                                321


<210>  78
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable region of a humanized antibody that binds 
       OX40

<400>  78
gacattcaga tgacccagag cccttccagc ctgagcgcca gcgtcggaga cagagtgact       60

attacttgta gagccagcca ggacattagg aactacctga attggtatca gcagaagccc      120

ggcaaagccg tgaagctgct gatctactat acaagccggc tgcactccgg ggtccctagt      180

agattctctg gcagtgggtc aggaactgac ttcaccttta caatcagctc cctgcagccc      240

gaggatattg ctacctactt ttgtcagcag ggaaatacac tgccttggac cttcggaggg      300

gggactaaac tggaaatcaa a                                                321


<210>  79
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable region of a humanized antibody that binds 
       OX40

<400>  79
gatattcaga tgacccagtc accttccagt ctgagtgcca gcgtcgggga tagagtcacc       60

attacttgcc gcgccagcca ggacattagg aactacctga attggtatca gcagaagccc      120

ggcggggccg tgaaactgct gatctactat acaagccggc tgcactccgg cgtccctagt      180

agattctctg gaagtggctc agggactgac tttaccctga caatcagctc cctgcagccc      240

gaggatattg ctacctactt ctgtcagcag ggaaatacac tgccttggac cttcggaggg      300

gggactaaac tggaaatcaa a                                                321


<210>  80
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable region of a humanized antibody that binds 
       OX40

<400>  80
gacattcaga tgacccagag ccccagcagc ctgagcgcca gcgtcggaga tagagtgacc       60

attacttgta gagccagcca ggacattagg aactacctga attggtatca gcagaagccc      120

ggcggggccg tgaaactgct gatctactat acaagccggc tgcactccgg cgtccctagt      180

agattctctg gaagtggctc agggactgac tacaccctga caatcagctc cctgcagccc      240

gaggatattg ctacctattt ttgtcagcag ggaaatactc tgccttggac cttcggcgga      300

gggactaaac tggaaatcaa a                                                321


<210>  81
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable region of a humanized antibody that binds 
       OX40

<400>  81
gacattcaga tgacccagag cccttccagc ctgagtgctt ccgtcgggga tagagtgaca       60

attagttgca gagccagcca ggacattagg aactacctga attggtatca gcagaagccc      120

ggcaaaactg tgaagctgct gatctactat accagccggc tgcactccgg ggtccctagt      180

agattctctg gcagtgggtc aggaacagac tacaccttta caatcagctc cctgcagccc      240

gaggatattg ccacctattt ctgtcagcag ggaaatactc tgccttggac cttcggcggc      300

ggaactaaac tggaaatcaa a                                                321


<210>  82
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable region of a humanized antibody that binds 
       OX40

<400>  82
gaaatcgtgc tgacccagtc ccccgccaca ctgagtctgt cccccggaga aagagccacc       60

ctgagctgta gggcaagcca ggatattcgg aactacctga attggtatca gcagaagcca      120

ggacaggcac ctcgactgct gatctactat actagcagac tgcactctgg gattccagct      180

aggttctctg gcagtgggtc aggaaccgac tttaccctga caatcagctc cctggagccc      240

gaagatttcg ccgtgtacta ttgccagcag gggaatactc tgccttggac cttcggccag      300

gggactaaag tggaaatcaa a                                                321


<210>  83
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable region of a humanized antibody that binds 
       OX40

<400>  83
gaaatcgtga tgacccagag cccagccaca ctgtccgcca gcccaggcga gagagtcaca       60

ctgtcttgcc gagccagcca ggatattcgg aactacctga attggtatca gcagaagcca      120

ggaggagccg tgcggctgct gatctactat actagcagac tgcactctgg cgtccctgct      180

aggttctctg gaagtggctc agggaccgac tacaccctga caattagctc cctggagccc      240

gaagattacg ccgtgtattt ttgccagcag ggaaatactc tgccttggac attcggacag      300

gggactaaag tggaaatcaa a                                                321


<210>  84
<211>  468
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain of a chimeric antibody that binds OX40 - 19 aa leader
       sequence

<400>  84

Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Asn Tyr Tyr Gly Ser Asn Tyr Ala Met Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  85
<211>  233
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain of a chimeric antibody that binds OX40 - 19 aa leader
       sequence

<400>  85

Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn 
                85                  90                  95      


Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  86
<211>  468
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  86

Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Tyr Tyr Gly Ser Asn Tyr Ala Met Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  87
<211>  468
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  87

Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Arg Val Thr Ile Thr Ser Asp Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Asn Tyr Tyr Gly Ser Asn Tyr Ala Met Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  88
<211>  468
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  88

Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Arg Val Thr Ile Thr Ser Asp Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Asn Tyr Tyr Gly Ser Asn Tyr Ala Met Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  89
<211>  468
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  89

Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Arg Ala Thr Leu Thr Ser Asp Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Asn Tyr Tyr Gly Ser Asn Tyr Ala Met Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  90
<211>  468
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  90

Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Asn Tyr Tyr Gly Ser Asn Tyr Ala Met Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  91
<211>  468
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  91

Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Tyr Tyr Gly Ser Asn Tyr Ala Met Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  92
<211>  468
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  92

Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Val Lys Met Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Lys Gln Met Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Gln Ala Thr Leu Ser Ser Asp Lys Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Asn Tyr Tyr Gly Ser Asn Tyr Ala Met Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  93
<211>  233
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  93

Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  94
<211>  233
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  94

Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  95
<211>  233
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  95

Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gly Ala Val Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  96
<211>  233
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  96

Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gly Ala Val Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  97
<211>  233
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  97

Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Val Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  98
<211>  233
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  98

Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu 
            20                  25                  30          


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Ile Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  99
<211>  233
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  99

Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Ala 
            20                  25                  30          


Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gly Ala Val Arg 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Pro Glu Asp Tyr Ala Val Tyr Phe Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  100
<211>  1407
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  100
atgggctgga gctggatcct gctgttcctc ctgagcgtga cagcaggagt gcacagccag       60

gtgcagctgg tccagagcgg agcagaggtg aagaaacccg gagcaagcgt gaaggtgtcc      120

tgtaaggcaa gcggctatac tttcacaagc tacgtgatgc actgggtcag gcaggctcca      180

ggacagcgcc tggagtggat gggatacatc aacccttaca acgacggaac taagtacaac      240

gaaaagttca aaggccgggt gaccattaca agagatactt ctgccagtac cgcttacatg      300

gagctgagct ccctgcgatc tgaagacacc gcagtctact attgcgccag atattatggg      360

agcaactacg ctatggatta ttgggggcag gggactctgg tcactgtctc ttcagctagc      420

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      480

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      540

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      600

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      660

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      720

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      780

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      840

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      900

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1020

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1080

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1260

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1320

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1380

agcctctccc tgtctccggg taaatga                                         1407


<210>  101
<211>  1407
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  101
atgggctgga gctggatcct gctgttcctc ctgagcgtga cagcaggagt gcacagccag       60

gtgcagctgg tgcagtctgg ggccgaagtg aagaaacccg gagcatcagt caaagtcagt      120

tgtaaggcat caggctatac attcacatct tacgtgatgc actgggtccg gcaggctcca      180

ggacagagac tggagtggat cgggtacatt aacccttaca acgacggaac taagtacaac      240

gaaaagttca aaggcagggt gaccatcaca tcagatactt ctgccagtac cgcttacatg      300

gagctgagct ccctgcggag cgaagacacc gcagtctact attgcgccaa ttattatggc      360

tcaaactacg ctatggacta ttgggggcag gggacactgg tgaccgtctc ctcagctagc      420

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      480

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      540

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      600

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      660

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      720

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      780

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      840

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      900

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1020

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1080

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1260

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1320

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1380

agcctctccc tgtctccggg taaatga                                         1407


<210>  102
<211>  1407
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  102
atgggctgga gctggatcct gctgttcctc ctgagcgtga cagcaggagt gcacagccag       60

gtgcagctgg tccagagcgg agcagaagtc aagaaacccg gcgcaagtgt gaagatgagt      120

tgtaaggcaa gcggctatac attcacatct tacgtgatgc actgggtcaa gcaggctcca      180

ggacagaggc tggagtggat cgggtacatc aacccttaca acgacggaac taagtacaac      240

gaaaagttca aaggccgggt gaccatcaca tcagatactt ctgccagtac cgcttacatg      300

gagctgagct ccctgagaag cgaagacacc gcagtctact attgcgccaa ttattatggc      360

tctaactatg ctatggatta ttgggggcag ggcactctgg tcaccgtgtc aagcgctagc      420

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      480

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      540

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      600

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      660

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      720

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      780

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      840

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      900

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1020

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1080

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1260

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1320

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1380

agcctctccc tgtctccggg taaatga                                         1407


<210>  103
<211>  1407
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  103
atgggctgga gctggatcct gctgttcctc ctgagcgtga cagcaggagt gcacagccag       60

gtgcagctgg tccagagcgg agcagaggtg aagaaacccg gagcatcagt caaaatgtcc      120

tgtaaggcaa gcggctatac tttcacatct tacgtgatgc actgggtcaa gcaggctcca      180

ggacagaggc tggagtggat cgggtacatc aacccttaca acgacggaac taagtacaac      240

gaaaagttca aaggccgggc caccctgaca tcagatactt ctgccagtac cgcttacatg      300

gagctgagct ccctgagaag cgaagacacc gcagtgtact attgcgccaa ttattatggg      360

tcaaactacg ctatggacta ttgggggcag ggcactctgg tcactgtcag cagcgctagc      420

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      480

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      540

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      600

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      660

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      720

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      780

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      840

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      900

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1020

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1080

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1260

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1320

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1380

agcctctccc tgtctccggg taaatga                                         1407


<210>  104
<211>  1407
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  104
atgggctgga gctggatcct gctgttcctc ctgagcgtga cagcaggagt gcacagccag       60

gtccagctgg tgcagagcgg agcagaggtg aagaaacccg gcgcaagcgt caaggtgtcc      120

tgtaaggcaa gcggctatac ttttacatct tacgtgatgc actgggtcaa acaggctcca      180

ggacagcggc tggagtggat cggatacatt aacccttaca acgacggaac taagtacaac      240

gaaaagttca aaggcaaggc caccctgaca tcagatactt ctgccagtac cgcttacatg      300

gagctgagct ccctgagaag cgaagacacc gcagtgtact attgcgccaa ttattatggc      360

tcaaactatg ctatggatta ttgggggcag ggaacactgg tcaccgtctc atcagctagc      420

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      480

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      540

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      600

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      660

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      720

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      780

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      840

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      900

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1020

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1080

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1260

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1320

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1380

agcctctccc tgtctccggg taaatga                                         1407


<210>  105
<211>  1407
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  105
atgggctgga gctggatcct gctgttcctc ctgagcgtga cagcaggagt gcacagcgaa       60

gtgcagctgg tgcagagcgg ggcagaagtg aagaagcctg gggaaagcct gaagattagt      120

tgtaaaggga gcggatatac attcacttct tacgtgatgc actgggtccg gcagatgcca      180

ggcaagggac tggagtggat gggatacatc aacccttata atgacggcac caaatataac      240

gaaaagttca aagggcaggt gaccatctca gcagacaagt ctattagtac agcctacctg      300

cagtggagct ccctgaaagc cagcgacaca gctatgtact attgcgctag atattatggc      360

tcaaactacg ctatggacta ctggggacag gggactatgg tcaccgtctc aagcgctagc      420

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      480

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      540

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      600

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      660

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      720

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      780

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      840

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      900

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1020

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1080

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1260

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1320

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1380

agcctctccc tgtctccggg taaatga                                         1407


<210>  106
<211>  1407
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  106
atgggctgga gctggatcct gctgttcctc ctgagcgtga cagcaggagt gcacagcgag       60

gtccagctgg tgcagagcgg agcagaggtc aagaagcccg gcgaatcagt gaagatgtcc      120

tgtaagggaa gcggatatac tttcacttcc tacgtgatgc actgggtcaa gcagatgccc      180

ggcaaagggc tggagtggat cggatacatt aacccttata atgacggcac caagtataac      240

gaaaagttca aagggcaggc aaccctgagc tccgataagt caatcagcac agcctacatg      300

cagctgtcta gtctgaaagc cagtgacaca gctatgtact attgcgctaa ttattatggg      360

tcaaactacg caatggatta ctgggggcag ggaacaatgg tcactgtctc ttcagctagc      420

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      480

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      540

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      600

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      660

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      720

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      780

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      840

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      900

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1020

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1080

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1260

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1320

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1380

agcctctccc tgtctccggg taaatga                                         1407


<210>  107
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  107
atgggctgga gctggatcct gctgttcctc ctgagcgtga cagcaggagt gcacagcgac       60

attcagatga cccagagccc ttccagcctg agtgccagcg tcggagatag agtgacaatt      120

acttgccgcg ccagccagga cattaggaac tacctgaatt ggtatcagca gaagcccggc      180

aaagccccta agctgctgat ctactataca agccggctgc actccggggt gccaagtaga      240

ttctctggca gtgggtcagg aactgacttc acctttacaa tcagctccct gcagcccgag      300

gatattgcta cctactattg tcagcaggga aatacactgc cttggacctt cggcgggggg      360

actaaactgg aaatcaaacg aacggtggct gcaccatctg tcttcatctt cccgccatct      420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      660

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt ag                         702


<210>  108
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  108
atgggctgga gctggatcct gctgttcctc ctgagcgtga cagcaggagt gcacagcgac       60

attcagatga cccagagccc ttccagcctg agcgccagcg tcggagacag agtgactatt      120

acttgtagag ccagccagga cattaggaac tacctgaatt ggtatcagca gaagcccggc      180

aaagccgtga agctgctgat ctactataca agccggctgc actccggggt ccctagtaga      240

ttctctggca gtgggtcagg aactgacttc acctttacaa tcagctccct gcagcccgag      300

gatattgcta cctacttttg tcagcaggga aatacactgc cttggacctt cggagggggg      360

actaaactgg aaatcaaacg aacggtggct gcaccatctg tcttcatctt cccgccatct      420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      660

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt ag                         702


<210>  109
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  109
atgggctgga gctggatcct gctgttcctc ctgagcgtga cagcaggagt gcacagcgat       60

attcagatga cccagtcacc ttccagtctg agtgccagcg tcggggatag agtcaccatt      120

acttgccgcg ccagccagga cattaggaac tacctgaatt ggtatcagca gaagcccggc      180

ggggccgtga aactgctgat ctactataca agccggctgc actccggcgt ccctagtaga      240

ttctctggaa gtggctcagg gactgacttt accctgacaa tcagctccct gcagcccgag      300

gatattgcta cctacttctg tcagcaggga aatacactgc cttggacctt cggagggggg      360

actaaactgg aaatcaaacg aacggtggct gcaccatctg tcttcatctt cccgccatct      420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      660

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt ag                         702


<210>  110
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  110
atgggctgga gctggatcct gctgttcctc ctgagcgtga cagcaggagt gcacagcgac       60

attcagatga cccagagccc cagcagcctg agcgccagcg tcggagatag agtgaccatt      120

acttgtagag ccagccagga cattaggaac tacctgaatt ggtatcagca gaagcccggc      180

ggggccgtga aactgctgat ctactataca agccggctgc actccggcgt ccctagtaga      240

ttctctggaa gtggctcagg gactgactac accctgacaa tcagctccct gcagcccgag      300

gatattgcta cctatttttg tcagcaggga aatactctgc cttggacctt cggcggaggg      360

actaaactgg aaatcaaacg aacggtggct gcaccatctg tcttcatctt cccgccatct      420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      660

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt ag                         702


<210>  111
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  111
atgggctgga gctggatcct gctgttcctc ctgagcgtga cagcaggagt gcacagcgac       60

attcagatga cccagagccc ttccagcctg agtgcttccg tcggggatag agtgacaatt      120

agttgcagag ccagccagga cattaggaac tacctgaatt ggtatcagca gaagcccggc      180

aaaactgtga agctgctgat ctactatacc agccggctgc actccggggt ccctagtaga      240

ttctctggca gtgggtcagg aacagactac acctttacaa tcagctccct gcagcccgag      300

gatattgcca cctatttctg tcagcaggga aatactctgc cttggacctt cggcggcgga      360

actaaactgg aaatcaaacg aacggtggct gcaccatctg tcttcatctt cccgccatct      420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      660

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt ag                         702


<210>  112
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  112
atgggctgga gctggatcct gctgttcctc ctgagcgtga cagcaggagt gcacagcgaa       60

atcgtgctga cccagtcccc cgccacactg agtctgtccc ccggagaaag agccaccctg      120

agctgtaggg caagccagga tattcggaac tacctgaatt ggtatcagca gaagccagga      180

caggcacctc gactgctgat ctactatact agcagactgc actctgggat tccagctagg      240

ttctctggca gtgggtcagg aaccgacttt accctgacaa tcagctccct ggagcccgaa      300

gatttcgccg tgtactattg ccagcagggg aatactctgc cttggacctt cggccagggg      360

actaaagtgg aaatcaaacg aacggtggct gcaccatctg tcttcatctt cccgccatct      420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      660

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt ag                         702


<210>  113
<211>  702
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain of a humanized antibody that binds OX40 - 19 aa 
       leader sequence

<400>  113
atgggctgga gctggatcct gctgttcctc ctgagcgtga cagcaggagt gcacagcgaa       60

atcgtgatga cccagagccc agccacactg tccgccagcc caggcgagag agtcacactg      120

tcttgccgag ccagccagga tattcggaac tacctgaatt ggtatcagca gaagccagga      180

ggagccgtgc ggctgctgat ctactatact agcagactgc actctggcgt ccctgctagg      240

ttctctggaa gtggctcagg gaccgactac accctgacaa ttagctccct ggagcccgaa      300

gattacgccg tgtatttttg ccagcaggga aatactctgc cttggacatt cggacagggg      360

actaaagtgg aaatcaaacg aacggtggct gcaccatctg tcttcatctt cccgccatct      420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      660

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt ag                         702


